CN1158283C - 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚 - Google Patents

作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚 Download PDF

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Publication number
CN1158283C
CN1158283C CNB998145971A CN99814597A CN1158283C CN 1158283 C CN1158283 C CN 1158283C CN B998145971 A CNB998145971 A CN B998145971A CN 99814597 A CN99814597 A CN 99814597A CN 1158283 C CN1158283 C CN 1158283C
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CN
China
Prior art keywords
compound
substituted
dihydro
group
pyrrolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB998145971A
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English (en)
Chinese (zh)
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CN1330653A (zh
Inventor
½
陆建春
���з�
克里斯托夫·米舒
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication date
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Publication of CN1330653A publication Critical patent/CN1330653A/zh
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Publication of CN1158283C publication Critical patent/CN1158283C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB998145971A 1998-12-17 1999-12-11 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚 Expired - Fee Related CN1158283C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11265398P 1998-12-17 1998-12-17
US60/112,653 1998-12-17

Publications (2)

Publication Number Publication Date
CN1330653A CN1330653A (zh) 2002-01-09
CN1158283C true CN1158283C (zh) 2004-07-21

Family

ID=22345140

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998145971A Expired - Fee Related CN1158283C (zh) 1998-12-17 1999-12-11 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚

Country Status (17)

Country Link
US (1) US6221867B1 (enExample)
EP (1) EP1149105B1 (enExample)
JP (1) JP2002532503A (enExample)
KR (1) KR20010108024A (enExample)
CN (1) CN1158283C (enExample)
AR (1) AR021695A1 (enExample)
AT (1) ATE387448T1 (enExample)
AU (1) AU767138B2 (enExample)
BR (1) BR9916324A (enExample)
CA (1) CA2354402A1 (enExample)
DE (1) DE69938258T2 (enExample)
ES (1) ES2301255T3 (enExample)
PE (1) PE20001385A1 (enExample)
TR (1) TR200101756T2 (enExample)
UY (1) UY25854A1 (enExample)
WO (1) WO2000035921A1 (enExample)
ZA (1) ZA200104505B (enExample)

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GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
CA2440842A1 (en) 2001-04-16 2002-10-24 Eisai Co., Ltd. Novel 1h-indazole compounds
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
IL159767A0 (en) 2001-07-23 2004-06-20 Applied Research Systems Sulfonamide derivatives, their preparation and pharmacetuical compositions containing them
JP4388376B2 (ja) 2002-02-28 2009-12-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規な縮合環インダゾール化合物
KR20040111445A (ko) 2002-03-28 2004-12-31 에자이 가부시키가이샤 신경퇴행성 질환 치료용 ｃ─Ｊｕｎ Ｎ─말단 키나아제억제제로서의 ７─아자인돌
IL164082A0 (en) 2002-03-28 2005-12-18 Eisai Co Ltd Azaindole derivatives and pharmaceutical compositions containing the same
DE60317198T2 (de) * 2002-05-23 2008-12-04 Cytopia Research Pty. Ltd., Richmond Proteinkinaseinhibitoren
TW200406385A (en) 2002-05-31 2004-05-01 Eisai Co Ltd Pyrazole compound and pharmaceutical composition containing the same
CA2487948A1 (en) 2002-06-14 2003-12-24 Applied Research Systems Ars Holding N.V. Azole methylidene cyanide derivatives and their use as protein kinase modulators
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
WO2004104217A2 (en) * 2003-05-08 2004-12-02 Wyeth Protein kinase c zeta as a drug target for arthritis and other inflammatory diseases
US7612086B2 (en) 2003-05-16 2009-11-03 Eisai R & D Management Co. Ltd. JNK inhibitors
WO2005040116A2 (en) 2003-10-24 2005-05-06 Schering Aktiengesellschaft Indolinone derivatives and their use in treating disease-states such as cancer
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
BRPI0616655A2 (pt) 2005-10-03 2011-06-28 Ono Pharmaceutical Co composto heterocìclico contendo nitrogênio e aplicação farmacêutica do mesmo
JP2009521931A (ja) 2005-12-29 2009-06-11 アントフロゲネシス コーポレーション 胎盤幹細胞を収集及び保存するための改善された組成物、及び該組成物の使用方法

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US4556672A (en) 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
DE3531678A1 (de) 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
CA2037923C (en) 1989-07-25 1996-08-06 Akihiro Kawaguchi Oxindole derivative
FI922347L (fi) 1990-01-05 1992-05-22 Pfizer Azaoxindolderivat.
GB9004483D0 (en) 1990-02-28 1990-04-25 Erba Carlo Spa New aryl-and heteroarylethenylene derivatives and process for their preparation
WO1992007830A2 (en) 1990-10-29 1992-05-14 Pfizer Inc. Oxindole peptide antagonists
GB9115160D0 (en) 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
US5322950A (en) 1991-12-05 1994-06-21 Warner-Lambert Company Imidazole with angiotensin II antagonist properties
FR2694004B1 (fr) 1992-07-21 1994-08-26 Adir Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
GB9226855D0 (en) 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
GB9313638D0 (en) 1993-07-01 1993-08-18 Erba Carlo Spa Arylidene and heteroarylidene oxindole derivatives and process for their preparation
GB9326136D0 (en) 1993-12-22 1994-02-23 Erba Carlo Spa Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents
GB9412719D0 (en) 1994-06-24 1994-08-17 Erba Carlo Spa Substituted azaindolylidene compounds and process for their preparation
GB9423997D0 (en) 1994-11-28 1995-01-11 Erba Carlo Spa Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation
GB9501567D0 (en) 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) * 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
WO1997011692A2 (en) 1995-09-11 1997-04-03 Osteoarthritis Sciences, Inc. Protein tyrosine kinase inhibitors for treating osteoarthritis
US5733920A (en) 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
BR9706973A (pt) 1996-01-11 1999-04-06 Smithkline Beecham Corp Novos compostos de imidazol substituídos
RU2145852C1 (ru) * 1996-01-17 2000-02-27 Тайхо Фармасьютикал Ко., Лтд Ингибитор гипертрофии интимы, применение оксиндолового производного для получения ингибитора гипертрофии интимы, композиция для ингибирования гипертрофии интимы, способ предупреждения и лечения гипертрофии интимы
KR100281867B1 (ko) 1996-01-17 2001-02-15 고바야시 유키오 3-(비스-치환페닐메틸렌)옥신돌유도체
GB9610964D0 (en) 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors
GB9611797D0 (en) 1996-06-06 1996-08-07 Pharmacia Spa Substituted quinolylmethylen-oxindole analogues as tyrosine kinase inhibitors
WO1998007695A1 (en) * 1996-08-23 1998-02-26 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
WO1998024432A2 (en) 1996-12-05 1998-06-11 Sugen, Inc. Use of indolinone compounds as modulators of protein kinases
ATE292623T1 (de) 1997-05-07 2005-04-15 Sugen Inc 2-indolinonderivate als modulatoren der proteinkinase-ativität
GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
JP2002507598A (ja) 1998-03-26 2002-03-12 スージェン・インコーポレーテッド チロシン蛋白質キナーゼを調節するためのヘテロ環式化合物のファミリー
JP2002522452A (ja) 1998-08-04 2002-07-23 スージェン・インコーポレーテッド 蛋白質キナーゼの調節剤３−メチリデニル−２−インドリノン

Also Published As

Publication number Publication date
ZA200104505B (en) 2002-10-04
UY25854A1 (es) 2001-07-31
AR021695A1 (es) 2002-07-31
TR200101756T2 (tr) 2001-10-22
BR9916324A (pt) 2001-10-02
US6221867B1 (en) 2001-04-24
AU767138B2 (en) 2003-10-30
KR20010108024A (ko) 2001-12-07
WO2000035921A1 (en) 2000-06-22
CN1330653A (zh) 2002-01-09
AU1977300A (en) 2000-07-03
EP1149105A1 (en) 2001-10-31
DE69938258D1 (de) 2008-04-10
CA2354402A1 (en) 2000-06-22
ES2301255T3 (es) 2008-06-16
ATE387448T1 (de) 2008-03-15
JP2002532503A (ja) 2002-10-02
PE20001385A1 (es) 2000-12-14
DE69938258T2 (de) 2009-02-26
EP1149105B1 (en) 2008-02-27

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20040721

Termination date: 20100111