CN115518191A - 一种可以促进伤口快速止血的医用敷料的制备方法 - Google Patents
一种可以促进伤口快速止血的医用敷料的制备方法 Download PDFInfo
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Abstract
本发明公开了一种可以促进伤口快速止血的医用敷料的制备方法，包括以下步骤：将明胶在40‑60℃温度下将其溶解于去离子水，配制成明胶溶液；在明胶溶液中加入改性富勒烯衍生物，分散均匀，添加抗菌成分混合液，然后倒入模具中，常温下静置并排出气泡，然后放入零下40℃‑零下25℃的低温下预冻，然后在真空冷冻干燥机中冷冻干燥，得到混合干凝胶，将混合干凝胶从模具中取出，并在上下两面分别覆盖一层医用纱布，紧密贴合后，即为可以促进伤口快速止血的医用敷料。该医用敷料可以对各种出血情况及时止血，一般止血所需时间低于5分钟。
Description
技术领域
本发明涉及止血的外用敷料技术领域，尤其涉及一种可以促进伤口快速止血的医用敷料的制备方法。
背景技术
战争、野外活动以及手术等所引起的血管破裂，会使伤者产生疼痛、昏迷、甚至死亡，由此给患者的生命健康造成了极大的威胁。快速止血的目的在于给伤者赢得救治时间以及获得良好的预后，仅依靠机体自身的生理性止血还远远达不到该目的，因此引入外源性物质对伤口进行止血就显得尤为重要。
然而传统的止血方式止血速度仍需要提升以满足现实的需要，敷料中含有的不易降解物质进入血管容易造成血栓，且传统敷料易与新生肉芽组织产生粘连，进而影响伤口愈合并给患者带来了二次伤害。
但是在现实情况下，大动脉、大静脉破裂所引起的大出血的止血非常难，而现有的止血材料的止血效果均有待提高，故有必要研究一种可以促进伤口快速止血的医用敷料。
发明内容
基于背景技术存在的技术问题，本发明提出了一种可以促进伤口快速止血的医用敷料的制备方法。
本发明的技术方案如下：
一种可以促进伤口快速止血的医用敷料的制备方法，包括以下步骤：
(1)将明胶在40-60℃温度下将其溶解于去离子水，配制成质量浓度为15-25％的明胶溶液；
(2)在明胶溶液中加入改性富勒烯衍生物，300-400rpm磁力搅拌20-30min，得到混合溶液；
(3)在混合溶液中添加抗菌成分混合液，然后倒入模具中，液层厚度5-8mm，常温下静置45-60min并排出气泡，然后放入零下40℃-零下25℃的低温下预冻1-1.5h，然后在真空冷冻干燥机中冷冻干燥，得到混合干凝胶；
(4)将混合干凝胶从模具中取出，并在上下两面分别覆盖一层医用纱布，紧密贴合后，即为可以促进伤口快速止血的医用敷料。
所述的改性富勒烯衍生物的制备方法参考中国发明专利CN110183718A的实施例1。
优选的，所述的步骤(2)中，所述的改性富勒烯衍生物的添加量为明胶溶液质量的0.02-0.05％。
优选的，所述的步骤(2)中，所述的改性富勒烯衍生物的分子式为：
优选的，所述的步骤(3)中，所述的抗菌成分混合液的添加量为明胶溶液质量的1.8-3.5％。
进一步优选的，所述的抗菌成分混合液，由以下重量百分比的成分组成：凡士林2-5％、十二烷基硫酸钠1-3％、半合成脂肪酸甘油酯3-6％、羧甲基壳聚糖1.5-2.8％、甘油1.8-2.5％、硝酸银0.05-0.1％和去离子水余量。
本发明的有益之处在于：本发明的可以促进伤口快速止血的医用敷料，包括以下步骤：将明胶在40-60℃温度下将其溶解于去离子水，配制成明胶溶液；在明胶溶液中加入改性富勒烯衍生物，分散均匀，添加抗菌成分混合液，然后倒入模具中，常温下静置并排出气泡，然后放入零下40℃-零下25℃的低温下预冻，然后在真空冷冻干燥机中冷冻干燥，得到混合干凝胶，将混合干凝胶从模具中取出，并在上下两面分别覆盖一层医用纱布，紧密贴合后，即为可以促进伤口快速止血的医用敷料。其中，抗菌成分混合液，由以下重量百分比的成分组成：凡士林2-5％、十二烷基硫酸钠1-3％、半合成脂肪酸甘油酯3-6％、羧甲基壳聚糖1.5-2.8％、甘油1.8-2.5％、硝酸银0.05-0.1％和去离子水余量。该医用敷料可以对各种出血情况及时止血，一般止血所需时间低于5分钟。本发明的医用敷料中加入改性富勒烯衍生物后，可以显著提升药效。
具体实施方式
实施例1
一种可以促进伤口快速止血的医用敷料的制备方法，包括以下步骤：
(1)将明胶在48℃温度下将其溶解于去离子水，配制成质量浓度为22％的明胶溶液；
(2)在明胶溶液中加入改性富勒烯衍生物，360pm磁力搅拌25min，得到混合溶液；
(3)在混合溶液中添加抗菌成分混合液，然后倒入模具中，液层厚度6mm，常温下静置50min并排出气泡，然后放入零下27℃的低温下预冻1.3h，然后在真空冷冻干燥机中冷冻干燥，得到混合干凝胶；
(4)将混合干凝胶从模具中取出，并在上下两面分别覆盖一层4mm医用纱布，紧密贴合后，即为可以促进伤口快速止血的医用敷料。
所述的步骤(2)中，改性富勒烯衍生物的添加量为明胶溶液质量的0.03％。
所述的步骤(2)中，所述的改性富勒烯衍生物的分子式为：
所述的步骤(3)中，所述的抗菌成分混合液的添加量为明胶溶液质量的2.5％。
所述的抗菌成分混合液，由以下重量百分比的成分组成：凡士林3.5％、十二烷基硫酸钠1.8％、半合成脂肪酸甘油酯4.2％、羧甲基壳聚糖1.8％、甘油2.2％、硝酸银0.08％和去离子水余量。
实施例2
一种可以促进伤口快速止血的医用敷料的制备方法，包括以下步骤：
(1)将明胶在60℃温度下将其溶解于去离子水，配制成质量浓度为15％的明胶溶液；
(2)在明胶溶液中加入改性富勒烯衍生物，400rpm磁力搅拌20min，得到混合溶液；
(3)在混合溶液中添加抗菌成分混合液，然后倒入模具中，液层厚度8mm，常温下静置45min并排出气泡，然后放入零下40℃的低温下预冻1h，然后在真空冷冻干燥机中冷冻干燥，得到混合干凝胶；
(4)将混合干凝胶从模具中取出，并在上下两面分别覆盖一层4mm医用纱布，紧密贴合后，即为可以促进伤口快速止血的医用敷料。
所述的步骤(2)中，改性富勒烯衍生物的添加量为明胶溶液质量的0.05％。
所述的步骤(2)中，所述的改性富勒烯衍生物的分子式为：
所述的步骤(3)中，所述的抗菌成分混合液的添加量为明胶溶液质量的3.5％。
所述的抗菌成分混合液，由以下重量百分比的成分组成：凡士林5％、十二烷基硫酸钠1％、半合成脂肪酸甘油酯6％、羧甲基壳聚糖1.5％、甘油2.5％、硝酸银0.05％和去离子水余量。
实施例3
一种可以促进伤口快速止血的医用敷料的制备方法，包括以下步骤：
(1)将明胶在40℃温度下将其溶解于去离子水，配制成质量浓度为25％的明胶溶液；
(2)在明胶溶液中加入改性富勒烯衍生物，300rpm磁力搅拌30min，得到混合溶液；
(3)在混合溶液中添加抗菌成分混合液，然后倒入模具中，液层厚度5mm，常温下静置60min并排出气泡，然后放入零下25℃的低温下预冻1.5h，然后在真空冷冻干燥机中冷冻干燥，得到混合干凝胶；
(4)将混合干凝胶从模具中取出，并在上下两面分别覆盖一层5mm医用纱布，紧密贴合后，即为可以促进伤口快速止血的医用敷料。
所述的步骤(2)中，改性富勒烯衍生物的添加量为明胶溶液质量的0.02％。
所述的步骤(2)中，所述的改性富勒烯衍生物的分子式为：
所述的步骤(3)中，所述的抗菌成分混合液的添加量为明胶溶液质量的1.8％。
所述的抗菌成分混合液，由以下重量百分比的成分组成：凡士林2％、十二烷基硫酸钠3％、半合成脂肪酸甘油酯3％、羧甲基壳聚糖2.8％、甘油1.8％、硝酸银0.1％和去离子水余量。
对比例1
将抗菌成分混合液中的羧甲基壳聚糖去除，其余配比和制备方法与实施例1相同。
对比例2
将抗菌成分混合液中的羧甲基壳聚糖替换为未改性的壳聚糖，其余配比和制备方法与实施例1相同。
对比例3
将抗菌成分混合液中的改性富勒烯衍生物去除，其余配比和制备方法与实施例1相同。
对比例4
将抗菌成分混合液中的改性富勒烯衍生物替换为未改性的富勒烯C60，其余配比和制备方法与实施例1相同。
对比例5
将抗菌成分混合液中的改性富勒烯衍生物替换为三维多孔双交联聚苯胺/石墨烯复合干凝胶，其余配比和制备方法与实施例1相同。
对比例6
采用CN202111024818.3实施例1制备的外伤急救止血材料进行对比测试。
测试例
以下对实施例1-3和对比例1-6的医用敷料应用于猪股动脉止血，并从3分钟开始每隔1分钟检测创口愈合时间(创口愈合时间只统计20分钟内创口愈合的猪的创口愈合时间，未愈合的猪不统计在内)，具体方法如下：每个实施例分别选取50个100±2kg的长白猪(公母比例约为1:1，各实施例之间无明显差异)；用薄刀片造成长度为3±0.2cm的股动脉切口；立即使用医用敷料贴合创口并进行指压。采用云南白药+厚纱布并进行指压作为对照例；具体检测数据见表1。
表1：应用于猪股动脉，止血效果对比检测数据；
| 猪总数量 | 创口愈合数 | 创口愈合时间(min) | |
| 实施例1 | 50 | 50 | 2.6 |
| 实施例2 | 50 | 50 | 2.8 |
| 实施例3 | 50 | 50 | 2.9 |
| 对比例1 | 50 | 47 | 5.7 |
| 对比例2 | 50 | 48 | 5.6 |
| 对比例3 | 50 | 41 | 9.3 |
| 对比例4 | 50 | 45 | 8.2 |
| 对比例5 | 50 | 48 | 7.5 |
| 对比例6 | 50 | 50 | 5.1 |
| 对照例 | 50 | 47 | 10.8 |
备注：创口愈合指不压迫创口情况下，10s内不渗血。
由以上测试数据可以知道，本发明的医用敷料，应用于止血，可以显著缩短创口愈合时间，并且本发明中同时加入改性富勒烯衍生物和羧甲基壳聚糖具有协同效果。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (5)
1.一种可以促进伤口快速止血的医用敷料的制备方法，其特征在于，包括以下步骤：
(1)将明胶在40-60℃温度下将其溶解于去离子水，配制成质量浓度为15-25％的明胶溶液；
(2)在明胶溶液中加入改性富勒烯衍生物，300-400rpm磁力搅拌20-30min，得到混合溶液；
(3)在混合溶液中添加抗菌成分混合液，然后倒入模具中，液层厚度5-8mm，常温下静置45-60min并排出气泡，然后放入零下40℃-零下25℃的低温下预冻1-1.5h，然后在真空冷冻干燥机中冷冻干燥，得到混合干凝胶；
(4)将混合干凝胶从模具中取出，并在上下两面分别覆盖一层医用纱布，紧密贴合后，即为可以促进伤口快速止血的医用敷料。
2.如权利要求1所述的可以促进伤口快速止血的医用敷料的制备方法，其特征在于，所述的步骤(2)中，所述的改性富勒烯衍生物的添加量为明胶溶液质量的0.02-0.05％。
3.如权利要求1所述的可以促进伤口快速止血的医用敷料的制备方法，其特征在于，所述的步骤(2)中，所述的改性富勒烯衍生物的分子式为：
4.如权利要求1所述的可以促进伤口快速止血的医用敷料的制备方法，其特征在于，所述的步骤(3)中，所述的抗菌成分混合液的添加量为明胶溶液质量的1.8-3.5％。
5.如权利要求1所述的可以促进伤口快速止血的医用敷料的制备方法，其特征在于，所述的抗菌成分混合液，由以下重量百分比的成分组成：凡士林2-5％、十二烷基硫酸钠1-3％、半合成脂肪酸甘油酯3-6％、羧甲基壳聚糖1.5-2.8％、甘油1.8-2.5％、硝酸银0.05-0.1％和去离子水余量。
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