CN116528892A - 用于眼部适应症的载体化抗TNF-α抗体 - Google Patents

用于眼部适应症的载体化抗TNF-α抗体 Download PDF

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Publication number
CN116528892A
CN116528892A CN202180072573.3A CN202180072573A CN116528892A CN 116528892 A CN116528892 A CN 116528892A CN 202180072573 A CN202180072573 A CN 202180072573A CN 116528892 A CN116528892 A CN 116528892A
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China
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seq
amino acid
acid sequence
aav
light chain
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Chinese (zh)
Inventor
X·王
D·麦克多加尔德
J·布鲁德尔
Y·刘
O·达诺斯
W-H·李
C·乔
E·布德津斯基
M·赫格斯
M·石
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Bio Regeneration Co ltd
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Bio Regeneration Co ltd
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Publication of CN116528892A publication Critical patent/CN116528892A/zh
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C12N2710/00011—Details
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    • C12N2710/10011—Adenoviridae
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145—Special targeting system for viral vectors

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Wood Science & Technology (AREA)
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  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202180072573.3A 2020-10-28 2021-10-28 用于眼部适应症的载体化抗TNF-α抗体 Pending CN116528892A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063106832P 2020-10-28 2020-10-28
US63/106,832 2020-10-28
PCT/US2021/057084 WO2022094106A1 (en) 2020-10-28 2021-10-28 VECTORIZED ANTI-TNF-α ANTIBODIES FOR OCULAR INDICATIONS

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Publication Number Publication Date
CN116528892A true CN116528892A (zh) 2023-08-01

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CN202180072573.3A Pending CN116528892A (zh) 2020-10-28 2021-10-28 用于眼部适应症的载体化抗TNF-α抗体

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US (1) US20230391864A1 (https=)
EP (1) EP4236999A1 (https=)
JP (1) JP2023547832A (https=)
KR (1) KR20230093437A (https=)
CN (1) CN116528892A (https=)
AR (1) AR123948A1 (https=)
AU (1) AU2021371307A1 (https=)
CA (1) CA3195967A1 (https=)
IL (1) IL302279A (https=)
MX (1) MX2023004806A (https=)
TW (1) TW202233841A (https=)
WO (1) WO2022094106A1 (https=)

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MX2023004806A (es) 2023-05-10
WO2022094106A1 (en) 2022-05-05
KR20230093437A (ko) 2023-06-27
US20230391864A1 (en) 2023-12-07
AR123948A1 (es) 2023-01-25
JP2023547832A (ja) 2023-11-14
AU2021371307A9 (en) 2024-09-19
EP4236999A1 (en) 2023-09-06
CA3195967A1 (en) 2022-05-05
AU2021371307A1 (en) 2023-06-01
IL302279A (en) 2023-06-01
TW202233841A (zh) 2022-09-01

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