CN116670147A - 将lca和3-kca转化为udca和3-kudca的酶促方法 - Google Patents

将lca和3-kca转化为udca和3-kudca的酶促方法 Download PDF

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CN116670147A
CN116670147A CN202180080103.1A CN202180080103A CN116670147A CN 116670147 A CN116670147 A CN 116670147A CN 202180080103 A CN202180080103 A CN 202180080103A CN 116670147 A CN116670147 A CN 116670147A
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leu
ala
gly
val
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Chinese (zh)
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J·G·里德
J·P·雷迪
B·J·保罗
U·谢尔
M·格雷戈里
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Shashan No1 Co ltd
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Shashan No1 Co ltd
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    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
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    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
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    • C12N9/0004—Oxidoreductases (1.)
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    • C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
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    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/14—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (1.14.14)
    • C12Y114/14001—Unspecific monooxygenase (1.14.14.1)

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  • Life Sciences & Earth Sciences (AREA)
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  • Enzymes And Modification Thereof (AREA)
CN202180080103.1A 2020-11-30 2021-11-29 将lca和3-kca转化为udca和3-kudca的酶促方法 Pending CN116670147A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063119188P 2020-11-30 2020-11-30
US63/119,188 2020-11-30
PCT/US2021/061025 WO2022115710A1 (en) 2020-11-30 2021-11-29 Enzymatic methods for converting lca and 3-kca to udca and 3-kudca

Publications (1)

Publication Number Publication Date
CN116670147A true CN116670147A (zh) 2023-08-29

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ID=81754944

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CN202180080103.1A Pending CN116670147A (zh) 2020-11-30 2021-11-29 将lca和3-kca转化为udca和3-kudca的酶促方法

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Country Link
US (1) US20230416800A1 (https=)
EP (1) EP4251169A4 (https=)
JP (1) JP2023552528A (https=)
KR (1) KR20230116864A (https=)
CN (1) CN116670147A (https=)
AU (1) AU2021385425A1 (https=)
CA (1) CA3201311A1 (https=)
WO (1) WO2022115710A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4665352A2 (en) * 2023-02-14 2025-12-24 Epimeron USA, Inc. Recombinant polypeptides for biosynthesis of ursodeoxycholic acid (udca)
CN117025709A (zh) * 2023-07-31 2023-11-10 华南理工大学 一种细胞色素p450酶联合细胞色素p450还原酶在合成熊去氧胆酸中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58155098A (ja) * 1982-03-09 1983-09-14 Yakult Honsha Co Ltd 微生物によるウルソデオキシコ−ル酸の製造法
US5989855A (en) * 1996-03-29 1999-11-23 Tokyo Tanabe Company Limited Bile acid converting microorganism and process for preparing bile acid
WO2013086499A2 (en) * 2011-12-09 2013-06-13 Ceres, Inc. Transgenic plants having altered biomass composition
EP3444340B1 (de) * 2014-07-29 2020-04-15 Pharmazell GmbH 7beta-hydroxysteroid dehydrogenase-mutanten und verfahren zur herstellung von ursodesoxycholsäure
IT201900017411A1 (it) * 2019-09-27 2021-03-27 Ice S P A Processo di preparazione di acido ursodesossicolico

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CA3201311A1 (en) 2022-06-02
US20230416800A1 (en) 2023-12-28
JP2023552528A (ja) 2023-12-18
AU2021385425A9 (en) 2025-01-09
WO2022115710A1 (en) 2022-06-02
KR20230116864A (ko) 2023-08-04
EP4251169A1 (en) 2023-10-04
AU2021385425A1 (en) 2023-06-15
EP4251169A4 (en) 2025-07-09

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