CN116528892A - 用于眼部适应症的载体化抗TNF-α抗体 - Google Patents

用于眼部适应症的载体化抗TNF-α抗体 Download PDF

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Publication number
CN116528892A
CN116528892A CN202180072573.3A CN202180072573A CN116528892A CN 116528892 A CN116528892 A CN 116528892A CN 202180072573 A CN202180072573 A CN 202180072573A CN 116528892 A CN116528892 A CN 116528892A
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China
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seq
amino acid
acid sequence
aav
light chain
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Chinese (zh)
Inventor
X·王
D·麦克多加尔德
J·布鲁德尔
Y·刘
O·达诺斯
W-H·李
C·乔
E·布德津斯基
M·赫格斯
M·石
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Bio Regeneration Co ltd
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Bio Regeneration Co ltd
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Publication of CN116528892A publication Critical patent/CN116528892A/zh
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
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    • C12N2710/10011—Adenoviridae
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145—Special targeting system for viral vectors

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  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
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  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202180072573.3A 2020-10-28 2021-10-28 用于眼部适应症的载体化抗TNF-α抗体 Pending CN116528892A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063106832P 2020-10-28 2020-10-28
US63/106,832 2020-10-28
PCT/US2021/057084 WO2022094106A1 (en) 2020-10-28 2021-10-28 VECTORIZED ANTI-TNF-α ANTIBODIES FOR OCULAR INDICATIONS

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Publication Number Publication Date
CN116528892A true CN116528892A (zh) 2023-08-01

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CN202180072573.3A Pending CN116528892A (zh) 2020-10-28 2021-10-28 用于眼部适应症的载体化抗TNF-α抗体

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US (1) US20230391864A1 (enExample)
EP (1) EP4236999A1 (enExample)
JP (1) JP2023547832A (enExample)
KR (1) KR20230093437A (enExample)
CN (1) CN116528892A (enExample)
AR (1) AR123948A1 (enExample)
AU (1) AU2021371307A1 (enExample)
CA (1) CA3195967A1 (enExample)
IL (1) IL302279A (enExample)
MX (1) MX2023004806A (enExample)
TW (1) TW202233841A (enExample)
WO (1) WO2022094106A1 (enExample)

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AU2021371307A9 (en) 2024-09-19
JP2023547832A (ja) 2023-11-14
IL302279A (en) 2023-06-01
CA3195967A1 (en) 2022-05-05
WO2022094106A1 (en) 2022-05-05
AR123948A1 (es) 2023-01-25
TW202233841A (zh) 2022-09-01
AU2021371307A1 (en) 2023-06-01
KR20230093437A (ko) 2023-06-27
EP4236999A1 (en) 2023-09-06
US20230391864A1 (en) 2023-12-07
MX2023004806A (es) 2023-05-10

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