CN1164262C - 含有植物物质的颗粒及其制备方法 - Google Patents
含有植物物质的颗粒及其制备方法 Download PDFInfo
- Publication number
- CN1164262C CN1164262C CNB008076685A CN00807668A CN1164262C CN 1164262 C CN1164262 C CN 1164262C CN B008076685 A CNB008076685 A CN B008076685A CN 00807668 A CN00807668 A CN 00807668A CN 1164262 C CN1164262 C CN 1164262C
- Authority
- CN
- China
- Prior art keywords
- plant extract
- granule
- plant
- coating
- herba
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/16—Tea extraction; Tea extracts; Treating tea extract; Making instant tea
- A23F3/30—Further treatment of dried tea extract; Preparations produced thereby, e.g. instant tea
- A23F3/32—Agglomerating, flaking or tabletting or granulating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fertilizers (AREA)
Abstract
Description
量(KG) | |
Neutres | 32.5-33.5 |
包衣绿茶干燥提取物20%PVP的醇溶液 | 40.5-41.514-20 |
预包衣20%PVP的醇溶液滑石粉 | 41.6 |
润滑滑石粉 | 0.1 |
质量百分比 | |
绿茶干燥提取物 | 49.9-52.3 |
Neutres | 40.0-42.2 |
PVP K30 | 4.5-6.7 |
滑石粉 | 2-2.2 |
原材料 | 质量百分比 |
Neutres | 39.9 |
爪钩草干燥提取物 | 35.4 |
PVP K30 | 2.6 |
BDLG* | 2.2 |
醇95% | 19.4 |
滑石粉 | 0.5 |
原材料 | 质量百分比 |
爪钩草流体提取物 | 18.5 |
Neutres | 67.4 |
细微晶蔗糖 | 4.1 |
纯化水 | 4.1 |
醇 | 5.2 |
滑石粉 | 0.7 |
原材料 | 质量百分比 |
Neutres | 41.9 |
银杏干燥提取物 | 30.4 |
PVP K30 | 5.5 |
醇95% | 21.9 |
滑石粉 | 0.3 |
原材料 | 质量百分比 |
银杏流体提取物 | 19.2 |
Neutres | 61.5 |
PVP K30 | 3.0 |
醇95% | 12.3 |
滑石粉 | 4.0 |
量(%) | |
缬草干燥提取物 | 50.0% |
Neutres微颗粒(粒度为700-900μm) | 35.0% |
聚乙烯吡咯烷酮(PVP) | 7.0% |
30%聚丙烯酸酯分散体(EudragitNE 30D) | 5.0% |
滑石粉 | 3.0% |
乙醇* | 足量 |
纯化水* | 足量 |
量(%) | |
西番莲干燥提取物 | 49.9% |
Neutres微颗粒(粒度为700-900μm) | 39.9% |
聚乙烯吡咯烷酮(PVP) | 6.7% |
异丁烯酸共聚物(EudragitE 100) | 1.9% |
滑石粉 | 1.6% |
乙醇* | 足量 |
量(%) | |
掌叶葡萄干燥提取物 | 50.7% |
Neutres微颗粒(粒度为550-750μm) | 40.6% |
聚乙烯吡咯烷酮(PVP) | 5.6% |
Pharmacoat | 1.9% |
滑石粉 | 1.2% |
乙醇* | 足量 |
纯化水* | 足量 |
量(%) | |
爪钩草干燥提取物 | 49.0% |
Neutres微颗粒(粒度为550-750μm) | 20.3% |
聚乙烯吡咯烷酮(PVP) | 10.2% |
异丁烯酸共聚物:EudragitL100 | 0.3% |
异丁烯酸共聚物:EudragitL30D | 17.1% |
柠檬酸三乙酯 | 1.7% |
滑石粉 | 1.4% |
乙醇* | 足量 |
纯化水* | 足量 |
规格 | BYHAR005 | BYHAR006 | BYHAR007 | |
钩果策苷含量 | [1.90-2.10%] | 2.01% | 1.98% | 1.99% |
胃保护测试(遵照USP/NF) | 在HCl中2小时≤10%在pH6.8 45分钟≥80% | 4.8%82.1% | 6.4%85.1% | 5.2%81.8% |
示踪物含量 | 批次BYVIG 002 | 批次BYVIG 003 | 批次BYVIG 0040 |
理论含量(%) | 5.44% | 5.54% | 5.52% |
实测含量(%) | 5.44% | 5.53% | 5.52% |
示踪物含量 | 批次TGIN 001 | 批次TGIN 002 | 批次TGIN 003 |
理论含量(%) | 5.0% | 5.0% | 5.0% |
实测含量(%) | 4.9% | 4.9% | 4.9% |
质量均匀性 | 标准 | 批次99.1.01 | 批次99.1.04 | 批次99.1.05 |
平均质量 | 390-410mg | 393mg | 405mg | 401mg |
±7.5%偏差 | ≤2粒明胶胶囊 | 0粒明胶胶囊 | 1粒明胶胶囊 | 0粒明胶胶囊 |
±15%偏差 | 0粒明胶胶囊 | 0粒明胶胶囊 | 0粒明胶胶囊 | 0粒明胶胶囊 |
示踪物含量 | TGIN001 | TGIN002 | TGIN003 | ||||||
T0 | T+6月 | T0 | T+6月 | T0 | T+6月 | ||||
加速老化 | 实际条件 | 加速老化 | 实际条件 | 加速老化 | 实际条件 | ||||
理论含量 | 5.0% | 5.0% | 5.0% | 5.0% | 5.0% | 5.0% | 5.0% | 5.0% | 5.0% |
实测含量 | 4.9% | 4.9% | 4.9% | 4.9% | 4.9% | 5.0% | 4.9% | 4.9% | 5.0% |
Claims (18)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31248599A | 1999-05-17 | 1999-05-17 | |
US09/312,485 | 1999-05-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1351489A CN1351489A (zh) | 2002-05-29 |
CN1164262C true CN1164262C (zh) | 2004-09-01 |
Family
ID=23211689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008076685A Expired - Fee Related CN1164262C (zh) | 1999-05-17 | 2000-05-17 | 含有植物物质的颗粒及其制备方法 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1178778B1 (zh) |
JP (1) | JP2002544220A (zh) |
CN (1) | CN1164262C (zh) |
AT (1) | ATE318585T1 (zh) |
AU (1) | AU4764200A (zh) |
BR (1) | BR0010649A (zh) |
CA (1) | CA2374356C (zh) |
DE (1) | DE60026295T2 (zh) |
ES (1) | ES2259604T3 (zh) |
HK (1) | HK1045936A1 (zh) |
MX (1) | MXPA01011800A (zh) |
PT (1) | PT1178778E (zh) |
TW (1) | TWI229607B (zh) |
WO (1) | WO2000069414A2 (zh) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10012569A1 (de) * | 2000-03-15 | 2001-09-20 | Finzelberg Gmbh & Co Kg | Hartgelatinekapseln enthaltend retardierte Pflanzenextrakte und Verfahren zur Herstellung derselben |
JP3980952B2 (ja) * | 2002-04-12 | 2007-09-26 | 森下仁丹株式会社 | 植物抽出エキスを含有する腸溶性の脂肪吸収抑制剤およびそれを含有する食品 |
KR101148734B1 (ko) * | 2003-10-10 | 2012-07-05 | 에띠빠흠 | 징코 빌로바 추출물을 포함하는 서방형 미세과립 및 이것을 제조하는 방법 |
US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
FR2880541B1 (fr) * | 2005-01-10 | 2008-02-22 | Amalric Veret | Une nouvelle formule de plantes sous forme de micro-granules de xilitol pour renforcer les effets des plantes et leurs proprietes par une meilleure assimilation |
CN101091725A (zh) | 2006-06-23 | 2007-12-26 | 天津天士力制药股份有限公司 | 一种中药颗粒及其制备方法 |
EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
FR2938430B1 (fr) * | 2008-11-14 | 2011-05-20 | Debregeas Et Associes Pharma | Granules a base de plantes |
FR2938431B1 (fr) * | 2008-11-14 | 2013-12-20 | Debregeas Et Associes Pharma | Nouvelle composition a base d'acide gamma-hydroxybutyrique |
FR2938432B1 (fr) * | 2008-11-14 | 2011-05-20 | Debregeas Et Associes Pharma | Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus |
HUE060093T2 (hu) | 2012-03-15 | 2023-01-28 | Boehringer Ingelheim Vetmedica Gmbh | Gyógyszerészeti tablettakészítmény az állatgyógyászati ágazat számára, eljárás annak elõállítására és annak alkalmazása |
PL3021832T3 (pl) | 2013-07-19 | 2021-08-23 | Boehringer Ingelheim Vetmedica Gmbh | Konserwowana ciekła wodna kompozycja farmaceutyczna zawierająca eteryfikowane pochodne cyklodekstryny |
DK2925305T3 (en) | 2013-12-04 | 2016-10-10 | Boehringer Ingelheim Vetmedica Gmbh | Improved pharmaceutical compositions of pimobendan. |
MY190733A (en) * | 2015-11-30 | 2022-05-12 | Nestle Sa | Amorphous porous particles for reducing sugar in food |
US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
CN107372951B (zh) * | 2017-07-18 | 2021-01-01 | 刘元友 | 一种含有荨麻的抹茶粉及其制备方法 |
JP6994551B2 (ja) * | 2019-11-05 | 2022-01-14 | 花王株式会社 | 顆粒組成物 |
KR102458445B1 (ko) * | 2020-01-29 | 2022-10-24 | 박기원 | 반려동물용 다기능 미세 영양캡슐 제조방법 및 그 방법에 의해 제조된 반려동물용 미세 영양캡슐 |
FR3127118A1 (fr) * | 2021-04-06 | 2023-03-24 | Amalric VERET | Formulation de compléments alimentaires sous forme de microgranules gastro protégées et à libération contrôlée. |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1443063A (fr) * | 1963-08-27 | 1966-06-24 | Key Pharma | Préparation contenant de la théophylline |
AT336190B (de) * | 1974-07-23 | 1977-04-25 | Hurka Wilhelm | Verfahren zur herstellung von mikropellets zur behandlung von erkrankungen des mund- und rachenraumes |
FR2613223B1 (fr) * | 1987-04-03 | 1991-09-13 | Biogalenique Laboratoires | Forme galenique se presentant sous la forme de grains hydrosolubles, en particulier a base d'un extrait sec de ginkgo biloba, et son procede de preparation |
IL110035A0 (en) * | 1994-06-16 | 1994-10-07 | Tapuach Natural Technologies 1 | Homeopathic formulations |
JP4195728B2 (ja) * | 1996-10-16 | 2008-12-10 | ナポ ファーマシューティカルズ,インコーポレーテッド | プロアントシアニジンポリマー止瀉組成物の腸溶製剤 |
FR2759293B1 (fr) * | 1997-02-11 | 1999-04-30 | Ethypharm Lab Prod Ethiques | Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie |
FR2790668B1 (fr) * | 1999-03-12 | 2002-07-26 | D B F | Granules contenant une substance vegetale et leur procede de preparation |
-
2000
- 2000-05-17 MX MXPA01011800A patent/MXPA01011800A/es active IP Right Grant
- 2000-05-17 AT AT00929620T patent/ATE318585T1/de active
- 2000-05-17 ES ES00929620T patent/ES2259604T3/es not_active Expired - Lifetime
- 2000-05-17 WO PCT/FR2000/001316 patent/WO2000069414A2/fr active IP Right Grant
- 2000-05-17 DE DE60026295T patent/DE60026295T2/de not_active Expired - Lifetime
- 2000-05-17 EP EP00929620A patent/EP1178778B1/fr not_active Expired - Lifetime
- 2000-05-17 CA CA2374356A patent/CA2374356C/fr not_active Expired - Fee Related
- 2000-05-17 PT PT00929620T patent/PT1178778E/pt unknown
- 2000-05-17 JP JP2000617873A patent/JP2002544220A/ja active Pending
- 2000-05-17 BR BR0010649-6A patent/BR0010649A/pt not_active Application Discontinuation
- 2000-05-17 CN CNB008076685A patent/CN1164262C/zh not_active Expired - Fee Related
- 2000-05-17 AU AU47642/00A patent/AU4764200A/en not_active Abandoned
- 2000-06-01 TW TW089110921A patent/TWI229607B/zh not_active IP Right Cessation
-
2002
- 2002-08-13 HK HK02105911.3A patent/HK1045936A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
HK1045936A1 (zh) | 2002-12-20 |
MXPA01011800A (es) | 2003-08-19 |
EP1178778B1 (fr) | 2006-03-01 |
JP2002544220A (ja) | 2002-12-24 |
CA2374356A1 (fr) | 2000-11-23 |
WO2000069414A3 (fr) | 2001-05-31 |
EP1178778A2 (fr) | 2002-02-13 |
CN1351489A (zh) | 2002-05-29 |
ATE318585T1 (de) | 2006-03-15 |
DE60026295T2 (de) | 2006-10-12 |
BR0010649A (pt) | 2002-02-19 |
WO2000069414A2 (fr) | 2000-11-23 |
CA2374356C (fr) | 2012-01-03 |
PT1178778E (pt) | 2006-06-30 |
ES2259604T3 (es) | 2006-10-16 |
TWI229607B (en) | 2005-03-21 |
DE60026295D1 (de) | 2006-04-27 |
AU4764200A (en) | 2000-12-05 |
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Effective date of registration: 20081114 Address after: The French Saint Cloud Patentee after: Effalm S.A. Address before: The French Saint Cloud Patentee before: D.B.F. |
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