JP7848202B2 - トランスフェリン受容体１（ＴｆＲ１）に特異的な二環式ペプチドリガンド - Google Patents
トランスフェリン受容体１（ＴｆＲ１）に特異的な二環式ペプチドリガンドInfo
- Publication number
- JP7848202B2 JP7848202B2 JP2023528449A JP2023528449A JP7848202B2 JP 7848202 B2 JP7848202 B2 JP 7848202B2 JP 2023528449 A JP2023528449 A JP 2023528449A JP 2023528449 A JP2023528449 A JP 2023528449A JP 7848202 B2 JP7848202 B2 JP 7848202B2
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- JP
- Japan
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- iii
- isyc
- sar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2017927.1 | 2020-11-13 | ||
| GBGB2017927.1A GB202017927D0 (en) | 2020-11-13 | 2020-11-13 | Bicyclic peptide ligands specific for transferrin |
| GB2106903.4 | 2021-05-14 | ||
| GBGB2106903.4A GB202106903D0 (en) | 2021-05-14 | 2021-05-14 | Bicycle peptide ligands specific for transferrin |
| US202163261820P | 2021-09-29 | 2021-09-29 | |
| US63/261,820 | 2021-09-29 | ||
| PCT/GB2021/052927 WO2022101633A1 (en) | 2020-11-13 | 2021-11-12 | BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TfR1) |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023549229A JP2023549229A (ja) | 2023-11-22 |
| JP2023549229A5 JP2023549229A5 (https=) | 2024-11-21 |
| JPWO2022101633A5 JPWO2022101633A5 (https=) | 2024-11-21 |
| JP7848202B2 true JP7848202B2 (ja) | 2026-04-20 |
Family
ID=81600834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023528449A Active JP7848202B2 (ja) | 2020-11-13 | 2021-11-12 | トランスフェリン受容体１（ＴｆＲ１）に特異的な二環式ペプチドリガンド |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11970555B2 (https=) |
| EP (1) | EP4244235A1 (https=) |
| JP (1) | JP7848202B2 (https=) |
| KR (1) | KR20230107589A (https=) |
| CN (1) | CN116802190A (https=) |
| AR (1) | AR126029A1 (https=) |
| AU (1) | AU2021376917A1 (https=) |
| CA (1) | CA3201414A1 (https=) |
| IL (1) | IL302713A (https=) |
| MX (1) | MX2023005624A (https=) |
| SA (1) | SA523440745B1 (https=) |
| WO (1) | WO2022101633A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL302713A (en) | 2020-11-13 | 2023-07-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1) |
| GB202206431D0 (en) * | 2022-05-03 | 2022-06-15 | Bicycletx Ltd | Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1) |
| KR20260021596A (ko) * | 2023-04-05 | 2026-02-13 | 아이오니스 파마수티컬즈, 인코포레이티드 | Pln 발현을 감소시키는 화합물 및 방법 |
| WO2025073871A1 (en) | 2023-10-03 | 2025-04-10 | Bicycletx Limited | Bicyclic peptide ligand complexes specific for tfr1 |
| GB202316970D0 (en) * | 2023-11-06 | 2023-12-20 | Bicycletx Ltd | Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120172235A1 (en) | 2009-08-12 | 2012-07-05 | Medical Research Council | Peptide libraries |
| WO2018197893A1 (en) | 2017-04-27 | 2018-11-01 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| WO2018197509A1 (en) | 2017-04-24 | 2018-11-01 | Bicyclerd Limited | Modification of polypeptides |
| WO2019089395A1 (en) | 2017-11-02 | 2019-05-09 | Ossianix, Inc. | Improved tfr-selective binding peptides capable of crossing the blood brain barrier |
| WO2019162682A1 (en) | 2018-02-23 | 2019-08-29 | Bicycletx Limited | Multimeric bicyclic peptide ligands |
| WO2020084305A1 (en) | 2018-10-23 | 2020-04-30 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| JP2020529427A (ja) | 2017-08-04 | 2020-10-08 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009211253B2 (en) | 2008-02-05 | 2014-11-06 | Bicyclerd Limited | Methods and compositions |
| WO2016077840A2 (en) * | 2014-11-14 | 2016-05-19 | Ossianix, Inc. | TfR SELECTIVE BINDING COMPOUNDS AND RELATED METHODS |
| CN104650186A (zh) | 2015-03-09 | 2015-05-27 | 中国药科大学 | 一种能够与TfR1特异性结合的活性肽及其应用 |
| JP2022514618A (ja) * | 2018-12-21 | 2022-02-14 | バイスクルテクス・リミテッド | Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド |
| GB201912320D0 (en) * | 2019-08-28 | 2019-10-09 | Bicycletx Ltd | PBP Binding Bicyclic Peptide Ligands |
| IL302713A (en) | 2020-11-13 | 2023-07-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1) |
-
2021
- 2021-11-12 IL IL302713A patent/IL302713A/en unknown
- 2021-11-12 US US17/454,665 patent/US11970555B2/en active Active
- 2021-11-12 KR KR1020237017137A patent/KR20230107589A/ko active Pending
- 2021-11-12 AR ARP210103150A patent/AR126029A1/es unknown
- 2021-11-12 JP JP2023528449A patent/JP7848202B2/ja active Active
- 2021-11-12 WO PCT/GB2021/052927 patent/WO2022101633A1/en not_active Ceased
- 2021-11-12 CA CA3201414A patent/CA3201414A1/en active Pending
- 2021-11-12 AU AU2021376917A patent/AU2021376917A1/en active Pending
- 2021-11-12 EP EP21819173.2A patent/EP4244235A1/en active Pending
- 2021-11-12 CN CN202180089518.5A patent/CN116802190A/zh active Pending
- 2021-11-12 MX MX2023005624A patent/MX2023005624A/es unknown
-
2023
- 2023-05-11 SA SA523440745A patent/SA523440745B1/ar unknown
-
2024
- 2024-03-19 US US18/610,009 patent/US20240391959A1/en not_active Abandoned
-
2025
- 2025-04-23 US US19/187,619 patent/US20250340595A1/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120172235A1 (en) | 2009-08-12 | 2012-07-05 | Medical Research Council | Peptide libraries |
| WO2018197509A1 (en) | 2017-04-24 | 2018-11-01 | Bicyclerd Limited | Modification of polypeptides |
| WO2018197893A1 (en) | 2017-04-27 | 2018-11-01 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| JP2020529427A (ja) | 2017-08-04 | 2020-10-08 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| WO2019089395A1 (en) | 2017-11-02 | 2019-05-09 | Ossianix, Inc. | Improved tfr-selective binding peptides capable of crossing the blood brain barrier |
| WO2019162682A1 (en) | 2018-02-23 | 2019-08-29 | Bicycletx Limited | Multimeric bicyclic peptide ligands |
| WO2020084305A1 (en) | 2018-10-23 | 2020-04-30 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
Non-Patent Citations (3)
| Title |
|---|
| KALE S. Sangram et al.，Cyclization of peptides with two chemical bridges affords large scaffold diversities，nature chemistry，2018年，Vol.10，p.715-723 |
| SANTI Melissa et al.，Rational Design of a Transferrin-Binding Peptide Sequence Tailored to Targeted Nanoparticle Internalization，Bioconjugate Chem，2016年12月01日，Vol.28，p.471-480 |
| XIN Qin et al.，Identification of a Novel Peptide Ligand of Human Transfrrin Receptor 1 for Targeted Tumor Delivery Drug，Protein & Peptide Letters，2013年，Vol.20，p.96-101 |
Also Published As
| Publication number | Publication date |
|---|---|
| US11970555B2 (en) | 2024-04-30 |
| TW202233664A (zh) | 2022-09-01 |
| WO2022101633A1 (en) | 2022-05-19 |
| CA3201414A1 (en) | 2022-05-19 |
| JP2023549229A (ja) | 2023-11-22 |
| MX2023005624A (es) | 2023-05-24 |
| IL302713A (en) | 2023-07-01 |
| KR20230107589A (ko) | 2023-07-17 |
| EP4244235A1 (en) | 2023-09-20 |
| CN116802190A (zh) | 2023-09-22 |
| US20240391959A1 (en) | 2024-11-28 |
| US20220194988A1 (en) | 2022-06-23 |
| AU2021376917A1 (en) | 2023-06-29 |
| SA523440745B1 (ar) | 2024-07-24 |
| US20250340595A1 (en) | 2025-11-06 |
| AR126029A1 (es) | 2023-09-06 |
| AU2021376917A9 (en) | 2024-09-12 |
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