KR20230107589A - 트랜스페린 수용체 1 (TfR1)에 특이적인 비시클릭 펩티드 리간드 - Google Patents

트랜스페린 수용체 1 (TfR1)에 특이적인 비시클릭 펩티드 리간드 Download PDF

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KR20230107589A
KR20230107589A KR1020237017137A KR20237017137A KR20230107589A KR 20230107589 A KR20230107589 A KR 20230107589A KR 1020237017137 A KR1020237017137 A KR 1020237017137A KR 20237017137 A KR20237017137 A KR 20237017137A KR 20230107589 A KR20230107589 A KR 20230107589A
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referred
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isyc
syndrome
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Korean (ko)
Inventor
엘렌 고완스
젬마 머드
마이클 릭비
푸닛 세스
마이클 스키너
스티븐 스탠웨이
리우드비카스 얼보나스
리엣슈텐 케이터린 반
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바이사이클티엑스 리미티드
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Priority claimed from GBGB2017927.1A external-priority patent/GB202017927D0/en
Priority claimed from GBGB2106903.4A external-priority patent/GB202106903D0/en
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Publication of KR20230107589A publication Critical patent/KR20230107589A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020237017137A 2020-11-13 2021-11-12 트랜스페린 수용체 1 (TfR1)에 특이적인 비시클릭 펩티드 리간드 Pending KR20230107589A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB2017927.1 2020-11-13
GBGB2017927.1A GB202017927D0 (en) 2020-11-13 2020-11-13 Bicyclic peptide ligands specific for transferrin
GB2106903.4 2021-05-14
GBGB2106903.4A GB202106903D0 (en) 2021-05-14 2021-05-14 Bicycle peptide ligands specific for transferrin
US202163261820P 2021-09-29 2021-09-29
US63/261,820 2021-09-29
PCT/GB2021/052927 WO2022101633A1 (en) 2020-11-13 2021-11-12 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TfR1)

Publications (1)

Publication Number Publication Date
KR20230107589A true KR20230107589A (ko) 2023-07-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237017137A Pending KR20230107589A (ko) 2020-11-13 2021-11-12 트랜스페린 수용체 1 (TfR1)에 특이적인 비시클릭 펩티드 리간드

Country Status (12)

Country Link
US (3) US11970555B2 (https=)
EP (1) EP4244235A1 (https=)
JP (1) JP7848202B2 (https=)
KR (1) KR20230107589A (https=)
CN (1) CN116802190A (https=)
AR (1) AR126029A1 (https=)
AU (1) AU2021376917A1 (https=)
CA (1) CA3201414A1 (https=)
IL (1) IL302713A (https=)
MX (1) MX2023005624A (https=)
SA (1) SA523440745B1 (https=)
WO (1) WO2022101633A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL302713A (en) 2020-11-13 2023-07-01 Bicycletx Ltd Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1)
GB202206431D0 (en) * 2022-05-03 2022-06-15 Bicycletx Ltd Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1)
KR20260021596A (ko) * 2023-04-05 2026-02-13 아이오니스 파마수티컬즈, 인코포레이티드 Pln 발현을 감소시키는 화합물 및 방법
WO2025073871A1 (en) 2023-10-03 2025-04-10 Bicycletx Limited Bicyclic peptide ligand complexes specific for tfr1
GB202316970D0 (en) * 2023-11-06 2023-12-20 Bicycletx Ltd Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009211253B2 (en) 2008-02-05 2014-11-06 Bicyclerd Limited Methods and compositions
GB0914110D0 (en) * 2009-08-12 2009-09-16 Medical Res Council Peptide libraries
WO2016077840A2 (en) * 2014-11-14 2016-05-19 Ossianix, Inc. TfR SELECTIVE BINDING COMPOUNDS AND RELATED METHODS
CN104650186A (zh) 2015-03-09 2015-05-27 中国药科大学 一种能够与TfR1特异性结合的活性肽及其应用
GB201706477D0 (en) * 2017-04-24 2017-06-07 Bicycle Therapeutics Ltd Modification of polypeptides
WO2018197893A1 (en) 2017-04-27 2018-11-01 Bicycletx Limited Bicyclic peptide ligands and uses thereof
CN111183147B (zh) * 2017-08-04 2024-07-05 拜斯科技术开发有限公司 Cd137特异性的双环肽配体
CA3080351A1 (en) * 2017-11-02 2019-05-09 Ossianix, Inc. Improved tfr-selective binding peptides capable of crossing the blood brain barrier
JP2021514953A (ja) * 2018-02-23 2021-06-17 バイスクルテクス・リミテッド 多量体二環式ペプチドリガンド
WO2020084305A1 (en) * 2018-10-23 2020-04-30 Bicycletx Limited Bicyclic peptide ligands and uses thereof
JP2022514618A (ja) * 2018-12-21 2022-02-14 バイスクルテクス・リミテッド Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド
GB201912320D0 (en) * 2019-08-28 2019-10-09 Bicycletx Ltd PBP Binding Bicyclic Peptide Ligands
IL302713A (en) 2020-11-13 2023-07-01 Bicycletx Ltd Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1)

Also Published As

Publication number Publication date
US11970555B2 (en) 2024-04-30
TW202233664A (zh) 2022-09-01
WO2022101633A1 (en) 2022-05-19
CA3201414A1 (en) 2022-05-19
JP2023549229A (ja) 2023-11-22
MX2023005624A (es) 2023-05-24
JP7848202B2 (ja) 2026-04-20
IL302713A (en) 2023-07-01
EP4244235A1 (en) 2023-09-20
CN116802190A (zh) 2023-09-22
US20240391959A1 (en) 2024-11-28
US20220194988A1 (en) 2022-06-23
AU2021376917A1 (en) 2023-06-29
SA523440745B1 (ar) 2024-07-24
US20250340595A1 (en) 2025-11-06
AR126029A1 (es) 2023-09-06
AU2021376917A9 (en) 2024-09-12

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