CN116964195A - 表达外源引入的细胞因子的工程化免疫效应细胞 - Google Patents

表达外源引入的细胞因子的工程化免疫效应细胞 Download PDF

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Publication number
CN116964195A
CN116964195A CN202280015580.4A CN202280015580A CN116964195A CN 116964195 A CN116964195 A CN 116964195A CN 202280015580 A CN202280015580 A CN 202280015580A CN 116964195 A CN116964195 A CN 116964195A
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antigen
cell
ccl
domain
amino acid
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Chinese (zh)
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范晓虎
毛杰
庄秋传
张长江
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Nanjing Legend Biotechnology Co Ltd
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Nanjing Legend Biotechnology Co Ltd
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4261—Proteoglycans, e.g. glypican, brevican or CSPG4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K2239/51—Stomach
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    • A61K2239/53—Liver
    • A—HUMAN NECESSITIES
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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CN202280015580.4A 2021-02-26 2022-02-25 表达外源引入的细胞因子的工程化免疫效应细胞 Pending CN116964195A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2021078227 2021-02-26
CNPCT/CN2021/078227 2021-02-26
PCT/CN2022/077964 WO2022179613A1 (en) 2021-02-26 2022-02-25 Engineered immune effector cells expressing exogenously introduced cytokines

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CN116964195A true CN116964195A (zh) 2023-10-27

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US (1) US20240316201A1 (https=)
EP (1) EP4298210A4 (https=)
JP (1) JP2024507958A (https=)
KR (1) KR20230147619A (https=)
CN (1) CN116964195A (https=)
WO (1) WO2022179613A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20260016890A (ko) * 2024-07-24 2026-02-04 서울대학교산학협력단 안전하며 효과적인 유전자세포치료 시스템

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3017442A1 (en) * 2016-03-17 2017-09-21 Yamaguchi University Immunocompetent cell and expression vector expressing regulatory factors of immune function
JP2020530280A (ja) * 2017-07-03 2020-10-22 トルク セラピューティクス， インコーポレイテッド 免疫刺激性融合分子およびその使用
EP3781176A4 (en) * 2018-04-09 2022-05-25 The Trustees of the University of Pennsylvania METHODS AND COMPOSITIONS USING A VIRAL VECTOR FOR THE EXPRESSION OF A TRANSGENE AND AN EFFECTOR
US11319380B2 (en) * 2018-06-04 2022-05-03 Precigen, Inc. MUC16 specific chimeric antigen receptors and uses thereof
JP7241161B2 (ja) * 2018-08-01 2023-03-16 イミュニティーバイオ、インコーポレイテッド 細胞免疫療法の安定した遺伝子改変のための、ホーミング受容体又はサイトカインとキメラ抗原受容体とを含むクアドリシストロニックシステム
US10918667B2 (en) * 2018-11-20 2021-02-16 Innovative Cellular Therapeutics CO., LTD. Modified cell expressing therapeutic agent and uses thereof
EP3907280A4 (en) * 2018-12-13 2022-06-22 CRAGE medical Co., Limited ANTI-GPC3 IMMUNE EFFECTOR CELL AND USE THEREOF
CN113557242A (zh) * 2019-02-01 2021-10-26 得克萨斯大学体系董事会 用于治疗癌症的修饰的il-12 t细胞疗法
CN110818803B (zh) * 2019-07-24 2023-01-03 浙江启新生物技术有限公司 分泌表达il15ra-il15融合蛋白、ccl21趋化因子的嵌合抗原受体-t细胞及应用
CN110590960B (zh) * 2019-09-26 2020-08-28 武汉波睿达生物科技有限公司 以cd99为靶点的嵌合抗原受体及其应用
CN110684739B (zh) * 2019-11-11 2022-05-27 深圳市体内生物医药科技有限公司 一种嵌合抗原受体t细胞及其应用
CA3170023A1 (en) * 2020-02-27 2021-09-02 Nanjing Legend Biotech Co., Ltd. Antibodies and chimeric antigen receptors targeting glypican-3 (gpc3) and methods of use thereof
CN112175998A (zh) * 2020-10-12 2021-01-05 广东昭泰体内生物医药科技有限公司 一种嵌合抗原受体t细胞及其应用

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US20240316201A1 (en) 2024-09-26
EP4298210A4 (en) 2025-02-26
WO2022179613A1 (en) 2022-09-01
KR20230147619A (ko) 2023-10-23
EP4298210A1 (en) 2024-01-03
JP2024507958A (ja) 2024-02-21

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