DE69938258T2 - 4,5-pyrazinoxindole als proteinkinasehemmer - Google Patents

4,5-pyrazinoxindole als proteinkinasehemmer Download PDF

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Publication number
DE69938258T2
DE69938258T2 DE69938258T DE69938258T DE69938258T2 DE 69938258 T2 DE69938258 T2 DE 69938258T2 DE 69938258 T DE69938258 T DE 69938258T DE 69938258 T DE69938258 T DE 69938258T DE 69938258 T2 DE69938258 T2 DE 69938258T2
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DE
Germany
Prior art keywords
substituted
radical
aryl
heteroaryl
alkyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69938258T
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German (de)
English (en)
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DE69938258D1 (de
Inventor
Kin-Chun North Caldwell LUK
Christophe New York MICHOUD
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of DE69938258D1 publication Critical patent/DE69938258D1/de
Application granted granted Critical
Publication of DE69938258T2 publication Critical patent/DE69938258T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69938258T 1998-12-17 1999-12-11 4,5-pyrazinoxindole als proteinkinasehemmer Expired - Fee Related DE69938258T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11265398P 1998-12-17 1998-12-17
US112653P 1998-12-17
PCT/EP1999/009806 WO2000035921A1 (en) 1998-12-17 1999-12-11 4,5-pyrazinoxindoles as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
DE69938258D1 DE69938258D1 (de) 2008-04-10
DE69938258T2 true DE69938258T2 (de) 2009-02-26

Family

ID=22345140

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69938258T Expired - Fee Related DE69938258T2 (de) 1998-12-17 1999-12-11 4,5-pyrazinoxindole als proteinkinasehemmer

Country Status (17)

Country Link
US (1) US6221867B1 (enExample)
EP (1) EP1149105B1 (enExample)
JP (1) JP2002532503A (enExample)
KR (1) KR20010108024A (enExample)
CN (1) CN1158283C (enExample)
AR (1) AR021695A1 (enExample)
AT (1) ATE387448T1 (enExample)
AU (1) AU767138B2 (enExample)
BR (1) BR9916324A (enExample)
CA (1) CA2354402A1 (enExample)
DE (1) DE69938258T2 (enExample)
ES (1) ES2301255T3 (enExample)
PE (1) PE20001385A1 (enExample)
TR (1) TR200101756T2 (enExample)
UY (1) UY25854A1 (enExample)
WO (1) WO2000035921A1 (enExample)
ZA (1) ZA200104505B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016454D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Thienopyrrolidinones
GB0108770D0 (en) * 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
AU2002255263B2 (en) 2001-04-16 2006-12-14 Eisai R&D Management Co., Ltd. Novel 1H-indazole compound
US7018999B2 (en) 2001-05-16 2006-03-28 Cephalon, Inc. Methods for the treatment and prevention of pain
ATE419247T1 (de) 2001-07-23 2009-01-15 Serono Lab Arylsulfonamidderivate als hemmer c-jun- terminaler kinasen (jnk)
DE60332215D1 (de) 2002-02-28 2010-06-02 Eisai R&D Man Co Ltd Neue indazolverbindungen mit kondensiertem ring
CA2479205A1 (en) 2002-03-28 2003-10-09 Eisai Co., Ltd. Azaindoles as inhibitors of c-jun n-terminal kinases
CA2480317A1 (en) 2002-03-28 2003-10-09 Eisai Co., Ltd. 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
CN100558715C (zh) * 2002-05-23 2009-11-11 西托匹亚有限公司 蛋白激酶抑制剂
IL164209A0 (en) 2002-05-31 2005-12-18 Eisai Co Ltd Pyrazole derivatives and pharmaceutical compositions containing the same
CA2487948A1 (en) 2002-06-14 2003-12-24 Applied Research Systems Ars Holding N.V. Azole methylidene cyanide derivatives and their use as protein kinase modulators
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
AU2004242105B2 (en) * 2003-05-08 2009-05-28 Wyeth Protein kinase C zeta as a drug target for arthritis and other inflammatory diseases
EP1628975A2 (en) 2003-05-16 2006-03-01 Eisai Co., Ltd. Jnk inhibitors
BRPI0415773A (pt) 2003-10-24 2006-12-26 Schering Ag derivados de indolinona e sua aplicação no tratamento de estados de doença tais como cáncer
US20060094753A1 (en) 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
US7968572B2 (en) 2005-10-03 2011-06-28 Ono Pharmaceuticals Co., Ltd. Nitrogen-containing heterocyclic compound and pharmaceutical application thereof
US9598669B2 (en) 2005-12-29 2017-03-21 Anthrogenesis Corporation Composition for collecting placental stem cells and methods of using the composition

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
DE3531678A1 (de) 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE159718T1 (de) 1989-07-25 1997-11-15 Taiho Pharmaceutical Co Ltd Oxoindolderivate
FI922347A7 (fi) 1990-01-05 1992-05-22 Pfizer Atsaoksindolijohdannaiset
GB9004483D0 (en) 1990-02-28 1990-04-25 Erba Carlo Spa New aryl-and heteroarylethenylene derivatives and process for their preparation
WO1992007830A2 (en) 1990-10-29 1992-05-14 Pfizer Inc. Oxindole peptide antagonists
GB9115160D0 (en) 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
US5322950A (en) 1991-12-05 1994-06-21 Warner-Lambert Company Imidazole with angiotensin II antagonist properties
FR2694004B1 (fr) 1992-07-21 1994-08-26 Adir Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
GB9226855D0 (en) 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
GB9313638D0 (en) 1993-07-01 1993-08-18 Erba Carlo Spa Arylidene and heteroarylidene oxindole derivatives and process for their preparation
GB9326136D0 (en) 1993-12-22 1994-02-23 Erba Carlo Spa Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents
GB9412719D0 (en) 1994-06-24 1994-08-17 Erba Carlo Spa Substituted azaindolylidene compounds and process for their preparation
GB9423997D0 (en) 1994-11-28 1995-01-11 Erba Carlo Spa Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation
GB9501567D0 (en) 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) * 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
WO1997011692A2 (en) 1995-09-11 1997-04-03 Osteoarthritis Sciences, Inc. Protein tyrosine kinase inhibitors for treating osteoarthritis
US5733920A (en) 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
ATE247470T1 (de) 1996-01-11 2003-09-15 Smithkline Beecham Corp Neue substituierte imidazolverbindungen
US5965600A (en) 1996-01-17 1999-10-12 Taiho Pharmaceutical Co., Ltd. 3-(bis-substituted phenylmethylene) oxindole derivatives
KR100264807B1 (ko) * 1996-01-17 2000-09-01 고바야시 유키오 혈관내막비후억제제
GB9610964D0 (en) 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors
GB9611797D0 (en) 1996-06-06 1996-08-07 Pharmacia Spa Substituted quinolylmethylen-oxindole analogues as tyrosine kinase inhibitors
ATE308520T1 (de) * 1996-08-23 2005-11-15 Sugen Inc Kombinatorische bibliotheken von indolinone und verwandte produkte und verfahren zur behandlung von krankheiten
WO1998024432A2 (en) 1996-12-05 1998-06-11 Sugen, Inc. Use of indolinone compounds as modulators of protein kinases
EP0984930B1 (en) 1997-05-07 2005-04-06 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
EP1066257A2 (en) 1998-03-26 2001-01-10 Sugen, Inc. Heterocylic classes of compounds for the modulating tyrosine protein kinase
CA2383623A1 (en) 1998-08-04 2000-02-17 Sugen, Inc. 3-methylidenyl-2-indolinone modulators of protein kinase

Also Published As

Publication number Publication date
UY25854A1 (es) 2001-07-31
DE69938258D1 (de) 2008-04-10
EP1149105B1 (en) 2008-02-27
CA2354402A1 (en) 2000-06-22
TR200101756T2 (tr) 2001-10-22
BR9916324A (pt) 2001-10-02
AU767138B2 (en) 2003-10-30
AR021695A1 (es) 2002-07-31
JP2002532503A (ja) 2002-10-02
KR20010108024A (ko) 2001-12-07
AU1977300A (en) 2000-07-03
ZA200104505B (en) 2002-10-04
ES2301255T3 (es) 2008-06-16
ATE387448T1 (de) 2008-03-15
WO2000035921A1 (en) 2000-06-22
CN1330653A (zh) 2002-01-09
CN1158283C (zh) 2004-07-21
EP1149105A1 (en) 2001-10-31
US6221867B1 (en) 2001-04-24
PE20001385A1 (es) 2000-12-14

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8339 Ceased/non-payment of the annual fee