CN114732760A - Supermolecule fat milk glycerol glucoside composition, preparation method and application thereof, moisturizing skin care milk and moisturizing essence - Google Patents
Supermolecule fat milk glycerol glucoside composition, preparation method and application thereof, moisturizing skin care milk and moisturizing essence Download PDFInfo
- Publication number
- CN114732760A CN114732760A CN202210475204.5A CN202210475204A CN114732760A CN 114732760 A CN114732760 A CN 114732760A CN 202210475204 A CN202210475204 A CN 202210475204A CN 114732760 A CN114732760 A CN 114732760A
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- China
- Prior art keywords
- parts
- moisturizing
- glycerol glucoside
- long
- composition
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title claims abstract description 160
- 239000000203 mixture Substances 0.000 title claims abstract description 70
- 229930182478 glucoside Natural products 0.000 title claims abstract description 69
- -1 glycerol glucoside Chemical class 0.000 title claims abstract description 69
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 38
- 235000013336 milk Nutrition 0.000 title claims abstract description 37
- 239000008267 milk Substances 0.000 title claims abstract description 37
- 210000004080 milk Anatomy 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 230000014759 maintenance of location Effects 0.000 claims abstract description 17
- 239000002537 cosmetic Substances 0.000 claims abstract description 10
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims abstract description 9
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 9
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 claims abstract description 9
- 239000004359 castor oil Substances 0.000 claims abstract description 9
- 235000019438 castor oil Nutrition 0.000 claims abstract description 9
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 9
- 229940083466 soybean lecithin Drugs 0.000 claims abstract description 9
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract description 7
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 6
- 239000012071 phase Substances 0.000 claims description 44
- 235000019197 fats Nutrition 0.000 claims description 30
- 238000003756 stirring Methods 0.000 claims description 25
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 13
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- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 12
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- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 11
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- CLAHOZSYMRNIPY-UHFFFAOYSA-N 2-hydroxyethylurea Chemical compound NC(=O)NCCO CLAHOZSYMRNIPY-UHFFFAOYSA-N 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
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- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 claims description 6
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- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 3
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- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 3
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- 229940069521 aloe extract Drugs 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
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- 229920006037 cross link polymer Polymers 0.000 claims description 3
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- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims description 3
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- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 3
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- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 3
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- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
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- 229940082509 xanthan gum Drugs 0.000 claims description 3
- AMUTYVGRCVFCCD-UHFFFAOYSA-N 5,6-diaminopyridine-3-carboxylic acid Chemical compound NC1=CC(C(O)=O)=CN=C1N AMUTYVGRCVFCCD-UHFFFAOYSA-N 0.000 claims description 2
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- 235000019486 Sunflower oil Nutrition 0.000 claims description 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 2
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention relates to the technical field of cosmetics, and discloses a supermolecular fat milk glycerol glucoside composition with long-acting and high moisture retention performance, and a preparation method and application thereof. The composition comprises the following components: 1-30 parts of oily functional components, 0.1-5 parts of soybean lecithin, 0.1-8 parts of PEG-40 hydrogenated castor oil, 3-5 parts of pentanediol, 0.01-2 parts of tocopherol acetate, 0.01-2 parts of sodium oleate, 0.01-2 parts of EDTA-2Na, 0.1-5 parts of glycerol glucoside and 30-80 parts of water. The composition can remarkably prolong the duration of moisturizing effect while enhancing the moisturizing effect by the synergistic effect of the supermolecule technology of nano-encapsulated oily components and the water-soluble component glycerol glucoside, and provides long-acting high moisturizing effect and fresh and non-greasy skin feeling.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a preparation method and application of a long-acting high-moisture supermolecule fat milk glycerol glucoside composition.
Background
At present, moisturizing skin care products on the market comprise water, cream, milk, oil and the like, wherein the components playing a moisturizing role are many and are generally divided into two types, one type is a water-soluble humectant, such as polyhydric alcohols: propylene glycol, butylene glycol, sodium lactate, sorbitol, etc.; the other type is an oil-soluble humectant, such as squalane, grape seed oil, silicone oil and other oily raw materials, which mainly forms a film by covering the surface of the skin to prevent the skin from moisture evaporation and the like to play a role in moisturizing the skin. None of these ingredients is coated, the aqueous ingredients cannot maintain a long-lasting moisturizing effect due to their strong volatility, while the oily ingredients provide a very sticky skin feel when applied on the skin due to the oily nature, which can be perceived by the user as excessively greasy and draggy , and are not easily absorbed by the skin.
Therefore, a novel cosmetic composition which is fresh, cool and non-greasy and has strong moisturizing effect and long time is increasingly popular, and the supermolecule technology of nano-encapsulated oily components and the water-soluble component glycerol glucoside are combined to provide the effects of long-acting high moisturizing and fresh and non-greasy skin feeling.
Disclosure of Invention
In view of the above, the present invention develops a long-lasting high moisture retention supramolecular fat emulsion glycerol glucoside composition.
The invention aims to overcome the defects and shortcomings of the prior art and provide a supermolecular fat milk glycerol glucoside composition with long-acting and high moisturizing performance.
Another object of the present invention is to provide a method for preparing the supramolecular fat milk glycerol glucoside composition with long-acting and high moisture retention.
Still another object of the present invention is to provide the use of the supramolecular fat milk glycerol glucoside composition with long-acting and high moisturizing effect.
In a first aspect, the application discloses a supermolecule fat milk glycerol glucoside composition with long-acting and high moisture retention, which comprises the following components in parts by mass: 1-30 parts of oily functional components, 0.1-8 parts of soybean lecithin, 0.1-8 parts of PEG-40 hydrogenated castor oil, 3-5 parts of pentanediol, 0.01-2 parts of tocopherol acetate, 0.01-2 parts of sodium oleate, 0.01-2 parts of EDTA-2Na0.01-2 parts of glycerol glucoside and 30-80 parts of water.
The dosage of the water is preferably 68.9 parts, the oily functional component is preferably hydrogenated isobutene 20 parts, soybean lecithin 1 part, PEG-40 hydrogenated castor oil 5 parts, pentanediol 3 parts, tocopherol acetate 0.5 part, sodium oleate 0.5 part, EDTA-2Na0.1 part and glycerol glucoside 2 parts.
The oily functional component can be any one or more of hydrogenated isobutene, olive oil, grape seed oil, caprylic/capric triglyceride, isooctyl palmitate, jojoba oil, shea butter, sunflower oil, sweet almond oil, tea seed oil, wheat germ oil and avocado oil.
The glycerol glucoside is Shine + glycerol glucoside, is colorless or yellowish viscous liquid prepared from glycerol glucoside, pentanediol and water, and has slight characteristic odor. It is easy to dissolve in water, methanol and ethanol, and can maintain high surface activity in high concentration sodium hydroxide and sodium silicate solution. The pH value of the pure product is 4.0-7.0, wherein the 2-alpha GG content in the product is 40-50%.
The pentanediol is preferably 1, 2-pentanediol.
In a second aspect, the present application discloses a method for preparing the supramolecular fat milk glycerol glucoside composition with long-acting and high moisture retention, which comprises the following steps:
(1) mixing glycerol glucoside, EDTA-2Na, 1, 2-pentanediol and water in a beaker, heating to 50-70 ℃, and uniformly stirring;
(2) heating hydrogenated isobutene, soybean lecithin, PEG-40 hydrogenated castor oil, tocopherol acetate and sodium oleate to 50-70 ℃, and uniformly stirring;
(3) slowly adding the organic phase in the step (2) into the water phase in the step (1) under a shearing condition, and continuously shearing for 3-5 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) and (4) carrying out high-pressure homogenization treatment on the cut material body (3) to obtain the final product of the supermolecule fat milk glycerol glucoside composition with long-acting and high-moisture retention.
Wherein the temperature conditions for preparing the supermolecule fat milk glycerol glucoside composition solution with long-acting and high moisture retention are as follows: 40-80 ℃, preferably 55-65 ℃.
The stirring speed is 100-1000rpm, preferably 500-800 rpm.
The stirring time is 1-12 h.
The shearing conditions are as follows: 1000 to 9000rpm, preferably 3000 to 5000rpm, and a shearing time of 1 to 10 minutes, preferably 3 to 5 minutes.
The high-pressure homogenizer is preferably a two-step high-pressure homogenizer, and the homogenizing conditions are as follows: the homogeneous pressure of the primary valve is 400-1500bar, preferably 600-1000 bar; the secondary valve is between 0 and 200bar, preferably between 50 and 150 bar; homogenizing for 2-15 times, preferably 6-10 times; the homogenization temperature is 0-80 deg.C, preferably 40-60 deg.C.
In a third aspect, the application protects the application of the supermolecule fat milk glycerol glucoside composition with long-acting and high moisture retention in the preparation of cosmetics.
The dosage forms of the cosmetics comprise water aqua, emulsion, cream and other dosage forms.
The addition amount of the supermolecule fat milk glycerol glucoside composition with long-acting high moisture retention is preferably 1-50% (w/w).
The moisturizing skin care lotion with the long-acting high-moisturizing supermolecule fat milk glycerol glucoside composition comprises the following components in percentage by mass:
phase A: 57.7% of water, 5% of glycerol, 0.1% of allantoin, 0.3% of carbomer and 0.15% of xanthan gum;
phase B: 3% of 1, 3-butanediol, 3% of betaine and 0.05% of sodium hyaluronate;
and C phase: 20% of a long-acting high-moisture supermolecule fat emulsion glycerol glucoside composition, 0.2% of panthenol, 2% of a witch hazel extract, 5% of hydroxyethyl urea, 0.2% of triethanolamine, 2% of an aloe extract and 0.5% of a tremella extract;
phase D: 0.1% of essence and 0.7% of preservative;
the preservative is preferably PE 9010.
The preparation method of the moisturizing skin care milk with the long-acting high-moisturizing supramolecular fat milk glycerol glucoside composition comprises the following steps:
(1) mixing the components in the phase A, stirring the mixture until the mixture is fully soaked, heating the mixture to 70-80 ℃, and homogenizing the mixture for 3-5 minutes under the homogenizing condition of 2000-3000 rpm to fully shear and uniformly mix the material body;
(2) cooling to about 60 deg.C, adding prepared phase B, stirring while heating, and maintaining the temperature for at least 15-20 min to obtain phase A + B;
(3) and (3) when the temperature is reduced to about 50 ℃, weighing the C-phase raw material, adding the C-phase raw material into the system, fully and uniformly stirring, adding the D-phase raw material when the temperature is reduced to normal temperature, uniformly stirring, and discharging.
The moisturizing essence with the long-acting high-moisturizing supermolecule fat emulsion glycerol glucoside composition comprises the following components in percentage by mass:
phase A: 53.94% of water, 3% of glycerol, 0.2% of allantoin, 0.3% of acrylic acid (ester)/C10-30% of alkanol acrylate cross-linked polymer and 0.05% of hydroxyethyl cellulose;
phase B: 4% of 1, 3-butanediol, 1% of sodium polyglutamate, 1.2% of arginine and 0.05% of sodium hyaluronate;
and C phase: 5% of a supermolecule fat milk glycerol glucoside composition with long-acting high moisture retention, 2% of a purslane extracting solution, 0.2% of panthenol, 5% of hydroxyethyl urea and 0.5% of a tremella extract;
phase D: 0.1 percent of essence and 0.25 percent of Jimabp;
the preparation method of the moisturizing essence with the long-acting high-moisturizing supramolecular fat emulsion glycerol glucoside composition comprises the following steps:
(1) mixing the components in the phase A, stirring the mixture until the mixture is fully soaked, heating the mixture to 70-80 ℃, and homogenizing the mixture for 3-5 minutes under the homogenization condition of 2000-3000 rpm to fully shear and uniformly mix the mixture;
(2) when the temperature is reduced to about 60 ℃, adding the prepared phase B, heating while stirring, and preserving the heat for at least 15-20 minutes to ensure that the material body is fully and uniformly stirred;
(3) and (3) when the temperature is reduced to about 50 ℃, weighing the C-phase raw material, adding the C-phase raw material into the system, fully and uniformly stirring, adding the D-phase raw material when the temperature is reduced to normal temperature, uniformly stirring, and discharging.
Compared with the prior art, the invention has the following advantages and effects: the different components in the supermolecule fat milk glycerol glucoside composition with long-acting and high moisturizing effects provided by the invention have synergistic effects, and the respective effects are improved. The oily component is wrapped by the liposome, so that the skin irritation is obviously reduced, the transdermal efficiency is effectively improved, the sustained-release effect is realized, the moisturizing duration is obviously prolonged, the phospholipid is similar to human skin, the effects of mildness and no irritation are realized, and the skin can be better protected. The glycerol glucoside prepared by the supermolecule biocatalysis technology has high content of 2-alpha GG, and the product has the advantages of less pollution, high optical purity and the like. Can promote the expression of skin aquaporin AQP3 and enhance the moisturizing capability of skin, compared with the traditional sodium hyaluronate, the moisturizing capability of the glycerol glucoside is equivalent to that of the traditional sodium hyaluronate, but the molecular weight of the glycerol glucoside is 5000 times less than that of HA, and the glycerol glucoside HAs the obvious advantages of fresh skin feel, strong moisturizing capability and the like when being applied to skin care products.
Drawings
FIG. 1: the trend chart of the moisture content of the horny layer of the long-acting high-moisturizing supramolecular fat emulsion glycerol glucoside composition, the supramolecular squalane fat emulsion, the sodium hyaluronate solution and the blank control group is provided by the embodiment 1 of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The following describes the implementation of the present invention in detail with reference to specific embodiments.
Working example 1
A preparation method of a supermolecule fat milk glycerol glucoside composition with long-acting and high moisture retention comprises the following steps:
(1) taking a beaker, mixing 2 parts of glycerol glucoside, 0.1 part of EDTA-2Na, 3 parts of 1, 2-pentanediol and 68.9 parts of water, heating to 70 ℃, and uniformly stirring at the rotating speed of 600 rpm;
(2) 20 parts of hydrogenated isobutylene, 1 part of soybean lecithin, 5 parts of PEG-40 hydrogenated castor oil, 0.5 part of tocopheryl acetate and 0.5 part of sodium oleate are weighed, heated to 70 ℃, and stirred uniformly at the rotating speed of 600 rpm.
(3) Keeping the temperature at about 65 ℃, preferably slowly adding the organic phase in the step (2) into the water phase in the step (1) under the condition of rotating speed shearing at 4000rpm, and continuously shearing for 3-5 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) and (3) carrying out high-pressure homogenization treatment on the sheared material body (3) for 6 times to obtain the final product of the supermolecule fat milk glycerol glucoside composition with long-acting and high moisture retention.
Working example 2
A preparation method of a long-acting and high-moisture-retention supermolecule fat milk glycerol glucoside composition comprises the following steps:
(1) mixing 2 parts of glycerol glucoside, 0.1 part of EDTA-2Na, 3 parts of 1, 2-pentanediol and 62.7 parts of water in a beaker, heating to 70 ℃, and uniformly stirring at the rotating speed of 600 rpm;
(2) heating 25 parts of caprylic/capric triglyceride, 1.2 parts of soybean lecithin, 6 parts of PEG-40 hydrogenated castor oil, 0.5 part of tocopheryl acetate and 0.5 part of sodium oleate to 70 ℃, and uniformly stirring at the rotating speed of 600 rpm.
(3) Keeping the temperature at about 65 ℃, preferably slowly adding the organic phase in the step (2) into the water phase in the step (1) under the condition of rotating speed shearing at 4000rpm, and continuously shearing for 3-5 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) and (3) carrying out high-pressure homogenization treatment on the sheared material body (3) for 6 times to obtain the final product of the supermolecule fat milk glycerol glucoside composition with long-acting and high moisture retention.
Embodiment example 3
A preparation method of a long-acting and high-moisture-retention supramolecular fat milk glycerol glucoside composition comprises the following steps:
(1) mixing 2 parts of glycerol glucoside, 0.1 part of EDTA-2Na, 3 parts of 1, 2-pentanediol and 56.4 parts of water in another beaker, heating to 70 ℃, and uniformly stirring at the rotating speed of 600 rpm;
(2) 30 parts of olive oil, 1.5 parts of soybean lecithin, 7 parts of PEG-40 hydrogenated castor oil, 0.5 part of tocopherol acetate and 0.5 part of sodium oleate are heated to 70 ℃ and stirred uniformly at the rotating speed of 600 rpm.
(3) Keeping the temperature at about 65 ℃, preferably slowly adding the organic phase in the step (2) into the water phase in the step (1) under the condition of rotating speed shearing at 4000rpm, and continuously shearing for 3-5 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) and (3) carrying out high-pressure homogenization treatment on the sheared material body (3) for 6 times to obtain the final product of the supermolecule fat milk glycerol glucoside composition with long-acting and high moisture retention.
Application embodiment example 1
Preparation of moisturizing skin care lotion with long-acting high-moisturizing supermolecule fat milk glycerol glucoside composition
(1) Weighing 5 parts of glycerol, 0.3 part of carbomer and 0.15 part of xanthan gum into a 200 ml beaker, premixing and stirring uniformly, adding 57.7 parts of water and 0.1 part of allantoin, stirring uniformly, heating to 70-80 ℃, homogenizing for 3-5 minutes under the homogenizing condition of 2000-3000 rpm, and fully shearing and uniformly mixing the materials;
(2) when the temperature of the system is reduced to about 60 ℃,3 parts of 1, 3-butanediol and 0.05 part of sodium hyaluronate are weighed, premixed and stirred uniformly, added into the system, stirred uniformly, 3 parts of betaine is weighed, added into the system, heated while stirring, and kept at 60 ℃ for at least 15-20 minutes;
(3) when the temperature is reduced to about 50 ℃, 20 parts of embodiment example 1, 0.2 part of panthenol, 2 parts of witch hazel extract, 5 parts of hydroxyethyl urea, 0.2 part of triethanolamine, 2 parts of aloe extract and 0.5 part of tremella extract are weighed and added into the system, the mixture is uniformly stirred, when the temperature of the system is reduced to the normal temperature, 0.1 part of essence and 0.7 part of PE9010 are added, the mixture is stirred for 10-30 minutes until the material body is uniform, and the mixture is discharged.
Application implementation example 2
Preparation of moisturizing essence with long-acting high-moisturizing supramolecular fat emulsion glycerol glucoside composition
(1) Weighing 3 parts of glycerol, 0.3 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 0.05 part of hydroxyethyl cellulose into a 200 ml beaker, premixing and stirring uniformly, adding 53.94 parts of water and 0.2 part of allantoin, stirring uniformly, heating to 70-80 ℃, homogenizing at 2000-3000 rpm for 3-5 minutes to fully shear and uniformly mix the material;
(2) when the temperature of the system is reduced to about 60 ℃, weighing 4 parts of 1, 3-butanediol and 0.05 part of sodium hyaluronate, premixing uniformly, adding into the system, stirring uniformly, weighing 1 part of sodium polyglutamate and 1.2 parts of arginine, adding into the system, heating while stirring, and preserving heat at 60 ℃ for at least 15-20 minutes;
(3) when the temperature is reduced to about 50 ℃, 5 parts of embodiment example 2, 0.2 part of panthenol, 2 parts of purslane extract, 5 parts of hydroxyethyl urea and 0.5 part of tremella extract are weighed and added into the system, the mixture is uniformly stirred, when the temperature of the system is reduced to normal temperature, 0.1 part of essence and 0.25 part of germa BP are added, the mixture is stirred for 10-30 minutes until the material body is uniform, and the material is discharged.
Table 1: implementing example physicochemical inspection data results
| Detecting items | Working example 1 | Example of |
Embodiment example 3 | Application embodiment example 1 | Application embodiment example 2 |
| Sensory testing | No abnormality | No abnormality | No abnormality | No abnormality | No abnormality |
| Heat resistance test | Stabilization | Stabilization | Stabilization | Stabilization | Stabilization |
| Cold resistance test | Stabilization of | Stabilization | Stabilization | Stabilization | Stabilization |
| Centrifugal experiment | Stabilization | Stabilization of | Stabilization | Stabilization | Stabilization |
Note: physical and chemical tests are carried out according to the execution standard requirements of national standard GB/T29665 and QB/T2660 skin care emulsion and skin care water, and the results show that the implementation examples are all in a stable state.
Table 2: results of particle size potential measurements of the example products 1-3
| Sample (I) | Particle size (nm) | Electric potential (mV) |
| Working example 1 | 160 | -29.3 |
| Working example 2 | 158 | -33.2 |
| Embodiment example 3 | 162 | -27.1 |
Different components in the supermolecule fat milk glycerol glucoside composition with long-acting and high moisture retention have synergistic effect, and respective effects of the components are improved. The oily components are wrapped by the liposome, so that the skin irritation is obviously relieved, the transdermal efficiency is effectively improved, the sustained-release effect is achieved, the moisturizing duration is obviously prolonged, the phospholipid is similar to human skin, the skin moisturizing composition has the mild and non-irritating effects, and the skin can be better protected. The glycerol glucoside prepared by the supermolecule biocatalysis technology has high content of 2-alpha GG, and the product has the advantages of less pollution, high optical purity and the like. Can promote the expression of skin aquaporin AQP3 and enhance the moisturizing capability of skin, compared with the traditional sodium hyaluronate, the moisturizing capability of the glycerol glucoside is equivalent to that of the traditional sodium hyaluronate, but the molecular weight of the glycerol glucoside is 5000 times less than that of HA, and the glycerol glucoside HAs the obvious advantages of fresh skin feel, strong moisturizing capability and the like when being applied to skin care products.
The supermolecule chemistry is based on the chemistry of molecules formed by two or more than two molecules through non-covalent bond interaction between the molecules, three chemists of Nobel prize-earher C.J Pedersen (Pedersen), J.M Lehn (Laine) and D.J Cram (gram) in 1987 make pioneer work on the aspect of supermolecule chemical theory, French scientist J.M.Lehn firstly puts forward the concept of supermolecule chemistry and opens up a brand-new direction for the development of the future chemistry. At present, a supermolecule technology is widely applied to the cosmetic industry, and raw materials are extracted, refined, wrapped and synthesized through the supermolecule technology, so that the permeability promotion of the raw materials in a formula can be improved, the transdermal absorption rate of active ingredients and the action time of the active ingredients can be improved, and the like.
The supermolecule fat emulsion consists of an oil phase, an emulsifier, an auxiliary emulsifier and a water phase, and the particle size is 10-300 nm. Is suitable for being applied to formulas of cosmetic skin lotion, essence, emulsion, cream and the like. Active ingredients are wrapped in a designed delivery vehicle, the supermolecule nano wrapping promotes the transdermal absorption of the active ingredients, the active ingredients are delivered to the effective parts, the stability of the active ingredients is improved, the irritation and the toxic and side effects of the active ingredients are reduced, and the moisture retention performance and the duration of the raw materials can be effectively enhanced.
The glycerol glucoside is a glucoside compound formed by connecting a molecule of glycerol and a molecule of glucose through a glycosidic bond, aiming at the defects of the traditional biocatalysis technology, the glycerol glucoside prepared by adopting the supermolecule biocatalysis technology has high content of 2-alpha GG, and the product has the advantages of less pollution, high optical purity and the like. The glycerol glucoside has excellent moisturizing capability, and documents prove that the 2-alpha configuration glycerol glucoside can obviously improve the expression of aquaporin AQP3, and the AQP3 protein plays an important role in the moisturizing function of skin epithelial cells. Meanwhile, researches prove that the glycerol glucoside has good skin permeability and can effectively reduce water loss. In addition, 2- α GG has a variety of physiological activities, such as activating and promoting cell regeneration; enhancing cell activity and accelerating cell metabolism; enhancing the antioxidant capacity of cells; the collagen synthesis is promoted, the molecular weight of the collagen is 5000 times smaller than that of HA, and the collagen HAs the obvious advantages of fresh skin feel, strong moisturizing capability and the like when being applied to skin care products.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those skilled in the art; the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; these modifications and substitutions do not cause the essence of the corresponding technical solution to depart from the scope of the technical solution of the embodiments of the present invention, and are intended to be covered by the claims and the specification of the present invention.
Claims (10)
1. The long-acting high-moisture-retention supramolecular fat milk glycerol glucoside composition is characterized by comprising the following components in parts by mass: 1-30 parts of oily functional components, 0.1-8 parts of soybean lecithin, 0.1-8 parts of PEG-40 hydrogenated castor oil, 3-5 parts of pentanediol, 0.01-2 parts of tocopherol acetate, 0.01-2 parts of sodium oleate, 0.01-2 parts of EDTA-2Na0.01-2 parts of glycerol glucoside and 30-80 parts of water.
2. The long-acting high-moisturizing supramolecular fat milk glycerol glucoside composition as claimed in claim 1, wherein the oily efficacy ingredient comprises one or more of hydrogenated isobutylene, olive oil, grape seed oil, caprylic/capric triglyceride, isooctyl palmitate, jojoba oil, shea butter, sunflower oil, sweet almond oil, tea seed oil, wheat germ oil, avocado oil.
3. The long-acting high-moisturizing supramolecular fat emulsion glycerol glucoside composition of claim 1, wherein said pentanediol is 1, 2-pentanediol.
4. A preparation method of a long-acting high-moisture-retention supramolecular fat milk glycerol glucoside composition is characterized by comprising the following steps:
(1) mixing EDTA-2Na, glycerol glucoside, 1, 2-pentanediol and water in a beaker, heating to 50-70 ℃, and uniformly stirring;
(2) heating hydrogenated isobutene, soybean lecithin, PEG-40 hydrogenated castor oil, tocopherol acetate and sodium oleate to 50-70 deg.C, and stirring;
(3) slowly adding the organic phase in the step (2) into the water phase in the step (1) under a shearing condition, and continuously shearing for 3-5 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) and (3) carrying out high-pressure homogenization treatment on the sheared material body to obtain the final product of the supermolecule fat milk glycerol glucoside composition with long-acting and high moisture retention.
5. Use of the long-acting high moisture supramolecular fat milk glycerol glucoside composition as claimed in any one of claims 1-3 for the preparation of cosmetics.
6. The use according to claim 5, wherein the long-acting high-moisture-retention supramolecular fat emulsion glycerol glucosidation composition is added in an amount of 1-50% (w/w).
7. The use according to claim 5, wherein the cosmetic is a moisturizing skin care lotion supplemented with a long-acting high-moisturizing supramolecular fat milk glycerol glucoside composition.
8. The long-acting high-moisturizing supermolecule fat milk glycerol glucoside composition moisturizing skin-care milk is characterized by comprising the following components in percentage by mass:
phase A: 57.7% of water, 5% of glycerol, 0.1% of allantoin, 0.3% of carbomer and 0.15% of xanthan gum;
phase B: 3% of 1, 3-butanediol, 3% of betaine and 0.05% of sodium hyaluronate;
and C phase: example 1 composition 20%, panthenol 0.2%, witch hazel extract 2%, hydroxyethyl urea 5%, triethanolamine 0.2%, aloe extract 2%, and Tremella extract 0.5%;
phase D: 0.1 percent of essence and 0.7 percent of preservative.
9. The use of claim 5, wherein the cosmetic is a long-acting high-moisturizing supramolecular fat emulsion glycerol glucoside composition moisturizing essence.
10. The long-acting high-moisturizing supermolecule fat emulsion glycerol glucoside composition moisturizing essence is characterized by comprising the following components in percentage by mass:
phase A: 53.94% of water, 3% of glycerol, 0.2% of allantoin, 0.3% of acrylic acid (ester)/C10-30% of alkanol acrylate cross-linked polymer and 0.05% of hydroxyethyl cellulose;
phase B: 4% of 1, 3-butanediol, 1% of sodium polyglutamate, 1.2% of arginine and 0.05% of sodium hyaluronate;
and C phase: example 2 composition 5%, purslane extract 2%, panthenol 0.2%, hydroxyethyl urea 5%, tremella extract 0.5%;
phase D: 0.1 percent of essence and 0.25 percent of German BP.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115400046A (en) * | 2022-08-31 | 2022-11-29 | 深圳市萱嘉生物科技有限公司 | Preparation method and application of supramolecular liposome cream |
| CN115918897A (en) * | 2022-10-10 | 2023-04-07 | 青岛中科蓝智生物科技发展有限公司 | Glycerol glucoside product and antioxidant application thereof in food field |
| CN115778867A (en) * | 2022-12-29 | 2023-03-14 | 北京理工大学重庆创新中心 | Compound humectant, supramolecular liposome moisturizing emulsion with compound humectant and preparation method of supramolecular liposome moisturizing emulsion |
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