CN115397463A - 抗非洲猪瘟病毒感染的疫苗 - Google Patents
抗非洲猪瘟病毒感染的疫苗 Download PDFInfo
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- CN115397463A CN115397463A CN202180019234.9A CN202180019234A CN115397463A CN 115397463 A CN115397463 A CN 115397463A CN 202180019234 A CN202180019234 A CN 202180019234A CN 115397463 A CN115397463 A CN 115397463A
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Abstract
本发明涉及减毒非洲猪瘟病毒。减毒病毒保护猪免受随后的强毒病毒攻击。本发明还涉及使用这种减毒病毒治疗和/或预防非洲猪瘟。
Description
技术领域
本发明涉及减毒非洲猪瘟病毒。减毒病毒保护猪免受随后的强毒病毒攻击。本发明还涉及这种减毒病毒用于治疗和/或预防非洲猪瘟的用途。
发明背景
非洲猪瘟(ASF)
非洲猪瘟是由双链DNA病毒非洲猪瘟病毒(ASFV)引起的毁灭性家猪出血性疾病。ASFV是非洲猪瘟病毒科(Asfarviridae)的唯一成员，主要在细胞的细胞质中复制。ASFV的强毒株可在感染后约5-14天内杀死家猪，死亡率接近100％。
ASFV可以在疣猪(Phacochoerus sp.)、丛林猪(Potamocherus sp.)和饨缘蜱属(Ornithodoros)的软蜱(其被认为是载体)中感染和复制，但在这些物种中几乎没有观察到任何临床症状(如果有的话)并且可以确定长期的持续感染。ASFV是在欧洲定居者将猪带入ASFV流行地区后首次描述的，因此是“新发感染”的实例。该病目前在许多撒哈拉以南的国家和欧洲撒丁岛流行。自2007年在跨高加索地区传入格鲁吉亚后，ASFV已在包括俄罗斯联邦在内的邻国广泛传播。2012年乌克兰首次爆发疫情，2013年白俄罗斯首次爆发疫情。2014年，在乌克兰的猪中报道了进一步的爆发并且在立陶宛和波兰的野猪中也检测到病毒。
目前没有ASF的治疗方法。非洲以外的国家已经尝试在国家层面上通过限制进口猪和猪肉产品、在饲喂猪前强制煮沸获得许可的废弃动物产品以及在诊断出疾病时实施屠宰政策等方式进行预防。非洲的预防基于使疣猪和被疣猪污染的材料远离猪群的措施。
因此，需要改进措施来控制ASFV感染并防止疾病传播。
非洲猪瘟病毒(ASFV)
已经比较了ASFV分离株贝宁97/1(来自西非的高致病性病毒，第1组)、分离株OURT88/3(来自葡萄牙的非致病性减毒病毒，第1组)和分离株BA71V(Vero细胞组织培养适应非致病性病毒，第1组)的全基因组序列(Chapman等人2008J.Gen Virol.89:397-408)。
在OURT88/3基因组中，五个MGF 360基因(10L、11L、12L、13L和14L)和两个MGF 505基因(1R、2R)缺失，MGF 505R 3R基因被截短。这些基因存在于已测序的所有其他八种ASFV病原分离株的基因组中。Chapman等人(如上)未确定导致OURT88/3减毒的任何突变。此外，尽管OURT88/3已显示在某些动物中诱导保护性免疫应答，但这种作用似乎并不普遍。用OURT88/3免疫似乎不能有效地保护一些猪免受随后的攻击。其还与一些猪的不良免疫反应如关节肿胀的诱导有关。
在适应于减毒组织培养的BA71V分离株中，基因组包含MGF 505 3R基因但缺少其他七个MGF基因，此外MGF 360 9L基因被截短。
先前的六个MGF 360基因(9L、10L、11L、12L、13L和14L)和两个MGF 505基因(1R和2R)从高致病性南非分离株Pr4中缺失。这种缺失显著降低了原代巨噬细胞培养物中的病毒生长(Zsak等人2001，如上)并导致病毒减毒(引用为未发表的结果，Afonso等人2004J.Virol 78:1858-1864)。然而，没有进行实验来攻击恢复的猪以确定它们是否受到保护。事实上，在2011年5月堪萨斯州曼哈顿生物安全研究所的非洲猪瘟病毒研讨会上，提及了Pr4缺失突变体没有保护作用并会诱发疾病的慢性形式。
还表明，三个MGF 360基因(12L、13L和14L)和四个MGF 505基因(1R、2R、3R和4R截短)从病原性病毒马拉维ΔDP71中的缺失会减少病毒在猪中的复制，此外还会使病毒减毒(Neilan等人(2002)J.Virol.76:3095-3104)。然而，同样没有报告任何实验来确定恢复的猪是否受到保护免受攻击。
缺失MGF505-1R、-2R和-3R以及MGF360-12L、-13L和-14L产生了赋予对亲本病毒的保护作用的减毒病毒(O'Donnell等人2015 J.Virol.89:6048-6056)。然而，仅MGF360-13L和-14L的缺失不会产生病毒减毒(Borca等人2017 Sci Rep.7:46747)。
区分感染和免疫动物(DIVA)疫苗
DIVA疫苗允许区分已经感染野生型病原体的动物与已经用疫苗免疫的动物。DIVA疫苗缺少至少一种存在于野生型病原体中的免疫原性抗原(DIVA标记物)。感染野生型病原体的动物会产生针对DIVA标记物的抗体，而接种疫苗的动物则不会。可以使用血清学测定来检测针对DIVA标记物的抗体。尽管两组动物都具有针对病原体的其他免疫原的抗体，但感染的动物(具有针对DIVA标记物的抗体)可以与免疫接种的动物(不具有针对DIVA标记物的抗体)区分开来。
DIVA标记物应当具有免疫原性，但基因的缺失不应影响疫苗的保护能力。
发明概述
在一个方面，本发明涉及减毒非洲猪瘟病毒，其中特定多基因家族(MGF)基因的表达和/或活性被破坏，而其他特定MGF基因的表达和/或活性未被破坏。
本发明还涉及以下发现：非洲猪瘟病毒的K145R和B125R基因可用作DIVA标记物。
本发明提供了减毒非洲猪瘟(ASF)病毒，其中以下基因的表达和/或活性被破坏：
多基因家族(MGF)360 12L、13L和14L，以及
MGF 505 1R，
并且该减毒ASF病毒包含以下基因的功能形式：
(i)MGF 360 10L和/或11L，以及
(ii)MGF 505 2R和/或3R。
本发明还提供了缺乏K145R基因和/或B125R基因的功能形式的减毒ASF病毒。
本发明还提供了包含根据本发明的减毒ASF病毒的疫苗。
本发明进一步提供了用于治疗和/或预防受试者的非洲猪瘟的本发明的疫苗。
本发明进一步提供了治疗和/或预防受试者的非洲猪瘟的方法，该方法包括向受试者施用有效量的根据本发明的疫苗的步骤。
本发明还提供了使ASF病毒减毒的方法，该方法包括破坏以下基因的活性和/或表达：
MGF 360 12L、13L和14L，以及
MGF 505 1R，
同时保留以下基因的功能的步骤：
(i)MGF 360 10L和/或11L，以及
(ii)MGF 505 2R和/或3R。
附图说明
图1显示了用与IRF3可激活启动子(A)、NF-κB可激活启动子(B)或GAL4可激活启动子(C、D)连接的萤光素酶报告基因转染并表达指定MGF基因的HEK293T细胞中的萤光素酶表达。启动子的表达通过仙台病毒刺激(A)、NF-κB p65转染(B)或IRF3-GAL4DBD嵌合体转染(C)或p65-GAL4DBD嵌合体转染(D)来激活。MGF基因抑制萤光素酶表达(即IRF3和NF-κB活性)(A、B)，MGF360-12L特别特异性抑制IRF3和NF-κB激活转录的能力(C、D)。
图2是MGFA和MGFB缺失的示意图。在每个基因名称下方，总结了IRF3和NF-κB依赖性萤光素酶报告基因的抑制信息，并列出了任何已确定的宿主靶标。
图3描述了用格鲁吉亚ΔK145RΔMGFA(C组)、格鲁吉亚ΔK145RΔMGFB(D组)和格鲁吉亚ΔB125RΔMGFA(BA组)病毒对猪进行免疫、加强和攻击的实验方案。
图4显示了D、C和BA组中的猪在免疫和攻击后的存活率。
图5显示了C组(A)、BA组(B)、D组(C)和对照F组(D)的猪在免疫和攻击后的温度。
图6显示了C组(A)、BA组(B)、D组(C)和对照F组(D)的猪在免疫和攻击后的临床评分。
图7显示C组(A)、BA组(B)、D组(C)和对照F组(D)的猪在免疫和攻击后在通过定量PCR测量的全血中病毒基因组(病毒血症)的水平。
图8显示了攻击后全血中感染性病毒的水平。
图9显示了C组(A、B)和BA组(C、D)的猪在免疫前、加强前和攻击前的T细胞反应。在免疫前、加强前和攻击前收集外周血单核细胞(PBMC)，并用同源强毒格鲁吉亚2007/1毒株(A、C)或异源基因型I强毒毒株贝宁97/1(B、D)的活ASFV刺激。通过Elispot测定法测量产生干扰素γ的细胞的数量。
图10显示了在C组(A)和BA组(B)的猪中使用商业竞争性ELISA(Ingenasa)在免疫后测量的对主要ASFV衣壳蛋白p72/B646L的抗体反应。
图11显示了用表达与HA表位标签融合的B125R基因的质粒转染的Vero细胞。将细胞固定并透化，然后用抗HA抗体染色，然后用适当的二抗染色。以绿色显示的B125R蛋白定位于细胞表面。细胞核以蓝色显示。
发明详述
非洲猪瘟病毒(ASFV)
非洲猪瘟病毒(ASFV)是非洲猪瘟(ASF)的病原体。ASFV的基因组结构是本领域已知的，详见Chapman等人2008 J.Gen.Virol.89:397-408。ASFV是大型、二十面体、双链DNA病毒，其具有含有至少150个基因的线性基因组。基因的数量在病毒的不同分离株之间略有不同。ASFV与其他大型DNA病毒，例如痘病毒、虹彩病毒和拟态病毒有相似之处。与其他病毒性出血热一样，其复制的主要靶细胞是单核细胞、巨噬细胞谱系细胞。
基于编码主要衣壳蛋白p72的B646L基因C端区域的序列变异，已鉴定出22种ASFV基因型(I-XXII)。所有ASFV P72基因型都在东部和南部非洲流行。基因型I已在欧洲、南美、加勒比和西非流行。基因型VIII被限制在四个东非国家。
以下给出来自一些基因型的毒株的实例。
基因型I:OURT88/3；巴西/79；里斯本/60；BA715；Pret；贝宁97/1；IC/1/96；IC/576；CAM/82；马德里/62；马耳他/78；ZAR85；Katange63；多哥；达喀尔59；Ourt88/1；BEN/1/97；Dom_Rep；VAL/76；IC/2/96；Awoshie/99；NIG/1/99；NIG/1/98；ANG/70；BEL/85；SPEC120；里斯本/57；ASFV-Warm；GHA/1/00；GAM/1/00；加纳；HOL/86；NAM/1/80；NUR/90/1；CAM/4/85；ASFV-Teng；Tegani；ASFV-E75。
基因型II：格鲁吉亚2007/1；POL/2015/波德拉谢(波兰毒株)；比利时/Etalle/wb/2018；ASFV/基辅/2016/131；中国/2018/安徽XCGQ
基因型III：BOT 1/99
基因型IV：ASFV-War；RSA/1/99/W
基因型VI：MOZ 94/1
基因型VII：VICT/90/1；ASFV-Mku；RSA/1/98
基因型VIII：NDA/1/90；KAL88/1；ZAM/2/84；JON89/13；KAV89/1；DEZda；AFSV-Mal；马拉维LIL 20/1
基因型IX：UGA/1/95
基因型X：BUR/1/84；BUR/2/84；BUR/90/1；UGA/3/95；TAN/Kwh12；HindeII；ASFV-Ken；强毒乌干达65。
ASFV分离株
本发明的减毒ASF病毒可以衍生自野生型ASF病毒分离株，但包括其基因组中的突变使得以下基因的表达和/或活性被破坏：MGF 360基因12L、13L和14L和MGF 505基因1R。
本发明的减毒ASF病毒可以衍生自野生型ASF病毒分离株，但缺少K145R基因或B125R基因的功能形式。
术语“野生型”表示该病毒(在某个时间点)存在于野外，并且是从自然宿主如家猪、蜱或疣猪中分离出来的。下表1总结了迄今为止描述的ASFV分离株及其基因库登录号。
表1
本发明的减毒ASFV的基因组可以对应于任何ASFV基因型。本发明的减毒ASFV的基因组可以基本上对应于任何ASFV基因型。
术语“对应于”是指本发明的减毒ASFV基因组的其余部分与野生型毒株相同。“基因组的其余部分”是指除本发明所涉及的以下基因之外的所有基因：MGF 360 10L、11L、12L、13L和14L以及MGF 505 1R、2R和3R以及B125R和K145R。本发明涉及的基因也可以对应于野生型毒株。在实施方案中，MGF 360 10L、11L、12L、13L和14L以及MGF 505 1R、2R和3R以及B125R和K145R对应于野生型毒株。在MGF 360 12L、13L和14L以及MGF 505 1R对应于野生型毒株的情况下，它们的表达和活性可以被基因间区域如启动子中的突变破坏。在实施方案中，MGF 360 12L、13L和14L以及MGF 505 2R和3R以及B125R和K145R对应于野生型毒株。换言之，本发明的减毒ASFV的基因可以与野生型毒株的基因相同。在实施方案中，本发明的减毒ASFV的基因除MGF 360 12L、13L和14L以及MGF 505 1R之外，与野生型毒株的基因相同。在实施方案中，本发明的减毒ASFV的基因除MGF 360 12L、13L和14L以及MGF 505 1R以及B125R和/或K145R之外，与野生型毒株的基因相同。
除了基因组的其余部分可以包含一个或多个突变之外，术语“基本上对应于”的意思与“对应于”相同。一个或多个突变可以在其他基因中(即不在本发明涉及的基因中)。
减毒ASFV的基因组可以对应于或基本上对应于基因型I。减毒ASFV的基因组可以对应于或基本上对应于基因型II。减毒ASFV的基因组可以对应于或基本上对应于基因型III。减毒ASFV的基因组可以对应于或基本上对应于基因型IV。减毒ASFV的基因组可以对应于或基本上对应于基因型V。减毒ASFV的基因组可以对应于或基本上对应于基因型VI。减毒ASFV的基因组可以对应于或基本上对应于基因型VII。减毒ASFV的基因组可以对应于或基本上对应于基因型VIII。减毒ASFV的基因组可以对应于或基本上对应于基因型IX。减毒ASFV的基因组可以对应于或基本上对应于基因型X。
本发明的减毒ASFV的基因组可以对应于或基本上对应于强毒ASFV毒株的基因组。已知的强毒ASF病毒株包括：格鲁吉亚2007/1、贝宁97/1、肯尼亚、马拉维Lil20/1、Pretorisuskop/96/4和Tengani 62。减毒ASFV的基因组可以对应于或基本上对应于格鲁吉亚2007/1毒株的基因组。减毒ASFV的基因组可以对应于或基本上对应于贝宁97/1毒株的基因组。
本发明的减毒ASFV的基因组可以对应于或基本上对应于毒力目前未知的ASFV毒株的基因组，例如：Mkuzi、Warmbaths和Warthog。
在实施方案中，本发明的减毒ASFV的基因组不对应于OURT88/3的基因组。在实施方案中，本发明的减毒ASFV不是OURT88/3。
多基因家族(MGF)
ASFV含有存在于基因组的左右可变区的五个多基因家族。MGF以每个基因中存在的平均密码子数命名：MGF 100、110、300、360和505/530。MGF 300、360和505/530成员的N端区域彼此具有显著的相似性。已经表明MGF 360和505家族编码涉及促进感染细胞存活和抑制I型干扰素反应的宿主范围功能所必需的基因。
根据本发明的减毒ASFV破坏了以下基因的表达和/或活性：
多基因家族(MGF)360 12L、13L和14L，以及
MGF 505 1R，
并且包含以下基因的功能形式：
(i)MGF 360 10L和/或11L，以及
(ii)MGF 505 2R和/或3R。
换言之，根据本发明的减毒ASFV缺乏以下基因的功能形式：
MGF 360 12L、13L和14L，以及
MGF 505 1R，
并且包含以下基因的功能形式：
(i)MGF 360 10L和/或11L，以及
(ii)MGF 505 2R和/或3R。
这些基因在多种ASFV毒株基因组中的位置提供于下表2。还提供了每个基因与相应的贝宁97/1基因的序列同一性。
表2a–MGF 360-10L
表2b–MGF 360-11L
表2c–MGF 360-12L
表2d–MGF 360-13L
表2e–MGF 360-14L
表2f–MGF 505-1R
表2g–MGF 505-2R
表2h–MGF 505-3R
下面给出了来自不同毒株的MGF基因的基因(即核苷酸)序列。
MGF 360 10L基因序列
SEQ ID No.11–贝宁97/1MGF 360 10L(NC_044956.1:19607-20677)
TTATAACGATGTATCATTGATGTCATAATTCAAATAGGCCAACATACTTTTTGATTTATAGTTTTTTAATAGACGATATATTTTGTTAGGATCTGCTTCTTTTAACGTTAATAGCGAGGAGTCTGGACTATAAATGTCTAATGATAAACGATGAGATATCAAATAGTAATTCTGTTGCTCTGCCAAGGCTTTTGCCTCTTCAAAGGCATCGGCCCCCAGATCTATACAAAAGAACAGGTTATCCATATTATAGAATCGTATGGAGGCAATCATGGCCAAATTAATATTAGCTCCTAAGATAAAACAATAATATATAGTTAAAAAATTGTTATCTTTTGTGCAGGCTATCCGCATCATTTCATCCATGTCCATACGGATTTTTTCTTTTTCGTACAAATTATGTAGGTCAAACAGCTTATTATAGCAAAGAGCACATGTTAACCACCACGTATTCAGATACTTAAAATGTTGGTAAACATAAGAAATGGCCTCCCTAAGATTATCCTGCAATGCCACGATAAAACAGTATATAGTTAACATATCACCATCCGAAATATTACTTAATACGTTGGTATCTTCTGCTAAATTTTTTAGCTTCCAATGTATACACGACTTTATTTCCCTTATAATGACATAGGCTGAAAAGGGATTGTCATTAAAAAATTTAAGACATAAGATAATATTATTACTAGTAGTGTTAGGATGTATTAATTTAAAGAATATGTGCATAATCTTCTTTTTATCCACTTGGTACTTGGCTCCTAATTCCCAGCAAAATTCTCGAATAGGTGGCGTATTCGCGCAAATTAACCCATAGTTGATGTCTGCGCCCCAATCCGTAAACATTTTTATTAATTGATAGTTGTTTTCCTTTGTAGCCAACATTAGTGCCGTATTAAGGTCCAAGCCATCTGCAAAGTTTGGCAGCTTTATCAGCATATGTTTGCAATCAAGTGAAATTGGAGCCTTATACCACCATAGCCCGCAGCGTTCTAAGATAACATGGTAATCAATAGATACATGCTGACTGGCTAATACCTTTTTGGCGAAGGATTGCAAGGAAGGAACCAT
SEQ ID No.12–中国/2018/安徽XCGQ MGF 360 10L(MK128995.1:25402-26439)
CTAGGCCAACATACTTTTTAATTTATAGTTTTTTAATAGATGATATATTTTGCTAGGATCTGCTTCTTTTAACGTTAATAGCGAGGAGTCTGCACTATAAATGTCTAATGATAAATGATGAGATATCAAATAGTAATTCCGTTGCTCTGCTAGGGCCTTTGCCTCTTCAAAGGCGTCGGCTCCCAGATCTATACAAAAGAACAAGTTATCCATATTATAAAATCGTACGCAGGCAAGCATAGCTGAATTAATATTAGCTCCTAAGAGAAAACAATAATATATGGTTAAAAAATTGTTATCTTTTGTGCAGGCCATCCGCATCATTTCATCCACGTCCATGCGGATCTTTTCCTTTTCATACAAATTATGTAGGTCAAACAGCTTATTAAAACAAAGAGCACAGATTAACCACCACGTATTTAGATACTTAAAATGTTGGTAAACATAAGAAATGGCCTCCCTAAGATTATCCTGCAATGCCACTATAAAACAGTATATCGTTAACATATCACCATCCGACATATTACTTAATATGTCGGTGTCTTCTACTAACCTTTTCAACTTCCAATATATGGATGACCTTATTTCCCTTATAATGACATAGGCTGGAAAGGGATTATCATTAAAAAGTTTAAGACATAAGATAATATTACTGCTAGTAGTGCCAGGGTGTATTAATTTAAAGAACATGTGCATAATCTTCTTTTTATCCACGCGGTACTTGGCTCCTAATTCCCAGCAAAATTCTCGAACAGGCGGCGTATTGGCGCAAATTAACCCATAGTTGATGTCTGCGCCCCATTCTGTAAACAGTTTTATTAACTGATAGTTGTTTTCCTTTGTAGCCAACATTAGTGCCGTATTAAGGTCCAAGCCGTCTGCAAAGCTTGGCAGCTTTATCAGCATATGTTTGCAATCAAGGGAAATTGGGGCCTTATACCACCATAGTCCGCAGCGTTCTAAGATAACATGGTACTCAATAGATACTTGCTGTCTGGCTAGTACCTTTTTGGCGAAGGATTGTAAGGAAGGAAACAT
SEQ ID No.13–格鲁吉亚2007/1MGF 360 10L(LR743116.1:26373-27410)
CTAGGCCAACATACTTTTTAATTTATAGTTTTTTAATAGATGATATATTTTGTTAGGATCTGCTTCTTTTAACGTTAATAGCGAGGAGTCTGCACTATAAATGTCTAATGATAAATGATGAGATATCAAATAGTAATTCCGTTGCTCTGCTAGGGCCTTTGCCTCTTCAAAGGCGTCGGCTCCCAGATCTATACAAAAGAACAAGTTATCCATATTATAAAATCGTACGCAGGCAAGCATAGCTGAATTAATATTAGCTCCTAAGAGAAAACAATAATATATGGTTAAAAAATTGTTATCTTTTGTGCAGGCCATCCGCATCATTTCATCCACGTCCATGCGGATCTTTTCCTTTTCATACAAATTATGTAGGTCAAACAGCTTATTAAAACAAAGAGCACAGATTAACCACCACGTATTTAGATACTTAAAATGTTGGTAAACATAAGAAATGGCCTCCCTAAGATTATCCTGCAATGCCACTATAAAACAGTATATCGTTAACATATCACCATCCGACATATTACTTAATATGTCGGTGTCTTCTACTAACCTTTTCAACTTCCAATATATGGATGACCTTATTTCCCTTATAATGACATAGGCTGGAAAGGGATTATCATTAAAAAGTTTAAGACATAAGATAATATTACTGCTAGTAGTGCCAGGGTGTATTAATTTAAAGAACATGTGCATAATCTTCTTTTTATCCACGCGGTACTTGGCTCCTAATTCCCAGCAAAATTCTCGAACAGGCGGCGTATTGGCGCAAATTAACCCATAGTTGATGTCTGCGCCCCATTCTGTAAACAGTTTTATTAACTGATAGTTGTTTTCCTTTGTAGCCAACATTAGTGCCGTATTAAGGTCCAAGCCGTCTGCAAAGCTTGGCAGCTTTATCAGCATATGTTTGCAATCAAGGGAAATTGGGGCCTTATACCACCATAGTCCGCAGCGTTCTAAGATAACATGGTACTCAATAGATACTTGCTGTCTGGCTAGTACCTTTTTGGCGAAGGATTGTAAGGAAGGAAACAT
SEQ ID No.14–Ken05/Tk1 MGF 360 10L(NC_044945.1:27310-28380)
TTACGACGTTGTATCATTATTGTGATAATCCAAATAGGCCGACATACTTTTTGATTTATAATTGTTTAATAGATGGTATATTTTTTTAGGGTTCGCTTCTTTTAGCGTGAATAGAGAGGGATCTGGATGATAGATATCTAATGACAAACGATGTGATATTAAATAATAGTCCCGCTGCTCTGCTAGGGCTTTTGCCTCTTCGAAGGCATTGGCCCCCAAGTCTATACAAAAGAACAGATTATCTATATTAAAAAACTGTATGGCAGCAAGCATCGCCATATTGATATCGGCCCCTAAAATAAAACAATAATACATCGTTAAAAAGTTGTTATCTTTCGTGCAAGCTATGCGCATCATTTCATTAATGTCTATGCGAATTTTTTCCTGCTCATAGAGATAATGGAGGTCAAACAGTTTATTAAAACACAGAGCACAGATTAACCACCACGTATTCAGGTGCTTAAAATGTTGGTAAAAATACGAGACGGCCTCCCTAAGACCATTCTGCAAGGCCACCATAAAACAATATAAAGTTAGCATATCGCCGTCCGAAACATCGCGTAGTAGGTCTTCGTCTTCTACTAACCTCCTCAGCCTCCAATAAAGAGACGACTTTATTTCCCTTATAATCACATAGGTAGGAAAAGGATTCTCATTAAAAAGCTTATGACATAAGATAATATATTGACTCGTTTTGTTCTCTATAAATTTAAAAAACATATGCATCACCTTTTTTTTATCTAAGCGATAGTTCGCTCCTAATTCCCAACAAAACTCTCGAGTAGGCTGTGTATTGGCACAAATGTATCCATAGTTGATGTTTGCACCCCACTCCGTGAACAGTTTTATTAATTGATAGTTGTTTTCCTTTGCAGCTATCATCAATGCCGTATTGAGGTCCAGGCCATCCGCAAAGTATGGCAACCTTATTAACATGTGTTTACAATCAAGTGAAATTGGAGCCTTATACCACCATAACCCGCAGCGCTTCAAAATATGATAGTAGTCTTCAGGCAGCACATGCTGGCTGGCTAATATCTTTTTGGCGAAAGATTGCAGGGAAGGAAACAT
SEQ ID No.15–Ken06.Bus MGF 360 10L(NC_044946.1:23437-24507)
TTACGACGTTGTATCATTGATGTGATAATCCAAATAGGCCAACATACTTTTTGATTTATAGTTGTTTAATAGATGGTATATTTTTTTAGGGTTCGCTTCTTTTAGCGTGAATAGAGAGGGATCTGGATGATAGATATCTAATGACAAACGTTGTGATATTAAATAATAGTCCCGCTGCTCTGCTAGGGCTTTTGCCTCTTCGAAGGCATTGGCTCCCAAGTCTATACAAAAGAACAGATTATCTATATTAAAGAACTGTATGGCAGCAAGCATGGCCATATTGATATCGGCCCCTAAAATAAAACAATAATACATCGTTAAAAAGTTATTATCTTTCGTGCAAGCTATGCGCATCATTTCATTAATGTCTATGCGAATCTTTTCCTGCTCATAGAGATAATGGAGGTCAGACAGTTTATTAAAATACAGAGCACAGATTAACCACCACGTATTCATGTGCTTAAAATGTTCGTAAAAATACGAGACGGCCTCCCTAAGATCATTCTGCAAGGCCACCATAAAACAATATATAGTTAGCATATCGCCGTCCGAAACATCACGTAGTAGGTCTTCATCTTCTACTAACCTCCTCAGCCTCCAATAAAGAGACGACTTTATTTCCCTTATAATCACATAGGTAGGAAAAGGATTCTCATTAAAAAGCTTATGACATAAGATAATATATTGACTTGTTTTGTTCTCTATAAATTTAAAGAACATGTGTATCACCTTTTTTTTATCCATGCGATAGTTCGCTCCTAATTCCCAACAAAACTCTCGGGTAGGCTGTGTATTGGCACAAATGTATCCATAGTTGATGTTTGCACCCCACTCCGTGAATAGTTTTATTAATTGATAGTTGTTTTCCTTTGCAGCTATCATCAATGCCGTATTGAGATCCAGGCCATCCGCAAAGTATGGCAACCTTATTAACATGTGTTTGCAATCAAGTGAAATTGGAGCCGTATACCACCATAACCCGCAGTATTTCAAAATATGATAGTAGTCTTCAGGCAGCACATGCTGACTGGCTAATATCTTTTTGGCGAAAGACTGTAAAGAAGGAAACAT
SEQ ID No.16–肯尼亚1950MGF 360 10L(AY261360.1:29558-30628)
TTACGACGTTGTATCATTAATGTGATAATCCAAATAGGCCGACATACTTTTTGATTTATAGTTGTTTAATAGATGGTATATTTTTTTAGGGTTCGCTTCTTTTAGCGTGAATAGAGAGGGATCTGGATGATAGATATCTAATGACAAACGATGTGATATTAAATAATAGTCCCGCTGCTCTGCTAGGGCTTTTGCCTCTTCGAAGGCATTGGCCCCCAAGTCTATACAAAAGAACAGATTATCCATATTAAAGAACTGTATGGCAGCAAGCATGGCCATATTGATATCGGCCCCTAAAATAAAACAATAATACATCGTTAAAAAGTTGTTATCTTTCGTGCAAGCTATGCGCATCATTTCATTAATGTCTATGCGAATTTTTTCCTGCTCATAGAGATAATGGAGGTCAAACAGTTTATTAAAACACAGAGCACAGATTAACCACCACGTATTCAGGTGCTTAAAATGTTGGTAAAAATACGAGACGGCCTCCCTAAGATCATTCTGCAAGGCCACCATAAAACAATATAAAGTTAGCATATCGTCGTCCGAAACATCGCGTAGTAGGTCTTCGTCTTCTACTAATCTCCTCAGCCTCCAATAAAGAGACGACTTTATTTCCCTTATAATCACATAGGTAGGAAAAGGATTCTCATTAAAAAGCTTATGACATAAGATAATATACTGACTCGTTTTGTTCTCTATAAATTTAAAAAACATATGCATCACCTTTTTTTTATCTAAGCGATAGTTTGCTCCTAATTCCCAACAAAACTCTCGAGTAGGCTGTGTATTGGCACAAATGTATCCATAGTTGATGTTTGCACCCCACTCCGTGAACAGTTTTATTAATTGATAGTTGTTTTCCTTTGCAGCTATCATCAATGCCGTATTGAGGTCCAGGCCATCCGCAAAGTATGGCAACCTTATTAACATGTGTTTACAATCAAGTGAAATTGGAGCCTTATACCACCATAACCCGCAGCGCTTCAAAATATGATAGTAGTCTTCAGGCAGCACATGCTGGCTGGCTAATATCTTTTTGGCGAAAGATTGCAGGGAAGGAAACAT
SEQ ID No.17–L60 MGF 360 10L(NC_044941.1:19956-21026)
TTATAACGATGTATCATTGATGTCATAATTCAAATAGGCCAACATACTTTTTGATTTATAGTTTTTTAATAGACGATATATTTTGTTAGGATCTGCTTCTTTTAACGTTAATAGCGAGGAGTCTGGACTATAAATGTCTAATGATAAACGATGAGATATCAAATAGTAATTCTGTTGCTCTGCCAAGGCTTTTGCCTCTTCAAAGGCATCGGCCCCCAGATCTATACAAAAGAACAGGTTATCCATATTATAGAATCGTATGGAGGCAATCATGGCCAAATTAATATTAGCTCCTAAGATAAAACAATAATATATAGTTAAAAAATTGTTATCTTTTGTGCAGGCTATCCGCATCATTTCATCCATGTCCATACGGATTTTTTCTTTTTCGTACAAATTATGTAGGTCAAACAGCTTATTATAGCAAAGAGCACATGTTAACCACCACGTATTCAGATACTTAAAATGTTGGTAAACATAAGAAATGGCCTCCCTAAGATTATCCTGCAATGCCACGATAAAACAGTATATAGTTAACATATCACCATCCGAAATATTACTTAATACGTTGGTATCTTCTGCTAAATTTTTTAGCTTCCAATGTATACACGACTTTATTTCCCTTATAATGACATAGGCTGAAAAGGGATTGTCATTAAAAAATTTAAGACATAAGATAATATTATTACTAGTAGTGTTAGGATGTATTAATTTAAAGAATATGTGCATAATCTTCTTTTTATCCACTTGGTACTTGGCTCCTAATTCCCAGCAAAATTCTCGAATAGGTGGCGTATTCGCGCAAATTAACCCATAGTTGATGTCTGCGCCCCAATCCGTAAACATTTTTATTAATTGATAGTTGTTTTCCTTTGTAGCCAACATTAGTGCCGTATTAAGGTCCAAGCCATCTGCAAAGTTTGGCAGCTTTATCAGCATATGTTTGCAATCAAGTGAAATTGGAGCCTTATACCACCATAGCCCGCAGCGTTCTAAGATAACATGGTAATCAATAGATACATGCTGACTGGCTAATACCTTTTTGGCGAAGGATTGCAAGGAAGGAACCAT
SEQ ID No.18–马拉维Lil-20/1(1983)MGF 360 10L(AY261361.1:23735-24802)
TTACACTGTGTCATGCCCATCATAGTCAAAATATACCATCATATTTTTTGATTTATAGTTTTTTAATAGATGATATATTTTTTTAGGATCTGCTTCTTTTAACGTTAATAGCGAGGAGTCTGGACTATAAATATCTATTGATAAACGATGATACATCAAAAAGTAATTCCGCTGGTCTGCCAGGGCTTTTGCCTCTTCAAAGGCATCGGCTCCCAGGTCTATACAAAAGAACAAGTTATCCATATTATAGAATTGTACGCAGGCAAGCATAGCCTGATTAATATTAGCTCCTAAGAGAAAACAGTAATATATGGTTAAAAAGTTGTTATCTTTAGTGCAGGCTATGCACATCATTTCATCCATGTCCATGCGGATCTTTTCCTTTTCATACAAATCATGTAGGTCAAACAGCTTATTAAAACAAAGAGCACAGATTAACCACCACGTATTCAGATGCTTAAAATGTTGGTAAAAATAAGAAATGGCCTCCCTAAGATTATCCTGCAATGCCAGGATAAAACAGTATATAGTCAACATATCATCATCCGACATATTACTTAATATGTCAGTGTCTTCTACTAACCTTCTCAGCTTCCAATATATAGACGACTTTATTTCCCTTATAATGACATAGGTTGGAAAAGGATTATTATTAAAAAGTTTAAGACATAAGATAATATTACTACTAGTAGTGCCATGATGTATTAATTTAAAAAACATATGCATAACCTTATTTTTATCCACTTGGTACTTGGCTCCTAATTCCCAGCAAAATTCTCGAACAGGCGGCGTATTAGCGCAAATTAATCCATAGTTGATGTCCGCGCCCCATTCCGTAAACAGTTTTATTAACTGATAGTTGTTTTCCTTTGTAGCCAACATTAGTGCCGTATTAAGGTCCAAGCCATCTGCAAAGCTTGGCAGCTTTATTAACATATGTTTGCAATCAAGTGAAATTGGAGCCTTATACCACCATAGTCCGCAATGTTTTAAGATATAATGATAATCAATGGATACATGATGTCTAGCTAATACCTTTTTGGCGAAGGATTGTAAAGAAGGAAACAT
SEQ ID No.19–Mkuzi 1979MGF 360 10L(AY261362.1:27069-28139)
TTATAACGATGTATCATTGATGTCATAATTCAAATAGGCCAACATACTTTTTGATTTATAGTTTTTTAATAGACGATATATTTTGTTAGGATCTGCTTCTTTTAACGTTAATAGCGAGGAGTCTGGACTATAAATGTCTAATGATAAACGATGAGATATCAAATAGTAATTCTGTTGCTCTGCCAAGGCCTTTGCCTCTTCAAAGGCATCGGCCCCCAGATCTATACAAAAGAACAGGTTATCCATATTATAGAATCGTATGGAGGCAATCATGGCCAAATTAATATTAGCTCCTAAGATAAAACAATAATATATAGTTAAAAAATTGTTATCTTTTGTGCAGGCTATCCGCATCATTTCATCCATGTCCATACGGATTTTTTCTTTTTCGTACAAATTATGTAGGTCAAACAGCTTATTATAGCAAAGAGCACATGTTAACCACCACGTATTCAAATACTTAAAATGTTGGTAAACATAAGAAATGGCCTCCCTAAGATTATCCTGCAATGCCACGATAAAACAGTATATAGTTAACATATCACCATCCGAAATATTACTTAATACGTTGGTATCTTCTGCTAAATTTTTTAGCTTCCAATGTATACACGACTTTATTTCCCTTATAATGACATAGGCTGAAAAGGGATTGTCATTAAAAAATTTAAGACATAAGATAATATTACTACTAGTAGTGCTAGGATGTATTAATTTAAAGAATATGTGCATAATCTTCTTTTTATCCACTTGGTGCTTGGCTCCTAATTCCCAGCAAAATTCTCGAATAGGTGGCGTATTCGCGCAAATTAACCCATAGTTGATGTCTGCGCCCCAATCCGTAAACATTTTTATTAATTGATAGTTGTTTTCCTTTGTAGCCAACATTAGTGCCGTATTAAGGTCCAAGCCATCTGCAAAGTTTGGCAGCTTTATCAGCATATGTTTGCAATCAAGTGAAATTGGAGCCTTATACCACCATAGCCCGCAGCGTTCTAAGATAACATGGTGATCAATAGATACATGCTGACTGGCTAATACCTTTTTGGCGAAGGATTGCAAGGAAGGAAACAT
SEQ ID No.20–Pretorisuskop/96/4MGF 360 10L(AY261363.1:26116-27186)
TTATAACGTTGTATTATTGACGTCATAATTCAAATAGGCCAATATACTTTTTGATTTATAGTTTTTTAATAGATGATATATTTTGTTAGGATCCGCTTCTTTTAACGTTAATAACGAGGAATCTGGACTATAAATGTCTAATGATAAACAATGAGATATCAAAAAGTAATTCCGTTGCTCTGCCAGGGCTTTTGCCTCCTCAAAGGCATCGGCCCCCAGGTCTATACAAAAGAATAAGTTATCTATGTTATAGAATTGTATGGAGGCAATCATAGCTAAATTAATATTAGCTCCTAAGATAAAACAATAATATATGGTTAAAAAATTGTTATCTTTTGTGCAGGCTATCCGCATCATTTCATCCATGTCCATGCGGATCTTTTCCTTTTCATACAAATGATGTAGGTCAAACACCTTATTATAGCAAAGAACACATGTTAACCACCACGTATTCAGATACTTAAAATGTTGGTAAACATAAGAAATGGCCTCCCTAAGATTATCCTGCAATGCCACGATAAAACAGTATATAGTTAACATATCTCCATCCGAAATATTACTTAATACGTTGGTATCTTCTGCTAACTTTTTTAGCTTCCAATGTATACACGACTTTATTTCCCTTATAATGACATAGGCTGAAAAGGGATTGTCATTAAAAAGTTTAAGACATAAGATAATATTACTACTAGTAGTGCTAGGATGTATTAATTTAAAGAATATGTGCATAATCTTCTTTTTATCCACTTGGTACTTGGCTCCTAATTCCCAGCAAAATTCTCGAACAGGTGGCGTATTCGCGCAAATTAACCCATAGTTGATGTCTGCGCCCCAATCCGTAAACATTTTTATTAATTGATAGTTGTTTTCCTTTGTAGCCAACATTAGTGCCGTATTAAGGTCCAAGCCATCTGCAAAGTTTGGCAGCTTTATCAGCATATGTTTGCAATCAAGTGAAATTGGAGCCTTATACCACCATAGCCCGCAGCGTTCTAAGATAATATGGTGATCAATGGATACATGCTGTCTGGCTAGTACCTTTTTGGCGAAGGATTGTAAGGAAGGAAACAT
SEQ ID No.21–Tengani 62 MGF 360 10L(AY261364.1:20530-21600)
TTATAACAATGTATCATTGATATCATCATTCAAATAGGCCAACATATTTTTTGATTTATAGTTTTTTAATAGATGATTTATTTTGTTAGGATCTGTTTCTTTTAACGTTAATAGCAAGGAGTCTGGCTTATAAATGTCTAATGATAAACGATGAGATATTAAATAGTAATTCCGTTGCTCTGCCAGGGCTTTTGCCTCTTCAAAGGCGTCGGCTCCCAGATCTATACAAAAGAACAAGTTATCCATATTATAAAATCGTACGCAGGCAAGCATAGCTGAATTAATATTAGCTCCTAAGAGAAAACAATAATATATAGTTAAAAAATTGTTATCTTTTGTGCAGGCCATCCGCATCATTTCATCCACGTCCATGCGGATCTTTTCCTTTTCATACAAATTATGTAGGTCAAACAGCTTATTAAAACAAAGAGCACAGATTAACCACCACGTATTTAGATACTTAAAATGTTGGTAAACATAAGAAATGGCCTCCCTAAGATTATCCTGCAATGCCACTATAAAACAGTATATCATTAACATATCACCATCCGACATATTACTTAATATGTCGGTGTCTTCTACTAACCTTTTCAGCTTCCAATATATGGATATCCTTATTTCCCTTATAATGACATAGGCTGGAAAGGGATTATCATTAAAAAGTTTAAGACATAAGATAATATTACTGCTAGTAGTGCCAGGATGTATTAATTTAAAGAACATGTGTATAATCTTCTTTTTATCCACGCGGTGCTTGGCTCCTAATTCCCAGCAAAATTCTCGAACAGACGGCGTATTGGCGCAAATTAACCCATAGTTGATGTCTGCGCCCCATTCCGTAAACAGTTTTATTAACTGATAGTTATTTTCCTTTGTAGCCAACATTAGTGCCGTATTAAGGTCCAAGCCGTCTGCAAAGCTTGGCAGCTTTATCAGCATATGTTTGCAGTCAAGTGAAATTGGAGCCTTATACCACCATAGTCCGCAACGTTCTAAGATAACATGGTACTCAATAGATACTTGCTGTCTGGCTAGTACCTTTTTGGCGAAGGATTGTAAGGAAGGAAACAT
SEQ ID No.22–Warmbaths MGF 360 10L(AY261365.1:25300-26361)
TCATATTGTATCATCATGGTTAAAATATGCCGTCATATTTTTTGATTTATAGTTTTTTAATAGATGATATATTTTGTTAGGGTCCGCTTCTTTTAACGTTAATAGCGAGGAGTCTGGACTATAAATGTCTAATGATAAACGATGAGATATCAAAAAGTAATTCCGTTGCTCTGCCAGAGCCTTTGCCTCTTCAAAGGCGTCGGCCCCCAGGTCTATACAAAAGAACAGGTTATCCATATTATAGAATCGTATGGAGGCAATCATGGCCAAATTAATATTAGCTCCTAAGATAAAACAATAATATATAGTTAAAAAATTGTTATCTTTTGTGCAGGCTATCCGCATCATTTCATCCATGTCCATGCGGATTTTTTCCTTTTCGTACAAATTATGTAGGTCAAACAGCTTATTAAAACAAAGAGCACAGATTAGCCACCACATATTCAGATACTTAAAATGTTGGTAAACATAAGAAATGGCCTCCCTAAGATTATCCTGCAATGCCACCATAAAACAGTATATCGTTAACATATCACCATCTGAAATATCACTTAATACGTCGGTGTCTTCTACTAACTTTCTCAGCTTCCAATATATGGATGACTTTATTTCCCTTATAATGACATAGGCTGAAAAGGGGTTATCATTAAAAAGTTTAAGACATAAGATAATATTACTGCTAGTAGTGCCAGGATGTATTAATTTAAAGAACATGTGCATAATCTTCTTTTTATCCACGCGGTACTTGGCTCCTAGTTCCCAGCACAATTCTCGAACAGGCGGTGTATTGGCGCAAATTAACCCATAGTTGATGTCTGCGCCCCATTCCGTAAACAGTTTTATTAACTGATAGTTGTTTTCCTTTGTAGCCAACATTAGTGCCGTATTAAGGTCCAAGCCATCTGCAAAGCTTGGCAGCTTTATCAGCATATGTTTGCAATCAAGTGAAATTGGAGCCTTATACCACCATAGTCCGCAGCGTTCTAAGATAACATGGTAATCAATAGATACATGCTGTCTGGCTAGTACCTTTTTGGCGAAGGATTGTAAGGAAGGAAACAT
SEQ ID No.23–Warthog MGF 360 10L(AY261366.1:22069-23130)
TCATATTGTATCATCATGGTTAAAATATGCCGTCATATTTTTTGATTTATAGTTTTTTAATAGATGATATATTTTGTTAGGGTCCGCTTCTTTTAACGTTAATAGCGAGGAGTCTGGACTATAAATGTCTAATGATAAACGATGAGATATCAAAAAGTAATTCCGTTGCTCTGCCAGGGCTTTTGCCTCTTCAAAGGCATCGGCCCCCAAGTCTATACAAAAGAACAGGTTATCCATATTATAAAATCGTATGGAGGCAATCATGGCCAAATTAATATTAGCTCCTAAGATAAAACAATAATATATAGTTAAAAAATTGTTATCTTTTGTGCAGGCTATCCGCATCATTTCATCCATGTCCATGCGGATTTTTTCCTTTTCGTACAAATTATGTAGGTCAAACAGCTTATTAAAACAAAGAGCACAGATTAGCCACCACGTATTCAGATATTTAAAATGTTGGTAAACATAAGAAATGGCCTCCCTAAGATTATCCTGCAATGCCACCATAAAACAGTATATCGTTAACATATCACCATCCGAAATATTACTTAATACGTCGGTGTCTTCTACTAACTTTTTCAGCTTCCAATATATGGATGACTTTATTTCCCTTATAATGACATAGGCTGAAAAGGGGTTATCATTAAAAAGTTTAAGACATAAGATAATATTACTGCTAGTAGTGCCAGGATGTATTAATTTAAAGAACATGTGCATAATCTTCTTTTTATCCACGCGGTACTTGGCTCCTAGTTCCCAGCACAATTCTCGAACAGGCGGCGTATTGGCGCAAATTAACCCATAGTTGATGTCTGCGCCCCATTCCGTAAACAGTTTTATTAACTGATAGTTGTTTTCCTTTGTAGCCAACATTAGTGCCGTATTAAGGTCCAAGCCATCTGCAAAGCTTGGCAGCTTTATCAGCATATGTTTGCAATCAAGGGAAATTGGAGCCTTATACCACCATAGTCCGCAGCGTTCTAAGATAACATGGTAATCAATAGATACATGCTGTCTGGCTAGTACCTTTTTGGCGAAGGATTGTAAGGAAGGAAACAT
在实施方案中，本发明的减毒ASFV包含MGF 360 10L的功能形式。适当地，MGF 36010L的功能形式包含SEQ ID No.11、12、13、14、15、16、17、18、19、20、21、22或23的序列。适当地，MGF 360 10L的功能形式包含与SEQ ID No.11、12、13、14、15、16、17、18、19、20、21、22或23具有至少70％、至少80％、至少90％或至少95％的同一性的序列。适当地，MGF 360 10L的功能形式由SEQ ID No.11、12、13、14、15、16、17、18、19、20、21、22或23的序列组成。
MGF 360 11L基因序列
SEQ ID No.24–贝宁97/1MGF 360 11L(NC_044956.1:20703-21764)
TTATCTTTGTTCATAATCAAGAAAAATCCCCATATTTATTGAGTGATAATTTTTTAACATGTAATTTATTTTTTCAGGGTCCATAACGTTCGACAACAGAGAAATGACTGGATTGTAATGCTTTAATGATAAGGCATGGGCTATCAGATAATTTTCCTTTTGTTCTGCCAAAGCTTTGCCCTCCTCAAAGGCGTTGGCGCCCAGGTCTATACAAAAGAACAGGTTTCCAAGATTATAGTTTTGTATGGAAACCAGCATGGCTTGATTGATGTTGGCTCCCATGATAAAACAGTAGTAAATGGCCGAATAGCTATAATCTTGGATGCAGGCTATGTGCATCATTTCATCGATATCCATGCGGACCCTTTCTATTTCATACAGCTCGTGAAGGTCGAACACGTTGTTGTAAAAAAGGGCGCACATGAGCCGCCACCGATGTAGGCGCGGGTATTTCTGGTAAAAGTAGCGAATAGCATCTTTGAGGTCATAGTCCACCGCTATAGCATACCAGTATTTGGTTAAAACAGTGCTAAAGCTATCATCATGGTCTAGCATGAAGGTTATCTCCATGAGCCCTCTTAACTCCCACATGATTTCCCCCCTCAGATCCAGATTATCTATAATCCTTAAATTGGGGTTATTGGAAAACACCTCGTGGCAAAAGATAATATTGCTACTGGTTTTATCGCGCGTCGTATCAAAGAAAATTTTTAAAATATACTCTCTTTCTAAATATTCTTTGGCTCCCAGCTCTTTGCACAGATCACGGGTATTTTCCGTGAGAGCACAAATCATTCCATAGTTAATATCTGCACCCCATTCAGTAAACAGCTTTATCAAGTCATGATTATTCTCCTTCACGGCTTTCATCAGTCCTATGTTTAACTCGATACCTTGACTAAAGCAGGTTGACCTTATAAATAGTTTATTACGTCGAATATGAAGCATAATGGGGCCATTATGCCACCACAGGCCACAACACTTCAGGATATGATAATGATCCACCGACACGCACTGCCCGGCCAGTACTTTCTTCGTGAGGGATTGCAGGGAAGGCAACAT
SEQ ID No.25–中国/2018/安徽XCGQ MGF 360 11L(MK128995.1:26467-27528)
TTATCTTTGTTCATAATCAAGAAAAATCCCCATATTTATTGAGTGATAATTTTTTAACATGCAATTTATTTTTTCAGGGTCCGTAACGATCGACAACAGAGAAATAACCGGATTGTAATGCTTTAATGATAAGGCATGGGCTATCAGATAATTTTCCTTTTGTTCTGCCAAAGCTTTGCCCTCCTCAAAGGCATCGGCACCCAGGTCTATACAAAAGAACAGGTTTCCAAGATTATAGTTTTGTATGGAAACAAGCATGGCTTGATTGATGTTGGCTCCCATGATAAAACAGTAGTAAATGGCCGAATAGCTATAATCTTGGATGCAGGCTATGTGCATCATTTCATCAATATCCATGCGGACCCTTTCTATTTCGTACAGCTCGTGAAGGTCGAACACGTTGTTGTAAAAAAGGGCGCACATGAGCCGCCACCTATGTAGACGCGGGTATTTCTGGTAAAAGTAGCGGATAGCATCTTTGAGGTCATAGTCCACCGCTATCGCGTACCAGTATTTGGTTAAAACAGTGCTAAAGCTATCATCATGGTCCAGCATGAAGGTTATCTCCATGAGCCCTCTTAACTCCCACATGATTTCCCCCCTCAGATCCAGATTATCTATAATCCTTAAATTGGGGTTATTGGAAAACACCTCGTGGCAAAAGATAATATTGCTACTGGTTTTATCGCGCGTTGTATCAAAGAAAATTTTTAAAATATACTCTCTTTCTAAATATTCTTTGGCTCCCAGCTCTTTGCACAGATCACGGGTATTTTCCGTGAGAGCACAAATCATTCCATAGTTAATATCTGCACCCCATTCAGTAAACAGCTTTATCAAGTCATGATTATTCTCCTTCACGGCTTTCATCAGTCCTATGTTTAACTCGATACCTTGACTAAAACAGGTTGACCTTATAAATAATTTATTGCGTCGAATATGAAGCATAATGGGGCCATTATGCCACCACAGGCCACAACACTTCAGGACATGATATTGATCTACCGGTATACACTGCCCGGCCAGTACTTTCTTCGTGAGGGATTGCAGGGAAGGCAACAT
SEQ ID No.26–格鲁吉亚2007/1MGF 360 11L(NC_044959.1:26465-27526)
TTATCTTTGTTCATAATCAAGAAAAATCCCCATATTTATTGAGTGATAATTTTTTAACATGCAATTTATTTTTTCAGGGTCCGTAACGATCGACAACAGAGAAATAACCGGATTGTAATGCTTTAATGATAAGGCATGGGCTATCAGATAATTTTCCTTTTGTTCTGCCAAAGCTTTGCCCTCCTCAAAGGCATCGGCACCCAGGTCTATACAAAAGAACAGGTTTCCAAGATTATAGTTTTGTATGGAAACAAGCATGGCTTGATTGATGTTGGCTCCCATGATAAAACAGTAGTAAATGGCCGAATAGCTATAATCTTGGATGCAGGCTATGTGCATCATTTCATCAATATCCATGCGGACCCTTTCTATTTCGTACAGCTCGTGAAGGTCGAACACGTTGTTGTAAAAAAGGGCGCACATGAGCCGCCACCTATGTAGACGCGGGTATTTCTGGTAAAAGTAGCGGATAGCATCTTTGAGGTCATAGTCCACCGCTATCGCGTACCAGTATTTGGTTAAAACAGTGCTAAAGCTATCATCATGGTCCAGCATGAAGGTTATCTCCATGAGCCCTCTTAACTCCCACATGATTTCCCCCCTCAGATCCAGATTATCTATAATCCTTAAATTGGGGTTATTGGAAAACACCTCGTGGCAAAAGATAATATTGCTACTGGTTTTATCGCGCGTTGTATCAAAGAAAATTTTTAAAATATACTCTCTTTCTAAATATTCTTTGGCTCCCAGCTCTTTGCACAGATCACGGGTATTTTCCGTGAGAGCACAAATCATTCCATAGTTAATATCTGCACCCCATTCAGTAAACAGCTTTATCAAGTCATGATTATTCTCCTTCACGGCTTTCATCAGTCCTATGTTTAACTCGATACCTTGACTAAAACAGGTTGACCTTATAAATAATTTATTGCGTCGAATATGAAGCATAATGGGGCCATTATGCCACCACAGGCCACAACACTTCAGGACATGATATTGATCTACCGGTATACACTGCCCGGCCAGTACTTTCTTCGTGAGGGATTGCAGGGAAGGCAACAT
SEQ ID No.27–L60 MGF 360 11L(NC_044941.1:21052-22113)
TTATCTTTGTTCATAATCAAGAAAAATCCCCATATTTATTGAGTGATAATTTTTTAACATGTAATTTATTTTTTCAGGGTCCATAACGTTCGACAACAGAGAAATGACTGGATTGTAATGCTTTAATGATAAGGCATGGGCTATCAGATAATTTTCCTTTTGTTCTGCCAAAGCTTTGCCCTCCTCAAAGGCGTTGGCGCCCAGGTCTATACAAAAGAACAGGTTTCCAAGATTATAGTTTTGTATGGAAACCAGCATGGCTTGATTGATGTTGGCTCCCATGATAAAACAGTAGTAAATGGCCGAATAGCTATAATCTTGGATGCAGGCTATGTGCATCATTTCATCGATATCCATGCGGACCCTTTCTATTTCATACAGCTCGTGAAGGTCGAACACGTTGTTGTAAAAAAGGGCGCACATGAGCCGCCACCGATGTAGGCGCGGGTATTTCTGGTAAAAGTAGCGAATAGCATCTTTGAGGTCATAGTCCACCGCTATAGCATACCAGTATTTGGTTAAAACAGTGCTAAAGCTATCATCATGGTCTAGCATGAAGGTTATCTCCATGAGCCCTCTTAACTCCCACATGATTTCCCCCCTCAGATCCAGATTATCTATAATCCTTAAATTGGGGTTATTGGAAAACACCTCGTGGCAAAAGATAATATTGCTACTGGTTTTATCGCGCGTCGTATCAAAGAAAATTTTTAAAATATACTCTCTTTCTAAATATTCTTTGGCTCCCAGCTCTTTGCACAGATCACGGGTATTTTCCGTGAGAGCACAAATCATTCCATAGTTAATATCTGCACCCCATTCAGTAAACAGCTTTATCAAGTCATGATTATTCTCCTTCACGGCTTTCATCAGTCCTATGTTTAACTCGATACCTTGACTAAAGCAGGTTGACCTTATAAATAGTTTATTACGTCGAATATGAAGCATAATGGGGCCATTATGCCACCACAGGCCACAACACTTCAGGATATGATAATGATCCACCGACACGCACTGCCCGGCCAGTACTTTCTTCGTGAGGGATTGCAGGGAAGGCAACAT
SEQ ID No.28–Ken05/Tk1 MGF 360 11L(NC_044945.1:28407-29468)
TTATCTGCGTTCATAATCGAGAAAAACCACCATATTCTTTGAGTGATAATTTTTTAACATAGAATTTATCTTTTCTGGGTCGGTCACGGCCGACAACAGGGAAATCACCGGGTTATAATGTTTTAATGATAAGGCATCGGCTATCAAATAATTTTCCTTTTGTATTGCTAGGGCTTTGCCTTCTTCAAAGGCGTTGGCACCCAGGTCTATACAAAAGAACATGTTCCCGAGATTATAGTTTTGTATGGAAACAAACATGGCTTGATTGATGTTGGCCCCCATGATAAAACAGTAGTAAATAGCTGAATAGCTATAATCTTGGATGCAGGCTATGTGCATCATCTCATCGATATCCATGCGGACCCTTTCTATTTCATACAGCTCGTGAAGGTCGAACACATTGTTATAAAAAAGGGCGCACATAAGCCGCCACCGATGTAGATGGGTATACTTCTGATAAAAATAGTGGATGGCCTTTTTGAGGCCGTAGTCTACCGCTATGGCGTACCAGTATTTGGTTAACATATTGCTGAAGGAGTTGTCATGGTCCAACATGTAGGTTATTTCCATGAGTCCCCTTAGCTCCCACATGATTTCCTCCCTCAGATCCAAATCATCCACATGTTTCAGATTGGCGTTATTGGAAAACATTTCGTGGCATAAGATAATATTACTGTCGGTTTTGTTGCGCGTCGTATCAAAGAAAATTTTTAAAATATACTCTCTATCTAAACGGTCTTTGGCTCCAAGTTCTCTACATAGATTGCGGGTGTGCTCCGAATGAGCACAAACCAGTCCATAATTAATATCGGCACCCCACTCAACAAACAGCCTTATCAAGTCATGATTGTTTTCCTTCGCGGCTTTCATCAGTACGGTGTTCAATTCAATACCCTCGCTAAAACAGGTTGACTTTATAAACATTTTGTTACGATACGTATAAAATGTAATAGGGCCATCATACCACCACAACCCGCAGCATTTCAGGATATGATATTGATCTACCGGTATACACTGTTTGGCCAGCACTTTCTTGGATAGGGATTGCAAGGAAGGCAACAT
SEQ ID No.29–Ken06.Bus MGF 360 11L(NC_044946.1:24534-25595)
TTATCTGCGTTCATAATCGAGAAAAACCACCATATTCTTTGAGTGATAATTTTTTAACATAGAATTTATCTTTTCCGGGTCGGTCACGGCCGACAACAGGGAAATCACCGGGTTATAATGTTTTAATGATAAGGCATCGGCTATCAAATAATTTTCCTTTTGTATTGCTAGGGCTTTGCCTTCTTCAAAGGCGTTGGCACCCAGGTCTATACAAAAGAACATGTTCCCGAGATTATAGTTTTGTATGGAAACAAACATGGCTTGATTGATGTTGGCACCCATGATAAAACAGTAGTAAATAGTTGAATAGCTATAATCTTGGATGCAGGCTATGTGCATCATCTCATCGATATCCATGCGGATCCTTTCTATTTCATACAGCTCGTGAAGGTCGAACACATTGTTATAAAAAAGGGCGCACATGAGCCGCCACCGATGTAGATGGGTATACTTCTGATAAAAATAGTGGATGGCCTTTTTGAGGCCGTAGTCTACCGCTATGGCGTACCAGTATTTGGTTAACATGTTGCTGAAGGAGTTGTCATGGTCCAACATGTAGGTTATCTCCATGAGTCCCCTTAGCTCCCACATGATTTCCTCCCTCAGGTCCAAATCATCCACATGTTTCAGATTGGGGTTATTGGAAAACATTTCGTGGCATAAGATAATATTACTGTCGGTTTTGTTGCGCGTCGTATCAAAGAAAATTTTTAAAATATACTCTTTATCTAAACGGTCTTTGGCCCCTAGTTCTCTGCATAGATCGCGGGTGTGCTCCGAATGAGCACAAACCAGTCCATAATTAATATCGGCACCCCACTCAGTAAATAATTTTATTAGGTCATGATTGTTTTCCTTCGCGGCTTTCATCAGTACGGTGTTCAATTCAATACCCTCGCTAAAACAGGTTGACTTTATAAACATTTTGTTACGATACGTATAAAATGTAATAGGGCCATCATACCACCACAACCCGCAACTTTTCAGGATATGATATTGATCTACCGGTATACACTGTTTGGCCAGCACTTTTTTGGATAGGGATTGCAAGGAAGGCAACAT
SEQ ID No.30–肯尼亚1950MGF 360 11L(AY261360.1:30655-31716)
TTATCTGCGTTCATAATCGAGAAAAACCACCATATTCTTTGAGTGATAATTTTTTAACATAGAATTTATCTTTTCTGGGTCGGTCACGGCCGACAACAGGGAAATCACCGGGTTATAATGTTTTAATGATAAGGCATCGGCTATCAAATAATTTTCCTTTTGTATTGCTAGGGTTTTGCCTTCTTCAAAGGCGTTGGCACCCAGGTCTATACAAAAGAACATGTTCCCGAGATTATAGTTTTGTATGGAAACAAACATGGCTTGATTGATGTTGGCCCCCATGATAAAACAGTAGTAGATAGCTGAATAGCTATAATCTTGGATGCAGGCTATGTGCATCATCTCATCGATATCCATGCGGACCCTTTCTATTTCATACAGCTCGTGAAGGTCGAACACATTGTTATAAAAAAGGGCGCACATAAGCCGCCACCGATGTAGATGGGTATACTTCTGATAAAAATAGTGGATGGCCTTTTTGAGGCCGTAGTCTACCGCTATGGCGTACCAGTATTTGGTTAACATATTGCTGAAGGAGTTGTCATGGTCCAACATGTAGGTTATCTCCATGAGTCCCCTTAGCTCCCACATGATTTCCTCCCTCAGATCCAAATCATCCACATGTTTCAGATTGGGGTTATTGGAAAACATTTCGTGGCATAAGATAATATTACTGTCGGTTTTGTTGCGCGTCGTATCAAAGAAAATTTTTAAAATATACTCTCTATCTAAACGGTCTTTGGCTCCAAGTTCTCTGCATAGATTGCGGGTGTGCTCCGAATGAGCACAAACCAGTCCATAATTAATATCGGCACCCCACTCAACAAACAGCCTTATCAAGTCATGATTGTTTTCCTTCGCGGCTTTCATCAGTACGGTGTTCAATTCAATACCCTCGCTAAAACAGGTTGACTTTATAAACATTTTGTTACGATACGTATAAAATGTAATAGGGCCATCATACCACCACAACCCGCAGCATTTCAGGATATGATATTGATCTACCGGTATACACTGTTTGGCCAGCACTTTCTTGGATAGGGATTGCAAGGAAGGCAACAT
SEQ ID No.31–马拉维Lil-20/1(1983)MGF 360 11L(AY261361.1:24831-25892)
TTATCTTCGTTCATAATCAAGAAAAACCCTCATATTTATTGAGTGATAATTTTTTAACATGCAATTTATTTTTTCAGGGTCCATAATGACCGACAACAGAGAAATGACCGGATTGTAATGCTTTAATGATAAGGCATCGGCTATCAGATAATTTTCCTTTTGTTCTGCCAAAGCTTTCCCCTCCTCAAAGGCGTTGGCCCCCAGATCTATACAAAAGAACATGTTCCCAAGATTATAGTTTTGTATAGAAACAAGCATGGCTTGATTGATGTTGGCCCCCATGATAAAACAGTAATAAATAGCCGCATAGCTATAATCTTGGACGCAGGCTATGTGCATCATTTCATCAATATCCATGCGGACCCTTTCTATTACATACAGCTCGTGAAGGTCGAACACGTTGTTGTAAAAAAGGGCGCACATAAGCCGCCAGTGGTGTAGATGGGTATACCTCTGATAAAAATAATGGATAGCCTTTTTGAGGCCATAGTCTACCGCTATGGCGTACCAGTATTTGGTTAACATATTGCTAAAGGAGTTGTCATGGTCCAACATGTAGGTTATCTCCATGAGTCCCCTTAGCTCCCACATGATTTCCTCCCTCAGATCCAAATTATCCACATTTTTCAGGTTGGGGTTATTGGAAAACATTTCGTGGCATAAGATAATATTACTGTCGGTTTTGTTGCGCGTCGTATCAAAGAAAATTTTTAAAATATAATCTCTATCTAAACGATCTTTGGCTCCTAGTTCTCTGCATAGATTACGGGTGTGCTCCGTATGGGCACAAATCAGTCCATAATTAATATCGGCACCCCACTCGGCAAACAGCCTTATCAAGTCATGGTTGTTTTCCTTCGCGGCTTTCATCAGTACGGTGTTCAATTCAATACCCTCGCTAAAACAGGTTGACCTTATAAACATTTTGTGACGATAAACGTAAAATGTAATAGGGCCATCATACCACCACAACCCGCAGCACTTTAAGACATGATATTGATCTACCGGTACACACTGTTTGGCCAGCACTTTCTTAGTTAAAGATTGTAAGGAAGGCAACAT
SEQ ID No.32–Mkuzi 1979MGF 360 11L(AY261362.1:28164-29225)
TTATCTTTGTTCATAATCAAGAAAAATCCCCATATTTATTGAGTGATAATTTTTTAACATGTAATTTATTTTTTCAGGGTCCATAACGATCGACAACAGAGAAATGACCGGATTGTAATGCTTTAATGATAAGGCATGGGCTATCAGATAATTTCCCTTTTGTTCTGCCAAAGCTTTGCCCTCCTCAAAGGCGTTGGCGCCCAGGTCTATACAAAAGAACAGGTTTCCAAGATTATAGTTTTGTATGGAAACCAGCATAGCTTGATTGATGTTGGCTCCCATGATAAAACAGTAGTAAATGACCGAATAGCTATAATCTTGGATGCAGGCTATGTGCATCATTTCATCAATATCCATGCGGACCCTTTCTATTTCATACAGCTCGTGAAGGTCGAACACGTTGTTGTAAAAAAGGGCGCACATGAGCCGCCACCTATGTAGGCGCGGGTATTTCTGGTAAAAGTAGCGAATAGCATCTTTGAGGTCATAGTCCACCGCTATAGCATACCAGTATTTGGTTAAAACAGTGCTAAAGCTATCATCATGGTCTAGCATGAAGGTTATCTCCATGAGCCCTCTTAACTCCCACATGATTTCTCCCCTCAGATCCAGATTATCTATAATCCTTAAATTGGGGTTATTGGAAAACACCTCGTGGCAAAAGATAATATTGCTACTGGTTTTATCGCGCGTCGTATCAAAGAAAATTTTTAAAATATACTCTCTTTCTAAATATTCTTTGGCTCCCAGCTCTTTGCACAGATCACGGGTATTTTCCGTGAGAGCACAAATCATTCCATAGTTAATATCTGCACCCCATTCAGTAAACAGCTTTATCAAGTCATGATTATTCTCCTTCACGGCTTTCATCAGTCCTATGTTTAACTCGATACCTTGACTAAAGCAGGTTGACCTTATAAATAGTTTATTACGTCGAATATGAAGCATAATGGGGCCATTATGCCACCACAGGCCACAACACTTCAGGATATGATAATGATCCACCGACACGCACTGCCCGGCCAGTACTTTCTTCGTGAGGGATTGCAGGGAAGGCAACAT
SEQ ID No.33–Pretorisuskop/96/4MGF 360 11L(AY261363.1:27214-28275)
TTATCTTTGTTCATAATCAAGAAAAATCCCCATATTTATTGAGTGATAATTTTTTAACATGCGATTTATTTTTTCAGGGTCCGTAACCACCGACAACAGAGAAATGACCGGATTGTAATGCTTTAATGATAAGGCATTGGCTATCAGATAATTTCCCTTTTGTTCTGCCAAAGCTTTGCCCTCTTCAAAGGCGTTGGCACCCAGGTCTATACAAAAGAACAGGTTCCCAAGATTATAGTTTTGTATGGAAACCAGCATGGCTTGATTGATGTTGGCTCCCATGATAAAACAGTAGTAAATGGCTGAATAGCTATAATCTTGGACGCAGGCTATGTGCATCATTTCATCAATGTCCATGCGGACCCTTTCTATTTCATACAGCTCGTGAAGGTCGAACACGTTGTTGTAAAAAAGGGCGCACATGAGCCGCCACCTATGTAGCCGCGGGTATTTCTGGTAAAAGTAGCGGATAGCATCTTTGAGGTCATAGTCCACCGCTATCGCGTACCAGTATTTGGTTAAAACAGTGCTAAAGCTATCATCATGGTCCAGCATGAAGGTTATCTCCATGAGCCCTCTTAACTCCCACATGATTTCCCCCCTCAGATCCAGATTATCTATAATCCTTAAATTGGGGTTATTGGAAAACACCTCGTGGCAAAAGATAATATTGTTACTGGTTTTATCGCGCGTTGTATCAAAGAAAATTTTTAAAATATACTCTCTTTCTAAATATTCTTTGGCTCCCAGCTCTTTGCACAGATCACGGGTATTTTCCGTGAGAGCACAAATCATTCCATAGTTAATATCTGCACCCCATTCAGTAAACAGCTTTATCAAGTCATGATTATTCTCCTTCACGGCTTTCATCAGTCCTATGTTTAACTCGATACCTTGACTAAAGCAGGTTGACCTTATAAATATTCTATTACGTCGAATATGAAGCATTATGGGGCCATTATGCCACCACAGGCCACAACACTTCAGGATATGATAATGATCTACCGACACGCACTGCCCAGCCAGTACTTTCTTCGTGAGGGATTGCAGGGAAGGCAACAT
SEQ ID No.34–Tengani 62MGF 360 11L(AY261364.1:21627-22688)
TTATCTTTGTTCATAATCAAGAAAAATCCCCATATTTATTGAGTGATAATTTTTTAACATGCAATTTATTTTTTTAGGGTCTGTAACGACCGACAACAGAGAAATGACCGGATTGTAATGCTTTAATGATAAGGCATCGGCTATCAGATAATTTCCCTTTTGTTCTGCCAAAGCTTTGCCTTCCTCAAAGGCGTTGGCTCCCAGGTCTATACAAAAGAACAGGTTCCCAAGATTATAGTTTTGTATGGAAACCAGCATGGCTTGATTGATGTTGGCTCCCATGATAAAACAGTAGTAAATGGCCGAATAGCTATAATCTTGGACGCAGGCTATGTGCATCATTTCATCAATGTCCATGCGGACCCTTTCTATTTCGTACAGCTCGTGAAGGTCGAACACGTTGTTGTAAAAAAGGGCGCACATGAGCCGCCACCTATGTAGACGCGGGTATTTCTGGTAAAAGTAGCGGATCGCATCTTTGAGGTCATAGTCCACCGCTATCGCGTACCAGTATTTGGTTAAAACAGTGCTAAAGCTATCATCATGGTCCAGCATGAAGGTTATCTCCATGAGCCCTCTTAACTCCCACATGATTTCCCCCCTCAGATCCAGATTATCTATAATCCTTAAATTGGGGTTATTGGAAAACACCTCGTGGCAAAAGATAATATTGTTACTGGTTTTATCGCGCGTCGTATCAAAGAAAATTTTTAAAATATACTCTCTTTCTAAATATTCTTTGGCACCCAGCTCTTTGCACAGATCACGGGTATTTTCCGTGAGAGCACAAATCATTCCATAGTTAATATCTGCACCCCATTCAGTAAACAGCTTTATCAAGTCATGATTATTCTCCTTCACGGCTTTCATCAGTCCTATGTTTAACTCGATACCTTGACTAAAGCAGGTTGACCTTATAAATAGTTTATTACGTCGAATCTGAAGCATAATGGGTCCATTATGCCACCACAGGCCACAACACTTCAGGATATGATAATGATCCACCGACACGCACTGCCCGGCCAGTACTTTCTTCGTGAGGGATTGCAGGGAAGGCAACAT
SEQ ID No.35–Warmbaths MGF 360 11L(AY261365.1:26388-27449)
TTATCTTTGTTCATAATCAAGAAAAATCCCCATATTTATTGAGTGATAATTTTTTAACATGCGATTTATTTTTTCAGGGTCCGTAACCACCGACAACAGAGAAATGACCGGATTGTAATGCTTTAATGATAAGGCATTGGCTATCAGATAATTTCCCTTTTGTTCTGCCAAAGCTTTGCCCTCCTCAAAGGCGTTGGCACCCAGGTCTATACAAAAGAACAGGTTCCCAAGATTATAGTTTTGTATGGAAACCAGCATGGCTTGATTGATGTTGGCTCCCATGATAAAACAGTAGTAGATGGCTGAATAGCTATAATCTTGGACGCAGGCTATGTGCATCATTTCATCAATGTCCATGCGGACCCTTTCTATTTCATACAGCTCGTGAAGGTCGAACACGTTGTTGTAAAAAAGGGCGCACATGAGCCGCCACCTATGTAGCCGCGGGTATTTCTGGTAAAAGTAGCGGATAGCATCTTTGAGGTCATAGTCCACCGCTATCGCGTACCAGTATTTGGTTAAAACAGTGCTAAAGCTATCATCATGGTCCAGCATGAAGGTTATCTCCATGAGCCCTCTTAACTCCCACATGATTTCCCCCCTCAGATCCAGATTATCTATAATCCTTAAATTGGGGTTATTGGAAAACACCTCGTGGCAAAAGATAATATTGTTACTGGTTTTATCGCGCGTTGTATCAAAGAAAATTTTTAAAATATACTCTCTTTCTAAATATTCTTTGGCTCCCAGCTCTTTGCACAGATCACGGGTATTTTCCGTGAGAGCACAAATCATTCCATAGTTAATATCTGCACCCCATTCAGTAAACAGCTTTATCAAGTCATGATTATTCTCCTTCACGGCTTTCATCAGTCCTATGTTTAACTCGATACCTTGACTAAAGCAGGTTGACCTTATAAATATTCTATTACGTCGAATATGAAGCATTATGGGGCCATTATGCCACCACAGGCCACAACACTTCAGGATATGATAATGATCCACCGACACGCACTGCCCGGCCAGTACTTTCTTCGTGAGGGATTGCAGGGAAGGCAACAT
SEQ ID No.36–Warthog MGF 360 11L(AY261366.1:23157-24218)
TTATCTTTGTTCATAATCAAGAAAAATCCCCATATTTATTGAGTGATAATTTTTTAACATGCGATTTATTTTTTCAGGGTCCGTAACCACCGACAACAGAGAAATGACCGGATTGTAATGCTTTAATGATAAGGCATTGGCTATCAGATAATTTCCCTTTTGTTCTGCCAAAGCTTTGCCCTCCTCAAAGGCGTTGGCCCCCAGGTCTATACAAAAGAACAGGTTCCCAAGATTATAGTTTTGTATGGAAACCAGCATGGCTTGATTGATGTTGGCTCCCATGATAAAACAGTAGTAAATGGCTGAATAGCTATAATCTTGGACGCAGGCTATGTGCATCATTTCATCAATGTCCATGCGGACCCTTTCTATTTCATACAGCTCGTGAAGGTCGAACACGTTGTTGTAAAAAAGAGCGCACATGAGCCGCCACCTATGTAGCCGCGGGTATTTCTGGTAAAAGTAGCGGATAGCATCTTTGAGGTCATAGTCCACCGCTATCGCGTACCAGTATTTGGTTAAAACAGTACTAAAGCTATCATCATGGTCCAGCATGAAGGTTATCTCCATGAGCCCTCTTAACTCCCACATGATTTCTCCCCTTAGATCCAGATTATCTATAATCCTTAAATTGGGGTTATTGGAAAACACCTCGTGGCAAAAGATAATATTGTTACTGGTTTTATCGCGCGTTGTATCAAAGAAAATTTTTAAAATATACTCTCTTTCTAAATATTCTTTGGCTCCCAGCTCTTTGCACAGATCACGGGTATTTTCCGTGAGAGCACAAATCATTCCATAGTTAATATCTGCACCCCATTCAGTAAACAGCTTTATCAAGTCATGATTATTCTCCTTCACGGCTTTCATCAGTCCTATGTTTAACTCGATACCTTGACTAAAGCAGGTTGACCTTATAAATATTCTATTACGTCGAATATGAAGCATTATGGGGCCATTATGCCACCACAGGCCACAACACTTCAGGATATGATAATGATCCACCGATACGCACTGCCCGGCCAGTACTTTCTTCGTGAGGGATTGCAGGGAAGGCAACAT
在实施方案中，本发明的减毒ASFV包含MGF 360 11L的功能形式。适当地，MGF 36011L的功能形式包含SEQ ID No.24、25、26、27、28、29、30、31、32、33、34、35或36的序列。适当地，MGF 360 11L的功能形式包含与SEQ ID No.24、25、26、27、28、29、30、31、32、33、34、35或36具有至少70％、至少80％、至少90％或至少95％的同一性的序列。适当地，MGF 360 11L的功能形式由SEQ ID No.24、25、26、27、28、29、30、31、32、33、34、35或36的序列组成。
MGF 360 12L基因序列
SEQ ID No.37–贝宁97/1MGF 360 12L(NC_044956.1:23616-24668)
TCATCTTAAATCATAGGAAAGGAAGATCATCATATTTTTTGAAAAGTAATTTTTTAACGCATGATCTATGATTTCAGGGTCCGTGCTTTTAGGCAACGGGATGGTGGTCGGACTATAAATCTTTAGAGATAAAATGTTTTTTATAAGCTCATACCCTTCCCCTAAAGCTGTAGTACCCTCTTCGAAAACATCAGCCCCCAGATCCATACAAAAGAACATGTTTTCTATATTATAGTACTGTATTGAGGTAAGCATGGCCTGATTGATGTTGGCGCCCAACATATAGCAGTAGTACATGGTTGAAAGGTTGTGGTCTTTGATGCAGGCAATCCGCATCATCTCTTCTATGTCCATATGGATCTTGTCCTTTTCATACGCCTCATGGAGGTCAAACACATTATTAAAACAAAGAGCACATGTTAACCGCCACGTATTCATGTGTGTATATTTTTGGTAAAAATACTGTATGGCCTCTTTCAGGCTATAGCGTACGGCTATAGCGTACCAGTATTTGAGTAGTAATGTACTGAGCAAAAACTCATTATTTAGCAGATCGGTTTTTTCTATTAACTCCCTTAACTCCCAGAAAATTTCTATCCTCAATTTCAGATTATTTACTTTTTGTAATATCGGATTGTTGGAAAACACCTCATGGCATAAAATAATGTTACTACTAGTTTTATGAAACTTTAGATCTATGAAAATTTGTAAAATTTCCTCTTCATTCAAGATCTCCTTGGCACCTAACTCTTGACAGAGGTCCCGGGTATGCTCCGTGTTGACAGATACCAGCCCATAGTTGATGTCCGCCCCCCACTCTGTAAATAGTTTTATAAGGCTGTAGTTGTTTTCCCTTACAGCCTTTACTAACGCCGTATTTAGGTCTAAGCCCTCTTTAATGCCTGATGATTTTATGAGCCTTAGGTTATGATCAAACGTGATCGGAGCATTATACCACCATAGATCATAATATTTTAAAAGATAATGTTGGTTCGTGGGCACGCATTGTCCAGCCAACACCTTTTTGGTCAAAGATTGCAGGGAAGGCAACAT
SEQ ID No.38–中国/2018/安徽XCGQ MGF 360 12L(MK128995.1:29384-30436)
TCATCTTAAATCATAGGTAAGGAAGATCATCATATTTTTTGAAACGTAATTTTTTAACGCATGATCTATGATTTCAGGGTCCGTGCTTTTAGGCAACGGGGTGGTGGCCGGACTATAAATCTTTAGGGATAAAATGTTCTTTATAAGCTCATACCCTTCCCCTAAAGCTGTAGTACCCTCTTCGAAAACATCAGCCCCCAGATCTATACAAAAGAACATGTTTTCTATATTATAGTACTGTATTGAGCTAAGCATGGCTTGATTGATGTTGGCGCCCAGGACATAGCAGTAGTACATGGTTGAAAGGTTGTGGTCTTTGATGCAGGCGATCCGCATCATCTCTTCTATGTCCATATGGATCTTGTCCTTTTCATACGCCTCATGAAGGTCAAACACATTATTAAAACAAAGAGCACATGTTAACCGCCACGTATTCAGGTGTGTATATTTTTGGTAAAAATACTGTATGGCCTCTTTCAGGTTATAGCGTATGGCTATAGCGTACCAGTATTTGAGTAGTAATGTACTGAGCGAAAACTCATTATTTAGCAGATCGGTTTTTACTATTAACTCCCTTAACTCCCAGAAAATTTCTATCCTCATTTTTATATTATTTACTTTTTGTAATATCGGATTGTTGGAAAACACCTCATGGCATAAAATAATGTTACTACTAGTTTTATGAAACTTTAGATCTATAAAAATTTGTAAAATTTCTTCTTCATTCAAGGTTTCCTTGGCACCTAGCTCTCGACAGAGGTCCCAGGTGTGCTCCGTGTTGACAGATACCAGCCCGTAGTTGATGTCCGCCCCCCACTCTGCAAACAGTTTTATAAGGTTGTAGTTGTTTTCCCTTACAGCCTTCACTAACGCCGTATTTAGGTTTAAGCCCTCTTTAATACCTGCTGATTTTATGAGCCTTAGGTTATGATCAAACGTGATCGGAGCATCATGCCACCATAGGTCATAACACTTTAAAAGATAATGTTGGTTCGTGGGCACGCATTGTCCAGCCAACACCTTTTTGGTCAGAGATTGCAGGGAAGGCAACAT
SEQ ID No.39–格鲁吉亚2007/1MGF 360 12L(LR743116.1:30355-31407)
TCATCTTAAATCATAGGTAAGGAAGATCATCATATTTTTTGAAACGTAATTTTTTAACGCATGATCTATGATTTCAGGGTCCGTGCTTTTAGGCAACGGGGTGGTGGCCGGACTATAAATCTTTAGGGATAAAATGTTCTTTATAAGCTCATACCCTTCCCCTAAAGCTGTAGTACCCTCTTCGAAAACATCAGCCCCCAGATCTATACAAAAGAACATGTTTTCTATATTATAGTACTGTATTGAGCTAAGCATGGCTTGATTGATGTTGGCGCCCAGGACATAGCAGTAGTACATGGTTGAAAGGTTGTGGTCTTTGATGCAGGCGATCCGCATCATCTCTTCTATGTCCATATGGATCTTGTCCTTTTCATACGCCTCATGAAGGTCAAACACATTATTAAAACAAAGAGCACATGTTAACCGCCACGTATTCAGGTGTGTATATTTTTGGTAAAAATACTGTATGGCCTCTTTCAGGTTATAGCGTATGGCTATAGCGTACCAGTATTTGAGTAGTAATGTACTGAGCGAAAACTCATTATTTAGCAGATCGGTTTTTACTATTAACTCCCTTAACTCCCAGAAAATTTCTATCCTCATTTTTATATTATTTACTTTTTGTAATATCGGATTGTTGGAAAACACCTCATGGCATAAAATAATGTTACTACTAGTTTTATGAAACTTTAGATCTATAAAAATTTGTAAAATTTCTTCTTCATTCAAGGTTTCCTTGGCACCTAGCTCTCGACAGAGGTCCCAGGTGTGCTCCGTGTTGACAGATACCAGCCCGTAGTTGATGTCCGCCCCCCACTCTGCAAACAGTTTTATAAGGTTGTAGTTGTTTTCCCTTACAGCCTTCACTAACGCCGTATTTAGGTTTAAGCCCTCTTTAATACCTGCTGATTTTATGAGCCTTAGGTTATGATCAAACGTGATCGGAGCATCATGCCACCATAGGTCATAACACTTTAAAAGATAATGTTGGTTCGTGGGCACGCATTGTCCAGCCAACACCTTTTTGGTCAGAGATTGCAGGGAAGGCAACAT
SEQ ID No.40–Ken06.Bus MGF 360 12L(NC_044946.1:27428-28483)
TCATCTTAGATCATAAGTAAGGAAGACCATCATATTTTTTGAAAAGTAATTTTTTAACGCATGATCTATAATTTCAGGGTCCGTGCTTTTAGGCAATGGGGTAGTGGCCGGGCTATAAATCTTTAGGGATAAAATATTCCTTATAGGCTCATACCCTTCCTGTCCCACTAGAGCCATACCCTCTTCAAAAGCATCGGCCCCCAGATCCATACAAAAGAATATGTTTTCTATATTATAGTACTGTATTGAGGTAAGCATGGCCTGATTGATGTTGGCGCCCAGCATATAGCAGTAGTATATTGTTGAAAGGTTGTGGTCTTTGATGCAGGCTATCCGCATCATCTCTTCTAAATCCATACAGATCTTGTCCTTTTCATACGCCTCATGAAGGTCAAACACGTTATTAAAACAAAGAGCACATGTTAACCGCCACGTATTCAGGTGTGTATATTTTTGGTAAAAATACTGTATGGCCTCTTTCAAGTTGTAGCGTACGGCTATAGCGTACCAGTATTTGAGTAATAGTGTATTGAGCGAAAACTCATTATTTAGCAGATCGGTTTTTTCTATTATCTCCCTTAACTCCCAAAAAATTTCTATCCTCATTTTCAGGTTATTTACCCTTTTTAAAAGTAAATTATCGGAAAACACCTCATGACATAAGATAATGTTACTACTGGTTTTATAAAATTTTAAATCTATGAAAATTTGTAAAATATCCCCTTCATTTAAGGTCTTCTTGGCGCCTAGCTCTCGACAGAGGTCCCAGGTGTGCTCCGTGTTGACAGATATCAGCCCGTAGTTAATGTTCGCCCCCCACTCCGTAAATAGTTTTATAAGACTGTAGTTGTTTTCCTTTACAGCCTTCACTAATGCCATGTTTAGGTCTAAGCCTTCTTGAATGCCTGCTAATTTTATCAGCCTTAGGTTATGATCAAACGTGATCGGAGCATTATTCCACCATAGATCGTAACACTTTAAAAGATAATGTTGGTCCTCGGGCAGACATTGTCTAGCCAGCACCTTTTTGGTCAAAGATTGCAGGGAAGGCAACAT
SEQ ID No.41–肯尼亚1950MGF 360 12L(AY261360.1:33549-34604)
TCATCTTAGATCATAAGTAAGGAAGACCATCATATTTTTTGAAAAGTAATTTTTTAACTCATGATCTATAATTTCAGGGTCCGTGCTTTTAGGCAACGGGGTGGTGGCCGGGCTATAAATCTTTAGGGATAAAATATTCCTTATAGGCTCATACCCTTCCTGTCCCACTAGAGCCATACCCTCTTCAAAAGCATCGGCCCCCAGATCCATACAAAAGAATATGTTTTCTATATTATAGTACTGTATTGAGGTAAGCATGGCCTGATTGATGTTGGCGCCCAGCATATAGCAGTAGTATATCGTTGAAAGGCTGTGGTCTTTGATGCAGGCTATCCGCATCATCTCTTCTAAATCCATACAGATCTTGTCCTTTTCATACGCCTCATGAAGGTCAAACACGTTATTAAAACAAAGAGCACATGTTAATCGCCACGTATTCAGGTGCGTATATTTTTGGTAAAAATACTGTATGGCCTCTTTCAAGTTGTAGCGTACGGCTATAGCGTACCAGTATTTGAGTAATAGTGTATTGAGCGAAAACTCATTATTTAGCAGATCGGTTTTTTCTATTATCTCCCTTAACTCCCAAAAAATTTCTATCCTCATTTTCAGGTTATTTACCTTTTTTAAAAGTAGATTATCGGAAAACACCTCATGACATAAGATAATGTTACTACTGGTTTTATGAAACTTTAAATCTATGAAAATTTGTAAAATATCCCCTTCATTTAAGGTCTTCTTGGCGCCTAGCTCTCGACAGAGGTCCCAGGTGTGCTCCGTGTTGACAGATATCAGCCCGTAGTTGATGTTCGCTCCCCACTCCGTAAATAGTTTTATAAGACTGTAGTTGTTTTCCTTTACAGCCTTCACTAATGCCATGTTTAGGTCTAAGCCTTCTTGAAGGCCTGCTGATTTTATCAGCCTTAGGTTATGATCAAACGTGATCGGAGCATTATTCCACCATAGATCGTAACACTTTAAAAGATAATGTTGGTCCTCGGGCAGACATTGTCCAGCCAGCACCTTTTTGGTCAGAGATTGCAGGGAAGGCAACAT
SEQ ID No.42–L60 MGF 360 12L(NC_044941.1:23965-25017)
TCATCTTAAATCATAGGAAAGGAAGATCATCATATTTTTTGAAAAGTAATTTTTTAACGCATGATCTATGATTTCAGGGTCCGTGCTTTTAGGCAACGGGATGGTGGTCGGACTATAAATCTTTAGAGATAAAATGTTTTTTATAAGCTCATACCCTTCCCCTAAAGCTGTAGTACCCTCTTCGAAAACATCAGCCCCCAGATCCATACAAAAGAACATGTTTTCTATATTATAGTACTGTATTGAGGTAAGCATGGCCTGATTGATGTTGGCGCCCAACATATAGCAGTAGTACATGGTTGAAAGGTTGTGGTCTTTGATGCAGGCAATCCGCATCATCTCTTCTATGTCCATATGGATCTTGTCCTTTTCATACGCCTCATGGAGGTCAAACACATTATTAAAACAAAGAGCACATGTTAACCGCCACGTATTCAGGTGTGTATATTTTTGGTAAAAATACTGTATGGCCTCTTTCAGGCTATAGCGTACGGCTATAGCGTACCAGTATTTGAGTAGTAATGTACTGAGCAAAAACTCATTATTTAGCAGATCGGTTTTTTCTATTAACTCCCTTAACTCCCAGAAAATTTCTATCCTCAATTTCAGATTATTTACTTTTTGTAATATCGGATTGTTGGAAAACACCTCATGGCATAAAATAATGTTACTACTAGTTTTATGAAACTTTAGATCTATGAAAATTTGTAAAATTTCCTCTTCATTCAAGATCTCCTTGGCACCTAACTCTTGACAGAGGTCCCGGGTATGCTCCGTGTTGACAGATACCAGCCCATAGTTGATGTCCGCCCCCCACTCTGTAAATAGTTTTATAAGGCTGTAGTTGTTTTCCCTTACAGCCTTTACTAACGCCGTATTTAGGTCTAAGCCCTCTTTAATGCCTGATGATTTTATGAGCCTTAGGTTATGATCAAACGTGATCGGAGCATTATACCACCATAGATCATAATATTTTAAAAGATAATGTTGGTTCGTGGGCACGCATTGTCCAGCCAACACCTTTTTGGTCAAAGATTGCAGGGAAGGCAACAT
SEQ ID No.43–马拉维Lil-20/1(1983)MGF 360 12L(AY261361.1:27682-28731)
TCATCTTAAATCGTAGGAAAGGAAGGTCATCATATTTTTTGATTTATAATTTTTTAACACATGATCTATTATTTCAGGGTCCGTGTTTTTAGGTAACGGGGCAGTGGACGGACTATAGATCTTTAGGGATAAAATGTTCCTTATAAGCTCATACCCTTCCCCTACAGGCATATTCTCTTCGAAAACATCAGCCCCCAGATCCATACAAAAGAACATGTTTTCTATATTATAGTACTGTATTGAGGCAAGCATGGCCTGATTAATGTTGGCGCCCAGGACATAGCAGTAGTATATCGTTGAAAGGTTGTGGTCTTTGATGCAGGCTACTCGCATCATCTCTTCTAAGTCCATATAGATCTTGTCCTTTTCATACGCCTCATGAAGGTCAAACACATTATTAAAACAAAGAGCACATGTTAACCGCCACGTATTCAGGTGTGTATATTTTTGATAAAAATACTGTATGGCCTCTTTCAGGTTATAGCGTACGGCTATAGCGTACCAGTATTTGAGTAATAATGTATTGAGTGAAAACTCATTATTTAACAGATCGGTTTTTTTTATTAACTCCCTTAACTCCCAGAAAATTTCTATCCTCATTTTCAGATTATTTACTTTTTGTAATAACGGATTGTTGGAAAACACCTCATGGCATAAAATAATGTTACTACTAGTTTTATAAAACTTTAGATCGATGAAAATTCGTAAAATTTCCTCTTCATTTAAGGTCTCCTTGGCGCCTAGCTCTCTGCAGAGGTCCCGGGTGTGCTCCGTGTTGACAGATACCAGCCCGTAGTTGATGTCCGCCCCCCACTCTGTAAAAAGCTTTATAAGGTTGTAGTTGTTTTCCCTTACAGCCTTTACTAACGCCGTATTTAGGTCTAAGCCATCTTTAATGCCTGCTGATTTTATCAGCCCTAGGTTATGATCAAACGTGATCGGAGAATCATACCACCATAGGTCGTAACACTTTAAAAGATAATATTGGTCCGTCGGCAGGCATTGTCCAGCCAGTACCTTTTTGGTCAGAGATTGCAGGGAAGGCAACAT
SEQ ID No.44–Mkuzi 1979 MGF 360 12L(AY261362.1:31073-32125)
TCATCTTAAATCATAGGAAAGGAAGATCATCATATTTTTTGAAAAGTAATTTTTTAACGCATGATCTATGATTTCAGGGTCCGTGCTTTTAGGCAACGGGATGGTGGTCGGACTATAAATCTTTAGAGATAAAATGTTTTTTATAAGCTCATACCCTTCCCCTAAAGCTGTAGTACCCTCTTCGAAAACATCAGCCCCCAGATCCATACAAAAGAACATGTTTTCTATATTATAGTACTGTATTGAGGTAAGCATGGCCTGATTGATGTTGGCGCCCAACATATAGCAGTAGTACATGGTTGAAAGGTTGTGGTCTTTAATGCAGGCGATCCGCATCATCTCTTCTATGTCCATATAGATCTTGTCCTTTTCATACGCCTCATGGAGGTCAAACACATTATTAAAACAAAGAGCACATGTTAACCGCCACGTATTCAGGTGTGTATATTTTTGGTAAAAATACTGTATGGCTTCTTTCAGGTTATAGCGTATGGCTATAGCGTACCAGTATTTGAGTAGCAATGTACTGAGCGAAAACTCATTATTTAGCAGATCGGTTTTTTCTATTAACTCCCTTAACTCCCAAAAAATTTCTATCCTCATTTTTATATTATTTACTTTTTGTAATATCGGATTGTTGGAAAACACCTCATGGCATAAAATAATGTTACTACTAGTTTTATGAAACTTTAGATCTATAAAAATTTGTAAAATTTCTTTTTCATTCAAGGTCTCCTTGGCACCTAGCTCTCGACAGAGGTCCCAGGTGTGCTCCGAGCTGACAGATACCAGCCCATAGTTGATGTCCGCCCCCCACTCTGCAAACAATTTTATAAGGTTGTAGTTGTTTTCCTTTACAGCCTTCACCAACGCCGTATTTAGGTCTAAGCCCTCTTTAATGCCTGCTGATTTTATGAGCCTTAGGTTATGATCAAACGTGATCGGAGCATCATGCCACCATAGGTCATAATATTTTAAAAGATAATGTTGGTTCGTGGGCACGCATTGTCCGGCCAACACCTTTTTGGTCAAAGATTGCAGGGAAGGCAACAT
SEQ ID No.45–Pretorisuskop/96/4 MGF 360 12L(AY261363.1:30098-31150)
TCATCTTAAATCGTAGGTAAGGAAGATCATCATATTTTTTGAAACGTAATTTTTTAACGCATGATCTATAATTTCAGGGTCCGTGCTTTTAGGCAACGGGGTGGTGGCCGGACTATAAATCTTTAGGGATAAAATGTTCTTTATAAGCTTATACCCTTCCCCTAAAGCTATAGTGCCCTCTTCGAAAGCATCAGCCCCCAGATCCATACAAAAGAACATGTTTTCTATATTATAGTACTGTATTGAGGTAAGCATGGCCTGATTGATGTTGCCCCCCAGGACATAGCAGTAGTACATGGTTGAAAGGTTGTGGTCTTTGATGCAGGCGATCCGCATCATCTCTTCTATGTCCATATGAATCTTGTCCTTTTCATACGCCTCATGAAGGTCAAACACATTATTAAAACAAAGAGCACATGTTAACCGCCACGTATTCAGGTGTGTATATTTTTGGTAAAAATACTGTATGGCCTCTTTCAGGTTATAGCGTATGGCTATAGCGTACCAGTATTTAAGTAGTAATGTACTGAGCGAAAACTCATTATTTAGCAGATCGGTTTTTTCTATTAACTCCCTTAACTCCCAGAAAATTTCTATCCTCATTTTTATATTATTTACTTTTTGTAATATCGGATTGTTGGAAAACACCTCATGGCATAAAATAATGTTACTACTAGTTTTATGAAACTTTAGATCTATAAAAATTTGTAAAATTTCTTCTTCATTCAAGGTCTCCTTGGCACCTAGCTCTCGACAGAGGTCCCAGGTGTGCTCCGTGTTGACAGATACCAGCCCATAGTTGATGTTCGCCCCCCACTCTGCAAACAGTTTTATAAGGTTGTAGTTGTTTTCCCTTACAGCCTTCACTAACGCCGTATTTAGGTCTAAGCCCTCTTTAATGCCTGCTGATTTTATGAGCTTTAGGTTATGATCAAACGTGATCGGACCATCATGCCACCATAGGTCGTAACACTTTAAAAGATAATGTTGGTTTGTGGGCACGCATTGTCCAGCCAACACCTTTTTGGTCAGAGATTGCAGGGAAGGCAACAT
SEQ ID No.46–Tengani 62 MGF 360 12L(AY261364.1:24540-25592)
TCATCTTAAATCATAGGTAAGGAAGATCATCATATTTTTTGAAACGTAATTTTTTAACGCATGATCTATGATTTCAGGGTCCATGCTTTTAGGCAACGGGGTGGTGGCCGGACTATAAATCTTTAGGGATAAAATGTTCTTTATAAGCTCATACCCTTCCCCTAAAGCTGTAGTACCCTCTTCGAAAACATCAGCCCCCAGATCTATACAAAAGAACATGTTTTCTATATTATAGTACTGTATTGAGCTAAGCATGGCCTGATTGATGTTGGCGCCCAGGACATAGCAGTAGTACATGGTTGAAAGGTTGTGGTCTTTGATGCAGGCGATCCGCATCATCTCTTCTATGTCCATATGGATCTTGTCCTTTTCATACGCCTCATGAAGGTCAAACACATTATTAAAACAAAGAGCACATGTTAACCGCCACGTATTCAGGTGTGTATATTTTTGGTAAAAATACTGTATGGCCTCTTTCAGGTTATAGCGTATGGCTATAGCGTACCAGTATTTGAGTAGTAATGTACTGAGCGAAAACTCATTATTTAGCAGATCGGTTTTTTCTATTAACTCCCTTAACTCCCAGAAAATTTCTATCCTCATTTTTATATTATTTACTTTTTGTAATATCGGATTGTTGGAAAACACCTCATGGCATAAAATAATGTTACTACTAGTTTTATGAAACTTTAGATCTATAAAAATTTGTAAAATTTCTTCTTCATTCAAGGTCTCCTTGGCACCTAGCTCTCGACAGAGGTCCCAGGTGTGCTCCGTGTTGACAGATACCAGCCCGTAGTTGATGTCCGCCCCCCACTCTGCAAACAGTTTTATAAGGTTGTAGTTGTTTTCCCTTACAGCCTTTACTAACGCCGTATTTAGGTTTAAGCCCTCTTTAATACCTGCTGATTTTATGAGCCTTAGGTTATGATCAAACGTGATCGGAGCATCATGCCACCATAGGTCATAACACTTTAAAAGATAATGTTGGTTCGTGGGCACGCATTGTCCAGCCAACACCTTTTTGGTCAGAGATTGCAGGGAAGGCAACAT
SEQ ID No.47–Warmbaths MGF 360 12L(AY261365.1:29294-30346)
TCATCTTAAATCGTAGGTAAGGAAGATCATCATATTTTTTGAAACGTAATTTTTTACCGCATGATCTATGATTTCAGGGTCCGTGCTTTTAGGCAACGGGGTGGTGGCCGGACTATAAATCTTTAGGGATAAAATGTTCTTTATAAGCTTATACCCTTCCCCTAAAGCTATAGTACCCTCTTCGAAAGCATCAGCCCCCAGATCCATACAAAAGAACATGTTTTCTACATTATAGTACTGTATTGAGGTAAGCATGGCCTGATTGATGTTGGCGCCCAGAACATAGCAGTAGTACATGGTTGAAAGGTTGTGGTCTTTGATGCAGGCGATCCGCATCATCTCTTCTATGTCCATATAGATCTTGTCCTTTTCATACGCCTCATGAAGGTCAAACACATTATTAAAACAAAGAGCACATGTTAACCGCCATGTATTCAGGTGTGTATATTTTTGGTAAAAATACTGTATGGCCTCTTTCAGGTTATAGCGTATGGCTATAGCGTACCAGTATTTGAGTAGTAATGTACTGAGCGAAAACTCATTATTTAGCAGATCGGTTTTTTCTATTAACTCCCTTAACTCCCAGAAAATTTCTATCCTCATTTTTATATTATTTACTTTTTGTAATATCGGATTGTTGGAAAACACCTCATGGCATAAAATAATGTTACTACTAGTTTTATGAAACTTTAGATCTATAAAAATTTGTAAAATTTCTTCTTCATTCAAGGTCTCCTTGGCACCTAGCTCTCGACAGAGGTCCCGGGTGTGCTCCGTGTTGACAGATACCAGCCCATAGTTGATGTCCGCCCCCCACTCTGCAAACAGTTTTATAAGGTTGTAGTTGTTTTCCCTTACAGCCTTCACTAACGCCGTATTTAGGTCTAAGCCCTCTTTAATGCCTGCTGATTTTATGAGCTTTAGGTTATGATCAAACGTGATCGGACCATCATGCCACCATAGGTCATAACACTTTAAAAGATAATGTTGGTTCGTGGGCACGCATTGTCCAGCCAACACCTTTTTGGTCAGAGATTGCAGGGAAGGCAACAT
SEQ ID No.48–Warthog MGF 360 12L(AY261366.1:26036-27088)
TCATCTTAAATCGTAGGTAAGGAAGATCATCATATTTTTTGAAACGTAATTTTTTAACGCATGATCTATAATTTCAGGGTCCGTGCTTTTAGGCAACGGGGTGGTGGCCGGACTATAAATCTTTAGGGATAAAATGTTCTTTATAAGCTTATACCCTTCCCCTAAAGCTATAGTGCCCTCTTCGAAAGCATCAGCCCCCAGATCCATACAAAAGAACATGTTTTCTATATTATAGTACTGTATTGAGGTAAGCATGGCCTGATTGATGTTGGCGCCCAGGACATAGCAGTAGTACATGGTTGAAAGGTTGTGGTCTTTGATGCAGGCGATCCGCATCATCTCTTCTATGTCCATATGGATCTTGTCCTTTTCATACGCCTCATGAAGGTCAAACACATTATTAAAACAAAGAGCACATGTTAACCGCCACGTATTCAGGTGTGTATATTTTTGGTAAAAATACTGTATGGCCTCTTTCAGGTTATAGCGTATGGCTATAGCGTACCAGTATTTGAGTAGTAATGCACTGAGCGAAAACTCATTATTTAGCAGATCGGTTTTTTCTATTAACTCCCTTAACTCCCAGAAAATTTCTATCCTCATTTTTATATTATTTACTTTTTGTAATATCGGATTGTTGGAAAACACCTCATGGCATAAAATAATGTTACTACTAGTTTTATGAAACTTTAGATCTATAAAAATTTGTAAAATTTCTTCTTCATTCAAGGTCTCCTTGGCACCTAGCTCTCGACAGAGGTCCCGGGTGTGCTCCGTGTTGACAGATACCAGCCCATAGTTGATGTTCGCCCCCCACTCTGCAAACAGTTTTATAAGGTTGTAATTGTTTTCCCTTACAGCCTTCACTAACGCCGTATTTAGGTCTAAGCCCTCTTTAATGCCTGCTGATTTTATGAGCTTTAGGTTATGATCAAACGTGATCGGACCATCATGCCACCATAGGTCATAACACTTTAAAAGATAATGTTGGTTCGTGGGCACGCATTGTCCAGCCAACACCTTTTTGGTCAGAGATTGCAGGGAAGGCAACAT
在本发明的减毒ASFV的实施方案中，MGF 360 12L基因的表达和/或活性被破坏。适当地，MGF 360 12L基因包含SEQ ID No.37、38、39、40、41、42、43、44、45、46、47或48的序列。适当地，MGF 360 12L基因包含与SEQ ID No.37、38、39、40、41、42、43、44、45、46、47或48具有至少70％、至少80％、至少90％或至少95％的同一性的序列。适当地，MGF360 12L基因由SEQ ID No.37、38、39、40、41、42、43、44、45、46、47或48的序列组成。
MGF 360 13L基因序列
SEQ ID No.49–贝宁97/1MGF 360 13L(NC_044956.1:24840-25901)
CTATAATATATTATGAGAATATTCCCAAATGATGGATAAGTTTTTTGATTTATAATCTTTTAATAAACTGCTTATTTTTTCGGGGTCCTTTAAGTTTAATGGCAAGGAAGCATCTGAACTGTAAATATCCAAAGTCAAGCTATGGCTTAAAAAATTATAACCTTTTTGTTCCGCTATGGCACGACCCTCTTCAAAGGCATTACCACCCAAATCTATACAGAAAAATATATTACCGACGTTATAATATTGTACTGAAGTGAGCATAGCTTGGTTGATGTTGCCCCCCAGGGCGTAACAGTAATATATTGTTAATAGATTGTTATCCTTGGCACAAGCCAGACATATCATGTCATGGACGTCTATTTGGACTTTTTTCTTGTGGTACATCTCATGAAGCTCATATATTTTGTTATAATACAGGAGACATTTTAATCGCCACTCGTTAAGATCCGTATATTTCTCATCTAGAAAGCAAATGGCGTTCTTACAAACGTATTGTACTGCTTTGGCATACCAATACTTCACTAGTAAATCATTTAACTCGTCCGTTTCTTTTATTTCTATGAGCCCCCATAGTCTTTTATAAATTAAGCCCCTTAATTGTATAACAAATTTGTTTTCTAACATAGGATTATTCATAAAAATTTCATGGCACAAAATAATACTGCCGCTGGTTTTATTGTGCATTATCCTGGTGAAAATACGGAAAATATCGTTGTCCTCTAGAGTTTCTTTGGCGCCTAGCTGTCTACACAACTCTCGGATGTGCTTCGTATTGATAGAAAGCAAACTATAGTTGATATTTGCGCCCCACTCTGTAAAGAGCTTTATCAGACTATAGTTGTTTTCCTTAACAGCTATTATTAATGCCACACGAAGGTCTATATCTTCTCCTAAAAATCCTGATTTTATTTGTATTCGGCCACGATCCATACAAAGCTTGAGAGGAGCATCATGCCACCATAGGCCACAATATTTCAAAATGCAGTGTTCATCTATTGACAAACACTGGCTGGCTACCGTCTTTTTGACGAGGGTCTGCAGAGAGAGCGGCAACGACAT
SEQ ID No.50–中国/2018/安徽XCGQ MGF 360 13L(MK128995.1:30597-31658)
CTATAGTATATTATGAGAATATTCCCAAATGATGGATAAGTTTTTTGATTTATAATCTTTTAATAAACTGCTTATTTCTTCGGGGTCCTTTAAGTTTAGTGGCAAGGAAGCATCTGAGCTGTAAATATCCAAAGCCAAACTATGGCTCAGAAAATTATAACCTTTTTGTTCCGCTATGGCACGACCCTCTTCAAAGGCATTACCACCCAAATCTATACAGAAAAATATATTACCGATGTTATAATATTGTACTGAAGTAAGCATAGCTTGGTTGATGTTGCCCCCCAGCGCGTAACAGTAATATATTGTTAATGGATTGTTATCCTTGGTAGAAGCCAGACATATCATGTCATGGACGTCTATTTGGATGTTTTCCTTGTGGTACATCTCATGAAGCTCATATATTTTGTTATAATACAGGAGACATTTTAATCGCCATTCATTAAGATCCGTATATTTCTCATCTAGAAAACAAATGGCGTCCTTACAATCGTATTGTACTGCTTTGGCGTACCAATACTTCACTAGTAAACCATTTAACTCGTCCGTTTCTTTTATTTCTATGAGCCCCCATAGTCTTTTATAAATTAAGCCCCTTAATTGTATAACAAATTTGTTTTCTAAAATAGGATTATTCATAAAAATTTCATGGCACAAAATAATACTGCCGCTGGTTTTATTGTGCATTATCCTGGTAAAAATACGGAAAATATCGTTGTCCTCTAGAGTTTCTTTGGCGCCTAGCTGTCTACACAACTCTCGGATGTGCTTCGTATTGATAGAAAGCAAACCATAGTTGATATTTGCGCCCCACTCTGTAAAGAGCTTTATCAGACTATAGTTGTTTTCCTTAACAGCTATTATTAATGCCACACGAAGGTCTATATCTTCTCCTAAAAATCCTGATTTTATTTGTATTCGGCCACGATCCATACAAAGCTTGAGAGGAGCATCATGCCACCATAGGCCACAATATTTCAAAATGCAGTGTTCATCTATTGACAAACACTGGCTGGCTATCGTCTTTTTGACGAGGGTCTGCAGAGAGAGCGGCAACGACAT
SEQ ID No.51–格鲁吉亚2007/1MGF 360 13L(LR743116.1:31568-32629)
CTATAGTATATTATGAGAATATTCCCAAATGATGGATAAGTTTTTTGATTTATAATCTTTTAATAAACTGCTTATTTCTTCGGGGTCCTTTAAGTTTAGTGGCAAGGAAGCATCTGAGCTGTAAATATCCAAAGCCAAACTATGGCTCAGAAAATTATAACCTTTTTGTTCCGCTATGGCACGACCCTCTTCAAAGGCATTACCACCCAAATCTATACAGAAAAATATATTACCGATGTTATAATATTGTACTGAAGTAAGCATAGCTTGGTTGATGTTGCCCCCCAGCGCGTAACAGTAATATATTGTTAATGGATTGTTATCCTTGGTAGAAGCCAGACATATCATGTCATGGACGTCTATTTGGATGTTTTCCTTGTGGTACATCTCATGAAGCTCATATATTTTGTTATAATACAGGAGACATTTTAATCGCCATTCATTAAGATCCGTATATTTCTCATCTAGAAAACAAATGGCGTCCTTACAATCGTATTGTACTGCTTTGGCGTACCAATACTTCACTAGTAAACCATTTAACTCGTCCGTTTCTTTTATTTCTATGAGCCCCCATAGTCTTTTATAAATTAAGCCCCTTAATTGTATAACAAATTTGTTTTCTAAAATAGGATTATTCATAAAAATTTCATGGCACAAAATAATACTGCCGCTGGTTTTATTGTGCATTATCCTGGTAAAAATACGGAAAATATCGTTGTCCTCTAGAGTTTCTTTGGCGCCTAGCTGTCTACACAACTCTCGGATGTGCTTCGTATTGATAGAAAGCAAACCATAGTTGATATTTGCGCCCCACTCTGTAAAGAGCTTTATCAGACTATAGTTGTTTTCCTTAACAGCTATTATTAATGCCACACGAAGGTCTATATCTTCTCCTAAAAATCCTGATTTTATTTGTATTCGGCCACGATCCATACAAAGCTTGAGAGGAGCATCATGCCACCATAGGCCACAATATTTCAAAATGCAGTGTTCATCTATTGACAAACACTGGCTGGCTATCGTCTTTTTGACGAGGGTCTGCAGAGAGAGCGGCAACGACAT
SEQ ID No.52–Ken06.Bus MGF 360 13L(NC_044946.1:28644-29704)
TTAGAGTATTTTATGAGAGTAATCCAGAATGATGGATAAATTTTTTGATTTATAATTTTTTAATAAACTGCTTATTTCTTCGGGATCCTTTAAGTTTAATGGCAAGGAAGCATCTGAGCTATAAATATTCAAAACCAAACTATGGCTTAAAAAATTATAACCATTTTGTCTCGCTATGGCACTACCCTCTTCAAAGGCATTACCACCCAAATCTATACAGAAATATATATTACCGATGTTATAATATTGTACTGAAGTAAGCATAGCTTGATTGATGTTGCCCCCCAGGGCATAACAATAATATATTGTTAATAGATTGTTATCCCTGATACAAGCCAGAGATAACATTTCATTGACGTCTATTTGGATTTTTTCCTTGTGGTATATATCATGAAGCTCATATATTTTGTTATAACATAGGTAACATTTTAATCACCATTCATCAAGATCCGTATATTTTTCATCCAGAAAGCAAATGGCATCTTTATGGTCGTATTGTACTGCATTGGCGTACCAATATTTCACTAGCAATTCGCTTAACTCGTCCGTTTCTTTTATTTCTATAAGCCCGCATAGTCTTTTATAAATTAAGCGCCTTAATTGTGCAGCAAAGTTGTTTTCTAAATTAGGATTATTTATAAATATCTCATGGCACAAAATAATACTGCCGCTAGTTTTATTATGCATTATCTTGTTGAAAATACAGAAAATATCGTAGTCGTCTAGAGTTTCTTTGGCGCCTAGCTGTCTACACAAATCTCGGGCGTGCTTCGTATTGATAGAAAGCAGACTATAGTTGATATATGCGCCCCACTCTGTAAATAACTTTATCATACTATAGTTGTTTTCCTTAACAGCTATTATTAATGCCACACAAAGGTCTATATCTTCTCCTAGGAATCCCGATTTTATGTATATTCGCCCACGATCTATGTAAAGCTTGAGGGGAGCATCATGCCACCATAAGCCACAGTATTTCAAAATGTGTTCATCTATCGACAAACATGATGTACCGGCTACCGTCTTTTTGACGAGGGTCTGCAGAGAGAGCGGCGACGACAT
SEQ ID No.53–肯尼亚1950MGF 360 13L(AY261360.1:34752-35812)
TTAGAGTATTTTATGAGAGTAATCCAGAATGATGGATAAATTTTTTGATTTATAATTTTTTAATAAACTGCTTATTTCTTCGGGAACCTTTAAGTTTAATGGCAAGGAAGCATCTGAGCTATAAATATTCAAAATTAAACTATGGCATAAAAAATTATAACCATTTTGTCTCGCTATGGCACTACCCTCTTCAAAGGCATTACCACCCAAATCTATACAGAAATATATATTACCGATGTTATAATATTGTACTGAAGTAAGCATAGCTTGGTTGATGTTGCCCCCCAGGGCATAACAATAATATATTGTTAATAGATTGTTATCCCTGATACAAGCCAGAGATAACATTTCATTGACGTCTATTTGGATTTTTTTCTTGTGGTATATATCATGAAGCTCATATATTTTGTTATAACATAGGTAACATTTTAATCGCCATTCATCAAGATCCGTATATTTTTCATCCAGAAAGCAAATGGCATCTTTATGATCGTATTGTACTGCATTGGCGTACCAATATTTCACTAGTAATTCGCTTAACTCGTCCGTTTCTTTTATTTCTATAAGCCCGCATAATCTTTTATAAATTAAGCGCCTTAATTGTGCAGCAAAGTTGTTTTCTAATTTAGGATTATTTATAAATATCTCATGGCACAAAATAATACTGCCGCTAGTTTTATTATGCATTATTTTATTGAAAATACAGAAAATATCGTAGTCGTCTAGAGTTTCTTTGGCGCCTAGCTGTCTACACAAATCTCGGGCGTGCTTCGTATTGATAGAAAGCAGACTATAGTTGATATATGCGCCCCACTCTGTAAATAACTTTATCAGACTATAGTTATTTTCCTTAACAGCTATTATTAATGCCACACAAAGGTCTATATCTTCTCCTAGGAATCCCGATTTTATGTATATTCGTCCACGATCTATGTAAAGCTTGAGGGGAGCATCATGCCACCATAAGCCACAGTATTTCAAAATGTGTTCATCTATCGACAAACATGATGTACTGGCTACCGTCTTTTTGACGAGGGTCTGCAGAGAGAGCGGCGACGACAT
SEQ ID No.54–L60 MGF 360 13L(NC_044941.1:25189-26250)
CTATAATATATTATGAGAATATTCCCAAATGATGGATAAGTTTTTTGATTTATAATCTTTTAATAAACTGCTTATTTTTTCGGGGTCCTTTAAGTTTAATGGCAAGGAAGCATCTGAACTGTAAATATCCAAAGTCAAGCTATGGCTTAAAAAATTATAACCTTTTTGTTCCGCTATGGCACGACCCTCTTCAAAGGCATTACCACCCAAATCTATACAGAAAAATATATTACCGACGTTATAATATTGTACTGAAGTGAGCATAGCTTGGTTGATGTTGCCCCCCAGGGCGTAACAGTAATATATTGTTAATAGATTGTTATCCTTGGCACAAGCCAGACATATCATGTCATGGACGTCTATTTGGACTTTTTTCTTGTGGTACATCTCATGAAGCTCATATATTTTGTTATAATACAGGAGACATTTTAATCGCCACTCGTTAAGATCCGTATATTTCTCATCTAGAAAGCAAATGGCGTTCTTACAAACGTATTGTACTGCTTTGGCATACCAATACTTCACTAGTAAATCATTTAACTCGTCCGTTTCTTTTATTTCTATGAGCCCCCATAGTCTTTTATAAATTAAGCCCCTTAATTGTATAACAAATTTGTTTTCTAACATAGGATTATTCATAAAAATTTCATGGCACAAAATAATACTGCCGCTGGTTTTATTGTGCATTATCCTGGTGAAAATACGGAAAATATCGTTGTCCTCTAGAGTTTCTTTGGCGCCTAGCTGTCTACACAACTCTCGGATGTGCTTCGTATTGATAGAAAGCAAACTATAGTTGATATTTGCGCCCCACTCTGTAAAGAGCTTTATCAGACTATAGTTGTTTTCCTTAACAGCTATTATTAATGCCACACGAAGGTCTATATCTTCTCCTAAAAATCCTGATTTTATTTGTATTCGGCCACGATCCATACAAAGCTTGAGAGGAGCATCATGCCACCATAGGCCACAGTATTTCAAAATGCAGTGTTCATCTATTGACAAACACTGGCTGGCTACCGTCTTTTTGACGAGGGTCTGCAGAGAGAGCGGCAACGACAT
SEQ ID No.55–马拉维Lil-20/1(1983)MGF 360 13L(AY261361.1:28920-29980)
TTAGAGTATATTATGAGAGTAATCCAAAATGATGGATAAATTTTTTGATTTATAATTTTTTAACAAACTGCTTATTTCTTCGGGGTCCTTTAAGTTTAATGGCAAGGAAGCATCCGAGCTATAAATATTCAAAACCAAACTATGGCTTAGAAAATTATAACCTTTTTGTCTCGCTATGGCACTACCCTCTTCAAAGGCATTACCACCCAAATCTATACAGAAATATATATTACCGATGTTATAATATTGCACTGAAGTAAGCATAGCTTGGTTGATGTTGCCCCCCAGGGCATAACAGTAATATATTGTTAATGGATTGTTATCCCTGATACAAGCCAGGGATAACATTTCATTAACGTCTATTTGGATTTTTTCCTTGTGGTATATATCATGAAGCTCATATATTTTGTTATAATATAGGTAACATTTTAATCGCCATTCATTAAGATCCGTATATTTCTCATCCAGAAAGCAAATGGCATCTTTATAATCGTATTGTACTGCTTTGGCGTACCAATATTTCACTAGTAATTCACTTAACTCGTCCGTTTCTTTTATTTCTATAAGCCCGCATAGTCTTTTATAAATTAAGCGCCTTAATTGTGCAGCAAATTTGTTTTCTAAATTAGGATTATTTATAAATATCTCATGGCACAAAATAACACTGCCGCTGGTTTTATTATGCATTATCTTGTTGAAAATACAGAAAATATCGTAGTCCTCCAGAGTTTCTTTGGCGCCTAGCTGTCTACACAAATCTCGGACGTGCTTCGTATTGATAGAAAGCAGACTATAGTTGATATTTGCGCCCAACTCTGTAAAAAGCTTTATTAGATTATAGTTGTTTTCCTTAACAGCTATTATTAATGCCACACAAAGGTCTATATCTTCTCCTAAAAATCCCGATTTTATTTGTATTCGGCCACGATCCATATAAAGCTTGAGAGGGGCATCATGCCACCATAAGTCACAGTATTTCAAAATGTGTTCATCTATCGACAAACATGATGTACTGGCTACCGTCTTTTTGACGAGGGTTTGTAGAGAGAGCGGCGCCGACAT
SEQ ID No.56–Mkuzi 1979MGF 360 13L(AY261362.1:32286-33347)
CTATAATATATTATGAGAATATTCCCAAATGATGGATAAGTTTTTTGATTTATAATCTTTTAATAAACTGCTTATTTCTTCGGGGTCCTTTAAGTTTAATGGCAAGGAAGCATCTGAACTGTAAATATCCAAAGTCAAGCTATGGCTTAAAAAATTATAACCTTTTTGTTCCGCTATGGCACGACCCTCTTCAAAGGCATTACCCCCCAAATCTATACAGAAAAATATATTACCGATGTTATAATATTGTACTGAAGTGAGCATAGCTTGGTTGATGTTGCTCCCCAGGGCGTAACAGTAATATATTGTTAATAGATTGTTATCCTTGGCACAAGCCAGACATATCATGTCATGGACGTCTATTTGGACTTTTTTCTTGTGGTACATCTCATGAAGCTCATATATTTTGTTATAATACAGGAGACATTTTAATCGCCATTCGTTAAGATCCGTATATTTCTCATCTAGAAAGCAAATGGCGTTCTTACAAACGTATTGTACTGCTTTGGCATACCAATACTTCACTAGTAAATCATTTAACTTGTCCGTTTCTTTTATTTCTATGAGCCCCCATAGTCTTTTATAAATTAAGCCCCTTAATTGTATAACAAATTTGTTTTCTAAAATAGGATTATTCATAAAAATTTCATGGCACAAAATAATACTGCCGCTGGTTTTATTGTGCATTATCCTGGTGAAAATACGGAAAATATCGTTGTCCTCTAGAGTTTCTTTGGCGCCTAGCTGTCTACACAACTCTCGGATGTGCTTCGTATTGATAGAAAGCAAACTATAGTTGATATTTGCGCCCCACTCTGTAAAGAGCTTTATCAGACTATAGTTGTTTTCCTTAACAGCTATTATTAATGCCACACGAAGGTCTATATCTTCTCCTAAAAATCCTGATTTTATTTGTATTCGGCCACGATCCATACAAAGCTTGAGAGGAGCATCATGCCACCATAGGCCACAGTATTTCAAAATGCAGTGTTCATCTATTGACAAACACTGGCTGGCTACCGTCTTTTTGACGAGGGTCTGCAGAGAGAGCGGCAACGACAT
SEQ ID No.57–Pretorisuskop/96/4 MGF 360 13L(AY261363.1:31307-32368)
CTATAGTATATTATGAGAATATTCCCAAATTATGGATAAGTTTTTTGATTTATAATCCTTTAAAAAACTGCTTATTTCTTCGGGGTCCTTTAAGTTTAGTGGCAAGGAAGCATCTGAGCTGAAAATATCCAAAGCCAAACTATGGCTTAGAAAATTATAACCTTTTTGTTCCGCTATGGCACGACCCTCTTCAAAGGCATTACCACCCAAATCTATACAGAAAAATATATTACCGATGTTATAATATTGTATTGAAGTAAGCATAGCTTGGTTGATGTTGCCCCCCAGGGCGTAACAGTAATATATTGTTAATGGATTGTTATCCTTGGTAGAAGCCAGACATATCATGTCATGGACGTCTATTTGGACTTTTTCCTTGTGGTACATCTCATGAAGCTCATATATTTTGTTAAAATACAGGAGACATTTTAATCGCCATTCATTAAGATCCGTATATTTCTCTTCTAGAAAGCAAATGGCGTCCTTACACTCGTATTGTACTGCTTTGGCGTACCAATACTTCACTAGTAAATCGTTTAACTCATCCGTTTCTTTTATTTCTATGAGCCCCCATAGTCTTTTACAAATTAAGCCCCTTAATTGTATAGTAAATTTGTTTTCTATATTAGGATTATTCATAAATATATCATGGCACAAAATAATACGGCCGCTGGTTTTATTGTGCATTATCTTGGTGAAAATACGGAAAACATCGTCGTCTTCTAGAGTTTCTTTGGCGCCTAGCTGTCTACACAACTCTCGGATGTGCTCCGTATTAATAGAAAGCAAACTATAGTTGATATGTGCGCCCCATTCTGTAAAGAGCTTTATCAGACTATAGTTGTTTTCCTTAACAGCTATTATTAATGCTATATGGAGGTCTATATCCTCTCCTAAAAATCCTGATTTTATTTGTATTTGGCCACGATCCATACAAAGCTTGAGGGGGACATCATGCCACCATAGGCCACAGTGTTTCAGAATGCAGTGTTCATCTATCGACAAACACTGGCTGGCTACCGTCTTTTTGACGAGGGTCTGCAGAGAGAGCGGCAACGACAT
SEQ ID No.58–Tengani 62 MGF 360 13L(AY261364.1:25753-26814)
CTATAGTATATTATGAGAATATTCCCAAATGATGGATAAGTTTTTTGATTTATAATCTTTTAATAAACTGCTTATTTCTTCGGGGTCCTTTAAGTTTAGTGGCAAGGAAGCATCTGAGCTGTAAATATCCAAAGCCAAACTATGGCTCAGAAAATTATAACCTTTTTGTTCCGCTATGGCACGACCCTCTTCAAAGGCATTACCACCCAAATCTATACAGAAAAATATATTACCGATGTTATAATATTGTACTGAAGTAAGCATAGCTTGGTTGATGTTGCCCCCCAGCGCGTAACAGTAATATATTGTTAATGGGTTGTTATCCTTGGTAGAAGCCAGACATATCATGTCATGGACGTCTATTTGGATGTTTTCCTTGTGGTACATCTCATGAAGCTCATATATTTTGTTATAATACAGGAGACATTTTAATCGCCATTCATTAAGATCCGTATATTTCTCATCTAGAAAGCAAATGGCGTCCTTACACTCGTATTGTACTGCTTTGGCGTACCAATACTTCACTAGTAAACCGTTTAACTCATCCGTTTCTTTTATTTCTATGAGCCCCCATAGTCTTTTATAAATTAAGCCCCTTAATTGTATAGTAAATTTATCTTCTATATTAGGATTATTCATAAATATATCATGGCACAAAATAATACTGCCGCTGGTTTTATTGTGCATTATCTTGGTGAAAATACGGAAAATATCGTCGTCTTCTAGAGTTTCTTTGGCGCCTAGCTGTCTACACAACTCTCGGATGTGCTTCGTATTGATAGAAAGCAAACTATAGTTGATATTTGCGCCCCACTCTGTAAAGAGCTTTATCAGACTATAGTTGTTTTCCTTAACAGCTATTATTAATGCTATATGGAGGTCTATATCTTCTCCTAAAAATCCTGATTTTATTTGTATTTGGCCACGATCCATACAAAGCTTGAGGGGGACATCATGCCACCATAGGCCACAGTGTTTCAGAATGCAGTGTTCATCTATCGACAAAGACTGGTTGGCTACCGTCTTTTTGACGAGGGTCTGCAGAGAGAGCGGTAATGACAT
SEQ ID No.59–Warmbaths MGF 360 13L(AY261365.1:30498-31559)
CTATAGTATATTATGAGAATATTCCCAAATGATGGATAAGTTTTTTGATTTATAACCCTTTAATAAACTGCTTATTTCTTCGGGGTCCTTTAAGTTTAGTGGCAAGGAAGCATCTGAGCTGTAAATATCCAAAGCCAAACTATGGCTTAGAAAATGATAACCTTTTTGTTCCGCTATGGCACGACCCTCTTCAAAGGCATTACCACCCAAATCTATACAGAAAAATATATTACCGATGTTATAATATTGTACTGAAGTAAGCATAGCTTGGTTGATGTTGCCCCCCAGGGCGTAACAGTAATATATTGTTAATGGATTGTTATCCTTGGTAGAAGCCAGACATATCATGTCATGGACGTCTATTTGGACTTTATCCTTGTGGTACATCTCATGAAGCTCATATATTTTGTTATAATACAGGAGACATTTTAATCGCCATTCATTAAGACCCGTATATTTCTCATCTAGAAAGCAAATGGCGTCCTTACACTCGTATTGTACTGCTTTGGCGTACCAATACTTCACTAGTAAATCGTTTAACTCATCCGTTTCTTTTATTTCTATGAGCCTCCATAGTCTTTTACAAATTAAGCCCCTTAATTGTATAGTAAATTTGTTTTCTATATTAGGATTATTCATAAATATCTCATGGCACAAAATAATACGGCCGCTGGTTTTATTGTGCATTATCTTGGTGAAAATACGGAAAATATCGTTGTCCTCTAGAGTTTTTTTGGCACCTAGCTGTCTACACAACTCTCGGATGTGTTCCGTATTGATAGAAAGCAAACTATAGTTGATATGTGCGCCCCATTCTGTAAAGAGCTTTATCAGACTATAGTTGTTTTCCTTAACAGCTATTATTAATGCTACATGGAGATCTATATCTTCTCCTAAAAATCCTGATTTTATTTGTATTTGGCCACGATCCATACAAAGCTTGAGGGGGACATCATGCCACCATAGGCCACAGTGTTTCAGAATGCAGTGTTCATCTGTCGACAAACACTGGCTGGCTACCGTTTTTTTGACGAGGGTCTGCAGAGAGAGCGGCAACGACAT
SEQ ID No.60–Warthog MGF 360 13L(AY261366.1:27277-28338)
CTATAGTATATTATGAGAATATTCCCAAATGATGGATAAGTTTTTTGATTTATAATCCTTTAATAAACTGCTTATTTCTTCGGGGTCCTTTAAGTTTAGTGGCAAGGAAGCATCTGAGCTGTAAATATCCAAAGTCAAACTATGGCTTAGAAAATGATAACCTTTTTGTTCCGCTATAGCACGACCCTCTTCAAAGGCATTACCACCCAAATCTATACAGAAAAATATATTACCGATGTTATAATATTGTACTGAAGTAAGCATAGCTTGGTTGATGTTGCCCCCCAGGGCGTAACAATAATATATTGTTAATGGATTGTTATCCTTGGTAGAAGCCAGACATATCATGTCATGGACGTCTATTTGGACTTTTTCCTTGTGGTACATCTCATGAAGCTCATATATTTTGTTATAATACAGGAGACATTTTAATCGCCATTCATTAAGATCCGTATATTTCTCATCTAGAAAGCAAATGGCGTCCTTACACTCGTATTGTACTGCTTTGGCGTACCAATACTTCACTAGTAAATCGTTTAACTCATCCGTTTCTTTTATTTCTATGAGCCCCCATAGTCTTTTACAAATTAAGCCCCTTAATTGTATAGTAAATTTGTTTTCTATATTAGGATTATTCATAAATATCTCATGGCACAAAATAATACGGCCGCTGGTTTTATTGTGCATTATCTTGGTGAAAATACGGAAAATATCGTTGTCCTCTAGAGTTTCTTTGGCACCTAGCTGTCTACACAACTCTCGGATGTGCTCCGTATTGATAGAAAGCAAACTATAGTTGATATGTGCGCCCCATTCTGTAAAGAGCTTTATCAGACTATAGTTGTTTTCCTTAACAGCTATTATTAATGCTATATGGAGGTCTATATCTTCTCCTAAAAATCCTGATTTTATTTGTATTTGGCCACGATCCATACAAAGCTTGAGGGGGACATCATGCCACCATAGGCCACAGTGTTTCAGAATGCAGTGTTCATCTGTCGACAAACACTGGCTGGCTACCGTCTTTTTGACGAGGGTCTGCAGAGAGAGCGGCAACGACAT
在本发明的减毒ASFV的实施方案中，MGF 360 13L基因的表达和/或活性被破坏。适当地，MGF 360 13L基因包含SEQ ID No.49、50、51、52、53、54、55、56、57、58、59或60的序列。适当地，MGF 360 13L基因包含与SEQ ID No.49、50、51、52、53、54、55、56、57、58、59或60具有至少70％、至少80％、至少90％或至少95％的同一性的序列。适当地，MGF360 13L基因由SEQ ID No.49、50、51、52、53、54、55、56、57、58、59或60的序列组成。
MGF 360 14L基因序列
SEQ ID No.61–贝宁97/1MGF 360 14L(NC_044956.1:26073-27146)
TTAGTCTATAACTATAATTTCTGGATGGGCTGTAAGATACTCTTCGGCTCGTTTCATATTTTTTGAAGTATATGTCTTTAGCATATCATATATTTCCTGGGGTTCGGTTACATCTAATACCAAGGTCACATCACGGCTGAAAAGCTGCTTTACTAAGAAAATGTTGCTCAAGTTATACATATAAGCTTTGTGCGCAATGAGTTGTGCCCTATCAAAATCGGCGGCCCCCAAATCAATACAGAAAAACATGTTTAAAGTATTATTGTTATAGATAGAAAGATTCATGCCATAATCGAGACTAGCCCCCAACCTATGACAGTAATAAATGGCCGCGTAATTTTTTTCCCGCAAGCAAGCAAATTTCATCATCAGATTAGGGCTAATGCAAATCTCTTTTTCACGACACAGCTCGTGTATGTCAAAAATGTTATTAAAATAAAGGCTACAAGCTACCCGCCAATAGAGCTGATTTTTATGCCTTTTATAAAAATAGTGGATAGCCTTTGTAAAATTATGTCGTAATGCCAGGGCAAACCAAAACTTTGTTAATAGGAGGTGCGCCGTATCCCCCGTCAACGGAATGTTTGAACAGGTGTACGTAACTGTGTCTAAAGTGGTTCTAGTTACGGTTTCCAAGAGTGGATTATGACAAAACATGTCATAACCCAGTAGAACTCCTGCACAGGATTTTAGGTTGGCCACTTCTTTTAAAATTTCCAGAAGACGGGGTTCGGATACAGGCGTCAAGCCTCCCAGTTCCGCACACAGCCGCTTTAGATACACGGCAGGAACACGTATAAGCCCATATTCAGGATTTGCGCCCCAATCCACAAATAAACGTATAAGTTCAAGATTATCGCTCTTCACGGCCTTTACTAGCGCCGCTTCAAGACAAAGATCATCCTCAGAAAAACACTGTAAATGTTTATACGAAAAAACTTGCTTACAATTGTTACATAGGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAACGTATAATCATAGTCACTTGAAAGATAATTGCATGCCACAACTTTTTTGGCCAACGTTTGTAAAGACAACAT
SEQ ID No.62–中国/2018/安徽XCGQ MGF 360 14L(MK128995.1:31843-32916)
TTAGTCTATAACTATAATTTCTGGATGGGCTGTAAGATACTCTTCGGCTCGTTTCAGATTTTTTGAAGTATATGTCTTTAGCATATCATATATTTCCTGGGGTTCGGTTACATCTAATACCAAGGTCACATCACGGCTGAAAAGCTGCTTTACTAAGAAAATGTTGCTCAAGTTATACATATAAGCTTTGTGCGCAATGAGTTGTGCCCTATCAAAATCGGCAGCCCCCAAATCAATACAGAAAAACATGTTTAAAGTATTATTGTTATAGATAGAAAGATTCATGCCATAATCGAGACTAGCCCCCAACCTATGACAGTAATAAATGGCCGCGTAATTTTTTTCCCGCAAGCAAGCAAATTTCATCATCAGATTAGGGCTGATGCAAATCTCTTTTTCACGACACAACTCGTGTATGTCAAAAATGTTATTAAAATAAAGGCTACAAGCTACCCGCCAATAGAGGTGATTTTTATGCCTTTTATAGAAATAGTGAATAGCCTTTGTAAAATTATGTCGTAATGCCAGGGCAAACCAAAACTTTGTTAATAGGTGGTGCGCCGTATCCCCCGTCAACGGAATGTTTGAACAGGTGTACGTAACTGTGTCTAAAGTGGTTCTAGTTACGGTTTCCAAGAGTGGATTATGACAAAACATGTCATAACCCAGCAGAACTCCTGCACAGGATTTTAGCCTGGCCACTTCTTTTAAAATTTCCAGAAGACGGGGTTCGGATACAGGCGTTAAGCCTCCCAGTTCCGCACACAGCCGCTTTAGATACACGGCAGGAACACGTATAAGCCCATATTCAGGATTTGCGCCCCAATCCACAAATAAACGTATAAGTTCAAGATTATCGCTCTTCACGGCCTTTACTAGCGCCGCTTCGAGACAAAGATCATCCTCAGAAAAACACTGTAAATGTTTATACGAAAAAACTTGCTTACAATTGTTACATAGGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAACGTATAATCATAGTCACTTGAAAGATAATTGCATGCCACAACTTTTTTGGCCAACGTTTGTAAAGACAACAT
SEQ ID No.63–格鲁吉亚2007/1MGF 360 14L(LR743116.1:32814-33887)
TTAGTCTATAACTATAATTTCTGGATGGGCTGTAAGATACTCTTCGGCTCGTTTCAGATTTTTTGAAGTATATGTCTTTAGCATATCATATATTTCCTGGGGTTCGGTTACATCTAATACCAAGGTCACATCACGGCTGAAAAGCTGCTTTACTAAGAAAATGTTGCTCAAGTTATACATATAAGCTTTGTGCGCAATGAGTTGTGCCCTATCAAAATCGGCAGCCCCCAAATCAATACAGAAAAACATGTTTAAAGTATTATTGTTATAGATAGAAAGATTCATGCCATAATCGAGACTAGCCCCCAACCTATGACAGTAATAAATGGCCGCGTAATTTTTTTCCCGCAAGCAAGCAAATTTCATCATCAGATTAGGGCTGATGCAAATCTCTTTTTCACGACACAACTCGTGTATGTCAAAAATGTTATTAAAATAAAGGCTACAAGCTACCCGCCAATAGAGGTGATTTTTATGCCTTTTATAGAAATAGTGAATAGCCTTTGTAAAATTATGTCGTAATGCCAGGGCAAACCAAAACTTTGTTAATAGGTGGTGCGCCGTATCCCCCGTCAACGGAATGTTTGAACAGGTGTACGTAACTGTGTCTAAAGTGGTTCTAGTTACGGTTTCCAAGAGTGGATTATGACAAAACATGTCATAACCCAGCAGAACTCCTGCACAGGATTTTAGCCTGGCCACTTCTTTTAAAATTTCCAGAAGACGGGGTTCGGATACAGGCGTTAAGCCTCCCAGTTCCGCACACAGCCGCTTTAGATACACGGCAGGAACACGTATAAGCCCATATTCAGGATTTGCGCCCCAATCCACAAATAAACGTATAAGTTCAAGATTATCGCTCTTCACGGCCTTTACTAGCGCCGCTTCGAGACAAAGATCATCCTCAGAAAAACACTGTAAATGTTTATACGAAAAAACTTGCTTACAATTGTTACATAGGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAACGTATAATCATAGTCACTTGAAAGATAATTGCATGCCACAACTTTTTTGGCCAACGTTTGTAAAGACAACAT
SEQ ID No.64–Ken06.Bus MGF 360 14L(NC_044946.1:29917-30990)
TTAGTCTATAACGACAATTTCTGGATGGGCTGTAAAATACTCTTCGGCTCGTTTTAGATTTTTTGACGTATATGTCTTTAGCATATCATATATTGCCTGGGGTTCGGTTATATTTAATACCAAGCTCGCATCACGGCTGAAAAGCTGTTTTACTAAAAAAATGTTGCTCAAGTTATACATATAAACTCTATGCGCAATGAGTCGCGCTCTATCAAAGTTAGTAGCCCCCAAATCAATGCAGAAAAATAGGTTTAAAGTATTATTGTTATAGATAGATAGATTCATGCCATAATCGGGACTAGCCCCCAACATATGACAGTAATAAATGGCTGCATAATTTTCTTCCCGCAGGCAAGCAAATTTCATCATTAGATTAGGGCTAATGCAAATCTCTTTTTTAGAACACAGCTCATGCAAGTCAAAAATGTTATTAAAATAAAGGCTACAAGTTAGCCGCCAATACAGCTGATTTTTATGTTTTTCGTAGAAATAGTGAATCGCTTTTGTAAAATTATGCCGTAATGCCAGGGCAAACCAAAACTTCGTTAATAGGAGGTGCGCCGTATCCCCCGTCAACGGAATTTTTGAACGGGTATACATAACTGTGTTTAAAGTGGTTCTAGTCACGGTTTCCATAAGTGGATTATGACAAAACATGTCATAACCCAGTAGAACTCCTGCACAGGATTTCAGATCGGCCACTTCTTTTAAAATTTCCAGAAGACGAGATTCGGAGACAGGTGTTAAGCCTCCTAGTTCCGTGCACAGCCGTTTTAGATGCACGGCAGGAACACGTATAAGTCCATATTCAGGATTTGCGCCCCAATCCACAAACAATCGTATAAGCTCAAGATTATCGCTCTTCACGGCCTTTACTAGCGCCGCGTCAAGACAAAGATCATCCACAGAAAAACACTGCAAATGTTGATACGAAAAAATTTGCTTACATGTATTACATAAGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAGCGTATAATCATAGTCACTTGAAAGATAATTGCACGCCACAACTTTTTTGGCCAACGTTTGTAAAGACAACAT
SEQ ID No.65–肯尼亚1950MGF 360 14L(AY261360.1:36121-37194)
TTAGTCTATAACTACAATTTCTGGATGGGCTGTAAAATACTCTTCGGCTCGTTTTAGATTTTTTGACGTATATGTCTTTAGCATATCATATATTGCCTGGGGTTCGGTTATATTTAATACCAAGCTCGCATCACGGCTGAAAAGCTGTTTTACTAAAAAAATGTTGCTCAAGTTATACATATAAACTCTATGCGCAATGAGTCGCGCTCTATCAAAGTTAGTAGCCCCCAAATCAATACAGAAAAATAGGTTTAAAGTATTATTGTTATAGATAGATAGATTCATGCCATAATCGGGACTAGCCCCCAACATATGACAGTAATAAATGGCTGCATAATTTTCTTCCCGCAGGCAAGCAAATTTCATCATTAGATTAGGGCTAATGCAAATCTCTTTTTTAGAACACAGCTCATGCAAGTCAAAAATATTATTAAAATAAAGGCTACAAGCCAGCCGCCAATAGAGCTGATTTTTATGCTTTTCATAGAAATAGTGAATCGCTTTTGTAAAATTATGTCGTAATGCCAGGGCAAACCAAAACTTCGTTAATAGGAGGTGCGCCGTATCCCCCGTCAACGGAATTTTTGAACGGGTGTACATAACGGTGTTTAAAGTGGTTCTAGTCACGGTTTCCAAGAGTGGATTATGACAAAACATGTCATAACCCAGTAGAACTCCTGCACAGGATTTCAGATCGGCCACTTCTTTTAAAATTTCCAGAAGACGAGATTCGGAGACAGGTGTTAAGCCTCCTAGTTCTGTGCACAGCCGTTTTAGATCCACGGCAGGAACACGTATAAGTCCATATTCAGGATTTGCGCCCCAATCCACAAACAATCGTATAAGCTCAAGATTATCGCTCTTCACGGCCTTTACTAGCGCCGCGTCAAGACAAAGATCATCCTCAGAAAAACACTGCAAATGTTGATACGAAAAAATTTGCTTACATGTATTACATAAGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAGCGTATAATCATAGTCACTTGAAAGATAATTGCATGCCACAACCTTTTTGGCCAACGTTTGTAAAGACAACAT
SEQ ID No.66–L60 MGF 360 14L(NC_044941.1:26422-27495)
TTAGTCTATAACTATAATTTCTGGATGGGCTGTAAGATACTCTTCGGCTCGTTTCATATTTTTTGAAGTATATGTCTTTAGCATATCATATATTTCCTGGGGTTCGGTTACATCTAATACCAAGGTCACATCACGGCTGAAAAGCTGCTTTACTAAGAAAATGTTGCTCAAGTTATACATATAAGCTTTGTGCGCAATGAGTTGTGCCCTATCAAAATCGGCGGCCCCCAAATCAATACAGAAAAACATGTTTAAAGTATTATTGTTATAGATAGAAAGATTCATGCCATAATCGAGACTAGCCCCCAACCTATGACAGTAATAAATGGCCGCGTAATTTTTTTCCCGCAAGCAAGCAAATTTCATCATCAGATTAGGGCTAATGCAAATCTCTTTTTCACGACACAGCTCGTGTATGTCAAAAATGTTATTAAAATAAAGGCTACAAGCTACCCGCCAATAGAGCTGATTTTTATGCCTTTTATAAAAATAGTGGATAGCCTTTGTAAAATTATGTCGTAATGCCAGGGCAAACCAAAACTTTGTTAATAGGAGGTGCGCCGTATCCCCCGTCAACGGAATGTTTGAACAGGTGTACGTAACTGTGTCTAAAGTGGTTCTAGTTACGGTTTCCAAGAGTGGATTATGACAAAACATGTCATAACCCAGTAGAACTCCTGCACAGGATTTTAGGTTGGCCACTTCTTTTAAAATTTCCAGAAGACGGGGTTCGGATACAGGCGTCAAGCCTCCCAGTTCCGCACACAGCCGCTTTAGATACACGGCAGGAACACGTATAAGCCCATATTCAGGATTTGCGCCCCAATCCACAAATAAACGTATAAGTTCAAGATTATCGCTCTTCACGGCCTTTACTAGCGCCGCTTCAAGACAAAGATCATCCTCAGAAAAACACTGTAAATGTTTATACGAAAAAACTTGCTTACAATTGTTACATAGGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAACGTATAATCATAGTCACTTGAAAGATAATTGCATGCCACAACTTTTTTGGCCAACGTTTGTAAAGACAACAT
SEQ ID No.67–马拉维Lil-20/1(1983)MGF 360 14L(AY261361.1:30193-31266)
TTAGTCTATAACTACAATTTCTGGATGGGCTGTAAAATACTCTTCGGCTTGTTTTAGATTTTTTGACGTATATGTATTTAGCATATCATATATTGCCTGGGGCTCAGTTAGATCTAATATCAAGCTCACATCACGGCTGAAAAGCTGTTTTACTAAAAAAAGGTTGCTCAAGTTATACATATAAACTCTACGCGCAATGAGTCGCGCCCTATCAAAGTTAGTAGCCCCCAAATCAATGCAGAAAAATAGGTTTAAAGTATTATTGTTATAGATAGATAGATTCATGCCATAATCAAGACTAGCCCCTAACATATGACAGTAATAAATGGCTGCATAATTTTCTTCCCGCAAGCAAGCAAATTTCATCATCAGATTAGGGCTAATGCAAATCTCTTTTTTACAACACAGCTCATGCAAGTCAAAAATGTTGTTAAAATAAAGGCTACAAGTCAGTCGCCAATAGAGCTGATTTTTATGCTTTTCGTAGAAATAGTGAATAGCTTTTGTAAAATTATGTCGTAATGCCAGGGCAAACCAAAACTTTGATAATAGGAGGTGCGCCGTATCCCCCGTCAACGGAATTTTTGAACGGGTGTACATAACTGTGTCTAAGGTGGTTCTAGTCACGGTTTCCAAGAGTGGATTATGACAAAACATGTCATAACCCAGTAGAACTCCTGCACAGGATTTCAGATCGGCCACTTCTTTTAAAATCTCCAGAAGACGAGATTCGGATACAGGTGTTAAGCCTCCTAGTTCCATGCACAGCCGCTTTAGATGCACGGCAGGAACACGTATAAGTCCATATTCAGGATTTGCGCCCCAATCCACAAACAATCGTATAAGCTCAAGATTATCGCTCTTCACGGCCTTTACTAGCGCCGCTTCAAGACAAAGATCATCCTCAGAAAAACACTGTAAATGTTTATATGAAAAAATTTGCTTACATGTATTACATAAGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAGCGTATAATCATAATCACTTGAAAGATAATTGCATGCCACAACTTTTTTGGCCAGCGTTTGTAAAGACAACAT
SEQ ID No.68–Mkuzi 1979MGF 360 14L(AY261362.1:33547-34620)
TTAGTCTATAACTATAATTTCTGGATGGGCTGTAAGATACTCTTCGGCCCGTTTCATATTTTTTGAAGTATATGTCTTTAGCATATCATATATTTCCTGGGGTTCGGTTACATCTAATACCAAGGTCACATCACGGCTGAAAAGCTGCTTTACTAAGAAAATGTTGCTCAAGTTATACATATAAGCTTTGTGCGCAATGAGTTGTGCCCTATCAAAATCGGCAGCCCCCAAATCAATACAGAAAAACATGTTTAAAGTATTATTGTTATAGATAGAAAGATTCATGCCATAATCGAGACTAGCCCCCAACCTATGACAGTAATAAATGGCCGCGTAATTTTTTTCCCGCAAGCAAGCAAATTTCATCATCAGATTAGGGCTAATGCAAATCTCTTTTTCACGACACAGCTCGTGTATGTCAAAAATGTTATTAAAATAAAGGCTACAAGCTACCCGCCAATAGAGCTGATTTTTATGCCTTTTATAAAAATAGTGGATAGCCTTTGTAAAATTATGTCGTAATGCCAGGGCAAACCAAAACTTTGTTAATAGGAGGTGCGCCGTATCCCCCGTCAACGGAATGTTTGAACAGGTGTACGTAACTGTGTCTAAAGTGGTTCTAGTTACGGTTTCCAAGAGTGGATTATGACAAAACATGTCATAACCCAGTAGAACTCCTGCACAGGATTTTAGGTTGGCCACTTCTTTTAAAATTTCCAGAAGACGGGGTTCGGATACAGGCGTTAAGCCTCCCAGTTCCGCACACAGCCGCTTTAGATACACGGCAGGAACACGTATAAGCCCATATTCAGGATTTGCGCCCCAATCCACAAATAAACGTATAAGTTCAAGATTATCGCTCTTCACGGCCTTTACTAGCGCCGCTTCAAGACAAAGATCATCCTCAGAAAAACACTGTAAATGTTTATACGAAAAAACTTGCTTACAATTGTTACATAGGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAACGTATAATCATAGTCACTTGAAAGATAATTGCATGCCACAACTTTTTTGGCCAACGTTTGTAAAGACAACAT
SEQ ID No.69–Pretorisuskop/96/4MGF 360 14L(AY261363.1:32525-33598)
TTAGTCTATAACTATAATTTCTGGATGGGCTGTAAGATACTCTTCGGCTCGTTTCAGATTTTTTGAAGTATATGACTTTAGCCTATCATATATTTCCTGGGGTTCGGTTACATCTAATGCCAAGGTCACATCACGGCTGAAAAGCTGCTTTACTAAGAAAATGTTGCTCAAGTTATACATATAAGCTTTGTGCGCAATGTGTTGTGCCCTATCAAAATCAGTAGCCCCCAAATCGATGCAGAAAAACATGTTTAAAGTATTATTGTTATAGATAGAAAGATTCATGCCATAATCGAGACTAGCCCCTAACCTATAACAGTAATAAATGGCCGCATAATTTTTTTTCTGCAAGCAAGCAAATTTCATCATCAGATTAGGGCTGATGCAAATCTCTTTTTCACGACACAGCTCGTGTATGTCAAAAATGTTATTAAAATAAAGGCTACAAGCTACCCGCCAATAGAGGTGATTTTTATGCCTTTTATAGAAATAGTGAATAGCCTTTGTAAAATTATGTCGTAATGCCAGGGCAAACCAAAACTTTGTTAATAGGAGGTGCGCCGTATCCCCCGTCAACGGAATGTTTGAACAGGTGTACGTAACTGTGTCTAAAGTGGTTCTAGTTACGGTTTCCAAGAGTGGATTATGACAAAACATGTCATAACCCAGTAGAACTCCTGCACAGGATTTTAGCTTGGCCACTTCTTTTAAAATTTCCAGAAGACGGGGTTCGGTTACAGGCGTTAAGCCTCCCAGTTCCGTGCACAGCCGCTTTAGATGCACGGCAGGAACACGTATAAGTCCATATTCAGGATTTGCGCCCCAATCCACAAATAAACGTATAAGCTCAAGATTATCGCTCTTCACGGCCTTTACTAGCGCCGCTTCAAGACAAAGATCATCCTCAGAAAAACACTGTAAATGTTTATACGAAAAAATTTGCTTACAATTGTTACACAGGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAACGTATAATCATAGTCACTTGAAAGATAATTGCATGCCACAACCTTTTTGGCCAACGTTTGTAAAGACAACAT
SEQ ID No.70–Tengani 62MGF 360 14L(AY261364.1:26983-28056)
TTAGTCTATAACTATAATTTCTGGATGGGCTGTAAGATACTCTTCAGCTCGTTTCAGATTTTTTGAAGTATATGACTTTAGCATATCATATATTTCCTGGGGTTCGGTTACATCTAATGCCAAGGTCACATCACGGCTGAAAAGCTGCTTTACTAAGAAAATGTTGCTCAAGTTATACATATAAGCTTTGTGCGCAATGCGTTGTGCCCTATCAAAATCAGTAGCCCCCAAATCGATGCAGAAAAACATGTTTAAAGTATTATTGTTATAGATAGAAAGATTCATGCCATAATCGAGACTAGCCCCTAACCTATAACAGTAATAAATGGCCGCATAATTTTTTTTCTGCAAGCAAGCAAATTTCATCATCAGATTAGGGCTGATGCAAATCTCTTTTTCACGACACAACTCGTGTATGTCAAAAATGTTATTAAAATAAAGGCTACAAGCTACCCGCCAATAGAGGTGATTTTTATGCCTTTTATAGAAATAGTGAATAGCCTTTGTAAAATTATGTCGTAATGCCAGGGCAAACCAAAACTTTGTTAATAGGTGGTGCGCCGTATCCCCCGTCAACGGAATGTTTGAACAGGTGTACGTAACTGTGTCTAAAGTGGTTCTAGTTACGGTTTCCAAGAGTGGATTATGACAAAACATGTCATAACCCAGCAGAACTCCTGCACAGGATTTTAGCCTGGCCACTTCTTTTAAAATTTCCAGAAGACGGGATTCGGATACAGGCGTTAAGCCACCCAGTTCCGTGCACAGCCGCTTTAGATGCACGGCAGGAACACGTATAAGTCCATATTCAGGATTTGCGCCCCAATCCACAAATAAACGTATAAGCTCAAGATTATCGCTCTTCACGGCCTTTACTAGCGCCGCTTCAAGACAAAGATCATCCTCAGAAAAACACTGTACATGTTTATACGAAAAAATTTGCTTACAATTATTACATAGGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAACGTATAATCATAGTCACTTGAAAGATAATTGCATGCCACAACCTTTTTGGCCAATGTTTGTAAAGACAACAT
SEQ ID No.71–Warmbaths MGF 360 14L(AY261365.1:31747-32820)
TTAGTCTATAACTATAATTTCTGGATGGGCTGTAAGATACTCTTCGGCTCGTTTCATATTTTTTGAAGTATATGCCTTTAGCCTATCATATATTTCCTGGGGTTCGGTTACATCTAATGCCAAGGTCACATCACGGCTGAAAAGCTGCTTTACTAAAAGAATGTTGCTCAAGTTATACATATAAGCTTTGTGCGCAATGCGTTGTGCCCTATCAAAATCAGTAGCCCCCAAATCGATGCAGAAAAACAGGTTTAAAGAATTATTGTTATAGATAGAAAGATTCATGCCATAATCGAGACTAGCTCCCAACCTATAACAGTAATAAATGGCCGCGTAATTTTTTTCCCGCAAGCAAGCAAATTTCATCATCAGATTAGGGCTAATGCAAATCTCTTTTTCACGACACAGCTCGTGTATGTCAAAAATGTTATTAAAATAAAGGCTACAAGCTACCCGCCAATAGAGGTGATTTTTATGCCTTTTATAGAAATAGTGAATAGCCTTTGTAAAATTATGTCGTAATGCCAGCGCAAACCAAAACTTTGTTAATAGGTGGTGCGCCGTATCCCCCATCAACGGAATTTTTGAACAGCTGTACATAACTGTGTCTAAAGTGGTTCTAGTTATGGTTTCCAAGAGTGGGTTATAACAAAACATGTCATAACCCAGTAGAACTCCTGCACAGGATTTTAGGTTGGCCACTTCTTTTAAAATTTCCAGAAGACGGGGTTCGGATACAGGTGTTAAGCCTCCCAGTTCTGTGCACAGCCGCTTTAGATGCACGGTAGGAACACATATAAGTCCATATTCAGGATTTGCACCCCAATCCACAAATAAACGTATAAGCTCAAGATTATCCCTCTTCACGGCCTTTACTAGCGCCGCTTCAAGACAGAGATCATCCTCAGAAAAACACTGTAAATGTTTATACGAAAAAATTTGCTTACAATTGTTACACAGGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAACATATAATCATAGTCACTTGAAAGATAATTGCATGCCACAACCTTTTTGGCCAACGTTTGTAAAGACAACAT
SEQ ID No.72–Warthog MGF 360 14L(AY261366.1:28495-29568)
TTAGTCTATAACTATAATTTCTGGATGGGCTGTAAGATACTCTTCGGCTCGTTTCAGATTTTTTGAAGTATATGACTTTAGCATATCATATATTTCCTGGGGTTCGGTTACATCTAATGCCAAGGTCACATCACGGCTGAAAAGCTGCTTTACTAAAAAAATGTTGCTCAAGTTATACATATAAGTTTTGTGCGCAATGCGTTGTGCCCTATCAAAATCAGTAGCCCCCAAATCGATGCAGAAAAACATGTTTAAAGTATTATTGTTATAGATAGAAAGATTCATGCCATAATCGAGACTAGCCCCTAACCTATAACAGTAATAAATGGCCGCATAATTTTTTTTCCGCAAGCAAGCAAATTTCATCATCAGATTAGGGCTGATACAAATCTCTTTTTCACGACACAGCTCGTGTATGTCAAAAATGTTATTAAAATAAAGGCTACAAGCTACCCGCCAATAGAGGTGATTTTTATGCCTTTTATAAAAATAGTGAATAGCCTTTGTAAAATTATGTCGTAATGCCAGGGCAAACCAAAACTTTGTTAATAGGTGGTGCGCCGTATCCCCCGTCAACGGAATGTTTGAACAGGTGTACGTAACTGTGTCTAAAGTGGTTCTAGTTACGGTTTCCAAGAGTGGATTATGACAAAACATGTCATAACCCAGTAGAACTCCTGCACAGGATTTTAGCTTGGCCACTTCTTTTAAAATTTCCAGAAGACGGGGTTCGGATACAGGCGTTAAGCCTCCCAGTTCCGTGCACAGCCGCTTTAGATGCACGGCAGGAACACGTATAAGTCCATATTCAGGATTTGCGCCCCAATCCACAAATAAACGTATAAGCTCAAGATTATCGCTCTTCACGGCCTTTACTAGCGCCGCTTCAAGACAAAGATCATCCTCAGAAAAACACTGTAAATGTTTATACGAAAAAATTTGCTTACAATTGTTACATAGGTGAATAGGACCTAAATCCCACCACAAACCAAAACGCTGCAACATATAATCATAGTCACTTGAAAGATAATTGCATGCCACAACCTTTTTGGCCAACGTTTGTAAAGACAACAT
在本发明的减毒ASFV的实施方案中，MGF 360 14L基因的表达和/或活性被破坏。适当地，MGF 360 14L基因包含SEQ ID No.61、62、63、64、65、66、67、68、69、70、71或72的序列。适当地，MGF 360 13L基因包含与SEQ ID No.61、62、63、64、65、66、67、68、69、70、71或72具有至少70％、至少80％、至少90％或至少95％的同一性的序列。适当地，MGF360 14L基因由SEQ ID No.61、62、63、64、65、66、67、68、69、70、71或72的序列组成。
MGF 505 1R基因序列
SEQ ID No.73–贝宁97/1MGF 505 1R(NC_044956.1:21971-23566)
ATGTTCTCTCTCCAGAACTTATGTCGAAAAACATTACCTGACTGTAAACTTCCTGAATTTTTTGACGATTATATATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACTATTCAACGGGCAGGAAACAACTGTGTGCTTATACAACAACATACCCTCATTCCCGTAAATGAAGCCCTAAGAATAGCAGCATCTGAAGAAAATTATGAGATCGTGGGCCTTTTATTAGCGTGGGAGGGGAACCTTTACTATGCTATTATAGGGGCTCTAGAGGGTAACCGCTACAACTTAATTCGTAAATATGATGATCAAATCAAGGACCATCATGACATTCTGCCATTCATTGATGATCCAATCATATTTCACAAATGCCATATCATGCGGCGATGCTTTTTTGATTGTATTTTATATCAAGCTGTAAAATATAGTAAGTTTCGTGTTCTTCTTTATTTTAAATATACATTAGAGGATGATTTGCCCCTCGTTCATTTACTTATTGAAAAGGCATGTGAAGATCATAATTATGAAGTTATTAAATGGATATATGAAAACCTACATGTCTGCCATATAATAGATACCTTTGACTGTGCTATTGCCCATAAAGATCTACGTTTATATTGTTTGGGGTATACATTTATATACAACAGGATTGTACCCTATAAGTATCATCATTTAGATATTCTCATACTTTCAAGCCTACAACTCCTACATAAGGTGGCGGCCAAAGGATACTTAGATTTTATCCTAGAAACCTTAAAGTATGATCATAATATAGATAATTTAGATGTTATTCTAACACAAGCTGCAACATATAACCATAGAAAAATTTTAACCTATTTTATTCCTCAATCAACCTACGCACAAATAGAACAATGTTTGTTCGTGGCGATAAAAACAAAATCTTCCAAGAAAACCTTGAACTTACTACTGTCTCACCTAAACCTTTCCATCAAACTCATCCAAAAAATCAGCCAATATGTTGCCACTTTCAATTCAACAAATATAATAGGCATTCTGAGTATGAAGCGGAAAAAGAAGATATATTTGGATATCATATTGACAAAATTTGTAAAAAATGCTATTTTTAATAAATTTGTCGTTCGATGTATGGAGAGATTTTCTATAAACCCGGAAAGAATCGTCAAAATGGCTGCGCGTATAAATAAGATGATGTTAGTGAAAAAAATATCTGAACATGTTTGGAAAAATCATGCGGCTAGACTTAAACACCTTAAACATGCGGTACACACGATGAAGCATAAAGATGGGAAAAATAGACTCATGAACTTTATCTATGAACACTGCTATTACCATATGCAAGGGGAAGAAATTTTTAGCCTCGCAAGATTTTATGCAATCCATCATGCACCAAAGTTGTTCGACGTTTTTTATAATTGTTGTATCCTAGATACGATACGATTCAAAAGCCTTCTTTTAGATTGTTCACATATCATAGGTAAAAACGCTCATGATGCTACTAATATCAACATCGTGAACAAGTATATTGGCAACCTGTTTGCTATGGGAGTTCTTAGCAAAAAAGAAATCTTACAGGACTATCCATCCATCTATTCTAAACATTATATGCCTTAG
SEQ ID No.74–中国/2018/安徽XCGQ MGF 505 1R(MK128995.1:27736-29331)
ATGTTCTCTCTCCAGAACTTATGTCGAAAAACATTACCTAACCGTAAACTTCCTGAATTTTTTGACGAATATATATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACTATTCAACGAGCAGGAAACAACTGTGTGCTTATACAGCAACATACCCTCATTCCCGTAAATGAAGCCCTGAGAACAGCAGCATCTGAAGAAAATTATGAGATCGTGAGCCTTTTATTAGCGTGGGAGGGGAACCTTTACTATGCTATTATAGGGGCTCTAGAGGGCAACCGCCACGACTTAATTCGTAAATATGATGACCAAATCAAGGACCATCATGAAATTCTGCCATTCATTGACGATCCAGTCATATTTCACAAATGCCATATCATGCGGCAATGCTTTTTTGATTGTATTTTATATCAAGCTGTAAAATATAGTAAGTTTCGCGTTCTTCTTTACTTTAAACATAGATTAGAGGATGATTTGCCCTTCACTCATTTACTTATTGAAAAGGCATGTAAAGATCATAATTATGAAGTTATTAAATGGATATATGAAAACCTACATATCTACAATATGATAGATACCTTTGAATGTGCTATTGCCCATAAGGATCTACATCTATATTGTTTGGGGTATAGATTTATATATAACAGAATCGTACCCGATAAGTATCATCATTTAGATATTCGCATGCTTTCAAGCCTACAACTCCTACATAAGGTGGCAGCCAAAGGATACTTAGATTTTATCCTAGAAACCTTAAAGTATGATCATAATAAAGATAATATAAATATTATTCTAACACAAGCTGCAACCTATAACCATAGAAAAATTTTAATCTATTTCATTCCTCAATCAACCCACGCACAGATAGAACAATGTTTACTAGTGGCGATAAAAGCAAAATCTTCCAGGAAAACCTTGAACTTACTACTGTCTCACCTAAACCTTTCCATCAACCTCATCAAAAAAATAAGCCATTATGTTGCCACTTACAATTCAACAAATATAATAGGCATTCTGAGTATGCGGCGGAAAAAGAAGATATATTTAGATATCATATTGACAAAATTTGTAAAAAAAGCTATTTTTAATAAGTTTGTCGTTCGATGTATGGATACATTTTCTATAAACCCGGAAAGAATCCTTAAAATAGCCGCGCGAATAAATAGGATGATGTTAGTGAAAAAAATATCTGAACATGTTTGGAAAAATCATGCGGTTAGACTTAAATACCTTAAACATGCGGTACACACGATGAAGCATAAAGATGGGAAAAATAGACTCATGAACTTTATCTATGATCGCTGTTATTACCATATGCAAGGGGAAGAAATCTTTAGCCTCGCAAGATTTTATGCAATCCATCATGCACCAAAGTTGTTTGACGTTTTTTATGATTGTTGTATCCTAGATACGATACGATTCAAAAGCCTTCTTTTAGATTGTTCACATATCATAGGTAAAAACGCTCATGATGCTACCAATATCAACATCGTGAACAAGTATATCGGCAACCTGTTTGTTATGGGAGTTCTTAGCAAAAAAGAAATCTTACAGGACTATCCATCCATTTATTCTAAACAATACATGCCTTAG
SEQ ID No.75–格鲁吉亚2007/1MGF 505 1R(LR743116.1:28707-30302)
ATGTTCTCTCTCCAGAACTTATGTCGAAAAACATTACCTAACCGTAAACTTCCTGAATTTTTTGACGAATATATATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACTATTCAACGAGCAGGAAACAACTGTGTGCTTATACAGCAACATACCCTCATTCCCGTAAATGAAGCCCTGAGAACAGCAGCATCTGAAGAAAATTATGAGATCGTGAGCCTTTTATTAGCGTGGGAGGGGAACCTTTACTATGCTATTATAGGGGCTCTAGAGGGCAACCGCCACGACTTAATTCGTAAATATGATGACCAAATCAAGGACCATCATGAAATTCTGCCATTCATTGACGATCCAGTCATATTTCACAAATGCCATATCATGCGGCAATGCTTTTTTGATTGTATTTTATATCAAGCTGTAAAATATAGTAAGTTTCGCGTTCTTCTTTACTTTAAACATAGATTAGAGGATGATTTGCCCTTCACTCATTTACTTATTGAAAAGGCATGTAAAGATCATAATTATGAAGTTATTAAATGGATATATGAAAACCTACATATCTACAATATGATAGATACCTTTGAATGTGCTATTGCCCATAAGGATCTACATCTATATTGTTTGGGGTATAGATTTATATATAACAGAATCGTACCCGATAAGTATCATCATTTAGATATTCGCATGCTTTCAAGCCTACAACTCCTACATAAGGTGGCAGCCAAAGGATACTTAGATTTTATCCTAGAAACCTTAAAGTATGATCATAATAAAGATAATATAAATATTATTCTAACACAAGCTGCAACCTATAACCATAGAAAAATTTTAATCTATTTCATTCCTCAATCAACCCACGCACAGATAGAACAATGTTTACTAGTGGCGATAAAAGCAAAATCTTCCAGGAAAACCTTGAACTTACTACTGTCTCACCTAAACCTTTCCATCAACCTCATCAAAAAAATAAGCCATTATGTTGCCACTTACAATTCAACAAATATAATAGGCATTCTGAGTATGCGGCGGAAAAAGAAGATATATTTAGATATCATATTGACAAAATTTGTAAAAAAAGCTATTTTTAATAAGTTTGTCGTTCGATGTATGGATACATTTTCTATAAACCCGGAAAGAATCCTTAAAATAGCCGCGCGAATAAATAGGATGATGTTAGTGAAAAAAATATCTGAACATGTTTGGAAAAATCATGCGGTTAGACTTAAATACCTTAAACATGCGGTACACACGATGAAGCATAAAGATGGGAAAAATAGACTCATGAACTTTATCTATGATCGCTGTTATTACCATATGCAAGGGGAAGAAATCTTTAGCCTCGCAAGATTTTATGCAATCCATCATGCACCAAAGTTGTTTGACGTTTTTTATGATTGTTGTATCCTAGATACGATACGATTCAAAAGCCTTCTTTTAGATTGTTCACATATCATAGGTAAAAACGCTCATGATGCTACCAATATCAACATCGTGAACAAGTATATCGGCAACCTGTTTGTTATGGGAGTTCTTAGCAAAAAAGAAATCTTACAGGACTATCCATCCATTTATTCTAAACAATACATGCCTTAG
SEQ ID No.76–Ken05/Tk1 MGF 505 1R(NC_044945.1:29657-31249)
ATGTTCTCTCTCCAAAACTTATGTCGAAAAACCTTACCTGACTGTAAACTTCCTGAATTTTTTGACGATTATGTATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACGATTCAACGAGCAGGAAACAACTGTGTACTTATCCAACAACATAACCTCATTCCCGTAAATGAAGCCCTAAGAATAGCAGCATCTGAAGAAAATTATGAGATCGTGAGCCTTTTATTAGCGTGGGAGGGGAACCTTTACTATGCTATTATAGGGGCTCTAGAGGGTAACCGCCACAACTTAATTCGTAAATATGATGACCAAATCAAGGACCATCATGAAATTCTGCCATTTATTGACGATCCAGTTATATTTCACAAATGTCATATAATGCGGCGATGCTTTTTTAATTGTATGTTGTATCAAGCTGTAAAATATAGTAAGTTTAGCGTTCTTCTATATTTTAAATATATATTAAAGGAAAATTTGCCCCTCGTCCACTCACTCATTGAAAAAGCGTATAAATATCATAATTATGAGGTTATTAAATGGATCTATGAAAATCTACATATCTATGATATCATAAATACTTTTAAATATGCTATTGCCCATAAAGATCTACGTTTATATTGTTTAGGGTATACATTTGTATATAATAGGATCGTACCCTATAAGTATTATCATTTAGATATTCGCATCCTTTTAAGGCTACAACTTCTACATAAGGTGACAGCCAAAGGATACTTGGATTTTATCCTAGAAACCTTAAAGTATGATCATAATACAAACAATATAGATATTATCCTAACACAGGCTGCAACCTATAACCATAGAAACATTTTAACCTATTTCATTCCTCAATCAACCTACGCACAAATAGAACAATGCTTATTCGTGGCAATAAAAACAAACGCTTCCAAAAAAACCTTGAATTTACTATTATCTCACCTAAACCTTTCTATCAAACTCGTCAAAAAATTAAGCCAATATGTTGTCGCTTACAAGTCAACAAATATCATAAGCATTCTGAGTATGCAGCAAAAAAAGAAGATATATTTAGATATCATTTTGACAAAGGTTGTAAAAAACGCTGTTTTTATTAAATTTGTCATTGGATGTATGGTTACATTTTCCATAAACCCAGAAAGAATTGTCAAAATGGCCGCGCGAATAAAAAAGATGAAGTTAGTAAAAAATATATCTGAACATGTTTGGAAAAATCATGCGGCTAAACTTAAACATCTTAAGCATGCGGTACACACGATGAAGCATCAAGAAGGAAAAAATAGACTCATGAACTTTATCTATGATCACTGCTATTACCACATGCAAGGAGAAGAGATCTTTAGTCTTGCAAGATTTTATGCAATCCATCATGCGCCAAAATTGTTCGACGTTTTTTATGATTGTTGTATCCTAGATACGATACGATTTAAAAGCCTGCTTTTAGATTGTTCACATATTATAGCTAAAAACGCTCATGATGCTAGTATTAACATCGTGAATAAGTATATTGGCAATCTATTTGCTATGGGAGTTCTTAGCAAAAAAGAAATCTTACAAGACTATCCATCCATCTATTCTAAATATGACATACTTTAG
SEQ ID No.77–Ken06.Bus MGF 505 1R(NC_044946.1:25784-27376)
ATGTTCTCTCTCCAGAACTTATGTCGAAAAACCTTACCTGACTGTAAACTTCCTGAGTTTTTTGACGATTATGTATTACAACTGCTGGGCTTATACTGGGAAAATCATGGTACGATTCAACGAGCAGGAAACAACTGTGTACTTATCCAACAACATAACCTCATTCCCGTAAATGAAGCCCTAAGAATAGCAGCATCTGAGGAAAATTATGAGATCGTGAGCCTTTTATTAGCGTGGGAGGGGAACCTTTACTATGCTATTATAGGGGCTCTAGAGGGGAACCACCACAACTTAATTCGTAAATACGATGACCAAATCAAGGACCATCATGAAATTCTGCCATTTATTGACGATCCAGTCATATTTCACAAATGTCATACAATGCGGCGATGCTTTTTTAATTGTATTTTATATCAAGCTGTAAAATATAGTAAGTTCAGCGTTCTTCTATACTTTAAATATATATTAAAGGAGAATTTGCCCCTCGTCCACTCACTTATTGAAAAGGCGTATAAATATCATAATTATGAGGTTATTAAATGGATCTATGAAAACCTACATATCTATGATATCATAAATACTTTTAAATGTGCTATTGCCCATAAAGATCTACGTTTATATTGTTTAGGGTATACATTTGTATATAATAGAATCGTACCCTATAAGTATTATCATTTAGATATTCGCATCCTTTTAAGGCTACAACTTCTACATAAGGTGACAGCCAAAGGATACTTGGATTTTATCCTAGAAACCTTAAAGTATGATCATAATACAAACAATATAGATATTATCCTAACACAGGCTGCAACCTATAACCATAGAAACATTTTAACCTATTTCATTCCTCAATCAACCTACGCACAAATAGAACAATGTTTATTCGTGGCGATAAAAACAAATGCTTCCAAGAAAACCTTGAATTTACTATTATCTCACCTAAATCTTTCTATCAAACTCGTCAAAAAATTAAGCCAATATGTTGTCGCTTACAAGTCAACAAATATCATAAGCATTCTGAGTAGGCAGCAAAAAAAGAAGATATATTTAGATATCATTTTGACAAAGGTTGTAAAAAATGCTGTTTTTAATAAATTTGTCATTGGATGTATGGTTACATTTTCCATAAACCCAGAAAGAATTGTCAAAATGGCCGCGCGAATAAAAAAGATGAAGTTAGTAAAAAATATATCTGAACATGTTTGGAAAAATCATGCGGTTAAACTTAAATATCTTAAGCATGCGGTACACACGATGAAGCATCAAGAAGGAAAAAATAGATTAATGAACTTTATCTATGATCACTGTTATTACCACATGCAAGAAGAAGAGATCTTTAGCCTCGCAAGATTTTATGCAATCCATCATGCGCCAAAATTGTTCGACGTTTTTTATGATTGTTGTATCCTAGATACGATACGATTTAAAAGCCTGCTTTTAGATTGTTCACATATCATAGTTAAAAACGCTCATGATGCTAGTATTAACATCGTGAACAAGTATATTGGCAATCTATTTGCTATGGGAGTTCTTAGCAAAAAAGAAATCTTACAAGACTATCCATCTATCTATTCTAAGGATTACATGCTTTAG
SEQ ID No.78–肯尼亚1950MGF 505 1R(AY261360.1:31904-33496)
ATGTTTTCTCTCCAGAACTTATGTCGAAAAACCTTACCTGACCGTAAACTTCCTGAATTTTTTGACGATTATGTATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACGATTCAACGAGCAGGAAACAACTGTGTACTTATCCAACAACATAACCTCATTCCCGTAAATGAAGCCCTAAGAATAGCAGCATCTGAAGAAAATTATGAGATCGTGAGCCTTTTATTAGCTTGGGAGGGGAACCTTTACTATGCTATTATAGGGGCTCTAGAGGGTAATCGCCACAACTTAATTCGTAAATATGATGACCAAATCAAGGACCATCATGAAATTCTGCCATTTATTGACGATCCAGTCATATTTCACAAATGTCATATGATGCGGCGATGCTTTTTTAATTGTATTTTGTATCAAGCTGTAAAATATAGTAAGTTTAGCGTTCTTCTATATTTTAAATATATATTAAAGGAGAATTTGCCCCTCGTTCATTCACTTATTGAAAAGGCGTGTGAAGATCATAATTATGAAGTTATTAAATGGATCTATGAAAACCTACATATCTATGAAATAATGGATACCTTTAAATGTGCTATTGCCCATAAAGATCTACATTTATATAGTTTAGGATATACATTTATATATAATAGGATCGTACCCTATAAGTATCATCATTTAGATATTCGCATACTTTCAAGGCTACAACTTCTACATAAGGTGACAGCCAAAGGATACTTGGACTTTATCCTAGAAACCTTAAAGTATGATCATAATAAAGATAATATAAATATTATTCTGACACAAGCTGCAACCTATAACCATAGAAACATTTTAACCTATTTCATTCCTCAATCAACCTACGCGCAGATAGAACAATGCTTATTCGTGGCAATAAAAACAAACGCTTCCAAGAAAACCTTGAATTTACTATTATCTCACCTAAACCTTTCTATCAAACTCGTCAAAAAATTAAGCCAATATGTTGTTGCTTACAAGTCAACAAATATCATAAGCATTCTGAGTATGCAGCAAAAAAAGAAGATATATTTAGATATCATTTTGACAAAGGTTGTAAAAAACGCTATTTTTATTAAATTTGTCATTGGATGTATGGTTACATTTTCCATAAACCCAGAAAGAATTGTCAAAATGGCCGCGCGAATAAAAAAGATGAAGTTAGTGAAAAATATATCTGAACATGTTTGGAAAAATCATGCGGCTAAACTTAAACACCTTAAGCATGCGGTACACACGATGAAGCATCAAGAAGGAAAAAATAGATTAATGAACTTTATCTATGATCACTGTTATTACCACATGCAAGGAGAAGAGATCTTTAGTCTTGCAAGATTTTATGCAATCCATCATGCGCCAAAATTGTTCGACGTTTTTTATGATTGTTGTATCCTAGATACGATACGATTTAAAAGCCTGCTTTTAGATTGTTCATATATCATAGCTAAAAACGCTCATGATGCTAGTATTAACATCGTGAATAAGTATATTGGCAATCTATTTGCTATGGGGGTTCTTAGCAAAAAAGAAATCTTACAAGACTATCCATCCATCTATTCTAAGGATTACATGCTTTAG
SEQ ID No.79–L60 MGF 505 1R(NC_044941.1:22320-23915)
ATGTTCTCTCTCCAGAACTTATGTCGAAAAACATTACCTGACTGTAAACTTCCTGAATTTTTTGACGATTATATATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACTATTCAACGGGCAGGAAACAACTGTGTGCTTATACAACAACATACCCTCATTCCCGTAAATGAAGCCCTAAGAATAGCAGCATCTGAAGAAAATTATGAGATCGTGGGCCTTTTATTAGCGTGGGAGGGGAACCTTTACTATGCTATTATAGGGGCTCTAGAGGGTAACCGCTACAACTTAATTCGTAAATATGATGATCAAATCAAGGACCATCATGACATTCTGCCATTCATTGATGATCCAATCATATTTCACAAATGCCATATCATGCGGCGATGCTTTTTTGATTGTATTTTATATCAAGCTGTAAAATATAGTAAGTTTCGTGTTCTTCTTTATTTTAAATATACATTAGAGGATGATTTGCCCCTCGTTCATTTACTTATTGAAAAGGCATGTGAAGATCATAATTATGAAGTTATTAAATGGATATATGAAAACCTACATGTCTGCCATATAATAGATACCTTTGACTGTGCTATTGCCCATAAAGATCTACGTTTATATTGTTTGGGGTATACATTTATATACAACAGGATTGTACCCTATAAGTATCATCATTTAGATATTCTCATACTTTCAAGCCTACAACTCCTACATAAGGTGGCGGCCAAAGGATACTTAGATTTTATCCTAGAAACCTTAAAGTATGATCATAATATAGATAATTTAGATGTTATTCTAACACAAGCTGCAACATATAACCATAGAAAAATTTTAACCTATTTTATTCCTCAATCAACCTACGCACAAATAGAACAATGTTTGTTCGTGGCGATAAAAACAAAATCTTCCAAGAAAACCTTGAACTTACTACTGTCTCACCTAAACCTTTCCATCAAACTCATCCAAAAAATCAGCCAATATGTTGCCACTTTCAATTCAACAAATATAATAGGCATTCTGAGTATGAAGCGGAAAAAGAAGATATATTTGGATATCATATTGACAAAATTTGTAAAAAATGCTATTTTTAATAAATTTGTCGTTCGATGTATGGAGAGATTTTCTATAAACCCGGAAAGAATCGTCAAAATGGCTGCGCGTATAAATAAGATGATGTTAGTGAAAAAAATATCTGAACATGTTTGGAAAAATCATGCGGCTAGACTTAAACACCTTAAACATGCGGTACACACGATGAAGCATAAAGATGGGAAAAATAGACTCATGAACTTTATCTATGAACACTGCTATTACCATATGCAAGGGGAAGAAATTTTTAGCCTCGCAAGATTTTATGCAATCCATCATGCACCAAAGTTGTTCGACGTTTTTTATAATTGTTGTATCCTAGATACGATACGATTCAAAAGCCTTCTTTTAGATTGTTCACATATCATAGGTAAAAACGCTCATGATGCTACTAATATCAACATCGTGAACAAGTATATTGGCAACCTGTTTGCTATGGGAGTTCTTAGCAAAAAAGAAATCTTACAGGACTATCCATCCATCTATTCTAAACATTATATGCCTTAG
SEQ ID No.80–马拉维Lil-20/1(1983)MGF 505 1R(AY261361.1:26041-27633)
ATGTTCTCTCTCCAGAACTTATGTCGAAAAACATTACCTGACTGTAAACTTCCTGAATTTTTTGACGAATATATATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACTATTCAACGAGCAGGAAACAACTGTGTGCTTATCCAGCAACATAACCTTATTCCCGTAAATGAAGCCCTAAGAATAGCAGCATCTGAAGAAAATTATGAGATCGTGAGCCTTTTATTAGCGTGGGAGGGAAACCTTTACTATGCTATTATAGGGGCTCTAGAGGGCAACCGCCCCGACTTAATTCGTAAATATGATGACCAAATCAAGGACCATCATGAAATTTTGCCATTCATCGACGATCCAATCATATTTCACAAATGTCACATAATGCGGCGATGCTTTTTTAATTGTATTTTATATCAAGCTGTAAAATATAGTAAGTTTCGTGTTCTTCTTTATTTTAAACATAGGTTAGGGGATGATTTGCCCCTCACTCATTTACTTATTGAAAAGGCATGTGAAGATCATAATTATGAAGTTATTAAATGGATCTATGAAAACCTACATAGCTACAATATAATGGATACCTTTGAATGTGCTATTGCCCATAAGGATCTACGTCTATATTGTTTGGGGTATACATTTATATATAATAGGATCGTACCCTATAAGTATCATCATTTAGATATTTGCATACTTTCAAGCCTACAACTCCTGCATAAGGTGGCAGCCAAAGGATACTTGGATTTTATCCTAGAAACCTTAAAGTATGATCATAACATAAATAATATAGATATTATTCTAACACAAGCTGCAACCTATAACCATAGAAAAATTTTAACCTATTTCATTCCTCAATTAACCTACGCACAGATAGAACAATGTTTACTAGTGGCGATAAAAACAAAAGCTTCCAAGAAAACCTTGAACTTACTACTGTCTCACCTAAACCTTTCCATCAAACTCATCAAAAAAATAAGCCAATATGTTGTCACTTACAATTCAACAAATATCATAAGCATTCTGAGTATGCGGCGGAAAAAGAAGATATATTTAGATATCATTTTGACAGAGTTTGTAAAAAACGCTATTTTTAATAAATTTGTCGTTCGATGTATGGATACATTTTCCATAAACCCGGAAAGAATTGTCAAAATGGCCGCACGAATAAATAGGATGATGTTAGTGAAAAATATATCTGAACGTGTTTGGAAAAATCATGCGGTTAAACTTAAACACCTTAAGCATGCGGTACATACGATGAAGCATCAAGAAGGAAAAAATAGACTCATGAACTTTATCTATGATCACTGCTATTACCACATGCAAGGGGAAGAGATCTTTGGCCTCGCAAGATTTTATGCAATCCATCATGCACCCAAGTTGTTTGACGTTTTTTATGATTGCTGCATGCTAGATGCTACACGATTTAAAAGCCTGCTTTTAGATTGTCCACATATCATAGGTAAAAACGCTTATGATGCTGGTATCAACCTCGTGAACAAATATATTGGCAACCTATTTGCTATGGGGGTTCTTAGCAAAAAAGAAATCTTACAGGACTATCCATCTATCTATTCTAAACATGATATGTTTTAG
SEQ ID No.81–Mkuzi 1979 MGF 505 1R(AY261362.1:29425-31020)
ATGTTCTCTCTCCAGAACTTATGTCGAAAAACATTACCTGATTGTAAACTTCCTGAATTTTTTGACGATTATATATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACTATTCAACGGGCAGGAAACAACTGTGTGCTTATACAGCAACATACCCTTATTCCCATAAATGAAGCCCTGAGAACAGCAGCATCTGAAGAAAATTATGAGATCGTGAGCCTTTTATTAGCATGGGAGGGGAATCTTTACTATGCTATTATAGGGGCTCTAGAGGGCAACCGCCACGACTTAATTCGTAAATATGATGACCAAATCAAGGACCATCATGAAATTCTGCCATTCATTGACGATCCAGTAATATTTCACAAATGCCATATCATGCGGCGATGCTTTTTTGATTGTATTTTATATCAAGCTGTAAAATATAGTAAGTTTCGCGTTCTTCTTTATTTTAAATATAGGTTAGAGGATGATTTACCCCTCACTCATTTACTTATTGAAAAGGCATGTGAAAATCATAATTATGAAGTTATTAGATGGATATATGAAAACCTACATATCTACAATATGATAGATACCTTTGAATGTGCTATTGCCCATAAGGATCTACGTCTATATTGTTTGGGGTATACATTTATATATAACAGGATCGTACCCAATAAGTATCATCATATAGATATTCTCATTCTTTCAAGCCTACAACTCCTGCATAAGGTGGCAGCCAAAGGATACTTAGACTTTATCCTAGAAACCTTAAAGTATGATCATAACAATGATAATTTAGATATTATTCTAACACAAGCTGCAACATATAACCATAGAAAAATTTTAACCTATTTTATTCCTCAATCAACCTACGCACAAATAGAACAATGTTTGATGGTGGCGATAAAAACAAAATCTTCCAAGAAAACCTTGAATTTACTATTGTCCCACCTAAACCTTTCCATCAAACTCATCAAAAAAATAAGCCAATATGTTGTCACTTACAATTCAACAAATATAATAGGCATTCTGAGTATGAAGCGAAAAAAGAAGATATATTTAGATATCTTGTTGACAAAATTTGTAAAAAATGCTATTTTTAATAAATTTGTCGTTCGATATATGGATACGTTTTCTATAAACCCGGAAAAAATCGTCAAAATGGCCGCGCGAATAAATAAGATGATGTTAGTGAAAAAAATATCTGAACATATTTGGAAAAATCATGCGGCTAGACTTGAACACCTTAAACATGCGGTACACACGATGAAGCATAAAGATGGGAAAAATAGACTCATGAACTTTATCTATGAGTACTGCTATTACCATATGCAAGGGGAAGAAATTTTTAGCCTCGCAAGATTTTATGCAATCCATCATGCACCAAAGTTGTTCGACGTTTTTTATAATTGTTGTATCCTAGATACGATACGATTCAAAAGCCTTCTTTTAGATTGTTCACATATCATAGGTAAAAACGCTCATGATGCTACTAATATCAACATCGTGAACAAGTATATTGACAACCTGTTTGCTATGGGAGTTCTTAGCAAAAAAGAAATCTTACAGGACTATCCATCCATTTATTCTAAACATTATATGCCTTAG
SEQ ID No.82–Pretorisuskop/96/4 MGF 505 1R(AY261363.1:28449-30044)
ATGTTCTCTCTCCAGAACTTATGTCGAAAAACATTACCTGACTGTAAACTTCCTGAATTTTTTGACGAATATATATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACTATTCAACGAGCAGGAAACAACTGTGTGCTTGTACAACAACATACCCTCATTCCCGTAAACGAAGCCCTGAGAATAGCAGCGTCTGAAGAAAATTATGAGATCGTGAGCCTTTTATTAGCGTGGGAGGGAAACCTTTACTATGCTATTATAGGAGCTCTAGAGGGCAACCGCCACGACTTAATTCGTAAATATGATGACCAAATCAAGGACCATCATGAAATTCTGCCATTCATTGACAATCCAGTCATATTTCACAAATGCCATATAATGCGGCGATGCTTTTTTGATTGTATTTTATATCAAGCTGTAAAATATAGTAAGTTTCGCGTTCTTCTTTATTTTAAATATAGGTTAGAGAATGATTTGCCCCTCGCTCATTTACTTGTTGAAAAGGCATGTGAAGATCATAATTATGAAGTTATTAAATGGTTATATGAAAACCTACATATCTACAATATAATGGAGACCTTTGAATGTGCTATTGCCCATAAGGATCTACGTCTATATCGTTTGGGGTATACATTTATATATAACAGGATCGTACCCTATAAGTATCATTATTTAGATGTTCTCATTCTTTCAGGCCTACATCTCCTGTATAAGGTGGCAGCCAAAGGATACTTAGATTTTATCCTAGAAACCTTAAAGTATGATCATAACAATGATAATTTAGATATTATTCTAACACAAGCTGTAACATATAACCATAGAAAAATTTTAACCTATTACATTCCTCAATTAACCTATGCACAAATAGAACAATGTTTGTTCATGGCGATTAAAAAAAAATCTTCCAAGAAAACCTTGAACTTACTACTGTCTCACCTAAAGCTTTCCATCAAACTCATCAAAAAAATAAGCCAATATGTTGCCACTTACAATTCAACAAATATAATAGGCATTCTGAATATGAAGCGGAAAAAGAAGATATATTTAGATATCATATTGACAAAATTTGTAAAATACGCTATTTTTAATAAATATGTCGTTCGTTGTATGGATACATTTTCCATAAACCCGGAAAGAATCATCAAAATGGCCGCGCGAATAAATAAGATGTTGTTAGTGAAAAAAATATCTCAACATGCTTGGAAAAATCATGCGGCTAGACTTAAACACCTTAAGCATGCGGTATACACGATGAAACATAAAGATGGGAAAAATAGACTCATGAACTTGATCTATGATCACTACTATTACCATATGCAAGGGGAAGAAATCTTTAGCCTCGCAAGATTTTATGCAATCCATCATGCACCAAAGTTGTTTGACGTTTTTTATGATTGTTGTCTCCTAGATACTATACGATTTAAAAGCCTTCTTTTAGATTGTTCACACATCATAGGTAAAAACGCTCATGATGCTACTAATATCACTATCGTGAACAAGTATATTGGCAACCTGTTTGCTATGGGAGTTCTTAGCAAAAAAGAAATCTTACAGGACTATCCATCCATCTATTCTAAACATTACATGCCTTAG
SEQ ID No.83–Tengani 62 MGF 505 1R(AY261364.1:22891-24486)
ATGTTCTCTCTTCAGAACCTATGTCGAAAAACATTACCTGACTGTAAACTTCCTGAATTTTTTGACGAATATATATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACTATTCAACGAGCAGGAAACAACTGTGTGCTTATACAGCAACATAACCTCATTCCCGTAAATGAAGCCCTAAGAATAGCAGCATCTGAAGAAAATTATGAGATCGTGAGTCTTTTATTAGCATGGGAGGGGAACCTTTACTATGCTATTATAGGGGCTCTAGAGGGCAACCGCCACGACTTAATTCGTAAGTATGATGACCAAATCAAGGACCATCATGAAATTCTGCCATTCATTGACGATCCAGTAATATTTCACAAATGCCATATCATGCGGCAATGCTTTTTTGATTGTATTTTATATCAAGCTGTAAAATATAGTAAGTTTCGCGTTCTTCTTTCTTTTAAACATAGATTAAGGGATGATTTGCCCTTCACTCATTTACTTATTGAAAAGGCATGTAAAGATCATAATTATGAAGTAATTAAATGGATATATGAAAACCTACATATCTACAATATGATAGATACCTTTGAATGTGCTATTGCCCATAAGGATCTACGTCTATATTGTTTGGGGTATAGATTTATATATAACAGGATCGTACCCGATAAGTATCATCATTTAGATATTCGCATGCTTTCAAGCCTACAACTCCTGCATAAGGTGGCAGCCAAAGGATACTTAGATTTTATCCTAGAAACCTTAAAGTATGATCATAATAAAGATAATATAAATATTATTCTAACACAAGCTGCAACCTATAACCATAGAAAAATTTTAATCTATTTCATTCCTCAATCAACCCACGCACAGATAGAACAATGTTTACTAGTGGCGATAAAAACAAAATCTTCCAAGAAAACCTTGAACTTACTACTGTCTCACCTAAACCTTTCCATCAATCTCATCAAAAAAATAAGCCATTATGTTGCCACTTACAATTCAACAAATATAATAGGCATTCTGAGTATGCGGCGGAAAAAGAAGATATATTTAGATATCATATTGACAAAATTTGTAAAAAAAGCTATTTTTAATAAATTTGTCGTTCGATGTATGGATACATTTTCTATAAACCCGGAAAGAATCCTTAAAATAGCCGCGCGAATAAATAGGACGATGTTAGTGAAAAAAATATCTGAACATGTTTGGAAAAATCATGCGGTTAGACTTAAATACCTTAAACATGCGGTACACACGATGAAGCATAAAGATGGGAAAAATAGACTCATGAACTTTATCTATGATCGCTGTTATTACCATATGCAAGGGGAAGAAATCTTTAGCCTCGCAAGATTTTATGCAATCCATCATGCACCAAAGTTGTTTGACGTTTTTTATGATTGTTGTATCCTAGATACGATACGATTCAAAAGCCTTCTTTTAGATTGTTCACATATCATAGGTAAAAACGCTCATGATGCTACCAATATCAACATCGTGAACAAGTATATCGGCAACCTGTTTGTTATGGGAGTTCTTAGCAAAAAAGAAATCTTACAGGACTATCCATCCATCTATTCTAAACATTACATGCCTTAG
SEQ ID No.84–Warmbaths MGF 505 1R(AY261365.1:27651-29246)
ATGTTCTCTCTCCAGAACCTATGTCGAAAAACTTTACCTGACTGTAAACTTCCTGAATTTTTTGACGAATATATATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACTATTCAACGAGCAGGAAACAACTGTGTGCTTATACAGCAACGTACCCTCATTCCCGTAAATGAAGCCCTGAGAATAGCAGCATCTGAAGAAAATTATGAGATCGTGGGCCTTTTATTAGCGTGGGAGGGGAACCTTTACTATGCTATTATAGGAGCTCTAGAGGGCAACCGCCACGACTTAATTCGTAAATATGATGACCAAATCAAGGACCATCATGAAATTCTGCCATTCATTGACGATCCAGTCATATTTCACAAATGCCATATAATCCGACGATGCTTTTTTAATTGTATTTTATATCAAGCTGTAAAATATAGTAAGTTTCGCGTTCTTCTTTACTTTAAACATAGATTAGAGGATGATTTGCCCCTCACTCATTTACTTATTGAAAAGGCATGTGAAGATCATAATTATGAAGTTATTAAATGGATATATGAAAACCTACATACCTACGATATAATGGATACCTTTGAATGTGCTATTGCCCATAAGGATCTACGTCTATATTGTTTGGGGTATACATTTATATATAACAGGATCGTACCCTATGAGTATCATCATTTAGATATTCTCATTCTTTCAAGCCTACAACTCCTGCATAAGGTGGCAGCCAAAGGATACTTAGATTTTATCCTAGAAACCTTAAAGTATGATCATAACAATGATAATTTAGATATTATTCTAACACAAGCTGCAACATATAACCATAGAAAAATTTTAACCTATTTCATTCCTCAATTAACCTACGCACAAATAGAACAATGTTTGTTCATGGCGATAAAAAGAAAATCTTCCAAGAAAACCTTGAACTTACTACTGTCTCACCTAACCCTTTCCATCGAACTCATCAAAAAAATAAGCCAATATGTTGTCACTTACAATTCAACAAATATAATAGGCATTCTGAGTATGAAGCGGAAAAAGAAGATATATTTAGATATCATGTTGACAAAATATGTAAAATACGCTATTTTTAATAAATATGTCGTTCGATGTATGGATAGATTTTCCATAAACCCGGAAAGAATCATCAAAATGGCCGCGCGAATAAATAGGATGATGTTAGTGAAAAAAATATCTGAACATGTTTGGAAAAATCATGCGGCTAGACTTAAACACCTTAAGCATGCGGTACACACGATGAAGCATAAAGATGGGAAAAATAGACTCATGAACTTTATCTATGATCGCTGCTATTACCATATGCAAGGGGAAGAAATCTTTAGCCTCGCAAGATTTTATGCAATCCATCATGCACCAAAGTTGTTTGACGTTTTTTATGATTGTTGTATCCTAGATACTATACAATTCAAAAGCCTTCTTTTAGATTGTTCACATATCATAGGTAAAAACGCTCATGATGCTACCAATATCAACATCGTGAACAAGTATATTGGCGACCTGTTTGCTATGGGAGTTCTTAGCAAAAAAGAAATCTTACAGGACTATCCATCCATCTATTCTAAACATTACATGCTTTAG
SEQ ID No.85–Warthog MGF 505 1R(AY261366.1:24387-25982)
ATGTTTTCTCTCCAGAACTTGTGTCGAAAAACATTACCTGACTGTAAACTTCCTGAATTTTTTGACGAATATATATTACAACTGCTGGGATTATACTGGGAAAACCATGGAACTATTCAACGAGCAGGAAACAACTGTGTGCTTATACAGCAACATACCCTCATTCCCGTAAACGAAGCCCTGAGAATAGCAGCATCTGAAGAAAATTATGAGATCGTGAGCCTTTTATTAGCGTGGGAGGGAAACCTTTACTATGCTATTATAGGAGCTCTAGAGGGCAACCGCCACGACTTAATTCGTAAATATGATGACCAAATCAAGGACCATCATGAAATTCTGCCATTCATTGACGATCCAGTCATATTTCACAAATGCCATATCATGCGGCGATGCTTTTTTGATTGTATTTTATATCAAGCTGTAAAATATAGTAAGTTTCGCGTTCTTCTTTATTTTAAATATAGGTTAGAGAATGATTTGCCCCTCGCTCATTTACTTATTAAAAAGGCATGTGAAGATCATAATTATGAAGTTATTAAATGGATATATGAAAACCTACATATCTACAATATAATGGATACCTTTGGATGTGCTATTGCCCATAAGGATCTACGTCTATATCGTTTGGGGTATACATTTATATATAACAGGATCGTACCCTATAAGTATCATTATTTAGATGTTCTCATTCTTTCAGGCCTACATCTCCTGTATAAGGTGGCAGCCAAAGGATACTTAGATTTTATCCTAGAAACCTTAAAGTATGATCATAACAATGATAATTTAGATATTATTCTAACACAAGCTGCAACATATAACCATAGAAAAATTTTAACCTATTACATTCCTCAATTAACCTATGCACAAATAGAACAATGTTTGTTCATGGCGATTAAAAAAAAATCTTCCAAGAAAACCTTGAACTTACTACTGTCTCACCTAAAGCTTTCCATCAAACTCATCAAAAAAATAAGCCAATATGTTGCCACTTACAATTCAACAAATATAATAGGCATTCTGAATATGCGGCGGAAAAAGAAGATATATTTAGATATCATATTGACAAAATTTGTAAAAAAAGCTATTTTTAATAAATTTGTCGTTCGATGTATGGATACATTTTCCATAAACCCGGAAAGAATCATCAAAATGGCCGCGCGAATAAATAAGATGTTGTTAGTGAAAAAAATATCTGAACATGCTTGGAAAAATCATGCGGCTAGACTTAAACACCTTAAGCATGCGGTATACACGATGAAACATAAAGATGGGAAAAATAGACTCATGAACTTGATCTATGATCACTACTATTACCATATGCAAGGGGAAGAAATCTTTAGCCTCGCAAGATTTTATGCAATCCATCATGCACCAAAGTTGTTTGACGTTTTTTATGATTGTTGTCTCCTAGATACTATACGATTTAAAAACCTTCTTTTAGATTGTTCACACATCATAGGTAAAAACGCTCATGATGCTACTAATATCACTATCGTGAACAAGTATATTGGCAACCTGTTTGCTATGGGAGTTCTTAGCAAAAAAGAAATCTTACAGGACTATCCATCCATCTATTCTAAACATTACATGCCTTAG
在本发明的减毒ASFV的实施方案中，MGF 505 1R基因的表达和/或活性被破坏。适当地，MGF 505 1R基因包含SEQ ID No.73、74、75、76、77、78、79、80、81、82、83、84或85的序列。适当地，MGF 505 1R基因包含与SEQ ID No.73、74、75、76、77、78、79、80、81、82、83、84或85具有至少70％、至少80％、至少90％或至少95％的同一性的序列。适当地，MGF 505 1R基因由SEQ ID No.73、74、75、76、77、78、79、80、81、82、83、84或85的序列组成。
MGF 505 2R基因序列
SEQ ID No.86–贝宁97/1MGF 505 2R(NC_044956.1:27352-28932)
ATGTTTTCCCTTCAAGACCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTACTACAACGATTAGGACTGTATTGGAGATGTCACGGCTCCCTTCAACGCATAGGAGACGACCACATACTCATACGACGGGATCTCATCCTTTCCACCAACGAGGCCTTAAGAATGGCGGGAGAGGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGAAGGGAAATCTTCATTACGCCGTCATAGGAGCCCTGCAGGGTGATCAATATGACCTGATCCATAAGTATGAAAACCAAATCGGCGACTTTCATTTTATCTTACCATTGATTCAAGACGCGAATACGTTTGAAAAATGCCACGCTTTAGAACGTTTTTGTGGTGTTTCATGTCTGCTAAAACATGCTACAAAATACAACATGCTCCCTATTCTCCAAAAATACCAAGAAGAGCTGTCTATGAGAGCGTATCTTCACGAAACCCTATTTGAACTAGCATGCCTATGGCAGAGGTATGATGTCCTTAAATGGATAGAGCAGACCATGCATGTTTACGACCTAAAGATTATGTTTAATATTGCCATCTCCAAGAGGGATCTGACTATGTACTCCTTAGGATATATTTTCCTTTTTGATAGAGGGAACACCGAAGCTACGTTGCTAACGCAACATCTCGAGAAGACAGCGGCCAAAGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGCAACATAGATACCGTCCTGACCCAAGCCGTAAAGTACAACCATAGAAAACTTTTAGATTATTTTCTGCGTCAACTACCTCGTAAACATATTGAAAAGCTTTTGTTGCTGGCTGTTCAGGAAAAGGCTTCTAAAAAAACATTGAACTTACTGTTGTCACATTTAAACTACTCCGTGAAACGCATCAAAAAACTGCTGCGCTATGTGATAGAGTATGAGTCCACCTTGGTGATAAAGATTTTGTTAAAAAAAAGAGTAAACCTGATAGATGCCATGTTGGAAAAGATGGTAAGATATTTTTCTGCGACGAAAGTGAGGACGATCATGGATGAGCTTTCGATTAGTCCGGAAAGAGTCATTAAGATGGCTATACAGAAAATGAGAACGGATATCGTAATCCATACTTCTTATGTTTGGGAGGATGATCTAGAACGTCTTACTCGTCTTAAAAATATGGTATACACCATAAAGTACGAACATGGGAAAAAAATGTTAATTAAAGTCATGCACGGCATATACAAAAACTTATTATACGGCGAAAGGGAAAAAGTCATGTTTCATTTAGCCAAGCTCTATGTTGCTCAAAATGCGGCCACCCAATTCAGAGACATTTGTAAGGACTGTTACAAACTGGATGTGGCACGGTTTAAACCGCGGTTTAAGCAACTAATATTAGACTGTTTAGAAATTGTTACTAAAAAATCTTGCTATAGTATCCTGGAAATCTTAGAAAAACATATTATTTCCCTATTTACTATGAAAGTTATGACTGAAGAAGAAAAAAACCTATGTTTAGAAATATTATATAAAGTAATTCATTATAAAACAATACAATGTTAA
SEQ ID No.87–中国/2018/安徽XCGQ MGF 505 2R
ATGTTTTCCCTTCAAGACCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTACTACAACGATTAGGACTGTATTGGAGATGTCACGGCTCCCTTCAACGCATAGGAGACGACCACATACTCATACGACGGGATCTCATCCTTTCCACCAACGAGGCCTTAAGAATGGCGGGAGAGGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGAAGGGAAATCTTCATTACGCCGTCATAGGAGCCTTGCAGGGTGATCAATATGACCTGATCCATAAGTATGAAAACCAAATCGGCGACTTTCATTTTATCTTACCATTGATTCAAGACGCGAATACGTTTGAAAAATGCCACGCTTTAGAACGTTTTTGTGGTGTTTCATGTCTGCTAAAACATGCTACAAAATACAACATGCTCCCTATTCTCCAAAAATACCAAGAAGAGCTGTCTATGAGAGCGTATCTTCACGAAACCCTATTTGAACTAGCATGCCTATGGCAGAGGTATGATGTCCTTAAATGGATAGAGCAAACCATACATGTTTACGACCTAAAGATTATGTTTAATATTGCCATCTCCAAGAGGGATCTGACTATGTACTCCTTAGGATATATTTTCCTTTTTGATAGAGGGAACACCGAAGCTACGTTGCTAACGCAACATCTCAAGAAGACAGCGGCCAAAGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGCAACATAGATACCGTCCTGACCCAAGCCGTAAAGTACAATCATAGAAAACTTTTAGATTATTTTCTGCGTCAACTACCTCGTAAACATATTGAAAAACTTTTGTTGCTGGCCGTGCAGGAAAAGGCTTCTAAAAAAACATTGAACTTACTGTTGTCACATTTAAACTACTCCGTGAAACGCATCAAAAAACTACCGCGCTATGTGATAGAGTACGAGTCCACCTTGGTGATAAAGATTTTATTAAAAAAAAGAGTGAACCTGATAGATGCCATGTTGGAAAAGATGGTAAGATATTTTTCTGCGACGAAAGTGAGGACGATCATGGATGAGCTTTCGATTAGTCCGGAAAGAGTCATTAAGATGGCTATACAGAAAATGAGAACGGATATCGTAATCCATACTTCTTATGTTTGGGAGGATGATCTAGAACGTCTTACTCGTCTTAAAAATATGGTATACACCATAAAGTACGAACATGGGAAAAAAATGTTAATTAAAGTCATGCACGGCATATACAAAAACTTATTATACGGCGAAAGGGAAAAAGTCATGTTTTATTTAGCCAAGCTCTATGTTGCTCAAAACGCGGCCACCCAATTCAGAGACATTTGTAAGGACTGTTACAAACTGGATGTGGCACGGTTTAAACCGCGGTTTAAGCAACTAATATTAGACTGTTTAGAAATTATTACTAAAAAATCTTGCTATAGTATCCTGGAAATCTTAGAAAAACATATTATTTCCCTGTTTACTATGAAAGTTATGACTGAAGAAGAAAAAAACCTATGTTTAGAAATATTATATAAAGTAATTCATTATAAAACAATACAATGTTAA
SEQ ID No.88–格鲁吉亚2007/1MGF 505 2R(NC_044959.1:33119-34699)
ATGTTTTCCCTTCAAGACCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTACTACAACGATTAGGACTGTATTGGAGATGTCACGGCTCCCTTCAACGCATAGGAGACGACCACATACTCATACGACGGGATCTCATCCTTTCCACCAACGAGGCCTTAAGAATGGCGGGAGAGGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGAAGGGAAATCTTCATTACGCCGTCATAGGAGCCTTGCAGGGTGATCAATATGACCTGATCCATAAGTATGAAAACCAAATCGGCGACTTTCATTTTATCTTACCATTGATTCAAGACGCGAATACGTTTGAAAAATGCCACGCTTTAGAACGTTTTTGTGGTGTTTCATGTCTGCTAAAACATGCTACAAAATACAACATGCTCCCTATTCTCCAAAAATACCAAGAAGAGCTGTCTATGAGAGCGTATCTTCACGAAACCCTATTTGAACTAGCATGCCTATGGCAGAGGTATGATGTCCTTAAATGGATAGAGCAAACCATACATGTTTACGACCTAAAGATTATGTTTAATATTGCCATCTCCAAGAGGGATCTGACTATGTACTCCTTAGGATATATTTTCCTTTTTGATAGAGGGAACACCGAAGCTACGTTGCTAACGCAACATCTCAAGAAGACAGCGGCCAAAGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGCAACATAGATACCGTCCTGACCCAAGCCGTAAAGTACAATCATAGAAAACTTTTAGATTATTTTCTGCGTCAACTACCTCGTAAACATATTGAAAAACTTTTGTTGCTGGCCGTGCAGGAAAAGGCTTCTAAAAAAACATTGAACTTACTGTTGTCACATTTAAACTACTCCGTGAAACGCATCAAAAAACTACCGCGCTATGTGATAGAGTACGAGTCCACCTTGGTGATAAAGATTTTATTAAAAAAAAGAGTGAACCTGATAGATGCCATGTTGGAAAAGATGGTAAGATATTTTTCTGCGACGAAAGTGAGGACGATCATGGATGAGCTTTCGATTAGTCCGGAAAGAGTCATTAAGATGGCTATACAGAAAATGAGAACGGATATCGTAATCCATACTTCTTATGTTTGGGAGGATGATCTAGAACGTCTTACTCGTCTTAAAAATATGGTATACACCATAAAGTACGAACATGGGAAAAAAATGTTAATTAAAGTCATGCACGGCATATACAAAAACTTATTATACGGCGAAAGGGAAAAAGTCATGTTTTATTTAGCCAAGCTCTATGTTGCTCAAAACGCGGCCACCCAATTCAGAGACATTTGTAAGGACTGTTACAAACTGGATGTGGCACGGTTTAAACCGCGGTTTAAGCAACTAATATTAGACTGTTTAGAAATTATTACTAAAAAATCTTGCTATAGTATCCTGGAAATCTTAGAAAAACATATTATTTCCCTGTTTACTATGAAAGTTATGACTGAAGAAGAAAAAAACCTATGTTTAGAAATATTATATAAAGTAATTCATTATAAAACAATACAATGTTAA
SEQ ID No.89–Ken05/Tk1 MGF 505 2R(NC_044945.1:35094-36674)
ATGTTTTCCCTTCAAGACCATTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTACTACAACGGTTAGGACTGTACTGGGGACGTCACGGCTCTCTTCAACGAATCGGGGACGATCACATACTCATACGGCGGGACCTCATCCTTTCCACCAACGAGGCCTTAAAAATGGCGGGAGAAGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGGAGGGAAATCTTCATTATGCTATCATAGGGGCTTTACAGGGTGATCAATATGACCTAATCCATAAGTATGAAAACCAAATCGAAGACTATCATCATATCTTACCATTGATTCAAGATGCGGAAACGTTTGAAAAATGCCACGCCTTAGAACGTTTTTGTGATGTTCCATGTCTGCTAGAACATGCTACAAAACACAACATGCTCCCTATTCTCCAAAAATATCAAGAAGAGTTGTCTATAAGAGTGTATCTACGCGAAACCCTATTCGAACTAGCATGCCTATGGCAGAGGTATGATATTCTTAAATGGATAGAGCAAACCATGCATGTTTACGATCTAAAAATTATATTTAATATTGCCATCTCCAAGAGGGATCTAAGCATGTACTCCTTAGGATATGTTCTCCTTTTTGATAGAGGGAACACCGAAGCTACCTTGTTAACGCAACACCTCGAGAAGACAGCGGCCAAGGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGTAACTTAAATATCGTCCTGTTCCAAGCCGTAAAATACAATCATAGAAAACTTTTAGATTATTTTCTGCGTCAACTACCCCGTAAAAATATTGAAAAACTTTTGTTGCTGGCTGTGCAGGAAAAAGCTTCTAAGAAAACATTGAACTTACTGTTGTCACATTTAAACTACTCCGTGAAACGCATCAAAAAACTGCTGCGCTATGTGATAGAGTACGAGTCTACCTTGGTGATAAAGATTTTATTAAAAAAAAGAGTAAACCTAATAGACGCCGTGTTGGAAAAGACTGTAAGATATTTTTCTGAGACGAAAGTAAAGACTATTATGGATGAGCTTTCGATTAATCCGGAAAAAGTCATTAAGATGGCCATACAGAAAATGAGAACGGATATTGTGATCCAAACTTCTTATATTTGGGAGGATGATCTAGAAAGACTTATTCGTCTTAAAAATATGGTATACACCATAAAGTATGAACATGGGAAAAAAATGTTAATGAAAGTTATTCACGGCATATACAAAAACTTATTACACGATGAAAAAGAAAAAGTCATGTTTCATTTAGCCAAGTTCTATATTGCTCAAAACGCGGCCACCCAATTCAGAGACATTTGTAAAGACTGTTGCAAACTGGATGTGGCGCGGTTTAAACCGCGGTTTAAACAACTAATTTTAGACTGTTTAGAAATTGTTACTAAAAAATCTTGCTTTAGTATTATAGAAATTTTAGAAAACCATATTATTTCCCTATTTATGATGAAAGTTATCACTGAAGATGAAAAAAACCTAGGTTTAGAATTATTATATAAAGTAATTAGTTACAAAATGATATCATATTAA
SEQ ID No.90–Ken06.Bus MGF 505 2R(NC_044946.1:31225-32799)
ATGTTTTCCCTTCAAGACCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTACTACAACAATTGGGGCTGTACTGGGAAAAACACGGCTCTCTTCAACGAATAGGGAACGATCACATACTCATACGGCGGGATCTCATCCTTTCTATCAACGAGGCCTTAAAAATAGCGGCAGAGGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGAAGGGAAATCTTCATTATGCCATCATAGGAGCCTTGCAGGGTGACCAATATGACCTCATCCATACGTACGAAAACCAAATCGAAGACTATCATCATATCTTGCCATTGATTCAAGATGCGAAAACGTTTGAAAAATGCCACGCCTTGGAACGTTTTTGTGATGTTCCATGCCTACTAGAACATGCTACAAAACACAACATGCTCCCTATTCTCCAAAAATACCAAGAAGAGCTGTTTATAAGAGTGTATCTCCGCGAAACCCTATTTGAACTAGCATGCCTATGGCAGAGGTATGATATCCTTAAATGGATAGAGCAAACCATGCATGTTTACGACCTAAAGATTATGTTTAATATTGCCATCTCCAAGAGGGATCTAAGCATGTACTCTTTAGAATATATTCTCTTTTTTAATAGAGGGAACACCGATGTTGCGTTAGCAACGTTGCTAACGCAACATCTCGAGAAGACAGCGGCCAAGGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGTAACATAAACATCGTCCTCTCCCAAGCCGTAAAATACAATCATAGAAAACTTTTAGATTATTTTCTGCGTCAACTACCTCGTAAAAATATTGAAAAACTTTTGTTGCTGGCCGTACAGGAAAGGGCTTCTAAGAAAACATTGAACTTACTGTTGTCTTATTTAAACTACTCCGTGAAACGCATCAAAAAACTGCTGCGCTATGTGATAGAGCATGAGTCCACACTGGTGATAAGGATTTTATTAAAAAAAAGAATAAACCTAATAGACGCCGTGTTGGAAAAGACTGTAAGATATTTTTCTATGACTAAAGTGAGGACGATCATGGATGAGCTTTCGATTAATCCGGAAAAAGTCATTAAAATGGCCGTGCAGAAAATGAGAACGGATATCGTGATCCATACTTCTTATGTTTGGGAGGATGATCTAGAAAGACTTATTCGTCTTAAAAATATGCTATACACTATAAAGTATGAGCATGGAAAAAAAATGCTAATTAAAGTCATTCACGGCATATACAAAAACTTATACGGCGAAAAAGAAAAAGTCATGTTTAATTTGGCCAAGTTCTATGCTGCTCAAAACGCGGCCACCCAATTCAAAGACACTTGTAAAGACTGTTGCAAACTGGATGTGGCGCGGTTTAAACAACTAATTTTAGACTGTTTAGACATTATTACTAAAAAAACGTGCCTCAGTATCATGGAAATCTTAGAAAATCATATTATTTCGCTATTTGCTATGAAAATGATGACGGAGGATGAAAAAAACTTAGGTTTAGAAATATTATATAAAGTAATTAGTTACAAAATGATATCATATTAA
SEQ ID No.91–肯尼亚1950MGF 505 2R(AY261360.1:37419-38999)
ATGTTTTCCCTTCAAGACCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCACGTACTACAACAATTGGGGCTGTACTGGGAAAAACACGGCTCTCTTCAACGAATAGGGAACGATCACATACTCATACGGCGGGATCTCATCCTTTCTATCAACGAGGCCTTAAAAATAGCGGCAGAGGAAGGAAACAATGAAGTAGTAAAGCTTTTGTTACTATGGAAGGGAAATCTTCATTATGCCATCATAGGAGCTTTGGAGGGTGACCAATATGACCTGATCTATACGTATGAAAACCAAATTGAAGACTATCATCATATCTTGCCATTGATTCAAGATGCGAAAACGTTTGAAAAATGCCACGCCTTGGAACGTTTTTGTGATGTTCCATGCCTGCTAGAGCATGCTATAAAACACAACATGCTCCCTATTCTCCAAAAATATCAAGAAGAACTGTTTATAAGAGTGTATCTCCGCGAAACCCTATTTGAACTAGCATGCCTATGGCAGAGGTATGATATTCTTAAATGGATAGAGCAAACCATGCATGTTTACGATCTAAAAATTATATTTAATATTGCCATCTCCAAGAGGGATCTAAGCATGTACTCCTTAGGATATGTTCTCCTTTTTGATAGAGGGAACACCGAAGCTACCTTGTTAACGCAACACCTCGAGAAGACAGCGGCCAAGGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGTAACATAAACATCGTCCTATCCCAAGCCGTAAAATACAATCATAGGAAACTTTTAGATTATTTTCTGCGTCAACTACCTCGTAAAAATATTGAAAAACTTTTGTTGTTAGCCGTACAGGAAAAGGCTTCTAAGAAAACATTGAACTTACTGTTGTCTTATTTAAACTACTCCGTGAAACGCATCAAAAAACTGCTGCGCTATGTGATAGAGTACGAGTCCACACTGGTGATAAGGATTTTATTAAAAAAAAGAATAAACCTAATAGACGCCGTGTTGGAAAAGACTGTAAGATATTTTTCTGAGACGAAAGTAAAGACTATTATGGATGAGCTTTCGATTAATCCGGAAAAAGTTATTAAGATGGCCATACAGAAAATGAGAACGGATATTGTGATCCAAACTTCTTATATTTGGGAGGATGATCTAGAAAGACTTATTCGTCTTAAAAATATGGTATACACCATAAAGTATGAACATGGGAAAAAAATGTTAATGAAAGTTATTCACGGCATATACAAAAACTTATTACACGATGAAAAAGAAAAAGTCATGTTTCATTTAGCCAAGTTCTATATTGCTCAAAACGCGGCCACCCAATTCAGAGACATTTGTAAAGACTGTTGCAAACTGGATGTGGCGCGGTTTAAACCGCGGTTTAAACAACTAATTTTAGACTGTTTAGATATTATTACTAAAAAAACGTGCCTCAATATTATGGAAATCTTAGAAAATCATATTATTTCGCTATTTGCTATGAAAATGATGACTGAAGATGAAAAAAACCTAGGTTTAGAATTATTATATAAAGTAATTAGTTACAAAATGATATCATATTAA
SEQ ID No.92–L60 MGF 505 2R(NC_044941.1:27701-29281)
ATGTTTTCCCTTCAAGACCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTACTACAACGATTAGGACTGTATTGGAGATGTCACGGCTCCCTTCAACGCATAGGAGACGACCACATACTCATACGACGGGATCTCATCCTTTCCACCAACGAGGCCTTAAGAATGGCGGGAGAGGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGAAGGGAAATCTTCATTACGCCGTCATAGGAGCCCTGCAGGGTGATCAATATGACCTGATCCATAAGTATGAAAACCAAATCGGCGACTTTCATTTTATCTTACCATTGATTCAAGACGCGAATACGTTTGAAAAATGCCACGCTTTAGAACGTTTTTGTGGTGTTTCATGTCTGCTAAAACATGCTACAAAATACAACATGCTCCCTATTCTCCAAAAATACCAAGAAGAGCTGTCTATGAGAGCGTATCTTCACGAAACCCTATTTGAACTAGCATGCCTATGGCAGAGGTATGATGTCCTTAAATGGATAGAGCAGACCATGCATGTTTACGACCTAAAGATTATGTTTAATATTGCCATCTCCAAGAGGGATCTGACTATGTACTCCTTAGGATATATTTTCCTTTTTGATAGAGGGAACACCGAAGCTACGTTGCTAACGCAACATCTCGAGAAGACAGCGGCCAAAGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGCAACATAGATACCGTCCTGACCCAAGCCGTAAAGTACAACCATAGAAAACTTTTAGATTATTTTCTGCGTCAACTACCTCGTAAACATATTGAAAAGCTTTTGTTGCTGGCTGTTCAGGAAAAGGCTTCTAAAAAAACATTGAACTTACTGTTGTCACATTTAAACTACTCCGTGAAACGCATCAAAAAACTGCTGCGCTATGTGATAGAGTATGAGTCCACCTTGGTGATAAAGATTTTGTTAAAAAAAAGAGTAAACCTGATAGATGCCATGTTGGAAAAGATGGTAAGATATTTTTCTGCGACGAAAGTGAGGACGATCATGGATGAGCTTTCGATTAGTCCGGAAAGAGTCATTAAGATGGCTATACAGAAAATGAGAACGGATATCGTAATCCATACTTCTTATGTTTGGGAGGATGATCTAGAACGTCTTACTCGTCTTAAAAATATGGTATACACCATAAAGTACGAACATGGGAAAAAAATGTTAATTAAAGTCATGCACGGCATATACAAAAACTTATTATACGGCGAAAGGGAAAAAGTCATGTTTCATTTAGCCAAGCTCTATGTTGCTCAAAATGCGGCCACCCAATTCAGAGACATTTGTAAGGACTGTTACAAACTGGATGTGGCACGGTTTAAACCGCGGTTTAAGCAACTAATATTAGACTGTTTAGAAATTGTTACTAAAAAATCTTGCTATAGTATCCTGGAAATCTTAGAAAAACATATTATTTCCCTATTTACTATGAAAGTTATGACTGAAGAAGAAAAAAACCTATGTTTAGAAATATTATATAAAGTAATTCATTATAAAACAATACAATGTTAA
SEQ ID No.93–马拉维Lil-20/1(1983)MGF 505 2R(AY261361.1:31541-33121)
ATGTTTTCCCTTCAAGATCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTACTACAACAGTTAGGACTGTACTGGAAACGTCACGGCTCTCTTCAACGCATAGGAGACGACCACATACTCATACGGCGGGACCTCATCCTTTCCACCAACGAGGCCTTAAAAATGGCGGGAGAGGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGGAGGGAAACCTTCATTATGCCATCATAGGGGCCTTACAGGGTGATCAATATGATCTGATCCATAAGTATGAAAACCAAATCGAAGACTATCATCATATCTTGCCATTGATTCAAGATGCGAAAACGTTTGAAAAATGCCACGCCTTAGAACGTTTTTGTGATGTTCCATGTCTGCTAGAACATGCTACAAAACACAACATGCTCCCTATTCTCCAAAAATACCAAGAAGAGCTGTCTATAAGAGTGTATCTTCGCGAAACCCTATTCGAACTAGCATGCCTATGGCAGAGGTATGATGTTCTTAAATGGATAGAGCAAACCATGCATGTTTACGACCTAAAGATTATGTTTAATATTGCCATCTCCAAGAGGGATCTAAGCATGTACTCCTTAGGATATGTTCTCCTTTTTGATAGAGGAAACATCGAAGCTACGTTCCTAACGCAACATCTCGAGAAGACAGCGGCCAAAGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGTAACTTAAATATCGTCCTGTCCCAAGCCGTAAAATACAATCATAGAAAACTTTTGGATTATTTTCTGCGTCAACTACCTCGTAAAAATATTGAAAAACTTTTGTTGCTGGCCGTGCAGGAAAAGGCTTCTAAAAAAACATTGAACCTACTGTTGTCACACTTAAACTACTCCGTGAAACACATCAAAAAACTGCTGCGCTATGTGATAGAGTACGAGTCTACCTTGGTGATAAAACTTTTATTGAAAAAAAGAGTAAACCTGATAGACGCCGTGTTGGAAAAGAATGTAAGATATTTTTCTGCGATTAAAGTGAGGACTATTATGGATGAGCTTTCGATTAGTCCGGAAAGAGTCATTAAGATGGCCATACAGAAAATGAGAACGGATATTGTGATTCAGACTTCTTATATTTGGGAGGATGATCTAGAAAGACTTATTCGTCTTAAAAATATGGTATACACCATAAAGTATGAACATGGGAAAAAAATGTTAATTAAAGTTATTCACGGCATATACAAAAACTTATTATACGGCGAAAAAGAAAAAGTCATGTTTCATTTAGCCAAACTCTATGTTGCTCAAAACGCGGCCACCCAATTCAGGGACATTTGTAAGGACTGTTGCAAACTGGATGTGGCGCGGTTTAAACCGCGGTTTAAACAACTAATTTTAGACTGTTTAGAAATGGTTACTAAAAAATCTTGCTTTAGTATTATAGAAATCTTAGAAAACTATATTATTTCCCTATTTGTGATGAAAGTCATCACTGAAGAAGAAAAAAACCTATGTTTAGAACTATTATATAAAGTAATTAGTTACAAAACGATATAATGTTAA
SEQ ID No.94–Mkuzi 1979MGF 505 2R(AY261362.1:34826-36406)
ATGTTTTCCCTTCAAGACCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTACTACAACGATTAGGACTGTATTGGAGATGTCACGGCTCCCTTCAACGCATAGGAGACGACCACATACTCATACGACGGGATCTCATCCTTTCCACCAACGAGGCCTTAAGAATGGCGGGAGAGGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGAAGGGAAATCTTCATTACGCCGTCATAGGAGCCTTGCAGGGTGATCAATATGACCTGATCCATAAGTATGAAAACCAAATCGGCGACTTTCATTTTATCTTACCATTGATTCAAGACGCGAATACGTTTGAAAAATGCCACGCTTTAGAACGTTTTTGTGGTGTTTCATGTCTGCTAAAACATGCTACAAAATACAACATGCTCCCTATTCTCCAAAAATACCAAGAAGAGCTGTCTATGAGAGCGTATCTTCACGAAACCCTATTTGAACTAGCATGCCTATGGCAGAGGTATGATGTCCTTAAATGGATAGAGCAGACCATGCATGTTTACGACCTAAAGATTATGTTTAATATTGCCATCTCCAAGAGGGATCTGACTATGTACTCCTTAGGATATATTTTCCTTTTTGATAGAGGGAACACCGAAGCTACGTTGCTAACGCAACATCTCGAGAAGACAGCGGCCAAAGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGCAACATAGATACCGTCCTGACCCAAGCCGTAAAGTACAATCATAGAAAACTTTTAGATTATTTTCTGCGTCAACTACCTCGTAAACATATTGAAAAACTTTTGTTGCTGGCTGTTCAGGAAAAGGCTTCTAAAAAAACATTGAACTTACTGTTGTCACATTTAAACTACTCCGTGAAACGCATCAAAAAACTGCTGCGCTATGTGATAGAGTATGAGTCCACCTTGGTGATAAAGATTTTGTTAAAAAAAAGAGTAAACCTGATAGATGCCATGTTGGAAAAGATGGTAAGATATTTTTCTGCGACAAAAGTGAGGACGATCATGGATGAGCTTTCGATTAGTCCGGAAAGAGTCATTAAGATGGCTATACAGAAAATGAGAACGGATATCGTAATCCATACTTCTTATGTTTGGGAGGATGATCTAGAACGTTTTACTCGTCTTAAAAATATGGTATACACCATAAAGTACGAACATGGGAAAAAAATGTTAATTAAAGTCATGCACGGCATATACAAAAACTTATTATACGGCGAAAGGGAAAAAGTCATGTTTCATTTAGCCAAGCTCTATGTTGCTCAAAATGCGGCCACCCAATTCAGAGACATTTGTAAGGACTGTTACAAACTGGATGTGGCACGGTTTAAACCGCGGTTTAAGCAACTAATATTAGACTGTTTAGAAATTGTTACTAAAAAATCTTGCTATAGTATCCTGGAAATCTTAGAAAAACATATTATTTCCCTATTTACTATGAAAGTTATGACTGAAGAAGAAAAAAACCTATGTTTAGAAATATTATATAAAGTAATTCATTATAAAACAATACAATGTTAA
SEQ ID No.95–Pretorisuskop/96/4 MGF 505 2R(AY261363.1:33795-35374)
ATGTTTTCCCTTCAAGACCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTACTACAACGATTAGGACTGTATTGGAGATGTCACGGCTCCCTTCAACGCGTAGGAGACGACCACATCCTCATACGGCGGGATCTCATCCTTTCCACCAACGAGGCCTTAAGAATGGCGGGAGAAGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGAAGGGAAATCTTCATTACGCCATCATAGGAGCCTTGCAGGGTGATCAATATGACCTGATCCATAAGTATGAAAACCAAATCGGCGACTTTCATCTTATCTTACCATTGATTCAAGATGCGAAAACGTTTGAAAAATGCCACGCTTTAGAACGTTTTTGTGGTGTTTCATGTCTGCTAGAACATGCTACAAAATACAACATGCTCCCTATTCTCCAAACATACCAAGAAGAGCTGTCTATGAGAGCATATCTTCGCGAAACCCTATTTGAACTAGCGTGCCTGTGGCAGAGGTATGATGTCCTTAAATGGATAGAGCAAACCATGCATGTTTACGACCTAAAGATTATGTTTAATATTGCCATCTCCAAGAGGGATCTGACGATGTATTCCTTAGGATATATTCTTCTTTTTGATAGAGAGAACACCGAAGCTACGTTGTTAACACAACATCTCGAGAAGACAGCGGCCAAAGGGCTCCTCTACTTTGTGCTAGAAACGTTAAAATACGGCGGTAACATAGATATCGTCCTGACTCAAGCCGTAAAGTACAATCATAGAAAACTTTTAGATTATTTTCTGCGTCAACTACCTCGTAAACATATTGAAAAGCTTTTGTTGCTGGCCGTGCAGGAAAAGGCTTCTAAAAAAACATTGAACTTACTGTTGTCCCATCTAAACTACTCCGTGAAACGTATCAAAAAACTGCTGCGCTATGTGATAGAGTACGAGTCCACCTTGGTGATAAAGATTTTATTAAAAAAAAGAGTAAACCTGATAGATGCCATGTTGGAAAAGATGGTAAGATATTTTTCTGCGACGAAAGTGAGGACGATCATGGATGAGCTTTTGATTAGTCCGGAAAGAGTCATTAAGATGGCTATACAGAAAATGAGAACGGATATCGTAATCCATACTTCTTATGTTTGGGAGGATGATCTAGAACGACTTACTCGTCTTAAAAATATGGTATACACCATAAAGTACGAACATGGGAAAAAAATGTTAATTAAAGTCATGCACGGCATATACAAAAACTTATTATACGACGAAAGAGAAAAGGTCATGTTTCATTTAGCCAAGCTCTATGTTGCTCAAAACGCGGCCACCCAATTCAGAGACATTTGTAAGGACTGTTACAAACTGGATGTGGCACGGTTTAAACCGCGGTTTAAGCAACTAATGTTAGACTGTTTAGAAATTGTTACTAAAAAATCTTGCTATAGTATCCTGGAAATCTTAGAAAAACATATTATTTCCCTATTTACTATGAAAGTTATGACTGAAGAGGAAAAAAACCTATGTTTAGAAATATTATATAAGTAA
SEQ ID No.96–Tengani 62 MGF 505 2R(AY261364.1:28261-29830)
ATGTTTTCCCTTCAAGACCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTACTACAACGATTAGGACTGTATTGGAGATGTCACGGCTCCCTTCAACGCGTAGGAGACGACCACATACTCATACGGCGGGATCTCATCCTTTCCACCAACGAGGCCTTAAGAATGGCGGGAGAGGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGAAGGGAAATCTTCATTACGCCGTCATAGGAGCCTTGCAGGGTGATCAATATGACCTGATCCATAAGTATGAAAACCAAATCGGCGACTTTCATCTTATCTTACCATTGATTCAAGACGCGAAAACGTTTGAAAAATGCCATGCTTTAGAACGTTTTTGTGGTGTTTCATGTCTGCTAAAACATGCTACAAAATACAACATGCTCCCTGTTCTCCAAAAATACCAAGAAGAGCTGTCCATGAGAGCATATCTTTGCGAAACCCTATTTGAACTAGCATGCCTATGGCAGAGGTATGATGTCCTTAAATGGATAGAGCAAACCATGCATGTTTACGACCTAAAGATTATGTTTAATATTGCCATCTCCAAGAGGGATCTGACTATGTACTCCTTAGGATATATTTTCCTTTTTGATAGAGGGAACACCGAAGCTACGTTGCTAACGCAATATCTCGAGAAGACAGCGGCCAAAGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGTAACATAGATATTGTCCTGACCCAAGCCGTAAAGTACAATCATAGAAAACTTTTAGATTATTTTCTGCGTCAACTACCTCGTAAACATATTGAAAAGCTTTTGTTGCTGGCCGTGCAGGAAAAGGCTTCTAAAAAAACATTGAACTTACTGTTGTCACATTTAAACTACTCCGTGAAACGCATCAAAAAACTGCTGCGCTATGTGATAGAGTACGAGTCCACCTTGGTGATAAAGATTTTATTAAAAAAAAGAGTAAACCTGATAGATGCCATGTTGGAAAAGATGGTAAGATATTTTTCTGCGACGAAAGTGAGGACGATCATGGATGAGCTTTTGATTAGTCCGGAAAGAGTCATTAAGATGGCTATACAGAAAATGAGAACGGATATCGTAATCCATACTTCTTATGTATGGGAGGATGATCTAGAACGACTTACTCGTCTTAAAGATATGGTATACACCGTAAAGTACGAACATGGGAAAAAAATGTTAATTAAAGTCATACACGGCATATACAAAAACTTATTATACGGCGAAAAAGAAAAGGTCATGTTTCATTTAGCCAAGCTCTATGTTGCTCAAAACGCGGCCACCCAATTCAGAGACATTTGTAAGGACTGTTACAAACTGGATGTGGCACGGTTTAAACCGCGGTTTAAGCAACTAATGTTAGACTGTTTAGAAATTGTTACTAAAAAATCTTGCTATAGTATTCTGGAAATCTTAGAAAAACATATGATTTCCCTATTTACTATGAAAGTTATGACTGAAGAAGAAAAAAACCTATGTTTAGAAATATTATATAAGTAA
SEQ ID No.97–Warmbaths MGF 505 2R(AY261365.1:33029-34597)
ATGTTTTCCCTTCAAGACCTTTGCCGAAAGCATCTTTTTATTCTTCCCGATGTTTTTGGCGAGCATGTATTACAACGATTAGGACTGTATTGGAGATGTCACGGCTCCCTTCAACGCGTAGGAGACGACCACATACTCATACGGCGGGATCTCATCCTTTCCACCAACGAGGCCTTAAGAATGGCGGGAGAAGAAGGAAACAATGAAGTAGTAAAGCTCTTGTTACTGTGGAAGGGAAATCTTCATTACGCCATCATAGGAGCCTTGCAGGGTGATCAATATGACCTAATCCATAAGTATGAAAACCAAATCGGCGACTTTCATCTTATCTTACCATTGATTCAAGATGCGAAAACGTTTGAAAAATGCCACGCTTTAGAACGTTTTTGTGGTGTTTCATGTCTGCTAAAACATGCTACAAAATACAACATGCTCCCTATTCTCCAAACATACCAAGAAGAGCTGTCTATGAGAGTATATCTTCGCGAAACCCTATTTGAACTAGCATGCCTATGGCAGAGGTATGATGTCCTTAAATGGATAGAGCAAACCATGCATGTTTACGACCTAAAGGTTATGTTTAATATTGCCATCTCCAAGAGAGATCTGACTATGTATTCCTTAGGATATATTCTTCTTTTTGATAGAGAGAACACCGAAGCTACGTTGCTAACGCAACATCTCGAGAAAACAGCGGCCAAGGGGCTCCTCCACTTTGTGCTAGAAACGTTAAAATACGGCGGTAACATAGATATCGTCCTGTCCCAAGCCGTAAAGTACAATCATAGAAAACTTTTAGATTATTTTCTGCGTCAACTACCTCGTAAAAATATTGAAAAACTTTTGTTGCTGGCTGTTCAGGAAAAGGCTTCTAAAAAAACATTGAACTTACTGTTGTCCCATTTAAACTACTCCGTGAAACGCATCAAAAAACTGCTGCGCTATGTGATAGAGTACGAGTCCACCTTGGTGATAAAGATTTTATTAAAAAAAAGAGTAAACCTGATAGATGCCATGTTGGAAAAGATGGTAAGATATTTTTCTGCGACGAAAGTGAGGACGATCATGGATGAGCTTTCGATTAGTCCGGAAAGAGTCATTAAGATGGCTATACAGAAAATGAGAACAGATATCGTAATCCATACTTCTTATGTTTGGGAGGATGATCTAGAACGACTTACTCGTCTTAAAAATATGGTATACGCCATAAAGTATGAACATGGGAAAAAAATGTTAATGAAAGTCATGCACGGCATATACAAAAACTTATTATACGGCGAAAGAGAAAAGGTCATGTTTCATTTAGCCAAGCTCTATGTTGCTCAAAACGCGGCCACCCAATTCAGAGACATTTGTAAGGACTGTTACAAACTGGATGTGGCACGGTTTAAGCAACTAACGTTAAACTGTTTAGAAATTATTACTAAAAAATCTTGCTATAGTATCCTGGAAATCCTAGAAAAACATATTATTTCCCTATTTACTATGAAAGTTATGACTGAAGAAGAAAAAAACCTATGTTTAGAAATATTATATAAAGTAATTCATTATAATACAATACAATGTTAA
在实施方案中，本发明的减毒ASFV包含MGF 505 2R的功能形式。适当地，MGF 5052R的功能形式包含SEQ ID No.86、87、88、89、90、91、92、93、94、95、96或97的序列。适当地，MGF 505 2R的功能形式包含与SEQ ID No.86、87、88、89、90、91、92、93、94、95、96或97具有至少70％、至少80％、至少90％或至少95％的同一性的序列。适当地，MGF 5052R的功能形式由SEQ ID No.86、87、88、89、90、91、92、93、94、95、96或97的序列组成。
MGF 505 3R基因序列
SEQ ID No.98–贝宁97/1MGF 505 3R
ATGTCCTCTTCCCTTCAGGAACTTTGTCGAAAAAAGCTGCCTGACTGCATACTTCCAGAGTTTTTTGACGACTATGTATTGCAACTGTTAGGACTGCACTGGCAAGATCATGGTTCCCTTCAGCGTATCGAGAAGAACCAGATACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTCAAAGTAGCAGCATCGGAAGGGAACTATGAAATCGTAGAGCTGTTGTTGTCATGGGAGGCAGATCCCCGCTACGCCGTCGTAGGAGCTCTAGAAAGCAAATACTATGACCTGGTTTACAAATACTATGACCTGGTTAAAGACTGCCATGATATCTTGCCGCTGATTCAAAATCCGGAAACATTTGAAAAATGTCATGAGTTAAACAACCCCTGTTCTCTTAAATGCTTATTCAAGCATGCTGTGATACATGACATGCTGCCGATTCTTCAAAAATATACATACTTTCTGGATGGGTGGGAGTATTGCAACCAGATGCTGTTCGAACTGGCATGTAGTAAAAAAAAATATGAGATGGTTGTGTGGATAGAGGGAGTTCTAGGCATCGGCAAAGTTACATCTCTTTTCACTATTGCGATTAGCAACAGAGACCTGCACCTGTATTCCCTGGGCCACTTAATCATTCTTGAGAGAATGCAGTCCTGTGGACAAGACCCCACGTTTTTACTAAATCATTTCCTGCGAGACGTTTCAATAAAAGGGCTTCTCCCTTTTGTACTGAAAACCATAGAATATGGTGGAAGCAAGGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAATACTTCGAAACCGGGAAATGCTAA
SEQ ID No.99–中国/2018/安徽XCGQ MGF 505 3R
ATGTCCTCTTCTCTTCAGGAACTTTGTCGAAAAAAGCTGCCTGACTGCATACTTCCAGAGTTTTTTGACGACTATGTATTGCAACTGTTAGGACTGCACTGGCAAGATCATGGTTCCCTTCAGCGTATCGAGAAGAACCAGATACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTCAAAGTAGCAGCATCGGAAGGGAACTATGAAATCGTAGAGCTGTTGTTGTCATGGGAGGCAGATCCCCGCTACGCCGTCGTAGGAGCCCTAGAAAGCAAATACTATGACCTGGTTTACAAATACTATGACCAAGTTAAAGACTGCCATGATATCTTGCCGCTGATTCAAAATCCGGAAACATTCGAAAGATGTCATGAGTTAAACAGCACCTGTTCACTGAAATGCTTATTCAAGCATGCTGTGATAAATGACATGCTGCCGATTCTTCAAAAATATACAGACTATCTGGATAGGTGGGAGTATTGCAGCCAGATGCTGTTCGAACTGGCATGTAGTAAAAAAAAATATGAGATGGTTGTGTGGATAGAGGGAGTTCTAGGCGTCGGCAAAGTTACATCTCTTTTCACCATTGCGATTAGCAACAGAGACCTACAGCTGTATTCTCTGGGCTACTCAATTATCCTTGAGAATTTGTACTCCTGTGGACAGGACCCCAAGTTTTTACTAAATCATTTCCTGCGAGACGTTTCAATAAAAGGGCTTCTACCCTTTGTAATCAAAACCATAGAATATGGTGGAAGCAAGGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAATACTTCGAAACCTGGGAAAGCTAG
SEQ ID No.100–格鲁吉亚2007/1MGF 505 3R
ATGTCCTCTTCTCTTCAGGAACTTTGTCGAAAAAAGCTGCCTGACTGCATACTTCCAGAGTTTTTTGACGACTATGTATTGCAACTGTTAGGACTGCACTGGCAAGATCATGGTTCCCTTCAGCGTATCGAGAAGAACCAGATACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTCAAAGTAGCAGCATCGGAAGGGAACTATGAAATCGTAGAGCTGTTGTTGTCATGGGAGGCAGATCCCCGCTACGCCGTCGTAGGAGCCCTAGAAAGCAAATACTATGACCTGGTTTACAAATACTATGACCAAGTTAAAGACTGCCATGATATCTTGCCGCTGATTCAAAATCCGGAAACATTCGAAAGATGTCATGAGTTAAACAGCACCTGTTCACTGAAATGCTTATTCAAGCATGCTGTGATAAATGACATGCTGCCGATTCTTCAAAAATATACAGACTATCTGGATAGGTGGGAGTATTGCAGCCAGATGCTGTTCGAACTGGCATGTAGTAAAAAAAAATATGAGATGGTTGTGTGGATAGAGGGAGTTCTAGGCGTCGGCAAAGTTACATCTCTTTTCACCATTGCGATTAGCAACAGAGACCTACAGCTGTATTCTCTGGGCTACTCAATTATCCTTGAGAATTTGTACTCCTGTGGACAGGACCCCAAGTTTTTACTAAATCATTTCCTGCGAGACGTTTCAATAAAAGGGCTTCTACCCTTTGTAATCAAAACCATAGAATATGGTGGAAGCAAGGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAATACTTCGAAACCTGGGAAAGCTAG
SEQ ID No.101–Ken05/Tk1 MGF 505 3R
ATGTCCTCTTCCCTTCAGGAACTTTGCCGAAAAAACTTACCCGACTACATACTTCCAGAGTTCTTTGACGACTATGTGTTGCAACTATTAGGACTACACTGGCAAGATCATGGTTCTCTTCAACGTACCGGAAAGAATCAGGTACTTGTTCAACAGGAACCCATTCATATCAATGAAGCACTAAAAGTGGCAGCATCAGAGGGAAACTTTGAAATCGTAGAACTGTTGTTGTCATGGAAGGCAGACCCCCGCTACGCTGTCGTAGGAGCGCTAGAAAGCAAATACTATGACCTCGTTTACAAGTATTACAACCTAGTTGAAGACCGCCATGATATGTTGCCGCTGATCCAAAATTCAGAAACGTTCGAAAGATGTCATGAGTTAAACAACTGTTCTCTTAAATGCTTATTCAAGCATGCTGTAATATATGACAAGCTGCCGATTCTACAAAAATATGCAGACTATTTGGACGGGTGGCCGTATTGCAACCAGATGCTGTTCGAGTTGGCATGTAAAAAACAAAAATATAACATGGTTGTGTGGATAGAGGGAGTCCTGGGCGTCGGCAACTTCACAATTCTTTTCACAATTGCGATTATCAAAAGGGACCTACAGCTGTATTCCCTGGGCTACTCCATCATCCTTGAGAGAATGTATTCCTGTGGATACGACCCCACGTTTTTACTAAATCACTATCTGCGAGTGGTTTCAACAAAAGGGCTTCTGCCTTTTGTACTGAAAACCATAGAATATGGTGGAAGCAAAGAGATAGCCTTAACTTTGGCTAAAAAATATCAGCATGAAACTATTTTGAGATACTTCGAAACCAGGAAATCCCAGGAGTGCTAA
SEQ ID No.102–Ken06.Bus MGF 505 3R
ATGTCCTCTTCCCTTCAGGAACTTTGCCGAAAAAACTTACCCGACCACATACTTCCAGAGTTCTTTGACGACTATATATTGCAACTATTAGGACTGCACTGGCAAGATCATGGTTCTCTTCAGCGTACCGAGAAGAATCAGGTACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTAAAAGTGGCAGCATCAGAAGGAAACTACGAAATAGTAGAGCTGTTGTTGTCATGGAAGGCAGACCCCCGATACGCTGTCGTAGGAGCGCTAGAAAGCAAATACTATGACCTCGTTTACAAATATTACGACCAAGTTAAAGACTGCCATGATATCTTGCCGCTGATCCAAAATTCGGAAACATTCGAAAGATGTCATGAGTTGAACAATTGTTCTCTTAAATGCTTATTCAAGCATGCTGTGATATATGACAAGCTGCCGATTCTTCAAAAATATGCAAGCTATCTGGATGGGTGGCCGTATTGCAACCAGATGCTGTTCGAGTTGGCATGTAAAAAACAAAAATATAACATGGCTGTATGGATAGAGGGAGTCCTGGGCGTCGGCAACTTCACAATTCTTTTCACGATTGCGATTATCAAAAGAGACCTACAGCTGTATTCCCTGGGCTACTCAATGATTCTTGAGAAAATGTACTCCTGTGGATACGACCCTACGTTTTTACTAAATCATTATCTGCGAATCGTTTCAACAAAGGGGCTTCTGCCCTTTGTGCTGAAAACCATAGAATATGGTGGAAGCAAAGAGATAGCCATCACTTTGGCTAAAAAGTATCAGCATGAAAATATTTTGAGATACTTCGAAACCAGGAAAACCCAAGAGTGCTAA
SEQ ID No.103–肯尼亚1950MGF 505 3R
ATGTCCTCTTCCCTTCAGGAACTTTGCCGAAAAAACTTACCCGACGACATACTTCCAGAGTTCTTTGACGACTATGTGTTGCAACTATTAGGACTACACTGGCAAGATCATGGTTCTCTTCAACGTACCGGAAAGAATCAGGTACTTGTTCAACAGGAACCCATTCATATTAATGAAGCACTAAAAGTGGCAGCATCAGAGGGAAACTTTGAAATCGTAGAACTGTTGTTGTCATGGAAGGCAGATCCCCGCTACGCTGTCGTAGGAGCGCTAGAAAGCAAATACTATGACCTCGTTTACAAGTATTACAACCTAATTGAAGACCGCCATGATATGTTGCCGCTGATCCAAAATTCAGAAACGTTCGAAAGATGTCATGAGTTAAACAACTGTTCTCTTAAATGCTTATTCAAGCATGCTGTGATATATGACAAGCTGCCGATTCTACAAAAATATGCAGACTATTTGGACGGGTGGCCGTATTGCAACCAGATGCTGTTCGAGTTGGCATGTAAAAAACAAAAATATAACATGGTTGTGTGGATAGAGGGAGTCCTGGGCGTCGGCAACTTCACAATTCTTTTCACGATTGCGATTATCAAAAGGGACCTACAGCTGTATTCCCTGGGCTACTCCATCATCCTTGAGAGAATGTACTCCTGTGGATACGACCCCACGTTTTTACTAAATCACTATCTGCGAGTGGTTTCAACAAAAGGGCTTCTGCCTTTTGTACTGAAAACCATAGAATATGGTGGAAGCAAAGAGATAGCCATCACTTTGGCTAAAAAGTATCAGCATGAAACTATTTTGAGATACTTCGAAACCAGGAAATCCCAGGAGTGCTAA
SEQ ID No.104–L60 MGF 505 3R
ATGTCCTCTTCCCTTCAGGAACTTTGTCGAAAAAAGCTGCCTGACTGCATACTTCCAGAGTTTTTTGACGACTATGTATTGCAACTGTTAGGACTGCACTGGCAAGATCATGGTTCCCTTCAGCGTATCGAGAAGAACCAGATACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTCAAAGTAGCAGCATCGGAAGGGAACTATGAAATCGTAGAGCTGTTGTTGTCATGGGAGGCAGATCCCCGCTACGCCGTCGTAGGAGCTCTAGAAAGCAAATACTATGACCTGGTTTACAAATACTATGACCTGGTTAAAGACTGCCATGATATCTTGCCGCTGATTCAAAATCCGGAAACATTTGAAAAATGTCATGAGTTAAACAACCCCTGTTCTCTTAAATGCTTATTCAAGCATGCTGTGATACATGACATGCTGCCGATTCTTCAAAAATATACATACTTTCTGGATGGGTGGGAGTATTGCAACCAGATGCTGTTCGAACTGGCATGTAGTAAAAAAAAATATGAGATGGTTGTGTGGATAGAGGGAGTTCTAGGCATCGGCAAAGTTACATCTCTTTTCACTATTGCGATTAGCAACAGAGACCTGCACCTGTATTCCCTGGGCCACTTAATCATTCTTGAGAGAATGCAGTCCTGTGGACAAGACCCCACGTTTTTACTAAATCATTTCCTGCGAGACGTTTCAATAAAAGGGCTTCTCCCTTTTGTACTGAAAACCATAGAATATGGTGGAAGCAAGGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAATACTTCGAAACCGGGAAATGCTAA
SEQ ID No.105–马拉维Lil-20/1/1983MGF 505 3R
ATGTCCCTTCAGGAACTTTGCCGAAAAAACCTGCCCGACTGCGAACTTCCAGAGTTCTTTGACGACTATGTATTGCAACTGTTAGGATTGCACTGGCAAGATCATGGTTCTCTTCAGCGTACCGGGAAGAATCAGGTACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTAAAAAGTGCGGCATCAGAAGGGAACTATGAAATCGTAGAGCTGCTGTTGTCATGGGAGGCAGATCCCCGCTACGCTGTCGTAGGAGCCCTAGAAAGCAATTACTATGACCTGGTTCACAAATATTATGACCAAGTTAAAGACTGCCATGATATGCTACCACTGATCCAAAATCCGGAAATGTTCGAAAAATGTCATGAGTTAAACAACACCTGTTCTCTTAAATGCTTATTCAAACATGCTGTGATACATGACATGCTGCCGATTCTTCAAAAATATTCAGACTATTTGGATGGGTGGCAGTATTGCAATCAGATACTGTTCGAATTGGCATGTAAAAGACAAAAATATAATATGGTTGTGTGGATAGAGGGAGTTCTAGGCGTCGGCAACTTTAAAATTCTTTTCACCATTGCCATTAACAACAGAGATCTACAGCTGTATTCTCTGGGGTACTTAATCATTCTTGAAAGATTGTACTCCTGTGGACAAGACCCCACGTTTTTACTAAACCATTTCCTACGAGACGTTTCAATGAAGGGGCTTCTGCCCTTTGTACTGAAAACCATAGAATTTGGTGGAAGTAAGGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAGTATTTCGAAACCGAAGAATGCTAA
SEQ ID No.106–Mkuzi 1979MGF 505 3R
ATGTCCTCTTCCCTTCAGGAACTTTGTCGAAAAAAGCTGCCTGACTGCATACTTCCAGAGTTTTTTGACGACTATGTATTGCAACTGTTAGGACTGCACTGGCAAGATCATGGTTCCCTTCAGCGTATCGAGAAGAACCAGATACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTCAAAGTAGCAGCATCGGAAGGGAACTATGAAATCGTAGAGCTGTTGTTGTCATGGGAGGCAGATCCCCGCTACGCCGTCGTAGGAGCTCTAGAAAGCAAATACTATGACCTGGTTTACAAATACTATGACCAAGTTAAAGACTGCCATGATATCTTGCCGCTGATTCAAAATCCGGAAACATTTGAAAAATGTCATGAGTTAAACAACCCCTGTTCTCTTAAATGCTTATTCAAGCATGCTGTGATACATGACATGCTGCCGATTCTTCAAAAATATACATACTTTCTGGATGGGTGGGAGTATTGCAGCCAGATGCTGTTCGAATTGGCATGTAGTAAAAAAAAATACGAGATGGTTGTGTGGATAGAGGGAGTTCTAGGCATCGGCAAAGTTACATCTCTTTTCACTATTGCGATTAGCAACAGAGACCTGCACCTGTATTCCCTGGGCCACTTAATCATTCTTGAGAGAATGCAGTCCTGTGGACAAGACCCCAAGTTTTTACTAAATCATTTCTTGCGAGACGTTTCAATAAAAGGGCTTCTCCCCTTTGTACTGAAAACCATAGAATATGGTGGAAGCAAGGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAATACTTCGAAACCGGGAAATGCTAA
SEQ ID No.107–NHV MGF 505 3R
ATGGTTGTGTGGATAGAGGGAGTTCTAGGCATCGGCAAAGTTACATCTCTTTTCACTATTGCGATTAGCAACAGAGACCTGCACCTGTATTCCCTGGGCCACTTAATCATTCTTGAGAGAATGCAGTCCTGTGGACAAGACCCCACGTTTTTACTAAATCATTTCCTGCGAGACGTTTCAATAAAAGGGCTTCTCCCTTTTGTACTGAAAACCATAGAATATGGTGGAAGCAAGGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAATACTTCGAAACCGGGAAATGCTAA
SEQ ID No.108–OURT 88/3MGF 505 3R
ATGGTTGTGTGGATAGAGGGAGTTCTAGGCATCGGCAAAGTTACATCTCTTTTCACTATTGCGATTAGCAACAGAGACCTGCACCTGTATTCCCTGGGCCACTTAATCATTCTTGAGAGAATGCAGTCCTGTGGACAAGACCCCACGTTTTTACTAAATCATTTCCTGCGAGACGTTTCAATAAAAGGGCTTCTCCCTTTTGTACTGAAAACCATAGAATATGGTGGAAGCAAGGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAATACTTCGAAACCGGGAAATGCTAA
SEQ ID No.109–Pretorisuskop/96/4MGF 505 3R
ATGTCTTCTTCCCTTCAGGAACTTTGTCGAAAAAAGCTGCCTGACTGCATACTTCCAGAGTTTTTTGACGACTATGTATTGCAACTGTTAGGACTGCACTGGCAAGATCATGGTTCTCTTCAGCGTATCGAGAAGAACCAGATACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTCAAAGTAGCAGCATCGGAAGGGAACTATGAAATCGTAGAGCTGTTGTTGTCATGGGAGGCAGATCCCCGCTACGCCGTCGTAGGAGCTCTCGAAAGCAAATACTATGACCTGGTTCACAAATACTATGGCCAAGTTAAAGACTGCCATGATATCTTGCCGCTGATTCAAAATCCGGAAACATTCGAAAAATGTCATGAGTTAAACAGCACCTGTTCACTGAAATGCTTATTCAAGCATGCTGTGATGAATGACATGCTGCCGATTCTTGAAAAATATACAGACTATCTGGATAGGTGGGAGTATTGCAGCCAGATGCTGTTCGAATTGGCATGCAGAAAAAAAAAATATGAGATGGTTGTGTGGATAGAGGGAGTTCTATGCGTCGGCAAAGTTACGTCTCTTTTCACCATTGCGATTAGCAACAGAGACCTACAGCTGTATTCTCTGGGCTACTCAATTATTCTTGAGAAAATGTACTCCTGTCGACAGGACCCCACGTTTTTACTAAATCATTTCCTGCGAGACGTTTCGATAAAGGGGCTTCTGCCCTTTGTACTGAAAACCATAGAATATGGTGGAAGCAAGGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAATACTTCGAAACCTGGGAAAGCTAG
SEQ ID No.110–Tengani 62MGF 505 3R
ATGTCCTCTTCCTCCCTTCAGGAACTTTGCCGAAAAAAGCTGCCTGACTGCATCCTTCCAGAGTTTTTCGACGACTATGTATTGCAACTGTTAGGACTGCACTGGCAAGATCATGGTTCTCTTCAGCGTATCGAGAAGAACCAGATACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTCAAAGTAGCAGCATCGGAAGGGAACTATGAAATCGTAGAGCTGTTGTTGTCATGGGAGGCAGATCCCCGCTACGCCGTCGTAGGAGCTCTCGAAAGCAAATACTATGACCTGGTTCACAAATACTATGACCAAGTTAAAGACTGCCATGATATCTTGCCGCTGATTCAAAATCCGGAAACATTCGAAAAGTGTCATGAGTTAAACAGCACCTGTTCACTGAAATGCTTATTCAAGCATGCTGTGATAAATGACATGCTGCCGATTCTTCAAAAATATACAGACTATCTGGATAGGTGGGAGTATTGTAGCCAGATGCTGTTCGAATTGGCATGTAGAAAAAAAAAGTATGAGATGGTTGTGTGGATAGAGGGAGCTCTGGGCGTCGGCAAAGTTACATCTCTTTTCACCATTGCGATTAGCAACAGAGACCTGCAGCTGTATTCTCTGGGCTACTCAATGATTCTTGAGAAATTGTACTCCTGTGGACAGGACCCCACGTTTTTACTAAATCATTTCCTGCGAGACGTTTCGATAAAGGGGCTTCTGCCCTTTGTACTCAAAACCATAGAATATGGTGGAAGCAAGGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAATACTTCGAAACTTGGGAAAGCTAG
SEQ ID No.111–Warmbaths MGF 505 3R
ATGTCCTCTTCCCTTCAGGAACTTTGTCGAAAAAAGCTGCCTGACTGCATACTTCCAGAGTTTTTCGACGACTATGTATTGCAACTGTTAGGACTGCACTGGCAAGATCATGGTTCTCTTCAGCGTATCGAGAAGAACCAGATACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTCAAAGTAGCAGCATCGGAAGGGAACTATGAAATCGTAGAGCTGTTGTTGTCATGGGAGGCAGATCCCCGCTACGCCGTCGTAGGAGCTCTCGAAAGCAAATACTATGACCTGGTTCACAAATACTATGGCCAAGTTAAAGACTGCCATGATATCTTGCCGCTGATTCAAAATCCGGAAACATTCGAAAAATGTCATGAGTTAAACAGCACCTGTTCACTGAAATGCTTATTCAAGCATGCTGTGATGAATGACATGCTGCCGATTCTTGAAAAATATACAGACTATCTGGATAGGTGGGAGTATTGCAGCCAGATGCTGTTCGAATTGGCATGTAGAAAAAAAAAATATGAGATGGTTGTGTGGATAGAGGGAGTTCTAGGCATCGGCAAAGTTACGCCTCTTTTCACCATTGCGATTAGCAACAGAGACCTACAGCTGTATTCTCTGGGCTACTCAATTATTCTTGAGAGAATGTATTCCTGTGAACAGGATCCCACGTTTTTACTAAATCATTTCCTGCGAGACGTTTCGATAAAGGGGCTTCTGCCCTTTGTACTGAAAACCATAGAATATGGTGGAAGCAAAGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAATACTTCGAAACATGGGAAAGCTAA
SEQ ID No.112–Warthog MGF 505 3R
ATGTCCTCTTCCCTTCAGGAACTTTGCCGAAAAAAGCTGCCTGACTGCATACTTCCAGAGTTTTTCGACGACTATGTATTGCAACTGTTAGGATTGCATTGGCAAGATCATGGTTCTCTTCAGCGTATCGAGAAGAACCAGATACTTGTTCAACAGGAACCCATCCATATCAATGAAGCACTCAAAGTAGCAGCATCGGAAGGGAACTATGAAATCGTAGAGCTGTTGTTGTCATGGGAGGCAGATCCCCGCTACGCCGTCGTAGGAGCTCTCGAAAGCAAATACTATGACCTGGTTCACAAATACTATGGCCAAGTTAAAGACTGCCATGATATCTTGCCGCTGATTCAAAATCCGGAAACATTTGAAAAGTGTCATGAGTTAAACAGCACCTGTTCACTGAAATGCTTATTCAAGCATGCTGTGATGAATGACATGCTGCCGATTCTTGAAAAATATACAGACTATCTGGATAGGTGGGAGTATTGCAGCCAGATGCTGTTCGAATTGGCATGTAGAAAAAAAAAATATGAGATGGTTGTGTGGATAGAGGGAGTTCTAGGCGTCGGCAAAGTTACGTCTCTTTTCACCATTGCGATTAGCAACAGAGACCTACAGCTGTATTCTCTGGGCTTCTCAATTATTCTTGAGAAATTGTACTCCTGTGGACAGGACCCCACGTTTTTACTAAATCATTTCCTGCGAGACGTTTCGATAAAGGGGCTTCTGCCCTTTGTACTCAAAACCATAGAATATGGTGGAAGCAAGGAGATAGCCATAACTCTGGCTAAAAAATATCAGCATAAACATATTTTGAAATACTTCGAAACCTGGGAAAGCTAG
在实施方案中，本发明的减毒ASFV包含MGF 505 3R的功能形式。适当地，MGF 5053R的功能形式包含SEQ ID No.98、99、100、101、102、103、104、105、106、107、108、109、110、111或112的序列。适当地，MGF 505 3R的功能形式包含与SEQ ID No.98、99、100、101、102、103、104、105、106、107、108、109、110、111或112具有至少70％、至少80％、至少90％或至少95％的同一性的序列。适当地，MGF 505 3R的功能形式由SEQ ID No.98、99、100、101、102、103、104、105、106、107、108、109、110、111或112的序列组成。在实施方案中，本发明提供了包含来自贝宁97/1毒株的以下序列的减毒ASFV：
(i)SEQ ID No.11(MGF 360 10L)和/或SEQ ID No.24(MGF 360 11L)，以及
(ii)SEQ ID No.86(MGF 505 2R)和/或SEQ ID No.98(MGF 505 3R)。
在实施方案中，本发明提供了包含来自中国/2018/安徽XCGQ毒株的以下序列的减毒ASFV：
(i)SEQ ID No.12(MGF 360 10L)和/或SEQ ID No.25(MGF 360 11L)，以及
(ii)SEQ ID No.87(MGF 505 2R)和/或SEQ ID No.99(MGF 505 3R)。
在实施方案中，本发明提供了包含来自格鲁吉亚2007/1毒株的以下序列的减毒ASFV：
(i)SEQ ID No.13(MGF 360 10L)和/或SEQ ID No.26(MGF 360 11L)，以及
(ii)SEQ ID No.88(MGF 505 2R)和/或SEQ ID No.100(MGF 505 3R)。
在实施方案中，本发明提供了包含来自Ken05/Tk1毒株的以下序列的减毒ASFV：
(i)SEQ ID No.14(MGF 360 10L)和/或SEQ ID No.27(MGF 360 11L)，以及
(ii)SEQ ID No.89(MGF 505 2R)和/或SEQ ID No.101(MGF 505 3R)。
在实施方案中，本发明提供了包含来自Ken06.Bus毒株的以下序列的减毒ASFV：
(i)SEQ ID No.15(MGF 360 10L)和/或SEQ ID No.28(MGF 360 11L)，以及
(ii)SEQ ID No.90(MGF 505 2R)和/或SEQ ID No.102(MGF 505 3R)。
在实施方案中，本发明提供了包含来自肯尼亚1950毒株的以下序列的减毒ASFV：
(i)SEQ ID No.16(MGF 360 10L)和/或SEQ ID No.29(MGF 360 11L)，以及
(ii)SEQ ID No.91(MGF 505 2R)和/或SEQ ID No.103(MGF 505 3R)。
在实施方案中，本发明提供了包含来自L60毒株的以下序列的减毒ASFV：
(i)SEQ ID No.17(MGF 360 10L)和/或SEQ ID No.30(MGF 360 11L)，以及
(ii)SEQ ID No.92(MGF 505 2R)和/或SEQ ID No.104(MGF 505 3R)。
在实施方案中，本发明提供了包含来自马拉维Li-20/1毒株的以下序列的减毒ASFV：
(i)SEQ ID No.18(MGF 360 10L)和/或SEQ ID No.31(MGF 360 11L)，以及
(ii)SEQ ID No.93(MGF 505 2R)和/或SEQ ID No.105(MGF 505 3R)。
在实施方案中，本发明提供了包含来自Mkuzi 1979毒株的以下序列的减毒ASFV：
(i)SEQ ID No.19(MGF 360 10L)和/或SEQ ID No.32(MGF 360 11L)，以及
(ii)SEQ ID No.94(MGF 505 2R)和/或SEQ ID No.106(MGF 505 3R)。
在实施方案中，本发明提供了包含来自Pretorisuskop/96/4毒株的以下序列的减毒ASFV：
(i)SEQ ID No.20(MGF 360 10L)和/或SEQ ID No.33(MGF 360 11L)，以及
(ii)SEQ ID No.95(MGF 505 2R)和/或SEQ ID No.109(MGF 505 3R)。
在实施方案中，本发明提供了包含来自Tengani 62毒株的以下序列的减毒ASFV：
(i)SEQ ID No.21(MGF 360 10L)和/或SEQ ID No.34(MGF 360 11L)，以及
(ii)SEQ ID No.96(MGF 505 2R)和/或SEQ ID No.110(MGF 505 3R)。
在实施方案中，本发明提供了包含来自Warmbaths毒株的以下序列的减毒ASFV：
(i)SEQ ID No.22(MGF 360 10L)和/或SEQ ID No.35(MGF 360 11L)，以及
(ii)SEQ ID No.97(MGF 505 2R)和/或SEQ ID No.111(MGF 505 3R)。
在实施方案中，本发明提供了包含来自Warthog毒株的以下序列的减毒ASFV：
(i)SEQ ID No.23(MGF 360 10L)和/或SEQ ID No.36(MGF 360 11L)，以及
(ii)SEQ ID No.112(MGF 505 3R)。
以下给出来自不同毒株的这些基因的翻译产物(即蛋白序列)：
SEQ ID No.1–格鲁吉亚2007/1MGF 360 10L蛋白
MFPSLQSFAKKVLARQQVSIEYHVILERCGLWWYKAPISLDCKHMLIKLPSFADGLDLNTALMLATKENNYQLIKLFTEWGADINYGLICANTPPVREFCWELGAKYRVDKKKIMHMFFKLIHPGTTSSNIILCLKLFNDNPFPAYVIIREIRSSIYWKLKRLVEDTDILSNMSDGDMLTIYCFIVALQDNLREAISYVYQHFKYLNTWWLICALCFNKLFDLHNLYEKEKIRMDVDEMMRMACTKDNNFLTIYYCFLLGANINSAMLACVRFYNMDNLFFCIDLGADAFEEAKALAEQRNYYLISHHLSLDIYSADSSLLTLKEADPNKIYHLLKNYKLKSMLA
SEQ ID No.2–格鲁吉亚2007/1MGF 360 11L蛋白
MLPSLQSLTKKVLAGQCIPVDQYHVLKCCGLWWHNGPIMLHIRRNKLFIRSTCFSQGIELNIGLMKAVKENNHDLIKLFTEWGADINYGMICALTENTRDLCKELGAKEYLEREYILKIFFDTTRDKTSSNIIFCHEVFSNNPNLRIIDNLDLRGEIMWELRGLMEITFMLDHDDSFSTVLTKYWYAIAVDYDLKDAIRYFYQKYPRLHRWRLMCALFYNNVFDLHELYEIERVRMDIDEMMHIACIQDYSYSAIYYCFIMGANINQAMLVSIQNYNLGNLFFCIDLGADAFEEGKALAEQKENYLIAHALSLKHYNPVISLLSIVTDPEKINCMLKNYHSINMGIFLDYEQR
SEQ ID No.7–格鲁吉亚2007/1MGF 505 2R蛋白
MFSLQDLCRKHLFILPDVFGEHVLQRLGLYWRCHGSLQRIGDDHILIRRDLILSTNEALRMAGEEGNNEVVKLLLLWKGNLHYAVIGALQGDQYDLIHKYENQIGDFHFILPLIQDANTFEKCHALERFCGVSCLLKHATKYNMLPILQKYQEELSMRAYLHETLFELACLWQRYDVLKWIEQTIHVYDLKIMFNIAISKRDLTMYSLGYIFLFDRGNTEATLLTQHLKKTAAKGLLHFVLETLKYGGNIDTVLTQAVKYNHRKLLDYFLRQLPRKHIEKLLLLAVQEKASKKTLNLLLSHLNYSVKRIKKLPRYVIEYESTLVIKILLKKRVNLIDAMLEKMVRYFSATKVRTIMDELSISPERVIKMAIQKMRTDIVIHTSYVWEDDLERLTRLKNMVYTIKYEHGKKMLIKVMHGIYKNLLYGEREKVMFYLAKLYVAQNAATQFRDICKDCYKLDVARFKPRFKQLILDCLEIITKKSCYSILEILEKHIISLFTMKVMTEEEKNLCLEILYKVIHYKTIQC
SEQ ID No.8–格鲁吉亚2007/1MGF 505 3R蛋白
MSSSLQELCRKKLPDCILPEFFDDYVLQLLGLHWQDHGSLQRIEKNQILVQQEPIHINEALKVAASEGNYEIVELLLSWEADPRYAVVGALESKYYDLVYKYYDQVKDCHDILPLIQNPETFERCHELNSTCSLKCLFKHAVINDMLPILQKYTDYLDRWEYCSQMLFELACSKKKYEMVVWIEGVLGVGKVTSLFTIAISNRDLQLYSLGYSIILENLYSCGQDPKFLLNHFLRDVSIKGLLPFVIKTIEYGGSKEIAITLAKKYQHKHILKYFETWES
MGF 360 12L蛋白序列
SEQ ID No.113–贝宁97/1MGF 360 12L蛋白
MLPSLQSLTKKVLAGQCVPTNQHYLLKYYDLWWYNAPITFDHNLRLIKSSGIKEGLDLNTALVKAVRENNYSLIKLFTEWGADINYGLVSVNTEHTRDLCQELGAKEILNEEEILQIFIDLKFHKTSSNIILCHEVFSNNPILQKVNNLKLRIEIFWELRELIEKTDLLNNEFLLSTLLLKYWYAIAVRYSLKEAIQYFYQKYTHMNTWRLTCALCFNNVFDLHEAYEKDKIHMDIEEMMRIACIKDHNLSTMYYCYMLGANINQAMLTSIQYYNIENMFFCMDLGADVFEEGTTALGEGYELIKNILSLKIYSPTTIPLPKSTDPEIIDHALKNYFSKNMMIFLSYDLR*
SEQ ID No.114–中国/2018/安徽XCGQ MGF 360 12L蛋白
MLPSLQSLTKKVLAGQCVPTNQHYLLKCYDLWWHDAPITFDHNLRLIKSAGIKEGLNLNTALVKAVRENNYNLIKLFAEWGADINYGLVSVNTEHTWDLCRELGAKETLNEEEILQIFIDLKFHKTSSNIILCHEVFSNNPILQKVNNIKMRIEIFWELRELIVKTDLLNNEFSLSTLLLKYWYAIAIRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKIHMDIEEMMRIACIKDHNLSTMYYCYVLGANINQAMLSSIQYYNIENMFFCIDLGADVFEEGTTALGEGYELIKNILSLKIYSPATTPLPKSTDPEIIDHALKNYVSKNMMIFLTYDLR*
SEQ ID No.3–格鲁吉亚2007/1MGF 360 12L蛋白
MLPSLQSLTKKVLAGQCVPTNQHYLLKCYDLWWHDAPITFDHNLRLIKSAGIKEGLNLNTALVKAVRENNYNLIKLFAEWGADINYGLVSVNTEHTWDLCRELGAKETLNEEEILQIFIDLKFHKTSSNIILCHEVFSNNPILQKVNNIKMRIEIFWELRELIVKTDLLNNEFSLSTLLLKYWYAIAIRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKIHMDIEEMMRIACIKDHNLSTMYYCYVLGANINQAMLSSIQYYNIENMFFCIDLGADVFEEGTTALGEGYELIKNILSLKIYSPATTPLPKSTDPEIIDHALKNYVSKNMMIFLTYDLR
SEQ ID No.115–Ken06.Bus MGF 360 12L蛋白
MLPSLQSLTKKVLARQCLPEDQHYLLKCYDLWWNNAPITFDHNLRLIKLAGIQEGLDLNMALVKAVKENNYSLIKLFTEWGANINYGLISVNTEHTWDLCRELGAKKTLNEGDILQIFIDLKFYKTSSNIILCHEVFSDNLLLKRVNNLKMRIEIFWELREIIEKTDLLNNEFSLNTLLLKYWYAIAVRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKICMDLEEMMRIACIKDHNLSTIYYCYMLGANINQAMLTSIQYYNIENIFFCMDLGADAFEEGMALVGQEGYEPIRNILSLKIYSPATTPLPKSTDPEIIDHALKNYFSKNMMVFLTYDLR*
SEQ ID No.116–肯尼亚1950MGF 360 12L蛋白
MLPSLQSLTKKVLAGQCLPEDQHYLLKCYDLWWNNAPITFDHNLRLIKSAGLQEGLDLNMALVKAVKENNYSLIKLFTEWGANINYGLISVNTEHTWDLCRELGAKKTLNEGDILQIFIDLKFHKTSSNIILCHEVFSDNLLLKKVNNLKMRIEIFWELREIIEKTDLLNNEFSLNTLLLKYWYAIAVRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKICMDLEEMMRIACIKDHSLSTIYYCYMLGANINQAMLTSIQYYNIENIFFCMDLGADAFEEGMALVGQEGYEPIRNILSLKIYSPATTPLPKSTDPEIIDHELKNYFSKNMMVFLTYDLR*
SEQ ID No.117–L60 MGF 360 12L蛋白
MLPSLQSLTKKVLAGQCVPTNQHYLLKYYDLWWYNAPITFDHNLRLIKSSGIKEGLDLNTALVKAVRENNYSLIKLFTEWGADINYGLVSVNTEHTRDLCQELGAKEILNEEEILQIFIDLKFHKTSSNIILCHEVFSNNPILQKVNNLKLRIEIFWELRELIEKTDLLNNEFLLSTLLLKYWYAIAVRYSLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKIHMDIEEMMRIACIKDHNLSTMYYCYMLGANINQAMLTSIQYYNIENMFFCMDLGADVFEEGTTALGEGYELIKNILSLKIYSPTTIPLPKSTDPEIIDHALKNYFSKNMMIFLSYDLR*
SEQ ID No.118–马拉维Lil-20/1MGF 360 12L蛋白
MLPSLQSLTKKVLAGQCLPTDQYYLLKCYDLWWYDSPITFDHNLGLIKSAGIKDGLDLNTALVKAVRENNYNLIKLFTEWGADINYGLVSVNTEHTRDLCRELGAKETLNEEEILRIFIDLKFYKTSSNIILCHEVFSNNPLLQKVNNLKMRIEIFWELRELIKKTDLLNNEFSLNTLLLKYWYAIAVRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKIYMDLEEMMRVACIKDHNLSTIYYCYVLGANINQAMLASIQYYNIENMFFCMDLGADVFEENMPVGEGYELIRNILSLKIYSPSTAPLPKNTDPEIIDHVLKNYKSKNMMTFLSYDLR*
SEQ ID No.119–Mkuzi 1979MGF 360 12L蛋白
MLPSLQSLTKKVLAGQCVPTNQHYLLKYYDLWWHDAPITFDHNLRLIKSAGIKEGLDLNTALVKAVKENNYNLIKLFAEWGADINYGLVSVSSEHTWDLCRELGAKETLNEKEILQIFIDLKFHKTSSNIILCHEVFSNNPILQKVNNIKMRIEIFWELRELIEKTDLLNNEFSLSTLLLKYWYAIAIRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKIYMDIEEMMRIACIKDHNLSTMYYCYMLGANINQAMLTSIQYYNIENMFFCMDLGADVFEEGTTALGEGYELIKNILSLKIYSPTTIPLPKSTDPEIIDHALKNYFSKNMMIFLSYDLR*
SEQ ID No.120–Pretorisuskop/96/4MGF 360 12L蛋白
MLPSLQSLTKKVLAGQCVPTNQHYLLKCYDLWWHDGPITFDHNLKLIKSAGIKEGLDLNTALVKAVRENNYNLIKLFAEWGANINYGLVSVNTEHTWDLCRELGAKETLNEEEILQIFIDLKFHKTSSNIILCHEVFSNNPILQKVNNIKMRIEIFWELRELIEKTDLLNNEFSLSTLLLKYWYAIAIRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKIHMDIEEMMRIACIKDHNLSTMYYCYVLGGNINQAMLTSIQYYNIENMFFCMDLGADAFEEGTIALGEGYKLIKNILSLKIYSPATTPLPKSTDPEIIDHALKNYVSKNMMIFLTYDLR*
SEQ ID No.121–Tengani 62MGF 360 12L蛋白
MLPSLQSLTKKVLAGQCVPTNQHYLLKCYDLWWHDAPITFDHNLRLIKSAGIKEGLNLNTALVKAVRENNYNLIKLFAEWGADINYGLVSVNTEHTWDLCRELGAKETLNEEEILQIFIDLKFHKTSSNIILCHEVFSNNPILQKVNNIKMRIEIFWELRELIEKTDLLNNEFSLSTLLLKYWYAIAIRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKIHMDIEEMMRIACIKDHNLSTMYYCYVLGANINQAMLSSIQYYNIENMFFCIDLGADVFEEGTTALGEGYELIKNILSLKIYSPATTPLPKSMDPEIIDHALKNYVSKNMMIFLTYDLR*
SEQ ID No.122–Warmbaths MGF 360 12L蛋白
MLPSLQSLTKKVLAGQCVPTNQHYLLKCYDLWWHDGPITFDHNLKLIKSAGIKEGLDLNTALVKAVRENNYNLIKLFAEWGADINYGLVSVNTEHTRDLCRELGAKETLNEEEILQIFIDLKFHKTSSNIILCHEVFSNNPILQKVNNIKMRIEIFWELRELIEKTDLLNNEFSLSTLLLKYWYAIAIRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKIYMDIEEMMRIACIKDHNLSTMYYCYVLGANINQAMLTSIQYYNVENMFFCMDLGADAFEEGTIALGEGYKLIKNILSLKIYSPATTPLPKSTDPEIIDHAVKNYVSKNMMIFLTYDLR*
SEQ ID No.123–Warthog MGF 360 12L蛋白
MLPSLQSLTKKVLAGQCVPTNQHYLLKCYDLWWHDGPITFDHNLKLIKSAGIKEGLDLNTALVKAVRENNYNLIKLFAEWGANINYGLVSVNTEHTRDLCRELGAKETLNEEEILQIFIDLKFHKTSSNIILCHEVFSNNPILQKVNNIKMRIEIFWELRELIEKTDLLNNEFSLSALLLKYWYAIAIRYNLKEAIQYFYQKYTHLNTWRLTCALCFNNVFDLHEAYEKDKIHMDIEEMMRIACIKDHNLSTMYYCYVLGANINQAMLTSIQYYNIENMFFCMDLGADAFEEGTIALGEGYKLIKNILSLKIYSPATTPLPKSTDPEIIDHALKNYVSKNMMIFLTYDLR*
MGF 360 13L蛋白序列
SEQ ID No.124–贝宁97/1MGF 360 13L蛋白
MSLPLSLQTLVKKTVASQCLSIDEHCILKYCGLWWHDAPLKLCMDRGRIQIKSGFLGEDIDLRVALIIAVKENNYSLIKLFTEWGANINYSLLSINTKHIRELCRQLGAKETLEDNDIFRIFTRIMHNKTSGSIILCHEIFMNNPMLENKFVIQLRGLIYKRLWGLIEIKETDELNDLLVKYWYAKAVQYVCKNAICFLDEKYTDLNEWRLKCLLYYNKIYELHEMYHKKKVQIDVHDMICLACAKDNNLLTIYYCYALGGNINQAMLTSVQYYNVGNIFFCIDLGGNAFEEGRAIAEQKGYNFLSHSLTLDIYSSDASLPLNLKDPEKISSLLKDYKSKNLSIIWEYSHNIL*
SEQ ID No.125–中国/2018/安徽XCGQ MGF 360 13L蛋白
MSLPLSLQTLVKKTIASQCLSIDEHCILKYCGLWWHDAPLKLCMDRGRIQIKSGFLGEDIDLRVALIIAVKENNYSLIKLFTEWGANINYGLLSINTKHIRELCRQLGAKETLEDNDIFRIFTRIMHNKTSGSIILCHEIFMNNPILENKFVIQLRGLIYKRLWGLIEIKETDELNGLLVKYWYAKAVQYDCKDAICFLDEKYTDLNEWRLKCLLYYNKIYELHEMYHKENIQIDVHDMICLASTKDNNPLTIYYCYALGGNINQAMLTSVQYYNIGNIFFCIDLGGNAFEEGRAIAEQKGYNFLSHSLALDIYSSDASLPLNLKDPEEISSLLKDYKSKNLSIIWEYSHNIL*
SEQ ID No.4–格鲁吉亚2007/1MGF 360 13L蛋白
MSLPLSLQTLVKKTIASQCLSIDEHCILKYCGLWWHDAPLKLCMDRGRIQIKSGFLGEDIDLRVALIIAVKENNYSLIKLFTEWGANINYGLLSINTKHIRELCRQLGAKETLEDNDIFRIFTRIMHNKTSGSIILCHEIFMNNPILENKFVIQLRGLIYKRLWGLIEIKETDELNGLLVKYWYAKAVQYDCKDAICFLDEKYTDLNEWRLKCLLYYNKIYELHEMYHKENIQIDVHDMICLASTKDNNPLTIYYCYALGGNINQAMLTSVQYYNIGNIFFCIDLGGNAFEEGRAIAEQKGYNFLSHSLALDIYSSDASLPLNLKDPEEISSLLKDYKSKNLSIIWEYSH
NIL
SEQ ID No.126–Ken06.Bus MGF 360 13L蛋白
MSSPLSLQTLVKKTVAGTSCLSIDEHILKYCGLWWHDAPLKLYIDRGRIYIKSGFLGEDIDLCVALIIAVKENNYS
MIKLFTEWGAYINYSLLSINTKHARDLCRQLGAKETLDDYDIFCIFNKIMHNKTSGSIILCHEIFINNPNLENNFAAQLRRLIYKRLCGLIEIKETDELSELLVKYWYANAVQYDHKDAICFLDEKYTDLDEW*LKCYLCYNKIYELHDIYHKEKIQIDVNEMLSLACIRDNNLLTIYYCYALGGNINQAMLTSVQYYNIGNIYFCIDLGGNAFEEGSAIARQNGYNFLSHSLVLNIYSSDASLPLNLKDPEEISSLLKNYKSKNLSIILDYSHKIL*
SEQ ID No.127–肯尼亚1950MGF 360 13L蛋白
MSSPLSLQTLVKKTVASTSCLSIDEHILKYCGLWWHDAPLKLYIDRGRIYIKSGFLGEDIDLCVALIIAVKENNYSLIKLFTEWGAYINYSLLSINTKHARDLCRQLGAKETLDDYDIFCIFNKIMHNKTSGSIILCHEIFINNPKLENNFAAQLRRLIYKRLCGLIEIKETDELSELLVKYWYANAVQYDHKDAICFLDEKYTDLDEWRLKCYLCYNKIYELHDIYHKKKIQIDVNEMLSLACIRDNNLLTIYYCYALGGNINQAMLTSVQYYNIGNIYFCIDLGGNAFEEGSAIARQNGYNFLCHSLILNIYSSDASLPLNLKVPEEISSLLKNYKSKNLSIILDYSHKIL*
SEQ ID No.128–L60 MGF 360 13L蛋白
MSLPLSLQTLVKKTVASQCLSIDEHCILKYCGLWWHDAPLKLCMDRGRIQIKSGFLGEDIDLRVALIIAVKENNYSLIKLFTEWGANINYSLLSINTKHIRELCRQLGAKETLEDNDIFRIFTRIMHNKTSGSIILCHEIFMNNPMLENKFVIQLRGLIYKRLWGLIEIKETDELNDLLVKYWYAKAVQYVCKNAICFLDEKYTDLNEWRLKCLLYYNKIYELHEMYHKKKVQIDVHDMICLACAKDNNLLTIYYCYALGGNINQAMLTSVQYYNVGNIFFCIDLGGNAFEEGRAIAEQKGYNFLSHSLTLDIYSSDASLPLNLKDPEKISSLLKDYKSKNLSIIWEYSHNIL*
SEQ ID No.129–马拉维Lil-20/1(1983)MGF 360 13L蛋白
MSAPLSLQTLVKKTVASTSCLSIDEHILKYCDLWWHDAPLKLYMDRGRIQIKSGFLGEDIDLCVALIIAVKENNYNLIKLFTELGANINYSLLSINTKHVRDLCRQLGAKETLEDYDIFCIFNKIMHNKTSGSVILCHEIFINNPNLENKFAAQLRRLIYKRLCGLIEIKETDELSELLVKYWYAKAVQYDYKDAICFLDEKYTDLNEWRLKCYLYYNKIYELHDIYHKEKIQIDVNEMLSLACIRDNNPLTIYYCYALGGNINQAMLTSVQYYNIGNIYFCIDLGGNAFEEGSAIARQKGYNFLSHSLVLNIYSSDASLPLNLKDPEEISSLLKNYKSKNLSIILDYSHNIL*
SEQ ID No.130–Mkuzi 1979MGF 360 13L蛋白
MSLPLSLQTLVKKTVASQCLSIDEHCILKYCGLWWHDAPLKLCMDRGRIQIKSGFLGEDIDLRVALIIAVKENNYSLIKLFTEWGANINYSLLSINTKHIRELCRQLGAKETLEDNDIFRIFTRIMHNKTSGSIILCHEIFMNNPILENKFVIQLRGLIYKRLWGLIEIKETDKLNDLLVKYWYAKAVQYVCKNAICFLDEKYTDLNEWRLKCLLYYNKIYELHEMYHKKKVQIDVHDMICLACAKDNNLLTIYYCYALGSNINQAMLTSVQYYNIGNIFFCIDLGGNAFEEGRAIAEQKGYNFLSHSLTLDIYSSDASLPLNLKDPEEISSLLKDYKSKNLSIIWEYSHNIL*
SEQ ID No.131–Pretorisuskop/96/4MGF 360 13L蛋白
MSLPLSLQTLVKKTVASQCLSIDEHCILKHCGLWWHDVPLKLCMDRGQIQIKSGFLGEDIDLHIALIIAVKENNYSLIKLFTEWGAHINYSLLSINTEHIRELCRQLGAKETLEDDDVFRIFTKIMHNKTSGRIILCHDIFMNNPNIENKFTIQLRGLICKRLWGLIEIKETDELNDLLVKYWYAKAVQYECKDAICFLEEKYTDLNEWRLKCLLYFNKIYELHEMYHKEKVQIDVHDMICLASTKDNNPLTIYYCYALGGNINQAMLTSIQYYNIGNIFFCIDLGGNAFEEGRAIAEQKGYNFLSHSLALDIFSSDASLPLNLKDPEEISSFLKDYKSKNLSIIWEYSHNIL*
SEQ ID No.132–Tengani 62MGF 360 13L蛋白
MSLPLSLQTLVKKTVANQSLSIDEHCILKHCGLWWHDVPLKLCMDRGQIQIKSGFLGEDIDLHIALIIAVKENNYSLIKLFTEWGANINYSLLSINTKHIRELCRQLGAKETLEDDDIFRIFTKIMHNKTSGSIILCHDIFMNNPNIEDKFTIQLRGLIYKRLWGLIEIKETDELNGLLVKYWYAKAVQYECKDAICFLDEKYTDLNEWRLKCLLYYNKIYELHEMYHKENIQIDVHDMICLASTKDNNPLTIYYCYALGGNINQAMLTSVQYYNIGNIFFCIDLGGNAFEEGRAIAEQKGYNFLSHSLALDIYSSDASLPLNLKDPEEISSLLKDYKSKNLSIIWEYSHNIL*
SEQ ID No.133–Warmbaths MGF 360 13L蛋白
MSLPLSLQTLVKKTVASQCLSTDEHCILKHCGLWWHDVPLKLCMDRGQIQIKSGFLGEDIDLHVALIIAVKENNYSLIKLFTEWGAHINYSLLSINTEHIRELCRQLGAKKTLEDNDIFRIFTKIMHNKTSGRIILCHEIFMNNPNIENKFTIQLRGLICKRLWRLIEIKETDELNDLLVKYWYAKAVQYECKDAICFLDEKYTGLNEWRLKCLLYYNKIYELHEMYHKDKVQIDVHDMICLASTKDNNPLTIYYCYALGGNINQAMLTSVQYYNIGNIFFCIDLGGNAFEEGRAIAEQKGYHFLSHSLALDIYSSDASLPLNLKDPEEISSLLKGYKSKNLSIIWEYSHNIL*
SEQ ID No.134–Warthog MGF 360 13L蛋白
MSLPLSLQTLVKKTVASQCLSTDEHCILKHCGLWWHDVPLKLCMDRGQIQIKSGFLGEDIDLHIALIIAVKENNYSLIKLFTEWGAHINYSLLSINTEHIRELCRQLGAKETLEDNDIFRIFTKIMHNKTSGRIILCHEIFMNNPNIENKFTIQLRGLICKRLWGLIEIKETDELNDLLVKYWYAKAVQYECKDAICFLDEKYTDLNEWRLKCLLYYNKIYELHEMYHKEKVQIDVHDMICLASTKDNNPLTIYYCYALGGNINQAMLTSVQYYNIGNIFFCIDLGGNAFEEGRAIAEQKGYHFLSHSLTLDIYSSDASLPLNLKDPEEISSLLKDYKSKNLSIIWEYSHNIL*
MGF 360 14L蛋白序列
SEQ ID No.135–贝宁97/1MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYTLQRFGLWWDLGPIHLCNNCKQVFSYKHLQCFSEDDLCLEAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVYLKRLCAELGGLTPVSEPRLLEILKEVANLKSCAGVLLGYDMFCHNPLLETVTRTTLDTVTYTCSNIPLTGDTAHLLLTKFWFALALRHNFTKAIHYFYKRHKNQLYWRVACSLYFNNIFDIHELCREKEICISPNLMMKFACLREKNYAAIYYCHRLGASLDYGMNLSIYNNNTLNMFFCIDLGAADFDRAQLIAHKAYMYNLSNIFLVKQLFSRDVTLVLDVTEPQEIYDMLKTYTSKNMKRAEEYLTAHPEIIVID*
SEQ ID No.136–中国/2018/安徽XCGQ MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYTLQRFGLWWDLGPIHLCNNCKQVFSYKHLQCFSEDDLCLEAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVYLKRLCAELGGLTPVSEPRLLEILKEVARLKSCAGVLLGYDMFCHNPLLETVTRTTLDTVTYTCSNIPLTGDTAHHLLTKFWFALALRHNFTKAIHYFYKRHKNHLYWRVACSLYFNNIFDIHELCREKEICISPNLMMKFACLREKNYAAIYYCHRLGASLDYGMNLSIYNNNTLNMFFCIDLGAADFDRAQLIAHKAYMYNLSNIFLVKQLFSRDVTLVLDVTEPQEIYDMLKTYTSKNLKRAEEYLTAHPEIIVID*
SEQ ID No.5–格鲁吉亚2007/1MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYTLQRFGLWWDLGPIHLCNNCKQVFSYKHLQCFSEDDLCLEAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVYLKRLCAELGGLTPVSEPRLLEILKEVARLKSCAGVLLGYDMFCHNPLLETVTRTTLDTVTYTCSNIPLTGDTAHHLLTKFWFALALRHNFTKAIHYFYKRHKNHLYWRVACSLYFNNIFDIHELCREKEICISPNLMMKFACLREKNYAAIYYCHRLGASLDYGMNLSIYNNNTLNMFFCIDLGAADFDRAQLIAHKAYMYNLSNIFLVKQLFSRDVTLVLDVTEPQEIYDMLKTYTSKNLKRAEEYLTAHPEIIVID
SEQ ID No.137–Ken06.Bus MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYTLQRFGLWWDLGPIHLCNTCKQIFSYQHLQCFSVDDLCLDAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVHLKRLCTELGGLTPVSESRLLEILKEVADLKSCAGVLLGYDMFCHNPLMETVTRTTLNTVMYTRSKIPLTGDTAHLLLTKFWFALALRHNFTKAIHYFYEKHKNQLYWRLTCSLYFNNIFDLHELCSKKEICISPNLMMKFACLREENYAAIYYCHMLGASPDYGMNLSIYNNNTLNLFFCIDLGATNFDRARLIAHRVYMYNLSNIFLVKQLFSRDASLVLNITEPQAIYDMLKTYTSKNLKRAEEYFTAHPEIVVID*
SEQ ID No.138–肯尼亚1950MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYTLQRFGLWWDLGPIHLCNTCKQIFSYQHLQCFSEDDLCLDAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVDLKRLCTELGGLTPVSESRLLEILKEVADLKSCAGVLLGYDMFCHNPLLETVTRTTLNTVMYTRSKIPLTGDTAHLLLTKFWFALALRHNFTKAIHYFYEKHKNQLYWRLACSLYFNNIFDLHELCSKKEICISPNLMMKFACLREENYAAIYYCHMLGASPDYGMNLSIYNNNTLNLFFCIDLGATNFDRARLIAHRVYMYNLSNIFLVKQLFSRDASLVLNITEPQAIYDMLKTYTSKNLKRAEEYFTAHPEIVVID*
SEQ ID No.139–L60 MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYTLQRFGLWWDLGPIHLCNNCKQVFSYKHLQCFSEDDLCLEAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVYLKRLCAELGGLTPVSEPRLLEILKEVANLKSCAGVLLGYDMFCHNPLLETVTRTTLDTVTYTCSNIPLTGDTAHLLLTKFWFALALRHNFTKAIHYFYKRHKNQLYWRVACSLYFNNIFDIHELCREKEICISPNLMMKFACLREKNYAAIYYCHRLGASLDYGMNLSIYNNNTLNMFFCIDLGAADFDRAQLIAHKAYMYNLSNIFLVKQLFSRDVTLVLDVTEPQEIYDMLKTYTSKNMKRAEEYLTAHPEIIVID*
SEQ ID No.140–马拉维Lil-20/1MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYTLQRFGLWWDLGPIHLCNTCKQIFSYKHLQCFSEDDLCLEAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVHLKRLCMELGGLTPVSESRLLEILKEVADLKSCAGVLLGYDMFCHNPLLETVTRTTLDTVMYTRSKIPLTGDTAHLLLSKFWFALALRHNFTKAIHYFYEKHKNQLYWRLTCSLYFNNIFDLHELCCKKEICISPNLMMKFACLREENYAAIYYCHMLGASLDYGMNLSIYNNNTLNLFFCIDLGATNFDRARLIARRVYMYNLSNLFLVKQLFSRDVSLILDLTEPQAIYDMLNTYTSKNLKQAEEYFTAHPEIVVID*
SEQ ID No.141–Mkuzi 1979MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYTLQRFGLWWDLGPIHLCNNCKQVFSYKHLQCFSEDDLCLEAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVYLKRLCAELGGLTPVSEPRLLEILKEVANLKSCAGVLLGYDMFCHNPLLETVTRTTLDTVTYTCSNIPLTGDTAHLLLTKFWFALALRHNFTKAIHYFYKRHKNQLYWRVACSLYFNNIFDIHELCREKEICISPNLMMKFACLREKNYAAIYYCHRLGASLDYGMNLSIYNNNTLNMFFCIDLGAADFDRAQLIAHKAYMYNLSNIFLVKQLFSRDVTLVLDVTEPQEIYDMLKTYTSKNMKRAEEYLTAHPEIIVID*
SEQ ID No.142–Pretorisuskop/96/4MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYTLQRFGLWWDLGPIHLCNNCKQIFSYKHLQCFSEDDLCLEAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVHLKRLCTELGGLTPVTEPRLLEILKEVAKLKSCAGVLLGYDMFCHNPLLETVTRTTLDTVTYTCSNIPLTGDTAHLLLTKFWFALALRHNFTKAIHYFYKRHKNHLYWRVACSLYFNNIFDIHELCREKEICISPNLMMKFACLQKKNYAAIYYCYRLGASLDYGMNLSIYNNNTLNMFFCIDLGATDFDRAQHIAHKAYMYNLSNIFLVKQLFSRDVTLALDVTEPQEIYDRLKSYTSKNLKRAEEYLTAHPEIIVID*
SEQ ID No.143–Tengani 62MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYTLQRFGLWWDLGPIHLCNNCKQIFSYKHVQCFSEDDLCLEAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVHLKRLCTELGGLTPVSESRLLEILKEVARLKSCAGVLLGYDMFCHNPLLETVTRTTLDTVTYTCSNIPLTGDTAHHLLTKFWFALALRHNFTKAIHYFYKRHKNHLYWRVACSLYFNNIFDIHELCREKEICISPNLMMKFACLQKKNYAAIYYCYRLGASLDYGMNLSIYNNNTLNMFFCIDLGATDFDRAQRIAHKAYMYNLSNIFLVKQLFSRDVTLALDVTEPQEIYDMLKSYTSKNLKRAEEYLTAHPEIIVID*
SEQ ID No.144–Warmbaths MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYMLQRFGLWWDLGPIHLCNNCKQIFSYKHLQCFSEDDLCLEAALVKAVKRDNLELIRLFVDWGANPEYGLICVPTVHLKRLCTELGGLTPVSEPRLLEILKEVANLKSCAGVLLGYDMFCYNPLLETITRTTLDTVMYSCSKIPLMGDTAHHLLTKFWFALALRHNFTKAIHYFYKRHKNHLYWRVACSLYFNNIFDIHELCREKEICISPNLMMKFACLREKNYAAIYYCYRLGASLDYGMNLSIYNNNSLNLFFCIDLGATDFDRAQRIAHKAYMYNLSNILLVKQLFSRDVTLALDVTEPQEIYDRLKAYTSKNMKRAEEYLTAHPEIIVID*
SEQ ID No.145–Warthog MGF 360 14L蛋白
MLSLQTLAKKVVACNYLSSDYDYMLQRFGLWWDLGPIHLCNNCKQIFSYKHLQCFSEDDLCLEAALVKAVKSDNLELIRLFVDWGANPEYGLIRVPAVHLKRLCTELGGLTPVSEPRLLEILKEVAKLKSCAGVLLGYDMFCHNPLLETVTRTTLDTVTYTCSNIPLTGDTAHHLLTKFWFALALRHNFTKAIHYFYKRHKNHLYWRVACSLYFNNIFDIHELCREKEICISPNLMMKFACLRKKNYAAIYYCYRLGASLDYGMNLSIYNNNTLNMFFCIDLGATDFDRAQRIAHKTYMYNLSNIFLVKQLFSRDVTLALDVTEPQEIYDMLKSYTSKNLKRAEEYLTAHPEIIVID*
MGF 505 1R蛋白序列
SEQ ID No.146–贝宁97/1MGF 505 1R蛋白
MFSLQNLCRKTLPDCKLPEFFDDYILQLLGLYWENHGTIQRAGNNCVLIQQHTLIPVNEALRIAASEENYEIVGLLLAWEGNLYYAIIGALEGNRYNLIRKYDDQIKDHHDILPFIDDPIIFHKCHIMRRCFFDCILYQAVKYSKFRVLLYFKYTLEDDLPLVHLLIEKACEDHNYEVIKWIYENLHVCHIIDTFDCAIAHKDLRLYCLGYTFIYNRIVPYKYHHLDILILSSLQLLHKVAAKGYLDFILETLKYDHNIDNLDVILTQAATYNHRKILTYFIPQSTYAQIEQCLFVAIKTKSSKKTLNLLLSHLNLSIKLIQKISQYVATFNSTNIIGILSMKRKKKIYLDIILTKFVKNAIFNKFVVRCMERFSINPERIVKMAARINKMMLVKKISEHVWKNHAARLKHLKHAVHTMKHKDGKNRLMNFIYEHCYYHMQGEEIFSLARFYAIHHAPKLFDVFYNCCILDTIRFKSLLLDCSHIIGKNAHDATNINIVNKYIGNLFAMGVLSKKEILQDYPSIYSKHYMP*
SEQ ID No.147–中国/2018/安徽XCGQ MGF 505 1R蛋白
MFSLQNLCRKTLPNRKLPEFFDEYILQLLGLYWENHGTIQRAGNNCVLIQQHTLIPVNEALRTAASEENYEIVSLLLAWEGNLYYAIIGALEGNRHDLIRKYDDQIKDHHEILPFIDDPVIFHKCHIMRQCFFDCILYQAVKYSKFRVLLYFKHRLEDDLPFTHLLIEKACKDHNYEVIKWIYENLHIYNMIDTFECAIAHKDLHLYCLGYRFIYNRIVPDKYHHLDIRMLSSLQLLHKVAAKGYLDFILETLKYDHNKDNINIILTQAATYNHRKILIYFIPQSTHAQIEQCLLVAIKAKSSRKTLNLLLSHLNLSINLIKKISHYVATYNSTNIIGILSMRRKKKIYLDIILTKFVKKAIFNKFVVRCMDTFSINPERILKIAARINRMMLVKKISEHVWKNHAVRLKYLKHAVHTMKHKDGKNRLMNFIYDRCYYHMQGEEIFSLARFYAIHHAPKLFDVFYDCCILDTIRFKSLLLDCSHIIGKNAHDATNINIVNKYIGNLFVMGVLSKKEILQDYPSIYSKQYMP*
SEQ ID No.6–格鲁吉亚2007/1MGF 505 1R蛋白
MFSLQNLCRKTLPNRKLPEFFDEYILQLLGLYWENHGTIQRAGNNCVLIQQHTLIPVNEALRTAASEENYEIVSLLLAWEGNLYYAIIGALEGNRHDLIRKYDDQIKDHHEILPFIDDPVIFHKCHIMRQCFFDCILYQAVKYSKFRVLLYFKHRLEDDLPFTHLLIEKACKDHNYEVIKWIYENLHIYNMIDTFECAIAHKDLHLYCLGYRFIYNRIVPDKYHHLDIRMLSSLQLLHKVAAKGYLDFILETLKYDHNKDNINIILTQAATYNHRKILIYFIPQSTHAQIEQCLLVAIKAKSSRKTLNLLLSHLNLSINLIKKISHYVATYNSTNIIGILSMRRKKKIYLDIILTKFVKKAIFNKFVVRCMDTFSINPERILKIAARINRMMLVKKISEHVWKNHAVRLKYLKHAVHTMKHKDGKNRLMNFIYDRCYYHMQGEEIFSLARFYAIHHAPKLFDVFYDCCILDTIRFKSLLLDCSHIIGKNAHDATNINIVNKYIGNLFVMGVLSKKEILQDYPSIYSKQYMP
SEQ ID No.148–Ken05/Tk1 MGF 505 1R蛋白
MFSLQNLCRKTLPDCKLPEFFDDYVLQLLGLYWENHGTIQRAGNNCVLIQQHNLIPVNEALRIAASEENYEIVSLLLAWEGNLYYAIIGALEGNRHNLIRKYDDQIKDHHEILPFIDDPVIFHKCHIMRRCFFNCMLYQAVKYSKFSVLLYFKYILKENLPLVHSLIEKAYKYHNYEVIKWIYENLHIYDIINTFKYAIAHKDLRLYCLGYTFVYNRIVPYKYYHLDIRILLRLQLLHKVTAKGYLDFILETLKYDHNTNNIDIILTQAATYNHRNILTYFIPQSTYAQIEQCLFVAIKTNASKKTLNLLLSHLNLSIKLVKKLSQYVVAYKSTNIISILSMQQKKKIYLDIILTKVVKNAVFIKFVIGCMVTFSINPERIVKMAARIKKMKLVKNISEHVWKNHAAKLKHLKHAVHTMKHQEGKNRLMNFIYDHCYYHMQGEEIFSLARFYAIHHAPKLFDVFYDCCILDTIRFKSLLLDCSHIIAKNAHDASINIVNKYIGNLFAMGVLSKKEILQDYPSIYSKYDIL*
SEQ ID No.149–Ken06.Bus MGF 505 1R蛋白
MFSLQNLCRKTLPDCKLPEFFDDYVLQLLGLYWENHGTIQRAGNNCVLIQQHNLIPVNEALRIAASEENYEIVSLLLAWEGNLYYAIIGALEGNHHNLIRKYDDQIKDHHEILPFIDDPVIFHKCHTMRRCFFNCILYQAVKYSKFSVLLYFKYILKENLPLVHSLIEKAYKYHNYEVIKWIYENLHIYDIINTFKCAIAHKDLRLYCLGYTFVYNRIVPYKYYHLDIRILLRLQLLHKVTAKGYLDFILETLKYDHNTNNIDIILTQAATYNHRNILTYFIPQSTYAQIEQCLFVAIKTNASKKTLNLLLSHLNLSIKLVKKLSQYVVAYKSTNIISILSRQQKKKIYLDIILTKVVKNAVFNKFVIGCMVTFSINPERIVKMAARIKKMKLVKNISEHVWKNHAVKLKYLKHAVHTMKHQEGKNRLMNFIYDHCYYHMQEEEIFSLARFYAIHHAPKLFDVFYDCCILDTIRFKSLLLDCSHIIVKNAHDASINIVNKYIGNLFAMGVLSKKEILQDYPSIYSKDYML*
SEQ ID No.150–肯尼亚1950MGF 505 1R蛋白
MFSLQNLCRKTLPDRKLPEFFDDYVLQLLGLYWENHGTIQRAGNNCVLIQQHNLIPVNEALRIAASEENYEIVSLLLAWEGNLYYAIIGALEGNRHNLIRKYDDQIKDHHEILPFIDDPVIFHKCHMMRRCFFNCILYQAVKYSKFSVLLYFKYILKENLPLVHSLIEKACEDHNYEVIKWIYENLHIYEIMDTFKCAIAHKDLHLYSLGYTFIYNRIVPYKYHHLDIRILSRLQLLHKVTAKGYLDFILETLKYDHNKDNINIILTQAATYNHRNILTYFIPQSTYAQIEQCLFVAIKTNASKKTLNLLLSHLNLSIKLVKKLSQYVVAYKSTNIISILSMQQKKKIYLDIILTKVVKNAIFIKFVIGCMVTFSINPERIVKMAARIKKMKLVKNISEHVWKNHAAKLKHLKHAVHTMKHQEGKNRLMNFIYDHCYYHMQGEEIFSLARFYAIHHAPKLFDVFYDCCILDTIRFKSLLLDCSYIIAKNAHDASINIVNKYIGNLFAMGVLSKKEILQDYPSIYSKDYML*
SEQ ID No.151–L60 MGF 505 1R蛋白
MFSLQNLCRKTLPDCKLPEFFDDYILQLLGLYWENHGTIQRAGNNCVLIQQHTLIPVNEALRIAASEENYEIVGLLLAWEGNLYYAIIGALEGNRYNLIRKYDDQIKDHHDILPFIDDPIIFHKCHIMRRCFFDCILYQAVKYSKFRVLLYFKYTLEDDLPLVHLLIEKACEDHNYEVIKWIYENLHVCHIIDTFDCAIAHKDLRLYCLGYTFIYNRIVPYKYHHLDILILSSLQLLHKVAAKGYLDFILETLKYDHNIDNLDVILTQAATYNHRKILTYFIPQSTYAQIEQCLFVAIKTKSSKKTLNLLLSHLNLSIKLIQKISQYVATFNSTNIIGILSMKRKKKIYLDIILTKFVKNAIFNKFVVRCMERFSINPERIVKMAARINKMMLVKKISEHVWKNHAARLKHLKHAVHTMKHKDGKNRLMNFIYEHCYYHMQGEEIFSLARFYAIHHAPKLFDVFYNCCILDTIRFKSLLLDCSHIIGKNAHDATNINIVNKYIGNLFAMGVLSKKEILQDYPSIYSKHYMP*
SEQ ID No.152–马拉维Lil-20/1(1983)MGF 505 1R蛋白
MFSLQNLCRKTLPDCKLPEFFDEYILQLLGLYWENHGTIQRAGNNCVLIQQHNLIPVNEALRIAASEENYEIVSLLLAWEGNLYYAIIGALEGNRPDLIRKYDDQIKDHHEILPFIDDPIIFHKCHIMRRCFFNCILYQAVKYSKFRVLLYFKHRLGDDLPLTHLLIEKACEDHNYEVIKWIYENLHSYNIMDTFECAIAHKDLRLYCLGYTFIYNRIVPYKYHHLDICILSSLQLLHKVAAKGYLDFILETLKYDHNINNIDIILTQAATYNHRKILTYFIPQLTYAQIEQCLLVAIKTKASKKTLNLLLSHLNLSIKLIKKISQYVVTYNSTNIISILSMRRKKKIYLDIILTEFVKNAIFNKFVVRCMDTFSINPERIVKMAARINRMMLVKNISERVWKNHAVKLKHLKHAVHTMKHQEGKNRLMNFIYDHCYYHMQGEEIFGLARFYAIHHAPKLFDVFYDCCMLDATRFKSLLLDCPHIIGKNAYDAGINLVNKYIGNLFAMGVLSKKEILQDYPSIYSKHDMF*
SEQ ID No.153–Mkuzi1979 MGF 505 1R蛋白
MFSLQNLCRKTLPDCKLPEFFDDYILQLLGLYWENHGTIQRAGNNCVLIQQHTLIPINEALRTAASEENYEIVSLLLAWEGNLYYAIIGALEGNRHDLIRKYDDQIKDHHEILPFIDDPVIFHKCHIMRRCFFDCILYQAVKYSKFRVLLYFKYRLEDDLPLTHLLIEKACENHNYEVIRWIYENLHIYNMIDTFECAIAHKDLRLYCLGYTFIYNRIVPNKYHHIDILILSSLQLLHKVAAKGYLDFILETLKYDHNNDNLDIILTQAATYNHRKILTYFIPQSTYAQIEQCLMVAIKTKSSKKTLNLLLSHLNLSIKLIKKISQYVVTYNSTNIIGILSMKRKKKIYLDILLTKFVKNAIFNKFVVRYMDTFSINPEKIVKMAARINKMMLVKKISEHIWKNHAARLEHLKHAVHTMKHKDGKNRLMNFIYEYCYYHMQGEEIFSLARFYAIHHAPKLFDVFYNCCILDTIRFKSLLLDCSHIIGKNAHDATNINIVNKYIDNLFAMGVLSKKEILQDYPSIYSKHYMP*
SEQ ID No.154–Pretorisuskop/96/4MGF 505 1R蛋白
MFSLQNLCRKTLPDCKLPEFFDEYILQLLGLYWENHGTIQRAGNNCVLVQQHTLIPVNEALRIAASEENYEIVSLLLAWEGNLYYAIIGALEGNRHDLIRKYDDQIKDHHEILPFIDNPVIFHKCHIMRRCFFDCILYQAVKYSKFRVLLYFKYRLENDLPLAHLLVEKACEDHNYEVIKWLYENLHIYNIMETFECAIAHKDLRLYRLGYTFIYNRIVPYKYHYLDVLILSGLHLLYKVAAKGYLDFILETLKYDHNNDNLDIILTQAVTYNHRKILTYYIPQLTYAQIEQCLFMAIKKKSSKKTLNLLLSHLKLSIKLIKKISQYVATYNSTNIIGILNMKRKKKIYLDIILTKFVKYAIFNKYVVRCMDTFSINPERIIKMAARINKMLLVKKISQHAWKNHAARLKHLKHAVYTMKHKDGKNRLMNLIYDHYYYHMQGEEIFSLARFYAIHHAPKLFDVFYDCCLLDTIRFKSLLLDCSHIIGKNAHDATNITIVNKYIGNLFAMGVLSKKEILQDYPSIYSKHYMP*
SEQ ID No.155–Tengani 62MGF 505 1R蛋白
MFSLQNLCRKTLPDCKLPEFFDEYILQLLGLYWENHGTIQRAGNNCVLIQQHNLIPVNEALRIAASEENYEIVSLLLAWEGNLYYAIIGALEGNRHDLIRKYDDQIKDHHEILPFIDDPVIFHKCHIMRQCFFDCILYQAVKYSKFRVLLSFKHRLRDDLPFTHLLIEKACKDHNYEVIKWIYENLHIYNMIDTFECAIAHKDLRLYCLGYRFIYNRIVPDKYHHLDIRMLSSLQLLHKVAAKGYLDFILETLKYDHNKDNINIILTQAATYNHRKILIYFIPQSTHAQIEQCLLVAIKTKSSKKTLNLLLSHLNLSINLIKKISHYVATYNSTNIIGILSMRRKKKIYLDIILTKFVKKAIFNKFVVRCMDTFSINPERILKIAARINRTMLVKKISEHVWKNHAVRLKYLKHAVHTMKHKDGKNRLMNFIYDRCYYHMQGEEIFSLARFYAIHHAPKLFDVFYDCCILDTIRFKSLLLDCSHIIGKNAHDATNINIVNKYIGNLFVMGVLSKKEILQDYPSIYSKHYMP*
SEQ ID No.156–Warmbaths MGF 505 1R蛋白
MFSLQNLCRKTLPDCKLPEFFDEYILQLLGLYWENHGTIQRAGNNCVLIQQRTLIPVNEALRIAASEENYEIVGLLLAWEGNLYYAIIGALEGNRHDLIRKYDDQIKDHHEILPFIDDPVIFHKCHIIRRCFFNCILYQAVKYSKFRVLLYFKHRLEDDLPLTHLLIEKACEDHNYEVIKWIYENLHTYDIMDTFECAIAHKDLRLYCLGYTFIYNRIVPYEYHHLDILILSSLQLLHKVAAKGYLDFILETLKYDHNNDNLDIILTQAATYNHRKILTYFIPQLTYAQIEQCLFMAIKRKSSKKTLNLLLSHLTLSIELIKKISQYVVTYNSTNIIGILSMKRKKKIYLDIMLTKYVKYAIFNKYVVRCMDRFSINPERIIKMAARINRMMLVKKISEHVWKNHAARLKHLKHAVHTMKHKDGKNRLMNFIYDRCYYHMQGEEIFSLARFYAIHHAPKLFDVFYDCCILDTIQFKSLLLDCSHIIGKNAHDATNINIVNKYIGDLFAMGVLSKKEILQDYPSIYSKHYML*
SEQ ID No.157–Warthog MGF 505 1R蛋白MFSLQNLCRKTLPDCKLPEFFDEYILQLLGLYWENHGTIQRAGNNCVLIQQHTLIPVNEALRIAASEENYEIVSLLLAWEGNLYYAIIGALEGNRHDLIRKYDDQIKDHHEILPFIDDPVIFHKCHIMRRCFFDCILYQAVKYSKFRVLLYFKYRLENDLPLAHLLIKKACEDHNYEVIKWIYENLHIYNIMDTFGCAIAHKDLRLYRLGYTFIYNRIVPYKYHYLDVLILSGLHLLYKVAAKGYLDFILETLKYDHNNDNLDIILTQAATYNHRKILTYYIPQLTYAQIEQCLFMAIKKKSSKKTLNLLLSHLKLSIKLIKKISQYVATYNSTNIIGILNMRRKKKIYLDIILTKFVKKAIFNKFVVRCMDTFSINPERIIKMAARINKMLLVKKISEHAWKNHAARLKHLKHAVYTMKHKDGKNRLMNLIYDHYYYHMQGEEIFSLARFYAIHHAPKLFDVFYDCCLLDTIRFKNLLLDCSHIIGKNAHDATNITIVNKYIGNLFAMGVLSKKEILQDYPSIYSKHYMP*
非洲猪瘟病毒格鲁吉亚2007/1致病性分离株的完整基因组在Genbank Locus:FR682468.1中给出。非洲猪瘟病毒贝宁97/1致病性分离株的完整基因组在Genbank Locus：AM712239.1中给出。完整的BA71分离株基因组编码151个开放阅读框(ORF)，贝宁97/1分离株编码157个ORF，OURT88/3分离株编码151个ORF。
IRF3和NF-κB活性的抑制
MGF基因MGF360-10L、11L、12L、13L和14L、MGF 505-1R、2R、3R、4R和5R以及MGF110-1L抑制转录因子干扰素调节因子3(IRF3)和NF-κB的活性，如本文的实施例2所证明(参见图1A和1B)。MGF360-12L通过抑制IRF3和NF-κB激活靶基因转录的能力特异性地抑制其活性(参见图1C和1D)。
IRF3和NF-κB是控制作为宿主先天免疫系统对病毒感染的反应的一部分的干扰素和促炎细胞因子的表达的转录因子。MGF基因对IRF3和NF-κB的抑制导致由感染ASFV的细胞产生的I型干扰素(IFN)和促炎细胞因子的量减少。MGF基因的表达使ASFV能够规避宿主先天免疫应答，从而有利于病毒复制并破坏适应性应答的进展。
MGF基因抑制IRF3和/或NF-κB活性的能力可以使用萤光素酶报告基因测定来测量，如本文实施例2中所述。例如，为了评估给定的MGF基因是否可以抑制IRF3或NF-κB活性，可以使MGF基因在包含处于由IRF3或NF-κB激活的启动子控制下的萤光素酶报告基因的细胞中表达，从而以分别激活IRF3或NF-κB的方式刺激细胞，然后测量萤光素酶活性。可以使用此类萤光素酶报告基因测定来评估MGF基因的修饰或突变形式抑制IRF3和/或NF-κB活性的能力。
K145R基因
K145R基因是晚期基因。
以下给出了来自不同ASFV毒株的K145R基因的基因(即核苷酸)序列。SEQ IDNo.158–贝宁97/1K145R(NC_044956.1:58961-59398)
ATGGATCATTATCTTAAAAAATTACAAGATATTTATACGAAGCTCGAGGGCCATCCCTTTCTTTTTAGCCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAGGCCTTGGCCTCAACGCAGCTTTACCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCCATTGGGTTTATTAACTATATTAAAACGAGTAAACAAGAGTATTTATGCCTGTTGATTAATCCTAAACTCGTTACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTCAGACTGAAAACTTTTTATATAAGTCCTAATAAGTATAATAATTTTTACACTGCTCCCTCTGAAGAAAAGACTAACCATCTCCTAAAAGAAGAAAAAACTTGGGCAAAGATTGTTGAAGAAGGAGGAGAAGAATCCTAA
SEQ ID No.159–中国/2018/安徽XCGQ K145R(MK128995.1:64748-65185)
ATGGATCATTATCTTAAAAAATTACAAGATATTTATACGAAGCTCGAGGGTCATCCCTTTCTTTTTAGCCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAGGCCTTGGCCTCAACGCAGCTTTACCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCCATTGGGTTTATTAACTATATTAAAACGAGTAAACAAGAGTATTTATGCCTGTTAATTAATCCTAAACTCGTTACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTCAGGCTGAAAACTTTTTATATAAGTCCTAATAAGTATAATAATTTTTACACCGCTCCCTCTGAAGAAAAGACTAACCATCTTCTAAAAGAAGAAAAAACTTGGGCAAAGATTGTTGAAGAAGGAGGAGAAGAATCCTAA
SEQ ID No.160–格鲁吉亚2007/1K145R(NC_044959.1:64734-65171)
ATGGATCATTATCTTAAAAAATTACAAGATATTTATACGAAGCTCGAGGGTCATCCCTTTCTTTTTAGCCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAGGCCTTGGCCTCAACGCAGCTTTACCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCCATTGGGTTTATTAACTATATTAAAACGAGTAAACAAGAGTATTTATGCCTGTTAATTAATCCTAAACTCGTTACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTCAGGCTGAAAACTTTTTATATAAGTCCTAATAAGTATAATAATTTTTACACCGCTCCCTCTGAAGAAAAGACTAACCATCTTCTAAAAGAAGAAAAAACTTGGGCAAAGATTGTTGAAGAAGGAGGAGAAGAATCCTAA
SEQ ID No.161–Ken05/Tk1 K145R(NC_044945.1:65442-65879)
ATGGATCATTATCTTAAAAAATTACAGGATATTTATAAGAAGCTTGAGGGTCACCCCTTTCTTTTTAGTCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAAGCCTTGGCCTCGACGCAGCTTTACCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCCATTGGGTTTGTTAACTATATTAAAGCGAGTAAACAAGAGTATTTATGTCTGTTGATTAATCCTAAACTAGTCACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTTAGGCTGAAAACTTTTTATATAAGTCCTAATAAGTATAATAATTTTTACATCGCTCCCTCTGAAGAAAAGGCCAATCATCTCCTAAAAGAAGAAAAAACCTGGGCAAAGATTGTTGAAGAAGGAGGAGAAGAATCCTAA
SEQ ID No.162–Ken06.Bus K145R(NC_044946.1:61226-61663)
ATGGATCATTATCTTAAAAAATTACAGGATATTTATAAGAAGCTTGAGGGTCACCCCTTTCTTTTTAGTCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAAGCCTTGGCCTCGACGCAGCTTTACCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCCATTGGGTTTGTTAACTATATTAAAGCGAGTAAACAAGAGTATTTATGTCTGTTGATTAATCCTAAACTAGTCACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTCAGGCTAAAAACTTTCTATATAAGTCCTAATAAGTATAATAATTTTTACATCGCTCCCTCTGAAGAAAAGGCCAATCATCTCCTAAAAGAAGAAAAAACCTGGGCAAAGATTGTTGAAGAAGGAGGAGAAGAATCCTAA
SEQ ID No.163–肯尼亚1950K145R(AY261360.1:68066-68503)
ATGGATCATTATCTTAAAAAATTACAGGATATTTATAAGAAGCTTGAGGGTCACCCCTTTCTTTTTAGTCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAAGCCTTGGCCTCGACGCAGCTTTACCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCCATTGGGTTTGTTAACTATATTAAAGCGAGTAAACAAGAGTATTTATGTCTGTTGATTAATCCTAAACTAGTCACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTTAGGCTGAAAACTTTTTATATAAGTCCTAATAAGTATAATAATTTTTACATCGCTCCCTCTGAAGAAAAGGCCAATCATCTCCTAAAAGAAGAAAAAACCTGGGCAAAGATTGTTGAAGAAGGAGGAGAAGAATCCTAA
SEQ ID No.164–L60 K145R(NC_044941.1:59310-59747)
ATGGATCATTATCTTAAAAAATTACAAGATATTTATACGAAGCTCGAGGGCCATCCCTTTCTTTTTAGCCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAGGCCTTGGCCTCAACGCAGCTTTACCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCCATTGGGTTTATTAACTATATTAAAACGAGTAAACAAGAGTATTTATGCCTGTTGATTAATCCTAAACTCGTTACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTCAGACTGAAAACTTTTTATATAAGTCCTAATAAGTATAATAATTTTTACACTGCTCCCTCTGAAGAAAAGACTAACCATCTCCTAAAAGAAGAAAAAACTTGGGCAAAGATTGTTGAAGAAGGAGGAGAAGAATCCTAA
SEQ ID No.165–马拉维Lil-20/1(1983)K145R(AY261361.1:62661-63098)
ATGGATCATTATCTTAAAAAATTAGAGGATATTTATAAAAAGCTTGAGGGTCATCCCTTTCTTTTTAGTCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGTTAAACCAAGCCTTGGCCTCAACGCAGCTTTATCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCCATTGGGTTTATTAACTATATTAAAACGAGTAAACAAGAGTATTTATGCCTGTTGATCAATCCTAAACTAGTTACGAAGTTTTTAAAAATAACGAGTTTTAAAATTTACATTAATTTCAGGCTGAAAACTTTTTATATAAGTCCTAATAAATATAATAATTTTTACACCGCTCCCTCTGAAGAAAAGGCCAATCATCTCCTAAAAGAAGAAAAAACCTGGGCAAAGATTGTTGAAGAAGGAGGAGAAGAATCCTAA
SEQ ID No.166–Mkuzi 1979K145R(AY261362.1:66481-66921)
ATGGATCATTATCTTAAAAAATTACAAGATATTTATACGAAGCTCGAGGGCCATCCCTTTCTTTTTAGCCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAGGCCTTGGCCTCAACGCAGCTTTACCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCTATAGGGTTTATTAACTATATTAAAACGAGTAAACAAGAGTATTTATGCCTGTTGATTAATCCTAAACTCGTTACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTCAGACTGAAAACTTTTTATATAAGTCCTAATAAGTATAATAATTTTTACACCGCTCCCTCTGAAGAAAAGACCAACCATCTCCTAAAAGAAGAAAAAACTTGGGCAAAGATTGTTGAAGAAGGAGGAGGAGAAGAATCCTAA
SEQ ID No.167–Pretorisuskop/96/4K145R(AY261363.1:65440-65877)
ATGGATCATTATCTTAAAAAATTACAAGAAATTTATACGAAGCTCGAGGGCCATCCCTTTCTTTTTAGCCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAGGCCTTGGCCTCAACGCAGCTTTATCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCCATTGGGTTTATTAACTATATTAAAACGAGTAAACAAGAGTATTTATGCCTGTTGATTAATCCTAAACTCGTCACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTCAGACTGAAAACTTTTTATATAAGTCCTAATAAGTATAATAATTTTTACACCGCTCCCTCTGAAGAAAAGACCAACCATCTCCTAAAAGAAGAAAAAACTTGGGCAAAGATTGTTGAAGAAGGAGGAGAAGAATCCTAA
SEQ ID No.168–Tengani 62K145R(AY261364.1:60111-60548)
ATGGATCATTATCTTAAAAAATTACAAGATATTTATACGAAGCTCGAGGGTCATCCCTTTCTTTTTAGCCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAGGCCTTGGCCTCAACGCAGCTTTACCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCCATTGGGTTTATTAACTATATTAAAACGAGTAAACAAGAGTATTTATGCCTGTTGATTAATCCTAAACTCGTTACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTCAGACTGAAAACTTTTTATATAAGTCCTAATAAGTATAATAATTTTTACACCGCTCCCTCTGAAGAAAAGACTAACCATCTCCTAAAAGAAGAAAAAACTTGGGCAAAGATTGTTGAAGAAGGAGGAGAAGAATCCTAA
SEQ ID No.169–Warmbaths K145R(AY261365.1:64642-65082)
ATGGATCATTATCTTAAAAAATTACAAGATATTTATACGAAGCTCGAGGGCCATCCCTTTCTTTTTAGCCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAGGCCTTGGCCTCAACGCAGCTTTACCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCTATAGGGTTTATTAACTATATTAAAACGAGTAAACAAGAGTATTTATGCCTGTTGATTAATCCTAAACTCGTTACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTCAGACTGAAAACTTTTTATATAAGTCCTAATAAGTATAATAATTTTTACACCGCTCCCTCTGAAGAAAAGACCAACCATCTCCTAAAAGAAGAAAAAACTTGGGCAAAGATTGTTGAAGAAGGAGGAGGAGAAGAATCCTAA
SEQ ID No.170–Warthog K145R(AY261366.1:61399-61836)
ATGGATCATTATCTTAAAAAATTACAAGATATTTATACGAAGCTCGAGGGCCATCCCTTTCTTTTTAGCCCGTCGAAAACCAATGAAAAAGAGTTTATTACTCTGCTAAACCAGGCCTTGGCCTCAACGCAGCTTTACCGCAGCATACAACAGCTGTTTTTAACGATGTATAAGCTAGATCCCATTGGGTTTATTAACTATATTAAAACGAGTAAACAAGAGTATTTATGCCTGTTGATTAATCCTAAACTCGTCACTAAGTTTTTAAAAATAACGAGCTTTAAAATTTACATTAATTTCAGACTGAAAACTTTTTATATAAGTCCTAATAAGTATAATAATTTTTACACCGCTCCCTCTGAAGAAAAGACCAACCATCTCCTAAAAGAAGAAAAAACTTGGGCAAAGATTGTTGAAGAAGGAGGAGAAGAATCCTAA
在实施方案中，本发明的减毒ASFV缺乏K145R基因的功能形式。适当地，K145R基因包含SEQ ID No.158、159、160、161、162、163、164、165、166、167、168、169或170的序列。适当地，K145R基因包含与SEQ ID No.158、159、160、161、162、163、164、165、166、167、168、169或170具有至少70％、至少80％、至少90％或至少95％的同一性的序列。适当地，K145R基因由SEQ ID No.158、159、160、161、162、163、164、165、166、167、168、169或170的序列组成。
下表3列出了来自不同ASFV毒株的K145R蛋白的登录号。
表3
| 毒株 | K145R蛋白登录号 |
| BA71V | Q07385 |
| PretoriuskopPr4/1996 | P0CA50 |
| Warthog | P0CA51 |
| 马拉维-Lil/20 | P0CA49 |
| 肯尼亚1950 | P0CA48 |
| 格鲁吉亚2007/1 | E0WM19 |
| 葡萄牙/OURT88/1988 | A9JLR1 |
| E75 | D4I5N9 |
| 贝宁97/1 | A9JKZ8 |
来自不同ASFV毒株的K145R蛋白的氨基酸序列如下所示。
SEQ ID No.171–贝宁97/1K145R蛋白
MDHYLKKLQDIYTKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFINYIKTSKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYTAPSEEKTNHLLKEEKTWAKIVEEGGEES*
SEQ ID No.172–中国/2018/安徽XCGQ蛋白
MDHYLKKLQDIYTKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFINYIKTSKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYTAPSEEKTNHLLKEEKTWAKIVEEGGEES*
SEQ ID No.9–格鲁吉亚2007/1K145R蛋白
MDHYLKKLQDIYTKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFINYIKTSKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYTAPSEEKTNHLLKEEKTWAKIVEEGGEES
SEQ ID No.173–Ken05/Tk1 K145R蛋白
MDHYLKKLQDIYKKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFVNYIKASKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYIAPSEEKANHLLKEEKTWAKIVEEGGEES*
SEQ ID No.174–Ken06.Bus K145R蛋白
MDHYLKKLQDIYKKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFVNYIKASKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYIAPSEEKANHLLKEEKTWAKIVEEGGEES*
SEQ ID No.175–肯尼亚1950K145R蛋白
MDHYLKKLQDIYKKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFVNYIKASKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYIAPSEEKANHLLKEEKTWAKIVEEGGEES*
SEQ ID No.176–L60 K145R蛋白
MDHYLKKLQDIYTKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFINYIKTSKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYTAPSEEKTNHLLKEEKTWAKIVEEGGEES*
SEQ ID No.177–马拉维Lil-20/1(1983)K145R蛋白
MDHYLKKLEDIYKKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFINYIKTSKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYTAPSEEKANHLLKEEKTWAKIVEEGGEES*
SEQ ID No.178–Mkuzi 1979K145R蛋白
MDHYLKKLQDIYTKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFINYIKTSKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYTAPSEEKTNHLLKEEKTWAKIVEEGGGEES*
SEQ ID No.179–Pretorisuskop/96/4K145R蛋白
MDHYLKKLQEIYTKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFINYIKTSKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYTAPSEEKTNHLLKEEKTWAKIVEEGGEES*
SEQ ID No.180–Tengani 62K145R蛋白
MDHYLKKLQDIYTKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFINYIKTSKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYTAPSEEKTNHLLKEEKTWAKIVEEGGEES*
SEQ ID No.181–Warmbaths K145R蛋白
MDHYLKKLQDIYTKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFINYIKTSKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYTAPSEEKTNHLLKEEKTWAKIVEEGGGEES*
SEQ ID No.182–Warthog K145R蛋白
MDHYLKKLQDIYTKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFINYIKTSKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYTAPSEEKTNHLLKEEKTWAKIVEEGGEES*
K145R抑制宿主内质网(ER)应激反应(Barber 2015Stress modulators encodedby African swine fever virus；PhD thesis,St Georges,伦敦大学，2016)。这种反应是由未折叠蛋白的积累引起的，并且可能在病毒感染期间由于产生大量病毒蛋白而被激活。ER应激导致转录因子CCAAT增强子结合蛋白同源蛋白(CHOP)的表达增加及其在细胞核中的积累。CHOP活性最终导致细胞凋亡，从而限制病毒复制。
K145R功能可以通过以下方法进行测试，包括使用针对CHOP的抗体的免疫荧光并在诱导ER应激后评估其在细胞核中的存在，以及萤光素酶报告基因测定，其中萤光素酶基因在CHOP启动子的控制下。
B125R基因
以下给出了来自不同ASFV毒株的B125R基因的基因(即核苷酸)序列。SEQ IDNo.183–贝宁97/1B125R(NC_044956.1:100206-100583)
ATGGCGGTTTATGCGAAGGATCTTGATAATAACAAAGAGTTAAACCAAAAATTAATTAACGATCAGCTTAAAATTATTGACACGCTCTTGCTAGCAGAAAAAAAAAACTTTTTGGTGTATGAATTGCCTGCCCCTTTTGACTTTTCCTCCGGCGACCCTTTGGCCAGTCAGCGCGACATATACTATGCCATCATAAAAAGCCTCGAGGAGCGCGGGTTTACTGTCAAAATATGTATGAAAGGGGATCGTGCCCTCCTTTTCATCACTTGGAAAAAAATACAATCCATTGAGATAAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAAGCATTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.184–中国/2018/安徽XCGQ B125R(MK128995.1:105587-105964)
ATGGCGGTTTATGCGAAGGATCTTGATAATAACAAAGAGTTAAACCAAAAATTAATTAACGATCAGCTTAAAATTATTGACACGCTCTTGCTGGCAGAAAAAAAAAACTTTTTGGTGTATGAACTACCTGCCCCTTTTGACTTTTCCTCCGGCGACCCTTTGGCCAGTCAGCGCGACATATACTATGCCATCATAAAAAGCCTCGAGGAGCGCGGGTTTACTGTCAAAATATGTATGAAAGGGGATCGTGCCCTCCTTTTCATCACCTGGAAAAAAATACAATCCATTGAGATAAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAAGCATTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.185–格鲁吉亚2007/1B125R(NC_044959.1:105570-105947)
ATGGCGGTTTATGCGAAGGATCTTGATAATAACAAAGAGTTAAACCAAAAATTAATTAACGATCAGCTTAAAATTATTGACACGCTCTTGCTGGCAGAAAAAAAAAACTTTTTGGTGTATGAACTACCTGCCCCTTTTGACTTTTCCTCCGGCGACCCTTTGGCCAGTCAGCGCGACATATACTATGCCATCATAAAAAGCCTCGAGGAGCGCGGGTTTACTGTCAAAATATGTATGAAAGGGGATCGTGCCCTCCTTTTCATCACCTGGAAAAAAATACAATCCATTGAGATAAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAAGCATTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.186–Ken05/Tk1 B125R(NC_044945.1:106516-106893)
ATGGCGGTTTATGCGAAGGACCTTGATAATAACAAAGAGTTAAACCAAAAATTGATCAACGATCAGCTTAAAATCATTGACACGCTTTTGCTAGCAGAAAAAAAAAACTTTTTGGTGTACGAACTACCTGCCCATTTTGACTTTTCCTCCGGCGACCCTTTGGGCAGTCAGCGCGACATTTACTATGCCATCATAAAAAGTCTCGAGGAGCGCGGATTTACTGTCAAAATATGTATGAAGGGAGACCGCGCCCTTCTTTTCATCACCTGGAAAAAAATACAATCCATTGAGATCAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAAGCGTTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.187–Ken06.Bus B125R(NC_044946.1:102432-102809)
ATGGCGGTTTATGCGAAGGACCTTGATAATAACAAAGAGTTAAACCAAAAATTGATCAACGATCAGCTTAAAATTATTGACACGCTTTTGCTGGCAGAAAAAAAAAACTTTTTGGTGTACGAACTACCTGCCCATTTTGACTTTTCCTCCGGCGACCCTTTGGGCAGTCAGCGCGACATTTACTATGCCATCATAAAAAGTCTCGAGGAGCGCGGATTTACTGTCAAAATATGTATGAAGGGAGACCGCGCCCTTCTTTTCATCACCTGGAAAAAAATACAATCCATTGAGATCAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAAGCGTTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.188–肯尼亚1950B125R(AY261360.1:109401-109778)
ATGGCGGTTTATGCGAAGGACCTTGATAATAACAAAGAGTTAAACCAAAAATTGATCAACGATCAGCTTAAAATCATTGACACGCTTTTGCTAGCAGAAAAAAAAAACTTTTTGGTGTACGAACTACCTGCCCATTTTGACTTTTCCTCCGGCGACCCTTTGGGCAGTCAGCGCGACATTTACTATGCCATCATAAAAAGTCTCGAGGAGCGCGGATTTACTGTCAAAATATGTATGAAGGGAGACCGCGCCCTTCTTTTCATCACCTGGAAAAAAATACAATCCATTGAGATCAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAAGCGTTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.189–L60 B125R(NC_044941.1:100308-100685)
ATGGCGGTTTATGCGAAGGATCTTGATAATAACAAAGAGTTAAACCAAAAATTAATTAACGATCAGCTTAAAATTATTGACACGCTCTTGCTAGCAGAAAAAAAAAACTTTTTGGTGTATGAATTGCCTGCCCCTTTTGACTTTTCCTCCGGCGACCCTTTGGCCAGTCAGCGCGACATATACTATGCCATCATAAAAAGCCTCGAGGAGCGCGGGTTTACTGTCAAAATATGTATGAAAGGGGATCGTGCCCTCCTTTTCATCACTTGGAAAAAAATACAATCCATTGAGATAAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAAGCATTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.190–马拉维Lil-20/1(1983)B125R(AY261361.1:103937-104314)
ATGGCAGTTTATGCGAAAGATCTTGATAATAACAAAGAGTTAAACCAAAAATTAATTAACGATCAACTTAAAATTATTGACACGCTGTTGCTGGCAGAAAAAAAAAACTTTTTGGTGCATGAACTACCTGCCCACTATGACTTTTCCTCCGGCGACCCTTTGGCCAGTCAGCGCGACATATACTATGCCATCATAAAAAGTCTCGAGGAGCGCGGATTTACTGTCAAAATTTGTATGAAAGGAGATCGCGCCCTTCTTTTCATCACCTGGAAAAAAATACAATCCATTGAGATAAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGATGAAGAGAAAGCATTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.191–Mkuzi 1979B125R(AY261362.1:107379-107756)
ATGGCGGTTTATGCGAAGGATCTTGATAATAACAAAGAGTTAAACCAAAAATTAATTAACGATCAGCTTAAAATTATTGACACGCTCTTGCTAGCAGAAAAAAAAAACTTTTTGGTGTATGAATTGCCTGCCCCTTTTGACTTTTCCTCCGGCGACCCTTTGGCCAGTCAGCGCGACATATACTATGCCATCATAAAAAGCCTCGAGGAGCGCGGGTTTACTGTCAAAATATGTATGAAAGGGGATCGTGCCCTCCTTTTCATCACTTGGAAAAAAATACAATCCATTGAGATAAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAAGCATTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.192–Pretorisuskop/96/4B125R(AY261363.1:106504-106881)
ATGGCGGTTTATGCGAAGGATCTTGATAATAACAAAGAGTTAAACCAAAAATTAATTAACGATCAGCTTAAAATTATTGACACGCTCTTGCTGGCAGAAAAAAAAAACTTTTTGGTGTATGAACTACCTGCCCCTTTTGACTTTTCCTCCGGCGACCCTTTGGCCAGTCAGCGCGACATATACTATGCCATCATAAAAAGTCTCGAGGAGCGCGGGTTTACTGTCAAAATATGTATGAAAGGGGATCGCGCCCTCCTTTTCATCACCTGGAAAAAAATACAATCCATTGAGATAAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAAGCATTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.193–Tengani 62B125R(AY261364.1:100837-101214)
ATGGCGGTGTATGCGAAGGACCTTGATAATAACAAAGAGTTAAACCAAAAATTAATTAACGATCAGCTTAAAATTATTGACACGCTCTTGCTGGCAGAAAAAAAAAACTTTTTGGTGTATGAACTACCTGCCCCTTTTGACTTTTCCTCCGGCGACCCTTTGGCCAGTCAGCGTGACATATACTATGCCATCATAAAAAGTCTTGAGGAGCGCGGGTTTACTGTCAAAATATGTATGAAAGGGGATCGTGCCCTCCTTTTCATCACCTGGAAAAAAATACAATCCATTGAAATAAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAATCATTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.194–Warmbaths B125R(AY261365.1:105532-105909)
ATGGCGGTTTATGCGAAGGATCTTGATAATAACAAAGAGTTAAACCAAAAATTAATTAACGATCAGCTTAAAATTATTGACACGCTCTTGCTGGCAGAAAAAAAAAACTTTTTGGTGTATGAACTACCTGCCCCTTTTGACTTTTCCTCCGGCGACCCTTTGGCCAGTCAGCGCGACATATACTATGCCATCATAAAAAGTCTCGAGGAGCGCGGGTTTACTGTCAAAATATGTATGAAAGGGGATCGCGCCCTCCTTTTCATCACCTGGAAAAAAATACAATCCATTGAGATAAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAAGCATTTTATTGTAAATTTTTAGAGTCTAGATGA
SEQ ID No.195–Warthog B125R(AY261366.1:102258-102635)
ATGGCGGTTTATGCGAAGGACCTTGATAATAACAAAGAGTTAAACCAAAAATTAATTAACGATCAGCTTAAAATTATTGACACGCTCTTGCTGGCAGAAAAAAAAAACTTTTTGGTGTATGAACTACCTGCCCCTTTTGACTTTTCCTCCGGCGACCCTTTGGCCAGTCAGCGCGACATATACTATGCCATCATAAAAAGTCTCGAGGAGCGCGGGTTTACTGTCAAAATATGTATGAAAGGGGATCGCGCCCTCCTTTTCATCACCTGGAAAAAAATACAATCCATTGAGATAAACAAAAAAGAAGAATATCTGCGCATGCACTTCATACAAGACGAAGAGAAAGCATTTTATTGTAAATTTTTAGAGTCTAGATGA
在实施方案中，本发明的减毒ASFV缺乏B125R基因的功能形式。适当地，B125R基因包含SEQ ID No.183、184、185、186、187、188、189、190、191、192、193、194或195的序列。适当地，B125R基因包含与SEQ ID No.183、184、185、186、187、188、189、190、191、192、193、194或195具有至少70％、至少80％、至少90％或至少95％的同一性的序列。适当地，B125R基因由SEQ ID No.183、184、185、186、187、188、189、190、191、192、193、194或195的序列组成。
下表4列出了来自不同ASFV毒株的B125R蛋白的登录号。
表4
| 毒株 | B125R蛋白登录号 |
| BA71V | Q65171 |
| PretoriuskopPr4/1996 | P0CA34 |
| Warthog | P0CA35 |
| 格鲁吉亚2007/1 | E0WMM1 |
| 葡萄牙/OURT88/1988 | A9JLX0 |
| E75 | D4I5S1 |
| 贝宁97/1 | A9JL41 |
来自不同ASFV毒株的B125R蛋白的氨基酸序列如下所示。
SEQ ID No.196–贝宁97/1B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAPFDFSSGDPLASQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR*
SEQ ID No.197–中国/2018/安徽XCGQ B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAPFDFSSGDPLASQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR*
SEQ ID No.10–格鲁吉亚2007/1B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAPFDFSSGDPLASQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR
SEQ ID No.198–Ken05/Tk1 B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAHFDFSSGDPLGSQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR*
SEQ ID No.199–Ken06.Bus B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAHFDFSSGDPLGSQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR*
SEQ ID No.200–肯尼亚1950B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAHFDFSSGDPLGSQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR*
SEQ ID No.201–L60 B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAPFDFSSGDPLASQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR*
SEQ ID No.202–马拉维Lil-20/1B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVHELPAHYDFSSGDPLASQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR*
SEQ ID No.203–Mkuzi 1979B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAPFDFSSGDPLASQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR*
SEQ ID No.204–Pretorisuskop/96/4B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAPFDFSSGDPLASQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR*
SEQ ID No.205–Tengani 62B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAPFDFSSGDPLASQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKSFYCKFLESR*
SEQ ID No.206–Warmbaths B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAPFDFSSGDPLASQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR*
SEQ ID No.207–Warthog B125R蛋白
MAVYAKDLDNNKELNQKLINDQLKIIDTLLLAEKKNFLVYELPAPFDFSSGDPLASQRDIYYAIIKSLEERGFTVKICMKGDRALLFITWKKIQSIEINKKEEYLRMHFIQDEEKAFYCKFLESR*
B125R被鉴定为在受感染的野猪细胞(WSL-R)中表达最丰富的病毒蛋白之一(Kaβler等人2018Sci.Rep.8:1471)。
如图11所示，可以在细胞表面检测到B125R表达，表明B125R可能暴露于抗体并可能诱导强烈的抗体反应。
表达和活性
本发明一个实施方案的减毒非洲猪瘟(ASF)病毒破坏了以下基因的表达和/或活性：
MGF 360基因12L、13L和14L；以及
MGF 505基因1R。
这些基因在本文中可称为“被破坏的基因”。
表达
在实施方案中，本发明提供了减毒非洲猪瘟(ASF)病毒，其中以下基因的表达被破坏：
多基因家族(MGF)360 12L、13L和14L，以及
MGF 505 1R。
关于基因的术语“表达”是指ASF病毒产生基因产物如RNA和/或蛋白质的能力。基因表达的破坏意味着基因产物的产生减少。基因的表达可以降低至少50％、至少60％、至少70％、至少80％、至少90％和/或至少95％。基因的表达可以降低到基因产物如RNA和/或蛋白质的产生被完全消除(即基因产物根本不产生)的程度。相对于未被破坏时的基因表达，基因表达的破坏减少基因的表达。例如，相较于基因的野生型形式，突变基因可以具有降低的表达。
表达被破坏的基因可能无法完全转录和翻译。基因的转录可以减少至少50％、至少60％、至少70％、至少80％、至少90％和/或至少95％。基因的转录可以被消除(即基因可以不转录)。基因的翻译可以减少至少50％、至少60％、至少70％、至少80％、至少90％和/或至少95％。基因的翻译可以被消除。基因可以转录但不翻译。基因可以转录和翻译，但蛋白质过快降解而无法发挥其功能。基因可以转录和翻译，但蛋白质可以没有功能。
基因表达可以通过本领域已知的技术来测量。例如，可以如通过使用定量聚合酶链式反应(qPCR)来量化从基因转录的mRNA量。替代性地或另外地，可以如通过使用蛋白质印迹法或质谱法来定量蛋白质的量。
活性
在实施方案中，本发明提供了减毒非洲猪瘟(ASF)病毒，其中以下基因的活性被破坏：
多基因家族(MGF)360 12L、13L和14L，以及
MGF 505 1R。
关于基因的术语“活性”是指基因执行其功能的能力。不同的基因具有不同的活性，即它们实现不同的功能。给定的基因可以具有多种活性；基因活性的破坏是指一种或多种这些活性的破坏。基因的一种或多种活性可以被破坏，而一种或多种其他活性不被破坏。相对于未被破坏时的基因活性，基因活性的破坏降低基因的活性。例如，相较于基因的野生型形式，突变基因可以具有降低的活性。基因活性可以降低到基因活性完全消除的程度。
根据本发明的减毒ASFV可以包含被破坏基因的非功能形式。
基因表达的破坏也可以破坏该基因的活性，因为基因产物量的减少意味着基因不能有效地执行其活性的一种或多种。
在实施方案中，被破坏的基因的活性是该基因抑制IRF3和/或NFκB活性的能力。在实施方案中，本发明提供了减毒非洲猪瘟(ASF)病毒，其中以下基因抑制IRF3和/或NFκB活性的能力被破坏：
多基因家族(MGF)360 12L、13L和14L，以及
MGF 505 1R。
在实施方案中，本发明提供减毒ASF病毒，其中MGF 360 12L、13L和14L以及MGF505 1R基因抑制IRF3活性的能力被破坏。在实施方案中，本发明提供减毒ASF病毒，其中MGF360 12L、13L和14L以及MGF 505 1R基因抑制NFκB活性的能力被破坏。MGF 360 12L、13L和14L和/或MGF505 1R抑制IRF3和/或NFκB活性的能力可以使用如本文所述的萤光素酶报告基因测定来测量。
抑制IRF3和/或NFκB活性的能力的破坏意味着抑制IRF3和/或NFκB活性的能力降低。换言之，本发明的减毒ASF病毒中的MGF基因形式对IRF3和/或NFκB活性的抑制低于相同MGF基因的野生型形式。抑制IRF3和/或NFκB活性的能力可以降低至少50％、至少60％、至少70％、至少80％或至少90％。在实施方案中，可以消除MGF基因抑制IRF3和/或NFκB活性的能力，即MGF基因不抑制IRF3和/或NFκB活性。在这种情况下，IRF3和/或NFκB的活性将与不存在MGF基因时一样高。抑制作用的降低意味着IRF3和/或NFκB活性高于野生型形式MGF基因下的活性。IRF3和/或NFκB活性可以是野生型形式MGF基因下的活性的两倍高，如三倍高、四倍高、五倍高或六倍高。
IRF3和NFκB是激活各种基因转录的转录因子，控制作为宿主对病毒感染的先天免疫系统应答的一部分的干扰素和促炎细胞因子的表达。IRF3和/或NFκB活性的抑制意味着降低其靶基因表达的激活。IRF3和/或NFκB靶基因表达的激活程度可以使用萤光素酶报告基因测定来测量，其中IRF3可激活启动子或NFκB可激活启动子与萤光素酶报告基因连接。
适当地，MGF 360 12L抑制IRF3活性的能力被破坏。适当地，MGF 36013L抑制IRF3活性的能力被破坏。适当地，MGF 360 14L抑制IRF3活性的能力被破坏。适当地，MGF 505 1R抑制IRF3活性的能力被破坏。适当地，MGF 360 12L抑制NFκB活性的能力被破坏。适当地，MGF 360 13L抑制NFκB活性的能力被破坏。适当地，MGF 360 14L抑制NFκB活性的能力被破坏。适当地，MGF 505 1R抑制NFκB活性的能力被破坏。
IRF3和NFκB通过与靶标DNA结合并激活转录来发挥作用。MGF基因可以通过抑制IRF3和/或NFκB激活转录的能力来抑制IRF3和/或NFκB活性。在实施方案中，MGF 360 12L抑制通过IRF3和/或NFκB的转录激活的能力被破坏。适当地，MGF 360 12L抑制通过IRF3的转录激活的能力被破坏。适当地，MGF 360 12L抑制通过NFκB的转录激活的能力被破坏。
破坏表达和/或活性的突变
基因的表达和/或活性通过使ASFV基因组突变，即通过使ASFV基因组的核苷酸序列突变来破坏。“突变”是指ASFV基因组的核苷酸序列相对于已知ASFV基因型的变化。突变包括将一个或多个核苷酸改变为不同的核苷酸(即取代)、添加核苷酸、缺失核苷酸和/或这些的组合。
在实施方案中，本发明的减毒ASF病毒包含破坏以下基因的表达和/或活性的突变：
MGF 360基因12L、13L和14L；以及
MGF 505基因1R。
基因的表达和/或活性可以通过破坏基因转录成mRNA来破坏，即通过减少基因转录如完全消除基因转录来破坏。基因的表达和/或活性可以通过破坏mRNA翻译成蛋白质来破坏。在实施方案中，减毒ASF病毒包含降低基因转录和/或翻译的突变。在实施方案中，减毒ASF病毒包含导致基因不转录和/或翻译(即完全消除转录和/或翻译)的突变。
基因的表达和/或活性可以通过使与基因相关的非编码序列如启动子突变来破坏。在实施方案中，减毒ASF病毒包含一个或多个被破坏基因的启动子中的突变。
基因的表达和/或活性可以通过使一个或多个被破坏基因的编码序列突变来破坏。
基因的功能形式
本发明的减毒ASFV包含以下基因的功能形式：
(i)MGF 360 10L和/或11L，以及
(ii)MGF 505 2R和/或3R。
适当地，本发明的减毒ASFV包含MGF 360 10L和11L的功能形式。适当地，本发明的减毒ASFV包含MGF 505 2R和3R的功能形式。适当地，本发明的减毒ASFV包含MGF 360 10L以及MGF 505 2R的功能形式。适当地，本发明的减毒ASFV包含MGF 360 10L以及MGF 505 3R的功能形式。适当地，本发明的减毒ASFV包含MGF 360 11L以及MGF 505 2R的功能形式。适当地，本发明的减毒ASFV包含MGF 360 11L以及MGF 505 3R的功能形式。适当地，本发明的减毒ASFV包含MGF 360 10L以及MGF 505 2R和3R的功能形式。适当地，本发明的减毒ASFV包含MGF 360 11L以及MGF 505 2R和3R的功能形式。适当地，本发明的减毒ASFV包含MGF 36010L和11L以及MGF 505 2R的功能形式。适当地，本发明的减毒ASFV包含MGF 360 10L和11L以及MGF 505 3R的功能形式。适当地，本发明的减毒ASFV包含MGF 360 10L和11L以及MGF505 2R和3R的功能形式。
在实施方案中，本发明的减毒ASFV包含缺乏K145R基因的功能形式和/或缺乏B125R基因的功能形式的DIVA突变。
在另一方面，本发明提供了缺乏K145R基因和/或B125R基因的功能形式的减毒ASFV。
表述基因的“功能形式”是指其表达和活性未被破坏的基因。换言之，基因的功能形式不以破坏基因表达或基因活性的方式发生突变。基因的功能形式可以不包含任何突变。基因的功能形式的编码序列可以是完整且不间断的。基因的功能形式可以完全转录和翻译。
MGF基因的功能可以指其抑制IRF3和/或NFκB活性的能力。MGF基因的功能形式可以抑制IRF3和/或NFκB活性。在实施方案中，本发明的减毒ASFV包含抑制IRF3和/或NFκB活性的以下基因的形式：
(i)MGF 360 10L和/或11L，以及
(ii)MGF 505 2R和/或3R。
MGF 360 10L和/或11L以及MGF 505 2R和/或3R抑制IRF3和/或NFκB活性的能力可以使用如本文所述的萤光素酶报告基因测定来测量。
基因的功能形式可以对应于野生型ASFV分离株中的基因。基因的功能形式可以对应于强毒ASFV毒株中的基因。基因的功能形式的序列可以与野生型ASFV分离株或强毒ASFV毒株中的基因序列相同。基因的功能形式的序列可以与衍生出本发明的减毒ASFV的野生型ASFV分离株中的基因序列相同。基因的功能形式可以是野生型ASFV分离株中基因的天然变体。
基因的功能形式可以包含突变。但是，突变不应破坏基因的表达或活性。换言之，突变不应影响基因的功能。基因的功能形式可以包含一个或多个同义突变(即不改变基因编码的蛋白质的氨基酸序列的突变)。基因的功能形式可以包含一个或多个沉默突变，该沉默突变可以是同义的或非同义的。基因的功能形式可以包含不破坏基因的表达或活性的缺失。基因的功能形式可以包含一种或多种不破坏基因的表达或活性的单核苷酸多态性(SNP)。
基因的功能形式的缺乏
缺乏基因的功能形式的减毒ASFV可以不表达该基因，即该基因可能无法正确转录和翻译。基因可以不转录。基因可以转录但不翻译。基因可以转录和翻译，但蛋白质过快降解而无法发挥其功能。基因可以转录和翻译，但蛋白质可以没有功能。
基因表达可以通过本领域已知的技术来测量。例如，可以如通过使用定量聚合酶链式反应(qPCR)来量化从基因转录的mRNA量。替代性地或另外地，可以如通过使用蛋白质印迹法或质谱法来定量蛋白质的量。
缺乏基因的功能形式的减毒ASFV可以包含导致ASFV不表达该基因的突变。突变可以是如本文所述的缺失。突变可以是如本文所述的中断。
K145R基因的功能形式的缺乏可以意味着K145R基因抑制宿主内质网(ER)应激反应的能力降低。K145R功能可以通过以下方法进行测试，包括使用针对CHOP的抗体的免疫荧光并在诱导ER应激后评估其在细胞核中的存在，以及萤光素酶报告基因测定，其中萤光素酶基因在CHOP启动子的控制下。
DIVA突变
在实施方案中，本发明的减毒ASFV包含区分感染和免疫动物(DIVA)的突变。适当地，DIVA突变缺乏K145R基因的功能形式和/或缺乏B125R基因的功能形式。
在实施方案中，本发明提供了减毒ASFV，其中以下基因的表达和/或活性被破坏：
多基因家族(MGF)360 12L、13L和14L，以及
MGF 505 1R；
该ASFV包含以下基因的功能形式：
(i)MGF 360 10L和/或11L，以及
(ii)MGF 505 2R和/或3R；
并且该ASFV包含DIVA突变。
在实施方案中，本发明提供了减毒ASFV，其中以下基因的表达和/或活性被破坏：
多基因家族(MGF)360 12L、13L和14L，以及
MGF 505 1R；
该ASFV包含以下基因的功能形式：
(i)MGF 360 10L和/或11L，以及
(ii)MGF 505 2R和/或3R；
并且该ASFV缺乏K145R基因和/或B125R基因的功能形式。
在另一方面，本发明提供了缺乏K145R基因和/或B125R基因的功能形式的减毒ASFV。适当地，本发明的减毒ASFV缺乏K145R基因的功能形式。适当地，本发明的减毒ASFV缺乏B125R基因的功能形式。
在另一方面，本发明提供了缺乏DP148R基因的功能形式并包含DIVA突变的减毒ASFV。在实施方案中，本发明的减毒ASFV缺乏以下基因的功能形式：
(i)DP148R；和
(ii)K145R和/或B125R。
在实施方案中，本发明的减毒ASFV可以缺乏DP148R基因和K145R基因的功能形式。在实施方案中，本发明的减毒ASFV可以缺乏DP148R基因和B125R基因的功能形式。适当地，DP148R基因部分或完全缺失。适当地，K145R基因部分或完全缺失。适当地，B125R基因部分或完全缺失。在减毒ASFV的实施方案中，以下基因完全缺失：DP148R和K145R。在减毒ASFV的实施方案中，以下基因完全缺失：DP148R和B125R。
缺失
在本发明的减毒ASFV中，基因的表达和/或活性可以通过缺失而被破坏。换言之，基因的表达和/或活性可以通过作为缺失的突变而被破坏。
本发明的减毒ASFV可以通过缺失而缺少基因的功能形式。换言之，导致ASFV缺乏基因功能形式的突变可以是缺失。
“缺失”是指去除部分ASFV基因组核苷酸序列。缺失可以是连续的，或者可以包含多个序列片段的缺失。缺失可以以本文所述的任何方式破坏基因的表达和/或活性。缺失可以导致ASFV以本文所述的任何方式缺乏基因的功能形式。
缺失可以破坏基因转录成mRNA。例如，缺失基因的启动子会破坏转录。缺失可以破坏mRNA翻译为蛋白质。例如，缺失启动密码子会破坏翻译。基因的表达和/或活性可以通过缺失与基因相关的非编码序列如启动子而被破坏。
基因的表达和/或活性可以通过缺失基因的编码序列而被破坏。通过缺失基因的编码序列，可以使ASFV缺乏基因的功能形式。编码序列的缺失可以是部分的(即编码序列的部分缺失)。缺失可以例如去除基因编码序列的至少50％、60％、70％、80％或90％。缺失可以是完全的，在这种情况下，与野生型分离株的相应基因组相比，该基因的编码序列100％不存在。
编码序列的缺失可以是连续的，或者可以包含编码序列的多个部分的缺失。缺失应去除足够量的编码序列使得缺失破坏基因的表达和/或活性，即不再从基因产生功能性基因产物如蛋白质。表述“基因缺失”(如“部分缺失”)是指缺失足够量的编码序列，从而破坏基因的表达和/或活性。需要缺失以破坏基因的表达和/或活性的编码序列的量可以非常少。例如，仅缺失起始密码子(ATG)可能足以破坏基因的表达和/或活性以使病毒减毒。
可以使用本领域已知技术进行基因的部分和全部缺失，如通过Cre-LoxP和Flp-FRT系统的条件靶向，或通过使用工程化核酸酶如大范围核酸酶、锌指核酸酶(ZFN)、转录激活因子样效应核酸酶(TALEN)和CRISPR-Cas系统中的Cas诱导双链断裂(DSB)和修复。DSB修复可用于通过提供包含与DSB任一侧的序列同源的序列中的期望突变核苷酸序列的载体来引入所期望的突变。这导致期望的突变插入到DSB的位点。可以对上述核酸酶进行工程改造，以在基因组内的特定位点诱导DSB。例如，可以通过组合已知的蛋白质单元以识别感兴趣的基因或基因组区域内的靶识别序列而容易地生成嵌合大范围核酸酶。ZFN也可以设计以靶向特定序列，例如将具有已知特异性的锌指单元组合以结合DNA的特定区域。TALEN是通过将核酸酶结构域与DNA结合TALE(转录激活因子样效应物)结构域融合而设计的人工限制酶。TALE结构域是识别单个核苷酸的氨基酸重复序列的串联阵列，可以设计以靶向DNA的特定区域。CRISPR-Cas系统由Cas(CRISPR相关蛋白)核酸酶和CRISPR(成簇规则间隔短回文重复序列)RNA序列组成，该序列指导Cas蛋白识别和切割与CRISPR序列互补的特定DNA链。因此，单链引导RNA(sgRNA)可以设计以结合DNA的特定区域并引导Cas引入DSB。因此，只要已知基因的核苷酸(例如DNA或cDNA)序列，就可以利用已知的核酸酶系统将部分或全部缺失引入基因。
在本发明的减毒ASF病毒的实施方案中，以下基因可以至少部分缺失：
MGF 360基因12L、13L和14L；以及
MGF 505基因1R。
一个或多个(如两个或多个、三个或多个或所有四个)被破坏的基因可以至少部分缺失。一个或多个(如两个或多个、三个或多个或所有四个)被破坏的基因的编码序列可以至少部分缺失。
在本发明的减毒ASF病毒的实施方案中，以下基因可以完全缺失：
MGF 360基因12L、13L和14L；以及
MGF 505基因1R。
一个或多个(如两个或多个、三个或多个或所有四个)被破坏的基因可以完全缺失。一个或多个(如两个或多个、三个或多个或所有四个)被破坏的基因的编码序列可以完全缺失。
在实施方案中，本发明的减毒ASFV缺乏K145R基因和/或B125R基因的功能形式。基因可以全部或部分缺失。基因的编码序列可以全部或部分缺失。适当地，K145R基因编码序列全部或部分缺失。适当地，B125R基因编码序列全部或部分缺失。
在实施方案中，本发明的减毒ASFV缺乏K145R基因和/或B125R基因的功能形式。K145R基因和/或B125R基因可以全部或部分缺失。基因的编码序列可以部分或完全缺失。适当地，K145R基因编码序列部分或完全缺失。适当地，B125R基因编码序列部分或完全缺失。
在本发明的减毒ASFV的实施方案中，以下基因可以至少部分缺失：
MGF 360基因12L、13L和14L；
MGF 505基因1R；以及
K145R基因和/或B125R基因。
一个或多个(如两个或多个、三个或多个、四个或多个、五个或多个或全部六个)基因可以至少部分缺失。基因中的一个或多个(如两个或多个、三个或多个、四个或多个、五个或多个或全部六个)的编码序列可以至少部分缺失。
在本发明的减毒ASFV的实施方案中，以下基因可以完全缺失：
MGF 360基因12L、13L和14L；
MGF 505基因1R；以及
K145R基因和/或B125R基因。
一个或多个(如两个或多个、三个或多个、四个或多个、五个或多个或全部六个)基因可以完全缺失。一个或多个(如两个或多个、三个或多个、四个或多个、五个或多个或所有六个)基因的编码序列可以完全缺失。
中断
基因的表达和/或活性可以通过基因的中断而被破坏。换言之，破坏基因的表达和/或活性的突变可以是中断基因的突变。
本发明的减毒ASFV可以通过基因的中断而缺失基因的功能形式。换言之，导致ASFV缺乏基因的功能形式的突变可以是中断基因的突变。
在本发明的减毒ASFV的实施方案中，以下基因可以被中断：
MGF 360基因12L、13L和14L；以及
MGF 505基因1R。
一个或多个(如两个或多个、三个或多个、或全部四个)基因可以被中断。
在本发明的减毒ASF病毒的另一个实施方案中，K145R基因和/或B125R基因可以被中断。适当地，K145R基因可以被中断。适当地，DP148R基因可以被中断。
在本发明的减毒ASFV的实施方案中，以下基因可以被中断：
MGF 360基因12L、13L和14L；
MGF 505基因1R；以及
K145R基因和/或B125R基因。
一个或多个(如两个或多个、三个或多个、四个或多个、五个或多个或所有六个)基因可以被中断。
“中断”是指突变改变了基因的编码序列，使得功能性基因产物如蛋白质不再产生。本文可以使用术语“中断”来指代中断基因的突变。突变应以破坏基因的表达和/或活性的方式中断编码序列，即不再从基因产生功能性基因产物如蛋白质。
中断可以完全消除基因产物的产生。例如，在基因产物是蛋白质的情况下，中断可以使mRNA变得无意义，导致mRNA被降解而蛋白质不翻译，从而消除了蛋白质的产生。中断可以改变产生的基因产物。中断可以导致基因不转录和/或翻译。
中断可以是点突变(即单个核苷酸的取代、插入或缺失)。中断可以是缺失。基因可以包含导致基因中断的多个突变。
中断可以是移码突变。移码导致移码下游的密码子被读为不同的氨基酸。产生的蛋白质可以是非功能性的。
中断可以是起始密码子的突变。起始密码子通常是ATG。起始密码子的突变(例如，一个、两个或三个核苷酸的点突变)意味着翻译不会从该密码子开始。翻译可以在更下游的后续起始密码子处开始。如果后续的起始密码子在框内，则产生的蛋白质形式是N端截短的，因此可能是无功能的。如果后续的起始密码子不在框内，则会产生完全不同的或无义的蛋白质，其将是无功能的。如果没有后续的起始密码子，则翻译完全被消除，不会产生蛋白质。
中断可以是终止密码子(TAG、TAA或TGA)的突变。终止密码子的突变(也称为非终止突变)导致mRNA继续翻译成不应翻译的序列。由于其长度过长，所得蛋白可能是非功能的。
突变组合
可以将本文所述的破坏基因表达和/或活性的突变组合在本发明的减毒ASFV中。换言之，本发明的减毒ASFV中的每个被破坏的基因(MGF 360基因12L、13L和14L，MGF 505基因1R)可以通过与任何其他基因相同类型的突变或通过与任何其他基因不同类型的突变被破坏。
在本发明的减毒ASFV的实施方案中，一个或多个被破坏的基因可以通过启动子序列的突变而被破坏，而一个或多个其他被破坏的基因可以通过编码序列的部分缺失而被破坏，而一个或多个其他基因可以通过编码序列的完全缺失而被破坏，而一个或多个其他基因可以通过基因的中断而被破坏。
疫苗/药物组合物
本发明还提供了包含本发明的减毒ASF病毒的疫苗。
如本文所用，术语“疫苗”是指当施用于受试者时诱导或刺激保护性免疫应答的制剂。疫苗可以使生物体对特定疾病(在本例中为ASF)免疫。因此，本发明的疫苗在受试者中诱导免疫应答，该免疫应答对随后的ASF病毒攻击具有保护性。包含本发明的减毒ASFV的疫苗可以能够诱导针对多种ASF病毒基因型的交叉保护性免疫应答。在实施方案中，包含单一基因型的本发明的减毒ASFV的疫苗可以能够诱导针对多种ASF病毒基因型的交叉保护性免疫应答。
疫苗可以包含多种减毒ASF病毒。多种减毒ASF病毒可以对应于多种不同的分离株，例如高毒力或未知毒力的不同分离株。这样的疫苗可以能够诱导针对多种ASF病毒基因型的交叉保护性免疫应答。
疫苗可以用于预防非洲猪瘟。因此本发明提供了用于治疗和/或预防受试者的非洲猪瘟的本发明的疫苗。
本发明还提供了包含一种或多种本发明的减毒ASF病毒的药物组合物。该药物组合物可用于治疗非洲猪瘟。
疫苗或药物组合物可以包含一种或多种本发明的减毒ASF病毒和任选的一种或多种佐剂、赋形剂、载剂和稀释剂。药用赋形剂、载剂或稀释剂的选择可以根据预期的施用途径和标准药学实践来选择。药物组合物可以包含作为载剂、赋形剂或稀释剂(或除此之外)的任何合适的粘合剂、润滑剂、助悬剂、包衣剂、增溶剂和其他载剂。药物组合物通常在制造和储存条件下应该是无菌和稳定的。用于肠胃外施用的制剂包括但不限于混悬剂、溶液、油性或水性载体中的乳剂、糊剂和可植入的缓释或生物降解制剂。可以使用无毒的肠胃外可接受的稀释剂或溶剂来制备无菌可注射制剂。本发明的药物组合物可以包括药学上可接受的分散剂、润湿剂、悬浮剂、等渗剂、包衣剂、抗菌剂和抗真菌剂、载剂、赋形剂、盐或稳定剂，它们在所采用的剂量和浓度下对受试者是无毒的。优选地，这样的组合物可以进一步包含药学上可接受的载剂或赋形剂，用于治疗与给定方法和/或施用部位(例如对于肠胃外(例如皮下、皮内或静脉内注射)或鞘内施用)相容的疾病。
疫苗或药物组合物可以包含有效量的一种或多种本发明的减毒ASF病毒。
在实施方案中，本发明提供了本发明的减毒ASF病毒，其在施用于受试者时诱导免疫应答，该免疫应答对随后的强毒ASF病毒攻击具有保护性。在实施方案中，本发明提供了本发明的减毒ASF病毒，其在施用于受试者时诱导免疫应答，该免疫反应对随后用与疫苗的减毒ASF病毒不同基因型的强毒ASF病毒攻击具有保护性。
预防/治疗方法
本发明还提供了通过向受试者施用有效量的本发明的减毒病毒、疫苗或药物组合物来预防和/或治疗受试者中的ASF的方法。
术语“预防”旨在指避免、延迟、阻止或阻碍ASF的感染。疫苗可以例如预防或降低感染性ASFV进入细胞的可能性。
术语“治疗”旨在指减少或减轻现有ASF感染的至少一种症状。
受试者可以是易受ASF感染的任何动物。ASF易感动物包括家猪、疣猪、丛林猪和蜱。
根据本发明的疫苗接种对象可以是家猪。
施用
本发明的疫苗可以通过任何方便的途径施用，如通过肌内注射。其他合适的施用途径包括鼻内、经口、皮下、透皮和阴道(例如在人工授精期间)。在一个实施方案中，口服施用包括将疫苗添加到动物饲料或饮用水中。在另一个实施方案中，可以将疫苗添加到野生动物的诱饵中，例如适用于山猪、野猪、丛林猪或疣猪的诱饵。
猪免疫的剂量可以低于每头猪104HAD50或TCID50。例如，剂量可以在102-103HAD50或TCID50之间。剂量可以是每头猪约102HAD50或TCID50。剂量可以由兽医在合理的兽医判断范围内确定。
疫苗可以遵循初免加强方案施用。例如，在第一次接种后，受试者可以在一段时间(如约7、14、21或28天)后接受第二次加强施用。通常，加强施用的剂量高于初次施用。加强剂量可以是每头猪约102、103或104HAD50或TCID50重组减毒病毒。
减毒病毒的制备方法
本发明还进一步提供了使ASF病毒减毒的方法，该方法包括破坏以下基因的表达和/或活性的步骤：
MGF 360基因12L、13L和14L；以及
MGF 505基因1R，
同时保留以下基因的功能：
(i)MGF 360 10L和/或11L，以及
(ii)MGF 505 2R和/或3R。
基因表达和/或活性的破坏可以通过以本文所述的任何方式使ASFV基因组突变来实现。
以下基因可以部分或完全缺失：
MGF 360基因12L、13L和14L；以及
MGF 505基因1R。
一个或多个(如两个或多个、三个或多个或所有四个)被破坏的基因可以至少部分或完全缺失。一个或多个(如两个或多个、三个或多个或所有四个)被破坏的基因的编码序列可以至少部分或完全缺失。
以下基因可以被中断：
MGF 360基因12L、13L和14L；以及
MGF 505基因1R。
一个或多个(如两个或多个、三个或多个或所有四个)基因可以被中断。
用于病毒基因突变的方法是本领域已知的。具体而言，用于缺失病毒基因的方法是本领域已知的。例如，可以使用同源重组，其中产生相关基因缺失的转移载体并用于转染病毒感染的细胞。然后可以选择表达新序列部分的重组病毒。可以使用类似的程序来中断基因表达，例如通过缺失ATG起始密码子。
“保留基因的功能”是指基因的表达和活性在减毒过程中不受影响。产生的减毒病毒应表达基因的功能形式。适当地，功能将被保留的基因没有被减毒方法改变。适当地，功能将被保留的基因的序列没有被减毒方法改变。
在本发明的一些实施方案中，使ASF病毒减毒的方法可以包括保留MGF 360 10L和MGF 505 2R的功能。在一些实施方案中，该方法可以包括保留MGF 360 11L以及MGF 505 2R的功能。在一些实施方案中，该方法可以包括保留MGF 360 10L以及MGF 505 3R的功能。在一些实施方案中，该方法可以包括保留MGF 360 11L以及MGF 505 3R的功能。在一些实施方案中，该方法可以包括保留MGF 360 10L和11L以及MGF 505 2R的功能。在一些实施方案中，该方法可以包括保留MGF 360 10L和11L以及MGF 505 3R的功能。在一些实施方案中，该方法可以包括保留MGF 360 10L以及MGF 505 2R和3R的功能。在一些实施方案中，该方法可以包括保留MGF 360 11L以及MGF 505 2R和3R的功能。在一些实施方案中，该方法可以包括保留MGF 360 10L和11L以及MGF 505 2R和3R的功能。
本公开不受本文公开的示例性方法和材料的限制，并且与本文所述的那些相似或等效的任何方法和材料都可以用于本公开的实施方案的实践或测试。数字范围包括限定范围的数字。除非另有说明，否则任何核酸序列均以5'至3'方向从左到右书写；氨基酸序列分别以氨基到羧基的方向从左到右书写。
必须注意，如本文和所附权利要求中使用的，单数形式“一个”、“一种”和“该”包括复数指示，除非上下文另有明确规定。
如本发明所用的术语“包含”,“包括”和“含有”与“包括”、“包含”或者“包括”、“包含”同义,并且是包容性或开放式的，并且不排除额外的、未列举的成员、元素或方法步骤。术语“包括”、“包含”和“含有”还包括术语“由...组成”。
本文所讨论的出版物仅针对其在本申请的提交日期之前的公开而提供。本文中的任何内容均不应被解释为承认此类出版物构成所附权利要求的现有技术。
现将通过实施例进一步描述本发明，这些实施例旨在帮助本领域的普通技术人员实施本发明并且不以任何方式限制本发明的范围。
实施例
实施例1–MGF基因抑制转录因子IRF3和NF-κB的活性
使用萤光素酶报告基因测定法测试了MGF基因对干扰素调节因子3(IRF3)和NF-κB活性的影响。IRF-3和NF-κB是控制作为宿主先天免疫系统对病毒感染的应答的一部分的干扰素和促炎细胞因子的表达的转录因子。
HEK293T细胞用在IRF3特异性激活的启动子控制下的萤光素酶报告基因转染。细胞还用表达MGF基因(MGF360-10L、11L、12L、13L或14L、MGF 505-1R、2R、3R、4R或5R，或MGF110-1L)的质粒、空载体(作为阴性对照)或表达CSFV Npro(已知的IRF3抑制蛋白，作为阳性对照)的质粒转染。然后用仙台病毒(SeV)刺激细胞以活化IRF3。刺激后萤光素酶的水平提供了MGF调节通过IRF-3和NF-kB控制的信号传导级联的能力的量度。如图1A所示，用SeV刺激后的萤光素酶表达水平在用空载体转染的细胞中高，但在用IRF3抑制剂或任何MGF基因转染的细胞中低。因此，这些数据表明，所有测试的MGF基因都抑制IRF3活性。
进行了等效的实验来测试MGF基因对NF-κB表达的影响。在该实验中，细胞用在NF-κB特异性激活的启动子控制下的萤光素酶报告基因转染，抑制NF-κB的痘病毒MC160蛋白用作阳性对照，NF-κB通过具有NF-κB亚基p65的细胞的转染被激活。图1B所示的结果表明，测试的所有MGF基因都抑制NF-κB活性。
MGF360-12L抑制IRF3和NF-κB的转录活性
进行了进一步的实验以进一步研究MGF基因如何抑制IRF3和NF-κB活性。
转录因子(TF)通常具有两个主要结构域：转录激活结构域(TAD)和DNA结合结构域(DBD)。这些结构域是可互换的，因此含有来自不同TF的TAD和DBD的嵌合蛋白可用于进一步探究细胞信号传导通路。
含有NF-κB p65或与GAL4 DBD融合的IRF3 TAD的嵌合体用于评估MGF直接抑制NF-κB p65或IRF3转录活性的能力。在这种情况下，报告质粒含有在由GAL4 DBD识别的响应元件控制下的萤光素酶基因。因此，萤光素酶活性不依赖于IRF3或NF-KB结合其启动子的能力，而仅依赖于它们的激活状态。
图1C和图1D分别显示MGF360-12L抑制由IRF-3(TAD)-GAL4(DBD)和p65(TAD)-GAL4(DBD)的过表达诱导的萤光素酶活性。相比之下，MGF家族的其他成员在该测定中不抑制萤光素酶活性。
总之，这些结果表明，所有测试的MGF基因都能够通过与DNA结合和/或募集共激活因子来抑制IRF-3和NF-kB功能。MGF 360-12L还直接抑制这些转录因子的活性，因此为与其他MGF基因相比，使用MGF 360-12L观察到的IRF3和NF-kB的更强抑制提供了可能的解释。NF-kB启动子结合元件存在于除I型干扰素之外的其他基因的启动子中，该通路的抑制可能会影响更广泛的基因，包括那些参与激活促炎反应的基因。
实施例2–MGFA与K145R或B125R的缺失使ASFV减毒并诱导针对攻击的保护
MGFA和MGFB缺失
多基因家族360和505的两组基因在ASFV格鲁吉亚2007/1株中缺失。
在MGFA中，基因MGF360-12L、MGF360-13L、MGF360-14L和MGF505-1R的完整编码区缺失。
在MGFB中，基因MGF360-13L、MGF360-14L、MGF505-2R和MGF505-3R的完整编码区缺失。
MGFA和MGFB缺失在图2中示意性显示。在每个基因名称下方，总结了IRF3和NF-κB依赖性萤光素酶报告基因的抑制信息，并列出了任何已确定的宿主靶标。
将MGFA缺失与K145R基因(格鲁吉亚ΔK145RΔMGFA)或B125R基因(格鲁吉亚ΔB125RΔMGFA)的缺失组合。
MGFB缺失与K145R基因(格鲁吉亚ΔK145RΔMGFB)的缺失组合。
疫苗接种实验方案
用104TCID50/ml格鲁吉亚ΔK145RΔMGFA(C组)、格鲁吉亚ΔK145RΔMGFB(D组)或格鲁吉亚ΔB125RΔMGFA(BA组)病毒对每组6头大白长白猪进行肌内免疫。
D组的猪在免疫后在人道终点淘汰。
对C组和BA组中的猪进行加强免疫，然后用亲本强毒格鲁吉亚毒株攻击。
实验方案如图3所示。
存活率
来自D组(格鲁吉亚ΔK152RΔMGFB)的猪均在免疫后第5天至第9天在中等严重程度终点淘汰(图4A)。
来自C组(格鲁吉亚ΔK145RΔMGFA)和BA组(格鲁吉亚ΔB125RΔMGFA)的猪在免疫和加强免疫后存活。
攻击后，来自C组的2头猪在攻击后第7天或第11天(图4A)淘汰，而BA组的3头猪在攻击后6至8天在中等严重程度终点淘汰(图4B)。其余的猪一直存活到实验结束。如所预期的，对照非免疫猪(F组)在攻击后第6天淘汰(图4A和图4B)。因此存活率为66％。
体温和临床评分
C组和BA组中的猪在免疫和加强免疫后没有出现体温升高(图5A和图5B)或临床症状增加(图6A和图6B)。
在攻击后第5天或第6天，所有猪(除了来自C组的一头猪)出现超过40.5℃的温度和持续1至3天的其他症状(除了在中等严重程度终点淘汰的猪)。其余的猪没有表现出进一步的症状，直至实验终止。
病毒血症
在整个实验过程中，通过定量PCR测量全血中病毒基因组的水平。C组中免疫的一头猪在免疫后第6天具有非常低的基因组水平，但C组或AB组中的其他猪在免疫或加强免疫后没有可检测的病毒基因组(图7A和图7B)。相比之下，D组中的所有猪在免疫后第6天都具有高水平的病毒基因组，如由临床症状所预期的(图7C)。
攻击后，在所有猪的血液中检测到病毒基因组。在C组中，攻击后第7天在所有存活的猪中检测到在10e4至10e6基因组拷贝数/ml之间变化的峰值，并且在此之后缓慢下降。如所预期的，在两头未存活的猪中检测到更高水平的病毒基因组。在BA组中，在存活的猪中检测到相似水平的病毒基因组，而在未存活的猪中检测到更高水平的病毒基因组。
血液中的感染性病毒
攻击后测量全血中感染性病毒的水平(图8)。
T细胞应答
在免疫前、加强前和攻击前收集外周血单核细胞(PBMC)，并用活ASFV(同源强毒格鲁吉亚2007/1株或异源基因型I强毒株贝宁97/1)刺激。通过Elispot测定法测量产生干扰素γ的细胞的数量(图9)。
如所预期的，在免疫前没有检测到应答。在C组中，在加强前检测到对格鲁吉亚病毒刺激的低应答，但在攻击前这些应答增加了数倍(图9A)。除了一头猪外，对强毒贝宁的应答如所预期的那样低(图9B)。在AB组中，在加强之前观察到更高水平的产生IFNγ的细胞，但在攻击之前该水平并未增加(图9C和图9D)。
抗体应答
免疫后使用商业竞争性ELISA(Ingenasa)测量对主要ASFV衣壳蛋白p72/B646L的抗体应答。免疫后第30天(加强免疫后)在C组的猪中检测到高于截止值的抗体应答，此后增加，但直到攻击后才达到100％(图10A)。在BA组的猪中观察到了类似的结果，但在免疫后第20天首次检测到抗体应答(图10B)。
实施例4-DIVA靶标的筛选
为了在ASFV中筛选可作为区分感染和免疫动物(DIVA)标记物的基因，将编码与HA或V5表位标签融合的单独ASFV基因(不包括已知的必需基因)的71个质粒转染到Vero细胞中。将细胞固定、透化并用来自不同免疫猪的抗血清染色，然后用荧光标记的二抗染色。共聚焦显微镜用于评估是否可以检测到表达的基因。
同时，细胞用抗与ASFV基因融合的HA或V5标签的抗体和不同的荧光标记二抗染色，以确认蛋白质的表达。
用于对细胞进行染色的猪血清来自使用以下病毒的免疫研究：贝宁ΔDP148R(5头猪)、贝宁ΔMGF(6头猪)、OURT88/3(5头猪)和格鲁吉亚ΔMGF(4头猪)。对于每头猪，使用免疫前血清样品(作为对照)和免疫后攻击前血清样品。
使用来自贝宁ΔDP148R免疫猪的血清(第0天的免疫前血清，免疫后第38天的免疫后血清)进行基因的初步筛选。ASFV基因CP204L、B646L和E183L用作阳性对照，并使用免疫后血清进行检测。免疫前血清未检测到任何基因。
使用贝宁ΔDP148R免疫后血清检测到六个ASFV基因，如下表5所示(++表示强检测，+表示弱检测，-表示未检测)。
表5
然后用来自其他免疫研究的猪血清测试在初始筛选中检测到的六个ASFV基因。
下表6显示了使用来自贝宁ΔMGF病毒免疫的6头猪的免疫后血清的ASFV基因检测(在第15天加强，在免疫后第38天采集免疫后血清；免疫前血清为阴性)。
表6
下表7显示了使用来自OURT88/3病毒免疫的5头猪的免疫后血清的ASFV基因检测(在免疫后第20天采集免疫后血清；免疫前血清除猪2外均为阴性)。
表7
下表8显示了使用来自格鲁吉亚ΔMGF病毒免疫的4头猪的免疫后血清的ASFV基因检测(在免疫后第34天采集免疫后血清；在第-3天采集的免疫前血清为阴性)。2头猪(A)用103格鲁吉亚ΔMGF免疫；2头猪(B)用104格鲁吉亚ΔMGF免疫。
表8
实施例5–B125R在细胞表面的定位
用表达与HA表位标签融合的B125R基因的质粒转染Vero细胞。将细胞固定并透化，然后用抗HA抗体和随后的适当的二抗染色。图11显示B125R蛋白(绿色)定位于细胞表面。
以上说明书中提到的所有出版物通过引用并入本文。在不脱离本发明的范围和精神的情况下，本发明的所述方法和系统的各种修改和变化对于本领域技术人员将是显而易见的。尽管已经结合具体的优选实施方案描述了本发明，但应理解，要求保护的本发明不应过度限于这些具体的实施方案。实际上，对病毒学、分子生物学或相关领域的技术人员显而易见的用于实施本发明的所述模式的各种修改旨在落入所附权利要求的范围内。
序列表
<110> 皮尔布莱特研究所
<120> 抗非洲猪瘟病毒感染的疫苗
<130> P119014PCT
<150> GB 2003289.2
<151> 2020-03-06
<150> GB 2005880.6
<151> 2020-04-22
<160> 207
<170> PatentIn 版本 3.5
<210> 1
<211> 345
<212> PRT
<213> 非洲猪瘟病毒
<400> 1
Met Phe Pro Ser Leu Gln Ser Phe Ala Lys Lys Val Leu Ala Arg Gln
1 5 10 15
Gln Val Ser Ile Glu Tyr His Val Ile Leu Glu Arg Cys Gly Leu Trp
20 25 30
Trp Tyr Lys Ala Pro Ile Ser Leu Asp Cys Lys His Met Leu Ile Lys
35 40 45
Leu Pro Ser Phe Ala Asp Gly Leu Asp Leu Asn Thr Ala Leu Met Leu
50 55 60
Ala Thr Lys Glu Asn Asn Tyr Gln Leu Ile Lys Leu Phe Thr Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Ile Cys Ala Asn Thr Pro Pro Val
85 90 95
Arg Glu Phe Cys Trp Glu Leu Gly Ala Lys Tyr Arg Val Asp Lys Lys
100 105 110
Lys Ile Met His Met Phe Phe Lys Leu Ile His Pro Gly Thr Thr Ser
115 120 125
Ser Asn Ile Ile Leu Cys Leu Lys Leu Phe Asn Asp Asn Pro Phe Pro
130 135 140
Ala Tyr Val Ile Ile Arg Glu Ile Arg Ser Ser Ile Tyr Trp Lys Leu
145 150 155 160
Lys Arg Leu Val Glu Asp Thr Asp Ile Leu Ser Asn Met Ser Asp Gly
165 170 175
Asp Met Leu Thr Ile Tyr Cys Phe Ile Val Ala Leu Gln Asp Asn Leu
180 185 190
Arg Glu Ala Ile Ser Tyr Val Tyr Gln His Phe Lys Tyr Leu Asn Thr
195 200 205
Trp Trp Leu Ile Cys Ala Leu Cys Phe Asn Lys Leu Phe Asp Leu His
210 215 220
Asn Leu Tyr Glu Lys Glu Lys Ile Arg Met Asp Val Asp Glu Met Met
225 230 235 240
Arg Met Ala Cys Thr Lys Asp Asn Asn Phe Leu Thr Ile Tyr Tyr Cys
245 250 255
Phe Leu Leu Gly Ala Asn Ile Asn Ser Ala Met Leu Ala Cys Val Arg
260 265 270
Phe Tyr Asn Met Asp Asn Leu Phe Phe Cys Ile Asp Leu Gly Ala Asp
275 280 285
Ala Phe Glu Glu Ala Lys Ala Leu Ala Glu Gln Arg Asn Tyr Tyr Leu
290 295 300
Ile Ser His His Leu Ser Leu Asp Ile Tyr Ser Ala Asp Ser Ser Leu
305 310 315 320
Leu Thr Leu Lys Glu Ala Asp Pro Asn Lys Ile Tyr His Leu Leu Lys
325 330 335
Asn Tyr Lys Leu Lys Ser Met Leu Ala
340 345
<210> 2
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 2
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Ile Pro Val Asp Gln Tyr His Val Leu Lys Cys Cys Gly Leu Trp
20 25 30
Trp His Asn Gly Pro Ile Met Leu His Ile Arg Arg Asn Lys Leu Phe
35 40 45
Ile Arg Ser Thr Cys Phe Ser Gln Gly Ile Glu Leu Asn Ile Gly Leu
50 55 60
Met Lys Ala Val Lys Glu Asn Asn His Asp Leu Ile Lys Leu Phe Thr
65 70 75 80
Glu Trp Gly Ala Asp Ile Asn Tyr Gly Met Ile Cys Ala Leu Thr Glu
85 90 95
Asn Thr Arg Asp Leu Cys Lys Glu Leu Gly Ala Lys Glu Tyr Leu Glu
100 105 110
Arg Glu Tyr Ile Leu Lys Ile Phe Phe Asp Thr Thr Arg Asp Lys Thr
115 120 125
Ser Ser Asn Ile Ile Phe Cys His Glu Val Phe Ser Asn Asn Pro Asn
130 135 140
Leu Arg Ile Ile Asp Asn Leu Asp Leu Arg Gly Glu Ile Met Trp Glu
145 150 155 160
Leu Arg Gly Leu Met Glu Ile Thr Phe Met Leu Asp His Asp Asp Ser
165 170 175
Phe Ser Thr Val Leu Thr Lys Tyr Trp Tyr Ala Ile Ala Val Asp Tyr
180 185 190
Asp Leu Lys Asp Ala Ile Arg Tyr Phe Tyr Gln Lys Tyr Pro Arg Leu
195 200 205
His Arg Trp Arg Leu Met Cys Ala Leu Phe Tyr Asn Asn Val Phe Asp
210 215 220
Leu His Glu Leu Tyr Glu Ile Glu Arg Val Arg Met Asp Ile Asp Glu
225 230 235 240
Met Met His Ile Ala Cys Ile Gln Asp Tyr Ser Tyr Ser Ala Ile Tyr
245 250 255
Tyr Cys Phe Ile Met Gly Ala Asn Ile Asn Gln Ala Met Leu Val Ser
260 265 270
Ile Gln Asn Tyr Asn Leu Gly Asn Leu Phe Phe Cys Ile Asp Leu Gly
275 280 285
Ala Asp Ala Phe Glu Glu Gly Lys Ala Leu Ala Glu Gln Lys Glu Asn
290 295 300
Tyr Leu Ile Ala His Ala Leu Ser Leu Lys His Tyr Asn Pro Val Ile
305 310 315 320
Ser Leu Leu Ser Ile Val Thr Asp Pro Glu Lys Ile Asn Cys Met Leu
325 330 335
Lys Asn Tyr His Ser Ile Asn Met Gly Ile Phe Leu Asp Tyr Glu Gln
340 345 350
Arg
<210> 3
<211> 350
<212> PRT
<213> 非洲猪瘟病毒
<400> 3
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asn Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Val Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Ser Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 4
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 4
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Ile Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Cys Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Arg Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Gly Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Arg Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Ile Leu Glu Asn Lys Phe Val Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Gly Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Asp Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Glu Asn Ile Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Ala Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 5
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 5
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Val Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Tyr Leu Lys Arg Leu Cys Ala Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Arg Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His His Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys His Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Ala Asp Phe Asp
275 280 285
Arg Ala Gln Leu Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Val Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 6
<211> 531
<212> PRT
<213> 非洲猪瘟病毒
<400> 6
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asn Arg Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Thr Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Gln Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys His Arg Leu Glu Asp Asp Leu
145 150 155 160
Pro Phe Thr His Leu Leu Ile Glu Lys Ala Cys Lys Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asn Met Ile
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu His Leu Tyr Cys
195 200 205
Leu Gly Tyr Arg Phe Ile Tyr Asn Arg Ile Val Pro Asp Lys Tyr His
210 215 220
His Leu Asp Ile Arg Met Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Lys Asp Asn Ile Asn Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Ile Tyr Phe Ile Pro Gln Ser Thr His Ala
275 280 285
Gln Ile Glu Gln Cys Leu Leu Val Ala Ile Lys Ala Lys Ser Ser Arg
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Asn Leu
305 310 315 320
Ile Lys Lys Ile Ser His Tyr Val Ala Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Arg Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Lys Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Leu Lys Ile
370 375 380
Ala Ala Arg Ile Asn Arg Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Val Arg Leu Lys Tyr Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp Arg Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Val Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys Gln
515 520 525
Tyr Met Pro
530
<210> 7
<211> 526
<212> PRT
<213> 非洲猪瘟病毒
<400> 7
Met Phe Ser Leu Gln Asp Leu Cys Arg Lys His Leu Phe Ile Leu Pro
1 5 10 15
Asp Val Phe Gly Glu His Val Leu Gln Arg Leu Gly Leu Tyr Trp Arg
20 25 30
Cys His Gly Ser Leu Gln Arg Ile Gly Asp Asp His Ile Leu Ile Arg
35 40 45
Arg Asp Leu Ile Leu Ser Thr Asn Glu Ala Leu Arg Met Ala Gly Glu
50 55 60
Glu Gly Asn Asn Glu Val Val Lys Leu Leu Leu Leu Trp Lys Gly Asn
65 70 75 80
Leu His Tyr Ala Val Ile Gly Ala Leu Gln Gly Asp Gln Tyr Asp Leu
85 90 95
Ile His Lys Tyr Glu Asn Gln Ile Gly Asp Phe His Phe Ile Leu Pro
100 105 110
Leu Ile Gln Asp Ala Asn Thr Phe Glu Lys Cys His Ala Leu Glu Arg
115 120 125
Phe Cys Gly Val Ser Cys Leu Leu Lys His Ala Thr Lys Tyr Asn Met
130 135 140
Leu Pro Ile Leu Gln Lys Tyr Gln Glu Glu Leu Ser Met Arg Ala Tyr
145 150 155 160
Leu His Glu Thr Leu Phe Glu Leu Ala Cys Leu Trp Gln Arg Tyr Asp
165 170 175
Val Leu Lys Trp Ile Glu Gln Thr Ile His Val Tyr Asp Leu Lys Ile
180 185 190
Met Phe Asn Ile Ala Ile Ser Lys Arg Asp Leu Thr Met Tyr Ser Leu
195 200 205
Gly Tyr Ile Phe Leu Phe Asp Arg Gly Asn Thr Glu Ala Thr Leu Leu
210 215 220
Thr Gln His Leu Lys Lys Thr Ala Ala Lys Gly Leu Leu His Phe Val
225 230 235 240
Leu Glu Thr Leu Lys Tyr Gly Gly Asn Ile Asp Thr Val Leu Thr Gln
245 250 255
Ala Val Lys Tyr Asn His Arg Lys Leu Leu Asp Tyr Phe Leu Arg Gln
260 265 270
Leu Pro Arg Lys His Ile Glu Lys Leu Leu Leu Leu Ala Val Gln Glu
275 280 285
Lys Ala Ser Lys Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Tyr
290 295 300
Ser Val Lys Arg Ile Lys Lys Leu Pro Arg Tyr Val Ile Glu Tyr Glu
305 310 315 320
Ser Thr Leu Val Ile Lys Ile Leu Leu Lys Lys Arg Val Asn Leu Ile
325 330 335
Asp Ala Met Leu Glu Lys Met Val Arg Tyr Phe Ser Ala Thr Lys Val
340 345 350
Arg Thr Ile Met Asp Glu Leu Ser Ile Ser Pro Glu Arg Val Ile Lys
355 360 365
Met Ala Ile Gln Lys Met Arg Thr Asp Ile Val Ile His Thr Ser Tyr
370 375 380
Val Trp Glu Asp Asp Leu Glu Arg Leu Thr Arg Leu Lys Asn Met Val
385 390 395 400
Tyr Thr Ile Lys Tyr Glu His Gly Lys Lys Met Leu Ile Lys Val Met
405 410 415
His Gly Ile Tyr Lys Asn Leu Leu Tyr Gly Glu Arg Glu Lys Val Met
420 425 430
Phe Tyr Leu Ala Lys Leu Tyr Val Ala Gln Asn Ala Ala Thr Gln Phe
435 440 445
Arg Asp Ile Cys Lys Asp Cys Tyr Lys Leu Asp Val Ala Arg Phe Lys
450 455 460
Pro Arg Phe Lys Gln Leu Ile Leu Asp Cys Leu Glu Ile Ile Thr Lys
465 470 475 480
Lys Ser Cys Tyr Ser Ile Leu Glu Ile Leu Glu Lys His Ile Ile Ser
485 490 495
Leu Phe Thr Met Lys Val Met Thr Glu Glu Glu Lys Asn Leu Cys Leu
500 505 510
Glu Ile Leu Tyr Lys Val Ile His Tyr Lys Thr Ile Gln Cys
515 520 525
<210> 8
<211> 280
<212> PRT
<213> 非洲猪瘟病毒
<400> 8
Met Ser Ser Ser Leu Gln Glu Leu Cys Arg Lys Lys Leu Pro Asp Cys
1 5 10 15
Ile Leu Pro Glu Phe Phe Asp Asp Tyr Val Leu Gln Leu Leu Gly Leu
20 25 30
His Trp Gln Asp His Gly Ser Leu Gln Arg Ile Glu Lys Asn Gln Ile
35 40 45
Leu Val Gln Gln Glu Pro Ile His Ile Asn Glu Ala Leu Lys Val Ala
50 55 60
Ala Ser Glu Gly Asn Tyr Glu Ile Val Glu Leu Leu Leu Ser Trp Glu
65 70 75 80
Ala Asp Pro Arg Tyr Ala Val Val Gly Ala Leu Glu Ser Lys Tyr Tyr
85 90 95
Asp Leu Val Tyr Lys Tyr Tyr Asp Gln Val Lys Asp Cys His Asp Ile
100 105 110
Leu Pro Leu Ile Gln Asn Pro Glu Thr Phe Glu Arg Cys His Glu Leu
115 120 125
Asn Ser Thr Cys Ser Leu Lys Cys Leu Phe Lys His Ala Val Ile Asn
130 135 140
Asp Met Leu Pro Ile Leu Gln Lys Tyr Thr Asp Tyr Leu Asp Arg Trp
145 150 155 160
Glu Tyr Cys Ser Gln Met Leu Phe Glu Leu Ala Cys Ser Lys Lys Lys
165 170 175
Tyr Glu Met Val Val Trp Ile Glu Gly Val Leu Gly Val Gly Lys Val
180 185 190
Thr Ser Leu Phe Thr Ile Ala Ile Ser Asn Arg Asp Leu Gln Leu Tyr
195 200 205
Ser Leu Gly Tyr Ser Ile Ile Leu Glu Asn Leu Tyr Ser Cys Gly Gln
210 215 220
Asp Pro Lys Phe Leu Leu Asn His Phe Leu Arg Asp Val Ser Ile Lys
225 230 235 240
Gly Leu Leu Pro Phe Val Ile Lys Thr Ile Glu Tyr Gly Gly Ser Lys
245 250 255
Glu Ile Ala Ile Thr Leu Ala Lys Lys Tyr Gln His Lys His Ile Leu
260 265 270
Lys Tyr Phe Glu Thr Trp Glu Ser
275 280
<210> 9
<211> 145
<212> PRT
<213> 非洲猪瘟病毒
<400> 9
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 10
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 10
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 11
<211> 1071
<212> DNA
<213> 非洲猪瘟病毒
<400> 11
ttataacgat gtatcattga tgtcataatt caaataggcc aacatacttt ttgatttata 60
gttttttaat agacgatata ttttgttagg atctgcttct tttaacgtta atagcgagga 120
gtctggacta taaatgtcta atgataaacg atgagatatc aaatagtaat tctgttgctc 180
tgccaaggct tttgcctctt caaaggcatc ggcccccaga tctatacaaa agaacaggtt 240
atccatatta tagaatcgta tggaggcaat catggccaaa ttaatattag ctcctaagat 300
aaaacaataa tatatagtta aaaaattgtt atcttttgtg caggctatcc gcatcatttc 360
atccatgtcc atacggattt tttctttttc gtacaaatta tgtaggtcaa acagcttatt 420
atagcaaaga gcacatgtta accaccacgt attcagatac ttaaaatgtt ggtaaacata 480
agaaatggcc tccctaagat tatcctgcaa tgccacgata aaacagtata tagttaacat 540
atcaccatcc gaaatattac ttaatacgtt ggtatcttct gctaaatttt ttagcttcca 600
atgtatacac gactttattt cccttataat gacataggct gaaaagggat tgtcattaaa 660
aaatttaaga cataagataa tattattact agtagtgtta ggatgtatta atttaaagaa 720
tatgtgcata atcttctttt tatccacttg gtacttggct cctaattccc agcaaaattc 780
tcgaataggt ggcgtattcg cgcaaattaa cccatagttg atgtctgcgc cccaatccgt 840
aaacattttt attaattgat agttgttttc ctttgtagcc aacattagtg ccgtattaag 900
gtccaagcca tctgcaaagt ttggcagctt tatcagcata tgtttgcaat caagtgaaat 960
tggagcctta taccaccata gcccgcagcg ttctaagata acatggtaat caatagatac 1020
atgctgactg gctaatacct ttttggcgaa ggattgcaag gaaggaacca t 1071
<210> 12
<211> 1038
<212> DNA
<213> 非洲猪瘟病毒
<400> 12
ctaggccaac atacttttta atttatagtt ttttaataga tgatatattt tgctaggatc 60
tgcttctttt aacgttaata gcgaggagtc tgcactataa atgtctaatg ataaatgatg 120
agatatcaaa tagtaattcc gttgctctgc tagggccttt gcctcttcaa aggcgtcggc 180
tcccagatct atacaaaaga acaagttatc catattataa aatcgtacgc aggcaagcat 240
agctgaatta atattagctc ctaagagaaa acaataatat atggttaaaa aattgttatc 300
ttttgtgcag gccatccgca tcatttcatc cacgtccatg cggatctttt ccttttcata 360
caaattatgt aggtcaaaca gcttattaaa acaaagagca cagattaacc accacgtatt 420
tagatactta aaatgttggt aaacataaga aatggcctcc ctaagattat cctgcaatgc 480
cactataaaa cagtatatcg ttaacatatc accatccgac atattactta atatgtcggt 540
gtcttctact aaccttttca acttccaata tatggatgac cttatttccc ttataatgac 600
ataggctgga aagggattat cattaaaaag tttaagacat aagataatat tactgctagt 660
agtgccaggg tgtattaatt taaagaacat gtgcataatc ttctttttat ccacgcggta 720
cttggctcct aattcccagc aaaattctcg aacaggcggc gtattggcgc aaattaaccc 780
atagttgatg tctgcgcccc attctgtaaa cagttttatt aactgatagt tgttttcctt 840
tgtagccaac attagtgccg tattaaggtc caagccgtct gcaaagcttg gcagctttat 900
cagcatatgt ttgcaatcaa gggaaattgg ggccttatac caccatagtc cgcagcgttc 960
taagataaca tggtactcaa tagatacttg ctgtctggct agtacctttt tggcgaagga 1020
ttgtaaggaa ggaaacat 1038
<210> 13
<211> 1038
<212> DNA
<213> 非洲猪瘟病毒
<400> 13
ctaggccaac atacttttta atttatagtt ttttaataga tgatatattt tgttaggatc 60
tgcttctttt aacgttaata gcgaggagtc tgcactataa atgtctaatg ataaatgatg 120
agatatcaaa tagtaattcc gttgctctgc tagggccttt gcctcttcaa aggcgtcggc 180
tcccagatct atacaaaaga acaagttatc catattataa aatcgtacgc aggcaagcat 240
agctgaatta atattagctc ctaagagaaa acaataatat atggttaaaa aattgttatc 300
ttttgtgcag gccatccgca tcatttcatc cacgtccatg cggatctttt ccttttcata 360
caaattatgt aggtcaaaca gcttattaaa acaaagagca cagattaacc accacgtatt 420
tagatactta aaatgttggt aaacataaga aatggcctcc ctaagattat cctgcaatgc 480
cactataaaa cagtatatcg ttaacatatc accatccgac atattactta atatgtcggt 540
gtcttctact aaccttttca acttccaata tatggatgac cttatttccc ttataatgac 600
ataggctgga aagggattat cattaaaaag tttaagacat aagataatat tactgctagt 660
agtgccaggg tgtattaatt taaagaacat gtgcataatc ttctttttat ccacgcggta 720
cttggctcct aattcccagc aaaattctcg aacaggcggc gtattggcgc aaattaaccc 780
atagttgatg tctgcgcccc attctgtaaa cagttttatt aactgatagt tgttttcctt 840
tgtagccaac attagtgccg tattaaggtc caagccgtct gcaaagcttg gcagctttat 900
cagcatatgt ttgcaatcaa gggaaattgg ggccttatac caccatagtc cgcagcgttc 960
taagataaca tggtactcaa tagatacttg ctgtctggct agtacctttt tggcgaagga 1020
ttgtaaggaa ggaaacat 1038
<210> 14
<211> 1071
<212> DNA
<213> 非洲猪瘟病毒
<400> 14
ttacgacgtt gtatcattat tgtgataatc caaataggcc gacatacttt ttgatttata 60
attgtttaat agatggtata tttttttagg gttcgcttct tttagcgtga atagagaggg 120
atctggatga tagatatcta atgacaaacg atgtgatatt aaataatagt cccgctgctc 180
tgctagggct tttgcctctt cgaaggcatt ggcccccaag tctatacaaa agaacagatt 240
atctatatta aaaaactgta tggcagcaag catcgccata ttgatatcgg cccctaaaat 300
aaaacaataa tacatcgtta aaaagttgtt atctttcgtg caagctatgc gcatcatttc 360
attaatgtct atgcgaattt tttcctgctc atagagataa tggaggtcaa acagtttatt 420
aaaacacaga gcacagatta accaccacgt attcaggtgc ttaaaatgtt ggtaaaaata 480
cgagacggcc tccctaagac cattctgcaa ggccaccata aaacaatata aagttagcat 540
atcgccgtcc gaaacatcgc gtagtaggtc ttcgtcttct actaacctcc tcagcctcca 600
ataaagagac gactttattt cccttataat cacataggta ggaaaaggat tctcattaaa 660
aagcttatga cataagataa tatattgact cgttttgttc tctataaatt taaaaaacat 720
atgcatcacc ttttttttat ctaagcgata gttcgctcct aattcccaac aaaactctcg 780
agtaggctgt gtattggcac aaatgtatcc atagttgatg tttgcacccc actccgtgaa 840
cagttttatt aattgatagt tgttttcctt tgcagctatc atcaatgccg tattgaggtc 900
caggccatcc gcaaagtatg gcaaccttat taacatgtgt ttacaatcaa gtgaaattgg 960
agccttatac caccataacc cgcagcgctt caaaatatga tagtagtctt caggcagcac 1020
atgctggctg gctaatatct ttttggcgaa agattgcagg gaaggaaaca t 1071
<210> 15
<211> 1071
<212> DNA
<213> 非洲猪瘟病毒
<400> 15
ttacgacgtt gtatcattga tgtgataatc caaataggcc aacatacttt ttgatttata 60
gttgtttaat agatggtata tttttttagg gttcgcttct tttagcgtga atagagaggg 120
atctggatga tagatatcta atgacaaacg ttgtgatatt aaataatagt cccgctgctc 180
tgctagggct tttgcctctt cgaaggcatt ggctcccaag tctatacaaa agaacagatt 240
atctatatta aagaactgta tggcagcaag catggccata ttgatatcgg cccctaaaat 300
aaaacaataa tacatcgtta aaaagttatt atctttcgtg caagctatgc gcatcatttc 360
attaatgtct atgcgaatct tttcctgctc atagagataa tggaggtcag acagtttatt 420
aaaatacaga gcacagatta accaccacgt attcatgtgc ttaaaatgtt cgtaaaaata 480
cgagacggcc tccctaagat cattctgcaa ggccaccata aaacaatata tagttagcat 540
atcgccgtcc gaaacatcac gtagtaggtc ttcatcttct actaacctcc tcagcctcca 600
ataaagagac gactttattt cccttataat cacataggta ggaaaaggat tctcattaaa 660
aagcttatga cataagataa tatattgact tgttttgttc tctataaatt taaagaacat 720
gtgtatcacc ttttttttat ccatgcgata gttcgctcct aattcccaac aaaactctcg 780
ggtaggctgt gtattggcac aaatgtatcc atagttgatg tttgcacccc actccgtgaa 840
tagttttatt aattgatagt tgttttcctt tgcagctatc atcaatgccg tattgagatc 900
caggccatcc gcaaagtatg gcaaccttat taacatgtgt ttgcaatcaa gtgaaattgg 960
agccgtatac caccataacc cgcagtattt caaaatatga tagtagtctt caggcagcac 1020
atgctgactg gctaatatct ttttggcgaa agactgtaaa gaaggaaaca t 1071
<210> 16
<211> 1071
<212> DNA
<213> 非洲猪瘟病毒
<400> 16
ttacgacgtt gtatcattaa tgtgataatc caaataggcc gacatacttt ttgatttata 60
gttgtttaat agatggtata tttttttagg gttcgcttct tttagcgtga atagagaggg 120
atctggatga tagatatcta atgacaaacg atgtgatatt aaataatagt cccgctgctc 180
tgctagggct tttgcctctt cgaaggcatt ggcccccaag tctatacaaa agaacagatt 240
atccatatta aagaactgta tggcagcaag catggccata ttgatatcgg cccctaaaat 300
aaaacaataa tacatcgtta aaaagttgtt atctttcgtg caagctatgc gcatcatttc 360
attaatgtct atgcgaattt tttcctgctc atagagataa tggaggtcaa acagtttatt 420
aaaacacaga gcacagatta accaccacgt attcaggtgc ttaaaatgtt ggtaaaaata 480
cgagacggcc tccctaagat cattctgcaa ggccaccata aaacaatata aagttagcat 540
atcgtcgtcc gaaacatcgc gtagtaggtc ttcgtcttct actaatctcc tcagcctcca 600
ataaagagac gactttattt cccttataat cacataggta ggaaaaggat tctcattaaa 660
aagcttatga cataagataa tatactgact cgttttgttc tctataaatt taaaaaacat 720
atgcatcacc ttttttttat ctaagcgata gtttgctcct aattcccaac aaaactctcg 780
agtaggctgt gtattggcac aaatgtatcc atagttgatg tttgcacccc actccgtgaa 840
cagttttatt aattgatagt tgttttcctt tgcagctatc atcaatgccg tattgaggtc 900
caggccatcc gcaaagtatg gcaaccttat taacatgtgt ttacaatcaa gtgaaattgg 960
agccttatac caccataacc cgcagcgctt caaaatatga tagtagtctt caggcagcac 1020
atgctggctg gctaatatct ttttggcgaa agattgcagg gaaggaaaca t 1071
<210> 17
<211> 1071
<212> DNA
<213> 非洲猪瘟病毒
<400> 17
ttataacgat gtatcattga tgtcataatt caaataggcc aacatacttt ttgatttata 60
gttttttaat agacgatata ttttgttagg atctgcttct tttaacgtta atagcgagga 120
gtctggacta taaatgtcta atgataaacg atgagatatc aaatagtaat tctgttgctc 180
tgccaaggct tttgcctctt caaaggcatc ggcccccaga tctatacaaa agaacaggtt 240
atccatatta tagaatcgta tggaggcaat catggccaaa ttaatattag ctcctaagat 300
aaaacaataa tatatagtta aaaaattgtt atcttttgtg caggctatcc gcatcatttc 360
atccatgtcc atacggattt tttctttttc gtacaaatta tgtaggtcaa acagcttatt 420
atagcaaaga gcacatgtta accaccacgt attcagatac ttaaaatgtt ggtaaacata 480
agaaatggcc tccctaagat tatcctgcaa tgccacgata aaacagtata tagttaacat 540
atcaccatcc gaaatattac ttaatacgtt ggtatcttct gctaaatttt ttagcttcca 600
atgtatacac gactttattt cccttataat gacataggct gaaaagggat tgtcattaaa 660
aaatttaaga cataagataa tattattact agtagtgtta ggatgtatta atttaaagaa 720
tatgtgcata atcttctttt tatccacttg gtacttggct cctaattccc agcaaaattc 780
tcgaataggt ggcgtattcg cgcaaattaa cccatagttg atgtctgcgc cccaatccgt 840
aaacattttt attaattgat agttgttttc ctttgtagcc aacattagtg ccgtattaag 900
gtccaagcca tctgcaaagt ttggcagctt tatcagcata tgtttgcaat caagtgaaat 960
tggagcctta taccaccata gcccgcagcg ttctaagata acatggtaat caatagatac 1020
atgctgactg gctaatacct ttttggcgaa ggattgcaag gaaggaacca t 1071
<210> 18
<211> 1068
<212> DNA
<213> 非洲猪瘟病毒
<400> 18
ttacactgtg tcatgcccat catagtcaaa atataccatc atattttttg atttatagtt 60
ttttaataga tgatatattt ttttaggatc tgcttctttt aacgttaata gcgaggagtc 120
tggactataa atatctattg ataaacgatg atacatcaaa aagtaattcc gctggtctgc 180
cagggctttt gcctcttcaa aggcatcggc tcccaggtct atacaaaaga acaagttatc 240
catattatag aattgtacgc aggcaagcat agcctgatta atattagctc ctaagagaaa 300
acagtaatat atggttaaaa agttgttatc tttagtgcag gctatgcaca tcatttcatc 360
catgtccatg cggatctttt ccttttcata caaatcatgt aggtcaaaca gcttattaaa 420
acaaagagca cagattaacc accacgtatt cagatgctta aaatgttggt aaaaataaga 480
aatggcctcc ctaagattat cctgcaatgc caggataaaa cagtatatag tcaacatatc 540
atcatccgac atattactta atatgtcagt gtcttctact aaccttctca gcttccaata 600
tatagacgac tttatttccc ttataatgac ataggttgga aaaggattat tattaaaaag 660
tttaagacat aagataatat tactactagt agtgccatga tgtattaatt taaaaaacat 720
atgcataacc ttatttttat ccacttggta cttggctcct aattcccagc aaaattctcg 780
aacaggcggc gtattagcgc aaattaatcc atagttgatg tccgcgcccc attccgtaaa 840
cagttttatt aactgatagt tgttttcctt tgtagccaac attagtgccg tattaaggtc 900
caagccatct gcaaagcttg gcagctttat taacatatgt ttgcaatcaa gtgaaattgg 960
agccttatac caccatagtc cgcaatgttt taagatataa tgataatcaa tggatacatg 1020
atgtctagct aatacctttt tggcgaagga ttgtaaagaa ggaaacat 1068
<210> 19
<211> 1071
<212> DNA
<213> 非洲猪瘟病毒
<400> 19
ttataacgat gtatcattga tgtcataatt caaataggcc aacatacttt ttgatttata 60
gttttttaat agacgatata ttttgttagg atctgcttct tttaacgtta atagcgagga 120
gtctggacta taaatgtcta atgataaacg atgagatatc aaatagtaat tctgttgctc 180
tgccaaggcc tttgcctctt caaaggcatc ggcccccaga tctatacaaa agaacaggtt 240
atccatatta tagaatcgta tggaggcaat catggccaaa ttaatattag ctcctaagat 300
aaaacaataa tatatagtta aaaaattgtt atcttttgtg caggctatcc gcatcatttc 360
atccatgtcc atacggattt tttctttttc gtacaaatta tgtaggtcaa acagcttatt 420
atagcaaaga gcacatgtta accaccacgt attcaaatac ttaaaatgtt ggtaaacata 480
agaaatggcc tccctaagat tatcctgcaa tgccacgata aaacagtata tagttaacat 540
atcaccatcc gaaatattac ttaatacgtt ggtatcttct gctaaatttt ttagcttcca 600
atgtatacac gactttattt cccttataat gacataggct gaaaagggat tgtcattaaa 660
aaatttaaga cataagataa tattactact agtagtgcta ggatgtatta atttaaagaa 720
tatgtgcata atcttctttt tatccacttg gtgcttggct cctaattccc agcaaaattc 780
tcgaataggt ggcgtattcg cgcaaattaa cccatagttg atgtctgcgc cccaatccgt 840
aaacattttt attaattgat agttgttttc ctttgtagcc aacattagtg ccgtattaag 900
gtccaagcca tctgcaaagt ttggcagctt tatcagcata tgtttgcaat caagtgaaat 960
tggagcctta taccaccata gcccgcagcg ttctaagata acatggtgat caatagatac 1020
atgctgactg gctaatacct ttttggcgaa ggattgcaag gaaggaaaca t 1071
<210> 20
<211> 1071
<212> DNA
<213> 非洲猪瘟病毒
<400> 20
ttataacgtt gtattattga cgtcataatt caaataggcc aatatacttt ttgatttata 60
gttttttaat agatgatata ttttgttagg atccgcttct tttaacgtta ataacgagga 120
atctggacta taaatgtcta atgataaaca atgagatatc aaaaagtaat tccgttgctc 180
tgccagggct tttgcctcct caaaggcatc ggcccccagg tctatacaaa agaataagtt 240
atctatgtta tagaattgta tggaggcaat catagctaaa ttaatattag ctcctaagat 300
aaaacaataa tatatggtta aaaaattgtt atcttttgtg caggctatcc gcatcatttc 360
atccatgtcc atgcggatct tttccttttc atacaaatga tgtaggtcaa acaccttatt 420
atagcaaaga acacatgtta accaccacgt attcagatac ttaaaatgtt ggtaaacata 480
agaaatggcc tccctaagat tatcctgcaa tgccacgata aaacagtata tagttaacat 540
atctccatcc gaaatattac ttaatacgtt ggtatcttct gctaactttt ttagcttcca 600
atgtatacac gactttattt cccttataat gacataggct gaaaagggat tgtcattaaa 660
aagtttaaga cataagataa tattactact agtagtgcta ggatgtatta atttaaagaa 720
tatgtgcata atcttctttt tatccacttg gtacttggct cctaattccc agcaaaattc 780
tcgaacaggt ggcgtattcg cgcaaattaa cccatagttg atgtctgcgc cccaatccgt 840
aaacattttt attaattgat agttgttttc ctttgtagcc aacattagtg ccgtattaag 900
gtccaagcca tctgcaaagt ttggcagctt tatcagcata tgtttgcaat caagtgaaat 960
tggagcctta taccaccata gcccgcagcg ttctaagata atatggtgat caatggatac 1020
atgctgtctg gctagtacct ttttggcgaa ggattgtaag gaaggaaaca t 1071
<210> 21
<211> 1071
<212> DNA
<213> 非洲猪瘟病毒
<400> 21
ttataacaat gtatcattga tatcatcatt caaataggcc aacatatttt ttgatttata 60
gttttttaat agatgattta ttttgttagg atctgtttct tttaacgtta atagcaagga 120
gtctggctta taaatgtcta atgataaacg atgagatatt aaatagtaat tccgttgctc 180
tgccagggct tttgcctctt caaaggcgtc ggctcccaga tctatacaaa agaacaagtt 240
atccatatta taaaatcgta cgcaggcaag catagctgaa ttaatattag ctcctaagag 300
aaaacaataa tatatagtta aaaaattgtt atcttttgtg caggccatcc gcatcatttc 360
atccacgtcc atgcggatct tttccttttc atacaaatta tgtaggtcaa acagcttatt 420
aaaacaaaga gcacagatta accaccacgt atttagatac ttaaaatgtt ggtaaacata 480
agaaatggcc tccctaagat tatcctgcaa tgccactata aaacagtata tcattaacat 540
atcaccatcc gacatattac ttaatatgtc ggtgtcttct actaaccttt tcagcttcca 600
atatatggat atccttattt cccttataat gacataggct ggaaagggat tatcattaaa 660
aagtttaaga cataagataa tattactgct agtagtgcca ggatgtatta atttaaagaa 720
catgtgtata atcttctttt tatccacgcg gtgcttggct cctaattccc agcaaaattc 780
tcgaacagac ggcgtattgg cgcaaattaa cccatagttg atgtctgcgc cccattccgt 840
aaacagtttt attaactgat agttattttc ctttgtagcc aacattagtg ccgtattaag 900
gtccaagccg tctgcaaagc ttggcagctt tatcagcata tgtttgcagt caagtgaaat 960
tggagcctta taccaccata gtccgcaacg ttctaagata acatggtact caatagatac 1020
ttgctgtctg gctagtacct ttttggcgaa ggattgtaag gaaggaaaca t 1071
<210> 22
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 22
tcatattgta tcatcatggt taaaatatgc cgtcatattt tttgatttat agttttttaa 60
tagatgatat attttgttag ggtccgcttc ttttaacgtt aatagcgagg agtctggact 120
ataaatgtct aatgataaac gatgagatat caaaaagtaa ttccgttgct ctgccagagc 180
ctttgcctct tcaaaggcgt cggcccccag gtctatacaa aagaacaggt tatccatatt 240
atagaatcgt atggaggcaa tcatggccaa attaatatta gctcctaaga taaaacaata 300
atatatagtt aaaaaattgt tatcttttgt gcaggctatc cgcatcattt catccatgtc 360
catgcggatt ttttcctttt cgtacaaatt atgtaggtca aacagcttat taaaacaaag 420
agcacagatt agccaccaca tattcagata cttaaaatgt tggtaaacat aagaaatggc 480
ctccctaaga ttatcctgca atgccaccat aaaacagtat atcgttaaca tatcaccatc 540
tgaaatatca cttaatacgt cggtgtcttc tactaacttt ctcagcttcc aatatatgga 600
tgactttatt tcccttataa tgacataggc tgaaaagggg ttatcattaa aaagtttaag 660
acataagata atattactgc tagtagtgcc aggatgtatt aatttaaaga acatgtgcat 720
aatcttcttt ttatccacgc ggtacttggc tcctagttcc cagcacaatt ctcgaacagg 780
cggtgtattg gcgcaaatta acccatagtt gatgtctgcg ccccattccg taaacagttt 840
tattaactga tagttgtttt cctttgtagc caacattagt gccgtattaa ggtccaagcc 900
atctgcaaag cttggcagct ttatcagcat atgtttgcaa tcaagtgaaa ttggagcctt 960
ataccaccat agtccgcagc gttctaagat aacatggtaa tcaatagata catgctgtct 1020
ggctagtacc tttttggcga aggattgtaa ggaaggaaac at 1062
<210> 23
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 23
tcatattgta tcatcatggt taaaatatgc cgtcatattt tttgatttat agttttttaa 60
tagatgatat attttgttag ggtccgcttc ttttaacgtt aatagcgagg agtctggact 120
ataaatgtct aatgataaac gatgagatat caaaaagtaa ttccgttgct ctgccagggc 180
ttttgcctct tcaaaggcat cggcccccaa gtctatacaa aagaacaggt tatccatatt 240
ataaaatcgt atggaggcaa tcatggccaa attaatatta gctcctaaga taaaacaata 300
atatatagtt aaaaaattgt tatcttttgt gcaggctatc cgcatcattt catccatgtc 360
catgcggatt ttttcctttt cgtacaaatt atgtaggtca aacagcttat taaaacaaag 420
agcacagatt agccaccacg tattcagata tttaaaatgt tggtaaacat aagaaatggc 480
ctccctaaga ttatcctgca atgccaccat aaaacagtat atcgttaaca tatcaccatc 540
cgaaatatta cttaatacgt cggtgtcttc tactaacttt ttcagcttcc aatatatgga 600
tgactttatt tcccttataa tgacataggc tgaaaagggg ttatcattaa aaagtttaag 660
acataagata atattactgc tagtagtgcc aggatgtatt aatttaaaga acatgtgcat 720
aatcttcttt ttatccacgc ggtacttggc tcctagttcc cagcacaatt ctcgaacagg 780
cggcgtattg gcgcaaatta acccatagtt gatgtctgcg ccccattccg taaacagttt 840
tattaactga tagttgtttt cctttgtagc caacattagt gccgtattaa ggtccaagcc 900
atctgcaaag cttggcagct ttatcagcat atgtttgcaa tcaagggaaa ttggagcctt 960
ataccaccat agtccgcagc gttctaagat aacatggtaa tcaatagata catgctgtct 1020
ggctagtacc tttttggcga aggattgtaa ggaaggaaac at 1062
<210> 24
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 24
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gtaatttatt ttttcagggt ccataacgtt cgacaacaga gaaatgactg gattgtaatg 120
ctttaatgat aaggcatggg ctatcagata attttccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcgttggcgc ccaggtctat acaaaagaac aggtttccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggccgaatag ctataatctt ggatgcaggc tatgtgcatc atttcatcga tatccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc caccgatgta ggcgcgggta tttctggtaa aagtagcgaa tagcatcttt 480
gaggtcatag tccaccgcta tagcatacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtct agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgctactgg ttttatcgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atagtttatt acgtcgaata tgaagcataa tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgaca cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 25
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 25
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcaatttatt ttttcagggt ccgtaacgat cgacaacaga gaaataaccg gattgtaatg 120
ctttaatgat aaggcatggg ctatcagata attttccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcatcggcac ccaggtctat acaaaagaac aggtttccaa gattatagtt 240
ttgtatggaa acaagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggccgaatag ctataatctt ggatgcaggc tatgtgcatc atttcatcaa tatccatgcg 360
gaccctttct atttcgtaca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta gacgcgggta tttctggtaa aagtagcgga tagcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgctactgg ttttatcgcg cgttgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaaacaggtt gaccttataa ataatttatt gcgtcgaata tgaagcataa tggggccatt 960
atgccaccac aggccacaac acttcaggac atgatattga tctaccggta tacactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 26
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 26
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcaatttatt ttttcagggt ccgtaacgat cgacaacaga gaaataaccg gattgtaatg 120
ctttaatgat aaggcatggg ctatcagata attttccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcatcggcac ccaggtctat acaaaagaac aggtttccaa gattatagtt 240
ttgtatggaa acaagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggccgaatag ctataatctt ggatgcaggc tatgtgcatc atttcatcaa tatccatgcg 360
gaccctttct atttcgtaca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta gacgcgggta tttctggtaa aagtagcgga tagcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgctactgg ttttatcgcg cgttgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaaacaggtt gaccttataa ataatttatt gcgtcgaata tgaagcataa tggggccatt 960
atgccaccac aggccacaac acttcaggac atgatattga tctaccggta tacactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 27
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 27
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gtaatttatt ttttcagggt ccataacgtt cgacaacaga gaaatgactg gattgtaatg 120
ctttaatgat aaggcatggg ctatcagata attttccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcgttggcgc ccaggtctat acaaaagaac aggtttccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggccgaatag ctataatctt ggatgcaggc tatgtgcatc atttcatcga tatccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc caccgatgta ggcgcgggta tttctggtaa aagtagcgaa tagcatcttt 480
gaggtcatag tccaccgcta tagcatacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtct agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgctactgg ttttatcgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atagtttatt acgtcgaata tgaagcataa tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgaca cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 28
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 28
ttatctgcgt tcataatcga gaaaaaccac catattcttt gagtgataat tttttaacat 60
agaatttatc ttttctgggt cggtcacggc cgacaacagg gaaatcaccg ggttataatg 120
ttttaatgat aaggcatcgg ctatcaaata attttccttt tgtattgcta gggctttgcc 180
ttcttcaaag gcgttggcac ccaggtctat acaaaagaac atgttcccga gattatagtt 240
ttgtatggaa acaaacatgg cttgattgat gttggccccc atgataaaac agtagtaaat 300
agctgaatag ctataatctt ggatgcaggc tatgtgcatc atctcatcga tatccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacaca ttgttataaa aaagggcgca 420
cataagccgc caccgatgta gatgggtata cttctgataa aaatagtgga tggccttttt 480
gaggccgtag tctaccgcta tggcgtacca gtatttggtt aacatattgc tgaaggagtt 540
gtcatggtcc aacatgtagg ttatttccat gagtcccctt agctcccaca tgatttcctc 600
cctcagatcc aaatcatcca catgtttcag attggcgtta ttggaaaaca tttcgtggca 660
taagataata ttactgtcgg ttttgttgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctatct aaacggtctt tggctccaag ttctctacat agattgcggg tgtgctccga 780
atgagcacaa accagtccat aattaatatc ggcaccccac tcaacaaaca gccttatcaa 840
gtcatgattg ttttccttcg cggctttcat cagtacggtg ttcaattcaa taccctcgct 900
aaaacaggtt gactttataa acattttgtt acgatacgta taaaatgtaa tagggccatc 960
ataccaccac aacccgcagc atttcaggat atgatattga tctaccggta tacactgttt 1020
ggccagcact ttcttggata gggattgcaa ggaaggcaac at 1062
<210> 29
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 29
ttatctgcgt tcataatcga gaaaaaccac catattcttt gagtgataat tttttaacat 60
agaatttatc ttttccgggt cggtcacggc cgacaacagg gaaatcaccg ggttataatg 120
ttttaatgat aaggcatcgg ctatcaaata attttccttt tgtattgcta gggctttgcc 180
ttcttcaaag gcgttggcac ccaggtctat acaaaagaac atgttcccga gattatagtt 240
ttgtatggaa acaaacatgg cttgattgat gttggcaccc atgataaaac agtagtaaat 300
agttgaatag ctataatctt ggatgcaggc tatgtgcatc atctcatcga tatccatgcg 360
gatcctttct atttcataca gctcgtgaag gtcgaacaca ttgttataaa aaagggcgca 420
catgagccgc caccgatgta gatgggtata cttctgataa aaatagtgga tggccttttt 480
gaggccgtag tctaccgcta tggcgtacca gtatttggtt aacatgttgc tgaaggagtt 540
gtcatggtcc aacatgtagg ttatctccat gagtcccctt agctcccaca tgatttcctc 600
cctcaggtcc aaatcatcca catgtttcag attggggtta ttggaaaaca tttcgtggca 660
taagataata ttactgtcgg ttttgttgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctttatct aaacggtctt tggcccctag ttctctgcat agatcgcggg tgtgctccga 780
atgagcacaa accagtccat aattaatatc ggcaccccac tcagtaaata attttattag 840
gtcatgattg ttttccttcg cggctttcat cagtacggtg ttcaattcaa taccctcgct 900
aaaacaggtt gactttataa acattttgtt acgatacgta taaaatgtaa tagggccatc 960
ataccaccac aacccgcaac ttttcaggat atgatattga tctaccggta tacactgttt 1020
ggccagcact tttttggata gggattgcaa ggaaggcaac at 1062
<210> 30
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 30
ttatctgcgt tcataatcga gaaaaaccac catattcttt gagtgataat tttttaacat 60
agaatttatc ttttctgggt cggtcacggc cgacaacagg gaaatcaccg ggttataatg 120
ttttaatgat aaggcatcgg ctatcaaata attttccttt tgtattgcta gggttttgcc 180
ttcttcaaag gcgttggcac ccaggtctat acaaaagaac atgttcccga gattatagtt 240
ttgtatggaa acaaacatgg cttgattgat gttggccccc atgataaaac agtagtagat 300
agctgaatag ctataatctt ggatgcaggc tatgtgcatc atctcatcga tatccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacaca ttgttataaa aaagggcgca 420
cataagccgc caccgatgta gatgggtata cttctgataa aaatagtgga tggccttttt 480
gaggccgtag tctaccgcta tggcgtacca gtatttggtt aacatattgc tgaaggagtt 540
gtcatggtcc aacatgtagg ttatctccat gagtcccctt agctcccaca tgatttcctc 600
cctcagatcc aaatcatcca catgtttcag attggggtta ttggaaaaca tttcgtggca 660
taagataata ttactgtcgg ttttgttgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctatct aaacggtctt tggctccaag ttctctgcat agattgcggg tgtgctccga 780
atgagcacaa accagtccat aattaatatc ggcaccccac tcaacaaaca gccttatcaa 840
gtcatgattg ttttccttcg cggctttcat cagtacggtg ttcaattcaa taccctcgct 900
aaaacaggtt gactttataa acattttgtt acgatacgta taaaatgtaa tagggccatc 960
ataccaccac aacccgcagc atttcaggat atgatattga tctaccggta tacactgttt 1020
ggccagcact ttcttggata gggattgcaa ggaaggcaac at 1062
<210> 31
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 31
ttatcttcgt tcataatcaa gaaaaaccct catatttatt gagtgataat tttttaacat 60
gcaatttatt ttttcagggt ccataatgac cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcatcgg ctatcagata attttccttt tgttctgcca aagctttccc 180
ctcctcaaag gcgttggccc ccagatctat acaaaagaac atgttcccaa gattatagtt 240
ttgtatagaa acaagcatgg cttgattgat gttggccccc atgataaaac agtaataaat 300
agccgcatag ctataatctt ggacgcaggc tatgtgcatc atttcatcaa tatccatgcg 360
gaccctttct attacataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
cataagccgc cagtggtgta gatgggtata cctctgataa aaataatgga tagccttttt 480
gaggccatag tctaccgcta tggcgtacca gtatttggtt aacatattgc taaaggagtt 540
gtcatggtcc aacatgtagg ttatctccat gagtcccctt agctcccaca tgatttcctc 600
cctcagatcc aaattatcca catttttcag gttggggtta ttggaaaaca tttcgtggca 660
taagataata ttactgtcgg ttttgttgcg cgtcgtatca aagaaaattt ttaaaatata 720
atctctatct aaacgatctt tggctcctag ttctctgcat agattacggg tgtgctccgt 780
atgggcacaa atcagtccat aattaatatc ggcaccccac tcggcaaaca gccttatcaa 840
gtcatggttg ttttccttcg cggctttcat cagtacggtg ttcaattcaa taccctcgct 900
aaaacaggtt gaccttataa acattttgtg acgataaacg taaaatgtaa tagggccatc 960
ataccaccac aacccgcagc actttaagac atgatattga tctaccggta cacactgttt 1020
ggccagcact ttcttagtta aagattgtaa ggaaggcaac at 1062
<210> 32
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 32
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gtaatttatt ttttcagggt ccataacgat cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcatggg ctatcagata atttcccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcgttggcgc ccaggtctat acaaaagaac aggtttccaa gattatagtt 240
ttgtatggaa accagcatag cttgattgat gttggctccc atgataaaac agtagtaaat 300
gaccgaatag ctataatctt ggatgcaggc tatgtgcatc atttcatcaa tatccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta ggcgcgggta tttctggtaa aagtagcgaa tagcatcttt 480
gaggtcatag tccaccgcta tagcatacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtct agcatgaagg ttatctccat gagccctctt aactcccaca tgatttctcc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgctactgg ttttatcgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atagtttatt acgtcgaata tgaagcataa tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgaca cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 33
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 33
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcgatttatt ttttcagggt ccgtaaccac cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcattgg ctatcagata atttcccttt tgttctgcca aagctttgcc 180
ctcttcaaag gcgttggcac ccaggtctat acaaaagaac aggttcccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggctgaatag ctataatctt ggacgcaggc tatgtgcatc atttcatcaa tgtccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta gccgcgggta tttctggtaa aagtagcgga tagcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgttactgg ttttatcgcg cgttgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atattctatt acgtcgaata tgaagcatta tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tctaccgaca cgcactgccc 1020
agccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 34
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 34
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcaatttatt tttttagggt ctgtaacgac cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcatcgg ctatcagata atttcccttt tgttctgcca aagctttgcc 180
ttcctcaaag gcgttggctc ccaggtctat acaaaagaac aggttcccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggccgaatag ctataatctt ggacgcaggc tatgtgcatc atttcatcaa tgtccatgcg 360
gaccctttct atttcgtaca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta gacgcgggta tttctggtaa aagtagcgga tcgcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgttactgg ttttatcgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggcacccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atagtttatt acgtcgaatc tgaagcataa tgggtccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgaca cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 35
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 35
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcgatttatt ttttcagggt ccgtaaccac cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcattgg ctatcagata atttcccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcgttggcac ccaggtctat acaaaagaac aggttcccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtagat 300
ggctgaatag ctataatctt ggacgcaggc tatgtgcatc atttcatcaa tgtccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta gccgcgggta tttctggtaa aagtagcgga tagcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgttactgg ttttatcgcg cgttgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atattctatt acgtcgaata tgaagcatta tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgaca cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 36
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 36
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcgatttatt ttttcagggt ccgtaaccac cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcattgg ctatcagata atttcccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcgttggccc ccaggtctat acaaaagaac aggttcccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggctgaatag ctataatctt ggacgcaggc tatgtgcatc atttcatcaa tgtccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagagcgca 420
catgagccgc cacctatgta gccgcgggta tttctggtaa aagtagcgga tagcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtac taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttctcc 600
ccttagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgttactgg ttttatcgcg cgttgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atattctatt acgtcgaata tgaagcatta tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgata cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 37
<211> 1053
<212> DNA
<213> 非洲猪瘟病毒
<400> 37
tcatcttaaa tcataggaaa ggaagatcat catatttttt gaaaagtaat tttttaacgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg atggtggtcg gactataaat 120
ctttagagat aaaatgtttt ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatccataca aaagaacatg ttttctatat tatagtactg 240
tattgaggta agcatggcct gattgatgtt ggcgcccaac atatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcaat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catggaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcatgt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gctatagcgt acggctatag cgtaccagta tttgagtagt aatgtactga gcaaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
caatttcaga ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctatg aaaatttgta aaatttcctc 720
ttcattcaag atctccttgg cacctaactc ttgacagagg tcccgggtat gctccgtgtt 780
gacagatacc agcccatagt tgatgtccgc cccccactct gtaaatagtt ttataaggct 840
gtagttgttt tcccttacag cctttactaa cgccgtattt aggtctaagc cctctttaat 900
gcctgatgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat tataccacca 960
tagatcataa tattttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc aaagattgca gggaaggcaa cat 1053
<210> 38
<211> 1053
<212> DNA
<213> 非洲猪瘟病毒
<400> 38
tcatcttaaa tcataggtaa ggaagatcat catatttttt gaaacgtaat tttttaacgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatctataca aaagaacatg ttttctatat tatagtactg 240
tattgagcta agcatggctt gattgatgtt ggcgcccagg acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagt aatgtactga gcgaaaactc 540
attatttagc agatcggttt ttactattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtttccttgg cacctagctc tcgacagagg tcccaggtgt gctccgtgtt 780
gacagatacc agcccgtagt tgatgtccgc cccccactct gcaaacagtt ttataaggtt 840
gtagttgttt tcccttacag ccttcactaa cgccgtattt aggtttaagc cctctttaat 900
acctgctgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat catgccacca 960
taggtcataa cactttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 39
<211> 1053
<212> DNA
<213> 非洲猪瘟病毒
<400> 39
tcatcttaaa tcataggtaa ggaagatcat catatttttt gaaacgtaat tttttaacgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatctataca aaagaacatg ttttctatat tatagtactg 240
tattgagcta agcatggctt gattgatgtt ggcgcccagg acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagt aatgtactga gcgaaaactc 540
attatttagc agatcggttt ttactattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtttccttgg cacctagctc tcgacagagg tcccaggtgt gctccgtgtt 780
gacagatacc agcccgtagt tgatgtccgc cccccactct gcaaacagtt ttataaggtt 840
gtagttgttt tcccttacag ccttcactaa cgccgtattt aggtttaagc cctctttaat 900
acctgctgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat catgccacca 960
taggtcataa cactttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 40
<211> 1056
<212> DNA
<213> 非洲猪瘟病毒
<400> 40
tcatcttaga tcataagtaa ggaagaccat catatttttt gaaaagtaat tttttaacgc 60
atgatctata atttcagggt ccgtgctttt aggcaatggg gtagtggccg ggctataaat 120
ctttagggat aaaatattcc ttataggctc atacccttcc tgtcccacta gagccatacc 180
ctcttcaaaa gcatcggccc ccagatccat acaaaagaat atgttttcta tattatagta 240
ctgtattgag gtaagcatgg cctgattgat gttggcgccc agcatatagc agtagtatat 300
tgttgaaagg ttgtggtctt tgatgcaggc tatccgcatc atctcttcta aatccataca 360
gatcttgtcc ttttcatacg cctcatgaag gtcaaacacg ttattaaaac aaagagcaca 420
tgttaaccgc cacgtattca ggtgtgtata tttttggtaa aaatactgta tggcctcttt 480
caagttgtag cgtacggcta tagcgtacca gtatttgagt aatagtgtat tgagcgaaaa 540
ctcattattt agcagatcgg ttttttctat tatctccctt aactcccaaa aaatttctat 600
cctcattttc aggttattta ccctttttaa aagtaaatta tcggaaaaca cctcatgaca 660
taagataatg ttactactgg ttttataaaa ttttaaatct atgaaaattt gtaaaatatc 720
cccttcattt aaggtcttct tggcgcctag ctctcgacag aggtcccagg tgtgctccgt 780
gttgacagat atcagcccgt agttaatgtt cgccccccac tccgtaaata gttttataag 840
actgtagttg ttttccttta cagccttcac taatgccatg tttaggtcta agccttcttg 900
aatgcctgct aattttatca gccttaggtt atgatcaaac gtgatcggag cattattcca 960
ccatagatcg taacacttta aaagataatg ttggtcctcg ggcagacatt gtctagccag 1020
cacctttttg gtcaaagatt gcagggaagg caacat 1056
<210> 41
<211> 1056
<212> DNA
<213> 非洲猪瘟病毒
<400> 41
tcatcttaga tcataagtaa ggaagaccat catatttttt gaaaagtaat tttttaactc 60
atgatctata atttcagggt ccgtgctttt aggcaacggg gtggtggccg ggctataaat 120
ctttagggat aaaatattcc ttataggctc atacccttcc tgtcccacta gagccatacc 180
ctcttcaaaa gcatcggccc ccagatccat acaaaagaat atgttttcta tattatagta 240
ctgtattgag gtaagcatgg cctgattgat gttggcgccc agcatatagc agtagtatat 300
cgttgaaagg ctgtggtctt tgatgcaggc tatccgcatc atctcttcta aatccataca 360
gatcttgtcc ttttcatacg cctcatgaag gtcaaacacg ttattaaaac aaagagcaca 420
tgttaatcgc cacgtattca ggtgcgtata tttttggtaa aaatactgta tggcctcttt 480
caagttgtag cgtacggcta tagcgtacca gtatttgagt aatagtgtat tgagcgaaaa 540
ctcattattt agcagatcgg ttttttctat tatctccctt aactcccaaa aaatttctat 600
cctcattttc aggttattta ccttttttaa aagtagatta tcggaaaaca cctcatgaca 660
taagataatg ttactactgg ttttatgaaa ctttaaatct atgaaaattt gtaaaatatc 720
cccttcattt aaggtcttct tggcgcctag ctctcgacag aggtcccagg tgtgctccgt 780
gttgacagat atcagcccgt agttgatgtt cgctccccac tccgtaaata gttttataag 840
actgtagttg ttttccttta cagccttcac taatgccatg tttaggtcta agccttcttg 900
aaggcctgct gattttatca gccttaggtt atgatcaaac gtgatcggag cattattcca 960
ccatagatcg taacacttta aaagataatg ttggtcctcg ggcagacatt gtccagccag 1020
cacctttttg gtcagagatt gcagggaagg caacat 1056
<210> 42
<211> 1053
<212> DNA
<213> 非洲猪瘟病毒
<400> 42
tcatcttaaa tcataggaaa ggaagatcat catatttttt gaaaagtaat tttttaacgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg atggtggtcg gactataaat 120
ctttagagat aaaatgtttt ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatccataca aaagaacatg ttttctatat tatagtactg 240
tattgaggta agcatggcct gattgatgtt ggcgcccaac atatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcaat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catggaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gctatagcgt acggctatag cgtaccagta tttgagtagt aatgtactga gcaaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
caatttcaga ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctatg aaaatttgta aaatttcctc 720
ttcattcaag atctccttgg cacctaactc ttgacagagg tcccgggtat gctccgtgtt 780
gacagatacc agcccatagt tgatgtccgc cccccactct gtaaatagtt ttataaggct 840
gtagttgttt tcccttacag cctttactaa cgccgtattt aggtctaagc cctctttaat 900
gcctgatgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat tataccacca 960
tagatcataa tattttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc aaagattgca gggaaggcaa cat 1053
<210> 43
<211> 1050
<212> DNA
<213> 非洲猪瘟病毒
<400> 43
tcatcttaaa tcgtaggaaa ggaaggtcat catatttttt gatttataat tttttaacac 60
atgatctatt atttcagggt ccgtgttttt aggtaacggg gcagtggacg gactatagat 120
ctttagggat aaaatgttcc ttataagctc atacccttcc cctacaggca tattctcttc 180
gaaaacatca gcccccagat ccatacaaaa gaacatgttt tctatattat agtactgtat 240
tgaggcaagc atggcctgat taatgttggc gcccaggaca tagcagtagt atatcgttga 300
aaggttgtgg tctttgatgc aggctactcg catcatctct tctaagtcca tatagatctt 360
gtccttttca tacgcctcat gaaggtcaaa cacattatta aaacaaagag cacatgttaa 420
ccgccacgta ttcaggtgtg tatatttttg ataaaaatac tgtatggcct ctttcaggtt 480
atagcgtacg gctatagcgt accagtattt gagtaataat gtattgagtg aaaactcatt 540
atttaacaga tcggtttttt ttattaactc ccttaactcc cagaaaattt ctatcctcat 600
tttcagatta tttacttttt gtaataacgg attgttggaa aacacctcat ggcataaaat 660
aatgttacta ctagttttat aaaactttag atcgatgaaa attcgtaaaa tttcctcttc 720
atttaaggtc tccttggcgc ctagctctct gcagaggtcc cgggtgtgct ccgtgttgac 780
agataccagc ccgtagttga tgtccgcccc ccactctgta aaaagcttta taaggttgta 840
gttgttttcc cttacagcct ttactaacgc cgtatttagg tctaagccat ctttaatgcc 900
tgctgatttt atcagcccta ggttatgatc aaacgtgatc ggagaatcat accaccatag 960
gtcgtaacac tttaaaagat aatattggtc cgtcggcagg cattgtccag ccagtacctt 1020
tttggtcaga gattgcaggg aaggcaacat 1050
<210> 44
<211> 1053
<212> DNA
<213> 非洲猪瘟病毒
<400> 44
tcatcttaaa tcataggaaa ggaagatcat catatttttt gaaaagtaat tttttaacgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg atggtggtcg gactataaat 120
ctttagagat aaaatgtttt ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatccataca aaagaacatg ttttctatat tatagtactg 240
tattgaggta agcatggcct gattgatgtt ggcgcccaac atatagcagt agtacatggt 300
tgaaaggttg tggtctttaa tgcaggcgat ccgcatcatc tcttctatgt ccatatagat 360
cttgtccttt tcatacgcct catggaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cttctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagc aatgtactga gcgaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccaaaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttt 720
ttcattcaag gtctccttgg cacctagctc tcgacagagg tcccaggtgt gctccgagct 780
gacagatacc agcccatagt tgatgtccgc cccccactct gcaaacaatt ttataaggtt 840
gtagttgttt tcctttacag ccttcaccaa cgccgtattt aggtctaagc cctctttaat 900
gcctgctgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat catgccacca 960
taggtcataa tattttaaaa gataatgttg gttcgtgggc acgcattgtc cggccaacac 1020
ctttttggtc aaagattgca gggaaggcaa cat 1053
<210> 45
<211> 1053
<212> DNA
<213> 非洲猪瘟病毒
<400> 45
tcatcttaaa tcgtaggtaa ggaagatcat catatttttt gaaacgtaat tttttaacgc 60
atgatctata atttcagggt ccgtgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctt atacccttcc cctaaagcta tagtgccctc 180
ttcgaaagca tcagccccca gatccataca aaagaacatg ttttctatat tatagtactg 240
tattgaggta agcatggcct gattgatgtt gccccccagg acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatgaat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttaagtagt aatgtactga gcgaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtctccttgg cacctagctc tcgacagagg tcccaggtgt gctccgtgtt 780
gacagatacc agcccatagt tgatgttcgc cccccactct gcaaacagtt ttataaggtt 840
gtagttgttt tcccttacag ccttcactaa cgccgtattt aggtctaagc cctctttaat 900
gcctgctgat tttatgagct ttaggttatg atcaaacgtg atcggaccat catgccacca 960
taggtcgtaa cactttaaaa gataatgttg gtttgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 46
<211> 1053
<212> DNA
<213> 非洲猪瘟病毒
<400> 46
tcatcttaaa tcataggtaa ggaagatcat catatttttt gaaacgtaat tttttaacgc 60
atgatctatg atttcagggt ccatgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatctataca aaagaacatg ttttctatat tatagtactg 240
tattgagcta agcatggcct gattgatgtt ggcgcccagg acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagt aatgtactga gcgaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtctccttgg cacctagctc tcgacagagg tcccaggtgt gctccgtgtt 780
gacagatacc agcccgtagt tgatgtccgc cccccactct gcaaacagtt ttataaggtt 840
gtagttgttt tcccttacag cctttactaa cgccgtattt aggtttaagc cctctttaat 900
acctgctgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat catgccacca 960
taggtcataa cactttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 47
<211> 1053
<212> DNA
<213> 非洲猪瘟病毒
<400> 47
tcatcttaaa tcgtaggtaa ggaagatcat catatttttt gaaacgtaat tttttaccgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctt atacccttcc cctaaagcta tagtaccctc 180
ttcgaaagca tcagccccca gatccataca aaagaacatg ttttctacat tatagtactg 240
tattgaggta agcatggcct gattgatgtt ggcgcccaga acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatagat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccat gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagt aatgtactga gcgaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtctccttgg cacctagctc tcgacagagg tcccgggtgt gctccgtgtt 780
gacagatacc agcccatagt tgatgtccgc cccccactct gcaaacagtt ttataaggtt 840
gtagttgttt tcccttacag ccttcactaa cgccgtattt aggtctaagc cctctttaat 900
gcctgctgat tttatgagct ttaggttatg atcaaacgtg atcggaccat catgccacca 960
taggtcataa cactttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 48
<211> 1053
<212> DNA
<213> 非洲猪瘟病毒
<400> 48
tcatcttaaa tcgtaggtaa ggaagatcat catatttttt gaaacgtaat tttttaacgc 60
atgatctata atttcagggt ccgtgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctt atacccttcc cctaaagcta tagtgccctc 180
ttcgaaagca tcagccccca gatccataca aaagaacatg ttttctatat tatagtactg 240
tattgaggta agcatggcct gattgatgtt ggcgcccagg acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagt aatgcactga gcgaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtctccttgg cacctagctc tcgacagagg tcccgggtgt gctccgtgtt 780
gacagatacc agcccatagt tgatgttcgc cccccactct gcaaacagtt ttataaggtt 840
gtaattgttt tcccttacag ccttcactaa cgccgtattt aggtctaagc cctctttaat 900
gcctgctgat tttatgagct ttaggttatg atcaaacgtg atcggaccat catgccacca 960
taggtcataa cactttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 49
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 49
ctataatata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttttt cggggtcctt taagtttaat ggcaaggaag catctgaact 120
gtaaatatcc aaagtcaagc tatggcttaa aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgacgtt 240
ataatattgt actgaagtga gcatagcttg gttgatgttg ccccccaggg cgtaacagta 300
atatattgtt aatagattgt tatccttggc acaagccaga catatcatgt catggacgtc 360
tatttggact tttttcttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccact cgttaagatc cgtatatttc tcatctagaa agcaaatggc 480
gttcttacaa acgtattgta ctgctttggc ataccaatac ttcactagta aatcatttaa 540
ctcgtccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtataaca aatttgtttt ctaacatagg attattcata aaaatttcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cctggtgaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ctatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc cacacgaagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattc ggccacgatc catacaaagc ttgagaggag catcatgcca 960
ccataggcca caatatttca aaatgcagtg ttcatctatt gacaaacact ggctggctac 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 50
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 50
ctatagtata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gtaaatatcc aaagccaaac tatggctcag aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccagcg cgtaacagta 300
atatattgtt aatggattgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggatg ttttccttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cattaagatc cgtatatttc tcatctagaa aacaaatggc 480
gtccttacaa tcgtattgta ctgctttggc gtaccaatac ttcactagta aaccatttaa 540
ctcgtccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtataaca aatttgtttt ctaaaatagg attattcata aaaatttcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cctggtaaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ccatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc cacacgaagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattc ggccacgatc catacaaagc ttgagaggag catcatgcca 960
ccataggcca caatatttca aaatgcagtg ttcatctatt gacaaacact ggctggctat 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 51
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 51
ctatagtata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gtaaatatcc aaagccaaac tatggctcag aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccagcg cgtaacagta 300
atatattgtt aatggattgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggatg ttttccttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cattaagatc cgtatatttc tcatctagaa aacaaatggc 480
gtccttacaa tcgtattgta ctgctttggc gtaccaatac ttcactagta aaccatttaa 540
ctcgtccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtataaca aatttgtttt ctaaaatagg attattcata aaaatttcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cctggtaaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ccatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc cacacgaagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattc ggccacgatc catacaaagc ttgagaggag catcatgcca 960
ccataggcca caatatttca aaatgcagtg ttcatctatt gacaaacact ggctggctat 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 52
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 52
ttagagtatt ttatgagagt aatccagaat gatggataaa ttttttgatt tataattttt 60
taataaactg cttatttctt cgggatcctt taagtttaat ggcaaggaag catctgagct 120
ataaatattc aaaaccaaac tatggcttaa aaaattataa ccattttgtc tcgctatggc 180
actaccctct tcaaaggcat taccacccaa atctatacag aaatatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg attgatgttg ccccccaggg cataacaata 300
atatattgtt aatagattgt tatccctgat acaagccaga gataacattt cattgacgtc 360
tatttggatt ttttccttgt ggtatatatc atgaagctca tatattttgt tataacatag 420
gtaacatttt aatcaccatt catcaagatc cgtatatttt tcatccagaa agcaaatggc 480
atctttatgg tcgtattgta ctgcattggc gtaccaatat ttcactagca attcgcttaa 540
ctcgtccgtt tcttttattt ctataagccc gcatagtctt ttataaatta agcgccttaa 600
ttgtgcagca aagttgtttt ctaaattagg attatttata aatatctcat ggcacaaaat 660
aatactgccg ctagttttat tatgcattat cttgttgaaa atacagaaaa tatcgtagtc 720
gtctagagtt tctttggcgc ctagctgtct acacaaatct cgggcgtgct tcgtattgat 780
agaaagcaga ctatagttga tatatgcgcc ccactctgta aataacttta tcatactata 840
gttgttttcc ttaacagcta ttattaatgc cacacaaagg tctatatctt ctcctaggaa 900
tcccgatttt atgtatattc gcccacgatc tatgtaaagc ttgaggggag catcatgcca 960
ccataagcca cagtatttca aaatgtgttc atctatcgac aaacatgatg taccggctac 1020
cgtctttttg acgagggtct gcagagagag cggcgacgac at 1062
<210> 53
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 53
ttagagtatt ttatgagagt aatccagaat gatggataaa ttttttgatt tataattttt 60
taataaactg cttatttctt cgggaacctt taagtttaat ggcaaggaag catctgagct 120
ataaatattc aaaattaaac tatggcataa aaaattataa ccattttgtc tcgctatggc 180
actaccctct tcaaaggcat taccacccaa atctatacag aaatatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccaggg cataacaata 300
atatattgtt aatagattgt tatccctgat acaagccaga gataacattt cattgacgtc 360
tatttggatt tttttcttgt ggtatatatc atgaagctca tatattttgt tataacatag 420
gtaacatttt aatcgccatt catcaagatc cgtatatttt tcatccagaa agcaaatggc 480
atctttatga tcgtattgta ctgcattggc gtaccaatat ttcactagta attcgcttaa 540
ctcgtccgtt tcttttattt ctataagccc gcataatctt ttataaatta agcgccttaa 600
ttgtgcagca aagttgtttt ctaatttagg attatttata aatatctcat ggcacaaaat 660
aatactgccg ctagttttat tatgcattat tttattgaaa atacagaaaa tatcgtagtc 720
gtctagagtt tctttggcgc ctagctgtct acacaaatct cgggcgtgct tcgtattgat 780
agaaagcaga ctatagttga tatatgcgcc ccactctgta aataacttta tcagactata 840
gttattttcc ttaacagcta ttattaatgc cacacaaagg tctatatctt ctcctaggaa 900
tcccgatttt atgtatattc gtccacgatc tatgtaaagc ttgaggggag catcatgcca 960
ccataagcca cagtatttca aaatgtgttc atctatcgac aaacatgatg tactggctac 1020
cgtctttttg acgagggtct gcagagagag cggcgacgac at 1062
<210> 54
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 54
ctataatata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttttt cggggtcctt taagtttaat ggcaaggaag catctgaact 120
gtaaatatcc aaagtcaagc tatggcttaa aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgacgtt 240
ataatattgt actgaagtga gcatagcttg gttgatgttg ccccccaggg cgtaacagta 300
atatattgtt aatagattgt tatccttggc acaagccaga catatcatgt catggacgtc 360
tatttggact tttttcttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccact cgttaagatc cgtatatttc tcatctagaa agcaaatggc 480
gttcttacaa acgtattgta ctgctttggc ataccaatac ttcactagta aatcatttaa 540
ctcgtccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtataaca aatttgtttt ctaacatagg attattcata aaaatttcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cctggtgaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ctatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc cacacgaagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattc ggccacgatc catacaaagc ttgagaggag catcatgcca 960
ccataggcca cagtatttca aaatgcagtg ttcatctatt gacaaacact ggctggctac 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 55
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 55
ttagagtata ttatgagagt aatccaaaat gatggataaa ttttttgatt tataattttt 60
taacaaactg cttatttctt cggggtcctt taagtttaat ggcaaggaag catccgagct 120
ataaatattc aaaaccaaac tatggcttag aaaattataa cctttttgtc tcgctatggc 180
actaccctct tcaaaggcat taccacccaa atctatacag aaatatatat taccgatgtt 240
ataatattgc actgaagtaa gcatagcttg gttgatgttg ccccccaggg cataacagta 300
atatattgtt aatggattgt tatccctgat acaagccagg gataacattt cattaacgtc 360
tatttggatt ttttccttgt ggtatatatc atgaagctca tatattttgt tataatatag 420
gtaacatttt aatcgccatt cattaagatc cgtatatttc tcatccagaa agcaaatggc 480
atctttataa tcgtattgta ctgctttggc gtaccaatat ttcactagta attcacttaa 540
ctcgtccgtt tcttttattt ctataagccc gcatagtctt ttataaatta agcgccttaa 600
ttgtgcagca aatttgtttt ctaaattagg attatttata aatatctcat ggcacaaaat 660
aacactgccg ctggttttat tatgcattat cttgttgaaa atacagaaaa tatcgtagtc 720
ctccagagtt tctttggcgc ctagctgtct acacaaatct cggacgtgct tcgtattgat 780
agaaagcaga ctatagttga tatttgcgcc caactctgta aaaagcttta ttagattata 840
gttgttttcc ttaacagcta ttattaatgc cacacaaagg tctatatctt ctcctaaaaa 900
tcccgatttt atttgtattc ggccacgatc catataaagc ttgagagggg catcatgcca 960
ccataagtca cagtatttca aaatgtgttc atctatcgac aaacatgatg tactggctac 1020
cgtctttttg acgagggttt gtagagagag cggcgccgac at 1062
<210> 56
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 56
ctataatata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttctt cggggtcctt taagtttaat ggcaaggaag catctgaact 120
gtaaatatcc aaagtcaagc tatggcttaa aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccccccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtga gcatagcttg gttgatgttg ctccccaggg cgtaacagta 300
atatattgtt aatagattgt tatccttggc acaagccaga catatcatgt catggacgtc 360
tatttggact tttttcttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cgttaagatc cgtatatttc tcatctagaa agcaaatggc 480
gttcttacaa acgtattgta ctgctttggc ataccaatac ttcactagta aatcatttaa 540
cttgtccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtataaca aatttgtttt ctaaaatagg attattcata aaaatttcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cctggtgaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ctatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc cacacgaagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattc ggccacgatc catacaaagc ttgagaggag catcatgcca 960
ccataggcca cagtatttca aaatgcagtg ttcatctatt gacaaacact ggctggctac 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 57
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 57
ctatagtata ttatgagaat attcccaaat tatggataag ttttttgatt tataatcctt 60
taaaaaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gaaaatatcc aaagccaaac tatggcttag aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt attgaagtaa gcatagcttg gttgatgttg ccccccaggg cgtaacagta 300
atatattgtt aatggattgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggact ttttccttgt ggtacatctc atgaagctca tatattttgt taaaatacag 420
gagacatttt aatcgccatt cattaagatc cgtatatttc tcttctagaa agcaaatggc 480
gtccttacac tcgtattgta ctgctttggc gtaccaatac ttcactagta aatcgtttaa 540
ctcatccgtt tcttttattt ctatgagccc ccatagtctt ttacaaatta agccccttaa 600
ttgtatagta aatttgtttt ctatattagg attattcata aatatatcat ggcacaaaat 660
aatacggccg ctggttttat tgtgcattat cttggtgaaa atacggaaaa catcgtcgtc 720
ttctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct ccgtattaat 780
agaaagcaaa ctatagttga tatgtgcgcc ccattctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc tatatggagg tctatatcct ctcctaaaaa 900
tcctgatttt atttgtattt ggccacgatc catacaaagc ttgaggggga catcatgcca 960
ccataggcca cagtgtttca gaatgcagtg ttcatctatc gacaaacact ggctggctac 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 58
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 58
ctatagtata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gtaaatatcc aaagccaaac tatggctcag aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccagcg cgtaacagta 300
atatattgtt aatgggttgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggatg ttttccttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cattaagatc cgtatatttc tcatctagaa agcaaatggc 480
gtccttacac tcgtattgta ctgctttggc gtaccaatac ttcactagta aaccgtttaa 540
ctcatccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtatagta aatttatctt ctatattagg attattcata aatatatcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cttggtgaaa atacggaaaa tatcgtcgtc 720
ttctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ctatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc tatatggagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattt ggccacgatc catacaaagc ttgaggggga catcatgcca 960
ccataggcca cagtgtttca gaatgcagtg ttcatctatc gacaaagact ggttggctac 1020
cgtctttttg acgagggtct gcagagagag cggtaatgac at 1062
<210> 59
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 59
ctatagtata ttatgagaat attcccaaat gatggataag ttttttgatt tataaccctt 60
taataaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gtaaatatcc aaagccaaac tatggcttag aaaatgataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccaggg cgtaacagta 300
atatattgtt aatggattgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggact ttatccttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cattaagacc cgtatatttc tcatctagaa agcaaatggc 480
gtccttacac tcgtattgta ctgctttggc gtaccaatac ttcactagta aatcgtttaa 540
ctcatccgtt tcttttattt ctatgagcct ccatagtctt ttacaaatta agccccttaa 600
ttgtatagta aatttgtttt ctatattagg attattcata aatatctcat ggcacaaaat 660
aatacggccg ctggttttat tgtgcattat cttggtgaaa atacggaaaa tatcgttgtc 720
ctctagagtt tttttggcac ctagctgtct acacaactct cggatgtgtt ccgtattgat 780
agaaagcaaa ctatagttga tatgtgcgcc ccattctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc tacatggaga tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattt ggccacgatc catacaaagc ttgaggggga catcatgcca 960
ccataggcca cagtgtttca gaatgcagtg ttcatctgtc gacaaacact ggctggctac 1020
cgtttttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 60
<211> 1062
<212> DNA
<213> 非洲猪瘟病毒
<400> 60
ctatagtata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcctt 60
taataaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gtaaatatcc aaagtcaaac tatggcttag aaaatgataa cctttttgtt ccgctatagc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccaggg cgtaacaata 300
atatattgtt aatggattgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggact ttttccttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cattaagatc cgtatatttc tcatctagaa agcaaatggc 480
gtccttacac tcgtattgta ctgctttggc gtaccaatac ttcactagta aatcgtttaa 540
ctcatccgtt tcttttattt ctatgagccc ccatagtctt ttacaaatta agccccttaa 600
ttgtatagta aatttgtttt ctatattagg attattcata aatatctcat ggcacaaaat 660
aatacggccg ctggttttat tgtgcattat cttggtgaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcac ctagctgtct acacaactct cggatgtgct ccgtattgat 780
agaaagcaaa ctatagttga tatgtgcgcc ccattctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc tatatggagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattt ggccacgatc catacaaagc ttgaggggga catcatgcca 960
ccataggcca cagtgtttca gaatgcagtg ttcatctgtc gacaaacact ggctggctac 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 61
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 61
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcatatt 60
ttttgaagta tatgtcttta gcatatcata tatttcctgg ggttcggtta catctaatac 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatga gttgtgccct atcaaaatcg gcggccccca aatcaataca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccccaac ctatgacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc taatgcaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagagctgat ttttatgcct 480
tttataaaaa tagtggatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggaggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt taggttggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgtcaagcc tcccagttcc gcacacagcc gctttagata 780
cacggcagga acacgtataa gcccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagttca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaact tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 62
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 62
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcagatt 60
ttttgaagta tatgtcttta gcatatcata tatttcctgg ggttcggtta catctaatac 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatga gttgtgccct atcaaaatcg gcagccccca aatcaataca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccccaac ctatgacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc tgatgcaaat ctctttttca cgacacaact cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttatagaaa tagtgaatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggtggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagc agaactcctg cacaggattt tagcctggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgttaagcc tcccagttcc gcacacagcc gctttagata 780
cacggcagga acacgtataa gcccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagttca agattatcgc tcttcacggc ctttactagc gccgcttcga gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaact tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 63
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 63
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcagatt 60
ttttgaagta tatgtcttta gcatatcata tatttcctgg ggttcggtta catctaatac 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatga gttgtgccct atcaaaatcg gcagccccca aatcaataca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccccaac ctatgacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc tgatgcaaat ctctttttca cgacacaact cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttatagaaa tagtgaatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggtggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagc agaactcctg cacaggattt tagcctggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgttaagcc tcccagttcc gcacacagcc gctttagata 780
cacggcagga acacgtataa gcccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagttca agattatcgc tcttcacggc ctttactagc gccgcttcga gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaact tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 64
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 64
ttagtctata acgacaattt ctggatgggc tgtaaaatac tcttcggctc gttttagatt 60
ttttgacgta tatgtcttta gcatatcata tattgcctgg ggttcggtta tatttaatac 120
caagctcgca tcacggctga aaagctgttt tactaaaaaa atgttgctca agttatacat 180
ataaactcta tgcgcaatga gtcgcgctct atcaaagtta gtagccccca aatcaatgca 240
gaaaaatagg tttaaagtat tattgttata gatagataga ttcatgccat aatcgggact 300
agcccccaac atatgacagt aataaatggc tgcataattt tcttcccgca ggcaagcaaa 360
tttcatcatt agattagggc taatgcaaat ctctttttta gaacacagct catgcaagtc 420
aaaaatgtta ttaaaataaa ggctacaagt tagccgccaa tacagctgat ttttatgttt 480
ttcgtagaaa tagtgaatcg cttttgtaaa attatgccgt aatgccaggg caaaccaaaa 540
cttcgttaat aggaggtgcg ccgtatcccc cgtcaacgga atttttgaac gggtatacat 600
aactgtgttt aaagtggttc tagtcacggt ttccataagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt cagatcggcc acttctttta aaatttccag 720
aagacgagat tcggagacag gtgttaagcc tcctagttcc gtgcacagcc gttttagatg 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaacaatcg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcgtcaa gacaaagatc 900
atccacagaa aaacactgca aatgttgata cgaaaaaatt tgcttacatg tattacataa 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc agcgtataat catagtcact 1020
tgaaagataa ttgcacgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 65
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 65
ttagtctata actacaattt ctggatgggc tgtaaaatac tcttcggctc gttttagatt 60
ttttgacgta tatgtcttta gcatatcata tattgcctgg ggttcggtta tatttaatac 120
caagctcgca tcacggctga aaagctgttt tactaaaaaa atgttgctca agttatacat 180
ataaactcta tgcgcaatga gtcgcgctct atcaaagtta gtagccccca aatcaataca 240
gaaaaatagg tttaaagtat tattgttata gatagataga ttcatgccat aatcgggact 300
agcccccaac atatgacagt aataaatggc tgcataattt tcttcccgca ggcaagcaaa 360
tttcatcatt agattagggc taatgcaaat ctctttttta gaacacagct catgcaagtc 420
aaaaatatta ttaaaataaa ggctacaagc cagccgccaa tagagctgat ttttatgctt 480
ttcatagaaa tagtgaatcg cttttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
cttcgttaat aggaggtgcg ccgtatcccc cgtcaacgga atttttgaac gggtgtacat 600
aacggtgttt aaagtggttc tagtcacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt cagatcggcc acttctttta aaatttccag 720
aagacgagat tcggagacag gtgttaagcc tcctagttct gtgcacagcc gttttagatc 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaacaatcg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcgtcaa gacaaagatc 900
atcctcagaa aaacactgca aatgttgata cgaaaaaatt tgcttacatg tattacataa 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc agcgtataat catagtcact 1020
tgaaagataa ttgcatgcca caaccttttt ggccaacgtt tgtaaagaca acat 1074
<210> 66
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 66
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcatatt 60
ttttgaagta tatgtcttta gcatatcata tatttcctgg ggttcggtta catctaatac 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatga gttgtgccct atcaaaatcg gcggccccca aatcaataca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccccaac ctatgacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc taatgcaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagagctgat ttttatgcct 480
tttataaaaa tagtggatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggaggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt taggttggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgtcaagcc tcccagttcc gcacacagcc gctttagata 780
cacggcagga acacgtataa gcccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagttca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaact tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 67
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 67
ttagtctata actacaattt ctggatgggc tgtaaaatac tcttcggctt gttttagatt 60
ttttgacgta tatgtattta gcatatcata tattgcctgg ggctcagtta gatctaatat 120
caagctcaca tcacggctga aaagctgttt tactaaaaaa aggttgctca agttatacat 180
ataaactcta cgcgcaatga gtcgcgccct atcaaagtta gtagccccca aatcaatgca 240
gaaaaatagg tttaaagtat tattgttata gatagataga ttcatgccat aatcaagact 300
agcccctaac atatgacagt aataaatggc tgcataattt tcttcccgca agcaagcaaa 360
tttcatcatc agattagggc taatgcaaat ctctttttta caacacagct catgcaagtc 420
aaaaatgttg ttaaaataaa ggctacaagt cagtcgccaa tagagctgat ttttatgctt 480
ttcgtagaaa tagtgaatag cttttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgataat aggaggtgcg ccgtatcccc cgtcaacgga atttttgaac gggtgtacat 600
aactgtgtct aaggtggttc tagtcacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt cagatcggcc acttctttta aaatctccag 720
aagacgagat tcggatacag gtgttaagcc tcctagttcc atgcacagcc gctttagatg 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaacaatcg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata tgaaaaaatt tgcttacatg tattacataa 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc agcgtataat cataatcact 1020
tgaaagataa ttgcatgcca caactttttt ggccagcgtt tgtaaagaca acat 1074
<210> 68
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 68
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggccc gtttcatatt 60
ttttgaagta tatgtcttta gcatatcata tatttcctgg ggttcggtta catctaatac 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatga gttgtgccct atcaaaatcg gcagccccca aatcaataca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccccaac ctatgacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc taatgcaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagagctgat ttttatgcct 480
tttataaaaa tagtggatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggaggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt taggttggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgttaagcc tcccagttcc gcacacagcc gctttagata 780
cacggcagga acacgtataa gcccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagttca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaact tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 69
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 69
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcagatt 60
ttttgaagta tatgacttta gcctatcata tatttcctgg ggttcggtta catctaatgc 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatgt gttgtgccct atcaaaatca gtagccccca aatcgatgca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccctaac ctataacagt aataaatggc cgcataattt tttttctgca agcaagcaaa 360
tttcatcatc agattagggc tgatgcaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttatagaaa tagtgaatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggaggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt tagcttggcc acttctttta aaatttccag 720
aagacggggt tcggttacag gcgttaagcc tcccagttcc gtgcacagcc gctttagatg 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaatt tgcttacaat tgttacacag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caaccttttt ggccaacgtt tgtaaagaca acat 1074
<210> 70
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 70
ttagtctata actataattt ctggatgggc tgtaagatac tcttcagctc gtttcagatt 60
ttttgaagta tatgacttta gcatatcata tatttcctgg ggttcggtta catctaatgc 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatgc gttgtgccct atcaaaatca gtagccccca aatcgatgca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccctaac ctataacagt aataaatggc cgcataattt tttttctgca agcaagcaaa 360
tttcatcatc agattagggc tgatgcaaat ctctttttca cgacacaact cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttatagaaa tagtgaatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggtggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagc agaactcctg cacaggattt tagcctggcc acttctttta aaatttccag 720
aagacgggat tcggatacag gcgttaagcc acccagttcc gtgcacagcc gctttagatg 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta catgtttata cgaaaaaatt tgcttacaat tattacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caaccttttt ggccaatgtt tgtaaagaca acat 1074
<210> 71
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 71
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcatatt 60
ttttgaagta tatgccttta gcctatcata tatttcctgg ggttcggtta catctaatgc 120
caaggtcaca tcacggctga aaagctgctt tactaaaaga atgttgctca agttatacat 180
ataagctttg tgcgcaatgc gttgtgccct atcaaaatca gtagccccca aatcgatgca 240
gaaaaacagg tttaaagaat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agctcccaac ctataacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc taatgcaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttatagaaa tagtgaatag cctttgtaaa attatgtcgt aatgccagcg caaaccaaaa 540
ctttgttaat aggtggtgcg ccgtatcccc catcaacgga atttttgaac agctgtacat 600
aactgtgtct aaagtggttc tagttatggt ttccaagagt gggttataac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt taggttggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gtgttaagcc tcccagttct gtgcacagcc gctttagatg 780
cacggtagga acacatataa gtccatattc aggatttgca ccccaatcca caaataaacg 840
tataagctca agattatccc tcttcacggc ctttactagc gccgcttcaa gacagagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaatt tgcttacaat tgttacacag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacatataat catagtcact 1020
tgaaagataa ttgcatgcca caaccttttt ggccaacgtt tgtaaagaca acat 1074
<210> 72
<211> 1074
<212> DNA
<213> 非洲猪瘟病毒
<400> 72
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcagatt 60
ttttgaagta tatgacttta gcatatcata tatttcctgg ggttcggtta catctaatgc 120
caaggtcaca tcacggctga aaagctgctt tactaaaaaa atgttgctca agttatacat 180
ataagttttg tgcgcaatgc gttgtgccct atcaaaatca gtagccccca aatcgatgca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccctaac ctataacagt aataaatggc cgcataattt tttttccgca agcaagcaaa 360
tttcatcatc agattagggc tgatacaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttataaaaa tagtgaatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggtggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt tagcttggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgttaagcc tcccagttcc gtgcacagcc gctttagatg 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaatt tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacatataat catagtcact 1020
tgaaagataa ttgcatgcca caaccttttt ggccaacgtt tgtaaagaca acat 1074
<210> 73
<211> 1596
<212> DNA
<213> 非洲猪瘟病毒
<400> 73
atgttctctc tccagaactt atgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgatt atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgggcaggaa acaactgtgt gcttatacaa caacataccc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtgg gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggta accgctacaa cttaattcgt 300
aaatatgatg atcaaatcaa ggaccatcat gacattctgc cattcattga tgatccaatc 360
atatttcaca aatgccatat catgcggcga tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg tgttcttctt tattttaaat atacattaga ggatgatttg 480
cccctcgttc atttacttat tgaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tgtctgccat ataatagata cctttgactg tgctattgcc 600
cataaagatc tacgtttata ttgtttgggg tatacattta tatacaacag gattgtaccc 660
tataagtatc atcatttaga tattctcata ctttcaagcc tacaactcct acataaggtg 720
gcggccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taatatagat 780
aatttagatg ttattctaac acaagctgca acatataacc atagaaaaat tttaacctat 840
tttattcctc aatcaaccta cgcacaaata gaacaatgtt tgttcgtggc gataaaaaca 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaacctttc catcaaactc 960
atccaaaaaa tcagccaata tgttgccact ttcaattcaa caaatataat aggcattctg 1020
agtatgaagc ggaaaaagaa gatatatttg gatatcatat tgacaaaatt tgtaaaaaat 1080
gctattttta ataaatttgt cgttcgatgt atggagagat tttctataaa cccggaaaga 1140
atcgtcaaaa tggctgcgcg tataaataag atgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggc tagacttaaa caccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg aacactgcta ttaccatatg 1320
caaggggaag aaatttttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
ttcgacgttt tttataattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ctaatatcaa catcgtgaac 1500
aagtatattg gcaacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattatatg ccttag 1596
<210> 74
<211> 1596
<212> DNA
<213> 非洲猪瘟病毒
<400> 74
atgttctctc tccagaactt atgtcgaaaa acattaccta accgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatacag caacataccc tcattcccgt aaatgaagcc 180
ctgagaacag cagcatctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagtc 360
atatttcaca aatgccatat catgcggcaa tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tactttaaac atagattaga ggatgatttg 480
cccttcactc atttacttat tgaaaaggca tgtaaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tatctacaat atgatagata cctttgaatg tgctattgcc 600
cataaggatc tacatctata ttgtttgggg tatagattta tatataacag aatcgtaccc 660
gataagtatc atcatttaga tattcgcatg ctttcaagcc tacaactcct acataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taataaagat 780
aatataaata ttattctaac acaagctgca acctataacc atagaaaaat tttaatctat 840
ttcattcctc aatcaaccca cgcacagata gaacaatgtt tactagtggc gataaaagca 900
aaatcttcca ggaaaacctt gaacttacta ctgtctcacc taaacctttc catcaacctc 960
atcaaaaaaa taagccatta tgttgccact tacaattcaa caaatataat aggcattctg 1020
agtatgcggc ggaaaaagaa gatatattta gatatcatat tgacaaaatt tgtaaaaaaa 1080
gctattttta ataagtttgt cgttcgatgt atggatacat tttctataaa cccggaaaga 1140
atccttaaaa tagccgcgcg aataaatagg atgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggt tagacttaaa taccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg atcgctgtta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ccaatatcaa catcgtgaac 1500
aagtatatcg gcaacctgtt tgttatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tttattctaa acaatacatg ccttag 1596
<210> 75
<211> 1596
<212> DNA
<213> 非洲猪瘟病毒
<400> 75
atgttctctc tccagaactt atgtcgaaaa acattaccta accgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatacag caacataccc tcattcccgt aaatgaagcc 180
ctgagaacag cagcatctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagtc 360
atatttcaca aatgccatat catgcggcaa tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tactttaaac atagattaga ggatgatttg 480
cccttcactc atttacttat tgaaaaggca tgtaaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tatctacaat atgatagata cctttgaatg tgctattgcc 600
cataaggatc tacatctata ttgtttgggg tatagattta tatataacag aatcgtaccc 660
gataagtatc atcatttaga tattcgcatg ctttcaagcc tacaactcct acataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taataaagat 780
aatataaata ttattctaac acaagctgca acctataacc atagaaaaat tttaatctat 840
ttcattcctc aatcaaccca cgcacagata gaacaatgtt tactagtggc gataaaagca 900
aaatcttcca ggaaaacctt gaacttacta ctgtctcacc taaacctttc catcaacctc 960
atcaaaaaaa taagccatta tgttgccact tacaattcaa caaatataat aggcattctg 1020
agtatgcggc ggaaaaagaa gatatattta gatatcatat tgacaaaatt tgtaaaaaaa 1080
gctattttta ataagtttgt cgttcgatgt atggatacat tttctataaa cccggaaaga 1140
atccttaaaa tagccgcgcg aataaatagg atgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggt tagacttaaa taccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg atcgctgtta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ccaatatcaa catcgtgaac 1500
aagtatatcg gcaacctgtt tgttatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tttattctaa acaatacatg ccttag 1596
<210> 76
<211> 1593
<212> DNA
<213> 非洲猪瘟病毒
<400> 76
atgttctctc tccaaaactt atgtcgaaaa accttacctg actgtaaact tcctgaattt 60
tttgacgatt atgtattaca actgctggga ttatactggg aaaaccatgg aacgattcaa 120
cgagcaggaa acaactgtgt acttatccaa caacataacc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggta accgccacaa cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc catttattga cgatccagtt 360
atatttcaca aatgtcatat aatgcggcga tgctttttta attgtatgtt gtatcaagct 420
gtaaaatata gtaagtttag cgttcttcta tattttaaat atatattaaa ggaaaatttg 480
cccctcgtcc actcactcat tgaaaaagcg tataaatatc ataattatga ggttattaaa 540
tggatctatg aaaatctaca tatctatgat atcataaata cttttaaata tgctattgcc 600
cataaagatc tacgtttata ttgtttaggg tatacatttg tatataatag gatcgtaccc 660
tataagtatt atcatttaga tattcgcatc cttttaaggc tacaacttct acataaggtg 720
acagccaaag gatacttgga ttttatccta gaaaccttaa agtatgatca taatacaaac 780
aatatagata ttatcctaac acaggctgca acctataacc atagaaacat tttaacctat 840
ttcattcctc aatcaaccta cgcacaaata gaacaatgct tattcgtggc aataaaaaca 900
aacgcttcca aaaaaacctt gaatttacta ttatctcacc taaacctttc tatcaaactc 960
gtcaaaaaat taagccaata tgttgtcgct tacaagtcaa caaatatcat aagcattctg 1020
agtatgcagc aaaaaaagaa gatatattta gatatcattt tgacaaaggt tgtaaaaaac 1080
gctgttttta ttaaatttgt cattggatgt atggttacat tttccataaa cccagaaaga 1140
attgtcaaaa tggccgcgcg aataaaaaag atgaagttag taaaaaatat atctgaacat 1200
gtttggaaaa atcatgcggc taaacttaaa catcttaagc atgcggtaca cacgatgaag 1260
catcaagaag gaaaaaatag actcatgaac tttatctatg atcactgcta ttaccacatg 1320
caaggagaag agatctttag tcttgcaaga ttttatgcaa tccatcatgc gccaaaattg 1380
ttcgacgttt tttatgattg ttgtatccta gatacgatac gatttaaaag cctgctttta 1440
gattgttcac atattatagc taaaaacgct catgatgcta gtattaacat cgtgaataag 1500
tatattggca atctatttgc tatgggagtt cttagcaaaa aagaaatctt acaagactat 1560
ccatccatct attctaaata tgacatactt tag 1593
<210> 77
<211> 1593
<212> DNA
<213> 非洲猪瘟病毒
<400> 77
atgttctctc tccagaactt atgtcgaaaa accttacctg actgtaaact tcctgagttt 60
tttgacgatt atgtattaca actgctgggc ttatactggg aaaatcatgg tacgattcaa 120
cgagcaggaa acaactgtgt acttatccaa caacataacc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga ggaaaattat gagatcgtga gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggga accaccacaa cttaattcgt 300
aaatacgatg accaaatcaa ggaccatcat gaaattctgc catttattga cgatccagtc 360
atatttcaca aatgtcatac aatgcggcga tgctttttta attgtatttt atatcaagct 420
gtaaaatata gtaagttcag cgttcttcta tactttaaat atatattaaa ggagaatttg 480
cccctcgtcc actcacttat tgaaaaggcg tataaatatc ataattatga ggttattaaa 540
tggatctatg aaaacctaca tatctatgat atcataaata cttttaaatg tgctattgcc 600
cataaagatc tacgtttata ttgtttaggg tatacatttg tatataatag aatcgtaccc 660
tataagtatt atcatttaga tattcgcatc cttttaaggc tacaacttct acataaggtg 720
acagccaaag gatacttgga ttttatccta gaaaccttaa agtatgatca taatacaaac 780
aatatagata ttatcctaac acaggctgca acctataacc atagaaacat tttaacctat 840
ttcattcctc aatcaaccta cgcacaaata gaacaatgtt tattcgtggc gataaaaaca 900
aatgcttcca agaaaacctt gaatttacta ttatctcacc taaatctttc tatcaaactc 960
gtcaaaaaat taagccaata tgttgtcgct tacaagtcaa caaatatcat aagcattctg 1020
agtaggcagc aaaaaaagaa gatatattta gatatcattt tgacaaaggt tgtaaaaaat 1080
gctgttttta ataaatttgt cattggatgt atggttacat tttccataaa cccagaaaga 1140
attgtcaaaa tggccgcgcg aataaaaaag atgaagttag taaaaaatat atctgaacat 1200
gtttggaaaa atcatgcggt taaacttaaa tatcttaagc atgcggtaca cacgatgaag 1260
catcaagaag gaaaaaatag attaatgaac tttatctatg atcactgtta ttaccacatg 1320
caagaagaag agatctttag cctcgcaaga ttttatgcaa tccatcatgc gccaaaattg 1380
ttcgacgttt tttatgattg ttgtatccta gatacgatac gatttaaaag cctgctttta 1440
gattgttcac atatcatagt taaaaacgct catgatgcta gtattaacat cgtgaacaag 1500
tatattggca atctatttgc tatgggagtt cttagcaaaa aagaaatctt acaagactat 1560
ccatctatct attctaagga ttacatgctt tag 1593
<210> 78
<211> 1593
<212> DNA
<213> 非洲猪瘟病毒
<400> 78
atgttttctc tccagaactt atgtcgaaaa accttacctg accgtaaact tcctgaattt 60
tttgacgatt atgtattaca actgctggga ttatactggg aaaaccatgg aacgattcaa 120
cgagcaggaa acaactgtgt acttatccaa caacataacc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtga gccttttatt agcttgggag 240
gggaaccttt actatgctat tataggggct ctagagggta atcgccacaa cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc catttattga cgatccagtc 360
atatttcaca aatgtcatat gatgcggcga tgctttttta attgtatttt gtatcaagct 420
gtaaaatata gtaagtttag cgttcttcta tattttaaat atatattaaa ggagaatttg 480
cccctcgttc attcacttat tgaaaaggcg tgtgaagatc ataattatga agttattaaa 540
tggatctatg aaaacctaca tatctatgaa ataatggata cctttaaatg tgctattgcc 600
cataaagatc tacatttata tagtttagga tatacattta tatataatag gatcgtaccc 660
tataagtatc atcatttaga tattcgcata ctttcaaggc tacaacttct acataaggtg 720
acagccaaag gatacttgga ctttatccta gaaaccttaa agtatgatca taataaagat 780
aatataaata ttattctgac acaagctgca acctataacc atagaaacat tttaacctat 840
ttcattcctc aatcaaccta cgcgcagata gaacaatgct tattcgtggc aataaaaaca 900
aacgcttcca agaaaacctt gaatttacta ttatctcacc taaacctttc tatcaaactc 960
gtcaaaaaat taagccaata tgttgttgct tacaagtcaa caaatatcat aagcattctg 1020
agtatgcagc aaaaaaagaa gatatattta gatatcattt tgacaaaggt tgtaaaaaac 1080
gctattttta ttaaatttgt cattggatgt atggttacat tttccataaa cccagaaaga 1140
attgtcaaaa tggccgcgcg aataaaaaag atgaagttag tgaaaaatat atctgaacat 1200
gtttggaaaa atcatgcggc taaacttaaa caccttaagc atgcggtaca cacgatgaag 1260
catcaagaag gaaaaaatag attaatgaac tttatctatg atcactgtta ttaccacatg 1320
caaggagaag agatctttag tcttgcaaga ttttatgcaa tccatcatgc gccaaaattg 1380
ttcgacgttt tttatgattg ttgtatccta gatacgatac gatttaaaag cctgctttta 1440
gattgttcat atatcatagc taaaaacgct catgatgcta gtattaacat cgtgaataag 1500
tatattggca atctatttgc tatgggggtt cttagcaaaa aagaaatctt acaagactat 1560
ccatccatct attctaagga ttacatgctt tag 1593
<210> 79
<211> 1596
<212> DNA
<213> 非洲猪瘟病毒
<400> 79
atgttctctc tccagaactt atgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgatt atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgggcaggaa acaactgtgt gcttatacaa caacataccc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtgg gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggta accgctacaa cttaattcgt 300
aaatatgatg atcaaatcaa ggaccatcat gacattctgc cattcattga tgatccaatc 360
atatttcaca aatgccatat catgcggcga tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg tgttcttctt tattttaaat atacattaga ggatgatttg 480
cccctcgttc atttacttat tgaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tgtctgccat ataatagata cctttgactg tgctattgcc 600
cataaagatc tacgtttata ttgtttgggg tatacattta tatacaacag gattgtaccc 660
tataagtatc atcatttaga tattctcata ctttcaagcc tacaactcct acataaggtg 720
gcggccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taatatagat 780
aatttagatg ttattctaac acaagctgca acatataacc atagaaaaat tttaacctat 840
tttattcctc aatcaaccta cgcacaaata gaacaatgtt tgttcgtggc gataaaaaca 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaacctttc catcaaactc 960
atccaaaaaa tcagccaata tgttgccact ttcaattcaa caaatataat aggcattctg 1020
agtatgaagc ggaaaaagaa gatatatttg gatatcatat tgacaaaatt tgtaaaaaat 1080
gctattttta ataaatttgt cgttcgatgt atggagagat tttctataaa cccggaaaga 1140
atcgtcaaaa tggctgcgcg tataaataag atgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggc tagacttaaa caccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg aacactgcta ttaccatatg 1320
caaggggaag aaatttttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
ttcgacgttt tttataattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ctaatatcaa catcgtgaac 1500
aagtatattg gcaacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattatatg ccttag 1596
<210> 80
<211> 1593
<212> DNA
<213> 非洲猪瘟病毒
<400> 80
atgttctctc tccagaactt atgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatccag caacataacc ttattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
ggaaaccttt actatgctat tataggggct ctagagggca accgccccga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattttgc cattcatcga cgatccaatc 360
atatttcaca aatgtcacat aatgcggcga tgctttttta attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg tgttcttctt tattttaaac ataggttagg ggatgatttg 480
cccctcactc atttacttat tgaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggatctatg aaaacctaca tagctacaat ataatggata cctttgaatg tgctattgcc 600
cataaggatc tacgtctata ttgtttgggg tatacattta tatataatag gatcgtaccc 660
tataagtatc atcatttaga tatttgcata ctttcaagcc tacaactcct gcataaggtg 720
gcagccaaag gatacttgga ttttatccta gaaaccttaa agtatgatca taacataaat 780
aatatagata ttattctaac acaagctgca acctataacc atagaaaaat tttaacctat 840
ttcattcctc aattaaccta cgcacagata gaacaatgtt tactagtggc gataaaaaca 900
aaagcttcca agaaaacctt gaacttacta ctgtctcacc taaacctttc catcaaactc 960
atcaaaaaaa taagccaata tgttgtcact tacaattcaa caaatatcat aagcattctg 1020
agtatgcggc ggaaaaagaa gatatattta gatatcattt tgacagagtt tgtaaaaaac 1080
gctattttta ataaatttgt cgttcgatgt atggatacat tttccataaa cccggaaaga 1140
attgtcaaaa tggccgcacg aataaatagg atgatgttag tgaaaaatat atctgaacgt 1200
gtttggaaaa atcatgcggt taaacttaaa caccttaagc atgcggtaca tacgatgaag 1260
catcaagaag gaaaaaatag actcatgaac tttatctatg atcactgcta ttaccacatg 1320
caaggggaag agatctttgg cctcgcaaga ttttatgcaa tccatcatgc acccaagttg 1380
tttgacgttt tttatgattg ctgcatgcta gatgctacac gatttaaaag cctgctttta 1440
gattgtccac atatcatagg taaaaacgct tatgatgctg gtatcaacct cgtgaacaaa 1500
tatattggca acctatttgc tatgggggtt cttagcaaaa aagaaatctt acaggactat 1560
ccatctatct attctaaaca tgatatgttt tag 1593
<210> 81
<211> 1596
<212> DNA
<213> 非洲猪瘟病毒
<400> 81
atgttctctc tccagaactt atgtcgaaaa acattacctg attgtaaact tcctgaattt 60
tttgacgatt atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgggcaggaa acaactgtgt gcttatacag caacataccc ttattcccat aaatgaagcc 180
ctgagaacag cagcatctga agaaaattat gagatcgtga gccttttatt agcatgggag 240
gggaatcttt actatgctat tataggggct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagta 360
atatttcaca aatgccatat catgcggcga tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tattttaaat ataggttaga ggatgattta 480
cccctcactc atttacttat tgaaaaggca tgtgaaaatc ataattatga agttattaga 540
tggatatatg aaaacctaca tatctacaat atgatagata cctttgaatg tgctattgcc 600
cataaggatc tacgtctata ttgtttgggg tatacattta tatataacag gatcgtaccc 660
aataagtatc atcatataga tattctcatt ctttcaagcc tacaactcct gcataaggtg 720
gcagccaaag gatacttaga ctttatccta gaaaccttaa agtatgatca taacaatgat 780
aatttagata ttattctaac acaagctgca acatataacc atagaaaaat tttaacctat 840
tttattcctc aatcaaccta cgcacaaata gaacaatgtt tgatggtggc gataaaaaca 900
aaatcttcca agaaaacctt gaatttacta ttgtcccacc taaacctttc catcaaactc 960
atcaaaaaaa taagccaata tgttgtcact tacaattcaa caaatataat aggcattctg 1020
agtatgaagc gaaaaaagaa gatatattta gatatcttgt tgacaaaatt tgtaaaaaat 1080
gctattttta ataaatttgt cgttcgatat atggatacgt tttctataaa cccggaaaaa 1140
atcgtcaaaa tggccgcgcg aataaataag atgatgttag tgaaaaaaat atctgaacat 1200
atttggaaaa atcatgcggc tagacttgaa caccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg agtactgcta ttaccatatg 1320
caaggggaag aaatttttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
ttcgacgttt tttataattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ctaatatcaa catcgtgaac 1500
aagtatattg acaacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tttattctaa acattatatg ccttag 1596
<210> 82
<211> 1596
<212> DNA
<213> 非洲猪瘟病毒
<400> 82
atgttctctc tccagaactt atgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttgtacaa caacataccc tcattcccgt aaacgaagcc 180
ctgagaatag cagcgtctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
ggaaaccttt actatgctat tataggagct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga caatccagtc 360
atatttcaca aatgccatat aatgcggcga tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tattttaaat ataggttaga gaatgatttg 480
cccctcgctc atttacttgt tgaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggttatatg aaaacctaca tatctacaat ataatggaga cctttgaatg tgctattgcc 600
cataaggatc tacgtctata tcgtttgggg tatacattta tatataacag gatcgtaccc 660
tataagtatc attatttaga tgttctcatt ctttcaggcc tacatctcct gtataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taacaatgat 780
aatttagata ttattctaac acaagctgta acatataacc atagaaaaat tttaacctat 840
tacattcctc aattaaccta tgcacaaata gaacaatgtt tgttcatggc gattaaaaaa 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaagctttc catcaaactc 960
atcaaaaaaa taagccaata tgttgccact tacaattcaa caaatataat aggcattctg 1020
aatatgaagc ggaaaaagaa gatatattta gatatcatat tgacaaaatt tgtaaaatac 1080
gctattttta ataaatatgt cgttcgttgt atggatacat tttccataaa cccggaaaga 1140
atcatcaaaa tggccgcgcg aataaataag atgttgttag tgaaaaaaat atctcaacat 1200
gcttggaaaa atcatgcggc tagacttaaa caccttaagc atgcggtata cacgatgaaa 1260
cataaagatg ggaaaaatag actcatgaac ttgatctatg atcactacta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtctccta gatactatac gatttaaaag ccttctttta 1440
gattgttcac acatcatagg taaaaacgct catgatgcta ctaatatcac tatcgtgaac 1500
aagtatattg gcaacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattacatg ccttag 1596
<210> 83
<211> 1596
<212> DNA
<213> 非洲猪瘟病毒
<400> 83
atgttctctc ttcagaacct atgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatacag caacataacc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtga gtcttttatt agcatgggag 240
gggaaccttt actatgctat tataggggct ctagagggca accgccacga cttaattcgt 300
aagtatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagta 360
atatttcaca aatgccatat catgcggcaa tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tcttttaaac atagattaag ggatgatttg 480
cccttcactc atttacttat tgaaaaggca tgtaaagatc ataattatga agtaattaaa 540
tggatatatg aaaacctaca tatctacaat atgatagata cctttgaatg tgctattgcc 600
cataaggatc tacgtctata ttgtttgggg tatagattta tatataacag gatcgtaccc 660
gataagtatc atcatttaga tattcgcatg ctttcaagcc tacaactcct gcataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taataaagat 780
aatataaata ttattctaac acaagctgca acctataacc atagaaaaat tttaatctat 840
ttcattcctc aatcaaccca cgcacagata gaacaatgtt tactagtggc gataaaaaca 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaacctttc catcaatctc 960
atcaaaaaaa taagccatta tgttgccact tacaattcaa caaatataat aggcattctg 1020
agtatgcggc ggaaaaagaa gatatattta gatatcatat tgacaaaatt tgtaaaaaaa 1080
gctattttta ataaatttgt cgttcgatgt atggatacat tttctataaa cccggaaaga 1140
atccttaaaa tagccgcgcg aataaatagg acgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggt tagacttaaa taccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg atcgctgtta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ccaatatcaa catcgtgaac 1500
aagtatatcg gcaacctgtt tgttatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattacatg ccttag 1596
<210> 84
<211> 1596
<212> DNA
<213> 非洲猪瘟病毒
<400> 84
atgttctctc tccagaacct atgtcgaaaa actttacctg actgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatacag caacgtaccc tcattcccgt aaatgaagcc 180
ctgagaatag cagcatctga agaaaattat gagatcgtgg gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggagct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagtc 360
atatttcaca aatgccatat aatccgacga tgctttttta attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tactttaaac atagattaga ggatgatttg 480
cccctcactc atttacttat tgaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tacctacgat ataatggata cctttgaatg tgctattgcc 600
cataaggatc tacgtctata ttgtttgggg tatacattta tatataacag gatcgtaccc 660
tatgagtatc atcatttaga tattctcatt ctttcaagcc tacaactcct gcataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taacaatgat 780
aatttagata ttattctaac acaagctgca acatataacc atagaaaaat tttaacctat 840
ttcattcctc aattaaccta cgcacaaata gaacaatgtt tgttcatggc gataaaaaga 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaccctttc catcgaactc 960
atcaaaaaaa taagccaata tgttgtcact tacaattcaa caaatataat aggcattctg 1020
agtatgaagc ggaaaaagaa gatatattta gatatcatgt tgacaaaata tgtaaaatac 1080
gctattttta ataaatatgt cgttcgatgt atggatagat tttccataaa cccggaaaga 1140
atcatcaaaa tggccgcgcg aataaatagg atgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggc tagacttaaa caccttaagc atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg atcgctgcta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtatccta gatactatac aattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ccaatatcaa catcgtgaac 1500
aagtatattg gcgacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattacatg ctttag 1596
<210> 85
<211> 1596
<212> DNA
<213> 非洲猪瘟病毒
<400> 85
atgttttctc tccagaactt gtgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatacag caacataccc tcattcccgt aaacgaagcc 180
ctgagaatag cagcatctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
ggaaaccttt actatgctat tataggagct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagtc 360
atatttcaca aatgccatat catgcggcga tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tattttaaat ataggttaga gaatgatttg 480
cccctcgctc atttacttat taaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tatctacaat ataatggata cctttggatg tgctattgcc 600
cataaggatc tacgtctata tcgtttgggg tatacattta tatataacag gatcgtaccc 660
tataagtatc attatttaga tgttctcatt ctttcaggcc tacatctcct gtataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taacaatgat 780
aatttagata ttattctaac acaagctgca acatataacc atagaaaaat tttaacctat 840
tacattcctc aattaaccta tgcacaaata gaacaatgtt tgttcatggc gattaaaaaa 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaagctttc catcaaactc 960
atcaaaaaaa taagccaata tgttgccact tacaattcaa caaatataat aggcattctg 1020
aatatgcggc ggaaaaagaa gatatattta gatatcatat tgacaaaatt tgtaaaaaaa 1080
gctattttta ataaatttgt cgttcgatgt atggatacat tttccataaa cccggaaaga 1140
atcatcaaaa tggccgcgcg aataaataag atgttgttag tgaaaaaaat atctgaacat 1200
gcttggaaaa atcatgcggc tagacttaaa caccttaagc atgcggtata cacgatgaaa 1260
cataaagatg ggaaaaatag actcatgaac ttgatctatg atcactacta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtctccta gatactatac gatttaaaaa ccttctttta 1440
gattgttcac acatcatagg taaaaacgct catgatgcta ctaatatcac tatcgtgaac 1500
aagtatattg gcaacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattacatg ccttag 1596
<210> 86
<211> 1581
<212> DNA
<213> 非洲猪瘟病毒
<400> 86
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcata 120
ggagacgacc acatactcat acgacgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccctgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcattttatc ttaccattga ttcaagacgc gaatacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat gagagcgtat 480
cttcacgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaga ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaaca tctcgagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggcaacata gataccgtcc tgacccaagc cgtaaagtac 780
aaccatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaag 840
cttttgttgc tggctgttca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtatgag 960
tccaccttgg tgataaagat tttgttaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgtctta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagggaaaaa gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaatg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atattagact gtttagaaat tgttactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct atttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa agtaattcat 1560
tataaaacaa tacaatgtta a 1581
<210> 87
<211> 1581
<212> DNA
<213> 非洲猪瘟病毒
<400> 87
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcata 120
ggagacgacc acatactcat acgacgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccttgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcattttatc ttaccattga ttcaagacgc gaatacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat gagagcgtat 480
cttcacgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaaa ccatacatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaaca tctcaagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggcaacata gataccgtcc tgacccaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaaa 840
cttttgttgc tggccgtgca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactaccgc gctatgtgat agagtacgag 960
tccaccttgg tgataaagat tttattaaaa aaaagagtga acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgtctta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagggaaaaa gtcatgtttt atttagccaa gctctatgtt 1320
gctcaaaacg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atattagact gtttagaaat tattactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct gtttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa agtaattcat 1560
tataaaacaa tacaatgtta a 1581
<210> 88
<211> 1581
<212> DNA
<213> 非洲猪瘟病毒
<400> 88
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcata 120
ggagacgacc acatactcat acgacgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccttgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcattttatc ttaccattga ttcaagacgc gaatacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat gagagcgtat 480
cttcacgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaaa ccatacatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaaca tctcaagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggcaacata gataccgtcc tgacccaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaaa 840
cttttgttgc tggccgtgca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactaccgc gctatgtgat agagtacgag 960
tccaccttgg tgataaagat tttattaaaa aaaagagtga acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgtctta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagggaaaaa gtcatgtttt atttagccaa gctctatgtt 1320
gctcaaaacg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atattagact gtttagaaat tattactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct gtttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa agtaattcat 1560
tataaaacaa tacaatgtta a 1581
<210> 89
<211> 1581
<212> DNA
<213> 非洲猪瘟病毒
<400> 89
atgttttccc ttcaagacca ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacggtt aggactgtac tggggacgtc acggctctct tcaacgaatc 120
ggggacgatc acatactcat acggcgggac ctcatccttt ccaccaacga ggccttaaaa 180
atggcgggag aagaaggaaa caatgaagta gtaaagctct tgttactgtg ggagggaaat 240
cttcattatg ctatcatagg ggctttacag ggtgatcaat atgacctaat ccataagtat 300
gaaaaccaaa tcgaagacta tcatcatatc ttaccattga ttcaagatgc ggaaacgttt 360
gaaaaatgcc acgccttaga acgtttttgt gatgttccat gtctgctaga acatgctaca 420
aaacacaaca tgctccctat tctccaaaaa tatcaagaag agttgtctat aagagtgtat 480
ctacgcgaaa ccctattcga actagcatgc ctatggcaga ggtatgatat tcttaaatgg 540
atagagcaaa ccatgcatgt ttacgatcta aaaattatat ttaatattgc catctccaag 600
agggatctaa gcatgtactc cttaggatat gttctccttt ttgatagagg gaacaccgaa 660
gctaccttgt taacgcaaca cctcgagaag acagcggcca aggggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggtaactta aatatcgtcc tgttccaagc cgtaaaatac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac cccgtaaaaa tattgaaaaa 840
cttttgttgc tggctgtgca ggaaaaagct tctaagaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtacgag 960
tctaccttgg tgataaagat tttattaaaa aaaagagtaa acctaataga cgccgtgttg 1020
gaaaagactg taagatattt ttctgagacg aaagtaaaga ctattatgga tgagctttcg 1080
attaatccgg aaaaagtcat taagatggcc atacagaaaa tgagaacgga tattgtgatc 1140
caaacttctt atatttggga ggatgatcta gaaagactta ttcgtcttaa aaatatggta 1200
tacaccataa agtatgaaca tgggaaaaaa atgttaatga aagttattca cggcatatac 1260
aaaaacttat tacacgatga aaaagaaaaa gtcatgtttc atttagccaa gttctatatt 1320
gctcaaaacg cggccaccca attcagagac atttgtaaag actgttgcaa actggatgtg 1380
gcgcggttta aaccgcggtt taaacaacta attttagact gtttagaaat tgttactaaa 1440
aaatcttgct ttagtattat agaaatttta gaaaaccata ttatttccct atttatgatg 1500
aaagttatca ctgaagatga aaaaaaccta ggtttagaat tattatataa agtaattagt 1560
tacaaaatga tatcatatta a 1581
<210> 90
<211> 1575
<212> DNA
<213> 非洲猪瘟病毒
<400> 90
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacaatt ggggctgtac tgggaaaaac acggctctct tcaacgaata 120
gggaacgatc acatactcat acggcgggat ctcatccttt ctatcaacga ggccttaaaa 180
atagcggcag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattatg ccatcatagg agccttgcag ggtgaccaat atgacctcat ccatacgtac 300
gaaaaccaaa tcgaagacta tcatcatatc ttgccattga ttcaagatgc gaaaacgttt 360
gaaaaatgcc acgccttgga acgtttttgt gatgttccat gcctactaga acatgctaca 420
aaacacaaca tgctccctat tctccaaaaa taccaagaag agctgtttat aagagtgtat 480
ctccgcgaaa ccctatttga actagcatgc ctatggcaga ggtatgatat ccttaaatgg 540
atagagcaaa ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctaa gcatgtactc tttagaatat attctctttt ttaatagagg gaacaccgat 660
gttgcgttag caacgttgct aacgcaacat ctcgagaaga cagcggccaa ggggctcctc 720
cactttgtgc tagaaacgtt aaaatacggc ggtaacataa acatcgtcct ctcccaagcc 780
gtaaaataca atcatagaaa acttttagat tattttctgc gtcaactacc tcgtaaaaat 840
attgaaaaac ttttgttgct ggccgtacag gaaagggctt ctaagaaaac attgaactta 900
ctgttgtctt atttaaacta ctccgtgaaa cgcatcaaaa aactgctgcg ctatgtgata 960
gagcatgagt ccacactggt gataaggatt ttattaaaaa aaagaataaa cctaatagac 1020
gccgtgttgg aaaagactgt aagatatttt tctatgacta aagtgaggac gatcatggat 1080
gagctttcga ttaatccgga aaaagtcatt aaaatggccg tgcagaaaat gagaacggat 1140
atcgtgatcc atacttctta tgtttgggag gatgatctag aaagacttat tcgtcttaaa 1200
aatatgctat acactataaa gtatgagcat ggaaaaaaaa tgctaattaa agtcattcac 1260
ggcatataca aaaacttata cggcgaaaaa gaaaaagtca tgtttaattt ggccaagttc 1320
tatgctgctc aaaacgcggc cacccaattc aaagacactt gtaaagactg ttgcaaactg 1380
gatgtggcgc ggtttaaaca actaatttta gactgtttag acattattac taaaaaaacg 1440
tgcctcagta tcatggaaat cttagaaaat catattattt cgctatttgc tatgaaaatg 1500
atgacggagg atgaaaaaaa cttaggttta gaaatattat ataaagtaat tagttacaaa 1560
atgatatcat attaa 1575
<210> 91
<211> 1575
<212> DNA
<213> 非洲猪瘟病毒
<400> 91
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacaatt ggggctgtac tgggaaaaac acggctctct tcaacgaata 120
gggaacgatc acatactcat acggcgggat ctcatccttt ctatcaacga ggccttaaaa 180
atagcggcag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattatg ccatcatagg agccttgcag ggtgaccaat atgacctcat ccatacgtac 300
gaaaaccaaa tcgaagacta tcatcatatc ttgccattga ttcaagatgc gaaaacgttt 360
gaaaaatgcc acgccttgga acgtttttgt gatgttccat gcctactaga acatgctaca 420
aaacacaaca tgctccctat tctccaaaaa taccaagaag agctgtttat aagagtgtat 480
ctccgcgaaa ccctatttga actagcatgc ctatggcaga ggtatgatat ccttaaatgg 540
atagagcaaa ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctaa gcatgtactc tttagaatat attctctttt ttaatagagg gaacaccgat 660
gttgcgttag caacgttgct aacgcaacat ctcgagaaga cagcggccaa ggggctcctc 720
cactttgtgc tagaaacgtt aaaatacggc ggtaacataa acatcgtcct ctcccaagcc 780
gtaaaataca atcatagaaa acttttagat tattttctgc gtcaactacc tcgtaaaaat 840
attgaaaaac ttttgttgct ggccgtacag gaaagggctt ctaagaaaac attgaactta 900
ctgttgtctt atttaaacta ctccgtgaaa cgcatcaaaa aactgctgcg ctatgtgata 960
gagcatgagt ccacactggt gataaggatt ttattaaaaa aaagaataaa cctaatagac 1020
gccgtgttgg aaaagactgt aagatatttt tctatgacta aagtgaggac gatcatggat 1080
gagctttcga ttaatccgga aaaagtcatt aaaatggccg tgcagaaaat gagaacggat 1140
atcgtgatcc atacttctta tgtttgggag gatgatctag aaagacttat tcgtcttaaa 1200
aatatgctat acactataaa gtatgagcat ggaaaaaaaa tgctaattaa agtcattcac 1260
ggcatataca aaaacttata cggcgaaaaa gaaaaagtca tgtttaattt ggccaagttc 1320
tatgctgctc aaaacgcggc cacccaattc aaagacactt gtaaagactg ttgcaaactg 1380
gatgtggcgc ggtttaaaca actaatttta gactgtttag acattattac taaaaaaacg 1440
tgcctcagta tcatggaaat cttagaaaat catattattt cgctatttgc tatgaaaatg 1500
atgacggagg atgaaaaaaa cttaggttta gaaatattat ataaagtaat tagttacaaa 1560
atgatatcat attaa 1575
<210> 92
<211> 1581
<212> DNA
<213> 非洲猪瘟病毒
<400> 92
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcata 120
ggagacgacc acatactcat acgacgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccctgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcattttatc ttaccattga ttcaagacgc gaatacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat gagagcgtat 480
cttcacgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaga ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaaca tctcgagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggcaacata gataccgtcc tgacccaagc cgtaaagtac 780
aaccatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaag 840
cttttgttgc tggctgttca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtatgag 960
tccaccttgg tgataaagat tttgttaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgtctta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagggaaaaa gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaatg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atattagact gtttagaaat tgttactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct atttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa agtaattcat 1560
tataaaacaa tacaatgtta a 1581
<210> 93
<211> 1581
<212> DNA
<213> 非洲猪瘟病毒
<400> 93
atgttttccc ttcaagatct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacagtt aggactgtac tggaaacgtc acggctctct tcaacgcata 120
ggagacgacc acatactcat acggcgggac ctcatccttt ccaccaacga ggccttaaaa 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg ggagggaaac 240
cttcattatg ccatcatagg ggccttacag ggtgatcaat atgatctgat ccataagtat 300
gaaaaccaaa tcgaagacta tcatcatatc ttgccattga ttcaagatgc gaaaacgttt 360
gaaaaatgcc acgccttaga acgtttttgt gatgttccat gtctgctaga acatgctaca 420
aaacacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat aagagtgtat 480
cttcgcgaaa ccctattcga actagcatgc ctatggcaga ggtatgatgt tcttaaatgg 540
atagagcaaa ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctaa gcatgtactc cttaggatat gttctccttt ttgatagagg aaacatcgaa 660
gctacgttcc taacgcaaca tctcgagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggtaactta aatatcgtcc tgtcccaagc cgtaaaatac 780
aatcatagaa aacttttgga ttattttctg cgtcaactac ctcgtaaaaa tattgaaaaa 840
cttttgttgc tggccgtgca ggaaaaggct tctaaaaaaa cattgaacct actgttgtca 900
cacttaaact actccgtgaa acacatcaaa aaactgctgc gctatgtgat agagtacgag 960
tctaccttgg tgataaaact tttattgaaa aaaagagtaa acctgataga cgccgtgttg 1020
gaaaagaatg taagatattt ttctgcgatt aaagtgagga ctattatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggcc atacagaaaa tgagaacgga tattgtgatt 1140
cagacttctt atatttggga ggatgatcta gaaagactta ttcgtcttaa aaatatggta 1200
tacaccataa agtatgaaca tgggaaaaaa atgttaatta aagttattca cggcatatac 1260
aaaaacttat tatacggcga aaaagaaaaa gtcatgtttc atttagccaa actctatgtt 1320
gctcaaaacg cggccaccca attcagggac atttgtaagg actgttgcaa actggatgtg 1380
gcgcggttta aaccgcggtt taaacaacta attttagact gtttagaaat ggttactaaa 1440
aaatcttgct ttagtattat agaaatctta gaaaactata ttatttccct atttgtgatg 1500
aaagtcatca ctgaagaaga aaaaaaccta tgtttagaac tattatataa agtaattagt 1560
tacaaaacga tataatgtta a 1581
<210> 94
<211> 1581
<212> DNA
<213> 非洲猪瘟病毒
<400> 94
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcata 120
ggagacgacc acatactcat acgacgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccttgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcattttatc ttaccattga ttcaagacgc gaatacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat gagagcgtat 480
cttcacgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaga ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaaca tctcgagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggcaacata gataccgtcc tgacccaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaaa 840
cttttgttgc tggctgttca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtatgag 960
tccaccttgg tgataaagat tttgttaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgaca aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgtttta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagggaaaaa gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaatg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atattagact gtttagaaat tgttactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct atttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa agtaattcat 1560
tataaaacaa tacaatgtta a 1581
<210> 95
<211> 1554
<212> DNA
<213> 非洲猪瘟病毒
<400> 95
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcgta 120
ggagacgacc acatcctcat acggcgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aagaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccatcatagg agccttgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcatcttatc ttaccattga ttcaagatgc gaaaacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaga acatgctaca 420
aaatacaaca tgctccctat tctccaaaca taccaagaag agctgtctat gagagcatat 480
cttcgcgaaa ccctatttga actagcgtgc ctgtggcaga ggtatgatgt ccttaaatgg 540
atagagcaaa ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga cgatgtattc cttaggatat attcttcttt ttgatagaga gaacaccgaa 660
gctacgttgt taacacaaca tctcgagaag acagcggcca aagggctcct ctactttgtg 720
ctagaaacgt taaaatacgg cggtaacata gatatcgtcc tgactcaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaag 840
cttttgttgc tggccgtgca ggaaaaggct tctaaaaaaa cattgaactt actgttgtcc 900
catctaaact actccgtgaa acgtatcaaa aaactgctgc gctatgtgat agagtacgag 960
tccaccttgg tgataaagat tttattaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagcttttg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgactta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacgacga aagagaaaag gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaacg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atgttagact gtttagaaat tgttactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct atttactatg 1500
aaagttatga ctgaagagga aaaaaaccta tgtttagaaa tattatataa gtaa 1554
<210> 96
<211> 1554
<212> DNA
<213> 非洲猪瘟病毒
<400> 96
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcgta 120
ggagacgacc acatactcat acggcgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccttgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcatcttatc ttaccattga ttcaagacgc gaaaacgttt 360
gaaaaatgcc atgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctgt tctccaaaaa taccaagaag agctgtccat gagagcatat 480
ctttgcgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaaa ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaata tctcgagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggtaacata gatattgtcc tgacccaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaag 840
cttttgttgc tggccgtgca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtacgag 960
tccaccttgg tgataaagat tttattaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagcttttg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtatggga ggatgatcta gaacgactta ctcgtcttaa agatatggta 1200
tacaccgtaa agtacgaaca tgggaaaaaa atgttaatta aagtcataca cggcatatac 1260
aaaaacttat tatacggcga aaaagaaaag gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaacg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atgttagact gtttagaaat tgttactaaa 1440
aaatcttgct atagtattct ggaaatctta gaaaaacata tgatttccct atttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa gtaa 1554
<210> 97
<211> 1569
<212> DNA
<213> 非洲猪瘟病毒
<400> 97
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtat tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcgta 120
ggagacgacc acatactcat acggcgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aagaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccatcatagg agccttgcag ggtgatcaat atgacctaat ccataagtat 300
gaaaaccaaa tcggcgactt tcatcttatc ttaccattga ttcaagatgc gaaaacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaca taccaagaag agctgtctat gagagtatat 480
cttcgcgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaaa ccatgcatgt ttacgaccta aaggttatgt ttaatattgc catctccaag 600
agagatctga ctatgtattc cttaggatat attcttcttt ttgatagaga gaacaccgaa 660
gctacgttgc taacgcaaca tctcgagaaa acagcggcca aggggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggtaacata gatatcgtcc tgtcccaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaaa tattgaaaaa 840
cttttgttgc tggctgttca ggaaaaggct tctaaaaaaa cattgaactt actgttgtcc 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtacgag 960
tccaccttgg tgataaagat tttattaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacaga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgactta ctcgtcttaa aaatatggta 1200
tacgccataa agtatgaaca tgggaaaaaa atgttaatga aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagagaaaag gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaacg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta agcaactaac gttaaactgt ttagaaatta ttactaaaaa atcttgctat 1440
agtatcctgg aaatcctaga aaaacatatt atttccctat ttactatgaa agttatgact 1500
gaagaagaaa aaaacctatg tttagaaata ttatataaag taattcatta taatacaata 1560
caatgttaa 1569
<210> 98
<211> 843
<212> DNA
<213> 非洲猪瘟病毒
<400> 98
atgtcctctt cccttcagga actttgtcga aaaaagctgc ctgactgcat acttccagag 60
ttttttgacg actatgtatt gcaactgtta ggactgcact ggcaagatca tggttccctt 120
cagcgtatcg agaagaacca gatacttgtt caacaggaac ccatccatat caatgaagca 180
ctcaaagtag cagcatcgga agggaactat gaaatcgtag agctgttgtt gtcatgggag 240
gcagatcccc gctacgccgt cgtaggagct ctagaaagca aatactatga cctggtttac 300
aaatactatg acctggttaa agactgccat gatatcttgc cgctgattca aaatccggaa 360
acatttgaaa aatgtcatga gttaaacaac ccctgttctc ttaaatgctt attcaagcat 420
gctgtgatac atgacatgct gccgattctt caaaaatata catactttct ggatgggtgg 480
gagtattgca accagatgct gttcgaactg gcatgtagta aaaaaaaata tgagatggtt 540
gtgtggatag agggagttct aggcatcggc aaagttacat ctcttttcac tattgcgatt 600
agcaacagag acctgcacct gtattccctg ggccacttaa tcattcttga gagaatgcag 660
tcctgtggac aagaccccac gtttttacta aatcatttcc tgcgagacgt ttcaataaaa 720
gggcttctcc cttttgtact gaaaaccata gaatatggtg gaagcaagga gatagccata 780
actctggcta aaaaatatca gcataaacat attttgaaat acttcgaaac cgggaaatgc 840
taa 843
<210> 99
<211> 843
<212> DNA
<213> 非洲猪瘟病毒
<400> 99
atgtcctctt ctcttcagga actttgtcga aaaaagctgc ctgactgcat acttccagag 60
ttttttgacg actatgtatt gcaactgtta ggactgcact ggcaagatca tggttccctt 120
cagcgtatcg agaagaacca gatacttgtt caacaggaac ccatccatat caatgaagca 180
ctcaaagtag cagcatcgga agggaactat gaaatcgtag agctgttgtt gtcatgggag 240
gcagatcccc gctacgccgt cgtaggagcc ctagaaagca aatactatga cctggtttac 300
aaatactatg accaagttaa agactgccat gatatcttgc cgctgattca aaatccggaa 360
acattcgaaa gatgtcatga gttaaacagc acctgttcac tgaaatgctt attcaagcat 420
gctgtgataa atgacatgct gccgattctt caaaaatata cagactatct ggataggtgg 480
gagtattgca gccagatgct gttcgaactg gcatgtagta aaaaaaaata tgagatggtt 540
gtgtggatag agggagttct aggcgtcggc aaagttacat ctcttttcac cattgcgatt 600
agcaacagag acctacagct gtattctctg ggctactcaa ttatccttga gaatttgtac 660
tcctgtggac aggaccccaa gtttttacta aatcatttcc tgcgagacgt ttcaataaaa 720
gggcttctac cctttgtaat caaaaccata gaatatggtg gaagcaagga gatagccata 780
actctggcta aaaaatatca gcataaacat attttgaaat acttcgaaac ctgggaaagc 840
tag 843
<210> 100
<211> 843
<212> DNA
<213> 非洲猪瘟病毒
<400> 100
atgtcctctt ctcttcagga actttgtcga aaaaagctgc ctgactgcat acttccagag 60
ttttttgacg actatgtatt gcaactgtta ggactgcact ggcaagatca tggttccctt 120
cagcgtatcg agaagaacca gatacttgtt caacaggaac ccatccatat caatgaagca 180
ctcaaagtag cagcatcgga agggaactat gaaatcgtag agctgttgtt gtcatgggag 240
gcagatcccc gctacgccgt cgtaggagcc ctagaaagca aatactatga cctggtttac 300
aaatactatg accaagttaa agactgccat gatatcttgc cgctgattca aaatccggaa 360
acattcgaaa gatgtcatga gttaaacagc acctgttcac tgaaatgctt attcaagcat 420
gctgtgataa atgacatgct gccgattctt caaaaatata cagactatct ggataggtgg 480
gagtattgca gccagatgct gttcgaactg gcatgtagta aaaaaaaata tgagatggtt 540
gtgtggatag agggagttct aggcgtcggc aaagttacat ctcttttcac cattgcgatt 600
agcaacagag acctacagct gtattctctg ggctactcaa ttatccttga gaatttgtac 660
tcctgtggac aggaccccaa gtttttacta aatcatttcc tgcgagacgt ttcaataaaa 720
gggcttctac cctttgtaat caaaaccata gaatatggtg gaagcaagga gatagccata 780
actctggcta aaaaatatca gcataaacat attttgaaat acttcgaaac ctgggaaagc 840
tag 843
<210> 101
<211> 849
<212> DNA
<213> 非洲猪瘟病毒
<400> 101
atgtcctctt cccttcagga actttgccga aaaaacttac ccgactacat acttccagag 60
ttctttgacg actatgtgtt gcaactatta ggactacact ggcaagatca tggttctctt 120
caacgtaccg gaaagaatca ggtacttgtt caacaggaac ccattcatat caatgaagca 180
ctaaaagtgg cagcatcaga gggaaacttt gaaatcgtag aactgttgtt gtcatggaag 240
gcagaccccc gctacgctgt cgtaggagcg ctagaaagca aatactatga cctcgtttac 300
aagtattaca acctagttga agaccgccat gatatgttgc cgctgatcca aaattcagaa 360
acgttcgaaa gatgtcatga gttaaacaac tgttctctta aatgcttatt caagcatgct 420
gtaatatatg acaagctgcc gattctacaa aaatatgcag actatttgga cgggtggccg 480
tattgcaacc agatgctgtt cgagttggca tgtaaaaaac aaaaatataa catggttgtg 540
tggatagagg gagtcctggg cgtcggcaac ttcacaattc ttttcacaat tgcgattatc 600
aaaagggacc tacagctgta ttccctgggc tactccatca tccttgagag aatgtattcc 660
tgtggatacg accccacgtt tttactaaat cactatctgc gagtggtttc aacaaaaggg 720
cttctgcctt ttgtactgaa aaccatagaa tatggtggaa gcaaagagat agccttaact 780
ttggctaaaa aatatcagca tgaaactatt ttgagatact tcgaaaccag gaaatcccag 840
gagtgctaa 849
<210> 102
<211> 849
<212> DNA
<213> 非洲猪瘟病毒
<400> 102
atgtcctctt cccttcagga actttgccga aaaaacttac ccgaccacat acttccagag 60
ttctttgacg actatatatt gcaactatta ggactgcact ggcaagatca tggttctctt 120
cagcgtaccg agaagaatca ggtacttgtt caacaggaac ccatccatat caatgaagca 180
ctaaaagtgg cagcatcaga aggaaactac gaaatagtag agctgttgtt gtcatggaag 240
gcagaccccc gatacgctgt cgtaggagcg ctagaaagca aatactatga cctcgtttac 300
aaatattacg accaagttaa agactgccat gatatcttgc cgctgatcca aaattcggaa 360
acattcgaaa gatgtcatga gttgaacaat tgttctctta aatgcttatt caagcatgct 420
gtgatatatg acaagctgcc gattcttcaa aaatatgcaa gctatctgga tgggtggccg 480
tattgcaacc agatgctgtt cgagttggca tgtaaaaaac aaaaatataa catggctgta 540
tggatagagg gagtcctggg cgtcggcaac ttcacaattc ttttcacgat tgcgattatc 600
aaaagagacc tacagctgta ttccctgggc tactcaatga ttcttgagaa aatgtactcc 660
tgtggatacg accctacgtt tttactaaat cattatctgc gaatcgtttc aacaaagggg 720
cttctgccct ttgtgctgaa aaccatagaa tatggtggaa gcaaagagat agccatcact 780
ttggctaaaa agtatcagca tgaaaatatt ttgagatact tcgaaaccag gaaaacccaa 840
gagtgctaa 849
<210> 103
<211> 849
<212> DNA
<213> 非洲猪瘟病毒
<400> 103
atgtcctctt cccttcagga actttgccga aaaaacttac ccgacgacat acttccagag 60
ttctttgacg actatgtgtt gcaactatta ggactacact ggcaagatca tggttctctt 120
caacgtaccg gaaagaatca ggtacttgtt caacaggaac ccattcatat taatgaagca 180
ctaaaagtgg cagcatcaga gggaaacttt gaaatcgtag aactgttgtt gtcatggaag 240
gcagatcccc gctacgctgt cgtaggagcg ctagaaagca aatactatga cctcgtttac 300
aagtattaca acctaattga agaccgccat gatatgttgc cgctgatcca aaattcagaa 360
acgttcgaaa gatgtcatga gttaaacaac tgttctctta aatgcttatt caagcatgct 420
gtgatatatg acaagctgcc gattctacaa aaatatgcag actatttgga cgggtggccg 480
tattgcaacc agatgctgtt cgagttggca tgtaaaaaac aaaaatataa catggttgtg 540
tggatagagg gagtcctggg cgtcggcaac ttcacaattc ttttcacgat tgcgattatc 600
aaaagggacc tacagctgta ttccctgggc tactccatca tccttgagag aatgtactcc 660
tgtggatacg accccacgtt tttactaaat cactatctgc gagtggtttc aacaaaaggg 720
cttctgcctt ttgtactgaa aaccatagaa tatggtggaa gcaaagagat agccatcact 780
ttggctaaaa agtatcagca tgaaactatt ttgagatact tcgaaaccag gaaatcccag 840
gagtgctaa 849
<210> 104
<211> 843
<212> DNA
<213> 非洲猪瘟病毒
<400> 104
atgtcctctt cccttcagga actttgtcga aaaaagctgc ctgactgcat acttccagag 60
ttttttgacg actatgtatt gcaactgtta ggactgcact ggcaagatca tggttccctt 120
cagcgtatcg agaagaacca gatacttgtt caacaggaac ccatccatat caatgaagca 180
ctcaaagtag cagcatcgga agggaactat gaaatcgtag agctgttgtt gtcatgggag 240
gcagatcccc gctacgccgt cgtaggagct ctagaaagca aatactatga cctggtttac 300
aaatactatg acctggttaa agactgccat gatatcttgc cgctgattca aaatccggaa 360
acatttgaaa aatgtcatga gttaaacaac ccctgttctc ttaaatgctt attcaagcat 420
gctgtgatac atgacatgct gccgattctt caaaaatata catactttct ggatgggtgg 480
gagtattgca accagatgct gttcgaactg gcatgtagta aaaaaaaata tgagatggtt 540
gtgtggatag agggagttct aggcatcggc aaagttacat ctcttttcac tattgcgatt 600
agcaacagag acctgcacct gtattccctg ggccacttaa tcattcttga gagaatgcag 660
tcctgtggac aagaccccac gtttttacta aatcatttcc tgcgagacgt ttcaataaaa 720
gggcttctcc cttttgtact gaaaaccata gaatatggtg gaagcaagga gatagccata 780
actctggcta aaaaatatca gcataaacat attttgaaat acttcgaaac cgggaaatgc 840
taa 843
<210> 105
<211> 837
<212> DNA
<213> 非洲猪瘟病毒
<400> 105
atgtcccttc aggaactttg ccgaaaaaac ctgcccgact gcgaacttcc agagttcttt 60
gacgactatg tattgcaact gttaggattg cactggcaag atcatggttc tcttcagcgt 120
accgggaaga atcaggtact tgttcaacag gaacccatcc atatcaatga agcactaaaa 180
agtgcggcat cagaagggaa ctatgaaatc gtagagctgc tgttgtcatg ggaggcagat 240
ccccgctacg ctgtcgtagg agccctagaa agcaattact atgacctggt tcacaaatat 300
tatgaccaag ttaaagactg ccatgatatg ctaccactga tccaaaatcc ggaaatgttc 360
gaaaaatgtc atgagttaaa caacacctgt tctcttaaat gcttattcaa acatgctgtg 420
atacatgaca tgctgccgat tcttcaaaaa tattcagact atttggatgg gtggcagtat 480
tgcaatcaga tactgttcga attggcatgt aaaagacaaa aatataatat ggttgtgtgg 540
atagagggag ttctaggcgt cggcaacttt aaaattcttt tcaccattgc cattaacaac 600
agagatctac agctgtattc tctggggtac ttaatcattc ttgaaagatt gtactcctgt 660
ggacaagacc ccacgttttt actaaaccat ttcctacgag acgtttcaat gaaggggctt 720
ctgccctttg tactgaaaac catagaattt ggtggaagta aggagatagc cataactctg 780
gctaaaaaat atcagcataa acatattttg aagtatttcg aaaccgaaga atgctaa 837
<210> 106
<211> 843
<212> DNA
<213> 非洲猪瘟病毒
<400> 106
atgtcctctt cccttcagga actttgtcga aaaaagctgc ctgactgcat acttccagag 60
ttttttgacg actatgtatt gcaactgtta ggactgcact ggcaagatca tggttccctt 120
cagcgtatcg agaagaacca gatacttgtt caacaggaac ccatccatat caatgaagca 180
ctcaaagtag cagcatcgga agggaactat gaaatcgtag agctgttgtt gtcatgggag 240
gcagatcccc gctacgccgt cgtaggagct ctagaaagca aatactatga cctggtttac 300
aaatactatg accaagttaa agactgccat gatatcttgc cgctgattca aaatccggaa 360
acatttgaaa aatgtcatga gttaaacaac ccctgttctc ttaaatgctt attcaagcat 420
gctgtgatac atgacatgct gccgattctt caaaaatata catactttct ggatgggtgg 480
gagtattgca gccagatgct gttcgaattg gcatgtagta aaaaaaaata cgagatggtt 540
gtgtggatag agggagttct aggcatcggc aaagttacat ctcttttcac tattgcgatt 600
agcaacagag acctgcacct gtattccctg ggccacttaa tcattcttga gagaatgcag 660
tcctgtggac aagaccccaa gtttttacta aatcatttct tgcgagacgt ttcaataaaa 720
gggcttctcc cctttgtact gaaaaccata gaatatggtg gaagcaagga gatagccata 780
actctggcta aaaaatatca gcataaacat attttgaaat acttcgaaac cgggaaatgc 840
taa 843
<210> 107
<211> 309
<212> DNA
<213> 非洲猪瘟病毒
<400> 107
atggttgtgt ggatagaggg agttctaggc atcggcaaag ttacatctct tttcactatt 60
gcgattagca acagagacct gcacctgtat tccctgggcc acttaatcat tcttgagaga 120
atgcagtcct gtggacaaga ccccacgttt ttactaaatc atttcctgcg agacgtttca 180
ataaaagggc ttctcccttt tgtactgaaa accatagaat atggtggaag caaggagata 240
gccataactc tggctaaaaa atatcagcat aaacatattt tgaaatactt cgaaaccggg 300
aaatgctaa 309
<210> 108
<211> 309
<212> DNA
<213> 非洲猪瘟病毒
<400> 108
atggttgtgt ggatagaggg agttctaggc atcggcaaag ttacatctct tttcactatt 60
gcgattagca acagagacct gcacctgtat tccctgggcc acttaatcat tcttgagaga 120
atgcagtcct gtggacaaga ccccacgttt ttactaaatc atttcctgcg agacgtttca 180
ataaaagggc ttctcccttt tgtactgaaa accatagaat atggtggaag caaggagata 240
gccataactc tggctaaaaa atatcagcat aaacatattt tgaaatactt cgaaaccggg 300
aaatgctaa 309
<210> 109
<211> 843
<212> DNA
<213> 非洲猪瘟病毒
<400> 109
atgtcttctt cccttcagga actttgtcga aaaaagctgc ctgactgcat acttccagag 60
ttttttgacg actatgtatt gcaactgtta ggactgcact ggcaagatca tggttctctt 120
cagcgtatcg agaagaacca gatacttgtt caacaggaac ccatccatat caatgaagca 180
ctcaaagtag cagcatcgga agggaactat gaaatcgtag agctgttgtt gtcatgggag 240
gcagatcccc gctacgccgt cgtaggagct ctcgaaagca aatactatga cctggttcac 300
aaatactatg gccaagttaa agactgccat gatatcttgc cgctgattca aaatccggaa 360
acattcgaaa aatgtcatga gttaaacagc acctgttcac tgaaatgctt attcaagcat 420
gctgtgatga atgacatgct gccgattctt gaaaaatata cagactatct ggataggtgg 480
gagtattgca gccagatgct gttcgaattg gcatgcagaa aaaaaaaata tgagatggtt 540
gtgtggatag agggagttct atgcgtcggc aaagttacgt ctcttttcac cattgcgatt 600
agcaacagag acctacagct gtattctctg ggctactcaa ttattcttga gaaaatgtac 660
tcctgtcgac aggaccccac gtttttacta aatcatttcc tgcgagacgt ttcgataaag 720
gggcttctgc cctttgtact gaaaaccata gaatatggtg gaagcaagga gatagccata 780
actctggcta aaaaatatca gcataaacat attttgaaat acttcgaaac ctgggaaagc 840
tag 843
<210> 110
<211> 846
<212> DNA
<213> 非洲猪瘟病毒
<400> 110
atgtcctctt cctcccttca ggaactttgc cgaaaaaagc tgcctgactg catccttcca 60
gagtttttcg acgactatgt attgcaactg ttaggactgc actggcaaga tcatggttct 120
cttcagcgta tcgagaagaa ccagatactt gttcaacagg aacccatcca tatcaatgaa 180
gcactcaaag tagcagcatc ggaagggaac tatgaaatcg tagagctgtt gttgtcatgg 240
gaggcagatc cccgctacgc cgtcgtagga gctctcgaaa gcaaatacta tgacctggtt 300
cacaaatact atgaccaagt taaagactgc catgatatct tgccgctgat tcaaaatccg 360
gaaacattcg aaaagtgtca tgagttaaac agcacctgtt cactgaaatg cttattcaag 420
catgctgtga taaatgacat gctgccgatt cttcaaaaat atacagacta tctggatagg 480
tgggagtatt gtagccagat gctgttcgaa ttggcatgta gaaaaaaaaa gtatgagatg 540
gttgtgtgga tagagggagc tctgggcgtc ggcaaagtta catctctttt caccattgcg 600
attagcaaca gagacctgca gctgtattct ctgggctact caatgattct tgagaaattg 660
tactcctgtg gacaggaccc cacgttttta ctaaatcatt tcctgcgaga cgtttcgata 720
aaggggcttc tgccctttgt actcaaaacc atagaatatg gtggaagcaa ggagatagcc 780
ataactctgg ctaaaaaata tcagcataaa catattttga aatacttcga aacttgggaa 840
agctag 846
<210> 111
<211> 843
<212> DNA
<213> 非洲猪瘟病毒
<400> 111
atgtcctctt cccttcagga actttgtcga aaaaagctgc ctgactgcat acttccagag 60
tttttcgacg actatgtatt gcaactgtta ggactgcact ggcaagatca tggttctctt 120
cagcgtatcg agaagaacca gatacttgtt caacaggaac ccatccatat caatgaagca 180
ctcaaagtag cagcatcgga agggaactat gaaatcgtag agctgttgtt gtcatgggag 240
gcagatcccc gctacgccgt cgtaggagct ctcgaaagca aatactatga cctggttcac 300
aaatactatg gccaagttaa agactgccat gatatcttgc cgctgattca aaatccggaa 360
acattcgaaa aatgtcatga gttaaacagc acctgttcac tgaaatgctt attcaagcat 420
gctgtgatga atgacatgct gccgattctt gaaaaatata cagactatct ggataggtgg 480
gagtattgca gccagatgct gttcgaattg gcatgtagaa aaaaaaaata tgagatggtt 540
gtgtggatag agggagttct aggcatcggc aaagttacgc ctcttttcac cattgcgatt 600
agcaacagag acctacagct gtattctctg ggctactcaa ttattcttga gagaatgtat 660
tcctgtgaac aggatcccac gtttttacta aatcatttcc tgcgagacgt ttcgataaag 720
gggcttctgc cctttgtact gaaaaccata gaatatggtg gaagcaaaga gatagccata 780
actctggcta aaaaatatca gcataaacat attttgaaat acttcgaaac atgggaaagc 840
taa 843
<210> 112
<211> 843
<212> DNA
<213> 非洲猪瘟病毒
<400> 112
atgtcctctt cccttcagga actttgccga aaaaagctgc ctgactgcat acttccagag 60
tttttcgacg actatgtatt gcaactgtta ggattgcatt ggcaagatca tggttctctt 120
cagcgtatcg agaagaacca gatacttgtt caacaggaac ccatccatat caatgaagca 180
ctcaaagtag cagcatcgga agggaactat gaaatcgtag agctgttgtt gtcatgggag 240
gcagatcccc gctacgccgt cgtaggagct ctcgaaagca aatactatga cctggttcac 300
aaatactatg gccaagttaa agactgccat gatatcttgc cgctgattca aaatccggaa 360
acatttgaaa agtgtcatga gttaaacagc acctgttcac tgaaatgctt attcaagcat 420
gctgtgatga atgacatgct gccgattctt gaaaaatata cagactatct ggataggtgg 480
gagtattgca gccagatgct gttcgaattg gcatgtagaa aaaaaaaata tgagatggtt 540
gtgtggatag agggagttct aggcgtcggc aaagttacgt ctcttttcac cattgcgatt 600
agcaacagag acctacagct gtattctctg ggcttctcaa ttattcttga gaaattgtac 660
tcctgtggac aggaccccac gtttttacta aatcatttcc tgcgagacgt ttcgataaag 720
gggcttctgc cctttgtact caaaaccata gaatatggtg gaagcaagga gatagccata 780
actctggcta aaaaatatca gcataaacat attttgaaat acttcgaaac ctgggaaagc 840
tag 843
<210> 113
<211> 350
<212> PRT
<213> 非洲猪瘟病毒
<400> 113
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Tyr Tyr Asp Leu Trp
20 25 30
Trp Tyr Asn Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ser Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Ser Leu Ile Lys Leu Phe Thr Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Arg Asp Leu Cys Gln Glu Leu Gly Ala Lys Glu Ile Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Leu Lys Leu Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Leu Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Val Arg Tyr Ser Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Met Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Met Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Thr Thr Ile Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Phe Ser Lys Asn Met Met Ile Phe Leu Ser Tyr Asp Leu Arg
340 345 350
<210> 114
<211> 350
<212> PRT
<213> 非洲猪瘟病毒
<400> 114
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asn Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Val Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Ser Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 115
<211> 351
<212> PRT
<213> 非洲猪瘟病毒
<400> 115
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Arg Gln
1 5 10 15
Cys Leu Pro Glu Asp Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp Asn Asn Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Leu Ala Gly Ile Gln Glu Gly Leu Asp Leu Asn Met Ala Leu Val Lys
50 55 60
Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu Phe Thr Glu Trp
65 70 75 80
Gly Ala Asn Ile Asn Tyr Gly Leu Ile Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Lys Thr Leu Asn Glu Gly
100 105 110
Asp Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe Tyr Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asp Asn Leu Leu Leu Lys
130 135 140
Arg Val Asn Asn Leu Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Ile Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Asn
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Val Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile Cys Met Asp Leu Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Ile Tyr Tyr Cys
245 250 255
Tyr Met Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Ile Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Ala Phe Glu Glu Gly Met Ala Leu Val Gly Gln Glu Gly Tyr Glu Pro
290 295 300
Ile Arg Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro
305 310 315 320
Leu Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn
325 330 335
Tyr Phe Ser Lys Asn Met Met Val Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 116
<211> 351
<212> PRT
<213> 非洲猪瘟病毒
<400> 116
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Leu Pro Glu Asp Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp Asn Asn Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ala Gly Leu Gln Glu Gly Leu Asp Leu Asn Met Ala Leu Val Lys
50 55 60
Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu Phe Thr Glu Trp
65 70 75 80
Gly Ala Asn Ile Asn Tyr Gly Leu Ile Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Lys Thr Leu Asn Glu Gly
100 105 110
Asp Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asp Asn Leu Leu Leu Lys
130 135 140
Lys Val Asn Asn Leu Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Ile Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Asn
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Val Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile Cys Met Asp Leu Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Ser Leu Ser Thr Ile Tyr Tyr Cys
245 250 255
Tyr Met Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Ile Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Ala Phe Glu Glu Gly Met Ala Leu Val Gly Gln Glu Gly Tyr Glu Pro
290 295 300
Ile Arg Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro
305 310 315 320
Leu Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Glu Leu Lys Asn
325 330 335
Tyr Phe Ser Lys Asn Met Met Val Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 117
<211> 350
<212> PRT
<213> 非洲猪瘟病毒
<400> 117
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Tyr Tyr Asp Leu Trp
20 25 30
Trp Tyr Asn Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ser Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Ser Leu Ile Lys Leu Phe Thr Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Arg Asp Leu Cys Gln Glu Leu Gly Ala Lys Glu Ile Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Leu Lys Leu Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Leu Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Val Arg Tyr Ser Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Met Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Thr Thr Ile Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Phe Ser Lys Asn Met Met Ile Phe Leu Ser Tyr Asp Leu Arg
340 345 350
<210> 118
<211> 349
<212> PRT
<213> 非洲猪瘟病毒
<400> 118
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Leu Pro Thr Asp Gln Tyr Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp Tyr Asp Ser Pro Ile Thr Phe Asp His Asn Leu Gly Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Asp Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Thr Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Arg Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Arg Ile Phe Ile Asp Leu Lys Phe Tyr Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Leu Leu Gln
130 135 140
Lys Val Asn Asn Leu Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Lys Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Asn
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Val Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile Tyr Met Asp Leu Glu Glu Met Met
225 230 235 240
Arg Val Ala Cys Ile Lys Asp His Asn Leu Ser Thr Ile Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Ala Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Asn Met Pro Val Gly Glu Gly Tyr Glu Leu Ile Arg
290 295 300
Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ser Thr Ala Pro Leu Pro
305 310 315 320
Lys Asn Thr Asp Pro Glu Ile Ile Asp His Val Leu Lys Asn Tyr Lys
325 330 335
Ser Lys Asn Met Met Thr Phe Leu Ser Tyr Asp Leu Arg
340 345
<210> 119
<211> 350
<212> PRT
<213> 非洲猪瘟病毒
<400> 119
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Tyr Tyr Asp Leu Trp
20 25 30
Trp His Asp Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Lys Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Ser Ser Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Lys
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile Tyr Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Met Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Thr Thr Ile Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Phe Ser Lys Asn Met Met Ile Phe Leu Ser Tyr Asp Leu Arg
340 345 350
<210> 120
<211> 350
<212> PRT
<213> 非洲猪瘟病毒
<400> 120
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Gly Pro Ile Thr Phe Asp His Asn Leu Lys Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asn Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Ala Phe Glu Glu Gly Thr Ile Ala Leu Gly Glu Gly Tyr Lys Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 121
<211> 350
<212> PRT
<213> 非洲猪瘟病毒
<400> 121
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asn Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Ser Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Met Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 122
<211> 350
<212> PRT
<213> 非洲猪瘟病毒
<400> 122
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Gly Pro Ile Thr Phe Asp His Asn Leu Lys Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Arg Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile Tyr Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Val Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Ala Phe Glu Glu Gly Thr Ile Ala Leu Gly Glu Gly Tyr Lys Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Val Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 123
<211> 350
<212> PRT
<213> 非洲猪瘟病毒
<400> 123
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Gly Pro Ile Thr Phe Asp His Asn Leu Lys Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asn Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Arg Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Ala Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Ala Phe Glu Glu Gly Thr Ile Ala Leu Gly Glu Gly Tyr Lys Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 124
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 124
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Cys Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Arg Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Arg Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Met Leu Glu Asn Lys Phe Val Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Val Cys
180 185 190
Lys Asn Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Lys Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Cys Ala Lys Asp Asn Asn Leu Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Val Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Thr Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Lys Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 125
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 125
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Ile Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Cys Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Arg Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Gly Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Arg Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Ile Leu Glu Asn Lys Phe Val Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Gly Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Asp Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Glu Asn Ile Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Ala Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 126
<211> 352
<212> PRT
<213> 非洲猪瘟病毒
<400> 126
Met Ser Ser Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Gly Thr Ser Cys Leu Ser Ile Asp Glu His Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Tyr Ile Asp Arg Gly Arg
35 40 45
Ile Tyr Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Cys Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Met Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Tyr Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ala Arg Asp Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Asp Asp Tyr Asp Ile Phe Cys Ile Phe Asn Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Ile Asn Asn
130 135 140
Pro Asn Leu Glu Asn Asn Phe Ala Ala Gln Leu Arg Arg Leu Ile Tyr
145 150 155 160
Lys Arg Leu Cys Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Ser
165 170 175
Glu Leu Leu Val Lys Tyr Trp Tyr Ala Asn Ala Val Gln Tyr Asp His
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asp Glu
195 200 205
Trp Leu Lys Cys Tyr Leu Cys Tyr Asn Lys Ile Tyr Glu Leu His Asp
210 215 220
Ile Tyr His Lys Glu Lys Ile Gln Ile Asp Val Asn Glu Met Leu Ser
225 230 235 240
Leu Ala Cys Ile Arg Asp Asn Asn Leu Leu Thr Ile Tyr Tyr Cys Tyr
245 250 255
Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln Tyr
260 265 270
Tyr Asn Ile Gly Asn Ile Tyr Phe Cys Ile Asp Leu Gly Gly Asn Ala
275 280 285
Phe Glu Glu Gly Ser Ala Ile Ala Arg Gln Asn Gly Tyr Asn Phe Leu
290 295 300
Ser His Ser Leu Val Leu Asn Ile Tyr Ser Ser Asp Ala Ser Leu Pro
305 310 315 320
Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asn Tyr
325 330 335
Lys Ser Lys Asn Leu Ser Ile Ile Leu Asp Tyr Ser His Lys Ile Leu
340 345 350
<210> 127
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 127
Met Ser Ser Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Thr Ser Cys Leu Ser Ile Asp Glu His Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Tyr Ile Asp Arg Gly Arg
35 40 45
Ile Tyr Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Cys Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Tyr Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ala Arg Asp Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Asp Asp Tyr Asp Ile Phe Cys Ile Phe Asn Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Ile Asn Asn
130 135 140
Pro Lys Leu Glu Asn Asn Phe Ala Ala Gln Leu Arg Arg Leu Ile Tyr
145 150 155 160
Lys Arg Leu Cys Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Ser
165 170 175
Glu Leu Leu Val Lys Tyr Trp Tyr Ala Asn Ala Val Gln Tyr Asp His
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asp Glu
195 200 205
Trp Arg Leu Lys Cys Tyr Leu Cys Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Asp Ile Tyr His Lys Lys Lys Ile Gln Ile Asp Val Asn Glu Met Leu
225 230 235 240
Ser Leu Ala Cys Ile Arg Asp Asn Asn Leu Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Tyr Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Ser Ala Ile Ala Arg Gln Asn Gly Tyr Asn Phe
290 295 300
Leu Cys His Ser Leu Ile Leu Asn Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Val Pro Glu Glu Ile Ser Ser Leu Leu Lys Asn
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Leu Asp Tyr Ser His Lys Ile
340 345 350
Leu
<210> 128
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 128
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Cys Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Arg Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Arg Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Met Leu Glu Asn Lys Phe Val Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Val Cys
180 185 190
Lys Asn Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Lys Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Cys Ala Lys Asp Asn Asn Leu Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Val Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Thr Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Lys Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 129
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 129
Met Ser Ala Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Thr Ser Cys Leu Ser Ile Asp Glu His Ile Leu Lys Tyr Cys Asp
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Tyr Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Cys Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Asn Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Leu Gly Ala Asn Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Val Arg Asp Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Tyr Asp Ile Phe Cys Ile Phe Asn Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Val Ile Leu Cys His Glu Ile Phe Ile Asn Asn
130 135 140
Pro Asn Leu Glu Asn Lys Phe Ala Ala Gln Leu Arg Arg Leu Ile Tyr
145 150 155 160
Lys Arg Leu Cys Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Ser
165 170 175
Glu Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Asp Tyr
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Tyr Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Asp Ile Tyr His Lys Glu Lys Ile Gln Ile Asp Val Asn Glu Met Leu
225 230 235 240
Ser Leu Ala Cys Ile Arg Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Tyr Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Ser Ala Ile Ala Arg Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Val Leu Asn Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asn
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Leu Asp Tyr Ser His Asn Ile
340 345 350
Leu
<210> 130
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 130
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Cys Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Arg Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Arg Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Ile Leu Glu Asn Lys Phe Val Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Lys Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Val Cys
180 185 190
Lys Asn Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Lys Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Cys Ala Lys Asp Asn Asn Leu Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Ser Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Thr Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 131
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 131
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys His Cys Gly
20 25 30
Leu Trp Trp His Asp Val Pro Leu Lys Leu Cys Met Asp Arg Gly Gln
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu His Ile
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala His Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Glu His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asp Asp Val Phe Arg Ile Phe Thr Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Arg Ile Ile Leu Cys His Asp Ile Phe Met Asn Asn
130 135 140
Pro Asn Ile Glu Asn Lys Phe Thr Ile Gln Leu Arg Gly Leu Ile Cys
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Glu Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Glu Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Phe Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Glu Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Ala Leu Asp Ile Phe Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Phe Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 132
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 132
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Asn Gln Ser Leu Ser Ile Asp Glu His Cys Ile Leu Lys His Cys Gly
20 25 30
Leu Trp Trp His Asp Val Pro Leu Lys Leu Cys Met Asp Arg Gly Gln
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu His Ile
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asp Asp Ile Phe Arg Ile Phe Thr Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Asp Ile Phe Met Asn Asn
130 135 140
Pro Asn Ile Glu Asp Lys Phe Thr Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Gly Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Glu Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Glu Asn Ile Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Ala Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 133
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 133
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Thr Asp Glu His Cys Ile Leu Lys His Cys Gly
20 25 30
Leu Trp Trp His Asp Val Pro Leu Lys Leu Cys Met Asp Arg Gly Gln
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu His Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala His Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Glu His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Lys Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Arg Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Asn Ile Glu Asn Lys Phe Thr Ile Gln Leu Arg Gly Leu Ile Cys
145 150 155 160
Lys Arg Leu Trp Arg Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Glu Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Gly Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Asp Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr His Phe
290 295 300
Leu Ser His Ser Leu Ala Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Gly
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 134
<211> 353
<212> PRT
<213> 非洲猪瘟病毒
<400> 134
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Thr Asp Glu His Cys Ile Leu Lys His Cys Gly
20 25 30
Leu Trp Trp His Asp Val Pro Leu Lys Leu Cys Met Asp Arg Gly Gln
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu His Ile
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala His Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Glu His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Arg Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Asn Ile Glu Asn Lys Phe Thr Ile Gln Leu Arg Gly Leu Ile Cys
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Glu Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Glu Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr His Phe
290 295 300
Leu Ser His Ser Leu Thr Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 135
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 135
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Val Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Tyr Leu Lys Arg Leu Cys Ala Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asn Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn Gln Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys His Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Ala Asp Phe Asp
275 280 285
Arg Ala Gln Leu Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Val Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Met Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 136
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 136
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Val Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Tyr Leu Lys Arg Leu Cys Ala Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Arg Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His His Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys His Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Ala Asp Phe Asp
275 280 285
Arg Ala Gln Leu Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Val Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 137
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 137
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Thr Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Gln His Leu Gln Cys Phe Ser Val Asp Asp Leu Cys Leu Asp Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val His Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Ser Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asp Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Met Glu Thr Val Thr Arg Thr Thr Leu Asn Thr Val Met Tyr
145 150 155 160
Thr Arg Ser Lys Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Glu Lys His Lys Asn Gln Leu Tyr Trp Arg Leu
195 200 205
Thr Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Leu His Glu Leu Cys
210 215 220
Ser Lys Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Glu Asn Tyr Ala Ala Ile Tyr Tyr Cys His Met Leu
245 250 255
Gly Ala Ser Pro Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Leu Phe Phe Cys Ile Asp Leu Gly Ala Thr Asn Phe Asp
275 280 285
Arg Ala Arg Leu Ile Ala His Arg Val Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Ala Ser Leu Val Leu
305 310 315 320
Asn Ile Thr Glu Pro Gln Ala Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Phe Thr Ala His Pro Glu
340 345 350
Ile Val Val Ile Asp
355
<210> 138
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 138
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Thr Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Gln His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Asp Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Asp Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Ser Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asp Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asn Thr Val Met Tyr
145 150 155 160
Thr Arg Ser Lys Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Glu Lys His Lys Asn Gln Leu Tyr Trp Arg Leu
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Leu His Glu Leu Cys
210 215 220
Ser Lys Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Glu Asn Tyr Ala Ala Ile Tyr Tyr Cys His Met Leu
245 250 255
Gly Ala Ser Pro Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Leu Phe Phe Cys Ile Asp Leu Gly Ala Thr Asn Phe Asp
275 280 285
Arg Ala Arg Leu Ile Ala His Arg Val Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Ala Ser Leu Val Leu
305 310 315 320
Asn Ile Thr Glu Pro Gln Ala Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Phe Thr Ala His Pro Glu
340 345 350
Ile Val Val Ile Asp
355
<210> 139
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 139
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Val Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Tyr Leu Lys Arg Leu Cys Ala Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asn Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn Gln Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys His Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Ala Asp Phe Asp
275 280 285
Arg Ala Gln Leu Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Val Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Met Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 140
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 140
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Thr Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val His Leu Lys Arg Leu Cys Met Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Ser Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asp Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Met Tyr
145 150 155 160
Thr Arg Ser Lys Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Ser Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Glu Lys His Lys Asn Gln Leu Tyr Trp Arg Leu
195 200 205
Thr Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Leu His Glu Leu Cys
210 215 220
Cys Lys Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Glu Asn Tyr Ala Ala Ile Tyr Tyr Cys His Met Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Leu Phe Phe Cys Ile Asp Leu Gly Ala Thr Asn Phe Asp
275 280 285
Arg Ala Arg Leu Ile Ala Arg Arg Val Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Leu Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Ser Leu Ile Leu
305 310 315 320
Asp Leu Thr Glu Pro Gln Ala Ile Tyr Asp Met Leu Asn Thr Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Gln Ala Glu Glu Tyr Phe Thr Ala His Pro Glu
340 345 350
Ile Val Val Ile Asp
355
<210> 141
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 141
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Val Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Tyr Leu Lys Arg Leu Cys Ala Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asn Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn Gln Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys His Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Ala Asp Phe Asp
275 280 285
Arg Ala Gln Leu Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Val Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Met Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 142
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 142
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val His Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Thr Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Lys Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Gln Lys Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys Tyr Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Thr Asp Phe Asp
275 280 285
Arg Ala Gln His Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Ala Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Arg Leu Lys Ser Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 143
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 143
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Lys His Val Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val His Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Ser Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Arg Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His His Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Gln Lys Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys Tyr Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Thr Asp Phe Asp
275 280 285
Arg Ala Gln Arg Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Ala Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Ser Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 144
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 144
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Met Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Arg Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Cys Val Pro
85 90 95
Thr Val His Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asn Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys Tyr Asn
130 135 140
Pro Leu Leu Glu Thr Ile Thr Arg Thr Thr Leu Asp Thr Val Met Tyr
145 150 155 160
Ser Cys Ser Lys Ile Pro Leu Met Gly Asp Thr Ala His His Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys Tyr Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Ser Leu Asn Leu Phe Phe Cys Ile Asp Leu Gly Ala Thr Asp Phe Asp
275 280 285
Arg Ala Gln Arg Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Leu Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Ala Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Arg Leu Lys Ala Tyr Thr
325 330 335
Ser Lys Asn Met Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 145
<211> 357
<212> PRT
<213> 非洲猪瘟病毒
<400> 145
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Met Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val His Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Lys Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His His Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Lys Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys Tyr Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Thr Asp Phe Asp
275 280 285
Arg Ala Gln Arg Ile Ala His Lys Thr Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Ala Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Ser Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 146
<211> 531
<212> PRT
<213> 非洲猪瘟病毒
<400> 146
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Gly Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg Tyr
85 90 95
Asn Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Asp Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Ile Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys Tyr Thr Leu Glu Asp Asp Leu
145 150 155 160
Pro Leu Val His Leu Leu Ile Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Val Cys His Ile Ile
180 185 190
Asp Thr Phe Asp Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
His Leu Asp Ile Leu Ile Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Ile Asp Asn Leu Asp Val Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Val Ala Ile Lys Thr Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Ile Gln Lys Ile Ser Gln Tyr Val Ala Thr Phe Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Lys Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Asn Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Glu Arg Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Asn Lys Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Ala Arg Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Glu His Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asn Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 147
<211> 531
<212> PRT
<213> 非洲猪瘟病毒
<400> 147
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asn Arg Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Thr Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Gln Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys His Arg Leu Glu Asp Asp Leu
145 150 155 160
Pro Phe Thr His Leu Leu Ile Glu Lys Ala Cys Lys Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asn Met Ile
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu His Leu Tyr Cys
195 200 205
Leu Gly Tyr Arg Phe Ile Tyr Asn Arg Ile Val Pro Asp Lys Tyr His
210 215 220
His Leu Asp Ile Arg Met Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Lys Asp Asn Ile Asn Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Ile Tyr Phe Ile Pro Gln Ser Thr His Ala
275 280 285
Gln Ile Glu Gln Cys Leu Leu Val Ala Ile Lys Ala Lys Ser Ser Arg
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Asn Leu
305 310 315 320
Ile Lys Lys Ile Ser His Tyr Val Ala Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Arg Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Lys Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Leu Lys Ile
370 375 380
Ala Ala Arg Ile Asn Arg Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Val Arg Leu Lys Tyr Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp Arg Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Val Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys Gln
515 520 525
Tyr Met Pro
530
<210> 148
<211> 530
<212> PRT
<213> 非洲猪瘟病毒
<400> 148
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Val Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Asn Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asn Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asn Cys Met Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Ser Val Leu Leu Tyr Phe Lys Tyr Ile Leu Lys Glu Asn Leu
145 150 155 160
Pro Leu Val His Ser Leu Ile Glu Lys Ala Tyr Lys Tyr His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asp Ile Ile
180 185 190
Asn Thr Phe Lys Tyr Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Val Tyr Asn Arg Ile Val Pro Tyr Lys Tyr Tyr
210 215 220
His Leu Asp Ile Arg Ile Leu Leu Arg Leu Gln Leu Leu His Lys Val
225 230 235 240
Thr Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Thr Asn Asn Ile Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Asn Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Val Ala Ile Lys Thr Asn Ala Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Val Lys Lys Leu Ser Gln Tyr Val Val Ala Tyr Lys Ser Thr Asn Ile
325 330 335
Ile Ser Ile Leu Ser Met Gln Gln Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Val Val Lys Asn Ala Val Phe Ile Lys Phe Val Ile
355 360 365
Gly Cys Met Val Thr Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Lys Lys Met Lys Leu Val Lys Asn Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Ala Lys Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Gln Glu Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp His Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Ala Lys Asn Ala His Asp Ala Ser Ile Asn
485 490 495
Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu Ser
500 505 510
Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys Tyr Asp
515 520 525
Ile Leu
530
<210> 149
<211> 530
<212> PRT
<213> 非洲猪瘟病毒
<400> 149
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Val Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Asn Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn His His
85 90 95
Asn Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Thr Met
115 120 125
Arg Arg Cys Phe Phe Asn Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Ser Val Leu Leu Tyr Phe Lys Tyr Ile Leu Lys Glu Asn Leu
145 150 155 160
Pro Leu Val His Ser Leu Ile Glu Lys Ala Tyr Lys Tyr His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asp Ile Ile
180 185 190
Asn Thr Phe Lys Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Val Tyr Asn Arg Ile Val Pro Tyr Lys Tyr Tyr
210 215 220
His Leu Asp Ile Arg Ile Leu Leu Arg Leu Gln Leu Leu His Lys Val
225 230 235 240
Thr Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Thr Asn Asn Ile Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Asn Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Val Ala Ile Lys Thr Asn Ala Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Val Lys Lys Leu Ser Gln Tyr Val Val Ala Tyr Lys Ser Thr Asn Ile
325 330 335
Ile Ser Ile Leu Ser Arg Gln Gln Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Val Val Lys Asn Ala Val Phe Asn Lys Phe Val Ile
355 360 365
Gly Cys Met Val Thr Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Lys Lys Met Lys Leu Val Lys Asn Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Val Lys Leu Lys Tyr Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Gln Glu Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp His Cys Tyr Tyr His Met Gln Glu Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Val Lys Asn Ala His Asp Ala Ser Ile Asn
485 490 495
Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu Ser
500 505 510
Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys Asp Tyr
515 520 525
Met Leu
530
<210> 150
<211> 530
<212> PRT
<213> 非洲猪瘟病毒
<400> 150
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Arg Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Val Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Asn Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asn Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Met Met
115 120 125
Arg Arg Cys Phe Phe Asn Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Ser Val Leu Leu Tyr Phe Lys Tyr Ile Leu Lys Glu Asn Leu
145 150 155 160
Pro Leu Val His Ser Leu Ile Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Glu Ile Met
180 185 190
Asp Thr Phe Lys Cys Ala Ile Ala His Lys Asp Leu His Leu Tyr Ser
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
His Leu Asp Ile Arg Ile Leu Ser Arg Leu Gln Leu Leu His Lys Val
225 230 235 240
Thr Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Lys Asp Asn Ile Asn Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Asn Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Val Ala Ile Lys Thr Asn Ala Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Val Lys Lys Leu Ser Gln Tyr Val Val Ala Tyr Lys Ser Thr Asn Ile
325 330 335
Ile Ser Ile Leu Ser Met Gln Gln Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Val Val Lys Asn Ala Ile Phe Ile Lys Phe Val Ile
355 360 365
Gly Cys Met Val Thr Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Lys Lys Met Lys Leu Val Lys Asn Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Ala Lys Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Gln Glu Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp His Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser Tyr Ile Ile Ala Lys Asn Ala His Asp Ala Ser Ile Asn
485 490 495
Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu Ser
500 505 510
Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys Asp Tyr
515 520 525
Met Leu
530
<210> 151
<211> 531
<212> PRT
<213> 非洲猪瘟病毒
<400> 151
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Gly Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg Tyr
85 90 95
Asn Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Asp Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Ile Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys Tyr Thr Leu Glu Asp Asp Leu
145 150 155 160
Pro Leu Val His Leu Leu Ile Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Val Cys His Ile Ile
180 185 190
Asp Thr Phe Asp Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
His Leu Asp Ile Leu Ile Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Ile Asp Asn Leu Asp Val Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Val Ala Ile Lys Thr Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Ile Gln Lys Ile Ser Gln Tyr Val Ala Thr Phe Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Lys Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Asn Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Glu Arg Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Asn Lys Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Ala Arg Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Glu His Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asn Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 152
<211> 530
<212> PRT
<213> 非洲猪瘟病毒
<400> 152
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Asn Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg Pro
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Ile Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asn Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys His Arg Leu Gly Asp Asp Leu
145 150 155 160
Pro Leu Thr His Leu Leu Ile Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ser Tyr Asn Ile Met
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
His Leu Asp Ile Cys Ile Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Ile Asn Asn Ile Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Phe Ile Pro Gln Leu Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Leu Val Ala Ile Lys Thr Lys Ala Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Ile Lys Lys Ile Ser Gln Tyr Val Val Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Ser Ile Leu Ser Met Arg Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Glu Phe Val Lys Asn Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Asn Arg Met Met Leu Val Lys Asn Ile Ser Glu Arg
385 390 395 400
Val Trp Lys Asn His Ala Val Lys Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Gln Glu Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp His Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Gly Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Met Leu Asp Ala Thr Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Pro His Ile Ile Gly Lys Asn Ala Tyr Asp Ala Gly Ile Asn
485 490 495
Leu Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu Ser
500 505 510
Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His Asp
515 520 525
Met Phe
530
<210> 153
<211> 531
<212> PRT
<213> 非洲猪瘟病毒
<400> 153
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Ile Asn Glu Ala Leu Arg Thr Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys Tyr Arg Leu Glu Asp Asp Leu
145 150 155 160
Pro Leu Thr His Leu Leu Ile Glu Lys Ala Cys Glu Asn His Asn Tyr
165 170 175
Glu Val Ile Arg Trp Ile Tyr Glu Asn Leu His Ile Tyr Asn Met Ile
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Asn Lys Tyr His
210 215 220
His Ile Asp Ile Leu Ile Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Asn Asp Asn Leu Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Met Val Ala Ile Lys Thr Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Ile Lys Lys Ile Ser Gln Tyr Val Val Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Lys Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Leu Leu Thr Lys Phe Val Lys Asn Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Tyr Met Asp Thr Phe Ser Ile Asn Pro Glu Lys Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Asn Lys Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Ile Trp Lys Asn His Ala Ala Arg Leu Glu His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Glu Tyr Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asn Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Asp Asn Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 154
<211> 531
<212> PRT
<213> 非洲猪瘟病毒
<400> 154
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Val Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asn Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys Tyr Arg Leu Glu Asn Asp Leu
145 150 155 160
Pro Leu Ala His Leu Leu Val Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Leu Tyr Glu Asn Leu His Ile Tyr Asn Ile Met
180 185 190
Glu Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Arg
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
Tyr Leu Asp Val Leu Ile Leu Ser Gly Leu His Leu Leu Tyr Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Asn Asp Asn Leu Asp Ile Ile Leu Thr Gln Ala Val Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Tyr Ile Pro Gln Leu Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Met Ala Ile Lys Lys Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Lys Leu Ser Ile Lys Leu
305 310 315 320
Ile Lys Lys Ile Ser Gln Tyr Val Ala Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Asn Met Lys Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Tyr Ala Ile Phe Asn Lys Tyr Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Ile Lys Met
370 375 380
Ala Ala Arg Ile Asn Lys Met Leu Leu Val Lys Lys Ile Ser Gln His
385 390 395 400
Ala Trp Lys Asn His Ala Ala Arg Leu Lys His Leu Lys His Ala Val
405 410 415
Tyr Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Leu Ile
420 425 430
Tyr Asp His Tyr Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Leu Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Thr Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 155
<211> 531
<212> PRT
<213> 非洲猪瘟病毒
<400> 155
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Asn Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Gln Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Ser Phe Lys His Arg Leu Arg Asp Asp Leu
145 150 155 160
Pro Phe Thr His Leu Leu Ile Glu Lys Ala Cys Lys Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asn Met Ile
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Arg Phe Ile Tyr Asn Arg Ile Val Pro Asp Lys Tyr His
210 215 220
His Leu Asp Ile Arg Met Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Lys Asp Asn Ile Asn Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Ile Tyr Phe Ile Pro Gln Ser Thr His Ala
275 280 285
Gln Ile Glu Gln Cys Leu Leu Val Ala Ile Lys Thr Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Asn Leu
305 310 315 320
Ile Lys Lys Ile Ser His Tyr Val Ala Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Arg Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Lys Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Leu Lys Ile
370 375 380
Ala Ala Arg Ile Asn Arg Thr Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Val Arg Leu Lys Tyr Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp Arg Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Val Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 156
<211> 531
<212> PRT
<213> 非洲猪瘟病毒
<400> 156
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln Arg Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Gly Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Ile
115 120 125
Arg Arg Cys Phe Phe Asn Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys His Arg Leu Glu Asp Asp Leu
145 150 155 160
Pro Leu Thr His Leu Leu Ile Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Thr Tyr Asp Ile Met
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Glu Tyr His
210 215 220
His Leu Asp Ile Leu Ile Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Asn Asp Asn Leu Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Phe Ile Pro Gln Leu Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Met Ala Ile Lys Arg Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Thr Leu Ser Ile Glu Leu
305 310 315 320
Ile Lys Lys Ile Ser Gln Tyr Val Val Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Lys Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Met Leu Thr Lys Tyr Val Lys Tyr Ala Ile Phe Asn Lys Tyr Val Val
355 360 365
Arg Cys Met Asp Arg Phe Ser Ile Asn Pro Glu Arg Ile Ile Lys Met
370 375 380
Ala Ala Arg Ile Asn Arg Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Ala Arg Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp Arg Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Gln Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asp Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Leu
530
<210> 157
<211> 531
<212> PRT
<213> 非洲猪瘟病毒
<400> 157
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys Tyr Arg Leu Glu Asn Asp Leu
145 150 155 160
Pro Leu Ala His Leu Leu Ile Lys Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asn Ile Met
180 185 190
Asp Thr Phe Gly Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Arg
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
Tyr Leu Asp Val Leu Ile Leu Ser Gly Leu His Leu Leu Tyr Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Asn Asp Asn Leu Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Tyr Ile Pro Gln Leu Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Met Ala Ile Lys Lys Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Lys Leu Ser Ile Lys Leu
305 310 315 320
Ile Lys Lys Ile Ser Gln Tyr Val Ala Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Asn Met Arg Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Lys Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Ile Lys Met
370 375 380
Ala Ala Arg Ile Asn Lys Met Leu Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Ala Trp Lys Asn His Ala Ala Arg Leu Lys His Leu Lys His Ala Val
405 410 415
Tyr Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Leu Ile
420 425 430
Tyr Asp His Tyr Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Leu Leu Asp Thr Ile Arg Phe Lys Asn Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Thr Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 158
<211> 438
<212> DNA
<213> 非洲猪瘟病毒
<400> 158
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac tgctccctct 360
gaagaaaaga ctaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 159
<211> 438
<212> DNA
<213> 非洲猪瘟病毒
<400> 159
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg tcatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttaatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
aggctgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ctaaccatct tctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 160
<211> 438
<212> DNA
<213> 非洲猪瘟病毒
<400> 160
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg tcatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttaatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
aggctgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ctaaccatct tctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 161
<211> 438
<212> DNA
<213> 非洲猪瘟病毒
<400> 161
atggatcatt atcttaaaaa attacaggat atttataaga agcttgaggg tcaccccttt 60
ctttttagtc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaagccttg 120
gcctcgacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttgttaacta tattaaagcg agtaaacaag agtatttatg tctgttgatt 240
aatcctaaac tagtcactaa gtttttaaaa ataacgagct ttaaaattta cattaatttt 300
aggctgaaaa ctttttatat aagtcctaat aagtataata atttttacat cgctccctct 360
gaagaaaagg ccaatcatct cctaaaagaa gaaaaaacct gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 162
<211> 438
<212> DNA
<213> 非洲猪瘟病毒
<400> 162
atggatcatt atcttaaaaa attacaggat atttataaga agcttgaggg tcaccccttt 60
ctttttagtc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaagccttg 120
gcctcgacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttgttaacta tattaaagcg agtaaacaag agtatttatg tctgttgatt 240
aatcctaaac tagtcactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
aggctaaaaa ctttctatat aagtcctaat aagtataata atttttacat cgctccctct 360
gaagaaaagg ccaatcatct cctaaaagaa gaaaaaacct gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 163
<211> 438
<212> DNA
<213> 非洲猪瘟病毒
<400> 163
atggatcatt atcttaaaaa attacaggat atttataaga agcttgaggg tcaccccttt 60
ctttttagtc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaagccttg 120
gcctcgacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttgttaacta tattaaagcg agtaaacaag agtatttatg tctgttgatt 240
aatcctaaac tagtcactaa gtttttaaaa ataacgagct ttaaaattta cattaatttt 300
aggctgaaaa ctttttatat aagtcctaat aagtataata atttttacat cgctccctct 360
gaagaaaagg ccaatcatct cctaaaagaa gaaaaaacct gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 164
<211> 438
<212> DNA
<213> 非洲猪瘟病毒
<400> 164
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac tgctccctct 360
gaagaaaaga ctaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 165
<211> 438
<212> DNA
<213> 非洲猪瘟病毒
<400> 165
atggatcatt atcttaaaaa attagaggat atttataaaa agcttgaggg tcatcccttt 60
ctttttagtc cgtcgaaaac caatgaaaaa gagtttatta ctctgttaaa ccaagccttg 120
gcctcaacgc agctttatcg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatc 240
aatcctaaac tagttacgaa gtttttaaaa ataacgagtt ttaaaattta cattaatttc 300
aggctgaaaa ctttttatat aagtcctaat aaatataata atttttacac cgctccctct 360
gaagaaaagg ccaatcatct cctaaaagaa gaaaaaacct gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 166
<211> 441
<212> DNA
<213> 非洲猪瘟病毒
<400> 166
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cctatagggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ccaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggaggag aagaatccta a 441
<210> 167
<211> 438
<212> DNA
<213> 非洲猪瘟病毒
<400> 167
atggatcatt atcttaaaaa attacaagaa atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttatcg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgtcactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ccaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 168
<211> 438
<212> DNA
<213> 非洲猪瘟病毒
<400> 168
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg tcatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ctaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 169
<211> 441
<212> DNA
<213> 非洲猪瘟病毒
<400> 169
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cctatagggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ccaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggaggag aagaatccta a 441
<210> 170
<211> 438
<212> DNA
<213> 非洲猪瘟病毒
<400> 170
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgtcactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ccaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 171
<211> 145
<212> PRT
<213> 非洲猪瘟病毒
<400> 171
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 172
<211> 145
<212> PRT
<213> 非洲猪瘟病毒
<400> 172
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 173
<211> 145
<212> PRT
<213> 非洲猪瘟病毒
<400> 173
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Lys Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Val Asn Tyr Ile Lys Ala Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Ile Ala Pro Ser Glu Glu Lys Ala Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 174
<211> 145
<212> PRT
<213> 非洲猪瘟病毒
<400> 174
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Lys Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Val Asn Tyr Ile Lys Ala Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Ile Ala Pro Ser Glu Glu Lys Ala Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 175
<211> 145
<212> PRT
<213> 非洲猪瘟病毒
<400> 175
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Lys Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Val Asn Tyr Ile Lys Ala Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Ile Ala Pro Ser Glu Glu Lys Ala Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 176
<211> 145
<212> PRT
<213> 非洲猪瘟病毒
<400> 176
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 177
<211> 145
<212> PRT
<213> 非洲猪瘟病毒
<400> 177
Met Asp His Tyr Leu Lys Lys Leu Glu Asp Ile Tyr Lys Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Ala Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 178
<211> 146
<212> PRT
<213> 非洲猪瘟病毒
<400> 178
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Gly Glu
130 135 140
Glu Ser
145
<210> 179
<211> 145
<212> PRT
<213> 非洲猪瘟病毒
<400> 179
Met Asp His Tyr Leu Lys Lys Leu Gln Glu Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 180
<211> 145
<212> PRT
<213> 非洲猪瘟病毒
<400> 180
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 181
<211> 146
<212> PRT
<213> 非洲猪瘟病毒
<400> 181
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Gly Glu
130 135 140
Glu Ser
145
<210> 182
<211> 145
<212> PRT
<213> 非洲猪瘟病毒
<400> 182
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 183
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 183
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctagcagaaa aaaaaaactt tttggtgtat 120
gaattgcctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag cctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacttgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 184
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 184
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag cctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 185
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 185
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag cctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 186
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 186
atggcggttt atgcgaagga ccttgataat aacaaagagt taaaccaaaa attgatcaac 60
gatcagctta aaatcattga cacgcttttg ctagcagaaa aaaaaaactt tttggtgtac 120
gaactacctg cccattttga cttttcctcc ggcgaccctt tgggcagtca gcgcgacatt 180
tactatgcca tcataaaaag tctcgaggag cgcggattta ctgtcaaaat atgtatgaag 240
ggagaccgcg cccttctttt catcacctgg aaaaaaatac aatccattga gatcaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcgtt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 187
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 187
atggcggttt atgcgaagga ccttgataat aacaaagagt taaaccaaaa attgatcaac 60
gatcagctta aaattattga cacgcttttg ctggcagaaa aaaaaaactt tttggtgtac 120
gaactacctg cccattttga cttttcctcc ggcgaccctt tgggcagtca gcgcgacatt 180
tactatgcca tcataaaaag tctcgaggag cgcggattta ctgtcaaaat atgtatgaag 240
ggagaccgcg cccttctttt catcacctgg aaaaaaatac aatccattga gatcaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcgtt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 188
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 188
atggcggttt atgcgaagga ccttgataat aacaaagagt taaaccaaaa attgatcaac 60
gatcagctta aaatcattga cacgcttttg ctagcagaaa aaaaaaactt tttggtgtac 120
gaactacctg cccattttga cttttcctcc ggcgaccctt tgggcagtca gcgcgacatt 180
tactatgcca tcataaaaag tctcgaggag cgcggattta ctgtcaaaat atgtatgaag 240
ggagaccgcg cccttctttt catcacctgg aaaaaaatac aatccattga gatcaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcgtt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 189
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 189
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctagcagaaa aaaaaaactt tttggtgtat 120
gaattgcctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag cctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacttgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 190
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 190
atggcagttt atgcgaaaga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcaactta aaattattga cacgctgttg ctggcagaaa aaaaaaactt tttggtgcat 120
gaactacctg cccactatga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag tctcgaggag cgcggattta ctgtcaaaat ttgtatgaaa 240
ggagatcgcg cccttctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagatgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 191
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 191
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctagcagaaa aaaaaaactt tttggtgtat 120
gaattgcctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag cctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacttgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 192
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 192
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag tctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgcg ccctcctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 193
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 193
atggcggtgt atgcgaagga ccttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgtgacata 180
tactatgcca tcataaaaag tcttgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacctgg aaaaaaatac aatccattga aataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaatcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 194
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 194
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag tctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgcg ccctcctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 195
<211> 378
<212> DNA
<213> 非洲猪瘟病毒
<400> 195
atggcggttt atgcgaagga ccttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag tctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgcg ccctcctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 196
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 196
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 197
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 197
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 198
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 198
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala His Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Gly Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 199
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 199
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala His Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Gly Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 200
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 200
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala His Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Gly Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 201
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 201
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 202
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 202
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val His Glu Leu Pro Ala His Tyr Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 203
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 203
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 204
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 204
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 205
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 205
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ser Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 206
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 206
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 207
<211> 125
<212> PRT
<213> 非洲猪瘟病毒
<400> 207
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
Claims (23)
1.减毒非洲猪瘟(ASF)病毒，其中以下基因的表达和/或活性被破坏：
多基因家族(MGF)360 12L、13L和14L，以及
MGF 505 1R，
并且所述减毒ASF病毒包含以下基因的功能形式：
(i)MGF 360 10L和/或11L，以及
(ii)MGF 505 2R和/或3R。
2.根据权利要求1的减毒ASF病毒，其包含MGF 360 10L和11L的功能形式。
3.根据权利要求1或2的减毒ASF病毒，其包含MGF 505 2R和3R的功能形式。
4.根据权利要求1至3中任一项的减毒ASF病毒，其中以下基因的一个或多个至少部分缺失：
MGF 360 12L、13L和14L，以及
MGF 505 1R。
5.根据权利要求1至4中任一项的减毒ASF病毒，其中以下基因的一个或多个完全缺失：
MGF 360 12L、13L和14L，以及
MGF 505 1R。
6.根据权利要求1至5中任一项的减毒病毒，其中以下基因的一个或多个被中断：
MGF 360 12L、13L和14L，以及
MGF 505 1R。
7.根据权利要求1至6中任一项的减毒ASF病毒，其包含区分感染和免疫动物(DIVA)突变。
8.根据权利要求7的减毒ASF病毒，其中所述DIVA突变缺乏K145R基因的功能形式和/或缺乏B125R基因的功能形式。
9.减毒ASF病毒，其缺乏K145R基因和/或B125R基因的功能形式。
10.根据权利要求8或9的减毒ASF病毒，其中所述K145R基因和/或所述B125R基因至少部分缺失。
11.根据权利要求8至10中任一项的减毒ASF病毒，其中所述K145R基因和/或所述B125R基因完全缺失。
12.根据权利要求8至11中任一项的减毒ASF病毒，其中所述K145R基因和/或所述B125R基因被中断。
13.疫苗，其包含根据权利要求1至12中任一项的减毒ASF病毒。
14.根据权利要求13的疫苗，其用于治疗和/或预防受试者的非洲猪瘟。
15.治疗和/或预防受试者的非洲猪瘟的方法，其包括向所述受试者施用有效量的根据权利要求13的疫苗的步骤。
16.根据权利要求14使用的疫苗、或根据权利要求15的方法，其中所述受试者是家猪。
17.根据权利要求14或16使用的疫苗、或根据权利要求15或16的方法，其中所述疫苗遵循初免-加强方案施用。
18.使ASF病毒减毒的方法，其包括破坏以下基因的表达和/或活性：
MGF 360 12L、13L和14L，以及
MGF 505 1R，
同时保留以下基因的功能的步骤：
(i)MGF 360 10L和/或11L，以及
(ii)MGF 505 2R和/或3R。
19.根据权利要求18的方法，其中所述MGF 360 10L和11L基因的功能被保留。
20.根据权利要求18或19的方法，其中所述MGF 505 2R和3R基因的功能被保留。
21.根据权利要求18至20中任一项的方法，其中以下基因的一个或多个至少部分缺失：
MGF 360 12L、13L和14L，以及
MGF 505 1R。
22.根据权利要求18至21中任一项的方法，其中以下基因的一个或多个完全缺失：
MGF 360 12L、13L和14L，以及
MGF 505 1R。
23.根据权利要求18至22中任一项的方法，其中以下基因的一个或多个被中断：
MGF 360 12L、13L和14L，以及
MGF 505 1R。
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2003292.6A GB202003292D0 (en) | 2020-03-06 | 2020-03-06 | Vaccine |
| GBGB2003289.2A GB202003289D0 (en) | 2020-03-06 | 2020-03-06 | Vaccine |
| GB2003289.2 | 2020-03-06 | ||
| GB2003292.6 | 2020-03-06 | ||
| GB2005878.0 | 2020-04-22 | ||
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| CN110551695A (zh) * | 2019-08-14 | 2019-12-10 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 非洲猪瘟病毒四基因缺失弱毒株及其应用 |
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| US20230117978A1 (en) | 2023-04-20 |
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| CL2022002412A1 (es) | 2023-03-03 |
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