CN116507364A - 组合物 - Google Patents

组合物 Download PDF

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Publication number
CN116507364A
CN116507364A CN202180069896.7A CN202180069896A CN116507364A CN 116507364 A CN116507364 A CN 116507364A CN 202180069896 A CN202180069896 A CN 202180069896A CN 116507364 A CN116507364 A CN 116507364A
Authority
CN
China
Prior art keywords
compound
group
antibody
polymer
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180069896.7A
Other languages
English (en)
Chinese (zh)
Inventor
佐久间信至
伴野拓巳
宫田康平
滋野浩一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adeka Corp
Josho Gakuen Educational Foundation
Original Assignee
Adeka Corp
Josho Gakuen Educational Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adeka Corp, Josho Gakuen Educational Foundation filed Critical Adeka Corp
Publication of CN116507364A publication Critical patent/CN116507364A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/36—Amides or imides
    • C08F222/38—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN202180069896.7A 2020-10-16 2021-10-11 组合物 Pending CN116507364A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020174704 2020-10-16
JP2020-174704 2020-10-16
PCT/JP2021/037523 WO2022080294A1 (ja) 2020-10-16 2021-10-11 組成物

Publications (1)

Publication Number Publication Date
CN116507364A true CN116507364A (zh) 2023-07-28

Family

ID=81208159

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180069896.7A Pending CN116507364A (zh) 2020-10-16 2021-10-11 组合物

Country Status (6)

Country Link
US (1) US20230383037A1 (https=)
EP (1) EP4230223A4 (https=)
JP (1) JPWO2022080294A1 (https=)
KR (1) KR20230090333A (https=)
CN (1) CN116507364A (https=)
WO (1) WO2022080294A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010100781A (ja) * 2008-10-27 2010-05-06 Josho Gakuen 高分子、経上皮吸収促進剤、及び医薬用製剤
JP2011229495A (ja) * 2010-04-30 2011-11-17 Adeka Corp 細胞への水溶性高分子量物質の導入方法及び導入剤
CN107207565A (zh) * 2015-02-27 2017-09-26 学校法人常翔学园 侧链具有膜透过性肽的高分子化合物
WO2020013265A1 (ja) * 2018-07-11 2020-01-16 学校法人常翔学園 高分子化合物及びそれを用いた細胞内化合物導入促進剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4099831B2 (ja) 1994-07-14 2008-06-11 昭和電工株式会社 高重合性ｎ−ビニルカルボン酸アミドおよびその製造方法
BRPI0716539A2 (pt) 2006-09-07 2016-11-01 Emisphere Tech Inc métodos para sintetização de ácido n-(8-[2-hidroxibenzoil]amino) caprílico e de sal de sódio deste
RU2548807C2 (ru) 2009-05-20 2015-04-20 Торэй Индастриз, Инк. Пептиды, проникающие в клетку
CN107207627B (zh) * 2015-02-27 2022-05-24 学校法人常翔学园 具有膜透过性肽链的多糖衍生物
US10918727B2 (en) 2016-04-06 2021-02-16 Icure Bnp Co., Ltd. Peptide with ability to penetrate cell membrane

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010100781A (ja) * 2008-10-27 2010-05-06 Josho Gakuen 高分子、経上皮吸収促進剤、及び医薬用製剤
JP2011229495A (ja) * 2010-04-30 2011-11-17 Adeka Corp 細胞への水溶性高分子量物質の導入方法及び導入剤
CN107207565A (zh) * 2015-02-27 2017-09-26 学校法人常翔学园 侧链具有膜透过性肽的高分子化合物
WO2020013265A1 (ja) * 2018-07-11 2020-01-16 学校法人常翔学園 高分子化合物及びそれを用いた細胞内化合物導入促進剤

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SHINJI SAKUMA等: "Cross-reactivity of immunoglobulin A secreted on the nasal mucosa in mice nasally inoculated with inactivated H1N1 influenza A viruses in the presence of D-octaarginine-linked polymers", 《EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS》, vol. 92, 23 February 2015 (2015-02-23), pages 56 - 64 *
SHINJI SAKUMA等: "Oligoarginine-linked polymers as a new class of penetration enhancers", 《JOURNAL OF CONTROLLED RELEASE》, vol. 148, no. 2, 31 December 2010 (2010-12-31), pages 187 - 196 *
张吉林等主编: "《医学分子生物学实验指导》", vol. 1, 30 September 2005, 中国医药科技出版社, pages: 182 *

Also Published As

Publication number Publication date
US20230383037A1 (en) 2023-11-30
KR20230090333A (ko) 2023-06-21
EP4230223A1 (en) 2023-08-23
JPWO2022080294A1 (https=) 2022-04-21
EP4230223A4 (en) 2025-03-05
WO2022080294A1 (ja) 2022-04-21

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