CN1159316C - 异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物 - Google Patents

异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物 Download PDF

Info

Publication number
CN1159316C
CN1159316C CNB021070547A CN02107054A CN1159316C CN 1159316 C CN1159316 C CN 1159316C CN B021070547 A CNB021070547 A CN B021070547A CN 02107054 A CN02107054 A CN 02107054A CN 1159316 C CN1159316 C CN 1159316C
Authority
CN
China
Prior art keywords
formula
compound
branched
straight
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB021070547A
Other languages
English (en)
Chinese (zh)
Other versions
CN1375494A (zh
Inventor
M
M·威尔兹比克
M－F·博萨德
A·罗斯奥
J-A·布廷
P·德拉格兰杰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of CN1375494A publication Critical patent/CN1375494A/zh
Application granted granted Critical
Publication of CN1159316C publication Critical patent/CN1159316C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB021070547A 2001-03-12 2002-03-12 异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物 Expired - Fee Related CN1159316C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0103293 2001-03-12
FR0103293A FR2821843B1 (fr) 2001-03-12 2001-03-12 Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
CN1375494A CN1375494A (zh) 2002-10-23
CN1159316C true CN1159316C (zh) 2004-07-28

Family

ID=8860976

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB021070547A Expired - Fee Related CN1159316C (zh) 2001-03-12 2002-03-12 异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物

Country Status (24)

Country Link
US (1) US6465660B1 (https=)
EP (1) EP1241169B1 (https=)
JP (1) JP3842151B2 (https=)
KR (1) KR100450313B1 (https=)
CN (1) CN1159316C (https=)
AR (1) AR034583A1 (https=)
AT (1) ATE248171T1 (https=)
AU (1) AU779702B2 (https=)
BR (1) BR0200721A (https=)
CA (1) CA2376876C (https=)
DE (1) DE60200023T2 (https=)
DK (1) DK1241169T3 (https=)
EA (1) EA004035B1 (https=)
ES (1) ES2206438T3 (https=)
FR (1) FR2821843B1 (https=)
HK (1) HK1049000B (https=)
HU (1) HUP0200913A3 (https=)
MX (1) MXPA02002601A (https=)
NO (1) NO20021198L (https=)
NZ (1) NZ517742A (https=)
PL (1) PL352750A1 (https=)
PT (1) PT1241169E (https=)
SI (1) SI1241169T1 (https=)
ZA (1) ZA200202030B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2826009B1 (fr) * 2001-06-13 2003-08-15 Servier Lab Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2003249584B9 (en) * 2002-06-21 2008-05-15 Suven Life Sciences Limited Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
AU2003249583B2 (en) * 2002-06-21 2007-06-07 Suven Life Sciences Limited Novel tetracyclic arylcarbonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
PT1567492E (pt) * 2002-11-28 2013-07-22 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxi-indóis
DK1581538T3 (da) * 2002-12-18 2007-06-25 Suven Life Sciences Ltd Tetracykliske 3-substituerede indoler med serotoninreceptoraffinitet
RU2387655C2 (ru) * 2004-08-09 2010-04-27 Бристол-Маерс Сквибб Компани Ингибиторы репликации вируса гепатита с
ES2580702B1 (es) 2015-02-25 2017-06-08 Palobiofarma, S.L. Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina
AU2023333524A1 (en) 2022-09-02 2025-04-03 Dexcom, Inc. Continuous analyte sensor devices and methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5377098A (en) * 1976-12-16 1978-07-08 Sumitomo Chem Co Ltd Preparation of indoloisoquinoline derivative
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
US5441955A (en) * 1993-11-19 1995-08-15 Pathogenesis Corporation Indolo[2,1-biquinazoline-6,12-dione antibacterial compounds and methods of use thereof
FR2743365A1 (fr) * 1996-01-10 1997-07-11 Rhone Poulenc Rorer Sa Derives de 5h,10h-imidazo(1,2-a)indolo(3,2-e)pyrazine-4-one, leur preparation et les medicaments les contenant
US20020040018A1 (en) * 2000-06-23 2002-04-04 Jones Robert M. Subtype selective melatonergics

Also Published As

Publication number Publication date
KR20020072782A (ko) 2002-09-18
FR2821843B1 (fr) 2003-05-09
FR2821843A1 (fr) 2002-09-13
HUP0200913A3 (en) 2004-11-29
NO20021198D0 (no) 2002-03-11
JP3842151B2 (ja) 2006-11-08
CN1375494A (zh) 2002-10-23
HUP0200913A2 (hu) 2002-11-28
KR100450313B1 (ko) 2004-09-30
ZA200202030B (en) 2002-10-03
EP1241169A1 (fr) 2002-09-18
PT1241169E (pt) 2003-11-28
EA200200241A1 (ru) 2002-10-31
BR0200721A (pt) 2002-12-03
CA2376876A1 (fr) 2002-09-12
HU0200913D0 (https=) 2002-05-29
NO20021198L (no) 2002-09-13
PL352750A1 (en) 2002-09-23
NZ517742A (en) 2003-02-28
SI1241169T1 (en) 2003-12-31
HK1049000A1 (en) 2003-04-25
EP1241169B1 (fr) 2003-08-27
AU2324202A (en) 2002-09-19
US6465660B1 (en) 2002-10-15
AU779702B2 (en) 2005-02-10
MXPA02002601A (es) 2004-11-12
DE60200023D1 (de) 2003-10-02
ATE248171T1 (de) 2003-09-15
DK1241169T3 (da) 2003-11-24
ES2206438T3 (es) 2004-05-16
EA004035B1 (ru) 2003-12-25
HK1049000B (zh) 2005-01-07
CA2376876C (fr) 2006-07-11
JP2002265469A (ja) 2002-09-18
DE60200023T2 (de) 2004-06-03
AR034583A1 (es) 2004-03-03

Similar Documents

Publication Publication Date Title
CN1680284A (zh) 阿戈美拉汀的新合成方法、新晶型及其药物组合物
CN1190393A (zh) 二芳基二胺衍生物及其作为δ－阿片样物质(拮抗)激动剂的用途
CN1711260A (zh) 吡啶并嘧啶酮化合物、其制备方法和含有它们的药物
CN85101761A (zh) 新型色胺衍生物的制备方法和应用
CN1159316C (zh) 异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物
CN1100057C (zh) 色烯化合物、其制备方法及含有它们的药物组合物
US6784172B2 (en) Processes for preparation of cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
CN1145896A (zh) 新的烷氧芳基化合物，其制备方法和含有它们的药用组合物
CN1795176A (zh) 作为毒蕈碱受体拮抗剂的氮杂双环衍生物
CN1185214C (zh) 新的茚并吲哚酮化合物,其制备方法和含有这种化合物的药物组合物
CN1136807A (zh) N-取代的氮杂二环庚烷衍生物、它们的制备及应用
CN1250771A (zh) 具有亚环烷基链的新环状化合物,其制备方法和含有它们的药物组合物
CN1139588C (zh) 新的氟化咪唑啉苯并二噁烷,其制备及其治疗用途
CN1809574A (zh) 喹啉3－氨基苯并二氢吡喃衍生物
CN1050358C (zh) 新四环哌嗪和1,4-噁嗪化合物,其制备和药物组合物
CN1671708A (zh) 新的环烷二酮衍生物、它们的制备方法和它们的药物应用
CN1616425A (zh) 新的苯并二氢吲哚化合物、它们的制备方法及含有它们的药物组合物
CN1297439A (zh) 4－(氨基)－(乙氨基)－羟吲哚多巴胺自身受体激动剂
CN1147470C (zh) 新颖2,3,3a,4,9,9a-六氢-8-羟基-1h-苯并[f]吲哚,其制备方法及其作为药物的用途
CN1457337A (zh) 取代的联苯衍生物、制备它们的方法和含有它们的药物组合物
CN1311789A (zh) 具有抗惊厥活性的四氢二氮杂萘－甲酰胺
CN1308069A (zh) 取代的(二氢)苯并噁嗪和(二氢)苯并噻嗪化合物,其制法和药物组合物
CN1555377A (zh) 具有抗精神病药活性的2-(氨甲基)-四氢-9-氧杂-1,3-二氮杂-环戊二烯并[a]萘基衍生物
HK1071896A (en) 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]naphthalenyl derivatives with antipsychotic activity
CN1871223A (zh) 8－氯－2,3－苯二氮䓬衍生物

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1049000

Country of ref document: HK

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20040728

Termination date: 20100312