CN1166363C - 莫索尼定在制备治疗心肌梗塞造成的心肌损伤的药物中的应用 - Google Patents
莫索尼定在制备治疗心肌梗塞造成的心肌损伤的药物中的应用 Download PDFInfo
- Publication number
- CN1166363C CN1166363C CNB008032440A CN00803244A CN1166363C CN 1166363 C CN1166363 C CN 1166363C CN B008032440 A CNB008032440 A CN B008032440A CN 00803244 A CN00803244 A CN 00803244A CN 1166363 C CN1166363 C CN 1166363C
- Authority
- CN
- China
- Prior art keywords
- myocardial infarction
- moxonidine
- treatment
- rat
- heart
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Details Of Spanners, Wrenches, And Screw Drivers And Accessories (AREA)
- Heat Treatment Of Articles (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fire-Extinguishing Compositions (AREA)
- Farming Of Fish And Shellfish (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Description
SHAM | INFARKT | INF+MOX(3mg) | INF+MOX(6mg) | |
试验动物数体重(g)心脏重(mg)心脏重/体重比心率(次/分钟)MAP(mmHg) | 8-14333±71174±373,5±0.1351±17111±2 | 7-12320±101543±75*4,7±0.3*387±8*98±3* | 7301±51408±1044,7±0.4*334±12#87±3* | 6-7299±9*1076±24#3,6±0,2#321±6*#100±5 |
血浆NA-水平(pg/ml)血浆ANF(pg/ml)间质的胶原蛋白(%) | 199±3038±31,3±0,1 | 578±143*53±52,2±0,3* | 345±108(54±2,n-3)2,4±0,2* | 96±20#61±81,4±0,1 |
Claims (3)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19903780 | 1999-02-01 | ||
DE19903780.9 | 1999-02-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1338938A CN1338938A (zh) | 2002-03-06 |
CN1166363C true CN1166363C (zh) | 2004-09-15 |
Family
ID=7895940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008032440A Expired - Fee Related CN1166363C (zh) | 1999-02-01 | 2000-01-28 | 莫索尼定在制备治疗心肌梗塞造成的心肌损伤的药物中的应用 |
Country Status (26)
Country | Link |
---|---|
US (1) | US7041303B2 (zh) |
EP (1) | EP1150680B1 (zh) |
JP (1) | JP4686027B2 (zh) |
KR (1) | KR20010092793A (zh) |
CN (1) | CN1166363C (zh) |
AT (1) | ATE286731T1 (zh) |
AU (1) | AU774855B2 (zh) |
BR (1) | BR0007894A (zh) |
CA (1) | CA2361600C (zh) |
CZ (1) | CZ20012615A3 (zh) |
DE (2) | DE10003771A1 (zh) |
DK (1) | DK1150680T3 (zh) |
ES (1) | ES2235829T3 (zh) |
HK (1) | HK1042650B (zh) |
HU (1) | HUP0105210A3 (zh) |
IL (1) | IL144621A (zh) |
NO (1) | NO321061B1 (zh) |
NZ (1) | NZ513869A (zh) |
PL (1) | PL195124B1 (zh) |
PT (1) | PT1150680E (zh) |
RU (1) | RU2261097C2 (zh) |
SK (1) | SK10082001A3 (zh) |
TR (1) | TR200102221T2 (zh) |
UA (1) | UA67822C2 (zh) |
WO (1) | WO2000045820A1 (zh) |
ZA (1) | ZA200105827B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102850331B (zh) * | 2012-09-17 | 2015-05-20 | 符爱清 | 一种化合物的制备方法 |
CN103483268B (zh) * | 2013-09-17 | 2015-10-14 | 常州大学 | 一种4,6-二氯-2-甲基-5-硝基嘧啶的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3739779A1 (de) * | 1987-11-24 | 1989-06-08 | Beiersdorf Ag | Pharmazeutische praeparate |
AU3233197A (en) * | 1996-06-06 | 1998-01-05 | Eli Lilly And Company | Formulation and method for treating congestive heart failure |
-
2000
- 2000-01-28 NZ NZ513869A patent/NZ513869A/xx unknown
- 2000-01-28 JP JP2000596940A patent/JP4686027B2/ja not_active Expired - Fee Related
- 2000-01-28 CZ CZ20012615A patent/CZ20012615A3/cs unknown
- 2000-01-28 SK SK1008-2001A patent/SK10082001A3/sk unknown
- 2000-01-28 CN CNB008032440A patent/CN1166363C/zh not_active Expired - Fee Related
- 2000-01-28 IL IL14462100A patent/IL144621A/en not_active IP Right Cessation
- 2000-01-28 PT PT00902638T patent/PT1150680E/pt unknown
- 2000-01-28 TR TR2001/02221T patent/TR200102221T2/xx unknown
- 2000-01-28 AT AT00902638T patent/ATE286731T1/de not_active IP Right Cessation
- 2000-01-28 DK DK00902638T patent/DK1150680T3/da active
- 2000-01-28 UA UA2001075408A patent/UA67822C2/uk unknown
- 2000-01-28 BR BR0007894-8A patent/BR0007894A/pt not_active IP Right Cessation
- 2000-01-28 EP EP00902638A patent/EP1150680B1/de not_active Expired - Lifetime
- 2000-01-28 KR KR1020017009232A patent/KR20010092793A/ko not_active Application Discontinuation
- 2000-01-28 DE DE10003771A patent/DE10003771A1/de not_active Withdrawn
- 2000-01-28 HU HU0105210A patent/HUP0105210A3/hu unknown
- 2000-01-28 CA CA002361600A patent/CA2361600C/en not_active Expired - Fee Related
- 2000-01-28 ES ES00902638T patent/ES2235829T3/es not_active Expired - Lifetime
- 2000-01-28 AU AU24404/00A patent/AU774855B2/en not_active Ceased
- 2000-01-28 DE DE50009220T patent/DE50009220D1/de not_active Expired - Lifetime
- 2000-01-28 RU RU2001121019/14A patent/RU2261097C2/ru not_active IP Right Cessation
- 2000-01-28 PL PL00350559A patent/PL195124B1/pl not_active IP Right Cessation
- 2000-01-28 WO PCT/EP2000/000655 patent/WO2000045820A1/de not_active Application Discontinuation
-
2001
- 2001-07-16 ZA ZA200105827A patent/ZA200105827B/en unknown
- 2001-07-31 NO NO20013753A patent/NO321061B1/no unknown
- 2001-07-31 US US09/917,858 patent/US7041303B2/en not_active Expired - Fee Related
-
2002
- 2002-05-31 HK HK02104090.9A patent/HK1042650B/zh not_active IP Right Cessation
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Address after: Hannover Patentee after: Solvay Pharm GmbH Address before: Hannover Patentee before: Solvay Pharmaceuticals GmbH |
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Owner name: ABBOTT LABORATORIES CO., LTD. Free format text: FORMER OWNER: ABBOTT PRODUCTS, INC. Effective date: 20130304 |
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Effective date of registration: 20130304 Address after: Hannover Patentee after: Abbott Laboratories Co., Ltd. Address before: Hannover Patentee before: Solvay Pharm GmbH |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040915 Termination date: 20140128 |