CN115969760A - Hyaluronic acid essence and preparation method thereof - Google Patents
Hyaluronic acid essence and preparation method thereof Download PDFInfo
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Abstract
The invention discloses hyaluronic acid essence and a preparation method thereof, belonging to the technical field of skin care products, wherein the essence comprises the following components: sodium hyaluronate, alpha-arbutin modified sodium hyaluronate, aloe extract, nicotinamide, glycerol and water; the alpha-arbutin modified sodium hyaluronate is prepared by the following method: respectively dissolving alpha-arbutin and micromolecular sodium hyaluronate in water to prepare a mixture solution, dropwise adding a catalyst solution into the mixture solution, stirring for reaction, dialyzing the reactant, and drying to obtain the product. The essence is added with the alpha-arbutin modified sodium hyaluronate which is cooperated with the nicotinamide, and the problems of poor whitening effect and long effective time of the existing whitening products are effectively solved under the combined action of synthesis and transfer.
Description
Technical Field
The invention relates to the technical field of skin care products, and particularly relates to hyaluronic acid essence and a preparation method thereof.
Background
Hyaluronic acid, also known as hyaluronic acid, is an acidic mucopolysaccharide. The moisturizing factor is an important basic substance for skin tenderness, is a component of a human body, has a special moisturizing effect, is 100 times higher in weight after water absorption, is a substance which is found to have the best moisturizing effect in nature at present, and is called as an ideal natural moisturizing factor. It can improve skin nutrition metabolism, make skin tender and smooth, remove wrinkle, increase elasticity, and prevent aging, and is good transdermal absorption promoter while keeping moisture. The nutrient can be used together with other nutrient components to achieve the more ideal effect of promoting nutrient absorption.
The components such as alpha-arbutin, nicotinamide and the like are commonly used whitening components in the current cosmetics, and the alpha-arbutin can inhibit the activity of tyrosinase in vivo and prevent the generation of melanin, so that the deposition of skin melanin is reduced; the nicotinamide accelerates the epidermal metabolism by stopping the converted pigment from moving to the epidermis, and enables the body cells with melanin to be metabolized, thereby achieving the purpose of whitening; however, the existing whitening products containing nicotinamide or arbutin have the problems of slow effect and unobvious whitening effect.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides hyaluronic acid essence and a preparation method thereof, wherein alpha-arbutin modified sodium hyaluronate is added into the essence to cooperate with nicotinamide, and the alpha-arbutin modified sodium hyaluronate and the nicotinamide are combined to act from two aspects of synthesis and transfer, so that the problems of poor whitening effect and long effective time of the existing whitening products are effectively solved.
In order to achieve the purpose, the technical scheme adopted by the invention for solving the technical problems is as follows:
hyaluronic acid essence comprises the following components: sodium hyaluronate, alpha-arbutin modified sodium hyaluronate, aloe extract, nicotinamide, glycerol and water;
the alpha-arbutin modified sodium hyaluronate is prepared by the following method: respectively dissolving alpha-arbutin and micromolecular sodium hyaluronate in water to prepare a mixture solution, dropwise adding a catalyst solution into the mixture solution, stirring for reaction, dialyzing the reactant, and drying to obtain the product.
Further, the paint comprises the following components in parts by weight: 0.1-0.3 part of sodium hyaluronate, 0.1-0.3 part of alpha-arbutin modified sodium hyaluronate, 0.1-0.3 part of aloe extract, 0.1-0.3 part of nicotinamide, 8-12 parts of glycerol and 180-200 parts of water.
Further, the catalyst is N-N' -diisopropylcarbodiimide or 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride.
Further, the mass ratio of the alpha-arbutin to the micromolecular sodium hyaluronate is 0.5-0.8.
Further, the molecular weight of the small molecule sodium hyaluronate is 0.5-1 ten thousand daltons.
Further, the reaction temperature was 20-40 ℃ with stirring.
Further, the molecular weight of sodium hyaluronate is 2-40 ten thousand daltons.
The preparation method of the hyaluronic acid essence comprises the following steps: mixing glycerol and water at 40-70 deg.C, adding sodium hyaluronate, stirring to dissolve, and swelling; cooling the mixture to 20-35 deg.C, adding alpha-arbutin modified sodium hyaluronate and nicotinamide, stirring for dissolving, adding aloe extract, stirring for dissolving, and filtering to obtain the final product.
The beneficial effects produced by the invention are as follows:
1. the essence disclosed by the invention is added with the alpha-arbutin modified sodium hyaluronate, and the alpha-arbutin has a strong permeation effect, can rapidly permeate into the deep layer of skin, and can inhibit the activity of tyrosinase in vivo and prevent melanin from being generated, so that the purpose of whitening is achieved; the small molecular hyaluronic acid also has strong osmosis, can permeate to the deep layer of the skin and act on intercellular spaces, contains a plurality of strong polar hydroxyls, and absorbs a large amount of water by utilizing the hydrophilic characteristic of the hyaluronic acid to fulfill the aim of moisturizing the skin; according to the application, the hydroxyl on the alpha-arbutin and the carboxyl on hyaluronic acid are subjected to esterification reaction, so that the alpha-arbutin and the hyaluronic acid are grafted, and researches show that the grafted product has the following advantages that firstly, the whitening effect of the alpha-arbutin is enhanced, presumably because sodium hyaluronate in alpha-arbutin modified sodium hyaluronate absorbs a large amount of water, so that the alpha-arbutin is in a high-moisture environment, so that the activity of the alpha-arbutin is enhanced, after the alpha-arbutin is combined with tyrosinase, the combined product is diluted and metabolized in the high-moisture environment, the consumption of the tyrosinase is increased due to the high-moisture content, the content of the tyrosinase participating in melanin formation is reduced, namely, the synthesis amount of the melanin is reduced, and the whitening effect is improved; secondly, the deep water replenishing effect is enhanced, presumably because the molecular weight of the alpha-arbutin is small, the alpha-arbutin can quickly permeate into the deep layer of the skin, and the hyaluronic acid is quickly pulled to move to the deep layer of the skin under the pulling action of the alpha-arbutin, so that the permeation effect of the hyaluronic acid is increased, and the deep water replenishing effect of the hyaluronic acid is improved, namely the interaction between the alpha-arbutin and sodium hyaluronate in the alpha-arbutin modified sodium hyaluronate improves the action effect of the alpha-arbutin and the sodium hyaluronate.
2. The essence disclosed by the invention is also added with a nicotinamide component, and the nicotinamide realizes the whitening effect by inhibiting the conduction of formed melanin to epidermis; the sodium hyaluronate absorbs a large amount of water, so that a high-humidity tissue environment is provided, the metabolism of melanin is accelerated, and the quantity of the melanin conducted outwards is reduced; according to the application, the nicotinamide and the alpha-arbutin modified sodium hyaluronate component are used simultaneously, the generation of melanin is reduced from the source through the alpha-arbutin component, the outward conduction of formed trace melanin is inhibited through the nicotinamide component, meanwhile, a high-humidity cell environment is formed by utilizing the water absorption property of the sodium hyaluronate, the metabolic over-speed of a product is accelerated, the effects are exerted in the three aspects of synthesis, conduction and metabolism, the whitening effect is shortened, and the purpose of improving the whitening effect is achieved.
3. According to the application, the sodium hyaluronate with large molecular weight is used, acts on the skin superficial layer, and the moisture preservation purpose is realized on the skin surface layer by utilizing the characteristic of strong water absorption of the sodium hyaluronate.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.
Thus, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without making any creative effort, shall fall within the protection scope of the present invention.
It is noted that relational terms such as "first" and "second," and the like, may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrases "comprising a component of' ...does not exclude the presence of additional identical elements in the process, method, article, or apparatus that comprises the element.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
Hyaluronic acid essence comprises the following components in parts by weight: 0.2 part of sodium hyaluronate with the molecular weight of 5 ten thousand daltons, 0.2 part of alpha-arbutin modified sodium hyaluronate, 0.2 part of aloe extract, 0.2 part of nicotinamide, 10 parts of glycerol and 189 parts of water;
the alpha-arbutin modified sodium hyaluronate is prepared by the following method: respectively dissolving alpha-arbutin and micromolecular sodium hyaluronate with the molecular weight of 0.5 ten thousand daltons into water, continuously stirring to prepare a mixture solution, dripping an N-N' -diisopropylcarbodiimide catalyst solution with the mass concentration of 1% into the mixture solution under the stirring condition, stirring and reacting for 6 hours at the temperature of 20 ℃, dialyzing reactants, and freeze-drying to prepare the product, wherein the mass ratio of the alpha-arbutin to the micromolecular sodium hyaluronate is 0.5.
The preparation method of the hyaluronic acid essence comprises the following steps: adding water into a liquid preparation tank, heating to 40 ℃, adding glycerol into the liquid preparation tank, setting the rotating speed of a stirrer to 1400 revolutions per minute, stirring and mixing, adding sodium hyaluronate, stirring until the sodium hyaluronate is completely dissolved, and continuing stirring and swelling for 1h; cooling the mixture to 20 deg.C under stirring, adding alpha-arbutin modified sodium hyaluronate and nicotinamide, stirring for dissolving, adding Aloe extract, stirring for dissolving, adjusting pH of the mixed solution to 6.8, and filtering with 0.45 micrometer and 0.2 micrometer filter membrane.
Example 2
Hyaluronic acid essence comprises the following components in parts by weight: 0.3 part of sodium hyaluronate with the molecular weight of 10 ten thousand daltons, 0.3 part of alpha-arbutin modified sodium hyaluronate, 0.3 part of aloe extract, 0.3 part of nicotinamide, 12 parts of glycerol and 200 parts of water;
the alpha-arbutin modified sodium hyaluronate is prepared by the following method: respectively dissolving alpha-arbutin and micromolecular sodium hyaluronate with the molecular weight of 1 ten thousand daltons into water, continuously stirring to prepare a mixture solution, dripping an N-N' -diisopropylcarbodiimide catalyst solution with the mass concentration of 1% into the mixture solution under the stirring condition, stirring and reacting for 8 hours at the temperature of 40 ℃, dialyzing reactants, and freeze-drying to prepare the product, wherein the mass ratio of the alpha-arbutin to the micromolecular sodium hyaluronate is 0.8.
The preparation method of the hyaluronic acid essence comprises the following steps: adding water into a liquid preparation tank, heating to 60 ℃, adding glycerol into the liquid preparation tank, setting the rotating speed of a stirrer to 1400 revolutions per minute, stirring and mixing, adding sodium hyaluronate, stirring until the sodium hyaluronate is completely dissolved, and continuing stirring and swelling for 1h; cooling the mixture to 30 ℃ while stirring, adding alpha-arbutin modified sodium hyaluronate and nicotinamide, stirring for dissolving, adding aloe extract, stirring for dissolving, adjusting the pH value of the mixed solution to 7.0, and filtering through 0.45 micrometer and 0.2 micrometer filter membranes in sequence to obtain the aloe vera extract.
Example 3
Hyaluronic acid essence comprises the following components in parts by weight: 0.15 part of sodium hyaluronate with the molecular weight of 4 ten thousand daltons, 0.15 part of alpha-arbutin modified sodium hyaluronate, 0.15 part of aloe extract, 0.15 part of nicotinamide, 9 parts of glycerol and 190 parts of water;
the alpha-arbutin modified sodium hyaluronate is prepared by the following method: respectively dissolving alpha-arbutin and micromolecular sodium hyaluronate with the molecular weight of 0.7 ten thousand daltons into water, continuously stirring to prepare a mixture solution, dropwise adding an N-N' -diisopropylcarbodiimide catalyst solution with the mass concentration of 1% into the mixture solution under the stirring condition, stirring and reacting for 7 hours at the temperature of 25 ℃, dialyzing reactants, and freeze-drying to prepare the product, wherein the mass ratio of the alpha-arbutin to the micromolecular sodium hyaluronate is 0.7.
The preparation method of the hyaluronic acid essence comprises the following steps: adding water into a liquid preparation tank, heating to 60 ℃, adding glycerol into the liquid preparation tank, setting the rotating speed of a stirrer to 1400 revolutions per minute, stirring and mixing, adding sodium hyaluronate, stirring until the sodium hyaluronate is completely dissolved, and continuing stirring and swelling for 1h; cooling the mixture to 30 ℃ while stirring, adding alpha-arbutin modified sodium hyaluronate and nicotinamide, stirring for dissolving, adding aloe extract, stirring for dissolving, adjusting the pH value of the mixed solution to 6.0, and filtering with 0.45 micrometer and 0.2 micrometer filter membranes in sequence to obtain the aloe vera extract.
Example 4
Hyaluronic acid essence comprises the following components in parts by weight: 0.2 part of sodium hyaluronate with the molecular weight of 9 ten thousand daltons, 0.3 part of alpha-arbutin modified sodium hyaluronate, 0.2 part of aloe extract, 0.15 part of nicotinamide, 10 parts of glycerol and 190 parts of water;
the alpha-arbutin modified sodium hyaluronate is prepared by the following method: respectively dissolving alpha-arbutin and micromolecular sodium hyaluronate with the molecular weight of 0.6 ten thousand daltons into water, continuously stirring to prepare a mixture solution, dropwise adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride catalyst solution with the mass concentration of 1% into the mixture solution under the stirring condition, stirring and reacting for 7 hours at the temperature of 25 ℃, dialyzing reactants, and freeze-drying to prepare the product, wherein the mass ratio of the alpha-arbutin to the micromolecular sodium hyaluronate is 0.6.
The preparation method of the hyaluronic acid essence comprises the following steps: adding water into a liquid preparation tank, heating to 60 ℃, adding glycerol into the liquid preparation tank, setting the rotating speed of a stirrer to 1400 revolutions per minute, stirring and mixing, adding sodium hyaluronate, stirring until the sodium hyaluronate is completely dissolved, and continuing stirring and swelling for 1h; cooling the mixture to 30 ℃ while stirring, adding alpha-arbutin modified sodium hyaluronate and nicotinamide, stirring for dissolving, adding aloe extract, stirring for dissolving, adjusting the pH value of the mixed solution to 6.0, and filtering with 0.45 micrometer and 0.2 micrometer filter membranes in sequence to obtain the aloe vera extract.
Comparative example 1
Hyaluronic acid essence comprises the following components in parts by weight: 0.2 part of sodium hyaluronate with molecular weight of 5 kilodalton, 0.5 part of alpha-arbutin, 0.5 part of micromolecular sodium hyaluronate with molecular weight of 0.5 kilodalton, 0.2 part of aloe extract, 0.2 part of nicotinamide, 10 parts of glycerol and 189 parts of water.
The preparation method of the essence is the same as that of example 1.
Comparative example 2
Hyaluronic acid essence comprises the following components in parts by weight: 0.2 part of sodium hyaluronate with the molecular weight of 5 ten thousand daltons, 0.2 part of alpha-arbutin modified sodium hyaluronate, 0.2 part of aloe extract, 10 parts of glycerol and 189 parts of water;
the alpha-arbutin modified sodium hyaluronate is prepared by the following method: respectively dissolving alpha-arbutin and micromolecular sodium hyaluronate with the molecular weight of 0.5 ten thousand daltons into water, continuously stirring to prepare a mixture solution, dripping an N-N' -diisopropylcarbodiimide catalyst solution with the mass concentration of 1% into the mixture solution under the stirring condition, stirring and reacting for 6 hours at the temperature of 20 ℃, dialyzing reactants, and freeze-drying to prepare the product, wherein the mass ratio of the alpha-arbutin to the micromolecular sodium hyaluronate is 0.5.
The preparation method of the essence is the same as that of example 1.
Test examples
Whitening test experiment
1. The tester: 60 healthy Asian women aged 30-35 years randomly divided into 6 groups of 10 persons each;
2. testing parts: a cheek;
3. and (3) testing a product: the essences of examples 1 to 4 and comparative examples 1 to 2;
4. the test method comprises the following steps: before the experiment begins, testing the cheek ITA degrees and brightness of each group of testees, and calculating the average ITA degrees and the average brightness of each group of testees as statistical data; after cleaning face in the morning and evening, 6 groups of subjects apply the essence in the examples 1-4 and the comparative examples 1-2 to the cheek respectively, each application amount is 5ml, no skin care product is applied, each subject is irradiated by sunlight for less than 30min every day and is continuously used for 4 weeks, ITA degrees and brightness of each group of subjects are tested at 2 weeks, 3 weeks and 4 weeks respectively, average ITA degrees and average brightness of each group of subjects are calculated, average ITA degrees and average brightness changes before and after the test are calculated, and specific test results are shown in tables 2-4.
Luminance change value (Δ L) = average luminance before test L — average luminance after test L
ITA ° variation value (Δ ITA °) = mean after-test ITA ° -mean before-test ITA °
Table 1: ITA DEG is divided into six types
Table 2: ITA ° and change in brightness after 2 weeks of use
Table 3: ITA ° and luminance change after 3 weeks of use
Table 4: ITA and change in brightness after 4 weeks of use
As can be seen from the data in tables 2 to 4, the average brightness change (DeltaL) and the average ITA DEG change (DeltaITA DEG) of the skin of 4 groups of subjects in groups 1 to 4 are larger than those of the subjects in groups 5 to 6, which proves that the essence in examples 1 to 4 has better whitening effect and better effect on brightening the skin color of the subjects.
As can be seen from table 2, after the group 1-4 subjects use the essence of examples 1-4 for 2 weeks, the skin of the subjects has increased brightness and increased ITA °, while the skin of the subjects using the essence of comparative examples 1-2 in the group 5-6 subjects has not significantly changed, which proves that the time required for the effect of the whitening and skin brightening essence of examples 1-4 is shorter, i.e., the whitening and skin brightening essence has the advantage of quick effect; as can be further seen from the data in tables 3 and 4, the essence solutions of examples 1 to 4 are superior in whitening effect to the essence solutions of comparative examples 1 to 2.
The essence in the comparative example 1 is compared with the essence in the embodiment 1, alpha-arbutin and micromolecular sodium hyaluronate are directly added in the comparative example 1 and are not modified, and according to the result, the whitening effect and the whitening effect time of the essence directly added with the alpha-arbutin and the micromolecular sodium hyaluronate are not as good as those of the essence in the embodiment 1.
Comparing the essence in the comparative example 2 with the essence in the example 1, the use of nicotinamide in the comparative example 2 is eliminated, and according to the result, the whitening effect of the essence in the comparative example 2 is poor, and presumably because the nicotinamide is eliminated, a small amount of generated melanin is transferred to the outer layer of the skin, the color of the skin is increased, and the whitening effect of the essence is poor.
Claims (8)
1. The hyaluronic acid essence is characterized by comprising the following components: sodium hyaluronate, alpha-arbutin modified sodium hyaluronate, aloe extract, nicotinamide, glycerol and water;
the alpha-arbutin modified sodium hyaluronate is prepared by the following method: respectively dissolving alpha-arbutin and micromolecular sodium hyaluronate in water to prepare a mixture solution, dropwise adding a catalyst solution into the mixture solution, stirring for reaction, dialyzing the reactant, and drying to obtain the product.
2. The hyaluronic acid essence of claim 1, which comprises the following components in parts by weight: 0.1-0.3 part of sodium hyaluronate, 0.1-0.3 part of alpha-arbutin modified sodium hyaluronate, 0.1-0.3 part of aloe extract, 0.1-0.3 part of nicotinamide, 8-12 parts of glycerol and 180-200 parts of water.
3. The hyaluronic acid serum of claim 1, wherein the catalyst is N-N' -diisopropylcarbodiimide or 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride.
4. The hyaluronic acid essence of claim 1, wherein the mass ratio of the alpha-arbutin to the small-molecule sodium hyaluronate is 0.5-0.8.
5. The hyaluronic acid essence of claim 1, wherein the small-molecule sodium hyaluronate has a molecular weight of 0.5-1 ten thousand daltons.
6. The hyaluronic acid essence of claim 1, wherein the stirring reaction temperature is 20-40 ℃.
7. The hyaluronic acid essence of claim 1, wherein the sodium hyaluronate has a molecular weight of 2 to 40 ten thousand daltons.
8. The method for preparing hyaluronic acid essence of any of claims 1-7, comprising the following steps: mixing glycerol and water at 40-70 deg.C, adding sodium hyaluronate, stirring to dissolve, and swelling; cooling the mixture to 20-35 deg.C, adding alpha-arbutin modified sodium hyaluronate and nicotinamide, stirring for dissolving, adding aloe extract, stirring for dissolving, and filtering to obtain the final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116370324A (en) * | 2023-06-06 | 2023-07-04 | 成都普什制药有限公司 | Anti-oxidation essence containing hyaluronic acid and preparation method thereof |
| CN116509755A (en) * | 2023-07-04 | 2023-08-01 | 成都普什制药有限公司 | Inferior throwing separation type mask and mask essence containing same |
| CN117618321A (en) * | 2024-01-24 | 2024-03-01 | 成都普什制药有限公司 | Moisturizing and repairing essence and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106279729A (en) * | 2016-08-26 | 2017-01-04 | 北京大清生物技术有限公司 | A kind of cross-linking hyaluronic acid gel and preparation method and application |
| CN108264581A (en) * | 2017-02-20 | 2018-07-10 | 上海昊海生物科技股份有限公司 | A kind of self-crosslinking Sodium Hyaluronate and preparation method thereof |
| CN110538092A (en) * | 2019-09-20 | 2019-12-06 | 南通大学 | Whitening and moisturizing alginate mask and preparation method thereof |
| CN111743818A (en) * | 2020-08-24 | 2020-10-09 | 彭震炉 | Whitening essence |
| CN111956585A (en) * | 2020-08-10 | 2020-11-20 | 湖南本美生物科技有限公司 | Carnosine freckle removing liquid and preparation method thereof |
| CN112716871A (en) * | 2021-01-21 | 2021-04-30 | 中恩（天津）医药科技有限公司 | A skin-permeable absorption facial mask with effects of shrinking pores, moistening skin, and whitening skin |
-
2023
- 2023-03-20 CN CN202310269260.8A patent/CN115969760B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106279729A (en) * | 2016-08-26 | 2017-01-04 | 北京大清生物技术有限公司 | A kind of cross-linking hyaluronic acid gel and preparation method and application |
| CN108264581A (en) * | 2017-02-20 | 2018-07-10 | 上海昊海生物科技股份有限公司 | A kind of self-crosslinking Sodium Hyaluronate and preparation method thereof |
| CN110538092A (en) * | 2019-09-20 | 2019-12-06 | 南通大学 | Whitening and moisturizing alginate mask and preparation method thereof |
| CN111956585A (en) * | 2020-08-10 | 2020-11-20 | 湖南本美生物科技有限公司 | Carnosine freckle removing liquid and preparation method thereof |
| CN111743818A (en) * | 2020-08-24 | 2020-10-09 | 彭震炉 | Whitening essence |
| CN112716871A (en) * | 2021-01-21 | 2021-04-30 | 中恩（天津）医药科技有限公司 | A skin-permeable absorption facial mask with effects of shrinking pores, moistening skin, and whitening skin |
Non-Patent Citations (1)
| Title |
|---|
| 高瑞英等: "超声乳化法构建化妆品用用熊果苷/透明质酸 －-己二酸二酰肼交联载药微球", 时珍国医国药, vol. 21, no. 8 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116370324A (en) * | 2023-06-06 | 2023-07-04 | 成都普什制药有限公司 | Anti-oxidation essence containing hyaluronic acid and preparation method thereof |
| CN116370324B (en) * | 2023-06-06 | 2023-08-15 | 成都普什制药有限公司 | Anti-oxidation essence containing hyaluronic acid and preparation method thereof |
| CN116509755A (en) * | 2023-07-04 | 2023-08-01 | 成都普什制药有限公司 | Inferior throwing separation type mask and mask essence containing same |
| CN116509755B (en) * | 2023-07-04 | 2023-09-05 | 成都普什制药有限公司 | Inferior throwing separation type mask and mask essence containing same |
| CN117618321A (en) * | 2024-01-24 | 2024-03-01 | 成都普什制药有限公司 | Moisturizing and repairing essence and preparation method thereof |
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