CN115554212A - Multi-effect skin lotion and preparation method thereof - Google Patents

Multi-effect skin lotion and preparation method thereof Download PDF

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Publication number
CN115554212A
CN115554212A CN202111637466.9A CN202111637466A CN115554212A CN 115554212 A CN115554212 A CN 115554212A CN 202111637466 A CN202111637466 A CN 202111637466A CN 115554212 A CN115554212 A CN 115554212A
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extract
stirring
parts
mixture
sodium
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荣志伟
牛庆华
周卓楠
荣志峰
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Shanghai Guchan Technology Co ltd
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Shanghai Guchan Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
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    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
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    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
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    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention relates to the technical field of cosmetics, wherein IPC (International patent application publication) No. A61K, in particular to a multi-effect moisturizing lotion and a preparation method thereof, deionized water, a chelating agent, a moisturizing agent and a thickening suspending agent are mixed and stirred, a mixture a is prepared after homogenization, a surfactant, an emollient, an antioxidant and an emulsifier are mixed and stirred to prepare a mixture b, the mixture b is added into the mixture a for mixing and stirring homogenization, and a conditioner, a plant extract and a flavoring agent are added into the mixture a for stirring and homogenization to prepare the multi-effect moisturizing lotion.

Description

Multi-effect skin lotion and preparation method thereof
Technical Field
The invention relates to the technical field of cosmetics, has an IPC classification number of A61K, and particularly relates to a multi-effect skin lotion and a preparation method thereof.
Background
The cuticle of the outermost layer of the skin plays an important role in maintaining the barrier function of the skin, a sebum membrane is arranged on the surface of the cuticle, the cuticle is a semitransparent milky membrane formed by emulsifying sebum, sweat and epidermal cell secretion, natural moisturizing factors such as lactate and urea are dissociated in the sebum membrane, the moisture loss of the skin is effectively inhibited, the skin is protected from being damaged by the external environment, if the water content of the cuticle is lower than 10%, the skin can be dry, lack of water and molt, and a proper cosmetic with a moisturizing function is selected, so that the sebum membrane can be formed on the surface of the skin, the moisture evaporation of the skin is effectively prevented, the moisture of the skin is maintained, and the moisturizing effect is achieved.
Patent CN201910275854.3 discloses a whitening and moisturizing emulsion and a preparation method thereof, wherein raw materials for preparation comprise moisturizing grease, an emulsifier, a thickener, glycerol, a surfactant, sodium hyaluronate, a preservative, trehalose, an aloe extract, hydrolyzed collagen and the like, and the prepared moisturizing emulsion has good moisturizing and water locking effects, maintains the moisture and luster of the skin, avoids the skin from being dry and wrinkled, but the molecular weight of the hydrolyzed collagen is too large, and the hydrolyzed collagen is not easy to reach the dermis layer through the skin barrier of a human body and is absorbed by the human body.
Patent CN202010942027.8 discloses a moisturizing emulsion based on ginseng polysaccharide and a preparation method thereof, wherein the preparation raw materials comprise microemulsion, ginseng polysaccharide, preservative and the like, and the prepared moisturizing emulsion has good moisturizing, water locking, antioxidant and anti-aging effects, but has poor physical and chemical stability.
Disclosure of Invention
The invention provides a multi-effect skin lotion, which comprises the following raw materials in parts by weight: 0.1-90 parts of deionized water, 0.01-1 part of chelating agent, 0.1-20 parts of humectant, 0.1-20 parts of antioxidant, 0.1-30 parts of conditioner, 0.1-20 parts of plant extract, 0.1-10 parts of thickening suspending agent, 0.1-10 parts of emulsifier, 0.1-30 parts of emollient, 0.1-10 parts of surfactant and 0.02-1 part of flavoring agent.
Preferably, the chelating agent is disodium EDTA;
preferably, the humectant comprises one or more of glycerin, butanediol, betaine, 1, 2-hexanediol, sodium hyaluronate, methyl glucitol polyether-20, trehalose and chitin derivatives;
preferably, the humectant is a compound of glycerol, butanediol, betaine, 1, 2-hexanediol and sodium hyaluronate, and the mass ratio of the glycerol to the butanediol to the betaine to the 1, 2-hexanediol to the sodium hyaluronate is 1-2:0.5-0.7:0.7-1.2:0.2-0.5:1;
preferably, the antioxidant comprises one or a combination of more of tocopheryl acetate, cysteine, glutathione peroxidase, papain and metallothionein;
further preferably, the antioxidant is tocopherol acetate;
preferably, the conditioning agent comprises one or more of niacinamide, arbutin, tranexamic acid, bisabolol, ceramide AP, hydrogenated lecithin, cholesterol, ceramide NP, ceramide EOP, panthenol, allantoin, p-hydroxyacetophenone, ethylhexyl palmitate, tetrahydromethylpyrimidine carboxylic acid and propylene glycol dibenzoate;
further preferably, the conditioning agent is nicotinamide, arbutin, tranexamic acid, the combination of bisabolol, ceramide AP, hydrogenated lecithin, cholesterol, ceramide NP, ceramide EOP, panthenol, allantoin and p-hydroxyacetophenone, the mass ratio of nicotinamide, arbutin, tranexamic acid, bisabolol, ceramide AP, hydrogenated lecithin, cholesterol, ceramide NP, ceramide EOP, panthenol, allantoin and p-hydroxyacetophenone is 1.3-1.7:0.3-0.7:0.7-1.4:0.8-1.2:0.3-1.5:0.4-0.7:0.7-1:0.8-1.4:1.3-1.7:0.4-0.7:0.7-1:0.1-0.3;
preferably, the plant extract comprises one or more of GLYCYRRHIZA inflate root extract, scutellaria baicalensis root extract, sophora flavescens root extract, centella asiatica extract, oat kernel extract, GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA) root extract, grape extract, polygonum cuspidatum extract and peony flower extract;
further preferably, the plant extract is a compound of an extract of GLYCYRRHIZA inflate linn root, an extract of scutellaria baicalensis root, an extract of sophora flavescens linn root, an extract of oat kernel, an extract of centella asiatica, and an extract of GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA) root, wherein the mass ratio of the extract of GLYCYRRHIZA inflate linn root, the extract of scutellaria baicalensis root, the extract of sophora flavescens linn root, the extract of oat kernel, the extract of centella asiatica, and the extract of GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA) root is 0.8-1.7:0.5-0.7:1.7-2.0:0.4-1:0.3-0.7:1-2;
preferably, the thickening suspending agent comprises one or a combination of more of xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate, polyacrylate cross-linked polymer-6 and dipotassium glycyrrhizinate;
further preferably, the thickening suspending agent is a compound of xanthan gum and sodium acrylate/sodium acryloyldimethyl taurate, and the mass ratio of the xanthan gum to the sodium acrylate/sodium acryloyldimethyl taurate is 0.5-1.3:0.8 to 1.5;
preferably, the emulsifier comprises one or more of C12-20 alkyl glucoside, C14-22 alcohol, glyceryl stearate, laureth-23, steareth-21 and sorbitan laurate;
more preferably, the emulsifier is a compound of C12-20 alkyl glucoside, C14-22 alcohol and glycerol stearate, and the mass ratio of the C12-20 alkyl glucoside to the C14-22 alcohol to the glycerol stearate is 0.6-1.1:0.3-0.7:0.5-0.9;
preferably, the emollient comprises one or more of olive oil, sunflower seed oil, cetostearyl alcohol, polydimethylsiloxane, shea butter, jojoba oil, squalane, caprylic/capric triglyceride, geranium essential oil, jasmine essential oil, and fennel essential oil;
further preferably, the emollient is olive oil, sunflower seed oil, cetearyl alcohol, polydimethylsiloxane, shea butter, jojoba seed oil; squalane, caprylic/capric triglyceride, olive oil, sunflower seed oil, cetostearyl alcohol, polydimethylsiloxane, shea butter, jojoba seed oil; the mass ratio of squalane to caprylic/capric triglyceride is 0.4-0.8:1.2-2:0.5-1.6:0.4-0.9:0.3-0.7:1-2:0.4-1.5:0.3-0.9;
preferably, the surfactant comprises one or more of sodium stearoyl glutamate, glucoside, sodium methyl cocoyl taurate, citrate and sodium laureth-11 carboxylate;
further preferably, the surfactant is sodium stearoyl glutamate;
preferably, the flavoring agent is a perfume.
The invention provides a preparation method of multi-effect skin lotion, which comprises the following steps:
(1) Adding deionized water into a reaction device, adding a chelating agent, a humectant and a thickening suspending agent, mixing and stirring for 30-50min at a stirring speed of 5000-7000r/min, then homogenizing for 3-5min, continuously heating in the stirring and homogenizing process, and stopping heating and preserving heat when the temperature in the reaction device reaches 80-90 ℃ to obtain a mixture a;
(2) Adding surfactant, emollient, antioxidant, and emulsifier into another reaction device, stirring and heating at stirring speed of 500-700r/min, continuously heating during stirring, and stopping stirring and maintaining temperature after the temperature of the reaction device is increased to 80-90 deg.C and stirring for 20-30min to obtain mixture b;
(3) Adding the mixture b into the mixture a, mixing and stirring at the stirring speed of 500-700r/min for 10-15min, then adjusting the stirring speed to 5000-7000r/min, continuing stirring for 30-45min, and then homogenizing for 8-10min to obtain a mixture c;
(4) And when the temperature of the mixture c is reduced to 45-55 ℃, adding the conditioner, the plant extract and the flavoring agent, adjusting the stirring speed to 4000-8000r/min, continuously stirring for 10-15min, homogenizing for 3-5min, adjusting the stirring speed to 300-650r/min, continuously stirring for 10-15min, cooling to room temperature, stopping stirring, and discharging to obtain the product.
Has the advantages that:
(1) The multi-effect skin lotion is prepared by mixing deionized water, a chelating agent, a humectant and a thickening suspending agent to obtain a mixture a, mixing a surfactant, an emollient, an antioxidant and an emulsifier to obtain a mixture b, and mixing the mixture a and the mixture b with a conditioner, a plant extract and a flavoring agent.
(2) The applicant finds that by adding tocopherol acetate as an antioxidant, nicotinamide, arbutin, tranexamic acid, bisabolol, ceramide AP, hydrogenated lecithin, cholesterol, ceramide NP, ceramide EOP, panthenol, allantoin, a combination of p-hydroxyacetophenone, nicotinamide, arbutin, tranexamic acid, bisabolol, ceramide AP, hydrogenated lecithin, cholesterol, ceramide NP, ceramide EOP, panthenol, allantoin, p-hydroxyacetophenone, the mass ratio of 1.3-1.7:0.3-0.7:0.7-1.4:0.8-1.2:0.3-1.5:0.4-0.7:0.7-1:0.8-1.4:1.3-1.7:0.4-0.7:0.7-1:0.1-0.3, the plant extract is a compound of an extract of the root of GLYCYRRHIZA inflata, an extract of the root of scutellaria baicalensis georgi, an extract of the root of sophora flavescens, an extract of oat kernel, an extract of centella asiatica, and an extract of the root of GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA), and the mass ratio of the extract of the root of GLYCYRRHIZA inflata, the extract of the root of scutellaria baicalensis georgi, the extract of the root of sophora flavescens, the extract of oat kernel, the extract of centella asiatica, and the extract of the root of GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA) is 0.8-1.7:0.5-0.7:1.7-2.0:0.4-1:0.3-0.7:1-2, the physical and chemical stability of the prepared moisturizing lotion can be improved, active groups in the antioxidant are closely adsorbed with active ingredients in a conditioner and a plant extract through intermolecular interaction to form a stable coating structure, the oxidation of the active ingredients is inhibited, and meanwhile, toxic peroxide is reduced into a non-toxic hydroxyl compound to inhibit the damage of the peroxide to a skin cell membrane structure.
(3) The multifunctional skin lotion is prepared by mixing and stirring deionized water, a chelating agent, a humectant and a thickening suspending agent, homogenizing to prepare a mixture a, mixing and stirring a surfactant, an emollient, an antioxidant and an emulsifier to prepare a mixture b, adding the mixture b into the mixture a, mixing and stirring to homogenize, adding a conditioner, a plant extract and a flavoring agent, stirring and homogenizing, and preparing the multifunctional skin lotion which has the excellent effects of long-acting deep skin moistening, fine skin feeling, mild and sensitive skin, refreshing and no irritation and the like.
Detailed Description
Example 1
Embodiment 1 provides a multi-effect skin lotion, which comprises the following raw materials in parts by weight: 60 parts of deionized water, 0.5 part of chelating agent, 10 parts of humectant, 2 parts of antioxidant, 12 parts of conditioner, 9 parts of plant extract, 2 parts of thickening suspending agent, 2 parts of emulsifier, 10 parts of emollient, 2 parts of surfactant and 0.4 part of flavoring agent.
The chelating agent is disodium EDTA, and the CAS number of the disodium EDTA is 6381-92-6;
the humectant is a compound of glycerol, butanediol, betaine, 1, 2-hexanediol and sodium hyaluronate, and the mass ratio of the glycerol, the butanediol, the betaine, the 1, 2-hexanediol and the sodium hyaluronate is 1:0.5:0.7:0.2:1, the CAS number of glycerol is 56-81-5, the CAS number of butanediol is 19132-06-0, the CAS number of betaine is 107-43-7, the CAS number of 1, 2-hexanediol is 6920-22-5, and the CAS number of sodium hyaluronate is 9067-32-7;
the antioxidant is tocopherol acetate, and the CAS number of the tocopherol acetate is 7695-91-2;
the conditioner is prepared from nicotinamide, arbutin, tranexamic acid, bisabolol, ceramide AP, hydrogenated lecithin, cholesterol, ceramide NP, ceramide EOP, panthenol, allantoin and p-hydroxyacetophenone in a mass ratio of 1.3:0.3:0.7:0.8:0.3:0.4:0.7:0.8:1.3:0.4:0.7:0.1, 98-92-0 parts of nicotinamide CAS number, 497-76-7 parts of arbutin CAS number, 1197-18-8 parts of tranexamic acid CAS number, 515-69-5 parts of bisabolol CAS number, 92128-87-5 parts of hydrogenated lecithin CAS number, 57-88-5 parts of cholesterol CAS number, 16485-10-2 parts of panthenol CAS number, 97-59-6 parts of allantoin CAS number and 99-93-4 parts of p-hydroxyacetophenone CAS number;
the plant extract is a compound of a GLYCYRRHIZA inflate root extract, a scutellaria baicalensis root extract, a sophora flavescens root extract, an oat kernel extract, a centella asiatica extract and a GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA) root extract, and the mass ratio of the GLYCYRRHIZA inflate root extract, the scutellaria baicalensis root extract, the sophora flavescens root extract, the oat kernel extract, the centella asiatica extract and the GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA) root extract is 0.8:0.5:1.7:0.4:0.3:1, the GLYCYRRHIZA inflata latin named GLYCYRRHIZA flatacalin, the GLYCYRRHIZA inflata root extract is obtained from kam biosciences ltd, shanghai, scutellaria baicalensis root extract CAS No. 94279-99-9, scutellaria baicalensis latin named scutellaria basiensis georgi, sophorae radix sophorae extract No. YS-3016, west ann major biosciences ltd, sophorae falvescentis named sophorae No., avena sativa L, oat kernel extract CAS No. 84012-26-0, centella asiatica extract No. 84696-21-9, centella asiatica latin named centella asiatica (L.) urba, GLYCYRRHIZA GLABRA named GLYCYRRHIZA latin L, GLYCYRRHIZA GLABRA (GLYCYRRHIZA abra) root extract No. glc 775-66-6;
the thickening suspending agent is a compound of xanthan gum and sodium acrylate/sodium acryloyldimethyl taurate, and the mass ratio of the xanthan gum to the sodium acrylate/sodium acryloyldimethyl taurate is 0.5:0.8, the CAS number of xanthan gum is 11138-66-2, the CAS number of sodium acrylate/sodium acryloyldimethyltaurate copolymer is 37350-42-8, the sodium acrylate/sodium acryloyldimethyltaurate copolymer is a polymer of a sodium 2-acrylate salt and a monosodium 2-methyl-2- [ (1-oxo-2-propenyl) amino ] -1-propanesulfonate salt;
the emulsifier is a compound of C12-20 alkyl glucoside, C14-22 alcohol and glycerol stearate, wherein the mass ratio of the C12-20 alkyl glucoside to the C14-22 alcohol to the glycerol stearate is 0.6:0.3:0.5 C12-20 alkyl glucoside, available from Shanghai Saifu chemical Co., ltd., C14-22 alcohol, available from Shanghai Saifu chemical Co., ltd., glyceryl stearate, CAS number 85666-92-8, available from Jincony chemical Co., ltd.;
the emollient is olive fruit oil, sunflower seed oil, cetostearyl alcohol, polydimethylsiloxane, shea butter, jojoba seed oil, squalane, caprylic/capric triglyceride, olive fruit oil, sunflower seed oil, cetostearyl alcohol, polydimethylsiloxane, shea butter, jojoba seed oil; the mass ratio of squalane to caprylic/capric triglyceride is 0.4:1.2:0.5:0.4:0.3:1:0.4:0.3, the CAS number of the olive fruit oil is 8001-25-0, the olive fruit oil is olive oil, the sunflower seed oil CAS number is 8001-21-6, the cetearyl alcohol CAS number is 67762-27-0, the dimethicone CAS number is 9016-00-6, the shea butter number is TFSW, purchased from sikan toyoho biotechnology limited, the jojoba seed oil brand kangqiong, purchased from wuhan kangqiong biomedical science and technology limited, the squalane CAS number is 111-01-3, the caprylic/capric triglyceride CAS number is 65381-09-1;
the surfactant is sodium stearoyl glutamate, and the CAS number of the sodium stearoyl glutamate is 38517-23-6;
the flavoring agent is essence, and the CAS number of the essence is 8023-88-9.
The invention provides a preparation method of multi-effect skin lotion, which comprises the following steps:
(1) Adding ionized water into a reaction device, adding a chelating agent, a humectant and a thickening suspending agent, mixing and stirring for 30min, stirring at a rotation speed of 5000r/min, homogenizing for 3min, continuously heating in the stirring and homogenizing process, and stopping heating and preserving heat when the temperature in the reaction device reaches 80 ℃ to obtain a mixture a;
(2) Adding a surfactant, an emollient, an antioxidant and an emulsifier into another reaction device, stirring and heating at the stirring speed of 500r/min, continuously heating during stirring, and when the temperature of the reaction device rises to 80 ℃, continuing stirring for 20min, stopping stirring and preserving heat to obtain a mixture b;
(3) Adding the mixture b into the mixture a, mixing and stirring at the stirring speed of 500r/min for 10min, then adjusting the stirring speed to 5000r/min, continuing stirring for 30min, and then homogenizing for 8min to obtain a mixture c;
(4) And (3) when the temperature of the mixture c is reduced to 45 ℃, adding a conditioner, a plant extract and a flavoring agent, adjusting the stirring speed to 4000r/min, continuously stirring for 10min, homogenizing for 3min, adjusting the stirring speed to 300r/min, continuously stirring for 10min, cooling to room temperature, stopping stirring, and discharging to obtain the product.
Example 2
Embodiment 2 provides a multi-effect skin lotion, which is prepared from the following raw materials in parts by weight: 70 parts of deionized water, 0.7 part of chelating agent, 15 parts of humectant, 4 parts of antioxidant, 18 parts of conditioner, 15 parts of plant extract, 3 parts of thickening suspending agent, 3 parts of emulsifier, 18 parts of emollient, 3 parts of surfactant and 0.5 part of flavoring agent.
The chelating agent is disodium EDTA, and the CAS number of the disodium EDTA is 6381-92-6;
the humectant is a compound of glycerol, butanediol, betaine, 1, 2-hexanediol and sodium hyaluronate, and the mass ratio of the glycerol, the butanediol, the betaine, the 1, 2-hexanediol and the sodium hyaluronate is 1.5:0.6:1:0.4:1, the CAS number of glycerol is 56-81-5, the CAS number of butanediol is 19132-06-0, the CAS number of betaine is 107-43-7, the CAS number of 1, 2-hexanediol is 6920-22-5, and the CAS number of sodium hyaluronate is 9067-32-7;
the antioxidant is tocopherol acetate, and the CAS number of the tocopherol acetate is 7695-91-2;
the conditioner is prepared from nicotinamide, arbutin, tranexamic acid, bisabolol, ceramide AP, hydrogenated lecithin, cholesterol, ceramide NP, ceramide EOP, panthenol, allantoin and p-hydroxyacetophenone in a mass ratio of 1.5:0.5:1:1:1.3:0.6:0.9:1.2:1.5:0.5:0.8:0.3, the CAS number of nicotinamide is 98-92-0, the CAS number of arbutin is 497-76-7, the CAS number of tranexamic acid is 1197-18-8, the CAS number of bisabolol is 515-69-5, the CAS number of hydrogenated lecithin is 92128-87-5, the CAS number of cholesterol is 57-88-5, the CAS number of panthenol is 16485-10-2, the CAS number of allantoin is 97-59-6, and the CAS number of p-hydroxyacetophenone is 99-93-4;
the plant extract is a compound of a GLYCYRRHIZA inflate root extract, a scutellaria baicalensis root extract, a sophora flavescens root extract, an oat kernel extract, a centella asiatica extract and a GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA) root extract, and the mass ratio of the GLYCYRRHIZA inflate root extract, the scutellaria baicalensis root extract, the sophora flavescens root extract, the oat kernel extract, the centella asiatica extract and the GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA) root extract is 1.4:0.6:1.9:0.7:0.5:1.5, the GLYCYRRHIZA inflata latin is GLYCYRRHIZA inflatabatin, the GLYCYRRHIZA inflata root extract is purchased from Shanghai Jia Kai Biotech limited, the CAS number of the scutellaria root extract is 94279-99-9, the scutellaria root latin is Scutellaria basilica Georgi, the picrashium root extract model is YS-3016, the Sophoraflavoscens ait, the Avena latifolia is Avena sativa L, the oat kernel extract CAS number is 84012-26-0, the centella asiatica extract number is 84696-21-9, the centella asiatica latin is Centellasiatia (L.) Urb., the GLYCYRRHIZA inflatan is Glycyrrhiza GLABRA L, and the GLYCYRRHIZA GLABRA (Glycyrrhiza abra) root extract number is CAS 66-7756-846;
the thickening suspending agent is a compound of xanthan gum and sodium acrylate/sodium acryloyldimethyl taurate, and the mass ratio of the xanthan gum to the sodium acrylate/sodium acryloyldimethyl taurate is 1:1.3, xanthan gum has CAS number of 11138-66-2, and sodium acrylate/sodium acryloyldimethyl taurate copolymer has CAS number of 37350-42-8, and the sodium acrylate/sodium acryloyldimethyl taurate copolymer is a polymer of 2-acrylic acid sodium salt and 2-methyl-2- [ (1-oxo-2-propenyl) amino ] -1-propanesulfonic acid monosodium salt;
the emulsifier is a compound of C12-20 alkyl glucoside, C14-22 alcohol and glycerol stearate, wherein the mass ratio of the C12-20 alkyl glucoside to the C14-22 alcohol to the glycerol stearate is 0.9:0.5:0.7 C12-20 alkyl glucoside, available from Shanghai Saifu chemical Co., ltd., C14-22 alcohol, available from Shanghai Saifu chemical Co., ltd., glyceryl stearate, CAS number 85666-92-8, available from Jincony chemical Co., ltd.;
the emollient is olive fruit oil, sunflower seed oil, cetostearyl alcohol, polydimethylsiloxane, shea butter, jojoba seed oil, squalane, caprylic/capric triglyceride, olive fruit oil, sunflower seed oil, cetostearyl alcohol, polydimethylsiloxane, shea butter, jojoba seed oil; the mass ratio of squalane to caprylic/capric triglyceride is 0.6:1.7:1.2:0.6:0.5:1.5:1:0.7, the CAS number of the olive fruit oil is 8001-25-0, the olive fruit oil is olive oil, the sunflower seed oil CAS number is 8001-21-6, the cetearyl alcohol CAS number is 67762-27-0, the dimethicone CAS number is 9016-00-6, the shea butter number is TFSW, purchased from sikan toyoho biotechnology limited, the jojoba seed oil brand kangqiong, purchased from wuhan kangqiong biomedical science and technology limited, the squalane CAS number is 111-01-3, the caprylic/capric triglyceride CAS number is 65381-09-1;
the surfactant is sodium stearoyl glutamate with CAS number of 38517-23-6; the flavoring agent is essence, and the CAS number of the essence is 8023-88-9.
The invention provides a preparation method of multi-effect skin lotion in a second aspect, which comprises the following steps:
(1) Adding deionized water into a reaction device, adding a chelating agent, a humectant and a thickening suspending agent, mixing and stirring for 40min, stirring at a rotating speed of 6000r/min, homogenizing for 4min, continuously heating in the stirring and homogenizing process, and stopping heating and heat preservation when the temperature in the reaction device reaches 85 ℃ to obtain a mixture a;
(2) Adding a surfactant, an emollient, an antioxidant and an emulsifier into another reaction device, stirring and heating at the stirring speed of 600r/min, continuously heating during stirring, and when the temperature of the reaction device rises to 85 ℃, continuing stirring for 25min, stopping stirring and preserving heat to obtain a mixture b;
(3) Adding the mixture b into the mixture a, mixing and stirring at the stirring speed of 600r/min for 13min, then adjusting the stirring speed to 6000r/min, continuing stirring for 40min, and then homogenizing for 9min to obtain a mixture c;
(4) And (3) when the temperature of the mixture c is reduced to 50 ℃, adding a conditioner, the plant extract and a flavoring agent, adjusting the stirring speed to 6000r/min, continuing stirring for 13min, homogenizing for 4min, adjusting the stirring speed to 500r/min, stirring for 12min, cooling to room temperature, stopping stirring, and discharging to obtain the product.
Comparative example 1
The specific implementation manner is the same as that in example 2, except that the multi-effect skin lotion is prepared from the following raw materials, by weight, 70 parts of deionized water, 0.7 part of chelating agent, 15 parts of humectant, 18 parts of conditioner, 15 parts of plant extract, 3 parts of thickening suspending agent, 3 parts of emulsifier, 18 parts of emollient, 3 parts of surfactant and 0.5 part of flavoring agent.
Comparative example 2
The specific implementation manner is the same as that in example 2, except that the conditioning agent is nicotinamide, arbutin, tranexamic acid, bisabolol, ceramide AP, hydrogenated lecithin, cholesterol, ceramide NP, ceramide EOP, panthenol, allantoin, a compound of p-hydroxyacetophenone, nicotinamide, arbutin, tranexamic acid, bisabolol, ceramide AP, hydrogenated lecithin, cholesterol, ceramide NP, ceramide EOP, panthenol, allantoin, and p-hydroxyacetophenone, and the mass ratio of the bisabolol, the ceramide AP, the hydrogenated lecithin, the cholesterol, the ceramide NP, the ceramide EOP, the panthenol, the allantoin and the p-hydroxyacetophenone is 0.2:0.3:0.5:0.4:0.1:0.2:0.3:0.3:0.5:0.2:0.4:0.1, 98-92-0 parts of nicotinamide CAS number, 497-76-7 parts of arbutin CAS number, 1197-18-8 parts of tranexamic acid CAS number, 515-69-5 parts of bisabolol CAS number, 92128-87-5 parts of hydrogenated lecithin CAS number, 57-88-5 parts of cholesterol CAS number, 16485-10-2 parts of panthenol CAS number, 97-59-6 parts of allantoin CAS number and 99-93-4 parts of p-hydroxyacetophenone CAS number.
Comparative example 3
The specific implementation manner is the same as example 2, except that the plant extract is a combination of an extract of GLYCYRRHIZA inflate maxim root, an extract of scutellaria baicalensis georgi root, an extract of sophora flavescens root, an extract of oat kernel, an extract of centella asiatica (GLYCYRRHIZA GLABRA) root, and the mass ratio of the extract of GLYCYRRHIZA inflate maxim root, the extract of scutellaria baicalensis root, the extract of sophora flavescens root, the extract of oat kernel, the extract of centella asiatica, and the extract of GLYCYRRHIZA GLABRA (GLYCYRRHIZA GLABRA) root is 0.8:0.2:0.3:0.1:0.2:0.4, the GLYCYRRHIZA inflate extract is obtained from Shanghai Jia Kai Biotech Co., ltd, the CAS number of the scutellaria baicalensis root extract is 94279-99-9, the scutellaria baicalensis latin is Scutellaria basiensis Georgi, the picrorhiza kurroa extract is model number YS-3016, the Xian Youhao Biotech Co., ltd, the sophora flavescens latin is Sophoraflavescens Ait, the oat latin is Avena sativa L, the oat kernel extract CAS number is 84012-26-0, the centella asiatica extract number is 84696-21-9, the centella asiatica is Centellaasitia (L.) Urb., the GLYCYRRHIZA GLABRA is Glycyrrhiza riza L, and the GLYCYRRHIZA GLABRA (GLYCYRYRYRRZA GLABRA) root extract number is 84775-66-6;
and (3) performance testing:
according to the GB/T29665-2013 skin care emulsion standard, the multi-effect skin care emulsion prepared in the examples 1-2 and the comparative examples 1-3 is subjected to tests on microbial indexes, toxic substance limit, sensory indexes and physical and chemical indexes.
Figure BDA0003442826040000101
Figure BDA0003442826040000111

Claims (10)

1. The multi-effect skin lotion is characterized by comprising the following preparation raw materials in parts by weight: 0.1-90 parts of deionized water, 0.01-1 part of chelating agent, 0.1-20 parts of humectant, 0.1-20 parts of antioxidant, 0.1-30 parts of conditioner, 0.1-20 parts of plant extract, 0.1-10 parts of thickening suspending agent, 0.1-10 parts of emulsifier, 0.1-30 parts of emollient, 0.1-10 parts of surfactant and 0.02-1 part of flavoring agent.
2. The multi-effect skin lotion according to claim 1, wherein the moisturizer comprises one or more of glycerin, butylene glycol, betaine, 1, 2-hexanediol, sodium hyaluronate, methyl gluceth-20, trehalose, and chitin derivatives.
3. The multi-effect skin lotion of claim 1, wherein the antioxidant comprises one or more of tocopheryl acetate, cysteine, glutathione peroxidase, papain, metallothionein.
4. The multi-effect skin lotion of claim 1, wherein the conditioning agent comprises one or more of niacinamide, arbutin, tranexamic acid, bisabolol, ceramide AP, hydrogenated lecithin, cholesterol, ceramide NP, ceramide EOP, panthenol, allantoin, p-hydroxyacetophenone, ethylhexyl palmitate, tetrahydromethylpyrimidine carboxylic acid, propylene glycol dibenzoate.
5. The multi-effect skin lotion of claim 1, wherein the plant extract comprises one or more of an extract of glycyrrhiza inflate, an extract of scutellaria baicalensis roots, an extract of sophora flavescens roots, an extract of centella asiatica, an extract of oat kernel, an extract of glycyrrhiza glabra roots, an extract of grapes, an extract of polygonum cuspidatum, and an extract of peony.
6. The multi-effect emollient milk of claim 1, wherein said thickening and suspending agent comprises one or a combination of xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate, polyacrylate cross-linked polymer-6, dipotassium glycyrrhizinate.
7. The multi-effect skin lotion of claim 1, wherein the emulsifier comprises one or more of C12-20 alkyl glucoside, C14-22 alcohol, glyceryl stearate, laureth-23, steareth-21, and sorbitan laurate.
8. The multi-effect emollient milk of claim 1, wherein said emollient comprises one or a combination of olive oil, sunflower seed oil, cetearyl alcohol, dimethicone, shea butter, jojoba seed oil, squalane, caprylic/capric triglyceride, geranium essential oil, jasmine essential oil, anise essential oil.
9. The multi-effect emollient milk of claim 1, wherein said surfactant comprises one or more of sodium stearoyl glutamate, glucoside, sodium methyl cocoyl taurate, citrate, sodium laureth-11 carboxylate.
10. A method for preparing the multi-effect skin lotion according to any one of claims 1-9, comprising the following steps:
(1) Adding deionized water into a reaction device, adding a chelating agent, a humectant and a thickening suspending agent, mixing and stirring for 30-50min at a stirring speed of 5000-7000r/min, then homogenizing for 3-5min, continuously heating in the stirring and homogenizing process, and stopping heating and preserving heat when the temperature in the reaction device reaches 80-90 ℃ to obtain a mixture a;
(2) Adding a surfactant, an emollient, an antioxidant and an emulsifier into another reaction device, stirring and heating at the stirring speed of 500-700r/min, continuously heating during stirring, and when the temperature of the reaction device rises to 80-90 ℃, continuously stirring for 20-30min, stopping stirring and preserving heat to obtain a mixture b;
(3) Adding the mixture b into the mixture a, mixing and stirring at the stirring speed of 500-700r/min for 10-15min, then adjusting the stirring speed to 5000-7000r/min, continuing stirring for 30-45min, and then homogenizing for 8-10min to obtain a mixture c;
(4) And (3) when the temperature of the mixture c is reduced to 45-55 ℃, adding a conditioner, a plant extract and a flavoring agent, adjusting the stirring speed to 4000-8000r/min, continuously stirring for 10-15min, homogenizing for 3-5min, adjusting the stirring speed to 300-650r/min, continuously stirring for 10-15min, cooling to room temperature, stopping stirring, and discharging to obtain the product.
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