ATE470713T1 - Polypeptidvarianten mit erhoehter heparin- bindungsfaehigkeit - Google Patents

Polypeptidvarianten mit erhoehter heparin- bindungsfaehigkeit

Info

Publication number
ATE470713T1
ATE470713T1 AT00901137T AT00901137T ATE470713T1 AT E470713 T1 ATE470713 T1 AT E470713T1 AT 00901137 T AT00901137 T AT 00901137T AT 00901137 T AT00901137 T AT 00901137T AT E470713 T1 ATE470713 T1 AT E470713T1
Authority
AT
Austria
Prior art keywords
sub
polypeptide variants
increased heparin
binding capacity
heparin binding
Prior art date
Application number
AT00901137T
Other languages
German (de)
English (en)
Inventor
Walter Sebald
Original Assignee
Osteopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osteopharma Inc filed Critical Osteopharma Inc
Application granted granted Critical
Publication of ATE470713T1 publication Critical patent/ATE470713T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AT00901137T 1999-02-13 2000-01-27 Polypeptidvarianten mit erhoehter heparin- bindungsfaehigkeit ATE470713T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19906096A DE19906096A1 (de) 1999-02-13 1999-02-13 Protein mit einem Heparin-bindenden Epitop
PCT/EP2000/000637 WO2000047736A1 (de) 1999-02-13 2000-01-27 Polypeptidvarianten mit erhöhter heparin-bindungsfähigkeit

Publications (1)

Publication Number Publication Date
ATE470713T1 true ATE470713T1 (de) 2010-06-15

Family

ID=7897433

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901137T ATE470713T1 (de) 1999-02-13 2000-01-27 Polypeptidvarianten mit erhoehter heparin- bindungsfaehigkeit

Country Status (11)

Country Link
US (1) US7253254B1 (enExample)
EP (1) EP1151095B1 (enExample)
JP (3) JP4155711B2 (enExample)
CN (1) CN1169959C (enExample)
AT (1) ATE470713T1 (enExample)
AU (1) AU762387B2 (enExample)
BR (1) BR0008785A (enExample)
CA (1) CA2362496C (enExample)
DE (2) DE19906096A1 (enExample)
RU (1) RU2227743C2 (enExample)
WO (1) WO2000047736A1 (enExample)

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US8734525B2 (en) 2003-12-31 2014-05-27 Warsaw Orthopedic, Inc. Osteoinductive demineralized cancellous bone
WO2005065396A2 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
DE602005023714D1 (de) * 2004-02-20 2010-11-04 Biosurface Eng Tech Inc Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2)
EP1885751B1 (en) * 2005-05-27 2011-11-16 BBS - Bioactive Bone Substitutes Oy Bone morphogenetic protein 6 containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof
US9216212B2 (en) * 2005-08-05 2015-12-22 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
US7951384B2 (en) * 2005-08-05 2011-05-31 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
US8992965B2 (en) 2005-11-01 2015-03-31 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
JP2007332106A (ja) * 2006-06-16 2007-12-27 Okayama Univ 骨形成用徐放性医薬組成物
CA2692240C (en) 2006-06-22 2018-03-13 Biosurface Engineering Technologies, Inc. Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis
US20080206299A1 (en) * 2007-02-27 2008-08-28 Shimp Lawrence A Method for Recovering Minerals From Bone and Use of Same
AU2008265850B2 (en) 2007-06-15 2014-06-26 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2009009688A1 (en) 2007-07-10 2009-01-15 Osteotech, Inc. Delivery system
JP2009045142A (ja) * 2007-08-16 2009-03-05 Okayama Univ 生体内にて基材周囲に骨形成を誘導するための基材処理方法
WO2010039224A2 (en) 2008-09-30 2010-04-08 University Of Massachusetts Medical School Respiratory syncytial virus (rsv) sequences for protein expression and vaccines
JP5799409B2 (ja) * 2008-12-19 2015-10-28 国立大学法人 新潟大学 ヘパリン親和性エリスロポエチン
US9101475B2 (en) 2009-02-12 2015-08-11 Warsaw Orthopedic, Inc. Segmented delivery system
GB201601136D0 (en) 2016-01-21 2016-03-09 Mörgelin Matthias And Abdillahi Suado M Novel polypeptides and medical uses thereof
JP6629488B2 (ja) 2016-12-30 2020-01-15 バイオジェンド セラピューティクス カンパニー リミテッド 組換えポリペプチド、核酸分子、それらを含む組成物及びそれらの製造、使用方法

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Also Published As

Publication number Publication date
CA2362496A1 (en) 2000-08-17
AU2110600A (en) 2000-08-29
DE19906096A1 (de) 2000-08-17
JP4155711B2 (ja) 2008-09-24
JP2002536016A (ja) 2002-10-29
JP2009011323A (ja) 2009-01-22
EP1151095B1 (de) 2010-06-09
BR0008785A (pt) 2001-11-06
EP1151095A1 (de) 2001-11-07
JP2008086319A (ja) 2008-04-17
RU2227743C2 (ru) 2004-04-27
CA2362496C (en) 2011-04-19
CN1340102A (zh) 2002-03-13
AU762387B2 (en) 2003-06-26
US7253254B1 (en) 2007-08-07
WO2000047736A1 (de) 2000-08-17
DE50015938D1 (de) 2010-07-22
CN1169959C (zh) 2004-10-06

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