CN116458475A - 表达外源末端脱氧核苷酸转移酶的非人动物 - Google Patents

表达外源末端脱氧核苷酸转移酶的非人动物 Download PDF

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Publication number
CN116458475A
CN116458475A CN202310402666.9A CN202310402666A CN116458475A CN 116458475 A CN116458475 A CN 116458475A CN 202310402666 A CN202310402666 A CN 202310402666A CN 116458475 A CN116458475 A CN 116458475A
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human
immunoglobulin
tcr
human animal
percentage
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CN202310402666.9A
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Chinese (zh)
Inventor
L·麦克唐纳
A·J·莫菲
C·郭
N·莱温科娃
N·图
J·麦克维尔特
V·沃罗宁那
F·哈里斯
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of CN116458475A publication Critical patent/CN116458475A/zh
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
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    • C12N15/09—Recombinant DNA-technology
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1264—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal nucleotidyl transferase
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    • A01K2217/00—Genetically modified animals
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    • A01K2217/00—Genetically modified animals
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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CN202310402666.9A 2016-06-03 2017-06-02 表达外源末端脱氧核苷酸转移酶的非人动物 Pending CN116458475A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662345524P 2016-06-03 2016-06-03
US62/345,524 2016-06-03
CN201780048900.5A CN109640644B (zh) 2016-06-03 2017-06-02 表达外源末端脱氧核苷酸转移酶的非人动物
PCT/US2017/035731 WO2017210586A1 (en) 2016-06-03 2017-06-02 Non-human animals expressing exogenous terminal deoxynucleotidyltransferase

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CN201780048900.5A Division CN109640644B (zh) 2016-06-03 2017-06-02 表达外源末端脱氧核苷酸转移酶的非人动物

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CN116458475A true CN116458475A (zh) 2023-07-21

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CN202310402666.9A Pending CN116458475A (zh) 2016-06-03 2017-06-02 表达外源末端脱氧核苷酸转移酶的非人动物
CN201780048900.5A Active CN109640644B (zh) 2016-06-03 2017-06-02 表达外源末端脱氧核苷酸转移酶的非人动物
CN202111170801.9A Active CN113907043B (zh) 2016-06-03 2017-06-02 表达外源末端脱氧核苷酸转移酶的非人动物

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CN202111170801.9A Active CN113907043B (zh) 2016-06-03 2017-06-02 表达外源末端脱氧核苷酸转移酶的非人动物

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US (3) US10980221B2 (https=)
EP (3) EP4567104A3 (https=)
JP (5) JP7053499B2 (https=)
KR (3) KR102483193B1 (https=)
CN (3) CN116458475A (https=)
AU (2) AU2017272337C1 (https=)
BR (1) BR112018074794A2 (https=)
CA (1) CA3026088A1 (https=)
CY (1) CY1126063T1 (https=)
DK (2) DK3462853T3 (https=)
ES (2) ES2941810T3 (https=)
FI (2) FI4218408T3 (https=)
HR (2) HRP20230497T1 (https=)
HU (2) HUE071052T2 (https=)
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PL (2) PL3462853T3 (https=)
PT (2) PT3462853T (https=)
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SI (2) SI3462853T1 (https=)
SM (2) SMT202300132T1 (https=)
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EP3699190B9 (en) 2013-02-22 2023-10-04 Regeneron Pharmaceuticals, Inc. Murine cell expressing humanized major histocompatibility complex
KR102483193B1 (ko) 2016-06-03 2023-01-04 리제너론 파마슈티칼스 인코포레이티드 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물
HUE060608T2 (hu) 2017-12-05 2023-03-28 Regeneron Pharma Genetikailag módosított immunglobulin lambda könnyûlánccal rendelkezõ egerek és azok alkalmazása
EP3772927B1 (en) * 2018-03-24 2025-01-15 Regeneron Pharmaceuticals, Inc. Genetically modified mice or rats for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof
WO2019241122A1 (en) * 2018-06-13 2019-12-19 The Children's Medical Center Corporation Methods and compositions relating to high-throughput models for antibody discovery and/or optimization
IL318469A (en) 2018-06-14 2025-03-01 Regeneron Pharma Non-human animals capable of reorganizing transgenic DH-DH, and their uses
BR112021016173A2 (pt) * 2019-02-22 2021-11-03 Regeneron Pharma Roedor geneticamente modificado, métodos de produção de um roedor geneticamente modificado e de produção de um anticorpo anti-nav1.7, célula ou tecido isolado de roedor, linhagem celular imortalizada, embrião de roedor, construto de ácido nucleico de direcionamento, e, hibridoma
MX2021014893A (es) 2019-06-05 2022-03-11 Regeneron Pharma Animales no humanos que tienen un repertorio de cadena ligera lambda limitado expresado a partir del locus kappa y usos de estos.
CN114787346A (zh) * 2019-12-12 2022-07-22 Dna斯克瑞普特公司 用于多核苷酸无模板酶学合成的嵌合末端脱氧核苷酸转移酶
CN111057754B (zh) * 2019-12-27 2021-01-12 四川省医学科学院.四川省人民医院实验动物研究所 鉴定适用于hbv研究的动物模型的方法和应用
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