CN116496279B - 同位素标记的曲匹地尔衍生物 - Google Patents

同位素标记的曲匹地尔衍生物

Info

Publication number
CN116496279B
CN116496279B CN202310374367.9A CN202310374367A CN116496279B CN 116496279 B CN116496279 B CN 116496279B CN 202310374367 A CN202310374367 A CN 202310374367A CN 116496279 B CN116496279 B CN 116496279B
Authority
CN
China
Prior art keywords
therapeutic agent
additional therapeutic
pharmaceutically acceptable
solvate
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202310374367.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN116496279A (zh
Inventor
阿拉什·伯德巴尔
正宗宽子
沃伦·S·韦德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sinopia Biosciences Inc
Original Assignee
Sinopia Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinopia Biosciences Inc filed Critical Sinopia Biosciences Inc
Publication of CN116496279A publication Critical patent/CN116496279A/zh
Application granted granted Critical
Publication of CN116496279B publication Critical patent/CN116496279B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
CN202310374367.9A 2020-03-26 2021-03-25 同位素标记的曲匹地尔衍生物 Active CN116496279B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202063000347P 2020-03-26 2020-03-26
US63/000,347 2020-03-26
US202063063846P 2020-08-10 2020-08-10
US63/063,846 2020-08-10
CN202180038452.7A CN115916180A (zh) 2020-03-26 2021-03-25 同位素标记的曲匹地尔衍生物
PCT/US2021/024226 WO2021195425A1 (en) 2020-03-26 2021-03-25 Isotopically-labelled trapidil derivatives

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202180038452.7A Division CN115916180A (zh) 2020-03-26 2021-03-25 同位素标记的曲匹地尔衍生物

Publications (2)

Publication Number Publication Date
CN116496279A CN116496279A (zh) 2023-07-28
CN116496279B true CN116496279B (zh) 2025-12-12

Family

ID=77892379

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202310374367.9A Active CN116496279B (zh) 2020-03-26 2021-03-25 同位素标记的曲匹地尔衍生物
CN202511776120.5A Pending CN121550230A (zh) 2020-03-26 2021-03-25 同位素标记的曲匹地尔衍生物
CN202180038452.7A Pending CN115916180A (zh) 2020-03-26 2021-03-25 同位素标记的曲匹地尔衍生物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202511776120.5A Pending CN121550230A (zh) 2020-03-26 2021-03-25 同位素标记的曲匹地尔衍生物
CN202180038452.7A Pending CN115916180A (zh) 2020-03-26 2021-03-25 同位素标记的曲匹地尔衍生物

Country Status (11)

Country Link
US (1) US12508267B2 (cg-RX-API-DMAC10.html)
EP (1) EP4125853A4 (cg-RX-API-DMAC10.html)
JP (2) JP7730336B2 (cg-RX-API-DMAC10.html)
KR (1) KR20230013023A (cg-RX-API-DMAC10.html)
CN (3) CN116496279B (cg-RX-API-DMAC10.html)
AU (1) AU2021244241A1 (cg-RX-API-DMAC10.html)
CA (1) CA3177066A1 (cg-RX-API-DMAC10.html)
IL (1) IL296788A (cg-RX-API-DMAC10.html)
MX (1) MX428433B (cg-RX-API-DMAC10.html)
TW (2) TWI917367B (cg-RX-API-DMAC10.html)
WO (1) WO2021195425A1 (cg-RX-API-DMAC10.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3054674A1 (en) 2016-04-04 2017-12-10 Sinopia Biosciences, Inc. Treating extrapyramidal syndrome using trapidil
IL296788A (en) 2020-03-26 2022-11-01 Sinopia Biosciences Inc Isotopically labeled trepidil histories

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN109310700A (zh) * 2016-04-04 2019-02-05 希诺皮亚生物科学公司 使用曲匹地尔治疗锥体外系综合征
CN115916180A (zh) * 2020-03-26 2023-04-04 希诺皮亚生物科学公司 同位素标记的曲匹地尔衍生物

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Also Published As

Publication number Publication date
JP2023519289A (ja) 2023-05-10
JP7730336B2 (ja) 2025-08-27
TW202202502A (zh) 2022-01-16
AU2021244241A1 (en) 2022-11-24
CN116496279A (zh) 2023-07-28
MX2022011879A (es) 2023-01-11
US12508267B2 (en) 2025-12-30
TW202547838A (zh) 2025-12-16
TWI917367B (zh) 2026-03-11
EP4125853A1 (en) 2023-02-08
US20230102580A1 (en) 2023-03-30
JP2025183224A (ja) 2025-12-16
IL296788A (en) 2022-11-01
KR20230013023A (ko) 2023-01-26
EP4125853A4 (en) 2024-07-03
WO2021195425A1 (en) 2021-09-30
CA3177066A1 (en) 2021-09-30
TWI918457B (zh) 2026-03-11
CN115916180A (zh) 2023-04-04
MX428433B (es) 2025-11-13
CN121550230A (zh) 2026-02-24

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