CN116802190A - 特异于转铁蛋白受体1（TfR1）的双环肽配体 - Google Patents
特异于转铁蛋白受体1（TfR1）的双环肽配体 Download PDFInfo
- Publication number
- CN116802190A CN116802190A CN202180089518.5A CN202180089518A CN116802190A CN 116802190 A CN116802190 A CN 116802190A CN 202180089518 A CN202180089518 A CN 202180089518A CN 116802190 A CN116802190 A CN 116802190A
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- China
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- bcy
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2017927.1A GB202017927D0 (en) | 2020-11-13 | 2020-11-13 | Bicyclic peptide ligands specific for transferrin |
| GB2017927.1 | 2020-11-13 | ||
| GB2106903.4 | 2021-05-14 | ||
| GBGB2106903.4A GB202106903D0 (en) | 2021-05-14 | 2021-05-14 | Bicycle peptide ligands specific for transferrin |
| US202163261820P | 2021-09-29 | 2021-09-29 | |
| US63/261,820 | 2021-09-29 | ||
| PCT/GB2021/052927 WO2022101633A1 (en) | 2020-11-13 | 2021-11-12 | BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TfR1) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116802190A true CN116802190A (zh) | 2023-09-22 |
Family
ID=81600834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180089518.5A Pending CN116802190A (zh) | 2020-11-13 | 2021-11-12 | 特异于转铁蛋白受体1（TfR1）的双环肽配体 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11970555B2 (https=) |
| EP (1) | EP4244235A1 (https=) |
| JP (1) | JP7848202B2 (https=) |
| KR (1) | KR20230107589A (https=) |
| CN (1) | CN116802190A (https=) |
| AR (1) | AR126029A1 (https=) |
| AU (1) | AU2021376917A1 (https=) |
| CA (1) | CA3201414A1 (https=) |
| IL (1) | IL302713A (https=) |
| MX (1) | MX2023005624A (https=) |
| SA (1) | SA523440745B1 (https=) |
| WO (1) | WO2022101633A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230107589A (ko) | 2020-11-13 | 2023-07-17 | 바이사이클티엑스 리미티드 | 트랜스페린 수용체 1 (TfR1)에 특이적인 비시클릭 펩티드 리간드 |
| GB202206431D0 (en) * | 2022-05-03 | 2022-06-15 | Bicycletx Ltd | Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1) |
| EP4689119A1 (en) * | 2023-04-05 | 2026-02-11 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing pln expression |
| WO2025073871A1 (en) | 2023-10-03 | 2025-04-10 | Bicycletx Limited | Bicyclic peptide ligand complexes specific for tfr1 |
| GB202316970D0 (en) * | 2023-11-06 | 2023-12-20 | Bicycletx Ltd | Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1) |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2653545A1 (en) | 2008-02-05 | 2013-10-23 | Bicycle Therapeutics Limited | Methods and compositions |
| GB0914110D0 (en) | 2009-08-12 | 2009-09-16 | Medical Res Council | Peptide libraries |
| EP3218411B1 (en) * | 2014-11-14 | 2022-01-12 | Ossianix, Inc. | Variable new antigen receptors (vnars) directed against transferrin receptor (tfr) and their use |
| CN104650186A (zh) | 2015-03-09 | 2015-05-27 | 中国药科大学 | 一种能够与TfR1特异性结合的活性肽及其应用 |
| GB201706477D0 (en) * | 2017-04-24 | 2017-06-07 | Bicycle Therapeutics Ltd | Modification of polypeptides |
| US10857196B2 (en) * | 2017-04-27 | 2020-12-08 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| WO2019089395A1 (en) | 2017-11-02 | 2019-05-09 | Ossianix, Inc. | Improved tfr-selective binding peptides capable of crossing the blood brain barrier |
| CN111902429A (zh) | 2018-02-23 | 2020-11-06 | 拜斯科技术开发有限公司 | 多聚体双环肽配体 |
| WO2020084305A1 (en) | 2018-10-23 | 2020-04-30 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| US12492224B2 (en) * | 2018-12-21 | 2025-12-09 | Bicycletx Limited | Bicyclic peptide ligands specific for PD-L1 |
| GB201912320D0 (en) * | 2019-08-28 | 2019-10-09 | Bicycletx Ltd | PBP Binding Bicyclic Peptide Ligands |
| KR20230107589A (ko) | 2020-11-13 | 2023-07-17 | 바이사이클티엑스 리미티드 | 트랜스페린 수용체 1 (TfR1)에 특이적인 비시클릭 펩티드 리간드 |
-
2021
- 2021-11-12 KR KR1020237017137A patent/KR20230107589A/ko active Pending
- 2021-11-12 AU AU2021376917A patent/AU2021376917A1/en active Pending
- 2021-11-12 IL IL302713A patent/IL302713A/en unknown
- 2021-11-12 EP EP21819173.2A patent/EP4244235A1/en active Pending
- 2021-11-12 CA CA3201414A patent/CA3201414A1/en active Pending
- 2021-11-12 AR ARP210103150A patent/AR126029A1/es unknown
- 2021-11-12 JP JP2023528449A patent/JP7848202B2/ja active Active
- 2021-11-12 WO PCT/GB2021/052927 patent/WO2022101633A1/en not_active Ceased
- 2021-11-12 MX MX2023005624A patent/MX2023005624A/es unknown
- 2021-11-12 US US17/454,665 patent/US11970555B2/en active Active
- 2021-11-12 CN CN202180089518.5A patent/CN116802190A/zh active Pending
-
2023
- 2023-05-11 SA SA523440745A patent/SA523440745B1/ar unknown
-
2024
- 2024-03-19 US US18/610,009 patent/US20240391959A1/en not_active Abandoned
-
2025
- 2025-04-23 US US19/187,619 patent/US20250340595A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022101633A1 (en) | 2022-05-19 |
| AU2021376917A1 (en) | 2023-06-29 |
| IL302713A (en) | 2023-07-01 |
| JP2023549229A (ja) | 2023-11-22 |
| EP4244235A1 (en) | 2023-09-20 |
| US20250340595A1 (en) | 2025-11-06 |
| JP7848202B2 (ja) | 2026-04-20 |
| MX2023005624A (es) | 2023-05-24 |
| US20220194988A1 (en) | 2022-06-23 |
| AU2021376917A9 (en) | 2024-09-12 |
| AR126029A1 (es) | 2023-09-06 |
| SA523440745B1 (ar) | 2024-07-24 |
| US20240391959A1 (en) | 2024-11-28 |
| US11970555B2 (en) | 2024-04-30 |
| KR20230107589A (ko) | 2023-07-17 |
| CA3201414A1 (en) | 2022-05-19 |
| TW202233664A (zh) | 2022-09-01 |
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Legal Events
| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |