IL134643A0 - Chimeric transcriptional activators and compositions and uses related thereto - Google Patents

Chimeric transcriptional activators and compositions and uses related thereto

Info

Publication number
IL134643A0
IL134643A0 IL13464397A IL13464397A IL134643A0 IL 134643 A0 IL134643 A0 IL 134643A0 IL 13464397 A IL13464397 A IL 13464397A IL 13464397 A IL13464397 A IL 13464397A IL 134643 A0 IL134643 A0 IL 134643A0
Authority
IL
Israel
Prior art keywords
compositions
transcriptional activators
uses related
chimeric transcriptional
chimeric
Prior art date
Application number
IL13464397A
Original Assignee
Ariad Gene Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ariad Gene Therapeutics Inc filed Critical Ariad Gene Therapeutics Inc
Publication of IL134643A0 publication Critical patent/IL134643A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression

Landscapes

  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL13464397A 1997-08-27 1997-08-27 Chimeric transcriptional activators and compositions and uses related thereto IL134643A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1997/015219 WO1999010508A1 (en) 1997-08-27 1997-08-27 Chimeric transcriptional activators and compositions and uses related thereto

Publications (1)

Publication Number Publication Date
IL134643A0 true IL134643A0 (en) 2001-04-30

Family

ID=22261527

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13464397A IL134643A0 (en) 1997-08-27 1997-08-27 Chimeric transcriptional activators and compositions and uses related thereto

Country Status (6)

Country Link
EP (1) EP1003886A1 (en)
JP (1) JP2001514007A (en)
AU (1) AU752129B2 (en)
CA (1) CA2303482A1 (en)
IL (1) IL134643A0 (en)
WO (1) WO1999010508A1 (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2375490A1 (en) * 1999-06-18 2000-12-28 Ariad Gene Therapeutics, Inc. Chimeric oca-b transcription factors
CA2398010A1 (en) 2000-01-24 2001-07-26 The Trustees Of Columbia University In The City Of New York An in vivo screen using chemical inducers of dimerization
WO2001062780A1 (en) * 2000-02-24 2001-08-30 The Salk Institute For Biological Studies Gene expression system based on chimeric receptors
AU2000256183A1 (en) * 2000-06-16 2002-01-02 Ariad Gene Therapeutics, Inc. Chimeric hsf transcription factors
MXPA03007492A (en) * 2001-02-20 2004-10-15 Rheogene Holdings Inc Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system.
EP1435779A4 (en) 2001-09-24 2005-06-01 Sangamo Biosciences Inc Modulation of stem cells using zinc finger proteins
US7083918B2 (en) 2002-04-24 2006-08-01 The Trustees Of Columbia University In The City Of New York Bacterial small-molecule three-hybrid system
AU2004274957B2 (en) 2003-09-19 2009-02-05 Sangamo Therapeutics, Inc. Engineered zinc finger proteins for regulation of gene expression
WO2006033859A2 (en) 2004-09-16 2006-03-30 Sangamo Biosciences, Inc. Compositions and methods for protein production
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
CA2793633A1 (en) 2010-03-29 2011-10-13 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
EP2699688A1 (en) 2011-04-20 2014-02-26 The Trustees Of The University Of Pennsylvania Regimens and compositions for aav-mediated passive immunization of airborne pathogens
WO2016200543A2 (en) 2015-05-13 2016-12-15 The Trustees Of The University Of Pennsylvania Aav-mediated expression of anti-inluenza antibodies and methods of use thereof
SG11201808426XA (en) 2016-04-15 2018-10-30 Univ Pennsylvania Compositions for treatment of wet age-related macular degeneration
JOP20190200A1 (en) 2017-02-28 2019-08-27 Univ Pennsylvania Compositions useful in treatment of spinal muscular atrophy
SG11201907611WA (en) 2017-02-28 2019-09-27 Univ Pennsylvania Influenza vaccines based on aav vectors
HRP20240257T1 (en) 2017-02-28 2024-05-24 The Trustees Of The University Of Pennsylvania Adeno-associated virus (aav) clade f vector and uses therefor
SG11202003479TA (en) 2017-10-18 2020-05-28 Regenxbio Inc Fully-human post-translationally modified antibody therapeutics
CA3079565A1 (en) 2017-10-18 2019-04-25 Regenxbio Inc. Treatment of ocular diseases and metastatic colon cancer with human post-translationally modified vegf-trap
CN113966236A (en) 2019-04-03 2022-01-21 再生生物股份有限公司 Gene therapy for ocular conditions
TW202106708A (en) 2019-04-24 2021-02-16 美商銳進科斯生物股份有限公司 Fully-human post-translationally modified antibody therapeutics
JP2022545967A (en) 2019-08-26 2022-11-01 リジェネックスバイオ インコーポレイテッド Treatment of diabetic retinopathy with a fully human post-translationally modified anti-VEGF Fab
KR20220081365A (en) 2019-10-07 2022-06-15 리젠엑스바이오 인크. Adeno-associated virus vector pharmaceutical compositions and methods
EP4214242A1 (en) 2020-09-15 2023-07-26 RegenxBio Inc. Vectorized antibodies for anti-viral therapy
EP4213890A1 (en) 2020-09-15 2023-07-26 RegenxBio Inc. Vectorized lanadelumab and administration thereof
CA3197342A1 (en) 2020-10-07 2022-04-14 Regenxbio Inc. Gene therapy for ocular manifestations of cln2 disease
CN116528892A (en) 2020-10-28 2023-08-01 再生生物股份有限公司 Supported anti-TNF-alpha antibodies for ocular indications
WO2022094157A1 (en) 2020-10-28 2022-05-05 Regenxbio Inc. Vectorized anti-cgrp and anti-cgrpr antibodies and administration thereof
WO2022094255A2 (en) 2020-10-29 2022-05-05 Regenxbio Inc. Vectorized factor xii antibodies and administration thereof
AU2021369833A1 (en) 2020-10-29 2023-06-08 Regenxbio Inc. Vectorized tnf-alpha antagonists for ocular indications
TW202237850A (en) 2020-12-01 2022-10-01 賓州大學委員會 Novel compositions with tissue-specific targeting motifs and compositions containing same
CN112661820B (en) * 2020-12-31 2021-12-14 中国科学院天津工业生物技术研究所 Rhizobium tianshanense transcription regulation protein MsiR mutant protein and application thereof in canavanine biosensor
AR125406A1 (en) 2021-04-23 2023-07-12 Univ Pennsylvania NEW COMPOSITIONS WITH SELECTIVE MOTIVES FOR THE BRAIN AND COMPOSITIONS CONTAINING THEM
TW202325845A (en) 2021-10-02 2023-07-01 賓州大學委員會 Novel aav capsids and compositions containing same
WO2023147304A1 (en) 2022-01-25 2023-08-03 The Trustees Of The University Of Pennsylvania Aav capsids for improved heart transduction and detargeting of liver
WO2023201308A1 (en) 2022-04-14 2023-10-19 Regenxbio Inc. Gene therapy for treating an ocular disease
WO2023205610A2 (en) 2022-04-18 2023-10-26 Regenxbio Inc. Hybrid aav capsids
WO2023215806A2 (en) 2022-05-03 2023-11-09 Regenxbio Inc. Vectorized anti-complement antibodies and complement agents and administration thereof
WO2023215807A1 (en) 2022-05-03 2023-11-09 Regenxbio Inc. VECTORIZED ANTI-TNF-α INHIBITORS FOR OCULAR INDICATIONS
WO2024022474A1 (en) * 2022-07-29 2024-02-01 南京百斯杰生物工程有限公司 Chimeric transcriptional activator and use thereof
WO2024073669A1 (en) 2022-09-30 2024-04-04 Regenxbio Inc. Treatment of ocular diseases with recombinant viral vectors encoding anti-vegf fab

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0882128A1 (en) * 1996-02-23 1998-12-09 Ariad Pharmaceuticals, Inc. Cell-based assay
WO1997044447A2 (en) * 1996-05-03 1997-11-27 President And Fellows Of Harvard College Transcriptional activation system, activators, and uses therefor

Also Published As

Publication number Publication date
EP1003886A1 (en) 2000-05-31
AU4240297A (en) 1999-03-16
JP2001514007A (en) 2001-09-11
CA2303482A1 (en) 1999-03-04
AU752129B2 (en) 2002-09-05
WO1999010508A1 (en) 1999-03-04

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