JP2023547832A - 眼の適応症に対するベクター化抗ＴＮＦ－α抗体 - Google Patents

眼の適応症に対するベクター化抗ＴＮＦ－α抗体 Download PDF

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JP2023547832A
JP2023547832A JP2023524162A JP2023524162A JP2023547832A JP 2023547832 A JP2023547832 A JP 2023547832A JP 2023524162 A JP2023524162 A JP 2023524162A JP 2023524162 A JP2023524162 A JP 2023524162A JP 2023547832 A JP2023547832 A JP 2023547832A
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seq
amino acid
acid sequence
light chain
encoding
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JP2023547832A5 (enExample
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ワン，シュー
マクドゥーガルド，デヴィン
ブルーダー，ジョセフ
リウ，イェ
ダノス，オリビエ
リー，ウェイ－ファ
チャオ，チャンピング
バドジンスキ，エワ
ヒギンス，ミカイラ
シ，ミ
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リジェネックスバイオ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C—CHEMISTRY; METALLURGY
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145—Special targeting system for viral vectors

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  • Wood Science & Technology (AREA)
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  • Plant Pathology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2023524162A 2020-10-28 2021-10-28 眼の適応症に対するベクター化抗ＴＮＦ－α抗体 Pending JP2023547832A (ja)

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US202063106832P 2020-10-28 2020-10-28
US63/106,832 2020-10-28
PCT/US2021/057084 WO2022094106A1 (en) 2020-10-28 2021-10-28 VECTORIZED ANTI-TNF-α ANTIBODIES FOR OCULAR INDICATIONS

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JP2023547832A5 JP2023547832A5 (enExample) 2024-10-29

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EP (1) EP4236999A1 (enExample)
JP (1) JP2023547832A (enExample)
KR (1) KR20230093437A (enExample)
CN (1) CN116528892A (enExample)
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AU (1) AU2021371307A1 (enExample)
CA (1) CA3195967A1 (enExample)
IL (1) IL302279A (enExample)
MX (1) MX2023004806A (enExample)
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AU2023250660A1 (en) * 2022-04-06 2024-10-24 Regenxbio Inc. Pharmaceutical composition comprising a recombinant adenoassociated virus vector with an expression cassette encoding a transgene for suprachoroidal administration
US20250375536A1 (en) * 2022-07-01 2025-12-11 The University Of Bristol Vector
WO2024118610A2 (en) * 2022-11-28 2024-06-06 Siren Biotechnology, Inc. Gene therapy vectors for treatment of cancer

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EP4236999A1 (en) 2023-09-06
IL302279A (en) 2023-06-01
CN116528892A (zh) 2023-08-01
KR20230093437A (ko) 2023-06-27
WO2022094106A1 (en) 2022-05-05
AU2021371307A9 (en) 2024-09-19
AU2021371307A1 (en) 2023-06-01
AR123948A1 (es) 2023-01-25
CA3195967A1 (en) 2022-05-05
US20230391864A1 (en) 2023-12-07
MX2023004806A (es) 2023-05-10

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