CN116568800A - 生物体的操作方法及操作装置 - Google Patents

生物体的操作方法及操作装置 Download PDF

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Publication number
CN116568800A
CN116568800A CN202180078720.8A CN202180078720A CN116568800A CN 116568800 A CN116568800 A CN 116568800A CN 202180078720 A CN202180078720 A CN 202180078720A CN 116568800 A CN116568800 A CN 116568800A
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CN
China
Prior art keywords
flow path
nozzle
gas
liquid
liquid interface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180078720.8A
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English (en)
Chinese (zh)
Inventor
森山真树
石泽直也
小林辽
中村太一
田中修平
林世莉
田洼牧子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nikon Corp
Original Assignee
Nikon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikon Corp filed Critical Nikon Corp
Publication of CN116568800A publication Critical patent/CN116568800A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN202180078720.8A 2020-09-24 2021-09-24 生物体的操作方法及操作装置 Pending CN116568800A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020160241 2020-09-24
JP2020-160241 2020-09-24
PCT/JP2021/035209 WO2022065460A1 (ja) 2020-09-24 2021-09-24 生物体の操作方法および操作装置

Publications (1)

Publication Number Publication Date
CN116568800A true CN116568800A (zh) 2023-08-08

Family

ID=80846683

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180078720.8A Pending CN116568800A (zh) 2020-09-24 2021-09-24 生物体的操作方法及操作装置

Country Status (5)

Country Link
US (1) US20240279583A1 (https=)
EP (1) EP4219676A4 (https=)
JP (1) JPWO2022065460A1 (https=)
CN (1) CN116568800A (https=)
WO (1) WO2022065460A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4624561A1 (en) * 2022-10-21 2025-10-01 Nikon Corporation Channel member and fine object manipulation device

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0715440Y2 (ja) * 1989-09-21 1995-04-12 株式会社ツムラ 反応容器
JP3326881B2 (ja) 1993-06-25 2002-09-24 株式会社ニコン 走査型光学顕微鏡
JP3814869B2 (ja) 1996-05-14 2006-08-30 株式会社ニコン 共焦点レーザ走査顕微鏡
DE10110213B4 (de) * 2001-03-04 2006-12-21 Sita Messtechnik Gmbh Kapillare und Messvorrichtung zum Bestimmen der Oberflächen- bzw. Grenzflächenspannung einer Flüssigkeit
DE102005007870B4 (de) * 2005-02-21 2007-12-06 E.G.O. Elektro-Gerätebau GmbH Verfahren und Vorrichtung zum Messen der Oberflächenspannung von Flüssigkeiten
DE102007056669A1 (de) * 2007-11-24 2009-05-28 Krüss GmbH, Wissenschaftliche Laborgeräte Verfahren und Gerät zur schnellen Bildung von Fluidgrenzflächen und Verwendung dieses Geräts zur Bestimmung von Flüssig-flüssig- und Flüssig-Gas-Grenzflächeneigenschaften
WO2012158631A2 (en) * 2011-05-13 2012-11-22 The Regents Of The University Of California Photothermal substrates for selective transfection of cells
JP6422889B2 (ja) * 2013-12-27 2018-11-14 積水化学工業株式会社 細胞の剥離方法、細胞支持用基材、並びに、細胞の培養方法
JP6066110B2 (ja) 2014-06-11 2017-01-25 横河電機株式会社 細胞吸引支援システム
US10456779B2 (en) * 2015-03-16 2019-10-29 Panasonic Corporation Pipette tip having a straight pipe section with inner protrusion and pipetting method for a liquid including cells
US12504353B2 (en) * 2019-03-25 2025-12-23 Nikon Corporation Cell manipulation device and cell manipulation method

Also Published As

Publication number Publication date
EP4219676A4 (en) 2025-05-21
US20240279583A1 (en) 2024-08-22
WO2022065460A1 (ja) 2022-03-31
EP4219676A1 (en) 2023-08-02
JPWO2022065460A1 (https=) 2022-03-31

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