MX428433B - Derivados de trapidilo marcados isotopicamente - Google Patents
Derivados de trapidilo marcados isotopicamenteInfo
- Publication number
- MX428433B MX428433B MX2022011879A MX2022011879A MX428433B MX 428433 B MX428433 B MX 428433B MX 2022011879 A MX2022011879 A MX 2022011879A MX 2022011879 A MX2022011879 A MX 2022011879A MX 428433 B MX428433 B MX 428433B
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- isotopically
- trapidyl
- parkinson
- labelled
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063000347P | 2020-03-26 | 2020-03-26 | |
| US202063063846P | 2020-08-10 | 2020-08-10 | |
| PCT/US2021/024226 WO2021195425A1 (en) | 2020-03-26 | 2021-03-25 | Isotopically-labelled trapidil derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2022011879A MX2022011879A (es) | 2023-01-11 |
| MX428433B true MX428433B (es) | 2025-11-13 |
Family
ID=77892379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022011879A MX428433B (es) | 2020-03-26 | 2021-03-25 | Derivados de trapidilo marcados isotopicamente |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12508267B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP4125853A4 (cg-RX-API-DMAC10.html) |
| JP (2) | JP7730336B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR20230013023A (cg-RX-API-DMAC10.html) |
| CN (3) | CN116496279B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2021244241A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA3177066A1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL296788A (cg-RX-API-DMAC10.html) |
| MX (1) | MX428433B (cg-RX-API-DMAC10.html) |
| TW (2) | TWI917367B (cg-RX-API-DMAC10.html) |
| WO (1) | WO2021195425A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3054674A1 (en) | 2016-04-04 | 2017-12-10 | Sinopia Biosciences, Inc. | Treating extrapyramidal syndrome using trapidil |
| IL296788A (en) | 2020-03-26 | 2022-11-01 | Sinopia Biosciences Inc | Isotopically labeled trepidil histories |
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| CA3054674A1 (en) * | 2016-04-04 | 2017-12-10 | Sinopia Biosciences, Inc. | Treating extrapyramidal syndrome using trapidil |
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| IL296788A (en) | 2020-03-26 | 2022-11-01 | Sinopia Biosciences Inc | Isotopically labeled trepidil histories |
| WO2021262786A1 (en) | 2020-06-24 | 2021-12-30 | Yale University | Pank modulators and methods using same |
-
2021
- 2021-03-25 IL IL296788A patent/IL296788A/en unknown
- 2021-03-25 TW TW110110928A patent/TWI917367B/zh active
- 2021-03-25 WO PCT/US2021/024226 patent/WO2021195425A1/en not_active Ceased
- 2021-03-25 TW TW114111322A patent/TWI918457B/zh active
- 2021-03-25 CA CA3177066A patent/CA3177066A1/en active Pending
- 2021-03-25 CN CN202310374367.9A patent/CN116496279B/zh active Active
- 2021-03-25 KR KR1020227037235A patent/KR20230013023A/ko active Pending
- 2021-03-25 CN CN202511776120.5A patent/CN121550230A/zh active Pending
- 2021-03-25 CN CN202180038452.7A patent/CN115916180A/zh active Pending
- 2021-03-25 MX MX2022011879A patent/MX428433B/es unknown
- 2021-03-25 AU AU2021244241A patent/AU2021244241A1/en active Pending
- 2021-03-25 JP JP2022558003A patent/JP7730336B2/ja active Active
- 2021-03-25 EP EP21774988.6A patent/EP4125853A4/en active Pending
-
2022
- 2022-09-23 US US17/934,680 patent/US12508267B2/en active Active
-
2025
- 2025-08-14 JP JP2025135217A patent/JP2025183224A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023519289A (ja) | 2023-05-10 |
| JP7730336B2 (ja) | 2025-08-27 |
| TW202202502A (zh) | 2022-01-16 |
| AU2021244241A1 (en) | 2022-11-24 |
| CN116496279A (zh) | 2023-07-28 |
| MX2022011879A (es) | 2023-01-11 |
| US12508267B2 (en) | 2025-12-30 |
| TW202547838A (zh) | 2025-12-16 |
| TWI917367B (zh) | 2026-03-11 |
| EP4125853A1 (en) | 2023-02-08 |
| US20230102580A1 (en) | 2023-03-30 |
| JP2025183224A (ja) | 2025-12-16 |
| IL296788A (en) | 2022-11-01 |
| KR20230013023A (ko) | 2023-01-26 |
| EP4125853A4 (en) | 2024-07-03 |
| WO2021195425A1 (en) | 2021-09-30 |
| CA3177066A1 (en) | 2021-09-30 |
| TWI918457B (zh) | 2026-03-11 |
| CN115916180A (zh) | 2023-04-04 |
| CN116496279B (zh) | 2025-12-12 |
| CN121550230A (zh) | 2026-02-24 |