CN1158283C - 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚 - Google Patents

作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚 Download PDF

Info

Publication number
CN1158283C
CN1158283C CNB998145971A CN99814597A CN1158283C CN 1158283 C CN1158283 C CN 1158283C CN B998145971 A CNB998145971 A CN B998145971A CN 99814597 A CN99814597 A CN 99814597A CN 1158283 C CN1158283 C CN 1158283C
Authority
CN
China
Prior art keywords
compound
substituted
dihydro
group
pyrrolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB998145971A
Other languages
English (en)
Chinese (zh)
Other versions
CN1330653A (zh
Inventor
½
陆建春
���з�
克里斯托夫·米舒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1330653A publication Critical patent/CN1330653A/zh
Application granted granted Critical
Publication of CN1158283C publication Critical patent/CN1158283C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB998145971A 1998-12-17 1999-12-11 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚 Expired - Fee Related CN1158283C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11265398P 1998-12-17 1998-12-17
US60/112,653 1998-12-17

Publications (2)

Publication Number Publication Date
CN1330653A CN1330653A (zh) 2002-01-09
CN1158283C true CN1158283C (zh) 2004-07-21

Family

ID=22345140

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998145971A Expired - Fee Related CN1158283C (zh) 1998-12-17 1999-12-11 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚

Country Status (17)

Country Link
US (1) US6221867B1 (enExample)
EP (1) EP1149105B1 (enExample)
JP (1) JP2002532503A (enExample)
KR (1) KR20010108024A (enExample)
CN (1) CN1158283C (enExample)
AR (1) AR021695A1 (enExample)
AT (1) ATE387448T1 (enExample)
AU (1) AU767138B2 (enExample)
BR (1) BR9916324A (enExample)
CA (1) CA2354402A1 (enExample)
DE (1) DE69938258T2 (enExample)
ES (1) ES2301255T3 (enExample)
PE (1) PE20001385A1 (enExample)
TR (1) TR200101756T2 (enExample)
UY (1) UY25854A1 (enExample)
WO (1) WO2000035921A1 (enExample)
ZA (1) ZA200104505B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016454D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Thienopyrrolidinones
GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
WO2002083648A1 (fr) 2001-04-16 2002-10-24 Eisai Co., Ltd. Nouveau compose a base de 1h-indazole
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
WO2003010164A1 (en) 2001-07-23 2003-02-06 Applied Research Systems Ars Holding N.V. Arylsulfonamide derivatives as c-jun-n-terminal kinases (jnk's) inhibitors
US7390797B2 (en) 2002-02-28 2008-06-24 Eisai Co., Ltd. Fused indazole compounds
EP1490365B1 (en) 2002-03-28 2010-02-10 Eisai R&D Management Co., Ltd. Azaindoles as inhibitors of c-jun n-terminal kinases
KR20040111445A (ko) 2002-03-28 2004-12-31 에자이 가부시키가이샤 신경퇴행성 질환 치료용 ｃ─Ｊｕｎ Ｎ─말단 키나아제억제제로서의 ７─아자인돌
CA2486183C (en) * 2002-05-23 2012-01-10 Cytopia Pty Ltd. Protein kinase inhibitors
CN1656079A (zh) 2002-05-31 2005-08-17 卫材株式会社 吡唑化合物和含有该化合物的药物组合物
US7465736B2 (en) 2002-06-14 2008-12-16 Laboratoires Serono S.A. Azole methylidene cyanide derivatives and their use as protein kinase modulators
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
JP2007515940A (ja) * 2003-05-08 2007-06-21 ワイス 関節炎及びその他の炎症性疾患の薬物標的としてのプロテインキナーゼｃゼータ
US7612086B2 (en) 2003-05-16 2009-11-03 Eisai R & D Management Co. Ltd. JNK inhibitors
MXPA06004438A (es) 2003-10-24 2006-06-20 Schering Ag Derivados de indolinona y su uso en el tratamiento de enfermedades como el cancer.
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
WO2007040208A1 (ja) 2005-10-03 2007-04-12 Ono Pharmaceutical Co., Ltd. 含窒素複素環化合物およびその医薬用途
US9598669B2 (en) 2005-12-29 2017-03-21 Anthrogenesis Corporation Composition for collecting placental stem cells and methods of using the composition

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
DE3531678A1 (de) 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
CA2037923C (en) 1989-07-25 1996-08-06 Taiho Pharmaceutical Co., Ltd. Oxindole derivative
WO1991009598A1 (en) 1990-01-05 1991-07-11 Pfizer Inc. Azaoxindole derivatives
GB9004483D0 (en) 1990-02-28 1990-04-25 Erba Carlo Spa New aryl-and heteroarylethenylene derivatives and process for their preparation
WO1992007830A2 (en) 1990-10-29 1992-05-14 Pfizer Inc. Oxindole peptide antagonists
GB9115160D0 (en) 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
US5322950A (en) 1991-12-05 1994-06-21 Warner-Lambert Company Imidazole with angiotensin II antagonist properties
FR2694004B1 (fr) 1992-07-21 1994-08-26 Adir Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
GB9226855D0 (en) 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
GB9313638D0 (en) 1993-07-01 1993-08-18 Erba Carlo Spa Arylidene and heteroarylidene oxindole derivatives and process for their preparation
GB9326136D0 (en) 1993-12-22 1994-02-23 Erba Carlo Spa Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents
GB9412719D0 (en) 1994-06-24 1994-08-17 Erba Carlo Spa Substituted azaindolylidene compounds and process for their preparation
GB9423997D0 (en) 1994-11-28 1995-01-11 Erba Carlo Spa Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation
GB9501567D0 (en) 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) * 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
CA2231509C (en) 1995-09-11 2008-07-08 Osteoarthritis Sciences, Inc. Protein tyrosine kinase inhibitors for treating osteoarthritis
US5733920A (en) 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US5756499A (en) 1996-01-11 1998-05-26 Smithkline Beecham Corporation Substituted imidazole compounds
ATE243034T1 (de) * 1996-01-17 2003-07-15 Taiho Pharmaceutical Co Ltd Intimale verdickungsinhibitoren
WO1997026242A1 (en) 1996-01-17 1997-07-24 Taiho Pharmaceutical Co., Ltd. 3-(bis-substituted-phenylmethylene)oxindole derivatives
GB9610964D0 (en) 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors
GB9611797D0 (en) 1996-06-06 1996-08-07 Pharmacia Spa Substituted quinolylmethylen-oxindole analogues as tyrosine kinase inhibitors
EP0929520B1 (en) * 1996-08-23 2005-11-02 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
AU7622698A (en) 1996-12-05 1998-06-29 Sugen, Inc. Use of indolinone compounds as modulators of protein kinases
CA2289102A1 (en) 1997-05-07 1998-11-12 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
WO1999048868A2 (en) 1998-03-26 1999-09-30 Sugen, Inc. Heterocyclic classes of compounds for the modulating tyrosine protein kinase
CA2383623A1 (en) 1998-08-04 2000-02-17 Sugen, Inc. 3-methylidenyl-2-indolinone modulators of protein kinase

Also Published As

Publication number Publication date
AR021695A1 (es) 2002-07-31
AU1977300A (en) 2000-07-03
KR20010108024A (ko) 2001-12-07
US6221867B1 (en) 2001-04-24
ZA200104505B (en) 2002-10-04
CN1330653A (zh) 2002-01-09
JP2002532503A (ja) 2002-10-02
EP1149105B1 (en) 2008-02-27
TR200101756T2 (tr) 2001-10-22
PE20001385A1 (es) 2000-12-14
ES2301255T3 (es) 2008-06-16
CA2354402A1 (en) 2000-06-22
BR9916324A (pt) 2001-10-02
DE69938258T2 (de) 2009-02-26
DE69938258D1 (de) 2008-04-10
AU767138B2 (en) 2003-10-30
WO2000035921A1 (en) 2000-06-22
ATE387448T1 (de) 2008-03-15
UY25854A1 (es) 2001-07-31
EP1149105A1 (en) 2001-10-31

Similar Documents

Publication Publication Date Title
EP3174859B1 (en) Flt3 receptor antagonists
EP4132907B1 (en) (1h-indol-5-yl)acrylamide derivatives as inhibitors of tead proteins and the hippo-yap1/taz signaling cascade for the treatment of cancer
JP7191799B2 (ja) ピリミジン化合物及びその医薬用途
JP5853035B2 (ja) β−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な３，４−ジヒドロ−ピロロ［１，２−ａ］ピラジン−１−イルアミン誘導体
JP2019518776A (ja) Ｅｇｆｒ阻害剤としてのアニリンピリミジン化合物の結晶
EP3740206A1 (en) Inhibitors of cyclin-dependent kinase 7 (cdk7)
CN111615512A (zh) 引起egfr降解的化合物，用于抗癌
KR101211514B1 (ko) 아졸계 키나제 저해제
US6221867B1 (en) 4,5-pyrazinoxindoles
EP2265582B1 (fr) Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.
JP2020506966A (ja) 化合物
CN119119016B (zh) 取代噁二唑类化合物其制备方法和用途
CN1842529A (zh) 用作蛋白激酶抑制剂的化合物和组合物
CN1823062A (zh) 作为5－羟色胺－6配体的磺酰基二氢苯并咪唑酮化合物
EP2294068B1 (fr) DERIVES DE 1,3-DIHYDRO-2H-PYRROLO(3,2-b) PYRIDIN-2-ONE, LEUR PREPARATION ET LEURS APPLICATIONS EN THERAPEUTIQUE
CN1159315C (zh) 4,5-吡咯并羟吲哚
CN102316738A (zh) 作为激酶抑制剂的酰胺类
CN1889949A (zh) PDK－1/Akt信号传导抑制剂
EP1525198A2 (fr) Derives d'acyloxypyrrolidine et leur utilisation en tant que ligands des recepteurs v1b ou v1b et v1a de avp
CN1930131A (zh) 2H－或3H－苯并[e]吲唑－1－基的氨基甲酸酯衍生物、其制备及其在治疗上的应用
AU2009319411B2 (en) Difluorophenyldiacylhydrazide derivatives
JP6227149B2 (ja) 新規のイミダゾリジン−２，４−ジオン誘導体
CN121735905A (zh) 氘代苯甲醇类trpv3抑制剂及其医药用途
MXPA01005932A (es) 4, 5-pirazinoxindoles
HK40042165B (en) Inhibitors of cyclin-dependent kinase 7 (cdk7)

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20040721

Termination date: 20100111