KR20230013017A - 아프리카 돼지 열병 바이러스 감염에 대한 백신 - Google Patents
아프리카 돼지 열병 바이러스 감염에 대한 백신 Download PDFInfo
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- KR20230013017A KR20230013017A KR1020227034853A KR20227034853A KR20230013017A KR 20230013017 A KR20230013017 A KR 20230013017A KR 1020227034853 A KR1020227034853 A KR 1020227034853A KR 20227034853 A KR20227034853 A KR 20227034853A KR 20230013017 A KR20230013017 A KR 20230013017A
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Abstract
본 발명은 약독화된 아프리카 돼지 열병 바이러스에 관한 것이다. 약독화된 바이러스는 병독성 바이러스에 의한 후속 챌린지로부터 돼지를 방어한다. 본 발명은 또한 아프리카 돼지 열병을 치료 및/또는 예방하기 위한 상기 약독화된 바이러스의 용도에 관한 것이다. 본 발명은 또한 특정 아미노산 치환을 포함하는 아프리카 돼지 열병 바이러스의 EP402R 단백질 뿐만 아니라, 상기 단백질을 코딩하는 폴리뉴클레오티드, 및 상기 단백질을 포함하는 아프리카 돼지 열병 바이러스에 관한 것이다.
Description
본 발명은 약독화된 아프리카 돼지 열병 바이러스에 관한 것이다. 약독화된 바이러스는 병독성 바이러스에 의한 후속 챌린지로부터 돼지를 방어한다. 본 발명은 또한 아프리카 돼지 열병을 치료 및/또는 예방하기 위한 상기 약독화된 바이러스의 용도에 관한 것이다. 본 발명은 또한 특정 아미노산 치환을 포함하는 아프리카 돼지 열병 바이러스의 EP402R 단백질 뿐만 아니라, 상기 단백질을 코딩하는 폴리뉴클레오티드, 및 상기 단백질을 포함하는 아프리카 돼지 열병 바이러스에 관한 것이다.
아프리카 돼지 열병 (
ASF
)
아프리카 돼지 열병은 이중-가닥 DNA 바이러스인 아프리카 돼지 열병 바이러스 (ASFV)에 의해 가축용 돼지에서 유발되는 치명적인 출혈성 질환이다. ASFV는 우세하게 세포의 세포질에서 복제하는 아스파비리다에(Asfarviridae) 과의 유일한 구성원이다. ASFV의 병독성 균주는 감염 후 약 5-14일 이내에 가축용 돼지를 죽일 수 있으며, 치사율은 100%에 달한다.
ASFV는 와트호그 (파코초에루스 종(Phacochoerus sp .)), 부시피그 (포타모초에루스 종(Potamochoerus sp .)) 및 오르니토도로스(Ornithodoros) 종의 연진드기 (벡터로 간주)에서 감염 및 복제할 수 있지만, 이러한 종에서는 임상 징후가 관찰되는 경우는 거의 없으며, 장기간 지속적인 감염이 확립될 수 있다. ASFV는 유럽 정착민이 돼지를 ASFV 고유 지역으로 가져온 후 처음 기재되었으며, 따라서, "신종 감염"의 한 예이다. 상기 질환은 현재 사하라 사막 이남의 많은 국가와 사르데냐의 유럽에서 풍토병이다. ASFV는 2007년 트랜스 코카서스 지역의 조지아에 도입된 후 러시아 연방을 비롯한 주변 국가로 광범위하게 퍼졌다. 2012년, 우크라이나에서 첫 발병이 보고되었으며, 2013년에는 벨로루시에서 첫 발병이 보고되었다. 2014년에는 우크라이나의 돼지에서 추가 발병이 보고되었으며, 리투아니아와 폴란드의 멧돼지에서 검출되었다. 2018년, ASFV는 중국으로 확산되었고, 이후 중국과 다른 여러 아시아 국가 (몽골, 베트남, 캄보디아, 미얀마, 한국 및 북한, 인도네시아, 필리핀, 파푸아뉴기니, 동티모르)로 광범위하게 퍼졌다.
현재 ASF에 대한 치료법은 없다. 아프리카 이외의 국가에서는 수입 돼지 및 돼지고기 제품에 대한 반입 제한, 돼지에게 먹이기 전에 허가 하에 폐축산물을 강제로 끓이기, 질환 진단시 도축 정책을 적용하는 등 국가 차원에서 예방을 시도하고 있다. 아프리카에서 방지는 와트호그, 및 와트호그에 오염된 물질을 무리에서 멀리 떨어뜨리는 조치를 기반으로 한다.
따라서, ASFV 감염을 제어하고, 질환 확산을 예방하기 위한 개선된 조치가 요구된다.
아프리카 돼지 열병 바이러스 (
ASFV
)
ASFV 분리주 Benin 97/1 (서아프리카로부터의 고병원성 바이러스, 그룹 1), 분리주 OURT88/3 (포르투갈로부터의 비-병원성, 약독화된 바이러스, 그룹 1) 및 분리주 BA71V (Vero 세포 조직 배양 적합화된 비-병원성 바이러스, 그룹 1)의 완전 게놈 서열을 비교하였다 (Chapman et al. 2008 J. Gen. Virol. 89: 397-408). 유전자형 II 분리주 Georgia 2007/1의 완전한 게놈 또는 서열분석되었다 (Chapman et al. 2011 Emerg Infect Dis 17(4): 599-605).
OURT88/3 게놈에서 다중유전자 패밀리 (MGF) 360 18R (DP148R) 유전자, EP153R 유전자 및 EP402R 유전자는 각각 프레임 시프트 돌연변이에 의해 중단된다. 추가로, 하기 MGF 유전자는 OURT88/3 게놈에 부재한다: MGF 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L, MGF 300 3L, MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R, 및 MGF 505 1R, 2R 및 6R. MGF 505 3R 유전자 또한 말단절단되어 있다.
고병독성 Lisboa60 균주 및 저병독성 NH/P68 균주의 서열 또한 비교하였다 (Portugal et al. 2015 J. Gen. Virol. 96: 408-419).
NH/P68 게놈에서, MGF 360 18R (DP148R) 유전자, EP153R 유전자 및 EP402R 유전자는 각각 조기 정지 코돈에 의해 중단된다. 추가로, 하기 MGF 유전자는 NH/P68 게놈에 부재한다: MGF 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L, MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R, 및 MGF 505 1R, 2R 및 6R. MGF 360 9L 및 MGF 505 3R 유전자 또한 말단절단되어 있다.
고병독성 BA71 균주 및 저병독성 BA71V 균주의 서열도 비교하였다 (Rodriguez et al. 2015 PLoS ONE 10(11): e0142889).
병독성 Benin 97/1 분리주로부터의 DP148R 유전자의 결실은 병독성을 감소시키고, 모체 바이러스에 의한 챌린지로부터의 방어를 유도하였다 (Reis et al. 2017 J. Virol. 91, 24: e01428-17).
감염된 동물 및
백신접종받은
동물 감별(Differentiation of Infected and Vaccinated Animals:
DIVA) 백신
DIVA 백신 (마커 백신으로도 지칭)을 통해 야생형 병원체로 감염된 동물을 백신으로 면역화된 동물과 감별할 수 있다. DIVA 백신에는 야생형 병원체에 존재하는 적어도 하나의 면역원성 항원 (DIVA 마커)이 결여되어 있다. 야생형 병원체로 감염된 동물은 DIVA 마커에 대한 항체를 생산하는 반면, 백신접종받은 동물은 상기 항체를 생산하지 않는다. DIVA 마커에 대한 항체는 혈청학적 검정법을 사용하여 검출할 수 있다. 따라서, 두 동물 그룹 모두 병원체의 다른 면역원에 대한 항체가 있음에도 불구하고, (DIVA 마커에 대한 항체가 있는) 감염된 동물은 (DIVA 마커에 대한 항체가 없는) 백신접종받은 동물로부터 감별될 수 있다.
DIVA 마커는 면역원성이어야 하지만, 유전자의 결실이 백신의 방어 능력에 영향을 미치지 않아야 한다.
일반적으로, 본 발명은 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되는 반면, 특정 MGF 유전자의 발현 및/또는 활성은 파괴되지 않는 약독화된 아프리카 돼지 열병 바이러스에 관한 것이다.
본 발명은 또한 백신접종받은 동물로부터의 감염된 동물 감별 (DIVA) 돌연변이와 함께 조합하여 EP153R 및 EP402R 유전자의 발현 및/또는 활성의 파괴가 아프리카 돼지 열병 바이러스를 약독화시킬 수 있다는 결정에 관한 것이다. 본 발명은 특히 K145R 유전자의 DIVA 돌연변이에 관한 것이다.
본 발명은 또한 혈구흡착을 파괴하는, 아프리카 돼지 열병 바이러스의 EP402R 단백질 중의 특정 아미노산 변이의 결정에 관한 것이다. 따라서, 본 발명은 상기 아미노산 변이를 포함하는 EP402R 단백질, 상기 단백질을 코딩하는 폴리뉴클레오티드 및 상기 EP402R 단백질 및 폴리뉴클레오티드를 포함하는 아프리카 돼지 열병 바이러스를 포함한다.
추가로, 본 발명은 EP402R의 아미노산 변이는 아프리카 돼지 열병 바이러스를 약독화시키는 EP153R 유전자의 활성 및/또는 발현 파괴 및/또는 DIVA 돌연변이와 함께 조합될 수 있다는 점에서 상기한 것과의 조합에 관한 것이다.
본 발명의 약독화된 아프리카 돼지 열병 바이러스는 본원 실시예에서 입증된 바와 같이, 백신에서 사용될 때, 야생형 아프리카 돼지 열병 바이러스 균주에 의한 감염으로부터 방어를 제공하는 바 특히 유익하다.
한 측면에서, 본 발명은 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고; 하기 유전자:
다중유전자 패밀리 (MGF) 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L,
MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R, 및
MGF 505 1R, 2R 및 6R 중 하나 이상의 기능성 버전을 포함하는 것인, 약독화된 아프리카 돼지 열병 (ASF) 바이러스를 제공한다.
본 발명은 또한 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고; 하기 유전자:
다중유전자 패밀리 (MGF) 110 5L, 6L, 8L 및 12L,
MGF 360 6L, 10L, 11L, 12L, 13L, 14L 및 21R, 및
MGF 505 1R 및 2R 중 하나 이상의 기능성 버전을 포함하는 것인, 약독화된 ASF 바이러스를 제공한다.
본 발명은 또한 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고; 하기 유전자:
다중유전자 패밀리 (MGF) 110 11L 및 12L,
MGF 360 6L, 10L, 11L, 12L, 13L, 및 14L, 및
MGF 505 1R 및 2R 중 하나 이상의 기능성 버전을 포함하는 것인, 약독화된 ASF 바이러스를 제공한다.
또 다른 측면에서, 본 발명은 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고, DIVA 돌연변이를 포함하는 것인, 약독화된 ASF 바이러스를 제공한다. 일부 실시양태에서, DIVA 돌연변이가 K145R 유전자의 발현을 파괴시킨다.
또 다른 측면에서, 본 발명은 아미노산 변이가 EP402R 단백질의 리간드 결합을 파괴시키는 것인, 리간드 결합 도메인 중 하나 이상의 아미노산 변이를 포함하는 EP402R 단백질을 제공한다.
또 다른 측면에서, 본 발명은 Georgia 2007/1 EP402R 단백질 (서열식별번호(SEQ ID No.) 24)의 Q96 및/또는 W99에 상응하는 위치에 아미노산 변이를 포함하는 EP402R 단백질을 제공한다.
본 발명은 또한 본 발명의 EP402R 단백질을 코딩하는 폴리뉴클레오티드를 제공한다.
본 발명은 또한 본 발명의 폴리뉴클레오티드를 포함하는 벡터를 제공한다.
또 다른 측면에서, 본 발명은 본 발명의 EP402R 단백질을 포함하는 ASF 바이러스를 제공한다. 본 발명은 또한 본 발명의 폴리뉴클레오티드를 포함하는 ASF 바이러스를 제공한다.
본 발명은 또한 대상체에서 질환을 치료 및/또는 예방하는 데 사용하기 위한 본 발명의 ASF 바이러스, 및 대상체에서 질병을 치료 및/또는 예방하기 위한 의약의 제조를 위한 본 발명의 ASF 바이러스의 용도를 제공한다.
본 발명은 또한 본 발명의 ASF 바이러스를 포함하는 제약 조성물로서, 상기 제약 조성물은 대상체에서 질환을 치료 및/또는 예방하는 데 사용하기 위한 것인 제약 조성물을 제공한다.
본 발명은 또한 본 발명의 ASF 바이러스를 포함하는 백신으로서, 상기 백신은 대상체에서 아프리카 돼지 열병을 치료 및/또는 예방하는 데 사용하기 위한 것인 백신을 제공한다.
본 발명은 또한 대상체에게 유효량의 본 발명에 따른 제약 조성물, 또는 유효량의 본 발명에 따른 백신을 투여하는 단계를 포함하는, 대상체에서 아프리카 돼지 열병을 치료 및/또는 예방하는 방법을 제공한다.
또 다른 측면에서, 본 발명은 EP402R 단백질의 리간드 결합 도메인 중 하나 이상의 아미노산(들)을 변이시키는 단계를 포함하고, 여기서, 아미노산 변이는 EP402R 단백질의 리간드 결합을 파괴시키는 것인, 본 발명의 ASF 바이러스를 제조하는 방법을 제공한다.
또 다른 측면에서, 본 발명은 Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96 및/또는 W99에 상응하는 위치에서 EP402R 단백질 중 하나 이상의 아미노산(들)을 변이시키는 단계를 포함하는, 본 발명의 ASF 바이러스를 제조하는 방법을 제공한다.
또 다른 측면에서, 본 발명은 EP402R 단백질의 리간드 결합 도메인 중 하나 이상의 아미노산(들)을 변이시키는 단계를 포함하고, 여기서, 아미노산 변이는 EP402R 단백질의 리간드 결합을 파괴시키는 것인, 혈구흡착을 유도하는 ASF 바이러스의 능력을 감소시키는 방법을 제공한다.
또 다른 측면에서, 본 발명은 Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96 및/또는 W99에 상응하는 위치에서 EP402R 단백질 중 하나 이상의 아미노산(들)을 변이시키는 단계를 포함하는, 혈구흡착을 유도하는 ASF 바이러스의 능력을 감소시키는 방법을 제공한다.
또 다른 측면에서, 본 발명은 또한 EP153R 및 EP402R 유전자의 발현 및/또는 활성을 파괴시키는 단계를 포함하는, ASF 바이러스를 약독화시키는 방법을 제공한다.
도 1은 표면 발현을 검출하기 위해 야생형 CD2v 유전자를 함유하는 약독화된 ASFV로 면역화된 돼지로부터의 혈청으로 염색된 야생형 (a) 또는 돌연변이체 (b) CD2v를 발현하는 비-투과성 세포의 공초점 현미경 이미지를 보여주는 것이다.
도 2는 HAD (혈구흡착) 검정법으로부터의 예시적인 이미지를 보여주는 것이다. Vero 세포를 T7RNA 폴리머라제를 발현하는 변형된 백시니아 바이러스 앙카라(Ankara)로 감염시키고, C-말단 HA 에피토프 태그가 있는 야생형 또는 돌연변이체 CD2v 전장 단백질을 발현하는 플라스미드 (pcDNA3)로 형질감염시켰다. 돼지 적혈구를 첨가하고, 적혈구의 표면에의 부착에 대해 세포를 관찰하였다. 야생형 Benin CD2v를 발현하는 플라스미드로 형질감염된 3개의 세포 주위에서 적혈구의 HAD가 관찰된다 (a). Y102 잔기가 D로 돌연변이된 CD2v를 발현하는 한 세포 주위에서 부분적인 HAD가 관찰된다 (b). 잔기 E99가 R로 돌연변이된 CD2v를 발현하는 세포의 경우 HAD는 관찰되지 않는다 (c).
도 3은 다양한 유전자형의 상이한 ASFV 분리주로부터의 CD2v 리간드 결합 도메인의 아미노산 서열의 정렬을 도시한 것이다. E99 및 다른 분리주 중의 상응하는 잔기는 황색으로 강조 표시되어 있다.
도 4는 HAD 검정법으로부터의 예시적인 이미지를 보여주는 것이다. Vero 세포를 T7RNA 폴리머라제를 발현하는 변형된 백시니아 바이러스 앙카라로 감염시키고, C-말단 HA 에피토프 태그가 있는 Benin 또는 Georgia 균주로부터의 야생형 또는 돌연변이체 CD2v 전장 단백질을 발현하는 플라스미드 (pcDNA3)로 형질감염시켰다. 돼지 적혈구를 첨가하고, 적혈구의 표면에의 부착에 대해 세포를 관찰하였다. 야생형 Benin CD2v를 발현하는 플라스미드로 형질감염된 4개의 세포 주위에서 (a), 및 야생형 Georgia CD2v를 발현하는 플라스미드로 형질감염된 2개의 세포 주위에서 (b) 적혈구의 HAD가 관찰된다. 잔기 Q96이 R로 돌연변이된 Georgia CD2v를 발현하는 세포 (c), 또는 형질감염되지 않은 Vero 세포 (d)의 경우 HAD는 관찰되지 않는다.
도 5는 K145R (a) 또는 B125R (b)을 발현하는 플라스미드로 형질감염된 Vero 세포를 보여주는 것이다. 녹색 염색은 발현된 단백질을 표시하는 것이고, 청색 DAPI 염료는 DNA를 검출하는 것이다.
도 6은 Vero 세포에서 발현되고, ASFV로 면역화된 돼지로부터의 항혈청에 의해 검출된 K145R (a) 및 B125R (b)을 보여주는 것이다. 세포를 고정시키고, 투과시키고, 발현된 단백질을 검출하기 위해 항-항-HA(적색)로 염색하고, 약독화된 유전자형 I Benin97/1 유전자 결실 ASFV 균주로 면역화된 돼지로부터의 혈청 (녹색)으로 염색하였다. 면역화 이전 및 면역화 후 38일째 수집된 혈청으로 염색된 세포의 이미지를 보여주는 것이다. DNA는 청색으로 염색된다.
도 7은 HAD 검정법으로부터의 예시적인 이미지를 보여주는 것이다. 대조군으로서 야생형 Georgia 2007/1 ASFV (a), 또는 GeorgiaΔK145RΔEP153RCD2vQ96R ASFV (b)로 돼지 골수 세포를 감염시키고, 돼지 적혈구를 첨가하였다. 감염 후 1일째 야생형 Georgia 2007/1로 감염된 세포에서는 HAD가 관찰되지만 (a), 감염 후 1일째 GeorgiaΔK145RΔEP153RCD2vQ96R로 감염된 세포에서는 관찰되지 않는다 (b).
도 8은 GeorgiaΔK145RΔEP153RCD2vQ96R ASFV (그룹 K)로 돼지를 면역화, 부스팅 및 챌린지하는 데 사용된 실험 프로토콜을 도시한 것이다.
도 9는 면역화 및 챌린지 동안 대조군, 비-면역화된 그룹 M (a) 및 GeorgiaΔK145RΔEP153RCD2vQ96R로 면역화된 그룹 K (b) 중의 돼지의 직장 체온을 보여주는 것이다.
도 10은 면역화 및 챌린지 동안 대조군, 비-면역화된 그룹 M (a) 및 GeorgiaΔK145RΔEP153RCD2vQ96R로 면역화된 그룹 K (b) 중의 돼지의 임상 점수를 보여주는 것이다.
도 11은 (챌린지 전 GeorgiaΔK145RΔEP153RCD2vQ96R로 면역화된) 그룹 K 및 그룹 M (비-면역화된 대조군)으로부터의 돼지에서 부검시 점수화된 상이한 기관의 육안 병변을 보여주는 것이다.
도 12는 VP72/B646L 주요 캡시드 단백질을 기반으로, 상업적으로 이용가능한 경쟁 ELISA를 사용하여 측정된, 면역화 및 챌린지 동안 그룹 K 중의 돼지의 항체 반응 (적색 파선)을 보여주는 것이다.
도 13은 면역화 및 챌린지 동안 그룹 K에서의 세포 매개 면역 반응을 보여주는 것이다. 말초 혈액 단핵 세포를 면역화 이전, 부스트 및 챌린지에 수집하고, ASFV 유전자형 I Benin 97/1 (적색 막대) 또는 ASFV 유전자형 II Georgia 2007/1 (녹색 막대)로 자극하였다. IFN 감마 생산 세포의 개수를 Elispot 검정법에 의해 측정하였다
도 14는 시간 경과에 따른, Georgia 2007/1 분리주로의 자극 후의 상이한 돼지에 대한 IFN 감마 생산 세포의 개수를 보여주는 것이다.
도 15는 면역화 및 챌린지 후 상이한 시점 (일째) (x축)에 전혈 중에서 검출된 감염성 바이러스의 수준을 보여주는 것이다. 돼지 골수 세포 중 한계 희석에 의해 바이러스 역가를 측정하고, 형광에 의해 감염된 세포를 검출하고, y축 상에 TCID50/ml로 표시한다. 상이한 돼지에 대한 값은 도면 상에 표시된 바와 같이 상이한 색상으로 제시된다.
도 2는 HAD (혈구흡착) 검정법으로부터의 예시적인 이미지를 보여주는 것이다. Vero 세포를 T7RNA 폴리머라제를 발현하는 변형된 백시니아 바이러스 앙카라(Ankara)로 감염시키고, C-말단 HA 에피토프 태그가 있는 야생형 또는 돌연변이체 CD2v 전장 단백질을 발현하는 플라스미드 (pcDNA3)로 형질감염시켰다. 돼지 적혈구를 첨가하고, 적혈구의 표면에의 부착에 대해 세포를 관찰하였다. 야생형 Benin CD2v를 발현하는 플라스미드로 형질감염된 3개의 세포 주위에서 적혈구의 HAD가 관찰된다 (a). Y102 잔기가 D로 돌연변이된 CD2v를 발현하는 한 세포 주위에서 부분적인 HAD가 관찰된다 (b). 잔기 E99가 R로 돌연변이된 CD2v를 발현하는 세포의 경우 HAD는 관찰되지 않는다 (c).
도 3은 다양한 유전자형의 상이한 ASFV 분리주로부터의 CD2v 리간드 결합 도메인의 아미노산 서열의 정렬을 도시한 것이다. E99 및 다른 분리주 중의 상응하는 잔기는 황색으로 강조 표시되어 있다.
도 4는 HAD 검정법으로부터의 예시적인 이미지를 보여주는 것이다. Vero 세포를 T7RNA 폴리머라제를 발현하는 변형된 백시니아 바이러스 앙카라로 감염시키고, C-말단 HA 에피토프 태그가 있는 Benin 또는 Georgia 균주로부터의 야생형 또는 돌연변이체 CD2v 전장 단백질을 발현하는 플라스미드 (pcDNA3)로 형질감염시켰다. 돼지 적혈구를 첨가하고, 적혈구의 표면에의 부착에 대해 세포를 관찰하였다. 야생형 Benin CD2v를 발현하는 플라스미드로 형질감염된 4개의 세포 주위에서 (a), 및 야생형 Georgia CD2v를 발현하는 플라스미드로 형질감염된 2개의 세포 주위에서 (b) 적혈구의 HAD가 관찰된다. 잔기 Q96이 R로 돌연변이된 Georgia CD2v를 발현하는 세포 (c), 또는 형질감염되지 않은 Vero 세포 (d)의 경우 HAD는 관찰되지 않는다.
도 5는 K145R (a) 또는 B125R (b)을 발현하는 플라스미드로 형질감염된 Vero 세포를 보여주는 것이다. 녹색 염색은 발현된 단백질을 표시하는 것이고, 청색 DAPI 염료는 DNA를 검출하는 것이다.
도 6은 Vero 세포에서 발현되고, ASFV로 면역화된 돼지로부터의 항혈청에 의해 검출된 K145R (a) 및 B125R (b)을 보여주는 것이다. 세포를 고정시키고, 투과시키고, 발현된 단백질을 검출하기 위해 항-항-HA(적색)로 염색하고, 약독화된 유전자형 I Benin97/1 유전자 결실 ASFV 균주로 면역화된 돼지로부터의 혈청 (녹색)으로 염색하였다. 면역화 이전 및 면역화 후 38일째 수집된 혈청으로 염색된 세포의 이미지를 보여주는 것이다. DNA는 청색으로 염색된다.
도 7은 HAD 검정법으로부터의 예시적인 이미지를 보여주는 것이다. 대조군으로서 야생형 Georgia 2007/1 ASFV (a), 또는 GeorgiaΔK145RΔEP153RCD2vQ96R ASFV (b)로 돼지 골수 세포를 감염시키고, 돼지 적혈구를 첨가하였다. 감염 후 1일째 야생형 Georgia 2007/1로 감염된 세포에서는 HAD가 관찰되지만 (a), 감염 후 1일째 GeorgiaΔK145RΔEP153RCD2vQ96R로 감염된 세포에서는 관찰되지 않는다 (b).
도 8은 GeorgiaΔK145RΔEP153RCD2vQ96R ASFV (그룹 K)로 돼지를 면역화, 부스팅 및 챌린지하는 데 사용된 실험 프로토콜을 도시한 것이다.
도 9는 면역화 및 챌린지 동안 대조군, 비-면역화된 그룹 M (a) 및 GeorgiaΔK145RΔEP153RCD2vQ96R로 면역화된 그룹 K (b) 중의 돼지의 직장 체온을 보여주는 것이다.
도 10은 면역화 및 챌린지 동안 대조군, 비-면역화된 그룹 M (a) 및 GeorgiaΔK145RΔEP153RCD2vQ96R로 면역화된 그룹 K (b) 중의 돼지의 임상 점수를 보여주는 것이다.
도 11은 (챌린지 전 GeorgiaΔK145RΔEP153RCD2vQ96R로 면역화된) 그룹 K 및 그룹 M (비-면역화된 대조군)으로부터의 돼지에서 부검시 점수화된 상이한 기관의 육안 병변을 보여주는 것이다.
도 12는 VP72/B646L 주요 캡시드 단백질을 기반으로, 상업적으로 이용가능한 경쟁 ELISA를 사용하여 측정된, 면역화 및 챌린지 동안 그룹 K 중의 돼지의 항체 반응 (적색 파선)을 보여주는 것이다.
도 13은 면역화 및 챌린지 동안 그룹 K에서의 세포 매개 면역 반응을 보여주는 것이다. 말초 혈액 단핵 세포를 면역화 이전, 부스트 및 챌린지에 수집하고, ASFV 유전자형 I Benin 97/1 (적색 막대) 또는 ASFV 유전자형 II Georgia 2007/1 (녹색 막대)로 자극하였다. IFN 감마 생산 세포의 개수를 Elispot 검정법에 의해 측정하였다
도 14는 시간 경과에 따른, Georgia 2007/1 분리주로의 자극 후의 상이한 돼지에 대한 IFN 감마 생산 세포의 개수를 보여주는 것이다.
도 15는 면역화 및 챌린지 후 상이한 시점 (일째) (x축)에 전혈 중에서 검출된 감염성 바이러스의 수준을 보여주는 것이다. 돼지 골수 세포 중 한계 희석에 의해 바이러스 역가를 측정하고, 형광에 의해 감염된 세포를 검출하고, y축 상에 TCID50/ml로 표시한다. 상이한 돼지에 대한 값은 도면 상에 표시된 바와 같이 상이한 색상으로 제시된다.
아프리카 돼지 열병 바이러스
아프리카 돼지 열병 바이러스 (ASFV)는 아프리카 돼지 열병 (ASF)의 병원체이다. ASFV의 게놈 구조는 문헌 [Chapman et al. 2008 J. Gen. Virol. 89: 397-408]에 설명되어 있는 바와 같이, 관련 기술분야에 공지되어 있다. ASFV는 적어도 150개의 유전자를 포함하는 선형 게놈을 가진 큰 20면체 이중-가닥 DNA 바이러스이다. 유전자 개수는 바이러스의 다른 분리주마다 약간씩 상이하다. ASFV는 다른 대형 DNA 바이러스, 예컨대, 폭스바이러스, 이리도바이러스 및 미미바이러스와 유사하다. 다른 바이러스성 출혈열과 마찬가지로, 복제의 주요 표적 세포는 단핵구, 대식세포 계통의 세포이다.
주요 캡시드 단백질 p72를 코딩하는 B646L 유전자의 C-말단 영역의 서열 변이에 기초하여, 22개의 ASFV 유전자형 (I-XXII)이 확인되었다. 모든 ASFV p72 유전자형은 동부 및 남부 아프리카에서 유행하고 있다. 유전자형 I은 유럽, 남미, 카리브해 및 서부 아프리카에서 유행하고 있다. 유전자형 II는 유럽 및 아시아의 여러 국가에서 유행하고 있다. 유전자형 IX는 여러 동아프리카 국가에 국한되어 있다.
일부 유전자형의 균주의 예는 하기에 제시되어 있다:
유전자형 I : OURT88/3; Brazil/79; Lisbon/60; BA715; Pret; Benin 97/1; IC/1/96; IC/576; CAM/82; Madrid/62; Malta/78; ZAR85; Katange63; Togo; Dakar59; Ourt88/1; BEN/1/97; Dom_Rep; VAL/76; IC/2/96; Awoshie/99; NIG/1/99; NIG/1/98; ANG/70; BEL/85; SPEC120; Lisbon/57; ASFV-Warm; GHA/1/00; GAM/1/00; Ghana; HOL/86; NAM/1/80; NUR/90/1; CAM/4/85; ASFV-Teng; Tegani; ASFV-E75.
유전자형 II: Georgia 2007/1; POL/2015/Podlaskie (폴란드 균주); Belgium/Etalle/wb/2018; ASFV/Kyiv/2016/131; China/2018/AnhuiXCGQ
유전자형 III: BOT 1/99
유전자형 IV: ASFV-War; RSA/1/99/W
유전자형 VI: MOZ 94/1
유전자형 VII: VICT/90/1; ASFV-Mku; RSA/1/98
유전자형 VIII: NDA/1/90; KAL88/1; ZAM/2/84; JON89/13; KAV89/1; DEZda; AFSV-Mal; Malawi LIL 20/1
유전자형 IX: UGA/1/95
유전자형 X: BUR/1/84; BUR/2/84; BUR/90/1; UGA/3/95; TAN/Kwh12; HindeII; ASFV-Ken; 병독성 Uganda 65.
한 실시양태에서, 본 발명의 ASF 바이러스는 약독화될 수 있다. 본 발명의 약독화된 ASF 바이러스는 임의의 조합으로 본원에 기재된 임의의 변형/돌연변이를 포함할 수 있다. 본원에 기재된 변형/돌연변이는 ASF 바이러스를 약독화시킬 수 있다.
ASFV 분리주
본 발명의 약독화된 ASF 바이러스는 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되도록 그의 게놈에 돌연변이를 포함함으로써, 야생형 ASF 바이러스 분리주로부터 유래가능하거나, 또는 유래된 것일 수 있다. 바이러스는 또한 예컨대, K145R 유전자의 발현을 파괴시키는 DIVA 돌연변이와 같은 DIVA 돌연변이를 포함할 수 있다.
"야생형"이라는 용어는 바이러스가 필드에 (어느 지점에) 존재했으며, 예컨대, 가축용 돼지, 진드기 또는 와트호그와 같은 천연 숙주에서 단리되었음을 나타낸다. 현재까지 기재된 ASFV 분리주는 진뱅크 수탁(Genbank Accession) 번호와 함께 하기 표 1에 요약되어 있다.
<표 1>
본 발명의 약독화된 ASFV의 게놈은 임의의 ASFV 유전자형에 상응할 수 있다. 본 발명의 약독화된 ASFV의 게놈은 본질적으로 임의의 ASFV 유전자형에 상응할 수 있다.
"~에 상응하는"이라는 용어는 본 발명의 약독화된 ASFV의 게놈의 나머지 부분이 야생형 균주(즉, 필드의 어느 지점에 존재했던 바이러스)와 동일하다는 것을 의미한다. "게놈의 나머지 부분"은 유전자 EP153R 및 EP402R 이외의 모든 다른 유전자를 지칭할 수 있다. "게놈의 나머지 부분"은 유전자 EP153R, EP402R 및 K145R 이외의 모든 다른 유전자를 지칭할 수 있다. 다시 말해, 본 발명의 약독화된 ASFV의 유전자는 본 발명에 따라 파괴되는 유전자를 제외하면, 야생형 균주의 유전자와 동일할 수 있다. 본 발명의 약독화된 ASFV의 유전자는 유전자 EP153R 및 EP402R을 제외하면, 야생형 균주의 유전자와 동일한 것일 수 있다. 본 발명의 약독화된 ASFV의 유전자는 유전자 EP153R, EP402R 및 K145R을 제외하면, 야생형 균주의 유전자와 동일한 것일 수 있다. 한 실시양태에서, 본 발명의 약독화된 ASFV의 유전자는 EP153R 및 EP402R을 제외하면, 야생형 균주의 유전자와 동일한 것이다. 한 실시양태에서, 본 발명의 약독화된 ASFV의 유전자는 EP153R, EP402R 및 K145R을 제외하면, 야생형 균주의 유전자와 동일한 것이다.
파괴된 유전자는 또한 야생형 균주에 상응할 수 있다. 한 실시양태에서, 유전자 EP153R 및 EP402R은 야생형 균주에 상응한다. 상기 실시양태에서 (즉, EP153R 및 EP402R이 야생형 균주에 상응하는 경우), EP153R 및 EP402R의 발현 및/또는 활성은 예컨대, 프로모터와 같은 유전자간 영역 및/또는 비-코딩 서열에서 하나 이상의 돌연변이에 의해 파괴될 수 있다. 다시 말해, EP153R 및 EP402R 유전자는 야생형 게놈과 동일하지만, 비유전자 서열의 돌연변이에 의해 발현 또는 활성이 변경된다. 따라서, 본 발명의 약독화된 ASFV의 유전자는 모두 야생형 균주의 유전자와 동일한 것일 수 있다. 한 실시양태에서, 본 발명의 약독화된 ASFV의 유전자는 모두 야생형 균주의 유전자와 동일한 것이다. 한 실시양태에서, 본 발명의 약독화된 ASFV의 유전자는 모두 K145R 유전자를 제외하면, 야생형 균주의 유전자와 동일한 것이다.
"본질적으로 ~에 상응하는"이라는 용어는 게놈의 나머지 부분이 하나 이상의 돌연변이를 포함할 수 있다는 추가적 예외를 제외하면, "~에 상응하는"과 동일한 것을 의미한다. 하나 이상의 돌연변이는 다른 유전자에 있을 수 있다 (즉, 유전자 EP153R 및 EP402R에는 없을 수 있거나, 또는 유전자 EP153R, EP402R 및 K145R에는 없을 수 있다).
약독화된 ASFV의 게놈은 유전자형 I에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 약독화된 ASFV의 게놈은 유전자형 II에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 약독화된 ASFV의 게놈은 유전자형 III에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 약독화된 ASFV의 게놈은 유전자형 IV에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 약독화된 ASFV의 게놈은 유전자형 V에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 약독화된 ASFV의 게놈은 유전자형 VI에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 약독화된 ASFV의 게놈은 유전자형 VII에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 약독화된 ASFV의 게놈은 유전자형 VIII에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 약독화된 ASFV의 게놈은 유전자형 IX에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 약독화된 ASFV의 게놈은 유전자형 X에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 약독화된 ASFV의 게놈은 유전자형 XIV에 상응하거나, 또는 본질적으로 그에 상응할 수 있다.
약독화된 ASFV의 게놈은 유전자형 I에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 약독화된 ASFV의 게놈은 유전자형 II에 상응하거나, 또는 본질적으로 그에 상응할 수 있다.
바람직하게, 약독화된 ASFV의 게놈은 유전자형 II에 상응하거나, 또는 본질적으로 그에 상응할 수 있다.
본 발명의 약독화된 ASFV의 게놈은 병독성 ASFV 균주의 것에 상응하거나, 또는 본질적으로 그에 상응할 수 있다. 공지된 병독성 ASF 바이러스 균주는 Georgia 2007/1, Benin 97/1, Kenyan, Malawi Lil20/1, Pretorisuskop/96/4 및 Tengani 62를 포함한다. 약독화된 ASFV의 게놈은 Benin 97/1 균주의 것에 상응하거나, 또는 본질적으로 그에 상응할 수 있다.
약독화된 ASFV의 게놈은 Georgia 2007/1 균주의 것에 상응하거나, 또는 본질적으로 그에 상응할 수 있다.
본 발명의 약독화된 ASFV의 게놈은 그의 병독성이 현재 공지되어 있지 않은 ASFV 균주, 예를 들어: Mkuzi, Warmbaths 및 Warthog의 것에 상응하거나, 또는 본질적으로 그에 상응할 수 있다.
한 실시양태에서, 본 발명의 약독화된 ASFV의 게놈은 OURT88/3의 것에 상응하지 않는다. 한 실시양태에서, 본 발명의 약독화된 ASFV의 게놈은 NH/P68의 것에 상응하지 않는다. 한 실시양태에서, 본 발명의 약독화된 ASFV는 OURT88/3이 아니다. 한 실시양태에서, 본 발명의 약독화된 ASFV는 NH/P68이 아니다. 한 실시양태에서, 본 발명의 약독화된 ASFV는 OURT88/3도 NH/P68도 아니다.
EP402R
특정 측면에서, 본 발명은 EP402R 유전자의 발현 및/또는 활성이 파괴된 ASF 바이러스를 제공한다.
다른 측면에서, 본 발명은 특정 아미노산 변이를 포함하는 EP402R 단백질을 제공한다.
EP402R 유전자는 바이러스의 외부 층에 혼입되고, 포유동물 T-림프구 표면 부착 수용체 CD2와 부분적으로 유사한 단백질을 코딩한다. 특히, EP402R 단백질의 N-말단 세포외 영역은 CD2의 세포외 리간드 결합 영역과 유사한 2개의 면역글로불린 유사 (Ig 유사) 도메인으로 이루어진다. EP402R 단백질은 이러한 유사성으로 인해 CD2v로 지칭될 수 있다. 따라서, 용어 "EP402R" 및 "CD2v"는 본원에서 상호교환적으로 사용될 수 있다. EP402R 단백질의 N-말단 세포외 도메인은 "리간드 결합 도메인"으로서 지칭될 수 있다. EP402R 단백질의 세포질 도메인은 CD2와 유사하지 않다.
EP402R은 면역원성이다 (즉, 면역 반응을 유발한다) (Netherton et al. 2019 Front. Immunol. 10, 1318). EP402R은 혈구흡착에 필요하고, 그에 직접적으로 관여하며 (Sereda et al. 2018 Slov. Vet. Res, 55(3) 141-150), 바이러스 진입 또는 확산에서 역할을 할 수 있다. 혈구흡착을 억제하는 ASFV 감염된 돼지로부터의 항체는 돼지 방어에서 EP402R에 대한 항체의 역할을 지원하는 다양한 균주에 대해 유도된 방어와 상관관계가 있을 수 있다 (Malogolovkin et al. 2015 J. Gen. Virol. 96(4) 866-873, Burmakina et al. 2016 J. Gen. Virol. 97(7) 1670-1675). EP402R은 숙주 단백질 AP-1에 결합할 수 있다. EP402R의 기능은 포유동물 CD2가 세포외 부착 분자에 결합하는 것과 동일한 방식으로 리간드에 결합하는 그의 세포외, N-말단, Ig 유사 도메인에 의해 매개될 수 있다.
EP402R
유전자 서열
상이한 ASFV 균주로부터의 EP402R 유전자의 게놈내 유전자 (즉, 뉴클레오티드) 서열 및 위치가 하기에 제시되어 있다.
한 실시양태에서, 본 발명은 EP402R 유전자의 발현 및/또는 활성이 파괴된 ASF 바이러스를 제공한다. 적합하게, EP402R 유전자는 서열식별번호 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240 또는 241의 서열을 포함한다. 적합하게, EP402R 유전자는 서열식별번호 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240 또는 241과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, EP402R 유전자는 서열식별번호 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240 또는 241의 서열로 이루어진다.
본 발명의 ASFV의 한 실시양태에서, EP402R 유전자는 부분적으로 또는 완전히 결실될 수 있다. 적합하게, 서열식별번호 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240 또는 241의 서열의 일부 또는 그들 모두는 ASFV 게놈으로부터 제거된다. 적합하게, ASFV 게놈에는 상기 서열 중 임의의 것이 결여되어 있다.
EP402R
단백질 서열
상이한 ASFV 균주로부터의 EP402R 단백질의 아미노산 서열이 하기에 서열식별번호 21 내지 30 및 서열식별번호 242 내지 246으로 제시되어 있다.
한 실시양태에서, 본 발명은 EP402R 유전자의 발현 및/또는 활성이 파괴된 약독화된 ASF 바이러스를 제공한다. 적합하게, EP402R 유전자는 서열식별번호 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 242, 243, 244, 245 또는 246 중 임의의 것과 적어도 70%, 75%, 80%, 85%, 90% 또는 95%의 동일성을 갖는 서열을 포함하는 단백질을 코딩한다. 적합하게, EP402R 유전자는 서열식별번호 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 242, 243, 244, 245 또는 246 중 임의의 것의 서열을 포함하는 단백질을 코딩한다.
한 실시양태에서, 본 발명의 ASFV는 EP402R 단백질을 발현하지 않는다. 다시 말해, 본 발명의 ASFV는 서열식별번호 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 242, 243, 244, 245 또는 246의 서열을 갖는 단백질을 발현하지 않는다.
EP402R
돌연변이체 단백질
한 측면에서, 본 발명은 리간드 결합 도메인 중 하나 이상의 아미노산 변이를 포함하는 EP402R 단백질로서, 여기서, 아미노산 변이는 EP402R 단백질의 리간드 결합을 파괴하는 것인 EP402R 단백질을 제공한다.
EP402R의 리간드 결합 도메인은 위치 1 (N-말단)에서 시작하여 대략 위치 200까지 이어지는 아미노산에 의해 형성된다. 예를 들어, 하기 서열식별번호 34로 제공되는 Benin 97/1 EP402R의 리간드 결합 도메인은 서열식별번호 21의 아미노산 1-198에 의해 형성된다.
하기 서열식별번호 380으로 제공되는 Georgia 2007/1 EP402R의 리간드 결합 도메인은 서열식별번호 24의 아미노산 1-203에 의해 형성된다.
적합하게, EP402R 단백질의 리간드 결합 도메인은 서열식별번호 34 또는 380의 서열을 포함한다. 적합하게, EP402R 단백질의 리간드 결합 도메인은 서열식별번호 34 또는 380과 적어도 70%, 80%, 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 다른 균주로부터의 EP402R 단백질의 리간드 결합 도메인은 예컨대, 도 3에 제시된 바와 같이, Benin 97/1 EP402R 단백질 및/또는 Georgia 2007/1 EP402R 단백질의 서열과의 정렬에 의해 쉽게 확인될 수 있다.
적합하게, 야생형 EP402R 단백질과 비교하여 EP402R 단백질의 리간드 결합 도메인 중의 하나 이상의 아미노산 (예컨대, 2개 이상, 3개 이상, 4개 이상 또는 5개 이상의 아미노산)이 변이된다. 한 실시양태에서, 리간드 결합 도메인 중 하나 이상의 아미노산이 결실된다 (즉, 완전히 제거된다). 한 실시양태에서, 리간드 결합 도메인 중 하나 이상의 아미노산이 상이한 아미노산으로 변이된다 (즉, 대체된다). 상기 아미노산 변이는 치환으로 지칭될 수 있다. EP402R 단백질의 리간드 결합 도메인 중 하나 이상의 아미노산의 변이는 EP402R 단백질의 발현 및/또는 활성을 파괴시킬 수 있다. 한 실시양태에서, EP402R 단백질의 리간드 결합 도메인 중 하나 이상의 아미노산의 변이는 EP402R 단백질에 의해 매개되는 혈구흡착을 파괴시킬 수 있다.
EP402R 단백질 중 아미노산 변이는 EP402R 단백질을 코딩한 서열 중 하나 이상의 돌연변이에 의해 유발된다. 한 실시양태에서, 하나 이상의 돌연변이는 본원에 기재된 바와 같은 결실 또는 중단일 수 있다. 예를 들어, EP402R 단백질의 리간드 결합 도메인에 대한 코딩 서열의 일부가 결실되면 리간드 결합 도메인으로부터 코딩된 아미노산이 부재하게 되며 (즉, 아미노산 변이), 이는 리간드 결합을 파괴시킬 수 있다.
한 실시양태에서, 돌연변이 중 하나 이상은 점 돌연변이일 수 있다. 적합하게, 돌연변이 중 하나 이상은 단일 아미노산을 상이한 아미노산으로 변이시키는 점 돌연변이일 수 있다. 심지어 단일 아미노산 변이만으로도 EP402R 단백질의 발현 및/또는 활성, 예컨대, 리간드 결합 활성은 파괴될 수 있다.
하나 이상의 아미노산 변이는 EP402R 단백질의 폴딩을 파괴시킬 수 있다. 폴딩 파괴는 EP402R 단백질이 전혀 폴딩하지 못함에 따라 이는 세포 단백질 분해 기계에 의해 분해된다는 것을 의미할 수 있다. 대안적으로, 폴딩 파괴는 EP402R 단백질이 다르게 폴딩되어 그의 기능을 손상시키거나, 또는 EP402R 단백질이 더 천천히 폴딩됨에 따라 올바르게 발현되지 않다는 것 (예컨대, 세포 표면에서 발현되지 않는다는 것)을 의미할 수 있다.
하전된 아미노산의 반대 전하를 갖는 아미노산으로의 변이는 EP402R 리간드-도메인의 폴딩을 파괴할 수 있으며, 이로써, 결합 포켓이 변형되고, 이는 입체 장애로 인한 리간드 결합을 방해할 수 있다. 대안적으로 또는 추가로, 반대 전하를 갖는 아미노산으로의 치환은 리간드의 정전기적 결합을 방해할 수 있다. 또 다른 가능성은 작은 측쇄가 있는 아미노산의 벌키한 측쇄가 있는 아미노산으로의 변이, 또는 그 반대로 이루어지는 변이는 EP402R 리간드 결합 도메인의 폴딩을 파괴할 수 있으며, 이로써, 결합 포켓이 형성되지 않고, 이는 리간드 결합을 방해한다.
따라서, 한 실시양태에서, 리간드 결합 도메인 중 하나 이상의 변이된 아미노산은 양으로 하전된 아미노산으로 변이되는 음으로 하전된 아미노산을 포함할 수 있다. 한 실시양태에서, 리간드 결합 도메인 중 하나 이상의 변이된 아미노산은 음으로 하전된 아미노산으로 변이되는 양으로 하전된 아미노산을 포함할 수 있다. 양으로 하전된 아미노산 (즉, 양전하를 가질 수 있는 아미노산)은 히스티딘 (H), 리신 (K) 및 아르기닌 (R)을 포함한다. 음으로 하전된 아미노산 (즉, 음전하를 가질 수 있는 아미노산)은 아스파르트산 (D) 및 글루탐산 (E)을 포함한다.
한 실시양태에서, 리간드 결합 도메인 중 하나 이상의 변이된 아미노산은 벌키한 측쇄가 있는 아미노산으로 변이되는 작은 측쇄가 있는 아미노산을 포함할 수 있다. 한 실시양태에서, 리간드 결합 도메인 중 하나 이상의 변이된 아미노산은 작은 측쇄가 있는 아미노산으로 변이되는 벌키한 측쇄가 있는 아미노산을 포함할 수 있다. 벌키한 측쇄가 있는 아미노산은 트립토판 (W)을 포함한다. 작은 측쇄가 있는 아미노산은 글리신 (G) 및 알라닌 (A)을 포함한다.
한 실시양태에서, 리간드 결합 도메인 중 하나 이상의 변이된 아미노산은 소수성 측쇄가 있는 아미노산으로 변이되는 친수성 측쇄가 있는 아미노산을 포함할 수 있다. 한 실시양태에서, 리간드 결합 도메인 중 하나 이상의 변이된 아미노산은 친수성 측쇄가 있는 아미노산으로 변이되는 소수성 측쇄가 있는 아미노산을 포함할 수 있다. 소수성 측쇄가 있는 아미노산은 알라닌 (A), 발린 (V), 이소류신 (I), 류신 (L), 메티오닌 (M), 페닐알라닌 (F), 티로신 (Y) 및 트립토판 (W)을 포함한다. 친수성 측쇄가 있는 아미노산은 아르기닌 (R), 히스티딘 (H), 리신 (K), 아스파르트산 (D), 글루탐산 (E), 세린 (S), 트레오닌 (T), 아스파라긴 (N) 및 글루타민 (Q)을 포함한다.
아미노산 E99의 R로의 변이, 또는 아미노산 Y102의 D로의 변이는 Benin 97/1 균주로부터의 EP402R 단백질의 혈구흡착을 매개하는 능력을 파괴시킨다 (도 2 참조). 추가로, 아미노산 Q96의 R로의 변이는 Georgia 2007/1 균주로부터의 EP402R 단백질의 혈구흡착을 매개하는 능력을 파괴시킨다 (도 4 및 7 참조). Georgia 2007/1 EP402R의 아미노산 W99의 D로의 변이는 EP402R의 폴딩을 파괴시킬 수 있고, 이로써, 발현 및/또는 활성이 파괴될 수 있다. 따라서, 한 실시양태에서, 본 발명의 EP402R 단백질은 Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96 및/또는 W99에 상응하는 위치에 아미노산 변이를 포함한다. Georgia 2007/1 EP402R 단백질의 Q96은 Benin 97/1 EP402R 단백질의 E99에 상응하고, Georgia 2007/1 EP402R 단백질의 W99는 Benin 97/1 EP402R 단백질의 Y102에 상응한다. 따라서, 한 실시양태에서, 본 발명의 EP402R 단백질은 Benin 97/1 EP402R 단백질 (서열식별번호 21)의 E99 및/또는 Y102에 상응하는 위치에 아미노산 변이를 포함한다. 다시 말해, 본 발명의 약독화된 ASF 바이러스에 의해 발현된 EP402R 단백질은 임의의 ASF 바이러스 균주로부터의 EP402R 단백질일 수 있으며, 변이된 아미노산은 본원에서 서열식별번호 24로서 제공되는 Georgia 2007/1 EP402R 단백질의 아미노산 서열의 Q96 및/또는 W99에 상응한다. 대안적으로 표현하면, 본 발명의 약독화된 ASF 바이러스에 의해 발현된 EP402R 단백질은 임의의 ASF 바이러스 균주로부터의 EP402R 단백질일 수 있으며, 변이된 아미노산은 본원에서 서열식별번호 21로서 제공되는 Benin 97/1 균주로부터의 EP402R 단백질의 아미노산 서열의 E99 및/또는 Y102에 상응한다. 위치 Q96 및 W99는 각각 Georgia 2007/1 EP402R 단백질의 위치 96 및 99의 아미노산 글루타민 및 트립토판을 지칭한다. 위치 E99 및 Y102는 각각 Benin 97/1 EP402R 단백질의 위치 99 및 102의 아미노산 글루탐산 및 티로신을 지칭한다.
아미노산이 Georgia 2007/1 EP402R 단백질의 Q96 및/또는 W99에 (또는 Benin 97/1 EP402R 단백질의 E99 및/또는 Y102에) 상응하는지 여부는 서열 정렬에 의해 평가될 수 있다. 예를 들어, 도 3은 Benin, Mkuzi, Warmbaths, Tengnani, Warthog, Georgia 및 Malawi 균주로부터의 EP402R 단백질의 정렬을 보여주는 것이다. Georgia 2007/1 EP402R 단백질의 Q96 및 Benin 97/1 EP402R 단백질의 E99에 상응하는, 각 균주로부터의 EP402R 단백질 중의 아미노산은 Benin E99 잔기 아래 제시된 아미노산 (황색으로 강조 표시)이다. Georgia 2007/1 EP402R 단백질의 W99 및 Benin 97/1 EP402R 단백질의 Y102에 상응하는, 각 균주로부터의 EP402R 단백질 중의 아미노산은 Benin Y102 잔기 아래 제시된 아미노산 (황색으로 강조 표시된 아미노산의 우측으로 3개의 아미노산). Georgia 2007/1 EP402R 단백질의 Q96 및/또는 W99, 및 Benin 97/1 EP402R 중 E99 및 Y102에 상응하는 도 3에서 상기 균주로부터의 EP402R 단백질 중의 아미노산은 하기 표 2에 제시되어 있다.
<표 2>
Georgia 2007/1 EP402R 단백질의 Q96 및/또는 W99, 및 Benin 97/1 EP402R의 E99 및 Y102에 상응하는 아미노산은 도 3에 제시되고, 상기 표 2에 열거된 것 이외의 다른 균주 (예컨대, 본원 표 1에 열거된 다른 균주)로부터의 EP402R 단백질에 존재한다. 통상의 기술자는 서열 정렬을 사용하여 주어진 균주, 예컨대, 표 1로부터의 균주로부터의 EP402R 단백질 중의 어느 아미노산이 Georgia 2007/1 EP402R 단백질의 Q96 및/또는 W99, 및 Benin 97/1 EP402R의 E99 또는 Y102에 상응하는지를 쉽게 결정할 수 있다. 상응하는 아미노산은 Georgia 2007/1 EP402R의 Q96 또는 W99, 또는 Benin 97/1 EP402R의 E99 또는 Y102와 동일할 수 있다. 예를 들어, Georgia 2007/1 EP402R의 Q96에 상응하는 아미노산은 또한 Q (글루타민)일 수 있다. 상응하는 아미노산은 Q96 또는 W99와 유사할 수 있다. 적합하게, 상응하는 아미노산은 Q96 또는 W99와 동일한 전하를 갖는다. 적합하게, Q96에 상응하는 아미노산은 E (글루탐산)이다. 적합하게, W99에 상응하는 아미노산은 Y (티로신)이다. "Georgia 2007/1 EP402R 단백질의 Q96 및/또는 W99에 상응하는"이라는 표현은 Georgia 2007/1 EP402R 단백질의 Q96 및/또는 W99를 포함한다. "Benin 97/1 EP402R 단백질의 E99 및/또는 Y102에 상응하는"이라는 표현은 Benin 97/1 EP402R 단백질의 E99 및/또는 Y102를 포함한다.
적합하게, Q96에 상응하는 위치의 아미노산은 R로, 또는 R의 보존적 대체인 아미노산으로 변이되고/거나, W99에 상응하는 위치의 아미노산은 D로, 또는 D의 보존적 대체인 아미노산으로 변이된다. "보존적 대체"인 아미노산은 다른 아미노산과 유사한 특징을 갖는다. 예를 들어, 보존적 대체는 유사한 전하 (양 또는 음), 유사한 소수성 (친수성 또는 소수성) 또는 유사한 분자 크기를 가질 수 있고, 또한 방향족이거나, 또는 상기 특징의 조합을 가질 수 있다. 적합하게, Q96에 상응하는 위치의 아미노산은 H, K 또는 R로 변이되고/거나, W99에 상응하는 위치의 아미노산은 D, E, N 또는 Q로 변이된다. 적합하게, Q96에 상응하는 위치의 아미노산은 R로 변이되고/거나, W99에 상응하는 위치의 아미노산은 D로 변이된다.
한 실시양태에서, 본 발명의 EP402R 단백질은 서열식별번호 21 내지 30 또는 서열식별번호 242 내지 246 (즉, 본원에 기재된 바와 같은 상이한 ASFV 균주로부터의 EP402R 단백질의 서열) 중 임의의 것과 적어도 70%의 서열 동일성, 예컨대, 적어도 75%의 동일성, 예컨대, 적어도 80%의 동일성, 예컨대, 적어도 85%의 동일성, 예컨대, 적어도 90%의 동일성, 예컨대, 적어도 95%의 동일성, 예컨대, 적어도 96%의 동일성, 예컨대, 적어도 97%의 동일성, 예컨대, 적어도 98%의 동일성, 예컨대, 적어도 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 21과 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 22와 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 23과 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 24와 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 25와 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 26과 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 27과 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 28과 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 29와 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 30과 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 242와 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 243과 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 244와 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 245와 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 246과 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 아미노산 서열을 포함한다.
특정 실시양태에서, 기준 서열 (즉, 서열식별번호 21 내지 30 또는 서열식별번호 242 내지 246)과, 기준 서열과 100% 미만으로 동일한 서열 사이에 상이한 아미노산이 보존적 대체이다.
E99R 아미노산 변이를 포함하는 Benin 97/1 균주로부터의 EP402R 단백질의 아미노산 서열은 하기 서열식별번호 31로서 제시되어 있다.
Y102D 치환을 포함하는 Benin 97/1 균주로부터의 EP402R 단백질의 아미노산 서열은 하기 서열식별번호 32로서 제시되어 있다.
Q96R 치환을 포함하는 Georgia 2007/1 균주로부터의 EP402R 단백질의 아미노산 서열은 하기 서열식별번호 33으로서 제시되어 있다.
W99D 치환을 포함하는 Georgia 2007/1 균주로부터의 EP402R 단백질의 아미노산 서열은 하기 서열식별번호 379로서 제시되어 있다.
한 실시양태에서, 본 발명의 EP402R 단백질은 서열식별번호 31, 32, 33 또는 379 중 임의의 것의 아미노산 서열을 포함한다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 31 (E99R 아미노산 변이를 갖는 Benin 97/1 EP402R 단백질)의 아미노산 서열을 포함하거나, 또는 그로 이루어진다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 32 (Y102D 아미노산 변이를 갖는 Benin 97/1 EP402R 단백질)의 아미노산 서열을 포함하거나, 또는 그로 이루어진다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 33 (Q96R 아미노산 변이를 갖는 Georgia 2007/1 EP402R 단백질)의 아미노산 서열을 포함하거나, 또는 그로 이루어진다. 적합하게, 본 발명의 EP402R 단백질은 서열식별번호 379 (W99D 아미노산 변이를 갖는 Georgia 2007/1 EP402R 단백질)의 아미노산 서열을 포함하거나, 또는 그로 이루어진다.
한 실시양태에서, 본 발명의 EP402R 단백질은 Benin 97/1 EP402R 단백질 (서열식별번호 21)의 N16, I19, W21, Y76, E99, Y102 및/또는 N108에 상응하는 EP402R 단백질 중의 위치에 하나 이상의 아미노산 변이를 포함한다. 한 실시양태에서, 하나 이상의 돌연변이는 Benin 97/1 균주의 EP402R 단백질의 위치 N16, I19, W21, Y76, E99, Y102 및/또는 N108, 또는 임의의 다른 ASFV 균주의 EP402R 단백질 중의 상응하는 위치의 아미노산을 변이시킨다. 한 실시양태에서, 하나 이상의 돌연변이는 Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 S15, W19, Q96, N104, 및/또는 K108D에 상응하는 EP402R 단백질 중의 위치의 아미노산을 변이시킨다. 한 실시양태에서, 하나 이상의 돌연변이는 Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 EP402R 단백질의 위치 S15, W19, Q96, N104, 및/또는 K108D, 또는 임의의 다른 ASFV 균주의 EP402R 단백질 중의 상응하는 위치의 아미노산을 변이시킨다. 한 실시양태에서, 하나 이상의 돌연변이는 N10 유전자형 IX EP402R 단백질 (서열식별번호 27)의 W20, Q112, N121 및/또는 R125에 상응하는 EP402R 단백질 중의 위치의 아미노산을 변이시킨다. 한 실시양태에서, 하나 이상의 돌연변이는 N10 유전자형 IX EP402R 단백질 (서열식별번호 27)의 EP402R 단백질의 위치 S15, W19, Q96, N104, 및/또는 K108D, 또는 임의의 다른 ASFV 균주의 EP402R 단백질 중의 상응하는 위치의 아미노산을 변이시킨다. 상기 아미노산은 EP402R 단백질의 리간드 결합 도메인 중에 존재하고, 표면 노출되어 있다.
적합하게, 돌연변이는 Benin 97/1 EP402R 단백질 (서열식별번호 11) 중의 위치에 상응하는 위치의 N16R, I19R, W21D, Y 76D, E99R, Y102D 및/또는 N108R로부터 선택된다. 적합하게, 돌연변이는 Georgia 2007/1 EP402R 단백질 (서열식별번호 11) 중의 위치에 상응하는 위치의 E99R 및 N108R의 조합이다.
적합하게, 돌연변이는 Georgia 2007/1 EP402R 단백질 (서열식별번호 24) 중의 위치에 상응하는 위치의 S15R, W19D, Q96R, N104R 및/또는 K108D로부터 선택된다. 적합하게, 돌연변이는 Georgia 2007/1 EP402R 단백질 (서열식별번호 24) 중의 위치에 상응하는 위치의 Q96R 및 N104R의 조합이다.
적합하게, 돌연변이는 N10 유전자형 IX EP402R 단백질 (서열식별번호 27) 중의 위치에 상응하는 위치의 W20D, Q112R, N121R 및/또는 R125D로부터 선택된다. 적합하게, 돌연변이는 N10 유전자형 IX EP402R 단백질 (서열식별번호 27) 중의 위치에 상응하는 위치의 Q112R 및 N121R의 조합이다.
적합하게, 약독화된 ASFV가 유전자형 I인 경우, 하나 이상의 돌연변이는 Benin 97/1 EP402R 단백질 (서열식별번호 11)의 Y76, E99, Y102, 및/또는 N108에 상응하는, EP402R 단백질 중의 위치의 아미노산을 변이시킨다. 적합하게, 약독화된 ASFV가 유전자형 I인 경우, 돌연변이는 Benin 97/1 EP402R 단백질 (서열식별번호 11) 중의 위치에 상응하는 위치의 Y76D, E99R, Y102D, 및/또는 N108R로부터 선택된다.
적합하게, 약독화된 ASFV가 유전자형 II인 경우, 하나 이상의 돌연변이는 Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 S15, W19, Q96, N104, 및/또는 K108D에 상응하는, EP402R 단백질 중의 위치의 아미노산을 변이시킨다. 적합하게, 약독화된 ASFV가 유전자형 II인 경우, 돌연변이는 Georgia 2007/1 EP402R 단백질 (서열식별번호 24) 중의 위치에 상응하는 위치의 S15R, W19D, Q96R, N104R 및/또는 K108D로부터 선택된다. 적합하게, 약독화된 ASFV가 유전자형 II인 경우, 돌연변이는 Georgia 2007/1 EP402R 단백질 (서열식별번호 24) 중의 위치에 상응하는 위치의 Q96R 및 N104R의 조합일 수 있다.
본 발명은 또한 본 발명의 EP402R 단백질을 코딩하는 폴리뉴클레오티드를 제공한다. 적합하게, 폴리뉴클레오티드는 서열식별번호 229 내지 241 중 임의의 것 (즉, ASFV의 상이한 균주로부터의 EP402R 유전자의 코딩 서열)과 적어도 70%의 동일성, 예컨대, 적어도 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 서열을 포함한다. 적합하게, 폴리뉴클레오티드는 서열식별번호 229 (즉, Georgia 2007/1 EP402R 유전자의 코딩 서열)과 적어도 70%의 동일성, 예컨대, 적어도 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% 또는 99%의 동일성을 갖는 서열을 포함한다.
본 발명은 또한 본 발명의 폴리뉴클레오티드를 포함하는 벡터를 제공한다. 적합한 벡터는 관련 기술분야에 공지되어 있으며, 세포, 예컨대, 관련 기술분야에 공지된 다른 세포 유형 중에서 박테리아, 효모 또는 척추동물 세포, 또는 관련 기술분야에 공지된 다른 세포 유형에서에서 단백질 발현을 위한 플라스미드를 포함한다.
돌연변이된
EP402R을
포함하는
ASF
바이러스
또 다른 측면에서, 본 발명은 예컨대, 상기 기재된 바와 같은, 본 발명의 EP402R 단백질을 포함하는 ASF 바이러스를 제공한다. 유사한 측면에서, 본 발명은 예컨대, 상기 기재된 바와 같은, 본 발명의 폴리뉴클레오티드를 포함하는 ASF 바이러스를 제공한다. 또 다른 측면에서, 본 발명은 본원에 기재된 바와 같은 약독화된 ASF 바이러스로서, 여기서, 바이러스는 본 발명의 EP402R 단백질, 예컨대, 상기 기재된 EP402R 단백질을 발현하도록 돌연변이된 EP402R 유전자를 포함하는 것인, 약독화된 ASF 바이러스를 제공한다.
통상의 기술자는 본 개시내용으로부터 관련 기술분야에 공지된 분자 생물학 기술을 사용하여 EP402R 유전자의 코딩 서열을 적절하게 변형시킴으로써 본원에 기재된 임의의 아미노산 변이를 포함하는 EP402R 단백질을 발현하도록 ASF 바이러스가 돌연변이될 수 있다는 것을 이해할 것이다. 따라서, 본 발명은 본원에 개시된 본 발명의 임의의 EP402R 단백질을 포함하는 ASF 바이러스를 포함한다. 추가로, 통상의 기술자는 본원에 기재된 임의의 EP402R 단백질이 본원에 기재된 ASF 바이러스에 대한 다른 변형, 특히, K145R 및 EP153R 유전자의 변형과 함께 본 발명의 ASF 바이러스에서 조합될 수 있다는 것을 인식할 것이다. 추가로, 본 발명의 아미노산 변이를 포함하는 EP402R 단백질을 포함하는 본 발명의 ASFV는 약독화될 수 있다.
본 발명의 ASF 바이러스의 한 실시양태에서, EP402R 유전자는 EP402R 단백질의 리간드 결합 도메인 중 하나 이상의 아미노산을 변이시키는 하나 이상의 돌연변이를 포함한다. 적합하게, EP402R 유전자는 EP402R 단백질의 리간드 결합 도메인 중 하나 이상의 아미노산 (예컨대, 2개 이상, 3개 이상, 4개 이상 또는 5개 이상의 아미노산)을 변이시키는 하나 이상의 돌연변이 (예컨대, 2개 이상, 3개 이상, 4개 이상 또는 5개 이상의 돌연변이)를 포함한다.
본 발명의 ASF 바이러스의 실시양태에서, ASF 바이러스는 본원에 기재된 임의의 방식으로 EP402R 단백질 중 하나 이상의 아미노산을 변이시키는 하나 이상의 돌연변이를 EP402R 유전자 중에 포함한다. 예를 들어, 한 실시양태에서, EP402R 유전자 중의 하나 이상의 돌연변이는 Georgia 2007/1 균주의 EP402R 단백질의 위치 Q96 및/또는 W99, 또는 임의의 다른 ASFV 균주의 EP402R 단백질 중의 상응하는 위치의 아미노산을 변이시킨다. 한 실시양태에서, EP402R 유전자 중의 하나 이상의 돌연변이는 Georgia 2007/1 균주 (서열식별번호 24)의 EP402R 단백질의 위치 Q96의 아미노산을 R로 변이시킨다.
EP402R의
활성
본 발명의 ASFV의 한 실시양태에서, EP402R 활성은 파괴된다.
한 실시양태에서, 파괴되는 EP402R의 활성은 혈구흡착을 매개하는 그의 능력이다. 다시 말해, 혈구흡착을 매개하는 EP402R의 능력은 감소될 수 있다. 혈구흡착을 매개하는 EP402R의 능력은 적어도 50, 60, 70, 80 또는 90%만큼 감소될 수 있다. 혈구흡착을 매개하는 EP402R의 능력은 완전히 폐기될 수 있다.
파괴되는 EP402R의 활성은 EP402R 단백질이 그의 세포외 N-말단 Ig 유사 도메인 (즉, 그의 리간드 결합 도메인)을 통해 리간드에 결합하는 능력일 수 있다. 따라서, 본 실시양태에서, 본 발명은 EP402R 유전자가 EP402R 단백질에 의한 리간드 결합을 파괴하는 하나 이상의 돌연변이를 포함하는 것인 약독화된 ASF 바이러스를 제공한다. 하나 이상의 리간드에 결합할 수 있는 EP402R 단백질의 능력은 파괴될 수 있다. 하나 이상의 리간드에 결합할 수 있는 EP402R 단백질의 능력은 적어도 50, 60, 70, 80 또는 90%만큼 감소될 수 있다. 하나 이상의 리간드에 결합할 수 있는 EP402R 단백질의 능력은 완전히 폐기될 수 있다. 하나 이상의 리간드에 결합할 수 있는 EP402R 단백질의 능력은, 다른 리간드에 결합할 수 있는 능력은 보유하면서, 완전히 폐기될 수 있다. 한 실시양태에서, 본 발명은 EP402R 유전자가 EP402R 단백질에 의한 리간드 결합을 파괴하는 하나 이상의 돌연변이를 포함하는 것인 약독화된 ASF 바이러스를 제공한다. 리간드 결합은 예컨대, 면역침전, 표면 플라즈몬 공명 및/또는 등온 열량측정법과 같은 검정법을 사용하여 측정할 수 있다.
한 실시양태에서, 본 발명은 EP402R 단백질에서 변이된 아미노산이 본원에 기재된 바와 같이 EP402R 상의 결합 표면을 변경함으로써 EP402R과 그의 리간드 사이의 상호작용을 직접 억제하는 것인 ASF 바이러스를 제공한다.
한 실시양태에서, 본 발명은 EP402R 유전자의 발현 및/또는 활성이 파괴되지 않은 상응하는 ASF 바이러스와 비교하여 EP402R 단백질의 표면 발현이 감소된 ASF 바이러스를 제공한다. EP402R의 "표면 발현"은 ASF 바이러스에 감염된 세포의 표면에서의 EP402R 단백질의 발현을 지칭한다. EP402R의 표면 발현은 예컨대, 감염된 세포의 항체 염색과 같은 관련 기술분야에 공지된 기술에 의해 측정될 수 있다 (예를 들어, 도 8 및 실시예 3 참조).
EP153R
특정 측면에서, 본 발명은 EP153R 유전자의 발현 및/또는 활성이 파괴된 ASF 바이러스를 제공한다.
EP153R 유전자는 감염 초기 및 후기, 둘 모두에서 발현된다. EP153R은 8CR로도 지칭될 수 있다. EP153R 단백질은 C형 렉틴이다. C형 동물 렉틴은 혈청, 세포외 기질 및 세포막에서 발견되며, 탄수화물 리간드에 대한 수용체로 작용하는 것으로 간주된다. EP153R 단백질은 C형 렉틴 도메인, 세포 부착 서열 (RGD) 및 막횡단 도메인을 포함하며, T 세포 활성화에 관여하는 CD44 분자와 유사성을 갖는다.
상이한 ASFV 균주로부터의 EP153R 유전자의 게놈내 유전자 (즉, 뉴클레오티드) 서열 및 위치가 하기에 제시되어 있다.
한 실시양태에서, 본 발명은 EP153R 유전자의 발현 및/또는 활성이 파괴된 ASF 바이러스를 제공한다. 적합하게, EP153R 유전자는 서열식별번호 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215 또는 216의 서열을 포함한다. 적합하게, EP153R 유전자는 서열식별번호 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215 또는 216과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, EP153R 유전자는 서열식별번호 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215 또는 216의 서열로 이루어진다.
본 발명의 ASFV의 한 실시양태에서, EP153R 유전자는 부분적으로 또는 완전히 결실될 수 있다. 적합하게, 서열식별번호 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215 또는 216의 서열의 일부 또는 그들 모두는 ASFV 게놈으로부터 제거된다. 적합하게, ASFV 게놈에는 상기 서열 중 임의의 것이 결여되어 있다.
ASFV의 상이한 균주로부터의 EP153R 단백질의 수탁 번호는 하기 표 3에 열거되어 있다.
<표 3>
상이한 ASFV 균주로부터의 EP153R 단백질의 아미노산 서열이 하기 제시되어 있다.
적합하게, EP153R 유전자는 서열식별번호 20, 217, 218, 219, 220, 221, 222, 223, 224, 225 226, 227 또는 228의 서열을 포함하는 단백질을 코딩한다. 적합하게, EP153R 유전자는 서열식별번호 20, 217, 218, 219, 220, 221, 222, 223, 224, 225 226, 227 또는 228과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함하는 단백질을 코딩한다. 적합하게, EP153R 유전자는 서열식별번호 20, 217, 218, 219, 220, 221, 222, 223, 224, 225 226, 227 또는 228의 서열로 이루어진 단백질을 코딩한다.
한 실시양태에서, 본 발명의 ASFV는 EP153R 단백질을 발현하지 않는다. 다시 말해, 본 발명의 ASFV는 서열식별번호 20, 217, 218, 219, 220, 221, 222, 223, 224, 225 226, 227 또는 228의 서열을 갖는 단백질을 발현하지 않는다.
EP153R은 면역원성이다 (즉, 면역 반응을 유발한다) (Burmakina et al. 2019 J. Gen. Virol. 100: 259-265). EP153R은 ASFV 감염 동안 카스파제-3 활성화를 억제하여 아폽토시스를 억제하는 효과가 있다. EP153R은 혈구흡착에 필요하다. EP153R은 또한 감염된 세포에서 MHC-I 발현을 억제한다.
EP153R의
활성
본 발명의 약독화된 ASFV의 한 실시양태에서, EP153R 활성은 파괴될 수 있다.
한 실시양태에서, 파괴될 수 있는 EP153R의 활성은 혈구흡착을 매개하는 그의 능력이다. 다시 말해, 혈구흡착을 매개하는 EP153R의 능력은 감소될 수 있다. 혈구흡착을 매개하는 EP153R의 능력은 적어도 50, 60, 70, 80 또는 90%만큼 감소될 수 있다. 혈구흡착을 매개하는 EP153R의 능력은 완전히 폐기될 수 있다.
한 실시양태에서, 파괴될 수 있는 EP153R의 활성은 카스파제-3을 억제하는 그의 능력이다. 다시 말해, 카스파제-3을 억제하는 EP153R의 능력은 감소될 수 있다. 카스파제-3을 억제하는 EP153R의 능력은 적어도 50, 60, 70, 80 또는 90%만큼 감소될 수 있다. 카스파제-3을 억제하는 EP153R의 능력은 완전히 폐기될 수 있다. 카스파제-3 활성은 예컨대, 후르타도(Hurtado) 등에 의해 기재된 바와 같이 (Hurtado et al. 2004 Virology 326: 160-170), 관련 기술분야에 공지된 검정법에 의해 측정될 수 있다. 예를 들어, 17 kDa의 절단된 활성 카스파제-3 단편 및 34 kDa의 불활성 프로카스파제-3 단백질을 웨스턴 블롯 또는 질량 분석법을 사용하여 정량화하고, 비교하여 카스파제-3의 활성화 정도를 확인할 수 있다. 대안적으로 또는 추가로, 형광 기질을 절단할 수 있는 세포 추출물 중의 카스파제-3의 능력을 고성능 액체 크로마토그래피를 사용하여 측정할 수 있다.
한 실시양태에서, 파괴될 수 있는 EP153R의 활성은 MHC-I 발현을 억제하는 그의 능력이다. 다시 말해, MHC-I 발현을 억제하는 EP153R의 능력은 감소될 수 있다. MHC-I 발현을 억제하는 EP153R의 능력은 적어도 50, 60, 70, 80 또는 90%만큼 감소될 수 있다. MHC-I 발현을 억제하는 EP153R의 능력은 완전히 폐기될 수 있다. MHC-I 발현은 예컨대, 후르타도 등에 의해 기재된 바와 같이 (Hurtado et al. 2011 Arch. Virol. 156(2): 219-234), 관련 기술분야에 공지된 검정법에 의해 측정될 수 있다. 예를 들어, MHC-I의 세포 표면 발현은 투과되지 않은 세포의 항체 염색 후 유세포 분석법을 사용하여 측정할 수 있다.
DIVA 돌연변이
한 실시양태에서, 본 발명의 ASFV는 백신접종받은 동물로부터의 감염된 동물 감별 (DIVA) 돌연변이를 포함한다. DIVA 돌연변이는 ASF 바이러스를 포함하는 백신이 DIVA 백신으로 작용할 수 있게 하는 ASF 바이러스의 돌연변이이다 (즉, DIVA 백신으로 백신접종받은 대상체는 야생형 ASF 바이러스로 감염된 대상체로부터 감별될 수 있다).
한 실시양태에서, 본 발명은 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고; 하기 유전자:
다중유전자 패밀리 (MGF) 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L,
MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R, 및
MGF 505 1R, 2R 및 6R 중 하나 이상의 기능성 버전을 포함하고;
DIVA 돌연변이를 포함하는 것인, 약독화된 ASF 바이러스를 제공한다.
한 실시양태에서, 본 발명은 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고; 하기 유전자:
다중유전자 패밀리 (MGF) 110 11L 및 12L,
MGF 360 6L, 10L, 11L, 12L, 13L, 및 14L, 및
MGF 505 1R 및 2R 중 하나 이상의 기능성 버전을 포함하고;
DIVA 돌연변이를 포함하는 것인, 약독화된 ASF 바이러스를 제공한다.
한 실시양태에서, 본 발명은 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고; 하기 유전자:
다중유전자 패밀리 (MGF) 110 5L, 6L, 8L 및 12L,
MGF 360 6L, 10L, 11L, 12L, 13L, 14L 및 21R, 및
MGF 505 1R 및 2R 중 하나 이상의 기능성 버전을 포함하고;
DIVA 돌연변이를 포함하는 것인, 약독화된 ASF 바이러스를 제공한다.
한 실시양태에서, 본 발명은 리간드 결합 도메인 중에 하나 이상의 아미노산 변이를 포함하는 EP402R 단백질로, 여기서, 아미노산 변이는 EP402R 단백질의 리간드 결합을 파괴시키는 것인 EP402R 단백질 (즉, 본 발명의 EP402 단백질), 및/또는 상기 EP402R 단백질을 코딩하는 폴리뉴클레오티드를 포함하고, DIVA 돌연변이를 추가로 포함하는 ASF 바이러스를 제공한다.
한 실시양태에서, DIVA 돌연변이는 K145R 유전자 및/또는 B125R 유전자의 발현을 파괴시킨다. 적합하게, DIVA 돌연변이는 K145R 유전자의 발현을 파괴시킨다. 적합하게, K145R 유전자는 부분적으로 결실된다. 적합하게, K145R 유전자는 완전히 결실된다. 적합하게, B125R 유전자는 부분적으로 결실된다. 적합하게, B125R 유전자는 완전히 결실된다.
K145R
K145R 유전자는 후기 유전자이다.
상이한 ASFV 균주로부터의 K145R 유전자의 유전자 (즉, 뉴클레오티드) 서열이 하기에 제시되어 있다.
한 실시양태에서, 본 발명의 ASFV는 K145R 유전자의 발현을 파괴시키는 DIVA 돌연변이를 포함한다. 다시 말해, ASFV에는 K145R 유전자의 기능성 버전이 결여되어 있다. 적합하게, K145R 유전자는 서열식별번호 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338 또는 339의 서열을 포함한다. 적합하게, K145R 유전자는 서열식별번호 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338 또는 339와 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, K145R 유전자는 서열식별번호 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338 또는 339의 서열로 이루어진다.
본 발명의 ASFV의 한 실시양태에서, K145R 유전자는 부분적으로 또는 완전히 결실될 수 있다. 적합하게, 서열식별번호 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338 또는 339의 서열의 일부 또는 그들 모두는 ASFV 게놈으로부터 제거된다. 적합하게, ASFV 게놈에는 상기 서열 중 임의의 것이 결여되어 있다.
ASFV의 상이한 균주로부터의 K145R 단백질의 수탁 번호는 하기 표 4에 열거되어 있다.
<표 4>
상이한 ASFV 균주로부터의 K145R 단백질의 아미노산 서열이 하기 제시되어 있다.
한 실시양태에서, 본 발명의 ASFV는 K145R 단백질을 발현하지 않는다. 다시 말해, 본 발명의 ASFV는 서열식별번호 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351 또는 352의 서열을 갖는 단백질을 발현하지 않는다.
K145R은 숙주 소포체 (ER) 스트레스 반응을 억제한다 (Barber 2015 Stress modulators encoded by African swine fever virus; PhD thesis, St Georges, University of London, 2016). 이 반응은 언폴딩된 단백질의 축적으로 인해 발생하며, 상당량의 바이러스 단백질이 생성되기 때문에, 바이러스 감염 중에 활성화될 수 있다. ER 스트레스는 전사 인자 CCAAT-인핸서-결합 단백질 상동성 단백질 (CHOP)의 발현 증가 및 세포 핵에의 그의 축적을 유도한다. CHOP 활성은 궁극적으로 세포 아폽토시스를 초래하여 바이러스 복제를 제한한다.
K145R 기능은 CHOP에 대한 항체를 사용하는 면역형광 및 ER 스트레스 유도 후 세포 핵에의 그의 존재 평가, 및 루시페라제 유전자가 CHOP 프로모터의 제어하에 있는 루시페라제 리포터 검정법을 포함하는 방법에 의해 시험될 수 있다.
B125R
상이한 ASFV 균주로부터의 B125R 유전자의 유전자 (즉, 뉴클레오티드) 서열이 하기에 제시되어 있다:
한 실시양태에서, 본 발명의 ASFV는 B125R 유전자의 발현을 파괴시키는 DIVA 돌연변이를 포함한다. 다시 말해, ASFV에는 B125R 유전자의 기능성 버전이 결여되어 있다. 적합하게, B125R 유전자는 서열식별번호 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364 또는 365의 서열을 포함한다. 적합하게, B125R 유전자는 서열식별번호 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364 또는 365와 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, B125R 유전자는 서열식별번호 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364 또는 365의 서열로 이루어진다.
본 발명의 ASFV의 한 실시양태에서, B125R 유전자는 부분적으로 또는 완전히 결실될 수 있다. 적합하게, 서열식별번호 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364 또는 365의 서열의 일부 또는 그들 모두는 ASFV 게놈으로부터 제거된다. 적합하게, ASFV 게놈에는 상기 서열 중 임의의 것이 결여되어 있다.
ASFV의 상이한 균주로부터의 B125R 단백질의 수탁 번호는 하기 표 5에 열거되어 있다.
<표 5>
상이한 ASFV 균주로부터의 B125R 단백질의 아미노산 서열이 하기 제시되어 있다.
한 실시양태에서, 본 발명의 ASFV는 B125R 단백질을 발현하지 않는다. 다시 말해, 본 발명의 ASFV는 서열식별번호 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377 또는 378의 서열을 갖는 단백질을 발현하지 않는다.
B125R은 감염된 멧돼지 세포 (WSL-R)에서 발현되는 가장 풍부한 바이러스 단백질 중 하나인 것으로 확인되었다 (Kaβler et al. 2018 Sci. Rep. 8: 1471). 도 5에 제시된 바와 같이, B125R 발현은 세포 표면에서 검출될 수 있으며, 이는 B125R이 항체에 노출될 가능성이 있고, 강한 항체 반응을 유도할 가능성이 있다는 것을 시사하는 것이다.
다중유전자
패밀리
(
MGF
)
ASFV는 게놈의 좌측 및 우측 가변 영역에 존재하는 5개의 다중유전자 패밀리를 함유한다. MGF는 각 유전자에 존재하는 평균 코돈 개수를 따서 명명된다: MGF100, 110, 300, 360 및 505/530. MGF 300, 360 및 505/530 구성원의 N-말단 영역은 서로 상당한 유사성을 공유한다. MGF 360 및 505 패밀리는 감염된 세포 생존의 촉진 및 I형 인터페론 반응의 억제를 포함하는 숙주 범위 기능에 필수적인 유전자를 코딩한다.
본 발명에 따른 약독화된 ASFV는 하기 유전자:
다중유전자 패밀리 (MGF) 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L,
MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R, 및
MGF 505 1R, 2R 및 6R 중 하나 이상의 기능성 버전을 포함한다.
추가 측면에서, 본 발명은 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고; 하기 유전자:
다중유전자 패밀리 (MGF) 110 11L 및 12L,
MGF 360 6L, 10L, 11L, 12L, 13L, 및 14L, 및
MGF 505 1R 및 2R 중 하나 이상의 기능성 버전을 포함하는 것인, 약독화된 아프리카 돼지 열병 (ASF) 바이러스를 제공한다.
적합하게, 한 실시양태에서, 본 발명은 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고; 하기 유전자:
다중유전자 패밀리 (MGF) 110 5L, 6L, 8L, 및 12L, 및
MGF 360 6L, 10L, 11L, 12L, 13L, 14L 및 21R, 및
MGF 505 1R 및 2R 중 하나 이상의 기능성 버전을 포함하는 것인, ASFV를 제공한다.
적합하게, 한 실시양태에서, 본 발명은 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고; 하기 유전자:
다중유전자 패밀리 (MGF) 110 6L, 8L, 및 12L, 및
MGF 360 6L, 10L, 11L, 12L, 13L, 14L 및 21R, 및
MGF 505 1R 및 2R 중 하나 이상의 기능성 버전을 포함하는 것인, ASFV를 제공한다.
적합하게, 한 실시양태에서, 본 발명은 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고; 하기 유전자:
다중유전자 패밀리 (MGF) 110 12L, 및
MGF 360 6L, 10L, 11L, 12L, 13L, 14L, 및
MGF 505 1R 및 2R 중 하나 이상의 기능성 버전을 포함하는 것인, ASFV를 제공한다.
적합하게, 한 실시양태에서, 본 발명은 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고; 하기 유전자:
다중유전자 패밀리 (MGF) 360 6L, 10L, 11L, 12L, 13L, 및 14L, 및
MGF 505 1R 및 2R 중 하나 이상의 기능성 버전을 포함하는 것인, ASFV를 제공한다.
다양한 ASFV 균주의 게놈에서 상기 유전자 중 일부의 위치는 하기 표 6에 제시된다. 상응하는 Benin 97/1 유전자에 대한 각 유전자의 서열 동일성 또한 제시된다.
표 6a -
MGF
360-10L
표 6b - MGF 360-11L
표 6c - MGF 360-12L
표 6d - MGF 360-13L
표 6e -
MGF
360-14L
표 6f - MGF 505-1R
표 6g - MGF 505-2R
표 6h - MGF 505-3R
상이한 균주로부터의 상기 유전자의 유전자 (즉, 뉴클레오티드) 서열은 하기에 제시된다.
MGF 110 5L 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 110 5L의 기능성 버전을 포함한다. 적합하게, MGF 110 5L의 기능성 버전은 서열식별번호 266, 267, 268, 269, 270, 271, 272, 273, 274 또는 275의 서열을 포함한다. 적합하게, MGF 110 5L의 기능성 버전은 서열식별번호 266, 267, 268, 269, 270, 271, 272, 273, 274 또는 275와 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 110 5L의 기능성 버전은 서열식별번호 266, 267, 268, 269, 270, 271, 272, 273, 274 또는 275의 서열로 이루어진다.
MGF 110 6L 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 110 6L의 기능성 버전을 포함한다. 적합하게, MGF 110 6L의 기능성 버전은 서열식별번호 35, 36, 37, 38, 39, 40, 41, 42 또는 43의 서열을 포함한다. 적합하게, MGF 110 6L의 기능성 버전은 서열식별번호 35, 36, 37, 38, 39, 40, 41, 42 또는 43과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 110 6L의 기능성 버전은 서열식별번호 35, 36, 37, 38, 39, 40, 41, 42 또는 43의 서열로 이루어진다.
MGF
110 7L 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 110 7L의 기능성 버전을 포함한다. 적합하게, MGF 110 7L의 기능성 버전은 서열식별번호 247, 248, 249, 250, 251, 252, 253, 254, 255 또는 256의 서열을 포함한다. 적합하게, MGF 110 7L의 기능성 버전은 서열식별번호 247, 248, 249, 250, 251, 252, 253, 254, 255 또는 256과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 110 7L의 기능성 버전은 서열식별번호 247, 248, 249, 250, 251, 252, 253, 254, 255 또는 256의 서열로 이루어진다.
MGF 110 8L 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 110 8L의 기능성 버전을 포함한다. 적합하게, MGF 110 8L의 기능성 버전은 서열식별번호 44, 45, 46, 47, 48, 49 또는 50의 서열을 포함한다. 적합하게, MGF 110 8L의 기능성 버전은 서열식별번호 44, 45, 46, 47, 48, 49 또는 50과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 110 8L의 기능성 버전은 서열식별번호 44, 45, 46, 47, 48, 49 또는 50의 서열로 이루어진다.
MGF 110 12L 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 110 12L의 기능성 버전을 포함한다. 적합하게, MGF 110 8L의 기능성 버전은 서열식별번호 276, 277, 278, 279, 280, 281, 282, 283, 284, 285 또는 286의 서열을 포함한다. 적합하게, MGF 110 12L의 기능성 버전은 서열식별번호 276, 277, 278, 279, 280, 281, 282, 283, 284, 285 또는 286과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 110 12L의 기능성 버전은 서열식별번호 276, 277, 278, 279, 280, 281, 282, 283, 284, 285 또는 286의 서열로 이루어진다.
MGF 360 6L 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 360 6L의 기능성 버전을 포함한다. 적합하게, MGF 360 6L의 기능성 버전은 서열식별번호 51, 52, 53, 54, 55, 56, 57, 58, 59, 60 또는 61의 서열을 포함한다. 적합하게, MGF 360 6L의 기능성 버전은 서열식별번호 51, 52, 53, 54, 55, 56, 57, 58, 59, 60 또는 61과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 360 6L의 기능성 버전은 서열식별번호 51, 52, 53, 54, 55, 56, 57, 58, 59, 60 또는 61의 서열로 이루어진다.
MGF
360 10L 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 360 10L의 기능성 버전을 포함한다. 적합하게, MGF 360 10L의 기능성 버전은 서열식별번호 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73 또는 74의 서열을 포함한다. 적합하게, MGF 360 10L의 기능성 버전은 서열식별번호 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73 또는 74와 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 360 10L의 기능성 버전은 서열식별번호 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73 또는 74의 서열로 이루어진다.
MGF 360 11L 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 360 11L의 기능성 버전을 포함한다. 적합하게, MGF 360 11L의 기능성 버전은 서열식별번호 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86 또는 87의 서열을 포함한다. 적합하게, MGF 360 11L의 기능성 버전은 서열식별번호 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86 또는 87과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 360 11L의 기능성 버전은 서열식별번호 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86 또는 87의 서열로 이루어진다.
MGF 360 12L 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 360 12L의 기능성 버전을 포함한다. 적합하게, MGF 360 12L의 기능성 버전은 서열식별번호 88, 89, 90, 91, 92, 93, 94 95, 96, 97, 98 또는 99의 서열을 포함한다. 적합하게, MGF 360 12L의 기능성 버전은 서열식별번호 88, 89, 90, 91, 92, 93, 94 95, 96, 97, 98 또는 99와 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 360 12L의 기능성 버전은 서열식별번호 88, 89, 90, 91, 92, 93, 94 95, 96, 97, 98 또는 99의 서열로 이루어진다.
MGF
360 13L 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 360 13L의 기능성 버전을 포함한다. 적합하게, MGF 360 13L의 기능성 버전은 서열식별번호 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110 또는 111의 서열을 포함한다. 적합하게, MGF 360 13L의 기능성 버전은 서열식별번호 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110 또는 111과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 360 13L의 기능성 버전은 서열식별번호 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110 또는 111의 서열로 이루어진다.
MGF
360 14L 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 360 14L의 기능성 버전을 포함한다. 적합하게, MGF 360 14L의 기능성 버전은 서열식별번호 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 또는 123의 서열을 포함한다. 적합하게, MGF 360 14L의 기능성 버전은 서열식별번호 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 또는 123과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 360 14L의 기능성 버전은 서열식별번호 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 또는 123의 서열로 이루어진다.
MGF 360 21R 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 360 21R의 기능성 버전을 포함한다. 적합하게, MGF 360 21R의 기능성 버전은 서열식별번호 124, 125, 126, 127, 128, 129, 130, 131, 132 또는 133의 서열을 포함한다. 적합하게, MGF 360 21R의 기능성 버전은 서열식별번호 124, 125, 126, 127, 128, 129, 130, 131, 132 또는 133과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 360 21R의 기능성 버전은 서열식별번호 124, 125, 126, 127, 128, 129, 130, 131, 132 또는 133의 서열로 이루어진다.
MGF
505 1R 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 505 1R의 기능성 버전을 포함한다. 적합하게, MGF 505 1R의 기능성 버전은 서열식별번호 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145 또는 146의 서열을 포함한다. 적합하게, MGF 505 1R의 기능성 버전은 서열식별번호 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145 또는 146과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 505 1R의 기능성 버전은 서열식별번호 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145 또는 146의 서열로 이루어진다.
MGF
505 2R 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 505 2R의 기능성 버전을 포함한다. 적합하게, MGF 505 2R의 기능성 버전은 서열식별번호 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157 또는 158의 서열을 포함한다. 적합하게, MGF 505 2R의 기능성 버전은 서열식별번호 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157 또는 158과 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 505 2R의 기능성 버전은 서열식별번호 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157 또는 158의 서열로 이루어진다.
MGF 505 6R 유전자 서열
한 실시양태에서, 본 발명의 약독화된 ASFV는 MGF 505 6R의 기능성 버전을 포함한다. 적합하게, MGF 505 6R의 기능성 버전은 서열식별번호 257, 258, 259, 260, 261, 262, 263, 264 또는 265의 서열을 포함한다. 적합하게, MGF 505 2R의 기능성 버전은 서열식별번호 257, 258, 259, 260, 261, 262, 263, 264 또는 265와 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%의 동일성을 갖는 서열을 포함한다. 적합하게, MGF 505 6R의 기능성 버전은 서열식별번호 257, 258, 259, 260, 261, 262, 263, 264 또는 265의 서열로 이루어진다.
한 실시양태에서, 본 발명은 Benin 97/1 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 55 (MGF 360 6L), 서열식별번호 68 (MGF 360 10L), 서열식별번호 78 (MGF 360 11L), 서열식별번호 96 (MGF 360 12L), 서열식별번호 108 (MGF 360 13L) 및 서열식별번호 120 (MGF 360 14L), 및
서열식별번호 141 (MGF 505 1R) 및 서열식별번호 151 (MGF 505 2R).
한 실시양태에서, 본 발명은 China/2018/AnhuiXCGQ 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 52 (MGF 360 6L), 서열식별번호 63 (MGF 360 10L), 서열식별번호 76 (MGF 360 11L), 서열식별번호 89 (MGF 360 12L), 서열식별번호 101 (MGF 360 13L), 서열식별번호 113 (MGF 360 14L) 및 서열식별번호 125 (MGF 360 21R), 및
서열식별번호 135 (MGF 505 1R) 및 서열식별번호 148 (MGF 505 2R).
한 실시양태에서, 본 발명은 Georgia 2007/1 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 51 (MGF 360 6L), 서열식별번호 62 (MGF 360 10L), 서열식별번호 75 (MGF 360 11L), 서열식별번호 88 (MGF 360 12L), 서열식별번호 100 (MGF 360 13L), 서열식별번호 112 (MGF 360 14L) 및 서열식별번호 124 (MGF 360 21R), 및
서열식별번호 134 (MGF 505 1R) 및 서열식별번호 147 (MGF 505 2R).
한 실시양태에서, 본 발명은 Ken05/Tk1 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 35 (MGF 110 6L), 서열식별번호 44 (MGF 110 8L), 및
서열식별번호 58 (MGF 360 6L), 서열식별번호 65 (MGF 360 10L), 서열식별번호 86 (MGF 360 11L) 및 서열식별번호 130 (MGF 360 21R), 및
서열식별번호 145 (MGF 505 1R) 및 서열식별번호 156 (MGF 505 2R).
한 실시양태에서, 본 발명은 Ken06.Bus 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 36 (MGF 110 6L), 및
서열식별번호 61 (MGF 360 6L), 서열식별번호 64 (MGF 360 10L), 서열식별번호 87 (MGF 360 11L), 서열식별번호 99 (MGF 360 12L), 서열식별번호 111 (MGF 360 13L), 서열식별번호 123 (MGF 360 14L) 및 서열식별번호 132 (MGF 360 21R), 및
서열식별번호 144 (MGF 505 1R) 및 서열식별번호 158 (MGF 505 2R).
한 실시양태에서, 본 발명은 Kenya 1950 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 37 (MGF 110 6L), 서열식별번호 45 (MGF 110 8L), 및
서열식별번호 60 (MGF 360 6L), 서열식별번호 66 (MGF 360 10L), 서열식별번호 85 (MGF 360 11L), 서열식별번호 98 (MGF 360 12L), 서열식별번호 110 (MGF 360 13L), 서열식별번호 122 (MGF 360 14L) 및 서열식별번호 131 (MGF 360 21R), 및
서열식별번호 143 (MGF 505 1R) 및 서열식별번호 157 (MGF 505 2R).
한 실시양태에서, 본 발명은 L60 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 54 (MGF 360 6L), 서열식별번호 67 (MGF 360 10L), 서열식별번호 77 (MGF 360 11L), 서열식별번호 95 (MGF 360 12L), 서열식별번호 107 (MGF 360 13L) 및 서열식별번호 119 (MGF 360 14L), 및
서열식별번호 140 (MGF 505 1R) 및 서열식별번호 150 (MGF 505 2R).
한 실시양태에서, 본 발명은 Malawi Lil-20/1 (1983) 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 38 (MGF 110 6L), 서열식별번호 46 (MGF 110 8L), 및
서열식별번호 59 (MGF 360 6L), 서열식별번호 74 (MGF 360 10L), 서열식별번호 84 (MGF 360 11L), 서열식별번호 97 (MGF 360 12L), 서열식별번호 109 (MGF 360 13L), 서열식별번호 121 (MGF 360 14L) 및 서열식별번호 133 (MGF 360 21R), 및
서열식별번호 146 (MGF 505 1R) 및 서열식별번호 155 (MGF 505 2R).
한 실시양태에서, 본 발명은 Mkuzi 1979 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 39 (MGF 110 6L), 서열식별번호 47 (MGF 110 8L), 및
서열식별번호 57 (MGF 360 6L), 서열식별번호 69 (MGF 360 10L), 서열식별번호 79 (MGF 360 11L), 서열식별번호 94 (MGF 360 12L), 서열식별번호 106 (MGF 360 13L), 서열식별번호 118 (MGF 360 14L) 및 서열식별번호 128 (MGF 360 21R), 및
서열식별번호 138 (MGF 505 1R) 및 서열식별번호 149 (MGF 505 2R).
한 실시양태에서, 본 발명은 Pretorisuskop/96/4 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 40 (MGF 110 6L), 서열식별번호 48 (MGF 110 8L), 및
서열식별번호 56 (MGF 360 6L), 서열식별번호 70 (MGF 360 10L), 서열식별번호 81 (MGF 360 11L), 서열식별번호 93 (MGF 360 12L), 서열식별번호 105 (MGF 360 13L), 서열식별번호 117 (MGF 360 14L) 및 서열식별번호 127 (MGF 360 21R), 및
서열식별번호 142 (MGF 505 1R) 및 서열식별번호 153 (MGF 505 2R).
한 실시양태에서, 본 발명은 Tengani 62 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 41 (MGF 110 6L), 및
서열식별번호 71 (MGF 360 10L), 서열식별번호 82 (MGF 360 11L), 서열식별번호 90 (MGF 360 12L), 서열식별번호 102 (MGF 360 13L), 서열식별번호 114 (MGF 360 14L) 및 서열식별번호 126 (MGF 360 21R), 및
서열식별번호 136 (MGF 505 1R) 및 서열식별번호 152 (MGF 505 2R).
한 실시양태에서, 본 발명은 Warmbaths 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 42 (MGF 110 6L), 서열식별번호 49 (MGF 110 8L), 및
서열식별번호 53 (MGF 360 6L), 서열식별번호 73 (MGF 360 10L), 서열식별번호 80 (MGF 360 11L), 서열식별번호 92 (MGF 360 12L), 서열식별번호 104 (MGF 360 13L), 서열식별번호 116 (MGF 360 14L) 및 서열식별번호 129 (MGF 360 21R), 및
서열식별번호 137 (MGF 505 1R) 및 서열식별번호 154 (MGF 505 2R).
한 실시양태에서, 본 발명은 Warthog 균주로부터의 하기 서열 중 하나 이상, 예컨대, 그들 모두를 포함하는 ASFV를 제공한다:
서열식별번호 43 (MGF 110 6L), 서열식별번호 50 (MGF 110 8L), 및
서열식별번호 72 (MGF 360 10L), 서열식별번호 83 (MGF 360 11L), 서열식별번호 91 (MGF 360 12L), 서열식별번호 103 (MGF 360 13L), 서열식별번호 115 (MGF 360 14L), 및
서열식별번호 139 (MGF 505 1R).
상기 유전자의 번역 생성물 (즉, 단백질 서열)을 하기에 제시된다:
Benin 97/1
MGF
유전자 단백질 서열
MGF 110 5L 단백질 서열
MGF 110 12L 단백질 서열
MGF 360 12L 단백질 서열
MGF 360 13L 단백질 서열
MGF
360 14L 단백질 서열
MGF 505 1R 단백질 서열
DP148R
DP148R 유전자는 Benin 97/1 게놈 상의 위치 177915 내지 178679에, ASFV 게놈의 우측 단부 근부에 위치한다. DP148R 유전자는 또한 MGF 360 18R로도 지칭될 수 있다. DP148R은 감염 후 초기에 발현된다. DP148R 단백질의 아미노산 서열은 다른 단백질과 유의적인 유사성이 없고; 2차 구조는 주로 나선형인 것으로 예측되지만, 신호 펩티드 또는 막횡단 도메인은 분명하지 않다.
DP148R은 I형 인터페론을 억제한다. DP148R은 또한 NF-κB 전사 인자의 활성화를 억제한다 (도 7 참조). DP148R은 NF-κB의 p65 서브유닛의 핵 전위를 억제한다 (도 8 참조). NF-κB는 바이러스 감염에 대한 숙주의 선천 면역계 반응의 일부로서 인터페론 및 염증유발성 시토카인의 발현을 제어한다. DP148R에 의한 NF-κB의 억제는 ASFV에 감염된 세포에 의해 생성되는 I형 인터페론(IFN) 및 염증유발성 시토카인 및 케모카인의 양을 감소시키고, ASFV가 숙주의 선천성 면역 반응을 우회하도록 하여 바이러스 복제를 촉진하고, 적응 반응의 발생을 파괴시킨다.
상이한 ASFV 균주로부터의 DP148R 유전자의 게놈내 유전자 (즉, 뉴클레오티드) 서열 및 위치가 하기에 제시되어 있다.
상이한 ASFV 균주로부터의 DP148R 단백질의 아미노산 서열은 하기에 서열식별번호 11 내지 19 및 301 내지 305로서 제시되어 있다:
혈구흡착
혈구흡착은 ASFV에 감염된 세포가 그의 표면 상에 적혈구(erythrocyte) (적혈구(red blood cell))를 흡착하는 현상이다. ASFV에 의해 유도된 혈구흡착 정도는 예컨대, 본원에 기재된 바와 같은 혈구흡착 (HAD) 검정법을 사용하여 측정될 수 있다 (예를 들어, 실시예 1 및 3 참조). 예를 들어, 세포 (예컨대, Vero 세포 또는 돼지 골수 세포)를 단백질로 형질감염시키거나, 또는 ASFV에 감염시킨 후, 이어서, 적혈구를 첨가하고, 이미징에 의해 혈구흡착 정도를 검출할 수 있다. 이러한 방식으로, 상이한 단백질 및 바이러스를 그가 혈구흡착에 미치는 영향을 시험할 수 있다.
EP402R 및 EP153R은 ASFV 감염된 세포의 혈구흡착을 매개하는 데 관여한다.
한 실시양태에서, 본 발명은 혈구흡착을 유도하는 ASF 바이러스의 능력이 EP153R 및 EP402R 유전자의 발현 및/또는 활성이 파괴되지 않은 상응하는 ASF 바이러스와 비교하여 감소된 약독화된 ASF 바이러스를 제공한다. 한 실시양태에서, 본 발명은 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고;
하기 유전자:
다중유전자 패밀리 (MGF) 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L,
MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R, 및
MGF 505 1R, 2R 및 6R 중 하나 이상의 기능성 버전을 포함하고;
혈구흡착을 유도하는 아프리카 돼지 열병 (ASF) 바이러스의 능력이 EP153R 유전자 및/또는 EP402R 유전자의 발현 및/또는 활성이 파괴되지 않은 상응하는 ASF 바이러스와 비교하여 감소된 약독화된 ASF 바이러스를 제공한다.
본 발명은 또한 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고;
하기 유전자:
다중유전자 패밀리 (MGF) 110 11L 및 12L,
MGF 360 6L, 10L, 11L, 12L, 13L, 및 14L, 및
MGF 505 1R 및 2R 중 하나 이상의 기능성 버전을 포함하고;
혈구흡착을 유도하는 ASF 바이러스의 능력이 EP153R 유전자 및/또는 EP402R 유전자의 발현 및/또는 활성이 파괴되지 않은 상응하는 ASF 바이러스와 비교하여 감소된 약독화된 ASF 바이러스를 제공한다.
본 발명은 또한 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고;
하기 유전자:
다중유전자 패밀리 (MGF) 110 5L, 6L, 8L 및 12L,
MGF 360 6L, 10L, 11L, 12L, 13L, 14L 및 21R, 및
MGF 505 1R 및 2R 중 하나 이상의 기능성 버전을 포함하고;
혈구흡착을 유도하는 ASF 바이러스의 능력이 EP153R 유전자 및/또는 EP402R 유전자의 발현 및/또는 활성이 파괴되지 않은 상응하는 ASF 바이러스와 비교하여 감소된 약독화된 ASF 바이러스를 제공한다.
또 다른 측면에서, 본 발명은 본 발명의 EP402R 단백질 및/또는 본 발명의 폴리뉴클레오티드를 포함하는 ASF 바이러스로서, 혈구흡착을 유도하는 ASF 바이러스의 능력이 본 발명의 EP402R 단백질 및/또는 본 발명의 폴리뉴클레오티드를 포함하지 않는 상응하는 ASF 바이러스와 비교하여 감소된 것인, ASF 바이러스를 제공한다.
본 발명의 약독화된 ASF 바이러스의 한 실시양태에서, EP153R 유전자 및/또는 EP402R 유전자의 혈구흡착을 매개하는 능력은 파괴될 수 있다. 한 실시양태에서, EP153R 유전자의 혈구흡착을 매개하는 능력은 파괴될 수 있다. 한 실시양태에서, EP402R 유전자의 혈구흡착을 매개하는 능력은 파괴될 수 있다.
혈구흡착을 감소시키거나, 또는 혈구흡착을 매개하는 능력을 파괴시킨다는 것은 본 발명의 ASFV로 감염된 세포가, 야생형 ASFV로, 또는 EP153R 및 EP402R 유전자의 발현 및/또는 활성이 파괴되지 않았거나, 또는 본 발명의 EP402R 단백질 및/또는 본 발명의 폴리뉴클레오티드를 포함하지 않는, 본 발명의 ASFV에 상응하거나, 또는 본질적으로 그에 상응하는 ASF 바이러스로 감염된 세포보다 그의 표면에 더 적은 적혈구를 흡착한다는 것을 의미한다. 혈구흡착을 감소시키거나, 또는 혈구흡착을 매개하는 능력을 파괴시킨다는 것은 또한 돌연변이체, 비기능성 EP153R 또는 EP402R 단백질을 발현하도록 형질감염된 세포가 야생형 EP153R 또는 EP402R 단백질로 형질감염된 세포보다 그의 표면에 더 적은 적혈구를 흡착한다는 것을 의미한다. 감염된/형질감염된 세포의 표면에 흡착된 적혈구의 개수는 적어도 50, 60, 70, 80 또는 90%만큼 감소될 수 있다. 한 실시양태에서, 혈구흡착은 폐기되고, 즉, 본 발명의 약독화된 ASFV로 감염되거나, 또는 돌연변이체, 비기능성 EP153R 또는 EP402R 단백질로 형질감염된 세포의 표면에 어떤 적혈구도 흡착되지 않는다.
유전자 발현 및 활성
한 실시양태에서, 본 발명의 ASF 바이러스는 유전자 EP153R 및 EP402R의 파괴된 발현 및/또는 활성을 갖는다. 또 다른 실시양태에서, 본 발명의 ASF 바이러스는 유전자 EP153R, EP402R 및 K145R의 파괴된 발현 및/또는 활성을 갖는다. 이들 유전자는 본원에서 "파괴된 유전자"로서 지칭될 수 있다.
한 실시양태에서, 본 발명은 유전자 EP153R 및 EP402R의 발현이 파괴된 ASFV를 제공한다. 한 실시양태에서, 본 발명은 유전자 EP153R, EP402R 및 K145R의 발현이 파괴된 ASFV를 제공한다. 적합하게, EP153R 유전자의 발현이 파괴된 것이다. 적합하게, EP402R 유전자의 발현이 파괴된 것이다. 적합하게, K145R 유전자의 발현이 파괴된 것이다. 한 실시양태에서, 본 발명은 유전자 EP153R 및 EP402R의 활성이 파괴된 ASFV를 제공한다.
유전자와 관련하여 "발현"이라는 용어는 유전자, 예컨대, RNA의 생성물 및/또는 단백질을 생산할 수 있는 ASF 바이러스의 능력을 지칭한다. 유전자 발현 파괴는 유전자 생성물 생산 감소를 의미한다. 유전자 발현은 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 적어도 90% 및/또는 적어도 95%만큼 감소될 수 있다. 유전자 발현은 유전자 생성물, 예컨대, RNA 및/또는 단백질 생산이 완전히 폐기되는 (즉, 유전자 생성물이 전혀 생산되지 않는) 정도로 감소될 수 있다. 유전자 발현의 파괴는 파괴되지 않은 유전자 발현에 비해 유전자 발현을 감소시킨다. 예를 들어, 돌연변이된 유전자는 야생형 버전의 유전자와 비교하여 감소된 발현을 가질 수 있다.
발현이 파괴된 유전자는 완전히 전사 및 번역되지 않을 수 있다. 유전자 전사는 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 적어도 90% 및/또는 적어도 95%만큼 감소될 수 있다. 유전자 전사는 폐기될 수 있다 (즉, 유전자는 전사되지 않을 수 있다). 유전자 번역은 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 적어도 90% 및/또는 적어도 95%만큼 감소될 수 있다. 유전자 번역은 폐기될 수 있다. 유전자는 전사되지만, 번역되지 않을 수 있다. 유전자는 전사 및 번역되지만, 단백질이 너무 빠르게 분해되어 그의 기능을 수행하지 못할 수 있다. 유전자는 전사 및 번역되지만, 단백질은 비기능성일 수 있다.
유전자 발현은 관련 기술분야에 공지된 기술에 의해 측정될 수 있다. 예를 들어, 유전자로부터 전사된 mRNA의 양은 예컨대, 정량적 중합효소 연쇄 반응 (qPCR)을 사용하여 정량화될 수 있다. 대안적으로 또는 추가로, 단백질의 양은 예컨대, 웨스턴 블롯팅 또는 질량 분석법을 사용하여 정량화될 수 있다.
유전자와 관련하여 "활성"이라는 용어는 유전자 그의 기능을 수행할 수 있는 유전자의 능력을 지칭한다. 상이한 유전자는 상이한 활성, 즉, 그들이 수행하는 상이한 기능을 가지고 있다. 주어진 유전자는 다중 활성을 가질 수 있고; 유전자 활성의 파괴는 이러한 활성 중 하나 이상의 파괴를 의미한다. 하나 이상의 다른 활성은 파괴되지 않은 채로, 유전자의 하나 이상의 활성이 파괴될 수 있다. 유전자 활성의 파괴는 파괴되지 않은 경우 유전자의 활성에 비해 유전자의 활성을 감소시킨다. 예를 들어, 돌연변이된 유전자는 야생형 버전의 유전자와 비교하여 감소된 활성을 가질 수 있다. 유전자 활성이 완전히 폐기될 정도로 유전자 활성이 감소될 수 있다.
본 발명에 따른 ASFV는 비-기능성 버전의 파괴된 유전자를 포함할 수 있다.
감소된 양의 유전자 생성물이 유전자가 하나 이상의 그의 활성을 효과적으로 수행할 수 없다는 것을 의미하는 바, 유전자 발현의 파괴 또한 상기 유전자의 활성을 파괴시킬 수 있다.
한 실시양태에서, 본 발명의 약독화된 ASF 바이러스는 유전자 EP153R 및 EP402R의 발현 및/또는 활성을 파괴시키는 돌연변이를 포함한다.
유전자 발현 및/또는 활성은 mRNA로의 유전자 전사를 파괴시킴으로써, 즉, 유전자 전사를 완전히 폐기하는 것과 같이 유전자 전사를 감소시킴으로써 파괴될 수 있다. 유전자 발현 및/또는 활성은 mRNA의 단백질로의 번역을 파괴시킴으로써 파괴될 수 있다. 한 실시양태에서, 약독화된 ASF 바이러스는 유전자의 전사 및/또는 번역을 감소시키는 돌연변이를 포함한다. 한 실시양태에서, 약독화된 ASF 바이러스는 유전자가 전사 및/또는 번역되지 않도록 하는 (즉, 전사 및/또는 번역이 완전한 폐기되도록 하는) 돌연변이를 포함한다.
유전자 발현 및/또는 활성은 유전자와 연관된 비-코딩 서열, 예컨대, 프로모터를 돌연변이시킴으로써 파괴될 수 있다. 한 실시양태에서, 약독화된 ASF 바이러스는 파괴된 유전자 중 하나 이상의 프로모터에 돌연변이를 포함한다.
유전자 발현 및/또는 활성은 파괴된 유전자 중 하나 이상의 코딩 서열을 돌연변이시킴으로써 파괴될 수 있다.
유전자의 기능성 버전
본 발명의 약독화된 ASFV는 하기 유전자:
다중유전자 패밀리 (MGF) 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L,
MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R, 및
MGF 505 1R, 2R 및 6R 중 하나 이상의 기능성 버전을 포함한다.
일부 실시양태에서, 본 발명의 약독화된 ASFV는 하기 유전자: MGF 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L; MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R; 및 MGF 505 1R, 2R 및 6R 중 하나 이상의 기능성 버전을 포함할 수 있다. 적합하게, 약독화된 ASFV는 하기 유전자: MGF 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L; MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R; 및 MGF 505 1R, 2R 및 6R 중 2개 이상, 예컨대, 3개 이상, 4개 이상, 5개 이상, 6개 이상, 7개 이상, 8개 이상, 9개 이상, 10개 이상, 11개 이상, 12개 이상, 13개 이상, 14개 이상, 15개 이상, 16개 이상, 17개 이상, 18개 이상, 19개 이상, 20개 이상, 21개, 또는 22개의 것의 기능성 버전을 포함한다. 한 실시양태에서, 약독화된 ASFV는 하기 유전자: MGF 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L; MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R; 및 MGF 505 1R, 2R 및 6R 모두의 기능성 버전을 포함한다. 적합하게, 본 발명의 약독화된 ASF 바이러스는 EP153R 및 EP402R 이외의 다른 모든 ASF 바이러스 유전자의 기능성 버전을 포함한다. 적합하게, 본 발명의 약독화된 ASF 바이러스는 EP153R, EP402R 및 K145R 이외의 다른 모든 ASF 바이러스 유전자의 기능성 버전을 포함한다.
유전자의 "기능성 버전"이라는 표현은 유전자의 발현 및 활성이 파괴되지 않는 유전자를 의미한다. 유전자의 기능성 버전은 유전자 발현 또는 유전자 활성을 파괴시키는 방식으로 돌연변이될 수 없다. 유전자의 기능성 버전은 돌연변이를 포함하지 않을 수 있다. 유전자의 기능성 버전의 코딩 서열은 완전하고, 비중단된 것일 수 있다. 유전자의 기능성 버전은 완전히 전사되고, 번역될 수 있다. 유전자의 기능성 버전은 완전 코딩 서열을 포함할 수 있다.
유전자의 기능성 버전은 야생형 ASFV 분리주 중의 유전자에 상응할 수 있다. 유전자의 기능성 버전은 병독성 ASFV 균주 중의 유전자에 상응할 수 있다. 유전자의 기능성 버전의 서열은 야생형 ASFV 분리주 또는 병독성 ASFV 균주 중의 유전자 서열과 동일할 수 있다. 유전자의 기능성 버전의 서열은 본 발명의 약독화된 ASFV의 유래 기점이 되는 야생형 ASFV 분리주 중의 유전자 서열과 동일할 수 있다. 유전자의 기능성 버전은 야생형 ASFV 분리주 중의 유전자의 천연 변이체일 수 있다.
유전자의 기능성 버전은 돌연변이를 포함할 수 있다. 그러나, 돌연변이는 유전자의 발현 또는 활성을 파괴하지 않아야 한다. 다시 말해, 돌연변이는 유전자의 기능에 영향을 미치지 않아야 한다. 유전자의 기능성 버전은 하나 이상의 동의 돌연변이 (즉, 유전자가 코딩하는 단백질의 아미노산 서열을 변경시키지 않는 돌연변이)를 포함할 수 있다. 유전자의 기능성 버전은 동의 또는 비동의일 수 있는 하나 이상의 침묵 돌연변이를 포함할 수 있다. 유전자의 기능성 버전은 유전자의 발현 또는 활성을 파괴시키지 않는 결실을 포함할 수 있다. 유전자의 기능성 버전은 유전자의 발현 또는 활성을 파괴시키지 않는 하나 이상의 단일 뉴클레오티드 다형성 (SNP)을 포함할 수 있다.
돌연변이
유전자 발현 및/또는 활성은 ASFV 게놈을 돌연변이시킴으로써, 즉, ASFV 게놈의 뉴클레오티드 서열을 돌연변이시킴으로써 파괴된다. "돌연변이"는 공지된 ASFV 유전자형 대비 ASFV 게놈의 뉴클레오티드 서열의 변이를 의미한다. 돌연변이는 하나 이상의 뉴클레오티드를 상이한 뉴클레오티드로 변이 (즉, 치환), 뉴클레오티드 부가 (즉, 삽입), 뉴클레오티드 제거 (즉, 결실) 및/또는 이의 조합을 포함한다. 한 실시양태에서, 본 발명의 ASF 바이러스는 유전자 EP153R 및 EP402R의 발현 및/또는 활성을 파괴시키는 하나 이상의 돌연변이를 포함한다. 한 실시양태에서, 본 발명의 ASF 바이러스는 K145R 유전자의 발현을 파괴시키는 하나 이상의 돌연변이를 포함한다.
유전자 발현 및/또는 활성을 파괴시키는 돌연변이는 ASFV 게놈의 비-코딩 서열에서 및/또는 ASFV 게놈의 코딩 서열에서 이루어질 수 있다. 본 발명의 약독화된 ASF 바이러스는 EP153R 유전자의 발현 및/또는 활성을 파괴시키는 하나 이상의 돌연변이를 비-코딩 영역에 및/또는 EP402R 유전자의 발현 및/또는 활성을 파괴시키는 하나 이상의 돌연변이를 비-코딩 영역에 포함할 수 있다. 본 발명의 ASF 바이러스는 K145R 유전자의 발현 및/또는 활성을 파괴시키는 하나 이상의 돌연변이를 비-코딩 영역에 포함할 수 있다.
본 발명의 ASF 바이러스는 EP153R 유전자의 발현 및/또는 활성을 파괴시키는 하나 이상의 돌연변이를 EP153R 유전자의 코딩 영역에 및/또는 EP402R 유전자의 발현 및/또는 활성을 파괴시키는 하나 이상의 돌연변이를 EP402R 유전자의 코딩 영역에 포함할 수 있다. 본 발명의 약독화된 ASF 바이러스는 K145R 유전자의 발현을 파괴시키는 하나 이상의 돌연변이를 K145R 유전자의 코딩 영역에 포함할 수 있다.
결실
본 발명의 ASFV에서, 유전자의 발현 및/또는 활성은 결실에 의해 파괴될 수 있다. 다시 말해, 유전자의 발현 및/또는 활성은 결실인 돌연변이에 의해 파괴될 수 있다. 본 발명의 ASFV는 결실에 의해 유전자의 기능성 버전이 결여되도록 만들 수 있다. 다시 말해, ASFV에 유전자의 기능성 버전이 결여되게 하는 돌연변이는 결실일 수 있다.
"결실"은 ASFV 게놈 뉴클레오티드 서열의 일부의 제거를 의미한다. 결실은 연속적일 수 있거나, 또는 복수의 서열 섹션의 결실을 포함할 수 있다. 결실은 본원에 기재된 임의의 방식으로 유전자 발현 및/또는 활성을 파괴할 수 있다. 결실은 본원에 기재된 임의의 방식으로 ASFV에 유전자의 기능성 버전이 결여되게 할 수 있다.
결실은 생성되는 유전자 생성물을 변경시킬 수 있다. 결실은 유전자가 전사 및/또는 번역되지 않도록 할 수 있다. 결실은 유전자의 mRNA로의 전사를 파괴할 수 있다. 예를 들어, 유전자의 프로모터의 결실이 전사를 파괴할 수 있다. 결실은 mRNA의 단백질로의 번역을 파괴할 수 있다. 예를 들어, 시작 코돈의 결실이 번역을 파괴할 수 있다. 유전자 발현 및/또는 활성은 예컨대, 프로모터와 같은 유전자와 연관된 비-코딩 서열을 결실시킴으로써 파괴될 수 있다.
유전자 발현 및/또는 활성은 유전자의 코딩 서열을 결실시킴으로써 파괴될 수 있다. 유전자의 코딩 서열을 결실시킴으로써 ASFV에 유전자의 기능성 버전이 결여되게 할 수 있다. "유전자의 결실" (예컨대, "부분적으로 결실된" 또는 "완전히 결실된")이라는 표현은 유전자의 발현 및/또는 활성이 파괴되도록 하는 충분한 양의 코딩 서열의 결실을 지칭한다.
코딩 서열의 결실은 부분적일 수 있다 (즉, 코딩 서열의 일부가 결실된다). 결실은 예를 들어, 유전자의 코딩 서열의 적어도 50, 60, 70, 80 또는 90%를 제거할 수 있다. 유전자 발현 및/또는 활성을 파괴시키기 위해 결실되어야 하는 코딩 서열의 양은 극소량일 수 있다. 예를 들어, 유전자의 부분적 결실은, 단 시작 코돈 (ATG)의 결실만으로도 유전자의 발현 및/또는 활성을 파괴시키는 데 충분하다면, 이를 의미할 수 있다. 다른 극단에서, 결실은 완전한 것일 수 있으며, 이 경우, 유전자의 코딩 서열의 100%가 결실된다 (즉, 야생형 분리주의 상응하는 게놈과 비교할 때, 코딩 서열 모두 부재). 다시 말해, "완전히 결실된"은 해당 유전자의 코딩 서열 모두가 결실된 것을 의미한다.
유전자의 부분적 및 완전한 결실은 관련 기술분야에 공지된 기술, 예컨대, Cre-LoxP 및 Flp-FRT 시스템을 통한 조건부 표적화를 사용하여, 또는 조작된 뉴클레아제, 예컨대, 메가뉴클레아제, 아연 핑거 뉴클레아제 (ZFN), 전사 활성인자 유사 이펙터 뉴클레아제 (TALEN) 및 CRISPR-Cas 시스템의 Cas를 이용하여 이중 가닥 파단 (DSB) 및 수복을 유도함으로써 이루어질 수 있다. DSB 수복은 DSB의 어느 한쪽에 플랭킹하는 서열과 상동성인 서열 내에 원하는 돌연변이된 뉴클레오티드 서열을 포함하는 벡터를 제공함으로써 원하는 돌연변이를 도입하기 위해 이용될 수 있다. 그 결과 원하는 돌연변이가 DSB 부위에 삽입된다. 상기와 같은 뉴클레아제는 게놈 내의 특정 부위에서 DSB를 유도하도록 조작될 수 있다. 예를 들어, 키메라 메가뉴클레아제는 관심 유전자 또는 게놈 영역 내의 표적 인식 서열을 인식하기 위해 공지된 단백질 유닛을 조합함으로써 쉽게 생성될 수 있다. ZFN은 또한 예를 들어, DNA의 특정 영역에 결합하기 위해 특이성이 공지된 아연 핑거 유닛을 조합하여 특정 서열을 표적화하도록 디자인될 수 있다. TALEN은 뉴클레아제 도메인을 DNA 결합 TALE (전사 활성인자 유사 이펙터) 도메인에 융합하여 디자인된 인공 제한 효소이다. TALE 도메인은 단일 뉴클레오티드를 인식하는 아미노산 반복부로 이루어진 탠덤 어레이이며, 이는 DNA의 특정 영역을 표적화하도록 디자인될 수 있다. CRISPR-Cas 시스템은 Cas (CRISPR-연관 단백질) 뉴클레아제, 및 CRISPR 서열에 상보적인 DNA의 특정 가닥을 인식하고 절단하도록 Cas 단백질을 가이드하는 CRISPR (일정한 간격을 두고 주기적으로 분포하는 짧은 회문 반복부) RNA 서열로 이루어진다. 따라서, 단일 가닥 가이드 RNA (sgRNA)는 DNA의 특정 영역에 결합하고, Cas가 DSB를 도입하게 가이드하도록 디자인될 수 있다. 따라서, 유전자의 뉴클레오티드 (예컨대, DNA 또는 cDNA) 서열이 공지되어 있다면, 공지된 뉴클레아제 시스템을 이용하여 유전자에 부분적 또는 전체 결실을 도입할 수 있다.
코딩 서열의 결실은 연속적일 수 있거나, 또는 복수의 코딩 서열 섹션의 결실을 포함할 수 있다. 결실은 결실이 유전자의 발현 및/또는 활성을 파괴하도록, 즉, 기능성 유전자 생성물, 예컨대, 단백질이 유전자로부터 더 이상 생성되지 않도록 충분한 양의 코딩 서열을 제거하여야 한다.
중단
유전자의 발현 및/또는 활성은 유전자의 중단에 의해 파괴될 수 있다. 다시 말해, 유전자의 발현 및/또는 활성을 파괴하는 돌연변이는 유전자를 중단시키는 것일 수 있다.
본 발명의 ASFV의 한 실시양태에서, 유전자 EP153R, EP402R 및 K145R은 각각 중단될 수 있다. EP153R 유전자는 중단될 수 있다. EP402R 유전자는 중단될 수 있다. K145R 유전자는 중단될 수 있다.
"중단"은 돌연변이가 기능성 유전자 생성물, 예컨대, 단백질이 더 이상 생성되지 않도록 유전자의 코딩 서열을 변경하는 것을 의미한다. 용어 "중단"은 유전자를 중단시키는 돌연변이를 지칭하기 위해 본원에서 사용될 수 있다. 돌연변이(들)는 유전자의 발현 및/또는 활성이 파괴되는, 즉, 유전자로부터 기능성 유전자 생성물, 예컨대, 단백질이 더 이상 생성되지 않도록 하는 방식으로 코딩 서열을 중단시켜야 한다.
중단은 유전자의 코딩 서열 내의 결실 (즉, 하나 이상의 뉴클레오티드의 제거) 뿐만 아니라, 유전자의 코딩 서열 내의 치환 (즉, 하나 이상의 뉴클레오티드의 상이한 뉴클레오티드로의 대체) 및 삽입 (즉, 하나 이상의 뉴클레오티드의 부가)을 포함할 수 있다.
중단은 유전자 생성물 생성을 완전히 폐기할 수 있다. 예를 들어, 유전자 생성물이 단백질인 경우, 중단은 mRNA를 넌센스로 만들어 mRNA가 분해되고, 단백질이 번역되지 않도록 하여 단백질 생성을 폐기시킬 수 있다. 중단은 생성되는 유전자 생성물을 변경할 수 있다. 중단으로 유전자는 전사 및/또는 번역되지 않을 수 있다.
중단은 점 돌연변이 (즉, 단일 뉴클레오티드의 치환, 삽입 또는 결실)일 수 있다. 중단은 하나 이상의 뉴클레오티드의 삽입일 수 있다. 중단은 결실일 수 있다. 유전자는 유전자의 중단을 초래하는 다중 돌연변이를 포함할 수 있다.
중단은 뉴클레오티드의 삽입 또는 결실에 의해 유발되는 프레임 시프트 돌연변이일 수 있다. 프레임 시프트에 기인하여 프레임 시프트 하류의 코돈은 상이한 아미노산으로 판독된다. 생성되는 단백질은 비-기능성일 수 있다.
중단은 시작 코돈의 돌연변이일 수 있다. 시작 코돈은 전형적으로 ATG이다. 시작 코돈의 돌연변이 (예컨대, 뉴클레오티드 중 1개, 2개 또는 3개의 점 돌연변이)는 번역이 해당 코돈에서 시작되지 않다는 것을 의미한다. 번역은 더 하류에 있는 후속 시작 코돈에서 시작될 수 있다. 후속 시작 코돈이 프레임 내에 있는 경우, N-말단이 말단절단된 단백질 버전이 생성되어 비-기능성일 수 있다. 후속 시작 코돈이 프레임 내에 있지 않다면, 완전히 상이하거나, 또는 넌센스 단백질이 생성되고, 이는 비-기능성일 수 있다. 후속 시작 코돈이 않다면, 번역이 완전히 폐기되고, 단백질은 생성되지 않는다.
중단은 정지 코돈 (TAG, TAA 또는 TGA)의 돌연변이일 수 있다. 정지 코돈의 돌연변이 (논스톱 돌연변이로도 지칭)에 기인하여 mRNA는 번역되지 않아야 하는 서열로 계속 번역된다. 생성된 단백질은 그의 과도한 길이로 인해 비-기능성일 수 있다.
아미노산 변이
본 발명의 ASF 바이러스의 실시양태에서, EP402R 유전자는 EP402R 단백질의 리간드 결합 도메인 중의 하나 이상의 아미노산을 변이시키는 하나 이상의 돌연변이를 포함할 수 있다. EP402R의 아미노산 변이는 본원 다른 곳에 상세히 설명되어 있다.
ASF
바이러스에서의 돌연변이 조합
본원에 기재된 유전자 발현 및/또는 활성을 파괴시키는 돌연변이는 본 발명의 ASFV에서 조합될 수 있다. 즉, 본 발명의 ASFV에서 EP153R 및 EP402R 유전자는 각각 다른 유전자 중 임의의 것과 동일한 유형의 돌연변이에 의해, 또는 다른 유전자 중 임의의 것과 상이한 유형의 돌연변이에 의해 파괴될 수 있다. 추가로, K145R 유전자는 다른 유전자 중 임의의 것과 동일한 유형의 돌연변이에 의해, 또는 다른 유전자 중 임의의 것과 상이한 유형의 돌연변이에 의해 파괴될 수 있다.
예를 들어, 본 발명의 ASFV에서, EP153R은 완전한 결실에 의해 파괴될 수 있고, EP402R은 그의 리간드 결합 도메인 중의 아미노산 변이에 의해 파괴될 수 있고, K145R은 프로모터 서열의 돌연변이에 의해 파괴될 수 있다. 대안적인 예로서, EP153R은 중단에 의해 파괴될 수 있고, EP402R은 완전한 결실에 의해 파괴될 수 있고, K145R은 부분적 결실에 의해 파괴될 수 있다.
한 실시양태에서, 본 발명은
EP153R 유전자가 완전히 결실되고,
EP402R 유전자가, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96에 상응하는 EP402R 단백질 중의 위치의 아미노산을 R로 변이시키는 돌연변이를 포함하는 것인 ASFV를 제공한다.
한 실시양태에서, 본 발명은
EP153R 유전자 및 K145R 유전자가 각각 완전히 결실되고,
EP402R 유전자가, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96에 상응하는 EP402R 단백질 중의 위치의 아미노산을 R로 변이시키는 돌연변이를 포함하는 것인 ASFV를 제공한다.
한 실시양태에서, 본 발명은
EP153R 유전자가 완전히 결실되고,
EP402R 유전자가, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 W99에 상응하는 EP402R 단백질 중의 위치의 아미노산을 D로 변이시키는 돌연변이를 포함하는 것인 ASFV를 제공한다.
한 실시양태에서, 본 발명은
EP153R 유전자 및 K145R 유전자가 각각 완전히 결실되고,
EP402R 유전자가, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 W99에 상응하는 EP402R 단백질 중의 위치의 아미노산을 D로 변이시키는 돌연변이를 포함하는 것인 ASFV를 제공한다.
한 실시양태에서, 본 발명은 EP153R 유전자 및 K145R 유전자가 각각 완전히 결실되고, 서열식별번호 33의 서열을 포함하는 EP402R 단백질을 포함하는 것인 ASFV를 제공한다.
한 실시양태에서, 본 발명은 EP153R 유전자, EP402R 유전자 및 K145R 유전자가 각각 완전히 결실된 것인 ASFV를 제공한다.
한 실시양태에서, 본 발명은
ASFV 게놈이 Georgia 2007/1 균주의 것과 동일하되,
단, 예외적으로,
EP153R 유전자 및 K145R 유전자가 각각 완전히 결실되고,
EP402R 유전자가 EP402R 단백질의 Q96을 R로 변이시키는 돌연변이를 포함하는 것인 ASFV를 제공한다.
한 실시양태에서, 본 발명은 EP153R 유전자 및 K145R 유전자가 각각 완전히 결실되고, 서열식별번호 33의 서열을 포함하는 EP402R 단백질을 포함하고, 여기서, ASFV의 게놈은 Georgia 2007/1 균주의 것에 상응하는 것인 ASFV를 제공한다.
의학적 용도, 백신 및 제약 조성물
본 발명에서, 대상체에서 질환을 치료 및/또는 예방하는 데 사용하기 위한 본 발명의 ASF 바이러스를 제공한다. 본 발명은 또한 대상체에서의 질환 치료 및/또는 예방용 위한 의약의 제조를 위한 본 발명의 ASF 바이러스의 용도를 제공한다. 적합하게, 질환은 아프리카 돼지 열병이다.
본 발명은 또한 본 발명의 약독화된 ASF 바이러스를 포함하는 백신을 제공한다.
본원에서 사용되는 바, 용어 "백신"은 대상체에게 투여될 때, 방어 면역 반응을 유도하거나, 자극하는 제제를 지칭한다. 일부 실시양태에서, 본 발명의 백신은 부분적으로 방어 면역 반응을 유도한다. 일부 실시양태에서, 백신은 ASF 증상의 중증도 및/또는 지속 기간을 감소시키지만, ASF 증상을 완전히 폐기시키지는 못한다. 백신은 유기체가 특정 질환, 본 경우에는 ASF에 면역성을 나타내도록 만들 수 있다. 따라서, 본 발명의 백신은 대상체에서 후속 ASF 바이러스 챌린지로부터 방어하는 면역 반응을 유도한다. 본 발명의 약독화된 ASFV를 포함하는 백신은 복수의 ASF 바이러스 유전자형에 대한 교차-방어 면역 반응을 유도할 수 있다. 한 실시양태에서, 단일 유전자형의 본 발명의 약독화된 ASFV를 포함하는 백신은 복수의 ASF 바이러스 유전자형에 대한 교차-방어 면역 반응을 유도할 수 있다.
백신은 복수의 약독화된 ASF 바이러스를 포함할 수 있다. 복수의 약독화된 ASF 바이러스는 복수의 상이한 분리주, 예를 들어, 독성이 높거나, 알려지지 않은 상이한 분리주에 상응할 수 있다. 상기 백신은 복수의 ASF 바이러스 유전자형에 대한 교차-방어 면역 반응을 유도할 수 있다.
백신은 아프리카 돼지 열병 예방에 유용할 수 있다. 따라서, 본 발명은 대상체에서 아프리카 돼지 열병을 치료 및/또는 예방하는 데 사용하기 위한 본 발명의 백신을 제공한다.
본 발명은 또한 본 발명의 하나 이상의 약독화된 ASF 바이러스(들)를 포함하는 제약 조성물을 제공한다. 제약 조성물은 아프리카 돼지 열병의 치료를 위해 사용될 수 있다.
백신 또는 제약 조성물은 본 발명의 하나 이상의 약독화된 ASF 바이러스(들) 및 임의적으로, 하나 이상의 애주번트, 부형제, 담체 및 희석제를 포함할 수 있다. 제약 부형제, 담체 또는 희석제의 선택은 의도된 투여 경로 및 표준 제약 관행과 관련하여 선택될 수 있다. 제약 조성물은 담체, 부형제, 또는 희석제로서 (또는 그에 추가로) 임의의 적합한 결합제(들), 활택제(들), 현탁화제(들), 코팅제(들), 가용화제(들) 및 다른 캐리어 작용제를 포함한다. 제약 조성물은 전형적으로 제조 및 보관 조건 하에서 멸균성이고, 안정하여야 한다. 비경구 투여용 제제는 현탁제, 액제, 유성 또는 수성 비히클 중의 에멀젼, 페이스트, 및 이식가능한 지속 방출형 또는 생분해성 제제를 포함하나, 이에 제한되지 않는다. 멸균 주사용 제제는 비경구적으로 허용되는 비독성 희석제 또는 용매를 사용하여 제조될 수 있다. 본 발명의 제약 조성물은 사용된 투여량 및 농도에서 대상체에게 비독성인, 제약상 허용되는 분산화제, 습윤화제, 현탁화제, 등장제, 코팅제, 항박테리아제 및 항진균제, 담체, 부형제, 염, 또는 안정제를 포함할 수 있다. 바람직하게, 상기 조성물은 예를 들어, 비경구 (예컨대, 피하, 진피내, 또는 정맥내 주사) 또는 경막내 투여와 같은, 주어진 투여 방법 및/또는 투여 부위와 화합성을 나타내는, 질환 치료에 사용하기 위한 제약상 허용되는 담체 또는 부형제를 추가로 포함할 수 있다.
백신 또는 제약 조성물은 본 발명의 하나 이상의 약독화된 ASF 바이러스(들)를 유효량으로 포함할 수 있다.
한 실시양태에서, 본 발명은 대상체에게 투여될 때, 병독성 ASF 바이러스로의 후속 챌린지로부터 방어하는 면역 반응을 유도하는 본 발명의 약독화된 ASF 바이러스를 제공한다. 한 실시양태에서, 본 발명은 대상체에 투여될 때, 백신의 약독화된 ASF 바이러스에 대한 상이한 유전자형의 병독성 ASF 바이러스로의 후속 챌린지로부터 방어하는 면역 반응을 유도하는 본 발명의 약독화된 ASF 바이러스를 제공한다. 한 실시양태에서, 본 발명은 대상체에 투여될 때, 임의의 유전자형의 병독성 ASF 바이러스로의 후속 챌린지로부터 방어하는 면역 반응을 유도하는 본 발명의 약독화된 ASF 바이러스를 제공한다. 따라서, 본 발명은 아프리카 돼지 열병이 백신의 ASF 바이러스와 상이한 유전자형의 ASF 바이러스에 의해 유발되는 것인, 아프리카 돼지 열병 치료 및/또는 예방에서 사용하기 위한, 약독화된 ASF 바이러스를 포함하는 백신을 제공한다. 한 실시양태에서, 본 발명은 아프리카 돼지 열병이 임의의 유전자형의 ASF 바이러스에 의해 유발되는 것인, 아프리카 돼지 열병 치료 및/또는 예방에서 사용하기 위한, 약독화된 ASF 바이러스를 포함하는 백신을 제공한다. 한 실시양태에서, 백신의 ASF 바이러스는 유전자형 II, 예컨대, Georgia 2007/1 균주에 상응하고, 백신은 유전자형 I, II, III, IV, V, VI, VII, VIII, IX, X 및/또는 XIV로의 감염에 대해 방어적이다. 한 실시양태에서, 백신의 ASF 바이러스는 유전자형 II, 예컨대, Georgia 2007/1 균주에 상응하고, 백신은 유전자형 I, IX, X, XIV, 및/또는 VIII로의 감염에 대해 방어적이다. 한 실시양태에서, 백신의 ASF 바이러스는 유전자형 II, 예컨대, Georgia 2007/1 균주에 상응하고, 백신은 유전자형 I, IX, 및/또는 X으로의 감염에 대해 방어적이다.
예방/치료 방법
본 발명은 또한 유효량의 본 발명의 약독화된 바이러스, 백신 또는 제약 조성물을 대상체에게 투여함으로써 대상체에서 ASF를 예방 및/또는 치료하는 방법을 제공한다.
"예방하는"이라는 용어는 ASF의 발병을 방지, 지연, 방해 또는 저해하는 것을 지칭하는 것으로 의도된다. 예를 들어, 백신은 감염성 ASFV가 세포에 진입할 가능성을 예방하거나, 또는 감소시킬 수 있다. 백신은 ASF 증상의 중증도 및/또는 지속 기간을 감소시킬 수 있다. 백신은 ASF 증상을 완전히 폐기시킬 수 있다.
"치료하는"이라는 용어는 기존 ASF 감염의 적어도 하나의 증상을 감소 또는 완화시키는 것을 지칭하는 것으로 의도된다.
대상체는 ASF 감염에 걸리기 쉬운 임의의 동물일 수 있다. ASF에 걸리기 쉬운 동물로는 가축용 돼지, 와트호그, 부시피그 및 진드기를 포함한다.
본 발명에 따라 백신접종받는 대상체는 가축용 돼지일 수 있다.
적합하게, 본원에 정의된 방어 면역은 예컨대, 백신접종받은 어미 돼지와 같은 백신접종받은 대상체로부터 초유를 먹인 새끼 돼지에게 부여될 수 있다.
투여
본 발명의 백신은 예컨대, 근육내 주사와 같은 임의의 편리한 경로에 의해 투여될 수 있다. 다른 적합한 투여 경로로는 비내, 경구, 피하, 경피 및 질 (예컨대, 인공 수정 동안)을 포함한다. 한 실시양태에서, 경구 투여는 동물 사료 또는 음용수에 백신을 첨가하는 것을 포함한다. 또 다른 실시양태에서, 백신은 야생 동물용 미끼, 예를 들어, 멧돼지, 야생 돼지, 부시피그 또는 와트호그에 적합한 미끼에 첨가될 수 있다.
돼지 면역화를 위한 용량은 돼지당 약 103 내지 약 106 HAD50 또는 TCID50일 수 있다. 돼지 면역화를 위한 용량은 돼지당 약 103 내지 약 106 TCID50일 수 있다. 돼지 면역화를 위한 용량은 돼지당 104 HAD50 또는 TCID50 미만일 수 있다. 예를 들어, 용량은 102-103 HAD50 또는 TCID50일 수 있다. 용량은 돼지당 약 102 HAD50 또는 TCID50일 수 있다. 용량은 수의사의 합리적인 판단 범위 내에서 수의사가 결정할 수 있다.
백신은 프라임-부스트 요법에 따라 투여될 수 있다. 예를 들어, 1차 접종 후, 대상체는 일정 시간 (예컨대, 약 7, 14, 21 또는 28일) 후에 2차 부스팅 투여를 받을 수 있다. 전형적으로, 부스팅 투여는 프라이밍 투여보다 더 높은 용량이다. 부스팅 용량은 돼지당 약 103 내지 약 106 HAD50 또는 TCID50일 수 있다. 부스팅 용량은 돼지당 약 103 내지 약 106 TCID50일 수 있다.
바이러스 제조 방법
본 발명은 또한 EP402R 단백질의 리간드 결합 도메인 중의 하나 이상의 아미노산을 변이시키는 단계를 포함하고, 여기서, 아미노산 변이는 EP402R 단백질의 리간드 결합을 파괴시키는 것인, 본 발명의 ASF 바이러스를 제조하는 방법을 제공한다.
본 발명은 또한 EP402R 단백질의 리간드 결합 도메인 중의 하나 이상의 아미노산 변이를 변이시키는 단계를 포함하고, 여기서, 아미노산 변이는 EP402R 단백질의 리간드 결합을 파괴시키는 것인, 혈구흡착을 유도하는 ASF 바이러스의 능력을 감소시키는 방법을 제공한다.
EP402R 단백질의 리간드 결합 도메인 중의 아미노산 변이는 본원에 기재된 아미노산 변이 중 임의의 것일 수 있다. 상기 아미노산 변이는 본원에 기재된 바와 같이 ASFV 게놈을 돌연변이시킴으로써 이루어질 수 있다.
한 실시양태에서, 본 방법은 Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96 및/또는 W99에 상응하는 위치의 EP402R 단백질 중의 하나 이상의 아미노산을 변이시키는 단계를 포함한다.
본 발명은 또한 EP153R 및 EP402R 유전자의 발현 및/또는 활성을 파괴시키는 단계를 포함하는, ASF 바이러스를 약독화시키는 방법을 제공한다. 적합하게, 본 방법은 혈구흡착을 매개하는 EP153R 유전자 및/또는 EP402R 유전자의 능력을 파괴시키는 단계를 포함한다.
유전자 발현 및/또는 활성 파괴는 본원에 기재된 임의의 방식으로 ASFV 게놈을 돌연변이시킴으로써 달성될 수 있다.
한 실시양태에서, 본 방법은 DIVA 돌연변이를 ASF 바이러스 내로 도입하는 단계를 추가로 포함한다. 적합하게, DIVA 돌연변이는 K145R 유전자의 발현을 파괴시킨다. 적합하게, K145R은 적어도 부분적으로 결실, 바람직하게, 완전히 결실된다. 적합하게, K145R 유전자는 중단된다. 적합하게, DIVA 돌연변이는 B125R 유전자의 발현을 파괴시킨다. 적합하게, B125R은 적어도 부분적으로 결실, 바람직하게, 완전히 결실된다. 적합하게, B125R 유전자는 중단된다.
ASFV를 제조 및/또는 약독화시키는 방법의 한 실시양태에서, EP153R 유전자는 적어도 부분적으로 결실, 바람직하게, 완전히 결실된다. 한 실시양태에서, EP153R 유전자는 중단된다.
ASFV를 제조 및/또는 약독화시키는 방법의 한 실시양태에서, EP402R 유전자는 적어도 부분적으로 결실, 바람직하게, 완전히 결실된다. 한 실시양태에서, EP402R 유전자는 중단된다. 적합하게, 본 방법은 하나 이상의 돌연변이를 포함하지 않는 상응하는 ASF 바이러스와 비교하여 EP402R 단백질의 표면 발현을 감소시키는 하나 이상의 돌연변이를 EP402R 유전자에 도입시키는 단계를 포함한다. 적합하게, 본 방법은 EP402R 단백질에 의한 리간드 결합을 파괴시키는 하나 이상의 돌연변이를 EP402R 유전자에 도입시키는 단계를 포함한다. 적합하게, 본 방법은 EP402R 단백질의 리간드 결합 도메인 중의 하나 이상의 아미노산을 변이시키는 하나 이상의 돌연변이를 EP402R 유전자에 도입시키는 단계를 포함한다. 적합하게, 하나 이상의 아미노산은 상이한 아미노산으로 변이된다. 적합하게, 아미노산의 상이한 아미노산으로의 변이는 EP402R 상의 결합 표면을 변경함으로써 EP402R과 그의 리간드 사이의 상호작용을 직접 억제한다.
한 실시양태에서, 본 방법은 Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96 및/또는 W99에 상응하는 위치의 EP402R 단백질 중의 아미노산을 변이시키는 단계를 포함한다. 적합하게, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96에 상응하는 위치의 EP402R 단백질 중의 아미노산은 R로, 또는 R의 보존적 대체인 아미노산으로 변이되고/거나, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 W99에 상응하는 위치의 아미노산은 D, 또는 D의 보존적 대체인 아미노산으로 변이된다. 적합하게, Q96에 상응하는 위치의 아미노산은 H, K 또는 R로 변이되고/거나, W99에 상응하는 위치의 아미노산은 D, E, N 또는 Q로 변이된다. 적합하게, Q96에 상응하는 위치의 아미노산은 R로 변이되고/거나, W99에 상응하는 위치의 아미노산은 D로 변이된다.
한 실시양태에서, 본 발명은 각각의 EP153R 및 K145R 유전자를 완전히 결실시키는 단계, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96에 상응하는 위치의 아미노산을 R로 변이시키고/거나, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 W99에 상응하는 위치의 아미노산을 D로 변이시키는 단계를 포함하는, ASF 바이러스를 약독화시키는 방법을 제공한다. 한 실시양태에서, 본 발명은 각각의 EP153R 및 K145R 유전자를 완전히 결실시키는 단계, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96에 상응하는 위치의 아미노산을 R로 변이시키는 단계를 포함하는, ASF 바이러스를 약독화시키는 방법을 제공한다.
한 실시양태에서, 본 발명의 ASF 바이러스를 제조 및/또는 약독화시키는 방법은 임의의 유전자형의 ASF 바이러스 (즉, 유전자형 I 내지 XXIV 중 임의의 것의 ASF 바이러스)에 적용될 수 있다. 다시 말해, 임의의 유전자형의 ASF 바이러스는 본 발명의 방법의 변형의 대상이 될 수 있다. 임의의 유전자형의 ASF 바이러스는 본 방법에서 사용될 수 있다. 한 실시양태에서, 본 발명의 ASF 바이러스를 제조 및/또는 약독화시키는 방법은 유전자형 II의 ASF 바이러스에 적용될 수 있다. 한 실시양태에서, 본 발명의 ASF 바이러스를 제조 및/또는 약독화시키는 방법은 Georgia 2007/1 균주의 ASF 바이러스에 적용될 수 있다.
한 실시양태에서, 본 발명은 각각의 EP153R 및 K145R 유전자를 완전히 결실시키는 단계, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96을 R로 변이시키고/거나, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 W99를 D로 변이시키는 단계를 포함하는, Georgia 2007/1 균주의 ASF 바이러스를 약독화시키는 방법을 제공한다. 한 실시양태에서, 본 발명은 각각의 EP153R 및 K145R 유전자를 완전히 결실시키는 단계, 및 Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96을 R로 변이시키는 단계를 포함하는, Georgia 2007/1 균주의 ASF 바이러스를 약독화시키는 방법을 제공한다.
바이러스 유전자의 돌연변이 방법은 관련 기술분야에에 공지되어 있다. 특히, 바이러스 유전자의 결실 방법은 관련 기술분야에 공지되어 있다. 예를 들어, 관련 유전자(들)가 누락된 전달 벡터가 생성되고, 바이러스 감염 세포를 형질감염시키는 데 사용되는 상동성 재조합이 사용될 수 있다. 이어서, 서열의 새로운 부분을 발현하는 재조합 바이러스가 선택될 수 있다. 예를 들어, ATG 시작 코돈의 결실에 의해 유전자 발현을 중단하기 위해 유사한 절차가 사용될 수 있다.
일부 실시양태에서, ASF 바이러스를 약독화시키는 방법은 하기 유전자: MGF 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L; MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R; 및 MGF 505 1R, 2R 및 6R 중 하나 이상의 기능을 보유하는 단계를 포함할 수 있다. 적합하게, 하기 유전자: MGF 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L; MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R; 및 MGF 505 1R, 2R 및 6R 중 2개 이상, 예컨대, 3개 이상, 4개 이상, 5개 이상, 6개 이상, 7개 이상, 8개 이상, 9개 이상, 10개 이상, 11개 이상, 12개 이상, 13개 이상, 14개 이상, 15개 이상, 16개 이상, 17개 이상, 18개 이상, 19개 이상, 20개 이상, 21개, 또는 22개의 것의 기능이 보유된다. 한 실시양태에서, ASF 바이러스를 약독화시키는 방법은 하기 유전자: MGF 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L; MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R; 및 MGF 505 1R, 2R 및 6R 모두의 기능을 보유하는 단계를 포함할 수 있다.
유전자의 "기능을 보유한다"는 것은 약독화 과정에서 유전자의 발현 및 활성이 영향을 받지 않는다는 것을 의미한다. 생성된 약독화된 바이러스는 유전자의 기능성 버전을 발현하여야 한다. 적합하게, 그 기능이 보유되어야 하는 유전자 약독화 방법에 의해 변경되지 않는다. 적합하게, 그 기능이 보유되어야 하는 유전자의 서열은 약독화 방법에 의해 변경되지 않는다.
본 개시내용은 본원에 개시된 예시적인 방법 및 물질에 의해 제한되지는 않으며, 본원에 기재된 것과 유사하거나, 또는 등가인 임의의 방법 및 물질이 본 개시내용의 실시양태의 실시 또는 시험에서 사용될 수 있다. 수치 범위는 그 범위를 정의하는 수치를 포함한다. 달리 명시되지 않는 한, 각각 임의의 핵산 서열은 5'에서 3' 방향으로 좌측에서 우측으로 작성되고; 아미노산 서열은 각각 아미노에서 카르복시 방향으로 좌측에서 우측으로 작성된다.
본원 및 첨부된 청구범위에 사용된 바와 같이, 단수 형태 "하나"는 문맥상 달리 명확하게 지시하지 않는 한, 복수의 지시대상을 포함한다는 점에 주의하여야 한다.
본원에 사용된 바와 같이, "포함하는," "포함한다" 및 "~으로 구성된"이라는 용어는 "수반하는," "수반한다" 또는 "함유하는," "함유한다"와 동의어이고, 포괄적이거나, 또는 개방적이고, 추가의, 언급되지 않은 구성원, 요소 또는 방법 단계를 배제시키지 않는다. "포함하는," "포함한다" 및 "~으로 구성된"이라는 용어는 또한 "~으로 이루어진"이라는 용어도 포함한다.
본원에 논의된 공개문헌은 단지 본 출원의 출원일 이전에 상기 공개문헌의 개시를 위해서만 제공된다. 본원의 어느 것도 상기 공개문헌이 본원에 첨부된 청구범위에 대한 선행 기술을 구성한다는 것을 인정하는 것으로 해석되어서는 안된다.
추가 측면
본 발명은 또한 하기 넘버링된 항(paragraph (para))에서 정의된 바와 같은 추가 측면을 제공한다.
1. 유전자 EP153R 및 K145R의 발현 및/또는 활성이 파괴된, 약독화된 아프리카 돼지 열병 (ASF) 바이러스.
2. 제1항에 있어서, EP402R 유전자의 발현 및/또는 활성이 파괴되지 않은 것인, 약독화된 ASF 바이러스.
3. 제1항 또는 제2항에 있어서, 하기 유전자:
다중유전자 패밀리 (MGF) 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L,
MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R, 및
MGF 505 1R, 2R 및 6R 중 하나 이상의 기능성 버전을 포함하는 것인 약독화된 ASF 바이러스.
4. 임의의 상기 항에 있어서, K145R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실된 것인 약독화된 ASF 바이러스.
5. 제4항에 있어서, K145R 유전자가 중단된 것인 약독화된 ASF 바이러스.
6. 임의의 상기 항에 있어서, EP153R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실된 것인 약독화된 ASF 바이러스.
7. 임의의 상기 항에 있어서, EP153R 유전자가 중단된 것인 약독화된 ASF 바이러스.
8. 임의의 상기 항에 있어서, EP153R 및 K145R 이외의 다른 모든 ASF 바이러스 유전자의 기능성 버전을 포함하는 약독화된 ASF 바이러스.
9. 임의의 상기 항에 있어서, 약독화된 ASF 바이러스의 게놈이 유전자형 II에 상응하거나, 또는 본질적으로 그에 상응하는 것인 약독화된 ASF 바이러스.
10. 제9항에 있어서, 약독화된 ASF 바이러스의 게놈이 Georgia 2007/1 균주의 것에 상응하거나, 또는 본질적으로 그에 상응하는 것인 약독화된 ASF 바이러스.
11. 제1항 내지 제10항 중 어느 항에 있어서, 대상체에서 질환을 치료 및/또는 예방하는 데 사용하기 위한 ASF 바이러스.
12. 대상체에서의 질환 치료 및/또는 예방용 의약의 제조를 위한 제1항 내지 제10항 중 어느 항에 따른 ASF 바이러스의 용도.
13. 제1항 내지 제10항 중 어느 항에 따른 ASF 바이러스를 포함하는 제약 조성물.
14. 제13항에 있어서, 대상체에서 질환을 치료 및/또는 예방하는 데 사용하기 위한 제약 조성물.
15. 제11항에 있어서, 제12항에 있어서, 또는 제14항에 있어서, 질환이 아프리카 돼지 열병인, ASF 바이러스, ASF 바이러스의 용도 또는 제약 조성물.
16. 제1항 내지 제10항 중 어느 항에 따른 ASF 바이러스를 포함하는 백신.
17. 제16항에 있어서, 대상체에서 아프리카 돼지 열병을 치료 및/또는 예방하는 데 사용하기 위한 백신.
18. 제17항에 있어서, 아프리카 돼지 열병이 백신의 ASF 바이러스와 상이한 유전자형의 ASF 바이러스에 유발되는 것인, 백신.
19. 대상체에게 유효량의, 제13항에 따른 제약 조성물, 또는 제16항에 따른 백신을 투여하는 단계를 포함하는, 대상체에서 아프리카 돼지 열병을 치료 및/또는 예방하는 방법.
20. 제11항에 있어서, 제12항에 있어서, 제14항에 있어서, 제17항에 있어서, 또는 제19항에 있어서, 대상체가 가축용 돼지인, ASF 바이러스, ASF 바이러스의 용도, 제약 조성물, 백신, 또는 방법.
21. 제17항, 제18항 또는 제20항 중 임의의 항에 있어서, 또는 제19항 또는 제20항에 있어서, 백신이 프라임-부스트 요법에 따라 투여되는 것인, 백신, 또는 방법.
22. EP153R 및 K145R 유전자의 발현 및/또는 활성을 파괴시키는 단계를 포함하는, ASF 바이러스를 약독화시키는 방법.
23. 제22항에 있어서, K145R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실되는 것인 방법.
24. 제23항에 있어서, K145R 유전자가 중단되는 것인 방법.
25. 제22항 내지 제24항 중 어느 항에 있어서, EP153R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실되는 것인 방법.
26. 제22항 내지 제25항 중 어느 항에 있어서, EP153R 유전자가 중단되는 것인 방법.
이제 본 발명은 실시예를 통해 추가로 설명될 것이며, 이는 관련 기술분야의 통상의 기술자가 본 발명을 수행하는 데 도움을 주기 위한 것이며, 어느 방식으로든 본 발명의 범주를 제한하는 것으로 의도되지 않는다.
실시예
실시예
1 - HAD를 감소시키는
EP402R
/
CD2v
돌연변이체 확인
아프리카 돼지 열병 바이러스 (ASFV) Benin 분리주 EP402R 단백질 (CD2v)에서 돌연변이화하고, 상기 돌연변이가 혈구흡착 (HAD)에 미치는 효과에 대해 시험하였다.
CD2v의 세포외, N-말단, IgG 유사, 리간드 결합 도메인의 모델을 생성하고, CD2v가 그의 리간드에 결합하는 데 관여하는 기능성 아미노산 잔기를 예측하는 데 사용하였다. 이들 잔기를 개별적으로 돌연변이시켜 돌연변이체 CD2v 단백질 세트를 생성하였다.
Vero 세포를 T7RNA 폴리머라제를 발현하는 변형된 백시니아 바이러스 앙카라로 감염시키고, C-말단 HA 에피토프 태그가 있는 야생형 또는 돌연변이체 CD2v 전장 단백질을 발현하는 플라스미드 (pcDNA3)로 형질감염시켰다. 돼지 적혈구를 첨가하고, 적혈구의 표면에의 부착에 대해 세포를 관찰하였다. 투과성 세포를 사용하여 공초점 현미경법에 의해 및 HA 태그를 인식하는 항체 및 2차 항체를 사용하여 웨스턴 블롯팅에 의해 야생형 또는 돌연변이체 CD2v 단백질의 발현을 모두 확인하였다. 야생형 또는 돌연변이체 CD2v의 세포 표면 발현은 또한 야생형 CD2v 유전자를 함유하는 약독화된 ASFV로 면역화된 돼지로부터의 혈청, 이어서, 2차 항체로 비투과성 세포를 염색함으로써 확인하였다 (도 1).
Benin CD2v 중 잔기 E99 또는 Y102의 돌연변이는 HAD를 폐기하였다. 도 2는 HAD 검정법으로부터의 예시적인 이미지를 보여주는 것이다. 도 2a는 야생형 Benin CD2v를 발현하는 플라스미드로 형질감염된 세포를 보여주는 것이다. 적혈구의 HAD는 3개의 세포 주위에서 관찰된다. 도 2b는 Y102 잔기가 D로 돌연변이된 CD2v를 발현하는 세포를 보여주는 것이다. 한 세포 주위에서 부분적인 HAD가 관찰된다. 도 2c는 잔기 E99가 R로 돌연변이된 CD2v를 발현하는 세포를 보여주는 것이다. HAD는 관찰되지 않는다.
Benin CD2v 잔기 E99는 다양한 유전자형의 상이한 ASFV 분리주로부터의 CD2v 리간드 결합 도메인의 아미노산 서열의 정렬에 의해 제시된 바와 같이, ASFV에서 강력하게 보존된다 (도 3). 다른 분리주의 등가의 잔기 (도 3에서 황색으로 강조 표시)는 동일하거나 (E), 또는 동일한 전하를 가진다 (Q).
Georgia CD2v 중의 Benin CD2v E99에 상응하는 잔기인 Q96은 R로 돌연변이되었고, 상기 기재된 HAD 검정법을 사용하여 HAD를 유도할 수 있는 돌연변이체 단백질의 능력을 시험하였다 (Vero 세포에서 플라스미드로부터 발현된 야생형 및 돌연변이체 CD2v 단백질). Georgia CD2v에서 Q96의 돌연변이는 HAD를 폐기하였다. 도 4는 돼지 적혈구가 있는 Vero 세포의 HAD 검정법으로부터의 예시적인 이미지를 보여주는 것이다. 도 4a는 야생형 Benin CD2v를 발현하는 플라스미드로 형질감염된 Vero 세포를 보여주는 것이다. 적혈구의 HAD는 4개의 세포 주위에서 관찰된다. 도 4b는 야생형 Georgia CD2v를 발현하는 Vero 세포를 보여주는 것이다. HAD는 2개의 세포 주위에서 관찰된다. 도 4c는 잔기 Q96이 R로 돌연변이된 Georgia CD2v를 발현하는 Vero 세포를 보여주는 것이다. HAD는 관찰되지 않는다. 도 4d는 형질감염되지 않은 Vero 세포를 보여주는 것이다. HAD는 관찰되지 않는다.
동일한 검정법을 사용하여, 하기 돌연변이가 Benin에서 HAD에 영향을 미치는 것으로 결정되었다: N16R, I 19R, W21D, Y 76D, E99R, Y102D. 추가로, E99R + N108R의 조합이 Benin에서 HAD에 영향을 미치는 것으로 결정되었다.
하기 돌연변이가 Georgia에서 HAD에 영향을 미치는 것으로 결정되었다: S15R, W19D, Q96R, N104R, 및 K108D. 추가로, S15R + W19D 및 Q96R + N104R의 조합이 Georgia에서 HAD에 영향을 미치는 것으로 결정되었다.
하기 돌연변이가 N10 유전자형 IX에서 HAD에 영향을 미치는 것으로 결정되었다: W20D, R125D, Q112R + N121R.
실시예
2 - DIVA
마커
스크리닝
백신접종받은 동물로부터의 감염된 동물 감별 (DIVA) 마커 역할을 하는 유전자의 경우, 유전자로부터 발현되는 단백질이 면역원성이어야 한다. 다시 말해, DIVA 단백질을 발현하는 바이러스로 감염된 대상체는 DIVA 단백질에 특이적으로 결합하는 항체를 생산하여야 한다. 이러한 방식으로, DIVA 백신 (DIVA 마커 유전자가 결여된 바이러스)으로 백신접종받은 동물은 백신접종받은 동물의 혈청이 DIVA 마커 단백질에 대한 항체를 포함하지 않기 때문에, 야생형 바이러스 (DIVA 마커 유전자를 발현)로 감염된 동물로부터 감별될 수 있는 반면, 감염된 동물의 혈청은 DIVA 마커 단백질에 대한 항체를 포함할 것다.
DIVA 마커 역할을 할 수 있는 ASFV 유전자의 선택은 세포에서 각 유전자를 발현하고, 생성된 단백질이 이전에 ASFV로 감염된 돼지로부터 채취한 혈청에 의해 검출될 수 있는지 여부를 시험함으로써 스크리닝하였다. 혈청에 의한 검출은 감염된 돼지에서 ASFV에 의해 발현된 단백질이 감염된 돼지에서 항체 반응을 유도했다는 것을 나타낼 것이다. 따라서, 상기 단백질은 DIVA 마커의 후보였다.
특히, HA 또는 V5 에피토프 태그에 융합된 개별 ASFV 유전자 (공지된 필수 유전자 제외)를 코딩하는 71개의 플라스미드를 Vero 세포에 형질감염시켰다. 세포를 고정시키고, 투과시키고, 상이한 ASFV 균주로 감염된 돼지의 항혈청으로 염색한 후, 형광 표지된 2차 항체로 염색하였다. 공초점 현미경을 사용하여 발현된 유전자가 혈청에 의해 검출될 수 있는지 여부를 평가하였다. 동시에, 세포를 ASFV 유전자에 융합된 HA 또는 V5 태그에 대한 항체 및 다른 형광 표지된 2차 항체로 염색하여 단백질의 발현을 확인하였다.
세포 염색에 사용된 돼지 혈청은 하기 ASFV 균주로 면역화된 면역화 연구의 돼지로부터의 것이었다: BeninΔDP148R (돼지 5마리), BeninΔMGF (돼지 6마리), OURT88/3 (돼지 5마리) 및 GeorgiaΔMGF (돼지 4마리). 각 돼지에 대해, 면역화 전 혈청 샘플 (대조군으로서) 및 면역화 후, 챌린지 전 혈청 샘플을 사용하였다.
유전자의 초기 스크리닝은 BeninΔDP148R 면역화된 돼지로부터의 혈청 (0일째의 면역화 전 혈청, 면역화 후 38일째의 면역화 후 혈청)을 사용하여 수행하였다. ASFV 유전자 CP204L, B646L 및 E183L을 양성 대조군으로 사용하고, 면역화 후 혈청을 사용하여 검출하였다. 면역화 전 혈청은 어떤 유전자도 검출하지 못했다.
6개의 ASFV 유전자가 하기 표 7에 제시된 바와 같이 BeninΔDP148R 면역화 후 혈청을 사용하여 검출되었다 (++는 강한 검출을 나타내고, +는 약한 검출을 나타내고, -는 비검출을 나타낸다).
<표 7>
이어서, 초기 스크린에서 검출된 6개의 ASFV 유전자를 다른 3개의 면역화 연구의 돼지 혈청을 이용하여 시험하였다.
하기 표 8은 BeninΔMGF 바이러스로 면역화된 돼지 6마리로부터의 면역화 후 혈청을 사용한 ASFV 유전자의 검출을 보여주는 것이다 (15일에 부스팅, 면역화 후 38일째에 면역화 후 혈청 채취; 면역화 전 혈청은 음성이었다).
<표 8>
하기 표 9는 OURT88/3 바이러스로 면역화된 돼지 5마리로부터의 면역화 후 혈청을 사용한 ASFV 유전자의 검출을 보여주는 것이다 (면역화 후 20일째에 면역화 후 혈청 채취; 면역화 전 혈청은 음성이었고, 단, 돼지 2는 제외).
<표 9>
하기 표 10은 GeorgiaΔMGF 바이러스로 면역화된 돼지 4마리로부터의 면역화 후 혈청을 사용한 ASFV 유전자의 검출을 보여주는 것이다 (면역화 후 34일째에 면역화 후 혈청 채취; -3일째 채취된 면역화 전 혈청은 음성이었다). 돼지 2마리 (a)는 103 GeorgiaΔMGF로 면역화시켰고; 돼지 2마리 (b)는 104 GeorgiaΔMGF로 면역화시켰다.
<표 10>
K145R 단백질은 혈청의 65%에서 검출되었고, B125R은 혈청의 75%에서 검출되었다. B125R, B175L, E184L, H339R, K145R 및 M448R 유전자는 각각 개별적으로 결실되었다. B175L, E184L, H339R 또는 M448R 유전자는 결실될 수 없으며, 이는 바이러스 복제에 필수적이라는 것을 시사하는 것이다. 따라서, 스크린을 통해 K145R 및 B125R 유전자가 가장 유망한 잠재적 DIVA 마커인 것으로 확인되었다.
도 5는 세포에서 발현되는 K145R 및 B125R을 보여주는 것이다. Vero 세포를, HA 에피토프 태그가 프레임 내에서 융합된 K145R 또는 B125R을 발현하는 플라스미드로 형질감염시켰다. 발현된 단백질은 HA에 대한 항체를 사용하여 투과된 세포에서 검출되었고, 공초점 현미경을 사용하여 이미징하였다. 녹색 염색은 발현된 단백질을 나타내고, 청색 DAPI 염색은 DNA를 검출한다. 도 5a는 K145R을 보여주고, 도 5b는 B125R을 보여주는 것이다.
도 6은 Vero 세포에서 발현되고, ASFV로 면역화된 돼지로부터의 항혈청에 의해 검출된 K145R(도 6a) 및 B125R(도 6b)의 스크리닝 과정의 예를 보여주는 것이다. 세포를 고정시키고, 투과시키고, 발현된 단백질을 검출하기 위해 항-HA (적색)로 및 약독화된 유전자형 I Benin97/1 유전자 결실 ASFV 균주 (녹색)로 면역화된 돼지의 혈청으로 염색하였다. 면역화 전 및 면역화 후 38일째에 수집된 혈청으로 염색된 세포의 이미지가 제시되어 있다. DNA는 청색으로 염색된다.
실시예
3 - 비-HAD
ASFV
GeorgiaΔK145RΔEP153RCD2vQ96R의 생성
상기 실시예에 기재된 관찰결과에 기초하여, K145R 및 EP153R 유전자가 결실되고, EP402R/CD2v 단백질이 Q96R 아미노산 치환을 포함하도록 돌연변이된 ASFV를 생성하였다. Georgia 2007/1 균주 (ASFV 유전자형 II의 균주)를 사용하였다. 따라서, ASFV는 GeorgiaΔK145RΔEP153RCD2vQ96R로 명명되었다.
HAD를 유도할 수 있는 GeorgiaΔK145RΔEP153RCD2vQ96R의 능력을 시험하였다. 돼지 골수 세포를 GeorgiaΔK145RΔEP153RCD2vQ96R 또는 대조군으로서 야생형 Georgia 2007/1로 감염시키고, 돼지 적혈구를 첨가하고, 표면에의 적혈구 부착에 대해 세포를 관찰하였다. HAD는 감염 후 1째일에 야생형 Georgia 2007/1로 감염된 세포에서 관찰된 반면 (도 7a - 적혈구가 감염된 세포 주위에 축적), 감염 후 1일째에 GeorgiaΔK145RΔEP153RCD2vQ96R로 감염된 세포에서는 HAD가 관찰되지 않았다 (도 7b).
실시예
4 - Georgia
ΔK145RΔEP153RCD2vQ96R은
약독화된
것이고,
챌린지에
대한 방어를 유도한다.
백신접종 실험 프로토콜
체중이 17 내지 19 kg으로 다양한 7주령된, 6마리 라지 화이트(Large White)/랜드레이스(Landrace) 돼지 그룹 (그룹 K)을 GeorgiaΔK145RΔEP153RCD2vQ96R을 이용하여 1 ml당 104 TCID50으로 근육내 경로에 의해 면역화시키고, 21일 후 동일한 용량으로 동일한 경로에 의해 부스팅하였다. 추가로 18일 경과 후, 그룹 K의 면역화된 돼지 및 대조군의 비-면역 돼지 3마리 (그룹 M)를 병독성 유전자형 II ASF 바이러스 Georgia 2007/1을 이용하여 1 ml당 103 TCID50으로 근육내 경로에 의해 챌린지하였다. 추가로 20일 경과 후, 돼지에 대한 임상 시험을 중단하였다. 본 실험 프로토콜은 도 8에 도시되어 있다.
체온 및 임상 점수
돼지의 체온 (도 9)와 임상 점수 (도 10)는 표준 점수화 체계를 사용하여 매일 기록하였다 (King et al., 2011). 임상 점수는 체온 및 예컨대, 식욕 상실 또는 무기력과 같은 다른 징후를 포함한다.
비-면역 돼지인 대조군 M은 챌린지 후 4일째부터 체온 상승 (도 9a) 및 결식 및 무기력을 포함한 급성 ASFV의 전형적인 다른 임상 징후를 보였고, 챌린지 후 6일째 중간 정도의 중증도에서의 종점에서 안락사시켰다 (도 10a).
면역화된 그룹 K의 돼지 중 2마리는 면역화 후 11일째를 시작으로 2일 동안 체온이 40.6 초과로 일시적으로 상승하였다 (도 9b). 상기 돼지 및 그룹 K 중의 다른 모든 돼지는 부스트 후 또는 챌린지 후에 어떤 다른 임상 징후를 보이지 않았다 (도 10b).
이전 연구에서는 K145R 결실이 최소한의 직접적인 약독화 효과를 갖는 것으로 밝혀졌다.
바이러스혈증 데이터는 도 15에 제시되어 있다.
사후에 육안 병변의 점수화
부검시, 표준화된 점수화 체계에 따라 상이한 기관 및 충치의 육안적 병변을 점수화하였다. 도 11에서, 점수는 y축에 표시되고, 돼지 마리수는 x축에 표시되어 있다. 그룹 K의 돼지 (GeorgiaΔK145RΔEP153RCD2vQ96R로 면역화)는 병변이 거의 없었으며, 주로 신장 또는 하악 림프절이 약간 확대되어 있었다. 대조적으로, 그룹 M 중의 대조군 비-면역 돼지는 비대성 및 출혈성 림프절 및 비장 비대를 포함하는 급성 ASFV의 전형적인 병변을 보였다.
면역화된 돼지의 항체 반응
면역화 전 및 면역화 후 상이한 시점 (일째), 부스트 및 챌린지에 그룹 K의 돼지로부터 수집된 혈청을 상업적 경쟁 ELISA 검정법을 사용하여 주요 ASFV 캡시드 단백질 VP72/B646L에 대한 항체 수준을 시험하였다. 도 12에서 차단율(%)은 y축에 표시되고, 면역화 후 경과일수는 x축에 표시되어 있다. 상이한 돼지에 대한 데이터는 상이한 색상으로 표시한 바와 같이 제시되어 있다. 회색 선은 양성 혈청의 검출을 위해 제조사가 명시한 컷-오프 값을 나타낸다. 결과는 면역화 후 14일째까지 값이 모든 돼지에 대해 양성이었고, 수준은 플래토에 도달하였고, 실험 동안 유지된 것으로 나타났다.
세포 매개 면역 반응
GeorgiaΔK145RΔEP153RCD2vQ96R로의 면역화 전, 부스트 전 및 Georgia 2007/1 바이러스로의 챌린지 전에 그룹 K의 돼지로부터 말초 혈액 단핵 세포 (PBMC)를 수집하였다. PBMC를 ASFV로 자극하였고, 인터페론 감마 생산 세포의 개수를 ASFV에 대한 세포 면역 반응의 지표로서 측정하였다 (도 13).
PBMC를 모의 자극시키거나 (청색 막대), 또는 ASFV 유전자형 I Benin97/1 감염성 바이러스 (적색 막대) 또는ASFV 유전자형 II Georgia 2007/1 바이러스 (녹색 막대)로 자극시켰다. 인터페론 감마 생산 세포의 개수를 측정하였고, 106개 세포당 상기 세포의 개수는 y축에 표시되어 있다. 돼지 마리수는 x축에 제시되어 있다. 결과는 예상대로 면역화 전에는 검출가능한 IFN 감마 생산 세포가 매우 낮거나, 전혀 없는 것으로 나타났다 (도 13a). 부스트 전 21일째까지 IFN 감마 생산 세포의 개수는 자극에 사용된 ASFV 바이러스에 따라 약 100 내지 750개 세포 사이에서 다양하게 증가하였다 (도 13b). ASFV 자극 후 IFN 감마 생산 세포 개수는 챌린지 전 39일째 우수한 수준으로 유지되었다 (도 13c). IFN 감마 생산은 유전자형 I 및 유전자형 II 분리주, 둘 모두에 의해 자극되었고, 이는 교차-유전자형 세포 반응이 유도되었다는 것을 시사하는 것이다. 예상대로, 모의 자극은 검출가능한 반응을 일으키지 않았다.
도 14는 시간 경과에 따른, Georgia 2007/1 분리주를 사용한 자극 후의 상이한 돼지에 대한 IFN 감마 생산 세포 개수를 보여주는 것이다.
상기 명세서에서 언급된 모든 공개문헌은 본원에 참조로 포함된다. 본 발명의 기재된 방법 및 시스템의 다양한 수정 및 변형은 본 발명의 범주 및 정신을 벗어나지 않으면서 통상의 기술자에게 명백해질 것이다. 본 발명이 구체적인 바람직한 실시양태와 관련하여 기재되었지만, 청구된 바와 같은 본 발명은 그러한 구체적인 실시양태에 과도하게 제한되어서는 안된다는 것을 이해하여야 한다. 실제로, 바이러스학, 분자생물학 또는 관련 분야의 통상의 기술자에게 자명한 기재된 본 발명 수행 모드의 다양한 수정은 하기 청구범위의 범주 내에 포함되는 것으로 의도된다.
SEQUENCE LISTING
<110> The Pirbright Institute
University of Oxford
Kumamoto University
<120> VACCINE
<130> P120880PCT
<140> PCT/GB2021/050562
<141> 2021-03-05
<150> GB 2003292.6
<151> 2020-03-06
<150> GB 2003289.2
<151> 2020-03-06
<150> GB 2005878.0
<151> 2020-04-22
<150> GB 2005880.6
<151> 2020-04-22
<150> GB 2013541.4
<151> 2020-08-28
<160> 386
<170> PatentIn version 3.5
<210> 1
<211> 163
<212> PRT
<213> African swine fever virus
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Leu Asn Arg Pro Leu Ser Ile Phe Tyr Met Lys Gln Asn Leu Pro Arg
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Thr Tyr Thr Pro Pro Ile Arg Glu Leu Glu Tyr Trp Cys Thr Tyr Gly
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Ile Asn Ala
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Ile Lys Leu Phe Val Leu Trp Gly Ala Asn Ile Asn Tyr Gly Ile Ile
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Met Val Pro Ser Leu Gln Ser Phe Ala Lys Lys Val Leu Ala Ser Gln
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Gly Ala Asp Ile Asn Tyr Gly Leu Ile Cys Ala Asn Thr Pro Pro Ile
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Ala Tyr Val Ile Ile Arg Glu Ile Lys Ser Cys Ile His Trp Lys Leu
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Lys Asn Leu Ala Glu Asp Thr Asn Val Leu Ser Asn Ile Ser Asp Gly
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Phe Tyr Asn Met Asp Asn Leu Phe Phe Cys Ile Asp Leu Gly Ala Asp
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Ala Phe Glu Glu Ala Lys Ala Leu Ala Glu Gln Gln Asn Tyr Tyr Leu
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Ile Ser His Arg Leu Ser Leu Asp Ile Tyr Ser Pro Asp Ser Ser Leu
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Leu Thr Leu Lys Glu Ala Asp Pro Asn Lys Ile Tyr Arg Leu Leu Lys
325 330 335
Asn Tyr Lys Ser Lys Ser Met Leu Ala Tyr Leu Asn Tyr Asp Ile Asn
340 345 350
Asp Thr Ser Leu
355
<210> 5
<211> 353
<212> PRT
<213> African swine fever virus
<400> 5
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Ser Val Asp His Tyr His Ile Leu Lys Cys Cys Gly Leu Trp
20 25 30
Trp His Asn Gly Pro Ile Met Leu His Ile Arg Arg Asn Lys Leu Phe
35 40 45
Ile Arg Ser Thr Cys Phe Ser Gln Gly Ile Glu Leu Asn Ile Gly Leu
50 55 60
Met Lys Ala Val Lys Glu Asn Asn His Asp Leu Ile Lys Leu Phe Thr
65 70 75 80
Glu Trp Gly Ala Asp Ile Asn Tyr Gly Met Ile Cys Ala Leu Thr Glu
85 90 95
Asn Thr Arg Asp Leu Cys Lys Glu Leu Gly Ala Lys Glu Tyr Leu Glu
100 105 110
Arg Glu Tyr Ile Leu Lys Ile Phe Phe Asp Thr Thr Arg Asp Lys Thr
115 120 125
Ser Ser Asn Ile Ile Phe Cys His Glu Val Phe Ser Asn Asn Pro Asn
130 135 140
Leu Arg Ile Ile Asp Asn Leu Asp Leu Arg Gly Glu Ile Met Trp Glu
145 150 155 160
Leu Arg Gly Leu Met Glu Ile Thr Phe Met Leu Asp His Asp Asp Ser
165 170 175
Phe Ser Thr Val Leu Thr Lys Tyr Trp Tyr Ala Ile Ala Val Asp Tyr
180 185 190
Asp Leu Lys Asp Ala Ile Arg Tyr Phe Tyr Gln Lys Tyr Pro Arg Leu
195 200 205
His Arg Trp Arg Leu Met Cys Ala Leu Phe Tyr Asn Asn Val Phe Asp
210 215 220
Leu His Glu Leu Tyr Glu Ile Glu Arg Val Arg Met Asp Ile Asp Glu
225 230 235 240
Met Met His Ile Ala Cys Ile Gln Asp Tyr Ser Tyr Ser Ala Ile Tyr
245 250 255
Tyr Cys Phe Ile Met Gly Ala Asn Ile Asn Gln Ala Met Leu Val Ser
260 265 270
Ile Gln Asn Tyr Asn Leu Gly Asn Leu Phe Phe Cys Ile Asp Leu Gly
275 280 285
Ala Asn Ala Phe Glu Glu Gly Lys Ala Leu Ala Glu Gln Lys Glu Asn
290 295 300
Tyr Leu Ile Ala His Ala Leu Ser Leu Lys His Tyr Asn Pro Val Ile
305 310 315 320
Ser Leu Leu Ser Asn Val Met Asp Pro Glu Lys Ile Asn Tyr Met Leu
325 330 335
Lys Asn Tyr His Ser Ile Asn Met Gly Ile Phe Leu Asp Tyr Glu Gln
340 345 350
Arg
<210> 6
<211> 350
<212> PRT
<213> African swine fever virus
<400> 6
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Tyr Tyr Asp Leu Trp
20 25 30
Trp Tyr Asn Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ser Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Ser Leu Ile Lys Leu Phe Thr Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Arg Asp Leu Cys Gln Glu Leu Gly Ala Lys Glu Ile Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Leu Lys Leu Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Leu Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Val Arg Tyr Ser Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Met Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Met Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Thr Thr Ile Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Phe Ser Lys Asn Met Met Ile Phe Leu Ser Tyr Asp Leu Arg
340 345 350
<210> 7
<211> 353
<212> PRT
<213> African swine fever virus
<400> 7
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Cys Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Arg Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Arg Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Met Leu Glu Asn Lys Phe Val Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Val Cys
180 185 190
Lys Asn Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Lys Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Cys Ala Lys Asp Asn Asn Leu Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Val Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Thr Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Lys Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 8
<211> 357
<212> PRT
<213> African swine fever virus
<400> 8
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Val Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Tyr Leu Lys Arg Leu Cys Ala Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asn Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn Gln Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys His Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Ala Asp Phe Asp
275 280 285
Arg Ala Gln Leu Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Val Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Met Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 9
<211> 531
<212> PRT
<213> African swine fever virus
<400> 9
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Gly Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg Tyr
85 90 95
Asn Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Asp Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Ile Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys Tyr Thr Leu Glu Asp Asp Leu
145 150 155 160
Pro Leu Val His Leu Leu Ile Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Val Cys His Ile Ile
180 185 190
Asp Thr Phe Asp Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
His Leu Asp Ile Leu Ile Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Ile Asp Asn Leu Asp Val Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Val Ala Ile Lys Thr Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Ile Gln Lys Ile Ser Gln Tyr Val Ala Thr Phe Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Lys Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Asn Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Glu Arg Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Asn Lys Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Ala Arg Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Glu His Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asn Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 10
<211> 526
<212> PRT
<213> African swine fever virus
<400> 10
Met Phe Ser Leu Gln Asp Leu Cys Arg Lys His Leu Phe Ile Leu Pro
1 5 10 15
Asp Val Phe Gly Glu His Val Leu Gln Arg Leu Gly Leu Tyr Trp Arg
20 25 30
Cys His Gly Ser Leu Gln Arg Ile Gly Asp Asp His Ile Leu Ile Arg
35 40 45
Arg Asp Leu Ile Leu Ser Thr Asn Glu Ala Leu Arg Met Ala Gly Glu
50 55 60
Glu Gly Asn Asn Glu Val Val Lys Leu Leu Leu Leu Trp Lys Gly Asn
65 70 75 80
Leu His Tyr Ala Val Ile Gly Ala Leu Gln Gly Asp Gln Tyr Asp Leu
85 90 95
Ile His Lys Tyr Glu Asn Gln Ile Gly Asp Phe His Phe Ile Leu Pro
100 105 110
Leu Ile Gln Asp Ala Asn Thr Phe Glu Lys Cys His Ala Leu Glu Arg
115 120 125
Phe Cys Gly Val Ser Cys Leu Leu Lys His Ala Thr Lys Tyr Asn Met
130 135 140
Leu Pro Ile Leu Gln Lys Tyr Gln Glu Glu Leu Ser Met Arg Ala Tyr
145 150 155 160
Leu His Glu Thr Leu Phe Glu Leu Ala Cys Leu Trp Gln Arg Tyr Asp
165 170 175
Val Leu Lys Trp Ile Glu Gln Thr Met His Val Tyr Asp Leu Lys Ile
180 185 190
Met Phe Asn Ile Ala Ile Ser Lys Arg Asp Leu Thr Met Tyr Ser Leu
195 200 205
Gly Tyr Ile Phe Leu Phe Asp Arg Gly Asn Thr Glu Ala Thr Leu Leu
210 215 220
Thr Gln His Leu Glu Lys Thr Ala Ala Lys Gly Leu Leu His Phe Val
225 230 235 240
Leu Glu Thr Leu Lys Tyr Gly Gly Asn Ile Asp Thr Val Leu Thr Gln
245 250 255
Ala Val Lys Tyr Asn His Arg Lys Leu Leu Asp Tyr Phe Leu Arg Gln
260 265 270
Leu Pro Arg Lys His Ile Glu Lys Leu Leu Leu Leu Ala Val Gln Glu
275 280 285
Lys Ala Ser Lys Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Tyr
290 295 300
Ser Val Lys Arg Ile Lys Lys Leu Leu Arg Tyr Val Ile Glu Tyr Glu
305 310 315 320
Ser Thr Leu Val Ile Lys Ile Leu Leu Lys Lys Arg Val Asn Leu Ile
325 330 335
Asp Ala Met Leu Glu Lys Met Val Arg Tyr Phe Ser Ala Thr Lys Val
340 345 350
Arg Thr Ile Met Asp Glu Leu Ser Ile Ser Pro Glu Arg Val Ile Lys
355 360 365
Met Ala Ile Gln Lys Met Arg Thr Asp Ile Val Ile His Thr Ser Tyr
370 375 380
Val Trp Glu Asp Asp Leu Glu Arg Leu Thr Arg Leu Lys Asn Met Val
385 390 395 400
Tyr Thr Ile Lys Tyr Glu His Gly Lys Lys Met Leu Ile Lys Val Met
405 410 415
His Gly Ile Tyr Lys Asn Leu Leu Tyr Gly Glu Arg Glu Lys Val Met
420 425 430
Phe His Leu Ala Lys Leu Tyr Val Ala Gln Asn Ala Ala Thr Gln Phe
435 440 445
Arg Asp Ile Cys Lys Asp Cys Tyr Lys Leu Asp Val Ala Arg Phe Lys
450 455 460
Pro Arg Phe Lys Gln Leu Ile Leu Asp Cys Leu Glu Ile Val Thr Lys
465 470 475 480
Lys Ser Cys Tyr Ser Ile Leu Glu Ile Leu Glu Lys His Ile Ile Ser
485 490 495
Leu Phe Thr Met Lys Val Met Thr Glu Glu Glu Lys Asn Leu Cys Leu
500 505 510
Glu Ile Leu Tyr Lys Val Ile His Tyr Lys Thr Ile Gln Cys
515 520 525
<210> 11
<211> 254
<212> PRT
<213> African swine fever virus
<400> 11
Met Gln Asn Lys Ile Pro Asn Phe Asn Leu Phe Phe Phe Phe Leu Tyr
1 5 10 15
Arg Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Arg
20 25 30
Leu Arg Val Leu Thr Pro Gln Gln Arg Ala Val Ala Phe Phe Arg Ala
35 40 45
Asn Thr Lys Glu Leu Glu Asp Phe Leu Arg Ser Asp Gly Gln Ser Glu
50 55 60
Glu Ile Leu Ser Gly Pro Leu Leu Asn Arg Leu Leu Glu Pro Ser Cys
65 70 75 80
Pro Leu Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Gln Asn Pro Lys
85 90 95
Ala Gly Gln Leu Arg Gly Leu Glu Val Lys Met Leu Glu Arg Leu Tyr
100 105 110
Asp Ala Asn Ile Tyr Asn Ile Leu Ser Arg Leu Arg Pro Lys Lys Val
115 120 125
Arg Asn Lys Ala Ile Glu Leu Tyr Trp Val Phe Arg Ala Ile His Ile
130 135 140
Cys His Ala Pro Leu Val Leu Asp Ile Val Arg Tyr Glu Glu Pro Asp
145 150 155 160
Phe Ala Glu Leu Ala Phe Ile Cys Ala Ala Tyr Phe Gly Glu Pro Gln
165 170 175
Val Met Tyr Leu Leu Tyr Lys Tyr Met Pro Leu Thr Arg Ala Val Leu
180 185 190
Thr Asp Ala Ile Gln Ile Ser Leu Glu Ser Asn Asn Gln Val Gly Ile
195 200 205
Cys Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Leu Val Ser Ala
210 215 220
Pro Leu Arg Lys Arg Leu Arg Ala Lys Leu Arg Ser Gln Arg Lys Lys
225 230 235 240
Lys Asp Val Leu Ser Pro His Asp Phe Leu Leu Leu Leu Gln
245 250
<210> 12
<211> 237
<212> PRT
<213> African swine fever virus
<400> 12
Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Arg Leu
1 5 10 15
Arg Val Leu Thr Pro Gln Gln Arg Ala Val Ala Phe Phe Arg Ala Asn
20 25 30
Thr Lys Glu Leu Glu Asp Phe Leu Cys Ser Asp Gly Gln Ser Glu Glu
35 40 45
Ile Leu Ser Gly Pro Leu Leu Asn Arg Leu Leu Glu Pro Ser Gly Pro
50 55 60
Leu Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Gln Asn Pro Lys Ala
65 70 75 80
Gly Gln Val Arg Gly Leu Glu Val Lys Met Leu Glu Arg Leu Tyr Asp
85 90 95
Ala Asn Ile Tyr Asn Ile Leu Ser Arg Leu Arg Pro Glu Lys Val Arg
100 105 110
Asn Lys Ala Val Glu Leu Tyr Trp Val Phe Arg Ala Ile Asn Met Cys
115 120 125
His Ala Pro Leu Val Leu Asp Ile Val Arg Tyr Glu Glu Pro Asp Phe
130 135 140
Ala Glu Leu Ala Phe Ile Cys Ala Ala Tyr Phe Gly Glu Pro Gln Val
145 150 155 160
Met Tyr Leu Leu Tyr Lys Tyr Met Pro Leu Thr Arg Ala Val Leu Thr
165 170 175
Asp Ala Ile Gln Ile Ser Leu Glu Ser Asn Ser Gln Val Gly Ile Cys
180 185 190
Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Leu Val Arg Ala Pro
195 200 205
Leu Arg Lys Arg Leu Arg Ala Lys Leu Arg Ser Gln Arg Lys Lys Lys
210 215 220
Asp Val Leu Pro Pro His Asp Phe Leu Leu Leu Leu Gln
225 230 235
<210> 13
<211> 257
<212> PRT
<213> African swine fever virus
<400> 13
Met Gln Asn Lys Ile Pro Asn Phe Asn Leu Phe Phe Phe Phe Leu Tyr
1 5 10 15
Lys Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Lys
20 25 30
Leu Lys Asp Leu Thr Pro Pro Gln Arg Ala Val Ala Phe Phe Arg Ala
35 40 45
Asn Thr Lys Glu Leu Glu Asp Phe Leu Tyr Pro Asp Gly Gln Ser Glu
50 55 60
Glu Leu Leu Pro Gly Leu Leu Leu Asn Arg Leu Leu Glu Pro Ser Gly
65 70 75 80
Ser Ile Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Glu Asn Pro Lys
85 90 95
Ala Gly Arg Leu Arg Gly Leu Glu Val Lys Met Leu Glu Arg Leu Tyr
100 105 110
Asp Ala Asn Ile Tyr Asn Met Leu Ala Arg Leu Arg Pro Glu Leu Val
115 120 125
Arg Asp Lys Ala Ile Glu Leu Tyr Trp Leu Phe Arg Ala Ile Leu Met
130 135 140
Cys His Ser Pro Leu Val Leu Glu Ile Val Arg His Glu Thr Met Asp
145 150 155 160
Phe Ala Glu Thr Ala Phe Ile Cys Ala Ala Tyr Phe Ser Glu Pro Gln
165 170 175
Val Met Tyr Ala Leu Tyr Lys Phe Ile Pro Ile Ser Arg Ala Val Leu
180 185 190
Ala Asp Ala Ile Gln Met Cys Leu Glu Ser Asn Ser Glu Ala Gly Ile
195 200 205
Cys Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Lys Val Pro Gly
210 215 220
Ser Leu Arg Lys Arg Leu Arg Ala Ser Pro Leu Arg Gln Glu Arg Lys
225 230 235 240
Lys Lys Asn Val Leu Pro Pro His Glu Phe Leu Leu Met Leu His Gly
245 250 255
Ile
<210> 14
<211> 240
<212> PRT
<213> African swine fever virus
<400> 14
Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Lys Leu
1 5 10 15
Arg Asp Leu Thr Pro Met Gln Arg Ala Val Ala Phe Phe Arg Val Asn
20 25 30
Thr Lys Glu Leu Glu Asp Phe Leu Tyr Pro Asp Gly Gln Ser Glu Glu
35 40 45
Leu Leu Pro Gly Leu Leu Leu Asn Arg Leu Leu Glu Pro Ser Gly Pro
50 55 60
Ile Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Glu Asn Pro Lys Ala
65 70 75 80
Gly Arg Leu Arg Gly Leu Glu Val Lys Leu Leu Glu Arg Leu Tyr Asp
85 90 95
Ala Asn Ile Tyr Asn Met Leu Ala Gln Ile Arg Pro Glu Leu Val Arg
100 105 110
Ile Lys Ala Ile Glu Leu Tyr Trp Leu Phe Arg Ala Ile Leu Met Cys
115 120 125
His Ser Pro Leu Val Leu Glu Ile Val Arg His Glu Thr Met Asp Phe
130 135 140
Ala Glu Leu Ala Phe Ile Cys Ala Ala Tyr Phe Ser Glu Pro Gln Val
145 150 155 160
Met Tyr Ala Leu Tyr Lys Phe Ile Pro Ile Ser Arg Ala Val Leu Ala
165 170 175
Asp Ala Ile Glu Met Ser Leu Glu Ser Asn Ser Glu Thr Gly Ile Cys
180 185 190
Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Lys Val Pro Gly Pro
195 200 205
Leu Arg Lys Arg Leu Arg Ala Ser Pro Leu Arg Gln Glu Arg Lys Lys
210 215 220
Lys Asn Val Leu Pro Pro His Glu Phe Leu Leu Met Leu His Gly Ile
225 230 235 240
<210> 15
<211> 254
<212> PRT
<213> African swine fever virus
<400> 15
Met Gln Asn Lys Ile Pro Asn Phe Asn Leu Phe Phe Phe Phe Leu Tyr
1 5 10 15
Arg Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Arg
20 25 30
Leu Arg Val Leu Thr Pro Gln Gln Arg Ala Val Ala Phe Phe Arg Ala
35 40 45
Asn Thr Lys Glu Leu Glu Asp Phe Leu Cys Ser Asp Gly Gln Ser Glu
50 55 60
Glu Ile Leu Ser Gly Pro Leu Leu Asn Arg Leu Leu Glu Pro Ser Gly
65 70 75 80
Pro Leu Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Gln Asn Pro Lys
85 90 95
Ala Gly Gln Leu Arg Gly Leu Glu Val Lys Met Leu Glu Arg Leu Tyr
100 105 110
Asp Ala Asn Ile Tyr Asn Ile Leu Ser Arg Leu Arg Pro Glu Lys Val
115 120 125
Arg Asn Lys Ala Ile Glu Leu Tyr Trp Val Phe Arg Ala Ile His Ile
130 135 140
Cys His Ala Pro Leu Val Leu Asp Ile Val Arg Tyr Glu Glu Pro Asp
145 150 155 160
Phe Ala Glu Leu Ala Phe Ile Cys Ala Ala Tyr Phe Gly Glu Pro Gln
165 170 175
Val Met Tyr Leu Leu Tyr Lys Tyr Met Pro Leu Thr Arg Ala Val Leu
180 185 190
Thr Asp Ala Ile Arg Ile Ser Leu Glu Ser Asn Asn Gln Val Gly Ile
195 200 205
Cys Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Leu Val Ser Ala
210 215 220
Pro Leu Arg Lys Arg Leu Cys Ala Lys Leu Arg Ser Gln Arg Lys Lys
225 230 235 240
Lys Asp Val Leu Ser Pro His Asp Phe Leu Leu Leu Leu Gln
245 250
<210> 16
<211> 237
<212> PRT
<213> African swine fever virus
<400> 16
Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Arg Leu
1 5 10 15
Arg Val Leu Thr Pro Gln Gln Arg Ala Val Ala Phe Phe Arg Ala Asn
20 25 30
Thr Lys Glu Val Glu Asp Phe Leu Cys Ser Asp Gly Gln Ser Glu Glu
35 40 45
Val Leu Ser Gly Pro Leu Leu Asn Arg Leu Leu Glu Pro Ser Gly Pro
50 55 60
Leu Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Gln Asn Pro Lys Ala
65 70 75 80
Gly Gln Val Arg Gly Leu Glu Val Lys Met Leu Glu Arg Leu Tyr Asp
85 90 95
Ala Asn Ile Tyr Asn Ile Leu Ser Arg Leu Arg Pro Glu Lys Val Arg
100 105 110
Asn Lys Ala Val Glu Leu Tyr Trp Val Phe Arg Ala Ile Asn Met Cys
115 120 125
His Ala Pro Leu Val Leu Asp Ile Val Arg Tyr Glu Glu Pro Asp Phe
130 135 140
Ala Glu Leu Ala Phe Ile Cys Ala Ala Tyr Phe Gly Glu Pro Gln Val
145 150 155 160
Met Tyr Leu Leu Tyr Lys Tyr Met Pro Leu Ser Arg Ala Val Leu Thr
165 170 175
Asp Ala Ile Gln Ile Ser Leu Glu Ser Asn Ser Gln Val Gly Ile Cys
180 185 190
Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Leu Val Arg Ala Pro
195 200 205
Leu Arg Lys Arg Leu Arg Ala Lys Leu Arg Ser Gln Arg Lys Lys Lys
210 215 220
Asp Val Leu Pro Pro His Asp Phe Leu Leu Leu Leu Gln
225 230 235
<210> 17
<211> 237
<212> PRT
<213> African swine fever virus
<400> 17
Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Arg Leu
1 5 10 15
Arg Val Leu Thr Pro Gln Gln Arg Ala Val Ala Phe Phe Arg Ala Asn
20 25 30
Thr Lys Glu Leu Glu Asp Phe Leu Cys Pro Asp Gly Gln Ser Glu Glu
35 40 45
Val Leu Ser Gly Ser Leu Leu Asn Arg Leu Leu Glu Pro Ser Gly Pro
50 55 60
Leu Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Gln Asn Pro Lys Ala
65 70 75 80
Gly Gln Leu Arg Gly Leu Glu Val Lys Met Leu Glu Arg Leu Tyr Asp
85 90 95
Ala Asn Ile Tyr Asn Ile Leu Ser Arg Leu Arg Pro Glu Lys Val Arg
100 105 110
Asn Lys Ala Val Glu Leu Tyr Trp Val Phe Arg Ala Ile Asn Met Cys
115 120 125
His Ala Pro Leu Val Leu Asp Ile Val Arg Asn Glu Glu Leu Asp Phe
130 135 140
Ala Glu Leu Ala Phe Ile Cys Ala Ala Tyr Phe Gly Glu Pro Gln Val
145 150 155 160
Met Tyr Leu Leu Tyr Lys Tyr Met Pro Leu Thr Arg Ala Val Leu Thr
165 170 175
Asp Ala Ile Gln Ile Ser Leu Glu Ser Asn Ser Gln Val Gly Ile Cys
180 185 190
Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Leu Val Arg Ala Pro
195 200 205
Leu Arg Lys Arg Leu Arg Ala Lys Leu Arg Ser Gln Arg Lys Lys Lys
210 215 220
Asp Val Leu Pro Pro His Asp Phe Leu Leu Leu Leu Gln
225 230 235
<210> 18
<211> 254
<212> PRT
<213> African swine fever virus
<400> 18
Met Gln Asn Lys Ile Pro Asn Phe Asn Leu Phe Phe Phe Phe Leu Tyr
1 5 10 15
Arg Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Arg
20 25 30
Leu Arg Val Leu Thr Pro Gln Gln Arg Ala Val Ala Phe Phe Arg Ala
35 40 45
Asn Thr Lys Glu Leu Glu Asp Phe Leu Cys Ser Asp Gly Gln Ser Glu
50 55 60
Glu Ile Leu Ser Gly Pro Leu Leu Asn Arg Leu Leu Glu Pro Ser Gly
65 70 75 80
Pro Leu Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Gln Asn Pro Lys
85 90 95
Ala Gly Gln Leu Arg Gly Leu Glu Val Lys Met Leu Glu Arg Leu Tyr
100 105 110
Asp Ala Asn Ile Tyr Asn Ile Leu Ser Arg Leu Arg Pro Glu Lys Val
115 120 125
Arg Asn Lys Ala Ile Glu Leu Tyr Trp Val Phe Arg Ala Ile His Ile
130 135 140
Cys His Ala Pro Leu Val Leu Asp Ile Val Arg Tyr Glu Glu Pro Asp
145 150 155 160
Phe Ala Glu Leu Ala Phe Ile Cys Ala Ala Tyr Phe Gly Glu Pro Gln
165 170 175
Val Met Tyr Leu Leu Tyr Lys Tyr Met Pro Leu Thr Arg Ala Val Leu
180 185 190
Thr Asp Ala Ile Arg Ile Ser Leu Glu Ser Asn Asn Gln Val Gly Ile
195 200 205
Cys Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Leu Val Ser Ala
210 215 220
Pro Leu Arg Lys Arg Leu Arg Ala Lys Leu Arg Ser Gln Arg Lys Lys
225 230 235 240
Lys Asp Val Leu Ser Pro His Asp Phe Leu Leu Leu Leu Gln
245 250
<210> 19
<211> 72
<212> PRT
<213> African swine fever virus
<400> 19
Met Gln Asn Lys Ile Pro Asn Phe Asn Leu Phe Phe Phe Phe Leu Tyr
1 5 10 15
Arg Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Arg
20 25 30
Leu Arg Val Leu Thr Pro Gln Gln Arg Ala Val Ala Phe Phe Arg Ala
35 40 45
Asn Thr Lys Glu Leu Glu Asp Phe Leu Arg Ser Asp Gly Gln Ser Glu
50 55 60
Glu Ile Leu Ser Gly Pro Pro Pro
65 70
<210> 20
<211> 153
<212> PRT
<213> African swine fever virus
<400> 20
Met Tyr Phe Lys Lys Lys Tyr Ile Gly Leu Ile Asp Lys Asn Cys Glu
1 5 10 15
Lys Lys Ile Leu Asp Asp Ser Ser Thr Ile Lys Ile Cys Tyr Ile Leu
20 25 30
Ile Gly Ile Leu Ile Gly Thr Asn Met Ile Thr Leu Ile Tyr Asn Phe
35 40 45
Ile Phe Trp Asp Asn Tyr Ile Lys Cys Tyr Arg Asn Asn Asp Lys Met
50 55 60
Phe Tyr Cys Pro Asn Asp Trp Val Gly Tyr Asn Asn Ile Cys Tyr Tyr
65 70 75 80
Phe Ser Asn Gly Ser Phe Ser Lys Asn Tyr Thr Ala Ala Ser Asn Phe
85 90 95
Cys Arg Gln Leu Asn Gly Thr Leu Ala Asn Asn Asp Thr Asn Leu Leu
100 105 110
Asn Leu Thr Lys Ile Tyr Asn Asn Gln Ser Met Tyr Trp Val Asn Asn
115 120 125
Thr Val Ile Leu Arg Gly Asp Asn Lys Tyr Ser Gln Lys Val Asn Tyr
130 135 140
Thr Asp Leu Leu Phe Ile Cys Gly Lys
145 150
<210> 21
<211> 402
<212> PRT
<213> African swine fever virus
<400> 21
Met Ile Ile Ile Val Ile Phe Leu Met Cys Leu Lys Ile Val Leu Asn
1 5 10 15
Asn Ile Ile Ile Trp Ser Thr Leu Asn Gln Thr Val Phe Leu Asn Asn
20 25 30
Ile Phe Thr Ile Asn Asp Thr Tyr Gly Gly Leu Phe Trp Asn Thr Tyr
35 40 45
Tyr Asp Asn Asn Arg Ser Asn Phe Thr Tyr Cys Gly Ile Ala Gly Asn
50 55 60
Tyr Cys Ser Cys Cys Gly His Asn Ile Ser Leu Tyr Asn Thr Thr Asn
65 70 75 80
Asn Cys Ser Leu Ile Ile Phe Pro Asn Asn Thr Glu Ile Phe Asn Arg
85 90 95
Thr Tyr Glu Leu Val Tyr Leu Asp Lys Lys Ile Asn Tyr Thr Val Lys
100 105 110
Leu Leu Lys Ser Val Asp Ser Pro Thr Ile Thr Tyr Asn Cys Thr Asn
115 120 125
Ser Leu Ile Thr Cys Lys Asn Asn Asn Gly Thr Asn Val Asn Ile Tyr
130 135 140
Leu Ile Ile Asn Asn Thr Ile Val Asn Asp Thr Asn Gly Asp Ile Leu
145 150 155 160
Asn Tyr Tyr Trp Asn Gly Asn Asn Asn Phe Thr Ala Thr Cys Met Ile
165 170 175
Asn Asn Thr Ile Ser Ser Leu Asn Glu Thr Glu Asn Ile Asn Cys Thr
180 185 190
Asn Pro Ile Leu Lys Tyr Gln Asn Tyr Leu Ser Thr Leu Phe Tyr Ile
195 200 205
Ile Ile Phe Ile Val Ser Gly Leu Ile Ile Gly Ile Phe Ile Ser Ile
210 215 220
Ile Ser Val Leu Ser Ile Arg Arg Lys Arg Lys Lys His Val Glu Glu
225 230 235 240
Ile Glu Ser Pro Pro Pro Ser Glu Ser Asn Glu Glu Asp Ile Ser His
245 250 255
Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu Pro Leu Leu
260 265 270
Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile Tyr Tyr Met
275 280 285
Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe Pro Leu Pro Lys Pro Cys
290 295 300
Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
305 310 315 320
Pro Cys Pro Pro Pro Lys Pro Cys Ser Pro Pro Lys Pro Cys Arg Pro
325 330 335
Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys
340 345 350
Pro Pro Pro Lys Pro Cys Pro Pro Ser Lys Pro Cys Pro Ser Pro Glu
355 360 365
Ser Tyr Ser Pro Pro Lys Pro Leu Pro Ser Ile Pro Leu Leu Pro Asn
370 375 380
Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser Leu Ile His Val Asp Arg
385 390 395 400
Ile Ile
<210> 22
<211> 392
<212> PRT
<213> African swine fever virus
<400> 22
Met Ile Ile Ile Leu Ile Phe Leu Ile Cys Leu Lys Ile Val Leu Asn
1 5 10 15
Asn Asn Ile Ile Ile Trp His Thr Leu Asn Glu Thr Ile Phe Leu Asn
20 25 30
Asn Ser Ile Thr Phe Thr Asp Asn Leu Gly Gly Leu Phe Trp Asn Thr
35 40 45
Tyr Tyr Asn Asn Asn His Ser Ile Leu Thr Ser Cys Gly Ile Tyr Gln
50 55 60
Asn Tyr Cys Ser Cys Thr Asn Asn Tyr Ser Thr Ser Leu Tyr Asn Ile
65 70 75 80
Thr Asn Asn Cys Gly Leu Ile Ile Phe Pro Asn Asn Thr Lys Arg Phe
85 90 95
Asn Thr Thr Tyr Glu Leu Val Tyr Leu Asn Asn Ser Thr Lys Tyr Thr
100 105 110
Ile Asn Leu Leu Val Pro Val Thr Pro Pro Asn Ile Thr Tyr Asn Cys
115 120 125
Thr Thr Ser Val Ile Thr Cys Lys Lys Asn Asp Gly Thr Asn Thr Asn
130 135 140
Met Phe Leu Lys Ile Asn Asp Thr Ile Val Lys Ser Ser Asn Glu Ser
145 150 155 160
Val Phe Glu Tyr Ser Trp Asn Ser Thr Asp Leu Asn Asn Asn Phe Thr
165 170 175
Ala Ile Cys Ile Ile Asn Asn Thr Ile Asn Ser Ser Asn Asp Thr Gln
180 185 190
Thr Ile Glu Cys Pro Asn Ile Leu Leu Asn Asn Tyr Leu Asp Phe Phe
195 200 205
Gln Val Thr Ser Tyr Met Phe Tyr Met Ile Ile Phe Ile Val Thr Gly
210 215 220
Ile Ile Ala Ser Ile Phe Ile Ser Ile Ile Thr Phe Leu Ser Leu Arg
225 230 235 240
Lys Arg Lys Lys His Val Glu Glu Ile Glu Ser Pro Pro Pro Ser Glu
245 250 255
Ser Asn Glu Glu Asp Ile Ser His Asp Asp Thr Thr Ser Ile His Glu
260 265 270
Pro Ser Pro Arg Glu Pro Leu Leu Pro Lys Pro Tyr Ser Arg Tyr Gln
275 280 285
Tyr Asn Thr Pro Ile Tyr Tyr Met Arg Pro Ser Thr Gln Pro Leu Asn
290 295 300
Pro Phe Pro Leu Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro
305 310 315 320
Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys
325 330 335
Arg Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
340 345 350
Pro Cys Pro Ser Pro Glu Thr Tyr Ser Pro Pro Lys Pro Leu Pro Asn
355 360 365
Ile Pro Leu Leu Pro Asn Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser
370 375 380
Leu Ile His Val Asp Arg Ile Ile
385 390
<210> 23
<211> 389
<212> PRT
<213> African swine fever virus
<400> 23
Met Ile Ile Ile Leu Ile Phe Leu Ile Tyr Leu Lys Leu Val Leu Asn
1 5 10 15
Asn Asn Ile Ile Ile Trp His Pro Thr Leu Asn Glu Thr Ile Phe Leu
20 25 30
Asn Val Thr Thr Ile Gly Asn Ile Ser Gly Leu Phe Trp Asn Thr Tyr
35 40 45
Tyr Asn Asn Asn Arg Ser Glu Leu Thr Lys Cys Gly Ile Tyr Asn Asn
50 55 60
Tyr Cys Ser Cys Asp Ser Leu Asn Thr Ser Leu Tyr Asn Ile Asn Asn
65 70 75 80
Cys Ser Leu Val Ile Phe Pro Asn Asn Thr Lys Ile Phe Asn Thr Ile
85 90 95
Tyr Glu Leu Ile Tyr Ser Gly Asn Gln Thr Asn Tyr Thr Ile Lys Leu
100 105 110
Leu Glu Ser Thr Thr Pro Pro Asn Ile Thr Tyr Asn Cys Thr Thr Ser
115 120 125
Val Ile Thr Cys Lys Lys Asn Asn Gly Thr Asn Thr Asn Ile Phe Leu
130 135 140
Thr Ile Asn Asn Thr Ile Val Asn Ser Thr Asn Glu Asp Val Ile Tyr
145 150 155 160
Tyr Tyr Trp Asn Arg Ser Glu Phe Asn Asn Phe Thr Ala Thr Cys Met
165 170 175
Ile Asn Asn Thr Ile Asn Ser Ser Asn Ile Ser Glu Ile Ile Asp Cys
180 185 190
Thr Asn Thr Leu Leu Leu Asn Ser Tyr Leu Asp Phe Phe Gln Val Ala
195 200 205
Gly Tyr Met Phe Tyr Met Ile Ile Phe Ile Val Thr Gly Ile Thr Val
210 215 220
Ser Ile Phe Ile Ser Ile Ile Thr Phe Leu Ser Leu Arg Lys Arg Lys
225 230 235 240
Lys His Val Glu Glu Ile Glu Ser Leu Pro Pro Glu Ser Asn Glu Glu
245 250 255
Glu Cys Gln His Asp Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro
260 265 270
Arg Glu Pro Leu Leu Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr
275 280 285
Pro Ile Tyr Tyr Met Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe Pro
290 295 300
Leu Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro
305 310 315 320
Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro
325 330 335
Lys Pro Cys Pro Pro Pro Glu Ser Cys Ser Ser Pro Glu Ser Cys Ser
340 345 350
Ser Pro Glu Ser Tyr Ser Pro Pro Lys Pro Leu Pro Ser Ile Pro Leu
355 360 365
Leu Pro Asn Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser Leu Ile His
370 375 380
Val Asp Arg Ile Ile
385
<210> 24
<211> 360
<212> PRT
<213> African swine fever virus
<400> 24
Met Ile Ile Leu Ile Phe Leu Ile Phe Ser Asn Ile Val Leu Ser Ile
1 5 10 15
Asp Tyr Trp Val Ser Phe Asn Lys Thr Ile Ile Leu Asp Ser Asn Ile
20 25 30
Thr Asn Asp Asn Asn Asp Ile Asn Gly Val Ser Trp Asn Phe Phe Asn
35 40 45
Asn Ser Phe Asn Thr Leu Ala Thr Cys Gly Lys Ala Gly Asn Phe Cys
50 55 60
Glu Cys Ser Asn Tyr Ser Thr Ser Ile Tyr Asn Ile Thr Asn Asn Cys
65 70 75 80
Ser Leu Thr Ile Phe Pro His Asn Asp Val Phe Asp Thr Thr Tyr Gln
85 90 95
Val Val Trp Asn Gln Ile Ile Asn Tyr Thr Ile Lys Leu Leu Thr Pro
100 105 110
Ala Thr Pro Pro Asn Ile Thr Tyr Asn Cys Thr Asn Phe Leu Ile Thr
115 120 125
Cys Lys Lys Asn Asn Gly Thr Asn Thr Asn Ile Tyr Leu Asn Ile Asn
130 135 140
Asp Thr Phe Val Lys Tyr Thr Asn Glu Ser Ile Leu Glu Tyr Asn Trp
145 150 155 160
Asn Asn Ser Asn Ile Asn Asn Phe Thr Ala Thr Cys Ile Ile Asn Asn
165 170 175
Thr Ile Ser Thr Ser Asn Glu Thr Thr Leu Ile Asn Cys Thr Tyr Leu
180 185 190
Thr Leu Ser Ser Asn Tyr Phe Tyr Thr Phe Phe Lys Leu Tyr Tyr Ile
195 200 205
Pro Leu Ser Ile Ile Ile Gly Ile Thr Ile Ser Ile Leu Leu Ile Ser
210 215 220
Ile Ile Thr Phe Leu Ser Leu Arg Lys Arg Lys Lys His Val Glu Glu
225 230 235 240
Ile Glu Ser Pro Pro Pro Glu Ser Asn Glu Glu Glu Gln Cys Gln His
245 250 255
Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu Pro Leu Leu
260 265 270
Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile Tyr Tyr Met
275 280 285
Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe Pro Leu Pro Lys Pro Cys
290 295 300
Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
305 310 315 320
Pro Cys Pro Ser Ala Glu Ser Tyr Ser Pro Pro Lys Pro Leu Pro Ser
325 330 335
Ile Pro Leu Leu Pro Asn Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser
340 345 350
Leu Ile His Val Asp Arg Ile Ile
355 360
<210> 25
<211> 375
<212> PRT
<213> African swine fever virus
<400> 25
Met Ile Ile Ile Leu Ile Phe Leu Ile Ile Pro Asn Ile Val Leu Ser
1 5 10 15
Ile Asp Tyr Trp Val Ser Phe Asn Lys Thr Ile Ile Leu Asp Ser Asn
20 25 30
Ile Thr Asn Asp Asn Asn Asp Ile Asn Gly Val Ser Trp Asn Phe Leu
35 40 45
Asn Asn Ser Leu Asn Thr Leu Ala Thr Cys Gly Lys Ala Gly Asn Phe
50 55 60
Cys Glu Cys Ser Asn Tyr Ser Thr Ser Leu Tyr Asn Ile Ala His Asn
65 70 75 80
Cys Ser Leu Thr Ile Phe Pro His Asn Asp Val Phe Gly Thr Pro Tyr
85 90 95
Gln Val Val Trp Asn Gln Ile Ile Asn Tyr Thr Ile Lys Leu Leu Thr
100 105 110
Pro Val Thr Pro Pro Asn Ile Thr Tyr Asn Cys Thr Asn Phe Leu Ile
115 120 125
Thr Cys Lys Lys Asn Asn Gly Thr Asn Thr Ile Ile Tyr Phe Asn Ile
130 135 140
Asn Asp Thr Asn Val Lys Tyr Thr Asn Glu Ser Ile Leu Glu Tyr Asn
145 150 155 160
Trp Asn Asn Ser Asn Phe Asn Asn Phe Thr Ala Thr Cys Ile Ile Asn
165 170 175
Asn Thr Ile Asn Ser Ser Asn Asp Thr Gln Thr Ile Asp Cys Ile Asn
180 185 190
Thr Leu Leu Ser Ser Tyr Leu Asp Phe Phe Gln Val Ala Ser Tyr Met
195 200 205
Phe Tyr Met Ile Ile Phe Ile Ala Thr Gly Ile Ile Ala Ser Ile Phe
210 215 220
Ile Ser Ile Ile Thr Phe Leu Ser Leu Arg Lys Arg Lys Lys His Val
225 230 235 240
Glu Glu Ile Glu Ser Pro Ser Pro Ser Glu Ser Asn Glu Glu Glu Gln
245 250 255
Cys Gln His Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu
260 265 270
Pro Leu Leu Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile
275 280 285
Tyr Tyr Met Arg Pro Leu Thr Gln Pro Leu Asn Pro Ser Pro Leu Pro
290 295 300
Lys Leu Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro
305 310 315 320
Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Ser Ser Glu Ser
325 330 335
Cys Ser Pro Pro Glu Ser Tyr Ser Leu Pro Lys Pro Leu Pro Asn Ile
340 345 350
Pro Leu Leu Pro Asn Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser Leu
355 360 365
Ile His Val Asp Arg Ile Ile
370 375
<210> 26
<211> 392
<212> PRT
<213> African swine fever virus
<400> 26
Met Ile Ile Lys Leu Ile Phe Leu Ile Cys Phe Lys Ile Val Leu Ser
1 5 10 15
Ile Asp Asn Lys Thr Lys Phe Asn Glu Thr Leu Ile Leu Asp Asn Ile
20 25 30
Asp Tyr Trp Val Lys Phe Asn Asp Thr Ile Thr Leu Asp Ser Asn Ile
35 40 45
Thr Ser Glu Ile Glu Ala Val Ser Trp Asn Phe Tyr Asn Asn Thr Phe
50 55 60
Asn Leu Leu Ala Ile Cys Gly Lys Ala Ser Asn Phe Cys Ser Cys Ser
65 70 75 80
Asn Tyr Ser Thr Ser Phe Phe Asn Ile Thr Asn Asn Cys Ser Leu Thr
85 90 95
Ile Phe Leu Ile Asp Glu Thr Leu Phe Asn Thr Thr Tyr Gln Ile Val
100 105 110
Tyr Ser Thr Asn Ile Ile Asn Tyr Lys Ile Asn Leu Leu Ile Pro Val
115 120 125
Thr Pro Pro Ile Ile Ser Tyr Asn Cys Ala Asn Cys Ser Ile Asn Cys
130 135 140
Lys Lys Ser Asn Gly Thr Asn Thr Asn Ile Phe Leu Ser Ile Asn Asp
145 150 155 160
Thr Ile Val Thr Tyr Thr Asn Glu Ser Ile Leu Asn Tyr Asp Tyr Asn
165 170 175
Cys Ser Ile Leu Asn Asn Asn Phe Thr Val Thr Cys Ile Ile Asn Asn
180 185 190
Thr Ile Ser Thr Ser Asn Thr Thr Glu Phe Ile Asn Cys Thr Asn Ile
195 200 205
Leu Leu Ser Ser Tyr Leu Asp Phe Phe Gln Val Thr Ser Tyr Ile Phe
210 215 220
Tyr Met Ile Ile Phe Ile Val Thr Gly Ile Thr Val Ser Ile Leu Ile
225 230 235 240
Ser Ile Ile Thr Phe Leu Phe Ile Arg Lys Arg Lys His Val Glu Glu
245 250 255
Ile Glu Ser Pro Pro Pro Glu Ser Asn Glu Glu Glu Gln Gln Cys His
260 265 270
His Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu Pro Leu Leu
275 280 285
Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile Tyr Tyr Met
290 295 300
Arg Pro Ser Thr Gln Gln Leu Phe Lys Ser Tyr Ser Leu Pro Lys Pro
305 310 315 320
Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro
325 330 335
Lys Pro Cys Pro Pro Ser Lys Pro Cys Pro Pro Pro Glu Pro Tyr Ser
340 345 350
Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Tyr Pro Ser Leu Pro Ser
355 360 365
Ile Pro Leu Pro Pro Asp Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser
370 375 380
Leu Ile His Val Asp Arg Ile Ile
385 390
<210> 27
<211> 385
<212> PRT
<213> African swine fever virus
<400> 27
Met Ile Ile Lys Leu Ile Phe Leu Ile Ser Phe Lys Met Ile Leu Gly
1 5 10 15
Ile Asp Tyr Trp Val Ser Leu Asn Asn Thr Ile Ile Leu Asp Ser Asn
20 25 30
Ile Thr Ile Asn Asn Ile Thr Asn Thr Thr Asn Asn Pro Thr Leu Asn
35 40 45
Gly Ile Phe Trp Asn Ile Tyr Asn Asn Ser Tyr Asn Asn Thr Phe Asn
50 55 60
Leu Leu Thr Thr Cys Gly Asn Thr Tyr Asn Ile Cys Ser Cys Ser Asn
65 70 75 80
Asn Tyr Asn Thr Ile Leu Phe Asn Tyr Asn Thr Thr Asn Asn Cys Ser
85 90 95
Leu Ile Ile Ser Pro His Asp Glu Lys Ile Phe Asp Thr Met Phe Gln
100 105 110
Ile Ile Tyr Leu Thr Asn Lys Ile Asn Tyr Thr Ile Arg Trp Leu Gln
115 120 125
Pro Val Asp Pro Pro Asn Ile Ser Phe Asn Asp Ser Asn Ser Leu Ile
130 135 140
Lys Cys Glu Lys Asn Asn Gly Thr Asn Thr Glu Ile Tyr Leu Tyr Leu
145 150 155 160
Asn Asp Thr Phe Ile Asn Asn Thr Asn Glu Asn Asp Leu Lys Tyr Tyr
165 170 175
Trp Asn Cys Ser Glu Leu Asn Tyr Asn Ile Thr Ala Thr Cys Ile Ile
180 185 190
Asn Asn Thr Leu Asn Ser Ala Asn Thr Thr Lys Val Ile Asn Cys Thr
195 200 205
Asn Leu Leu Leu Lys Ser Asp Gln Asn Tyr Phe Leu Lys Asn Ile His
210 215 220
Thr Leu Phe Tyr Ile Ile Ile Phe Ile Val Thr Gly Ile Ile Ile Ser
225 230 235 240
Ile Phe Ile Ala Ile Ile Thr Phe Leu Ser Leu Arg Lys Arg Lys Lys
245 250 255
His Val Glu Glu Ile Glu Ser Pro Ser Pro Glu Ser Asn Glu Glu Glu
260 265 270
Glu Gln Gln His His His Asp Thr Thr Ser Ile His Glu Pro Ser Pro
275 280 285
Arg Glu Pro Leu Leu Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr
290 295 300
Pro Ile Tyr Tyr Met Arg Pro Ser Thr Gln Gln Leu Phe Lys Ser Tyr
305 310 315 320
Ser Leu Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
325 330 335
Pro Cys Pro Pro Pro Lys Pro Cys Pro Ser Pro Glu Ser Tyr Pro Ser
340 345 350
Pro Glu Pro Tyr Pro Leu Leu Pro Asn Ile Pro Leu Pro Pro Asn Ile
355 360 365
Pro Pro Leu Ser Thr Gln Asn Ile Ser Leu Ile His Val Asp Arg Ile
370 375 380
Ile
385
<210> 28
<211> 382
<212> PRT
<213> African swine fever virus
<400> 28
Met Ile Ile Lys Val Ile Phe Leu Val Phe Phe Lys Met Val Leu Ser
1 5 10 15
Asn Ile Ile Ile Trp Ser Thr Leu Asn Asn Thr Ile Tyr Leu Asn Ile
20 25 30
Asn Tyr Ser Asp Ser Asn Leu Tyr Thr Gly Leu Phe Trp Asn Lys Tyr
35 40 45
Tyr Asn Asn Thr Arg Asn Asn Phe Thr Thr Cys Val Thr Ser Asn Ser
50 55 60
Ser Tyr Cys Thr Cys Lys Gly His Asn Thr Ser Leu Tyr Asn Ile Thr
65 70 75 80
Asn Asn Cys Ser Leu Ile Ile Phe Pro Asn Asn Thr Lys Ile Phe Asn
85 90 95
Thr Thr Tyr Glu Leu Val Tyr Leu Asn Asn Lys Ile Asn Tyr Thr Ile
100 105 110
Gln Met Val Gln Pro Val Asp Pro Pro Ile Ile Ile Tyr Asn Asp Thr
115 120 125
Asn Asn Ser Leu Ile Thr Cys Glu Lys Asn Asn Gly Thr Asn Thr Glu
130 135 140
Ile Tyr Leu Tyr Leu Asn Asp Thr Phe Ile Asn Asn Thr Asn Glu Asn
145 150 155 160
Ser Ile Lys Tyr Tyr Trp Asn Cys Ser Glu Leu Asn His Asn Ile Thr
165 170 175
Thr Thr Cys Ile Ile Asn Asn Thr Leu Asn Ser Ala Asn Thr Thr Lys
180 185 190
Val Ile Asn Cys Thr Asn Leu Leu Leu Lys Ser Asp Gln Asn Tyr Phe
195 200 205
Leu Lys Asn Ile His Thr Leu Phe Tyr Ile Ile Ile Phe Ile Val Gly
210 215 220
Gly Thr Leu Ile Ser Ile Ile Ile Ser Ile Ile Thr Phe Leu Ser Leu
225 230 235 240
Arg Lys Arg Lys Lys His Val Glu Glu Ile Glu Ser Pro Pro Pro Ser
245 250 255
Glu Ser Asn Glu Glu Glu His Cys Gln His Asp Asp Thr Thr Ser Ile
260 265 270
His Glu Pro Ser Pro Arg Glu Pro Leu Leu Pro Lys Pro Tyr Ser Arg
275 280 285
Tyr Gln Tyr Asn Thr Pro Ile Tyr Tyr Met Arg Pro Ser Thr Gln Pro
290 295 300
Leu Asn Pro Phe Pro Leu Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys
305 310 315 320
Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
325 330 335
Pro Cys Pro Pro Pro Lys Pro Cys Pro Ser Pro Glu Ser His Ser Pro
340 345 350
Pro Lys Pro Leu Pro Ser Ile Pro Leu Leu Pro Asn Ile Pro Pro Leu
355 360 365
Ser Thr Gln Asn Ile Ser Leu Ile His Val Asp Arg Ile Ile
370 375 380
<210> 29
<211> 404
<212> PRT
<213> African swine fever virus
<400> 29
Met Phe Ile Thr Leu Ile Phe Leu Ser Tyr Ile Asn Ile Val Leu Ser
1 5 10 15
Asn Asn Tyr Trp Ala Arg Leu Asn Glu Thr Ile Thr Leu Asn Ser Asn
20 25 30
Ile Thr Asn Asp Thr Asn Asn Glu Leu Gly Ile Phe Trp Asn Ser Tyr
35 40 45
Asn Asn Thr Tyr Tyr Asn Asn Thr Phe Asn Asn Ile Ala Ile Cys Gly
50 55 60
Lys Lys Gly Ile Phe Cys Glu Cys Asn Ile Asn Tyr Asn Thr Ser Ile
65 70 75 80
Ser Asn Thr Ser Ile Ser Asn Thr Ser Ile Tyr Asn Val Thr Asn Asn
85 90 95
Cys Ser Leu Thr Ile Phe Leu Tyr Asp Asp Asn Ile Phe Lys Thr Tyr
100 105 110
Gln Leu Val Tyr Gln Asn Tyr Lys Ile Asn Tyr Thr Ile Asn Leu Leu
115 120 125
Leu Pro Val Thr Ser Pro Asn Ile Thr Tyr Asn Cys Thr Asn Ser Leu
130 135 140
Ile Thr Cys Glu Lys Asn Asp Gly Thr Asn Thr Asn Met Phe Leu Ser
145 150 155 160
Ile Asn Asn Ile Thr Ile Asn His Thr Asn Gln Asp Ile Leu Thr Tyr
165 170 175
Tyr Trp Asn Asn Ser Glu Phe Asn Asn Phe Thr Ala Thr Cys Met Ile
180 185 190
Asn Asn Thr Leu Asn Ser Ala Asn Thr Thr Lys Val Ile Asn Cys Thr
195 200 205
Asn Pro Leu Leu Asn Ser Tyr Gln Asn Tyr Phe Leu Glu Asn Ile His
210 215 220
Thr Leu Phe Tyr Ile Ile Ile Phe Ile Val Ser Gly Leu Ile Ala Ser
225 230 235 240
Ile Phe Ile Ser Ile Ile Thr Phe Leu Ser Leu Arg Lys Arg Lys Lys
245 250 255
His Val Glu Glu Ile Glu Ser Pro Pro Pro Glu Ser Asn Glu Glu Glu
260 265 270
Gln Cys Gln His Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg
275 280 285
Glu Pro Leu Leu Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro
290 295 300
Ile Tyr Tyr Met Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe Pro Leu
305 310 315 320
Pro Asn Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys
325 330 335
Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
340 345 350
Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Ser Ser
355 360 365
Pro Glu Ser Tyr Ser Pro Pro Lys Pro Leu Pro Ser Ile Pro Leu Leu
370 375 380
Pro Asn Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser Leu Ile His Val
385 390 395 400
Asp Arg Ile Ile
<210> 30
<211> 381
<212> PRT
<213> African swine fever virus
<400> 30
Met Ile Ile Lys Leu Ile Phe Leu Ile Cys Phe Lys Ile Val Leu Ser
1 5 10 15
Ile Asn Tyr Trp Val Arg Tyr Asn Asp Thr Val Thr Leu Asn Ser Asn
20 25 30
Ile Asn Ser Glu Thr Glu Gly Ile Phe Trp Asn Phe Tyr Asn Asn Thr
35 40 45
Phe Asn Thr Ile Ala Thr Cys Gly Lys Lys Asn Asn Val Cys Glu Cys
50 55 60
Ser Asn Tyr Asp Lys Ser Leu Tyr Asn Ile Thr Asn Asn Cys Ser Leu
65 70 75 80
Thr Ile Phe Pro Asn Asn Thr Lys Ile Phe Asn Thr Thr Tyr Gln Leu
85 90 95
Val Tyr Ser Arg Asn Arg Ile Asn Tyr Thr Ile Asn Leu Leu Leu Pro
100 105 110
Val Thr Ser Pro Ile Ile Thr Tyr Asn Cys Thr Gln Ser Leu Ile Thr
115 120 125
Cys Glu Lys Thr Asn Gly Thr Asn Ile His Leu Phe Leu Asn Leu Asn
130 135 140
Asp Thr Ile Asn Glu Tyr Thr Asn Lys Ser Phe Leu Asn Tyr Tyr Trp
145 150 155 160
Asn Ser Ser Glu Leu Asn Asn Ile Phe Leu Ala Thr Cys Ile Ile Asn
165 170 175
Asn Thr Leu Asn Ser Ala Asn Thr Thr Lys Val Ile Asn Cys Thr Asn
180 185 190
Pro Leu Leu Lys Ser Tyr Gln Asn Tyr Phe Leu Glu Asn Ile His Thr
195 200 205
Leu Phe Tyr Met Ile Ile Phe Ile Val Ser Gly Ile Thr Ile Ser Ile
210 215 220
Phe Ile Ser Ile Ile Thr Phe Leu Ser Leu Arg Lys Arg Lys Lys His
225 230 235 240
Val Glu Glu Ile Glu Ser Pro Pro Pro Glu Ser Asn Glu Glu Glu Gln
245 250 255
Cys Gln His Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu
260 265 270
Pro Leu Leu Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile
275 280 285
Tyr Tyr Met Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe Pro Leu Pro
290 295 300
Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro
305 310 315 320
Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro
325 330 335
Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Glu Ser Tyr Ser Pro Pro
340 345 350
Lys Pro Leu Pro Ser Ile Pro Leu Leu Pro Asn Ile Pro Pro Leu Ser
355 360 365
Thr Gln Asn Ile Ser Leu Ile His Val Asp Arg Ile Ile
370 375 380
<210> 31
<211> 402
<212> PRT
<213> African swine fever virus
<400> 31
Met Ile Ile Ile Val Ile Phe Leu Met Cys Leu Lys Ile Val Leu Asn
1 5 10 15
Asn Ile Ile Ile Trp Ser Thr Leu Asn Gln Thr Val Phe Leu Asn Asn
20 25 30
Ile Phe Thr Ile Asn Asp Thr Tyr Gly Gly Leu Phe Trp Asn Thr Tyr
35 40 45
Tyr Asp Asn Asn Arg Ser Asn Phe Thr Tyr Cys Gly Ile Ala Gly Asn
50 55 60
Tyr Cys Ser Cys Cys Gly His Asn Ile Ser Leu Tyr Asn Thr Thr Asn
65 70 75 80
Asn Cys Ser Leu Ile Ile Phe Pro Asn Asn Thr Glu Ile Phe Asn Arg
85 90 95
Thr Tyr Arg Leu Val Tyr Leu Asp Lys Lys Ile Asn Tyr Thr Val Lys
100 105 110
Leu Leu Lys Ser Val Asp Ser Pro Thr Ile Thr Tyr Asn Cys Thr Asn
115 120 125
Ser Leu Ile Thr Cys Lys Asn Asn Asn Gly Thr Asn Val Asn Ile Tyr
130 135 140
Leu Ile Ile Asn Asn Thr Ile Val Asn Asp Thr Asn Gly Asp Ile Leu
145 150 155 160
Asn Tyr Tyr Trp Asn Gly Asn Asn Asn Phe Thr Ala Thr Cys Met Ile
165 170 175
Asn Asn Thr Ile Ser Ser Leu Asn Glu Thr Glu Asn Ile Asn Cys Thr
180 185 190
Asn Pro Ile Leu Lys Tyr Gln Asn Tyr Leu Ser Thr Leu Phe Tyr Ile
195 200 205
Ile Ile Phe Ile Val Ser Gly Leu Ile Ile Gly Ile Phe Ile Ser Ile
210 215 220
Ile Ser Val Leu Ser Ile Arg Arg Lys Arg Lys Lys His Val Glu Glu
225 230 235 240
Ile Glu Ser Pro Pro Pro Ser Glu Ser Asn Glu Glu Asp Ile Ser His
245 250 255
Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu Pro Leu Leu
260 265 270
Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile Tyr Tyr Met
275 280 285
Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe Pro Leu Pro Lys Pro Cys
290 295 300
Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
305 310 315 320
Pro Cys Pro Pro Pro Lys Pro Cys Ser Pro Pro Lys Pro Cys Arg Pro
325 330 335
Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys
340 345 350
Pro Pro Pro Lys Pro Cys Pro Pro Ser Lys Pro Cys Pro Ser Pro Glu
355 360 365
Ser Tyr Ser Pro Pro Lys Pro Leu Pro Ser Ile Pro Leu Leu Pro Asn
370 375 380
Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser Leu Ile His Val Asp Arg
385 390 395 400
Ile Ile
<210> 32
<211> 402
<212> PRT
<213> African swine fever virus
<400> 32
Met Ile Ile Ile Val Ile Phe Leu Met Cys Leu Lys Ile Val Leu Asn
1 5 10 15
Asn Ile Ile Ile Trp Ser Thr Leu Asn Gln Thr Val Phe Leu Asn Asn
20 25 30
Ile Phe Thr Ile Asn Asp Thr Tyr Gly Gly Leu Phe Trp Asn Thr Tyr
35 40 45
Tyr Asp Asn Asn Arg Ser Asn Phe Thr Tyr Cys Gly Ile Ala Gly Asn
50 55 60
Tyr Cys Ser Cys Cys Gly His Asn Ile Ser Leu Tyr Asn Thr Thr Asn
65 70 75 80
Asn Cys Ser Leu Ile Ile Phe Pro Asn Asn Thr Glu Ile Phe Asn Arg
85 90 95
Thr Tyr Glu Leu Val Asp Leu Asp Lys Lys Ile Asn Tyr Thr Val Lys
100 105 110
Leu Leu Lys Ser Val Asp Ser Pro Thr Ile Thr Tyr Asn Cys Thr Asn
115 120 125
Ser Leu Ile Thr Cys Lys Asn Asn Asn Gly Thr Asn Val Asn Ile Tyr
130 135 140
Leu Ile Ile Asn Asn Thr Ile Val Asn Asp Thr Asn Gly Asp Ile Leu
145 150 155 160
Asn Tyr Tyr Trp Asn Gly Asn Asn Asn Phe Thr Ala Thr Cys Met Ile
165 170 175
Asn Asn Thr Ile Ser Ser Leu Asn Glu Thr Glu Asn Ile Asn Cys Thr
180 185 190
Asn Pro Ile Leu Lys Tyr Gln Asn Tyr Leu Ser Thr Leu Phe Tyr Ile
195 200 205
Ile Ile Phe Ile Val Ser Gly Leu Ile Ile Gly Ile Phe Ile Ser Ile
210 215 220
Ile Ser Val Leu Ser Ile Arg Arg Lys Arg Lys Lys His Val Glu Glu
225 230 235 240
Ile Glu Ser Pro Pro Pro Ser Glu Ser Asn Glu Glu Asp Ile Ser His
245 250 255
Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu Pro Leu Leu
260 265 270
Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile Tyr Tyr Met
275 280 285
Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe Pro Leu Pro Lys Pro Cys
290 295 300
Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
305 310 315 320
Pro Cys Pro Pro Pro Lys Pro Cys Ser Pro Pro Lys Pro Cys Arg Pro
325 330 335
Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys
340 345 350
Pro Pro Pro Lys Pro Cys Pro Pro Ser Lys Pro Cys Pro Ser Pro Glu
355 360 365
Ser Tyr Ser Pro Pro Lys Pro Leu Pro Ser Ile Pro Leu Leu Pro Asn
370 375 380
Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser Leu Ile His Val Asp Arg
385 390 395 400
Ile Ile
<210> 33
<211> 360
<212> PRT
<213> African swine fever virus
<400> 33
Met Ile Ile Leu Ile Phe Leu Ile Phe Ser Asn Ile Val Leu Ser Ile
1 5 10 15
Asp Tyr Trp Val Ser Phe Asn Lys Thr Ile Ile Leu Asp Ser Asn Ile
20 25 30
Thr Asn Asp Asn Asn Asp Ile Asn Gly Val Ser Trp Asn Phe Phe Asn
35 40 45
Asn Ser Phe Asn Thr Leu Ala Thr Cys Gly Lys Ala Gly Asn Phe Cys
50 55 60
Glu Cys Ser Asn Tyr Ser Thr Ser Ile Tyr Asn Ile Thr Asn Asn Cys
65 70 75 80
Ser Leu Thr Ile Phe Pro His Asn Asp Val Phe Asp Thr Thr Tyr Arg
85 90 95
Val Val Trp Asn Gln Ile Ile Asn Tyr Thr Ile Lys Leu Leu Thr Pro
100 105 110
Ala Thr Pro Pro Asn Ile Thr Tyr Asn Cys Thr Asn Phe Leu Ile Thr
115 120 125
Cys Lys Lys Asn Asn Gly Thr Asn Thr Asn Ile Tyr Leu Asn Ile Asn
130 135 140
Asp Thr Phe Val Lys Tyr Thr Asn Glu Ser Ile Leu Glu Tyr Asn Trp
145 150 155 160
Asn Asn Ser Asn Ile Asn Asn Phe Thr Ala Thr Cys Ile Ile Asn Asn
165 170 175
Thr Ile Ser Thr Ser Asn Glu Thr Thr Leu Ile Asn Cys Thr Tyr Leu
180 185 190
Thr Leu Ser Ser Asn Tyr Phe Tyr Thr Phe Phe Lys Leu Tyr Tyr Ile
195 200 205
Pro Leu Ser Ile Ile Ile Gly Ile Thr Ile Ser Ile Leu Leu Ile Ser
210 215 220
Ile Ile Thr Phe Leu Ser Leu Arg Lys Arg Lys Lys His Val Glu Glu
225 230 235 240
Ile Glu Ser Pro Pro Pro Glu Ser Asn Glu Glu Glu Gln Cys Gln His
245 250 255
Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu Pro Leu Leu
260 265 270
Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile Tyr Tyr Met
275 280 285
Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe Pro Leu Pro Lys Pro Cys
290 295 300
Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
305 310 315 320
Pro Cys Pro Ser Ala Glu Ser Tyr Ser Pro Pro Lys Pro Leu Pro Ser
325 330 335
Ile Pro Leu Leu Pro Asn Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser
340 345 350
Leu Ile His Val Asp Arg Ile Ile
355 360
<210> 34
<211> 198
<212> PRT
<213> African swine fever virus
<400> 34
Met Ile Ile Ile Val Ile Phe Leu Met Cys Leu Lys Ile Val Leu Asn
1 5 10 15
Asn Ile Ile Ile Trp Ser Thr Leu Asn Gln Thr Val Phe Leu Asn Asn
20 25 30
Ile Phe Thr Ile Asn Asp Thr Tyr Gly Gly Leu Phe Trp Asn Thr Tyr
35 40 45
Tyr Asp Asn Asn Arg Ser Asn Phe Thr Tyr Cys Gly Ile Ala Gly Asn
50 55 60
Tyr Cys Ser Cys Cys Gly His Asn Ile Ser Leu Tyr Asn Thr Thr Asn
65 70 75 80
Asn Cys Ser Leu Ile Ile Phe Pro Asn Asn Thr Glu Ile Phe Asn Arg
85 90 95
Thr Tyr Glu Leu Val Tyr Leu Asp Lys Lys Ile Asn Tyr Thr Val Lys
100 105 110
Leu Leu Lys Ser Val Asp Ser Pro Thr Ile Thr Tyr Asn Cys Thr Asn
115 120 125
Ser Leu Ile Thr Cys Lys Asn Asn Asn Gly Thr Asn Val Asn Ile Tyr
130 135 140
Leu Ile Ile Asn Asn Thr Ile Val Asn Asp Thr Asn Gly Asp Ile Leu
145 150 155 160
Asn Tyr Tyr Trp Asn Gly Asn Asn Asn Phe Thr Ala Thr Cys Met Ile
165 170 175
Asn Asn Thr Ile Ser Ser Leu Asn Glu Thr Glu Asn Ile Asn Cys Thr
180 185 190
Asn Pro Ile Leu Lys Tyr
195
<210> 35
<211> 357
<212> DNA
<213> African swine fever virus
<400> 35
atgttggtaa tctttttggg aattcttggc cttctggcca gccaggtctc aagtcaacca 60
gatggacaac ttcgtccaac agaggatcct ccagaagaag aacttaaata ttggtgcacc 120
tacatggaaa gttgccagtt ttgttgggac tgccaagatg gcaattgtat aaacaaagta 180
gatgggtcag tcatttataa aaatgagttt gtgcgaccat gttcagtttc ccgctggatg 240
aataaatgta tgtatgattt aaataagggt atctatcata caatgaattg ttctcagcca 300
cagtcttgga atccctacaa atacttcagg aaggagtgga aaaaagatga actctag 357
<210> 36
<211> 357
<212> DNA
<213> African swine fever virus
<400> 36
atgttggtga tctttttggg aattcttggc cttctggcca gccaggtctc aagtcagcca 60
gttggacaac ttcgtccaac agaggaccct ccagagaatg aactcgaata ttggtgcacc 120
tacatggaaa gttgccagtt ttgctgggac tgtcaagatg gcaattgtat aaacaaagta 180
gatgggtcag tcatttataa aaatgagtat gtgcaaccat gttcagtttc ccgctggcta 240
aataaatgta tgtatgattt agataagggt atctatcata caatgaactg ttctcagcca 300
cggtcttgga atccctacaa atgtttcagg aaggagtgga aaaaagatga actctag 357
<210> 37
<211> 369
<212> DNA
<213> African swine fever virus
<400> 37
atgttggtga tctttttggg aattcttggc cttatggcca gccaggtctt agggctacca 60
tctaatcaac caactggaca acttcgtcca acagaggatc ctccagagga agaactcgaa 120
tactggtgtg cctacatgga aagttgccag ttttgctggg actgccaaga tggcaattgc 180
ataaacaaaa tagatgggtc agtcatttat aaaaatgagt ttgtgcgacc atgttcagtt 240
tcccgctgga tggataaatg tatgtatgat ttaaataagg gtatctatca tacaatgaat 300
tgttctcagc cacagtcttg gaatccctac aaatacttca ggaaggagtg gaaaaaagat 360
gaactctag 369
<210> 38
<211> 357
<212> DNA
<213> African swine fever virus
<400> 38
atgttggtga cctttttggg aattcttggc cttctggcca gccaggtctc aagtcagctc 60
gttggacaac ttcgtccaac agaggatcct ccagaggaag aactcgaata ctggtgcgcc 120
tacatggaaa gttgccagtt ttgctgggac tgccaagatg gcaattgtat aaacaaaata 180
gatgggtcag tcatttataa aaatgagtat gtgcgaccat gttcagtttc ccgttcgatg 240
gataaatgta tgtatgattt aaataagggt atctaccata gcatgagctg ttctgaccca 300
aaggcctgga atccctacaa atacttcagg aaggaatgga aaaaagatga actctag 357
<210> 39
<211> 357
<212> DNA
<213> African swine fever virus
<400> 39
atgttggtga tctttttggg aattcttggc cttctggcca gccaggtttc aagtcaactc 60
gttggacaac ttcgaccaac agaggatcct ccagaggaag aactcgaata ctggtgcgcc 120
tacatggaaa gttgccaatt ttgctgggac tgccaagatg gcacttgtat aaacaaaata 180
gatgggtcag taatttacaa gaatgagtat gtgaaagcat gtctggtttc ccgttggctg 240
gataaatgta tgtatgattt agataaaggt atctaccata ccatgaattg ttctcagcca 300
tggtcttgga atccttacaa atacttcagg aaggaatgga aaaaagatga actctag 357
<210> 40
<211> 357
<212> DNA
<213> African swine fever virus
<400> 40
atgttggtga tcttcttggg aattcttggc cttctggcca gccaggtttc aagtcagctc 60
gttggacaac ttcgtccaac agaggatcct ccagaggaag aactcgaata ctggtgcgcc 120
tacatggaaa gttgccaatt ttgctgggac tgccaagatg gcacttgtat aaacaaaata 180
gatgggtcag taatttacaa gaatgagtat gtgaaatcat gtctggtttc ccgttggctg 240
gataaatgta tgtatgattt agataaaggt atctaccata ccatgaattg ttctcagcca 300
tggtcttgga atccttacaa atacttcagg aaggaatgga aaaaagatga actctag 357
<210> 41
<211> 357
<212> DNA
<213> African swine fever virus
<400> 41
atgttggtga tcttcttggg aatttttggc cttctggcca gccaggtttc aagtcagctc 60
gttggacaac ttcgtccaac agaggatcct ccagaggaag aactcgaata ctggtgtgcc 120
tacatggaaa gttgccaatt ttgctgggac tgccaagatg gcacttgtat aaacaaaata 180
gatgggtcag taatttacaa gaatgagtat gtgaaatcat gtctggtttc ccgttggctg 240
gataaatgta tgtatgattt agataagggt atctaccata ccatgaattg ttctcagcca 300
tggtcttgga atccttacaa atacttcagg aaggaatgga aaaaagatga actctag 357
<210> 42
<211> 357
<212> DNA
<213> African swine fever virus
<400> 42
atgttggtga tcttcttggg aattcttggc cttctggcca gccaggtttc aagtcagctc 60
gttggacaac ttcgtccaac agaggatcct ccagaggaag aactcgaata ctggtgcgcc 120
tacatggaaa gttgccaatt ttgctgggac tgccaagatg gcacttgtat aaacaaaata 180
gatgggtcag taatttacaa gaatgagtat gtgaaatcat gtctggtttc ccgttggctg 240
gataaatgta tgtatgattt agataaaggt atctaccata ccatgaattg ttctcagcca 300
tggtcttgga atccttacaa atacttcagg aaggaatgga aaaaagatga actctag 357
<210> 43
<211> 357
<212> DNA
<213> African swine fever virus
<400> 43
atgttggtga tcttcttggg aattcttggc cttctggcca gccaggtttc aagtcagctc 60
gttggacaac ttcgaccaac agaggatcct ccagaggaag aactcgaata ctggtgcgcc 120
tacatggaaa gttgccaatt ttgctgggac tgccaagatg gcacttgtat aaacaaaata 180
gatgggtcag taatttacaa gaatgagtat gtgaaatcat gtctggtttc ccgttggctg 240
gataaatgta tgtatgattt agataaaggt atctaccata ccatgaattg ttctcagcca 300
tggtcttgga atccttacaa atacttcagg aaggaatgga aaaaagatga actctag 357
<210> 44
<211> 375
<212> DNA
<213> African swine fever virus
<400> 44
atgaaggtgc tgattctagt actactgggg gtcgttatcc ttcaggctgc tcctatacgt 60
aaattagaag acctactgcc aacccgtaat cctccccaaa atgagctagt ttactggtgc 120
acctacgcaa accaatgtga cttttgctgg gaatgtgtac acggaatctg ccgaaacaga 180
attcaagcag attggcctgt gattcaccaa aatgactgga ttataaattg caccgtttcc 240
cgctggaatg gtatatgtag gtattatgaa ggacccagag tccatataga tcatgaaatg 300
gactgtgcaa atccaacatc ccatacttat ccacacattg aatacatgaa gatctatgaa 360
agagatgacc tatga 375
<210> 45
<211> 375
<212> DNA
<213> African swine fever virus
<400> 45
atgaaggtgc tgattctagt actactgggg gtcgttatcc ttcaggctgc tcctatacgt 60
aaattagaag acctactgcc aacccgtaat cctccccaaa atgagttagt ttattggtgc 120
acctacgcaa accaatgtga tttttgctgg gaatgtatac acggaatctg ccgaaacaga 180
attcaagcag attggcctgt gattcaccaa aatgactgga ttataaattg caccgtttcc 240
cgctggaatg gtatatgtag gtattatgaa ggacccagag gccatataga tcatgaaatg 300
gactgtgcaa atccaacata ccatacttat ccacacattg aatacatgaa gatttatgta 360
agagatgacc tatga 375
<210> 46
<211> 375
<212> DNA
<213> African swine fever virus
<400> 46
atgaaggtgc tgattctagt actgctggcg gtggttatcc ttcaagccgc tcctatacgt 60
aaattagaag atctactacc aacccgttat cctcctgacc atgagctagt ttattggtgc 120
acctacgcaa accaatgtga cttttgctgg gaatgcgtac acggtatctg ccgaaatagg 180
attcaagcag attggccggt tattcaccaa aatgactgga ttataaattg cacggtttcc 240
cgctggaatg gtatatgtag ttattatgaa ggacccagaa accatacaga tcatcaaatg 300
gactgtgcaa atccaacatc ccatacctat ccacatagag aatacatgaa aatttatgaa 360
agagatgact tataa 375
<210> 47
<211> 381
<212> DNA
<213> African swine fever virus
<400> 47
atgaaggtgc tgattctagt actactgggg ggggggggta ttattcttca ggccgctcct 60
atacgtaaat tagaagatct actaccaacc cgttatcctc ctgaacatga gctggtttat 120
tggtgcacct acgcaaacca atgtgacttt tgctgggaat gcgtccacgg tatttgccga 180
aacaggattc aagcagattg gccggttatt catcaaaatg actggattat aaattgcacg 240
gtttcccgct ggaatggcca atgtcattat tatgaaggtt ctcaacaata tctacatcat 300
gaaatggact gtacaaatcc aacatcccat acctatccac atacagaata catgaagatc 360
tatgaaagag atgacttatg a 381
<210> 48
<211> 375
<212> DNA
<213> African swine fever virus
<400> 48
atgaaggtgc taattctagt actactgggg gtggttatcc ttcaggccgc tcctatacgt 60
aaattagaag atctactacc aacccgttat cctcctgaac atgagctagt ttattggtgc 120
acttacgcaa accaatgtga cttttgctgg gaatgcgtcc acggtatctg ccgaaacagg 180
attcaagcag attggccagt tattcatcaa aatgactgga ttataaattg cacggtttcc 240
cgctggaatg gtatatgtag ttattatgaa ggacccagaa accatacaga tcatcaaatg 300
gactgtgcaa atccaacatc ccatacttat ccacatagag aatacatgaa gatctatgaa 360
agagatgact tatga 375
<210> 49
<211> 375
<212> DNA
<213> African swine fever virus
<400> 49
atgaaggtgc taattctagt actactgggg gtggttattc ttcaggccgc tcctatacgt 60
aaattagaag atctactacc aacccgttat cctcctgaac atgagctagt ttattggtgc 120
acttacgcaa accaatgtga cttttgctgg gaatgcgtcc acggtatctg ccgaaacagg 180
attcaagcag attggccagt tattcaccaa aatgactgga ttataaattg cacagtttct 240
cgctggaatg gtatatgtag ttattatgaa ggacccagaa accatacaga tcatcaaatg 300
gactgtgcaa atccaacatc ccatacttat ccacatagag aatacatgaa gatctatgaa 360
agagatgact tatga 375
<210> 50
<211> 375
<212> DNA
<213> African swine fever virus
<400> 50
atgaaggtgc taattctagt actactgggg gtggttattc ttcaggccgc tcctatacgt 60
aaagtagaaa atctactgcc aacccgtaat cctccccaaa atgaattagt ttattggtgc 120
acctatgcaa accaatgtga cttttgctgg gaatgcattc acggcatctg ccgaaacagg 180
attcaagcag attggccagt tattcatcaa aatgactgga ttataaattg cacggtttcc 240
cgctggaatg gccaatgtca ttattatgaa ggttctcaac aatatctgca tcatgaaatg 300
gactgtataa atccaacatc ccatacctat ccacatacag aatacatgaa gatctatgaa 360
agagatgact tatga 375
<210> 51
<211> 1128
<212> DNA
<213> African swine fever virus
<400> 51
ttaccgcaaa ttgtctctca gcgaagaaaa tgaatgaaac gtttctgtat attcataggt 60
tgaaattatt ttacgcactt cactaggttc taatattttc ttatgaagta ttgaatgggg 120
gcttaaaagt cctttcttaa aaagaagttt catcataaca ttcttttctt gtctaagaag 180
agtttcttgt attttttttg tataaggatt ggcacccaaa cttatacaaa aatgtacatt 240
actccaaata ccataatttg aaaagaaagt tatttcccta tttacttcat gattaatgaa 300
acctatcaac gtctctaagg ccgtattgat atttgcgcct aaggcaaaac aatagtatat 360
acccaattta ttttgagggt acatacaagc aagcgacatc atgtcatttg gatctaaacg 420
tatattttcc tgaaaatatg catgatggat ttcatcaaca ttacctaagt atacagccgt 480
ttttaaacgc caataatcta ggtgaggaaa tttcttacta agaaaacgaa taggttttat 540
aagattaaac tctatggcga tcttaaacca aaattttaat acatatgtat tttttatcat 600
tttttctttt tcatctaaat ttaagataaa acgattgtaa ataaagtcta tcaacacgta 660
aaaatcatgg ctatcaaaac tgtcgagaat cgaaatattg tcataataaa tatctatagc 720
taataagacc ttttgttgtt taattagatc aacaaacata ttatacaacc ctacatctaa 780
aaattttgga tcagctccta gttgaataca cagaactttc gtcctttccg tcttggcaca 840
tatgatgcca taattaatgt tggcacccca taaaacaaat aacttgatta gatcagtctg 900
gtttttcttc acagccctca ccaaggctct gtcaagctca tagctgtcaa catcagaaca 960
tgacatagag ccactggtta ccattttaca ttgtttacaa aaacctatgg gtccgttttc 1020
ccaccataat ccaagctgct gtaaaataaa aatatcatcc tcatgataat ttgaaaaagc 1080
cttgttttct atcaagactt tttttgtaag aacctgtaaa gaattcat 1128
<210> 52
<211> 1128
<212> DNA
<213> African swine fever virus
<400> 52
ttaccgcaaa ttgtctctca gcgaagaaaa tgaatgaaac gtttctgtat attcataggt 60
tgaaattatt ttacgcactt cactaggttc taatattttc ttatgaagta ttgaatgggg 120
gcttaaaagt cctttcttaa aaagaagttt catcataaca ttcttttctt gtctaagaag 180
agtttcttgt attttttttg tataaggatt ggcacccaaa cttatacaaa aatgtacatt 240
actccaaata ccataatttg aaaagaaagt tatttcccta tttacttcat gattaatgaa 300
acctatcaac gtctctaagg ccgtattgat atttgcgcct aaggcaaaac aatagtatat 360
acccaattta ttttgagggt acatacaagc aagcgacatc atgtcatttg gatctaaacg 420
tatattttcc tgaaaatatg catgatggat ttcatcaaca ttacctaagt atacagccgt 480
ttttaaacgc caataatcta ggtgaggaaa tttcttacta agaaaacgaa taggttttat 540
aagattaaac tctatggcga tcttaaacca aaattttaat acatatgtat tttttatcat 600
tttttctttt tcatctaaat ttaagataaa acgattgtaa ataaagtcta tcaacacgta 660
aaaatcatgg ctatcaaaac tgtcgagaat cgaaatattg tcataataaa tatctatagc 720
taataagacc ttttgttgtt taattagatc aacaaacata ttatacaacc ctacatctaa 780
aaattttgga tcagctccta gttgaataca cagaactttc gtcctttccg tcttggcaca 840
tatgatgcca taattaatgt tggcacccca taaaacaaat aacttgatta gatcagtctg 900
gtttttcttc acagccctca ccaaggctct gtcaagctca tagctgtcaa catcagaaca 960
tgacatagag ccactggtta ccattttaca ttgtttacaa aaacctatgg gtccgttttc 1020
ccaccataat ccaagctgct gtaaaataaa aatatcatcc tcatgataat ttgaaaaagc 1080
cttgttttct atcaagactt tttttgtaag aacctgtaaa gaattcat 1128
<210> 53
<211> 1128
<212> DNA
<213> African swine fever virus
<400> 53
ttaccgcaaa ttgtctctca gtaaagaaaa tgaatgaaac gtttctgtat attcataggt 60
tgaaattatt ttacgcactt caccaggttc taatattttt ttatgaagta ttgaatgggg 120
gcttaaaagt cctttcttaa aaagaagttt cattataaca ttcttttctt gtctaagaag 180
agtttcttgt attttttttg tataaggatt ggcacccaaa cttatacaaa aatgtacatt 240
actccaaata ccataatttg aaaagaaagt tatttcccta tttacttcat gattaatgaa 300
acctatcaac gtctctaagg cagtattgat atttgcacct aaggcaaaac aatagtatat 360
acctaattta ttctgagggt acatacaagc aagcggcatc atgtcatttg gatctaaacg 420
tatattttcc tgaaaatatg catgatggat ttcatcaaca ttacctaagt atacagccgt 480
ttttaaacgc caataatcta ggtaaggaaa tttcttacta agaaaacgaa taggttttat 540
aagattaaac tctatggcga tcttaaacca aaattttaat acatatgtat tttttatcat 600
tttttctttt tcatctaaat ttaagataaa acaattgtaa ataaagtcta tcaacacgta 660
aaaatcatgg ctatcaaacc tgtcgagaat cgaaatatta tcataataaa tatctatagc 720
taataagacc ttttgttgtt taattagatc aacaaacata ttatacaacc ctacatctaa 780
aaattttgga tcagctccta gttgaataca cagagctttc atcctttctg tcttggcgca 840
tatgatgcca taattaatgt tggcacccca taaaacaaat aacttgatta gatcagtctg 900
gtttttcttc acagccctca ccaaggctct gtcaagctca tagctgtcaa cgtcagagca 960
tgacatagcg ccactagtta ccattttaca ttgtttacaa aaacctatgg gaccgttttc 1020
ccaccatagt ccaagctgct gtaaaataaa aatatcatct tcatgatatt ttgaaaaagc 1080
cttgttttct atcaagactt tttttgtaag aacctgtaaa gaattcat 1128
<210> 54
<211> 1128
<212> DNA
<213> African swine fever virus
<400> 54
ttaccgcaaa ttgtctctca gcaaagaaaa tgaatgaaac gtttccgtat attcataggt 60
tgaaattatt ttacgcactt cactaggttc taatattttc ttatgaagta ttgaatgggg 120
gcttaaaagt cctttcttaa aaagaagttt cattataaca ttcttttctt gtctaagaag 180
agtttcttgt attttttttg tataaggatt ggcacccaaa cttatacaaa aatgtacatt 240
actccaaata ccataatttg aaaagaaagt tatttcccta tttacttcat gattaatgaa 300
acctatcaac gtctctaagg cagtattgat atttgcgcct aaggcaaaac aatagtatat 360
acctaattta ttctgagggt acatacaagc aagcgacatc atgtcatttg gatctaaacg 420
tatattttcc tgaaaatatg catgatggat ttcatcaaca ttacctaagt atacagccgt 480
ttttaaacgc caataatcta gatgaggaaa tttcttacta agaaaacgaa taggttttat 540
aagattaaac tctatggcga tcttaaacca aaattttaat acatatgtat tttttatcat 600
tttttctttt tcatctaaat ttaagataaa acaattgtaa ataaagtcta tcaatacgta 660
aaaatcatgg ctatcaaaac tgtcgagaat cgaaatatta tcataataaa tatctatagc 720
taataagacc ttttgttgtt taattagatc aacaaacata ttatacaatc ctacatctaa 780
aaattctgga ttggctccta gttcaataca caggtctttc gtcctttccg tcttggcaca 840
tatgatgcca taattaatgt tggcacccca taaaacaaac aacttgatta gatcagtctg 900
gtttttcttc acagccctta ccaaggctct gtcaagctca tagctgtcaa cgtcagagca 960
tgacatagag ccactggtta ccattttaca ttgtttacaa aaacctatgg ggccattatg 1020
ccaccacaat ccaagctgct gtaaaataaa aatatcatcc tcatgatatt ctgaaaaagc 1080
cttgttttct atcaagactt tttttgtaag aacctgtaaa gaattcat 1128
<210> 55
<211> 1128
<212> DNA
<213> African swine fever virus
<400> 55
ttaccgcaaa ttgtctctca gcaaagaaaa tgaatgaaac gtttccgtat attcataggt 60
tgaaattatt ttacgcactt cactaggttc taatattttc ttatgaagta ttgaatgggg 120
gcttaaaagt cctttcttaa aaagaagttt cattataaca ttcttttctt gtctaagaag 180
agtttcttgt attttttttg tataaggatt ggcacccaaa cttatacaaa aatgtacatt 240
actccaaata ccataatttg aaaagaaagt tatttcccta tttacttcat gattaatgaa 300
acctatcaac gtctctaagg cagtattgat atttgcgcct aaggcaaaac aatagtatat 360
acctaattta ttctgagggt acatacaagc aagcgacatc atgtcatttg gatctaaacg 420
tatattttcc tgaaaatatg catgatggat ttcatcaaca ttacctaagt atacagccgt 480
ttttaaacgc caataatcta gatgaggaaa tttcttacta agaaaacgaa taggttttat 540
aagattaaac tctatggcga tcttaaacca aaattttaat acatatgtat tttttatcat 600
tttttctttt tcatctaaat ttaagataaa acaattgtaa ataaagtcta tcaatacgta 660
aaaatcatgg ctatcaaaac tgtcgagaat cgaaatatta tcataataaa tatctatagc 720
taataagacc ttttgttgtt taattagatc aacaaacata ttatacaatc ctacatctaa 780
aaattctgga ttggctccta gttcaataca caggtctttc gtcctttccg tcttggcaca 840
tatgatgcca taattaatgt tggcacccca taaaacaaac aacttgatta gatcagtctg 900
gtttttcttc acagccctta ccaaggctct gtcaagctca tagctgtcaa cgtcagagca 960
tgacatagag ccactggtta ccattttaca ttgtttacaa aaacctatgg ggccattatg 1020
ccaccacaat ccaagctgct gtaaaataaa aatatcatcc tcatgatatt ctgaaaaagc 1080
cttgttttct atcaagactt tttttgtaag aacctgtaaa gaattcat 1128
<210> 56
<211> 1128
<212> DNA
<213> African swine fever virus
<400> 56
ttaccgcaaa ttgtctctca gcaaagaaaa tgaatgaaac gtttccgtat attcgtaggt 60
tgaaattatt ttacgcactt cactaggttc taatattttc ttatgaagta ttgaatgggg 120
gcttaaaagt cctttcctaa aaagaagttt cattataaca ttcttttctt gtctaagaag 180
agtttcttgt attttttttg tataaggatt ggcacccaaa cttatacaaa aatgtacatt 240
actccaaata ccataatttg aaaagaaagt tatttcccca tttacttcat gattaatgta 300
acgtatcaat gtctctaagg cagtattgat atttgcgcct aaggcaaaac aatagtatat 360
acctaattta ttctgagggt acatacaagc aagcggcatc atgtcatttg gatctaaacg 420
tatattttcc tgaaaatatg catgatggat ttcatcaaca ttacctaagt atacagccgt 480
ttttaaacgc caatcatcta ggtgaggaaa tttcttacta agaaaacgaa taggttttat 540
aagattaaac tctatggcga tcttaaacca aaattttaat acatatgtat tttttatcat 600
tttttctttt tcatctaaat ttaagataaa acaattgtaa ataaagtcta tcaacacgta 660
aaaatcatga ctatcaaacc tgtcgagaat cgaaatatta tcataataaa tatctatagc 720
taataagacc ttttgttgtt taattagatc aacaaacaaa ttatacaacc ctacatctaa 780
aaattttgga tcagctccta gttggataca tagaactttc gtcctttccg tcttggcaca 840
tatgatgcca taattaatgt tggcacccca taaaacaaat aacttgatta gatcagtctg 900
gtttttcttc acagccctca ccaaggctct gtcaagctca tagctgtcaa cgtcagagca 960
tgacatagag ccactggtta ccattttaca ttgtttacaa aaacctatgg ggccattatg 1020
ccaccatagt ccaagctgct gtaaaataaa aatatcatct tcatgataat ttgaaaaagc 1080
cttgttttct atcaagactt tttttgtaag aacctgtaaa gaattcat 1128
<210> 57
<211> 1128
<212> DNA
<213> African swine fever virus
<400> 57
ttactgcaaa ttgtctctca gcaaagaaaa tgaatgaaac gtttctgtat attcataggt 60
tgaaattatt ttacgcactt cattaggttc tattattttc ttatgaagta ttgaatgggg 120
gcttaaaagt cctttcttaa aaagaagttt cattataaca ttcttttctt gtctaagaag 180
agtttcttgt attttttttg tataaggatt ggcacccaaa cttatacaaa aatgtacatt 240
actccaaata ccataatttg aaaagaaagt tatttcccta tttccttcat gattaatgaa 300
acctatcaac gtctctaagg cagtattgat atttgcgcct aaggcaaaac aatagtatat 360
acctaattta ttctgagggt acatacaagc aagcgacatc atgtcatttg gatctaaacg 420
tatattttct tgaaaatatg catgatggat ttcatcaaca ttacctaagt atacagccgt 480
ttttaaacgc caatcatcta ggtgaggaaa tttcttacta agaaaacgaa taggttttat 540
aagattaaac tgtatggcga acttaaacca aaattttaat acaagtgtat tttttgtcat 600
ttcttctttt tcatctaagt ataggataaa acgattgtac ataaagtcta tcaacacgta 660
aaaatcatgg ctatcaaaac tgtcgagaat cgaaacatta tcataataaa tatctatagc 720
taataagacc ttttgttgtt taagtagatc aacaaacata ttatacaacc ctacatctaa 780
aaattttgga tcagctccta gttgaataca cagaactttc gtcctttccg tcttggcaca 840
tatgatgcca taattaatgt tggcacccca taaaataaat aacttgatta gatcagtctg 900
gtttttcttc acagccctca ccaaggctct gtcaagctca tagctgtcaa cgtcagagca 960
tgacatagag ccactggtta ccattttaca ttgtttacaa aaacctatgg ggccattatg 1020
ccaccatagt ccaagctgct gtaaaataaa aatatcatct tcatgatatt ctgaaaaagc 1080
cttgttttct atcaagactt tttttgtaag aacctgtaaa gaattcat 1128
<210> 58
<211> 1128
<212> DNA
<213> African swine fever virus
<400> 58
ttatcgtaaa ttgtctctta gcgaagaaaa tgaatgaacc gtttccgtat attgataggt 60
tgaaattatt ttacgcactt cactaggttc taatattttc ttatgaagta ttgaatgggg 120
gcttaaaagt cctttcttaa aaagtagttt cattataaca ttcttttctt ctctaagaag 180
agtttcttgt attttttttg tataaggatt ggcacccaaa cttatacaaa aatgtacatt 240
actccaaata ccataatttg aaaagaaagt tatttcccta tttacttcat gattaatgaa 300
acgtatcaac gtctctaagg cagtattgat atttgcccct aaggcaaaac aatagtatat 360
acctaactta ttttgagggt acatacaagc aagcgacatc atgttatttg gatctaaacg 420
tatattttcc tgaaaatatg catgatggat ttcatcaaca ttacctaagt atacagccgt 480
ttttaaacgc caatgatcta ggtgaggaaa tttcttacta agaaaacgaa taggttttat 540
aagattaaac tctatcgcga acttatacca aaattttaat acaagtgtat ttcttgtcat 600
ttcttctttt tcatctaaat ttaagataaa acgattgtaa ataaagtcta tcaacgtgta 660
aaaatcatgg tcatcaaaac tatcgagaat cgaaatatta tcataataaa tatctatagc 720
taataagact ttttgttgtt taagtagatc aacaaacata ttatacaacc ctacatctaa 780
aaattttgga tcagctccta gttgaagaca cagaactttt gtcctttccg tcttggcaca 840
cataatgcca taattaacgt tggcacccca taaaacaaat aacttgatta gatcagtctg 900
gtttttcttc acagccgtca ccaaggctct gtcaagctca tagctgtcaa catcagagca 960
tgacatagag ccactggtta ccattttaca ttgtttacaa aaacctatgg ggccatcatg 1020
ccaccacaac cctagctgct gtaaaataaa aatatcatcc tcatgataat ttgaaaaggc 1080
cttggtttct atcaagactt tttttgtaag aacctgtaaa gaattcat 1128
<210> 59
<211> 1128
<212> DNA
<213> African swine fever virus
<400> 59
ttaccgcaaa ttgtctctca gcgaagaaaa tgaatgaaac gtttccgtat attcataggt 60
tgaaattatt ttacgcactt caccaggttc taatattttt ttatgaagta ttgaatggga 120
ggttaaaagt cctttcttaa aaaagagttt cattataaca ttcttttctt ctctaagaag 180
agtttcttgt atttttttta tataaggatt ggcacccaaa cttatacaaa aatgtacatt 240
actccaaata ccataatttg aaaagaaagt tatttcccta tctacttcat gattaatgaa 300
acgtatcaac gtctctaagg cagtattgat atttgcacct aaggcaaaac aatagtatat 360
acctaattta ttttgagggt acatacaagc aagcgacatc atgtgatttg gatctaaacg 420
tatattttcc tgaaaatatg catgatggat ttcatcaaca ttacctaagt atacagccat 480
ttttaaacgc caatcatcta ggtgaggaaa tttcttacta agaaaacgaa taggttttat 540
aagattaaac tctatggcga tcttaaacca aaattttaat acaagtgtat ttcttgtcat 600
ttcttctttt tcatctaagt ataggatata acgattgtaa ataaagttta tcaatgcgta 660
aaaatcatgg ctatcaaaac tgtcgagaat gggaatgttt tcataataaa tatctatagc 720
taataagacc ttttgttgtt taaatagatc aacaaacata gtatacaacc ctacctctaa 780
aaatgttgga tcagctccta gttgaataca cagaactttc gtcctttcca tcttggcaca 840
tatgatgcca taattgatgt tggcacccca taaaacaaat aacttgatta gatcagtctg 900
atttttcttt acagccttca ccaaggctct gtcaagctca tagctgtcaa cgtcagagca 960
tgacatagag ccactggtta ccattttaca ttgtttacaa aaacctatag gtccgttttc 1020
ccaccataat tctagctgct gtaaaataaa aacatcatct tcatgataat ttgaaaaagc 1080
cttgttttct atcaagactt tttttgtaag aacctgtaaa gaattcat 1128
<210> 60
<211> 1122
<212> DNA
<213> African swine fever virus
<400> 60
ttaccgcaca ttgtctctca gcgaagaaaa tgaatgaaac gtttccgtat attgataggt 60
tgaaattatt ttacgcactt cactaggttc taatattttc ttatgaagta ttgaatgggg 120
gcttaaaagt cctttcttaa aaagtagttt cattatatca tacttttctt ctctaagaag 180
aatttcttgt attttttttg tataaggatt ggcacccaaa cttatacaaa aatgtacatt 240
actccaaata ccataatttg aaaagaaagg tctatttagt tcatgattaa tgaaacgtat 300
caacgcctct aaggcagtat tgatatttgc ccctaaggca aaacaatagt atatacctaa 360
tttattctga ggatacatac aagcaagcga catcatgtga tttggatcta aacgtatatt 420
ttcctgaaaa tatgcatgat ggatttcatc aacattccct aagtatacag ccgtttttaa 480
acgccaatca tctaggtgag gaaatttctt accaagaaaa cgaataggtt ttacaagatt 540
aaactctatg gcaaacttat accaaaattt taatacaagt gtattttttg ttattttttc 600
tttttcatct aaatttaaga taaaaccatt gtaaataaag tctatcaaca cgtaaaaatc 660
atggctatca aaactgtcga gaatcgaaat attatcataa taaatatcta tagctaataa 720
gaccttttgt tgtttaatta gatcaacaaa catattatac aaccctacat ctaaaaattt 780
tggatcagct cctagttgaa tacatagaac tttcgtcctt tccgtcttgg cacacacgat 840
gccaaaatta atttcggcgc cccataaaac aaataacttg attagatcag tttggttttc 900
cttcacagct tttactaagg ctctgtcaag ctcatagctg tcgacatcag aacatgacat 960
agagccaccg gttaccattt tacattgttt acaaaaacct atgggtccgt tttcccacca 1020
cagtccaagc tgctgtaaaa tgaaactatc atcttcatga taatttgaaa aagccttgtt 1080
ttctatcaag actttttttg taagaacctg taaagagttc at 1122
<210> 61
<211> 1128
<212> DNA
<213> African swine fever virus
<400> 61
ttaccgcaaa ttatctctca gtgaagaaaa tgaatgaaac gtttccgtat gttcataggt 60
tgaaattatt ttacgcacct cactaggttc taatattttt ttatgaagta ttgaatgggg 120
gcttaaaagt ccttttttaa aaagtagttt cattataaca ttcttttctt ctctaagaag 180
agtttcttgt attttttttg tatcagggtt ggcacccaaa cttatacaaa aatgtatatt 240
actccaaata ccataatttg aaaagaaagt tatttcccta tttacttcat gattaatgaa 300
acgtatcaac gtctctaagg cagtattgat atttgcgcct aaggcaaaac aatagtatat 360
acctaattta ttctgagggt acatacaagc aaacgacatc atgtgatttg gatctaaacg 420
tatattttct tgaaaatatg catgatggat ttcatcaaca ttccctaagt atacagccgt 480
ttttaaacgc caatcatcta ggtgaggaaa tttcttacta agataacgga taggttttac 540
aagattaaac tctatggcga acttaaacca aaattttaat acaaatgtgt ttcttgtcat 600
tttttctttt tcatctaaat ttaggataaa acgattgtaa ataaagttta tcaacgcgtg 660
aaaatcatgg ctattaaagc tgtcgagaat caaaatatta tcataataaa tatctatggc 720
taataagacc ttttgttgtt taattagatt aacaaacata ttatacagct ttttatctaa 780
aaattctgga tcggctccta gttgaataca caggtctttc gtcctttcca tcttagcaca 840
cataatgcca taattaatgt tggcacccca taaaacaaat aatatgatta gatcagtttg 900
gttttccttc acagctttta ctaaggccct gtcaagctca tagctgtcaa catcagagca 960
tgacattgag ccaatggtta ctattttaca ttgtttacaa aaacctatgg ggccgttttc 1020
ccaccacaat cctagctgct gtaaaataaa actatcatct tcatgataat ttgaaaaggc 1080
cttgttttct attaagactt tttttgtaag aacctgtaaa gaattcat 1128
<210> 62
<211> 1038
<212> DNA
<213> African swine fever virus
<400> 62
ctaggccaac atacttttta atttatagtt ttttaataga tgatatattt tgttaggatc 60
tgcttctttt aacgttaata gcgaggagtc tgcactataa atgtctaatg ataaatgatg 120
agatatcaaa tagtaattcc gttgctctgc tagggccttt gcctcttcaa aggcgtcggc 180
tcccagatct atacaaaaga acaagttatc catattataa aatcgtacgc aggcaagcat 240
agctgaatta atattagctc ctaagagaaa acaataatat atggttaaaa aattgttatc 300
ttttgtgcag gccatccgca tcatttcatc cacgtccatg cggatctttt ccttttcata 360
caaattatgt aggtcaaaca gcttattaaa acaaagagca cagattaacc accacgtatt 420
tagatactta aaatgttggt aaacataaga aatggcctcc ctaagattat cctgcaatgc 480
cactataaaa cagtatatcg ttaacatatc accatccgac atattactta atatgtcggt 540
gtcttctact aaccttttca acttccaata tatggatgac cttatttccc ttataatgac 600
ataggctgga aagggattat cattaaaaag tttaagacat aagataatat tactgctagt 660
agtgccaggg tgtattaatt taaagaacat gtgcataatc ttctttttat ccacgcggta 720
cttggctcct aattcccagc aaaattctcg aacaggcggc gtattggcgc aaattaaccc 780
atagttgatg tctgcgcccc attctgtaaa cagttttatt aactgatagt tgttttcctt 840
tgtagccaac attagtgccg tattaaggtc caagccgtct gcaaagcttg gcagctttat 900
cagcatatgt ttgcaatcaa gggaaattgg ggccttatac caccatagtc cgcagcgttc 960
taagataaca tggtactcaa tagatacttg ctgtctggct agtacctttt tggcgaagga 1020
ttgtaaggaa ggaaacat 1038
<210> 63
<211> 1038
<212> DNA
<213> African swine fever virus
<400> 63
ctaggccaac atacttttta atttatagtt ttttaataga tgatatattt tgctaggatc 60
tgcttctttt aacgttaata gcgaggagtc tgcactataa atgtctaatg ataaatgatg 120
agatatcaaa tagtaattcc gttgctctgc tagggccttt gcctcttcaa aggcgtcggc 180
tcccagatct atacaaaaga acaagttatc catattataa aatcgtacgc aggcaagcat 240
agctgaatta atattagctc ctaagagaaa acaataatat atggttaaaa aattgttatc 300
ttttgtgcag gccatccgca tcatttcatc cacgtccatg cggatctttt ccttttcata 360
caaattatgt aggtcaaaca gcttattaaa acaaagagca cagattaacc accacgtatt 420
tagatactta aaatgttggt aaacataaga aatggcctcc ctaagattat cctgcaatgc 480
cactataaaa cagtatatcg ttaacatatc accatccgac atattactta atatgtcggt 540
gtcttctact aaccttttca acttccaata tatggatgac cttatttccc ttataatgac 600
ataggctgga aagggattat cattaaaaag tttaagacat aagataatat tactgctagt 660
agtgccaggg tgtattaatt taaagaacat gtgcataatc ttctttttat ccacgcggta 720
cttggctcct aattcccagc aaaattctcg aacaggcggc gtattggcgc aaattaaccc 780
atagttgatg tctgcgcccc attctgtaaa cagttttatt aactgatagt tgttttcctt 840
tgtagccaac attagtgccg tattaaggtc caagccgtct gcaaagcttg gcagctttat 900
cagcatatgt ttgcaatcaa gggaaattgg ggccttatac caccatagtc cgcagcgttc 960
taagataaca tggtactcaa tagatacttg ctgtctggct agtacctttt tggcgaagga 1020
ttgtaaggaa ggaaacat 1038
<210> 64
<211> 1071
<212> DNA
<213> African swine fever virus
<400> 64
ttacgacgtt gtatcattga tgtgataatc caaataggcc aacatacttt ttgatttata 60
gttgtttaat agatggtata tttttttagg gttcgcttct tttagcgtga atagagaggg 120
atctggatga tagatatcta atgacaaacg ttgtgatatt aaataatagt cccgctgctc 180
tgctagggct tttgcctctt cgaaggcatt ggctcccaag tctatacaaa agaacagatt 240
atctatatta aagaactgta tggcagcaag catggccata ttgatatcgg cccctaaaat 300
aaaacaataa tacatcgtta aaaagttatt atctttcgtg caagctatgc gcatcatttc 360
attaatgtct atgcgaatct tttcctgctc atagagataa tggaggtcag acagtttatt 420
aaaatacaga gcacagatta accaccacgt attcatgtgc ttaaaatgtt cgtaaaaata 480
cgagacggcc tccctaagat cattctgcaa ggccaccata aaacaatata tagttagcat 540
atcgccgtcc gaaacatcac gtagtaggtc ttcatcttct actaacctcc tcagcctcca 600
ataaagagac gactttattt cccttataat cacataggta ggaaaaggat tctcattaaa 660
aagcttatga cataagataa tatattgact tgttttgttc tctataaatt taaagaacat 720
gtgtatcacc ttttttttat ccatgcgata gttcgctcct aattcccaac aaaactctcg 780
ggtaggctgt gtattggcac aaatgtatcc atagttgatg tttgcacccc actccgtgaa 840
tagttttatt aattgatagt tgttttcctt tgcagctatc atcaatgccg tattgagatc 900
caggccatcc gcaaagtatg gcaaccttat taacatgtgt ttgcaatcaa gtgaaattgg 960
agccgtatac caccataacc cgcagtattt caaaatatga tagtagtctt caggcagcac 1020
atgctgactg gctaatatct ttttggcgaa agactgtaaa gaaggaaaca t 1071
<210> 65
<211> 1071
<212> DNA
<213> African swine fever virus
<400> 65
ttacgacgtt gtatcattat tgtgataatc caaataggcc gacatacttt ttgatttata 60
attgtttaat agatggtata tttttttagg gttcgcttct tttagcgtga atagagaggg 120
atctggatga tagatatcta atgacaaacg atgtgatatt aaataatagt cccgctgctc 180
tgctagggct tttgcctctt cgaaggcatt ggcccccaag tctatacaaa agaacagatt 240
atctatatta aaaaactgta tggcagcaag catcgccata ttgatatcgg cccctaaaat 300
aaaacaataa tacatcgtta aaaagttgtt atctttcgtg caagctatgc gcatcatttc 360
attaatgtct atgcgaattt tttcctgctc atagagataa tggaggtcaa acagtttatt 420
aaaacacaga gcacagatta accaccacgt attcaggtgc ttaaaatgtt ggtaaaaata 480
cgagacggcc tccctaagac cattctgcaa ggccaccata aaacaatata aagttagcat 540
atcgccgtcc gaaacatcgc gtagtaggtc ttcgtcttct actaacctcc tcagcctcca 600
ataaagagac gactttattt cccttataat cacataggta ggaaaaggat tctcattaaa 660
aagcttatga cataagataa tatattgact cgttttgttc tctataaatt taaaaaacat 720
atgcatcacc ttttttttat ctaagcgata gttcgctcct aattcccaac aaaactctcg 780
agtaggctgt gtattggcac aaatgtatcc atagttgatg tttgcacccc actccgtgaa 840
cagttttatt aattgatagt tgttttcctt tgcagctatc atcaatgccg tattgaggtc 900
caggccatcc gcaaagtatg gcaaccttat taacatgtgt ttacaatcaa gtgaaattgg 960
agccttatac caccataacc cgcagcgctt caaaatatga tagtagtctt caggcagcac 1020
atgctggctg gctaatatct ttttggcgaa agattgcagg gaaggaaaca t 1071
<210> 66
<211> 1071
<212> DNA
<213> African swine fever virus
<400> 66
ttacgacgtt gtatcattaa tgtgataatc caaataggcc gacatacttt ttgatttata 60
gttgtttaat agatggtata tttttttagg gttcgcttct tttagcgtga atagagaggg 120
atctggatga tagatatcta atgacaaacg atgtgatatt aaataatagt cccgctgctc 180
tgctagggct tttgcctctt cgaaggcatt ggcccccaag tctatacaaa agaacagatt 240
atccatatta aagaactgta tggcagcaag catggccata ttgatatcgg cccctaaaat 300
aaaacaataa tacatcgtta aaaagttgtt atctttcgtg caagctatgc gcatcatttc 360
attaatgtct atgcgaattt tttcctgctc atagagataa tggaggtcaa acagtttatt 420
aaaacacaga gcacagatta accaccacgt attcaggtgc ttaaaatgtt ggtaaaaata 480
cgagacggcc tccctaagat cattctgcaa ggccaccata aaacaatata aagttagcat 540
atcgtcgtcc gaaacatcgc gtagtaggtc ttcgtcttct actaatctcc tcagcctcca 600
ataaagagac gactttattt cccttataat cacataggta ggaaaaggat tctcattaaa 660
aagcttatga cataagataa tatactgact cgttttgttc tctataaatt taaaaaacat 720
atgcatcacc ttttttttat ctaagcgata gtttgctcct aattcccaac aaaactctcg 780
agtaggctgt gtattggcac aaatgtatcc atagttgatg tttgcacccc actccgtgaa 840
cagttttatt aattgatagt tgttttcctt tgcagctatc atcaatgccg tattgaggtc 900
caggccatcc gcaaagtatg gcaaccttat taacatgtgt ttacaatcaa gtgaaattgg 960
agccttatac caccataacc cgcagcgctt caaaatatga tagtagtctt caggcagcac 1020
atgctggctg gctaatatct ttttggcgaa agattgcagg gaaggaaaca t 1071
<210> 67
<211> 1071
<212> DNA
<213> African swine fever virus
<400> 67
ttataacgat gtatcattga tgtcataatt caaataggcc aacatacttt ttgatttata 60
gttttttaat agacgatata ttttgttagg atctgcttct tttaacgtta atagcgagga 120
gtctggacta taaatgtcta atgataaacg atgagatatc aaatagtaat tctgttgctc 180
tgccaaggct tttgcctctt caaaggcatc ggcccccaga tctatacaaa agaacaggtt 240
atccatatta tagaatcgta tggaggcaat catggccaaa ttaatattag ctcctaagat 300
aaaacaataa tatatagtta aaaaattgtt atcttttgtg caggctatcc gcatcatttc 360
atccatgtcc atacggattt tttctttttc gtacaaatta tgtaggtcaa acagcttatt 420
atagcaaaga gcacatgtta accaccacgt attcagatac ttaaaatgtt ggtaaacata 480
agaaatggcc tccctaagat tatcctgcaa tgccacgata aaacagtata tagttaacat 540
atcaccatcc gaaatattac ttaatacgtt ggtatcttct gctaaatttt ttagcttcca 600
atgtatacac gactttattt cccttataat gacataggct gaaaagggat tgtcattaaa 660
aaatttaaga cataagataa tattattact agtagtgtta ggatgtatta atttaaagaa 720
tatgtgcata atcttctttt tatccacttg gtacttggct cctaattccc agcaaaattc 780
tcgaataggt ggcgtattcg cgcaaattaa cccatagttg atgtctgcgc cccaatccgt 840
aaacattttt attaattgat agttgttttc ctttgtagcc aacattagtg ccgtattaag 900
gtccaagcca tctgcaaagt ttggcagctt tatcagcata tgtttgcaat caagtgaaat 960
tggagcctta taccaccata gcccgcagcg ttctaagata acatggtaat caatagatac 1020
atgctgactg gctaatacct ttttggcgaa ggattgcaag gaaggaacca t 1071
<210> 68
<211> 1071
<212> DNA
<213> African swine fever virus
<400> 68
ttataacgat gtatcattga tgtcataatt caaataggcc aacatacttt ttgatttata 60
gttttttaat agacgatata ttttgttagg atctgcttct tttaacgtta atagcgagga 120
gtctggacta taaatgtcta atgataaacg atgagatatc aaatagtaat tctgttgctc 180
tgccaaggct tttgcctctt caaaggcatc ggcccccaga tctatacaaa agaacaggtt 240
atccatatta tagaatcgta tggaggcaat catggccaaa ttaatattag ctcctaagat 300
aaaacaataa tatatagtta aaaaattgtt atcttttgtg caggctatcc gcatcatttc 360
atccatgtcc atacggattt tttctttttc gtacaaatta tgtaggtcaa acagcttatt 420
atagcaaaga gcacatgtta accaccacgt attcagatac ttaaaatgtt ggtaaacata 480
agaaatggcc tccctaagat tatcctgcaa tgccacgata aaacagtata tagttaacat 540
atcaccatcc gaaatattac ttaatacgtt ggtatcttct gctaaatttt ttagcttcca 600
atgtatacac gactttattt cccttataat gacataggct gaaaagggat tgtcattaaa 660
aaatttaaga cataagataa tattattact agtagtgtta ggatgtatta atttaaagaa 720
tatgtgcata atcttctttt tatccacttg gtacttggct cctaattccc agcaaaattc 780
tcgaataggt ggcgtattcg cgcaaattaa cccatagttg atgtctgcgc cccaatccgt 840
aaacattttt attaattgat agttgttttc ctttgtagcc aacattagtg ccgtattaag 900
gtccaagcca tctgcaaagt ttggcagctt tatcagcata tgtttgcaat caagtgaaat 960
tggagcctta taccaccata gcccgcagcg ttctaagata acatggtaat caatagatac 1020
atgctgactg gctaatacct ttttggcgaa ggattgcaag gaaggaacca t 1071
<210> 69
<211> 1071
<212> DNA
<213> African swine fever virus
<400> 69
ttataacgat gtatcattga tgtcataatt caaataggcc aacatacttt ttgatttata 60
gttttttaat agacgatata ttttgttagg atctgcttct tttaacgtta atagcgagga 120
gtctggacta taaatgtcta atgataaacg atgagatatc aaatagtaat tctgttgctc 180
tgccaaggcc tttgcctctt caaaggcatc ggcccccaga tctatacaaa agaacaggtt 240
atccatatta tagaatcgta tggaggcaat catggccaaa ttaatattag ctcctaagat 300
aaaacaataa tatatagtta aaaaattgtt atcttttgtg caggctatcc gcatcatttc 360
atccatgtcc atacggattt tttctttttc gtacaaatta tgtaggtcaa acagcttatt 420
atagcaaaga gcacatgtta accaccacgt attcaaatac ttaaaatgtt ggtaaacata 480
agaaatggcc tccctaagat tatcctgcaa tgccacgata aaacagtata tagttaacat 540
atcaccatcc gaaatattac ttaatacgtt ggtatcttct gctaaatttt ttagcttcca 600
atgtatacac gactttattt cccttataat gacataggct gaaaagggat tgtcattaaa 660
aaatttaaga cataagataa tattactact agtagtgcta ggatgtatta atttaaagaa 720
tatgtgcata atcttctttt tatccacttg gtgcttggct cctaattccc agcaaaattc 780
tcgaataggt ggcgtattcg cgcaaattaa cccatagttg atgtctgcgc cccaatccgt 840
aaacattttt attaattgat agttgttttc ctttgtagcc aacattagtg ccgtattaag 900
gtccaagcca tctgcaaagt ttggcagctt tatcagcata tgtttgcaat caagtgaaat 960
tggagcctta taccaccata gcccgcagcg ttctaagata acatggtgat caatagatac 1020
atgctgactg gctaatacct ttttggcgaa ggattgcaag gaaggaaaca t 1071
<210> 70
<211> 1071
<212> DNA
<213> African swine fever virus
<400> 70
ttataacgtt gtattattga cgtcataatt caaataggcc aatatacttt ttgatttata 60
gttttttaat agatgatata ttttgttagg atccgcttct tttaacgtta ataacgagga 120
atctggacta taaatgtcta atgataaaca atgagatatc aaaaagtaat tccgttgctc 180
tgccagggct tttgcctcct caaaggcatc ggcccccagg tctatacaaa agaataagtt 240
atctatgtta tagaattgta tggaggcaat catagctaaa ttaatattag ctcctaagat 300
aaaacaataa tatatggtta aaaaattgtt atcttttgtg caggctatcc gcatcatttc 360
atccatgtcc atgcggatct tttccttttc atacaaatga tgtaggtcaa acaccttatt 420
atagcaaaga acacatgtta accaccacgt attcagatac ttaaaatgtt ggtaaacata 480
agaaatggcc tccctaagat tatcctgcaa tgccacgata aaacagtata tagttaacat 540
atctccatcc gaaatattac ttaatacgtt ggtatcttct gctaactttt ttagcttcca 600
atgtatacac gactttattt cccttataat gacataggct gaaaagggat tgtcattaaa 660
aagtttaaga cataagataa tattactact agtagtgcta ggatgtatta atttaaagaa 720
tatgtgcata atcttctttt tatccacttg gtacttggct cctaattccc agcaaaattc 780
tcgaacaggt ggcgtattcg cgcaaattaa cccatagttg atgtctgcgc cccaatccgt 840
aaacattttt attaattgat agttgttttc ctttgtagcc aacattagtg ccgtattaag 900
gtccaagcca tctgcaaagt ttggcagctt tatcagcata tgtttgcaat caagtgaaat 960
tggagcctta taccaccata gcccgcagcg ttctaagata atatggtgat caatggatac 1020
atgctgtctg gctagtacct ttttggcgaa ggattgtaag gaaggaaaca t 1071
<210> 71
<211> 1071
<212> DNA
<213> African swine fever virus
<400> 71
ttataacaat gtatcattga tatcatcatt caaataggcc aacatatttt ttgatttata 60
gttttttaat agatgattta ttttgttagg atctgtttct tttaacgtta atagcaagga 120
gtctggctta taaatgtcta atgataaacg atgagatatt aaatagtaat tccgttgctc 180
tgccagggct tttgcctctt caaaggcgtc ggctcccaga tctatacaaa agaacaagtt 240
atccatatta taaaatcgta cgcaggcaag catagctgaa ttaatattag ctcctaagag 300
aaaacaataa tatatagtta aaaaattgtt atcttttgtg caggccatcc gcatcatttc 360
atccacgtcc atgcggatct tttccttttc atacaaatta tgtaggtcaa acagcttatt 420
aaaacaaaga gcacagatta accaccacgt atttagatac ttaaaatgtt ggtaaacata 480
agaaatggcc tccctaagat tatcctgcaa tgccactata aaacagtata tcattaacat 540
atcaccatcc gacatattac ttaatatgtc ggtgtcttct actaaccttt tcagcttcca 600
atatatggat atccttattt cccttataat gacataggct ggaaagggat tatcattaaa 660
aagtttaaga cataagataa tattactgct agtagtgcca ggatgtatta atttaaagaa 720
catgtgtata atcttctttt tatccacgcg gtgcttggct cctaattccc agcaaaattc 780
tcgaacagac ggcgtattgg cgcaaattaa cccatagttg atgtctgcgc cccattccgt 840
aaacagtttt attaactgat agttattttc ctttgtagcc aacattagtg ccgtattaag 900
gtccaagccg tctgcaaagc ttggcagctt tatcagcata tgtttgcagt caagtgaaat 960
tggagcctta taccaccata gtccgcaacg ttctaagata acatggtact caatagatac 1020
ttgctgtctg gctagtacct ttttggcgaa ggattgtaag gaaggaaaca t 1071
<210> 72
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 72
tcatattgta tcatcatggt taaaatatgc cgtcatattt tttgatttat agttttttaa 60
tagatgatat attttgttag ggtccgcttc ttttaacgtt aatagcgagg agtctggact 120
ataaatgtct aatgataaac gatgagatat caaaaagtaa ttccgttgct ctgccagggc 180
ttttgcctct tcaaaggcat cggcccccaa gtctatacaa aagaacaggt tatccatatt 240
ataaaatcgt atggaggcaa tcatggccaa attaatatta gctcctaaga taaaacaata 300
atatatagtt aaaaaattgt tatcttttgt gcaggctatc cgcatcattt catccatgtc 360
catgcggatt ttttcctttt cgtacaaatt atgtaggtca aacagcttat taaaacaaag 420
agcacagatt agccaccacg tattcagata tttaaaatgt tggtaaacat aagaaatggc 480
ctccctaaga ttatcctgca atgccaccat aaaacagtat atcgttaaca tatcaccatc 540
cgaaatatta cttaatacgt cggtgtcttc tactaacttt ttcagcttcc aatatatgga 600
tgactttatt tcccttataa tgacataggc tgaaaagggg ttatcattaa aaagtttaag 660
acataagata atattactgc tagtagtgcc aggatgtatt aatttaaaga acatgtgcat 720
aatcttcttt ttatccacgc ggtacttggc tcctagttcc cagcacaatt ctcgaacagg 780
cggcgtattg gcgcaaatta acccatagtt gatgtctgcg ccccattccg taaacagttt 840
tattaactga tagttgtttt cctttgtagc caacattagt gccgtattaa ggtccaagcc 900
atctgcaaag cttggcagct ttatcagcat atgtttgcaa tcaagggaaa ttggagcctt 960
ataccaccat agtccgcagc gttctaagat aacatggtaa tcaatagata catgctgtct 1020
ggctagtacc tttttggcga aggattgtaa ggaaggaaac at 1062
<210> 73
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 73
tcatattgta tcatcatggt taaaatatgc cgtcatattt tttgatttat agttttttaa 60
tagatgatat attttgttag ggtccgcttc ttttaacgtt aatagcgagg agtctggact 120
ataaatgtct aatgataaac gatgagatat caaaaagtaa ttccgttgct ctgccagagc 180
ctttgcctct tcaaaggcgt cggcccccag gtctatacaa aagaacaggt tatccatatt 240
atagaatcgt atggaggcaa tcatggccaa attaatatta gctcctaaga taaaacaata 300
atatatagtt aaaaaattgt tatcttttgt gcaggctatc cgcatcattt catccatgtc 360
catgcggatt ttttcctttt cgtacaaatt atgtaggtca aacagcttat taaaacaaag 420
agcacagatt agccaccaca tattcagata cttaaaatgt tggtaaacat aagaaatggc 480
ctccctaaga ttatcctgca atgccaccat aaaacagtat atcgttaaca tatcaccatc 540
tgaaatatca cttaatacgt cggtgtcttc tactaacttt ctcagcttcc aatatatgga 600
tgactttatt tcccttataa tgacataggc tgaaaagggg ttatcattaa aaagtttaag 660
acataagata atattactgc tagtagtgcc aggatgtatt aatttaaaga acatgtgcat 720
aatcttcttt ttatccacgc ggtacttggc tcctagttcc cagcacaatt ctcgaacagg 780
cggtgtattg gcgcaaatta acccatagtt gatgtctgcg ccccattccg taaacagttt 840
tattaactga tagttgtttt cctttgtagc caacattagt gccgtattaa ggtccaagcc 900
atctgcaaag cttggcagct ttatcagcat atgtttgcaa tcaagtgaaa ttggagcctt 960
ataccaccat agtccgcagc gttctaagat aacatggtaa tcaatagata catgctgtct 1020
ggctagtacc tttttggcga aggattgtaa ggaaggaaac at 1062
<210> 74
<211> 1068
<212> DNA
<213> African swine fever virus
<400> 74
ttacactgtg tcatgcccat catagtcaaa atataccatc atattttttg atttatagtt 60
ttttaataga tgatatattt ttttaggatc tgcttctttt aacgttaata gcgaggagtc 120
tggactataa atatctattg ataaacgatg atacatcaaa aagtaattcc gctggtctgc 180
cagggctttt gcctcttcaa aggcatcggc tcccaggtct atacaaaaga acaagttatc 240
catattatag aattgtacgc aggcaagcat agcctgatta atattagctc ctaagagaaa 300
acagtaatat atggttaaaa agttgttatc tttagtgcag gctatgcaca tcatttcatc 360
catgtccatg cggatctttt ccttttcata caaatcatgt aggtcaaaca gcttattaaa 420
acaaagagca cagattaacc accacgtatt cagatgctta aaatgttggt aaaaataaga 480
aatggcctcc ctaagattat cctgcaatgc caggataaaa cagtatatag tcaacatatc 540
atcatccgac atattactta atatgtcagt gtcttctact aaccttctca gcttccaata 600
tatagacgac tttatttccc ttataatgac ataggttgga aaaggattat tattaaaaag 660
tttaagacat aagataatat tactactagt agtgccatga tgtattaatt taaaaaacat 720
atgcataacc ttatttttat ccacttggta cttggctcct aattcccagc aaaattctcg 780
aacaggcggc gtattagcgc aaattaatcc atagttgatg tccgcgcccc attccgtaaa 840
cagttttatt aactgatagt tgttttcctt tgtagccaac attagtgccg tattaaggtc 900
caagccatct gcaaagcttg gcagctttat taacatatgt ttgcaatcaa gtgaaattgg 960
agccttatac caccatagtc cgcaatgttt taagatataa tgataatcaa tggatacatg 1020
atgtctagct aatacctttt tggcgaagga ttgtaaagaa ggaaacat 1068
<210> 75
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 75
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcaatttatt ttttcagggt ccgtaacgat cgacaacaga gaaataaccg gattgtaatg 120
ctttaatgat aaggcatggg ctatcagata attttccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcatcggcac ccaggtctat acaaaagaac aggtttccaa gattatagtt 240
ttgtatggaa acaagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggccgaatag ctataatctt ggatgcaggc tatgtgcatc atttcatcaa tatccatgcg 360
gaccctttct atttcgtaca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta gacgcgggta tttctggtaa aagtagcgga tagcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgctactgg ttttatcgcg cgttgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaaacaggtt gaccttataa ataatttatt gcgtcgaata tgaagcataa tggggccatt 960
atgccaccac aggccacaac acttcaggac atgatattga tctaccggta tacactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 76
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 76
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcaatttatt ttttcagggt ccgtaacgat cgacaacaga gaaataaccg gattgtaatg 120
ctttaatgat aaggcatggg ctatcagata attttccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcatcggcac ccaggtctat acaaaagaac aggtttccaa gattatagtt 240
ttgtatggaa acaagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggccgaatag ctataatctt ggatgcaggc tatgtgcatc atttcatcaa tatccatgcg 360
gaccctttct atttcgtaca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta gacgcgggta tttctggtaa aagtagcgga tagcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgctactgg ttttatcgcg cgttgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaaacaggtt gaccttataa ataatttatt gcgtcgaata tgaagcataa tggggccatt 960
atgccaccac aggccacaac acttcaggac atgatattga tctaccggta tacactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 77
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 77
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gtaatttatt ttttcagggt ccataacgtt cgacaacaga gaaatgactg gattgtaatg 120
ctttaatgat aaggcatggg ctatcagata attttccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcgttggcgc ccaggtctat acaaaagaac aggtttccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggccgaatag ctataatctt ggatgcaggc tatgtgcatc atttcatcga tatccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc caccgatgta ggcgcgggta tttctggtaa aagtagcgaa tagcatcttt 480
gaggtcatag tccaccgcta tagcatacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtct agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgctactgg ttttatcgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atagtttatt acgtcgaata tgaagcataa tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgaca cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 78
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 78
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gtaatttatt ttttcagggt ccataacgtt cgacaacaga gaaatgactg gattgtaatg 120
ctttaatgat aaggcatggg ctatcagata attttccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcgttggcgc ccaggtctat acaaaagaac aggtttccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggccgaatag ctataatctt ggatgcaggc tatgtgcatc atttcatcga tatccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc caccgatgta ggcgcgggta tttctggtaa aagtagcgaa tagcatcttt 480
gaggtcatag tccaccgcta tagcatacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtct agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgctactgg ttttatcgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atagtttatt acgtcgaata tgaagcataa tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgaca cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 79
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 79
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gtaatttatt ttttcagggt ccataacgat cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcatggg ctatcagata atttcccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcgttggcgc ccaggtctat acaaaagaac aggtttccaa gattatagtt 240
ttgtatggaa accagcatag cttgattgat gttggctccc atgataaaac agtagtaaat 300
gaccgaatag ctataatctt ggatgcaggc tatgtgcatc atttcatcaa tatccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta ggcgcgggta tttctggtaa aagtagcgaa tagcatcttt 480
gaggtcatag tccaccgcta tagcatacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtct agcatgaagg ttatctccat gagccctctt aactcccaca tgatttctcc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgctactgg ttttatcgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atagtttatt acgtcgaata tgaagcataa tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgaca cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 80
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 80
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcgatttatt ttttcagggt ccgtaaccac cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcattgg ctatcagata atttcccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcgttggcac ccaggtctat acaaaagaac aggttcccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtagat 300
ggctgaatag ctataatctt ggacgcaggc tatgtgcatc atttcatcaa tgtccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta gccgcgggta tttctggtaa aagtagcgga tagcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgttactgg ttttatcgcg cgttgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atattctatt acgtcgaata tgaagcatta tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgaca cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 81
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 81
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcgatttatt ttttcagggt ccgtaaccac cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcattgg ctatcagata atttcccttt tgttctgcca aagctttgcc 180
ctcttcaaag gcgttggcac ccaggtctat acaaaagaac aggttcccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggctgaatag ctataatctt ggacgcaggc tatgtgcatc atttcatcaa tgtccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta gccgcgggta tttctggtaa aagtagcgga tagcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgttactgg ttttatcgcg cgttgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atattctatt acgtcgaata tgaagcatta tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tctaccgaca cgcactgccc 1020
agccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 82
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 82
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcaatttatt tttttagggt ctgtaacgac cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcatcgg ctatcagata atttcccttt tgttctgcca aagctttgcc 180
ttcctcaaag gcgttggctc ccaggtctat acaaaagaac aggttcccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggccgaatag ctataatctt ggacgcaggc tatgtgcatc atttcatcaa tgtccatgcg 360
gaccctttct atttcgtaca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
catgagccgc cacctatgta gacgcgggta tttctggtaa aagtagcgga tcgcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtgc taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttcccc 600
cctcagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgttactgg ttttatcgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggcacccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atagtttatt acgtcgaatc tgaagcataa tgggtccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgaca cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 83
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 83
ttatctttgt tcataatcaa gaaaaatccc catatttatt gagtgataat tttttaacat 60
gcgatttatt ttttcagggt ccgtaaccac cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcattgg ctatcagata atttcccttt tgttctgcca aagctttgcc 180
ctcctcaaag gcgttggccc ccaggtctat acaaaagaac aggttcccaa gattatagtt 240
ttgtatggaa accagcatgg cttgattgat gttggctccc atgataaaac agtagtaaat 300
ggctgaatag ctataatctt ggacgcaggc tatgtgcatc atttcatcaa tgtccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagagcgca 420
catgagccgc cacctatgta gccgcgggta tttctggtaa aagtagcgga tagcatcttt 480
gaggtcatag tccaccgcta tcgcgtacca gtatttggtt aaaacagtac taaagctatc 540
atcatggtcc agcatgaagg ttatctccat gagccctctt aactcccaca tgatttctcc 600
ccttagatcc agattatcta taatccttaa attggggtta ttggaaaaca cctcgtggca 660
aaagataata ttgttactgg ttttatcgcg cgttgtatca aagaaaattt ttaaaatata 720
ctctctttct aaatattctt tggctcccag ctctttgcac agatcacggg tattttccgt 780
gagagcacaa atcattccat agttaatatc tgcaccccat tcagtaaaca gctttatcaa 840
gtcatgatta ttctccttca cggctttcat cagtcctatg tttaactcga taccttgact 900
aaagcaggtt gaccttataa atattctatt acgtcgaata tgaagcatta tggggccatt 960
atgccaccac aggccacaac acttcaggat atgataatga tccaccgata cgcactgccc 1020
ggccagtact ttcttcgtga gggattgcag ggaaggcaac at 1062
<210> 84
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 84
ttatcttcgt tcataatcaa gaaaaaccct catatttatt gagtgataat tttttaacat 60
gcaatttatt ttttcagggt ccataatgac cgacaacaga gaaatgaccg gattgtaatg 120
ctttaatgat aaggcatcgg ctatcagata attttccttt tgttctgcca aagctttccc 180
ctcctcaaag gcgttggccc ccagatctat acaaaagaac atgttcccaa gattatagtt 240
ttgtatagaa acaagcatgg cttgattgat gttggccccc atgataaaac agtaataaat 300
agccgcatag ctataatctt ggacgcaggc tatgtgcatc atttcatcaa tatccatgcg 360
gaccctttct attacataca gctcgtgaag gtcgaacacg ttgttgtaaa aaagggcgca 420
cataagccgc cagtggtgta gatgggtata cctctgataa aaataatgga tagccttttt 480
gaggccatag tctaccgcta tggcgtacca gtatttggtt aacatattgc taaaggagtt 540
gtcatggtcc aacatgtagg ttatctccat gagtcccctt agctcccaca tgatttcctc 600
cctcagatcc aaattatcca catttttcag gttggggtta ttggaaaaca tttcgtggca 660
taagataata ttactgtcgg ttttgttgcg cgtcgtatca aagaaaattt ttaaaatata 720
atctctatct aaacgatctt tggctcctag ttctctgcat agattacggg tgtgctccgt 780
atgggcacaa atcagtccat aattaatatc ggcaccccac tcggcaaaca gccttatcaa 840
gtcatggttg ttttccttcg cggctttcat cagtacggtg ttcaattcaa taccctcgct 900
aaaacaggtt gaccttataa acattttgtg acgataaacg taaaatgtaa tagggccatc 960
ataccaccac aacccgcagc actttaagac atgatattga tctaccggta cacactgttt 1020
ggccagcact ttcttagtta aagattgtaa ggaaggcaac at 1062
<210> 85
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 85
ttatctgcgt tcataatcga gaaaaaccac catattcttt gagtgataat tttttaacat 60
agaatttatc ttttctgggt cggtcacggc cgacaacagg gaaatcaccg ggttataatg 120
ttttaatgat aaggcatcgg ctatcaaata attttccttt tgtattgcta gggttttgcc 180
ttcttcaaag gcgttggcac ccaggtctat acaaaagaac atgttcccga gattatagtt 240
ttgtatggaa acaaacatgg cttgattgat gttggccccc atgataaaac agtagtagat 300
agctgaatag ctataatctt ggatgcaggc tatgtgcatc atctcatcga tatccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacaca ttgttataaa aaagggcgca 420
cataagccgc caccgatgta gatgggtata cttctgataa aaatagtgga tggccttttt 480
gaggccgtag tctaccgcta tggcgtacca gtatttggtt aacatattgc tgaaggagtt 540
gtcatggtcc aacatgtagg ttatctccat gagtcccctt agctcccaca tgatttcctc 600
cctcagatcc aaatcatcca catgtttcag attggggtta ttggaaaaca tttcgtggca 660
taagataata ttactgtcgg ttttgttgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctatct aaacggtctt tggctccaag ttctctgcat agattgcggg tgtgctccga 780
atgagcacaa accagtccat aattaatatc ggcaccccac tcaacaaaca gccttatcaa 840
gtcatgattg ttttccttcg cggctttcat cagtacggtg ttcaattcaa taccctcgct 900
aaaacaggtt gactttataa acattttgtt acgatacgta taaaatgtaa tagggccatc 960
ataccaccac aacccgcagc atttcaggat atgatattga tctaccggta tacactgttt 1020
ggccagcact ttcttggata gggattgcaa ggaaggcaac at 1062
<210> 86
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 86
ttatctgcgt tcataatcga gaaaaaccac catattcttt gagtgataat tttttaacat 60
agaatttatc ttttctgggt cggtcacggc cgacaacagg gaaatcaccg ggttataatg 120
ttttaatgat aaggcatcgg ctatcaaata attttccttt tgtattgcta gggctttgcc 180
ttcttcaaag gcgttggcac ccaggtctat acaaaagaac atgttcccga gattatagtt 240
ttgtatggaa acaaacatgg cttgattgat gttggccccc atgataaaac agtagtaaat 300
agctgaatag ctataatctt ggatgcaggc tatgtgcatc atctcatcga tatccatgcg 360
gaccctttct atttcataca gctcgtgaag gtcgaacaca ttgttataaa aaagggcgca 420
cataagccgc caccgatgta gatgggtata cttctgataa aaatagtgga tggccttttt 480
gaggccgtag tctaccgcta tggcgtacca gtatttggtt aacatattgc tgaaggagtt 540
gtcatggtcc aacatgtagg ttatttccat gagtcccctt agctcccaca tgatttcctc 600
cctcagatcc aaatcatcca catgtttcag attggcgtta ttggaaaaca tttcgtggca 660
taagataata ttactgtcgg ttttgttgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctctatct aaacggtctt tggctccaag ttctctacat agattgcggg tgtgctccga 780
atgagcacaa accagtccat aattaatatc ggcaccccac tcaacaaaca gccttatcaa 840
gtcatgattg ttttccttcg cggctttcat cagtacggtg ttcaattcaa taccctcgct 900
aaaacaggtt gactttataa acattttgtt acgatacgta taaaatgtaa tagggccatc 960
ataccaccac aacccgcagc atttcaggat atgatattga tctaccggta tacactgttt 1020
ggccagcact ttcttggata gggattgcaa ggaaggcaac at 1062
<210> 87
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 87
ttatctgcgt tcataatcga gaaaaaccac catattcttt gagtgataat tttttaacat 60
agaatttatc ttttccgggt cggtcacggc cgacaacagg gaaatcaccg ggttataatg 120
ttttaatgat aaggcatcgg ctatcaaata attttccttt tgtattgcta gggctttgcc 180
ttcttcaaag gcgttggcac ccaggtctat acaaaagaac atgttcccga gattatagtt 240
ttgtatggaa acaaacatgg cttgattgat gttggcaccc atgataaaac agtagtaaat 300
agttgaatag ctataatctt ggatgcaggc tatgtgcatc atctcatcga tatccatgcg 360
gatcctttct atttcataca gctcgtgaag gtcgaacaca ttgttataaa aaagggcgca 420
catgagccgc caccgatgta gatgggtata cttctgataa aaatagtgga tggccttttt 480
gaggccgtag tctaccgcta tggcgtacca gtatttggtt aacatgttgc tgaaggagtt 540
gtcatggtcc aacatgtagg ttatctccat gagtcccctt agctcccaca tgatttcctc 600
cctcaggtcc aaatcatcca catgtttcag attggggtta ttggaaaaca tttcgtggca 660
taagataata ttactgtcgg ttttgttgcg cgtcgtatca aagaaaattt ttaaaatata 720
ctctttatct aaacggtctt tggcccctag ttctctgcat agatcgcggg tgtgctccga 780
atgagcacaa accagtccat aattaatatc ggcaccccac tcagtaaata attttattag 840
gtcatgattg ttttccttcg cggctttcat cagtacggtg ttcaattcaa taccctcgct 900
aaaacaggtt gactttataa acattttgtt acgatacgta taaaatgtaa tagggccatc 960
ataccaccac aacccgcaac ttttcaggat atgatattga tctaccggta tacactgttt 1020
ggccagcact tttttggata gggattgcaa ggaaggcaac at 1062
<210> 88
<211> 1053
<212> DNA
<213> African swine fever virus
<400> 88
tcatcttaaa tcataggtaa ggaagatcat catatttttt gaaacgtaat tttttaacgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatctataca aaagaacatg ttttctatat tatagtactg 240
tattgagcta agcatggctt gattgatgtt ggcgcccagg acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagt aatgtactga gcgaaaactc 540
attatttagc agatcggttt ttactattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtttccttgg cacctagctc tcgacagagg tcccaggtgt gctccgtgtt 780
gacagatacc agcccgtagt tgatgtccgc cccccactct gcaaacagtt ttataaggtt 840
gtagttgttt tcccttacag ccttcactaa cgccgtattt aggtttaagc cctctttaat 900
acctgctgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat catgccacca 960
taggtcataa cactttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 89
<211> 1053
<212> DNA
<213> African swine fever virus
<400> 89
tcatcttaaa tcataggtaa ggaagatcat catatttttt gaaacgtaat tttttaacgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatctataca aaagaacatg ttttctatat tatagtactg 240
tattgagcta agcatggctt gattgatgtt ggcgcccagg acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagt aatgtactga gcgaaaactc 540
attatttagc agatcggttt ttactattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtttccttgg cacctagctc tcgacagagg tcccaggtgt gctccgtgtt 780
gacagatacc agcccgtagt tgatgtccgc cccccactct gcaaacagtt ttataaggtt 840
gtagttgttt tcccttacag ccttcactaa cgccgtattt aggtttaagc cctctttaat 900
acctgctgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat catgccacca 960
taggtcataa cactttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 90
<211> 1053
<212> DNA
<213> African swine fever virus
<400> 90
tcatcttaaa tcataggtaa ggaagatcat catatttttt gaaacgtaat tttttaacgc 60
atgatctatg atttcagggt ccatgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatctataca aaagaacatg ttttctatat tatagtactg 240
tattgagcta agcatggcct gattgatgtt ggcgcccagg acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagt aatgtactga gcgaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtctccttgg cacctagctc tcgacagagg tcccaggtgt gctccgtgtt 780
gacagatacc agcccgtagt tgatgtccgc cccccactct gcaaacagtt ttataaggtt 840
gtagttgttt tcccttacag cctttactaa cgccgtattt aggtttaagc cctctttaat 900
acctgctgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat catgccacca 960
taggtcataa cactttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 91
<211> 1053
<212> DNA
<213> African swine fever virus
<400> 91
tcatcttaaa tcgtaggtaa ggaagatcat catatttttt gaaacgtaat tttttaacgc 60
atgatctata atttcagggt ccgtgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctt atacccttcc cctaaagcta tagtgccctc 180
ttcgaaagca tcagccccca gatccataca aaagaacatg ttttctatat tatagtactg 240
tattgaggta agcatggcct gattgatgtt ggcgcccagg acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagt aatgcactga gcgaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtctccttgg cacctagctc tcgacagagg tcccgggtgt gctccgtgtt 780
gacagatacc agcccatagt tgatgttcgc cccccactct gcaaacagtt ttataaggtt 840
gtaattgttt tcccttacag ccttcactaa cgccgtattt aggtctaagc cctctttaat 900
gcctgctgat tttatgagct ttaggttatg atcaaacgtg atcggaccat catgccacca 960
taggtcataa cactttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 92
<211> 1053
<212> DNA
<213> African swine fever virus
<400> 92
tcatcttaaa tcgtaggtaa ggaagatcat catatttttt gaaacgtaat tttttaccgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctt atacccttcc cctaaagcta tagtaccctc 180
ttcgaaagca tcagccccca gatccataca aaagaacatg ttttctacat tatagtactg 240
tattgaggta agcatggcct gattgatgtt ggcgcccaga acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatagat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccat gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagt aatgtactga gcgaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtctccttgg cacctagctc tcgacagagg tcccgggtgt gctccgtgtt 780
gacagatacc agcccatagt tgatgtccgc cccccactct gcaaacagtt ttataaggtt 840
gtagttgttt tcccttacag ccttcactaa cgccgtattt aggtctaagc cctctttaat 900
gcctgctgat tttatgagct ttaggttatg atcaaacgtg atcggaccat catgccacca 960
taggtcataa cactttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 93
<211> 1053
<212> DNA
<213> African swine fever virus
<400> 93
tcatcttaaa tcgtaggtaa ggaagatcat catatttttt gaaacgtaat tttttaacgc 60
atgatctata atttcagggt ccgtgctttt aggcaacggg gtggtggccg gactataaat 120
ctttagggat aaaatgttct ttataagctt atacccttcc cctaaagcta tagtgccctc 180
ttcgaaagca tcagccccca gatccataca aaagaacatg ttttctatat tatagtactg 240
tattgaggta agcatggcct gattgatgtt gccccccagg acatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcgat ccgcatcatc tcttctatgt ccatatgaat 360
cttgtccttt tcatacgcct catgaaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gttatagcgt atggctatag cgtaccagta tttaagtagt aatgtactga gcgaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttc 720
ttcattcaag gtctccttgg cacctagctc tcgacagagg tcccaggtgt gctccgtgtt 780
gacagatacc agcccatagt tgatgttcgc cccccactct gcaaacagtt ttataaggtt 840
gtagttgttt tcccttacag ccttcactaa cgccgtattt aggtctaagc cctctttaat 900
gcctgctgat tttatgagct ttaggttatg atcaaacgtg atcggaccat catgccacca 960
taggtcgtaa cactttaaaa gataatgttg gtttgtgggc acgcattgtc cagccaacac 1020
ctttttggtc agagattgca gggaaggcaa cat 1053
<210> 94
<211> 1053
<212> DNA
<213> African swine fever virus
<400> 94
tcatcttaaa tcataggaaa ggaagatcat catatttttt gaaaagtaat tttttaacgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg atggtggtcg gactataaat 120
ctttagagat aaaatgtttt ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatccataca aaagaacatg ttttctatat tatagtactg 240
tattgaggta agcatggcct gattgatgtt ggcgcccaac atatagcagt agtacatggt 300
tgaaaggttg tggtctttaa tgcaggcgat ccgcatcatc tcttctatgt ccatatagat 360
cttgtccttt tcatacgcct catggaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cttctttcag 480
gttatagcgt atggctatag cgtaccagta tttgagtagc aatgtactga gcgaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccaaaaaa tttctatcct 600
catttttata ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctata aaaatttgta aaatttcttt 720
ttcattcaag gtctccttgg cacctagctc tcgacagagg tcccaggtgt gctccgagct 780
gacagatacc agcccatagt tgatgtccgc cccccactct gcaaacaatt ttataaggtt 840
gtagttgttt tcctttacag ccttcaccaa cgccgtattt aggtctaagc cctctttaat 900
gcctgctgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat catgccacca 960
taggtcataa tattttaaaa gataatgttg gttcgtgggc acgcattgtc cggccaacac 1020
ctttttggtc aaagattgca gggaaggcaa cat 1053
<210> 95
<211> 1053
<212> DNA
<213> African swine fever virus
<400> 95
tcatcttaaa tcataggaaa ggaagatcat catatttttt gaaaagtaat tttttaacgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg atggtggtcg gactataaat 120
ctttagagat aaaatgtttt ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatccataca aaagaacatg ttttctatat tatagtactg 240
tattgaggta agcatggcct gattgatgtt ggcgcccaac atatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcaat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catggaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcaggt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gctatagcgt acggctatag cgtaccagta tttgagtagt aatgtactga gcaaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
caatttcaga ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctatg aaaatttgta aaatttcctc 720
ttcattcaag atctccttgg cacctaactc ttgacagagg tcccgggtat gctccgtgtt 780
gacagatacc agcccatagt tgatgtccgc cccccactct gtaaatagtt ttataaggct 840
gtagttgttt tcccttacag cctttactaa cgccgtattt aggtctaagc cctctttaat 900
gcctgatgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat tataccacca 960
tagatcataa tattttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc aaagattgca gggaaggcaa cat 1053
<210> 96
<211> 1053
<212> DNA
<213> African swine fever virus
<400> 96
tcatcttaaa tcataggaaa ggaagatcat catatttttt gaaaagtaat tttttaacgc 60
atgatctatg atttcagggt ccgtgctttt aggcaacggg atggtggtcg gactataaat 120
ctttagagat aaaatgtttt ttataagctc atacccttcc cctaaagctg tagtaccctc 180
ttcgaaaaca tcagccccca gatccataca aaagaacatg ttttctatat tatagtactg 240
tattgaggta agcatggcct gattgatgtt ggcgcccaac atatagcagt agtacatggt 300
tgaaaggttg tggtctttga tgcaggcaat ccgcatcatc tcttctatgt ccatatggat 360
cttgtccttt tcatacgcct catggaggtc aaacacatta ttaaaacaaa gagcacatgt 420
taaccgccac gtattcatgt gtgtatattt ttggtaaaaa tactgtatgg cctctttcag 480
gctatagcgt acggctatag cgtaccagta tttgagtagt aatgtactga gcaaaaactc 540
attatttagc agatcggttt tttctattaa ctcccttaac tcccagaaaa tttctatcct 600
caatttcaga ttatttactt tttgtaatat cggattgttg gaaaacacct catggcataa 660
aataatgtta ctactagttt tatgaaactt tagatctatg aaaatttgta aaatttcctc 720
ttcattcaag atctccttgg cacctaactc ttgacagagg tcccgggtat gctccgtgtt 780
gacagatacc agcccatagt tgatgtccgc cccccactct gtaaatagtt ttataaggct 840
gtagttgttt tcccttacag cctttactaa cgccgtattt aggtctaagc cctctttaat 900
gcctgatgat tttatgagcc ttaggttatg atcaaacgtg atcggagcat tataccacca 960
tagatcataa tattttaaaa gataatgttg gttcgtgggc acgcattgtc cagccaacac 1020
ctttttggtc aaagattgca gggaaggcaa cat 1053
<210> 97
<211> 1050
<212> DNA
<213> African swine fever virus
<400> 97
tcatcttaaa tcgtaggaaa ggaaggtcat catatttttt gatttataat tttttaacac 60
atgatctatt atttcagggt ccgtgttttt aggtaacggg gcagtggacg gactatagat 120
ctttagggat aaaatgttcc ttataagctc atacccttcc cctacaggca tattctcttc 180
gaaaacatca gcccccagat ccatacaaaa gaacatgttt tctatattat agtactgtat 240
tgaggcaagc atggcctgat taatgttggc gcccaggaca tagcagtagt atatcgttga 300
aaggttgtgg tctttgatgc aggctactcg catcatctct tctaagtcca tatagatctt 360
gtccttttca tacgcctcat gaaggtcaaa cacattatta aaacaaagag cacatgttaa 420
ccgccacgta ttcaggtgtg tatatttttg ataaaaatac tgtatggcct ctttcaggtt 480
atagcgtacg gctatagcgt accagtattt gagtaataat gtattgagtg aaaactcatt 540
atttaacaga tcggtttttt ttattaactc ccttaactcc cagaaaattt ctatcctcat 600
tttcagatta tttacttttt gtaataacgg attgttggaa aacacctcat ggcataaaat 660
aatgttacta ctagttttat aaaactttag atcgatgaaa attcgtaaaa tttcctcttc 720
atttaaggtc tccttggcgc ctagctctct gcagaggtcc cgggtgtgct ccgtgttgac 780
agataccagc ccgtagttga tgtccgcccc ccactctgta aaaagcttta taaggttgta 840
gttgttttcc cttacagcct ttactaacgc cgtatttagg tctaagccat ctttaatgcc 900
tgctgatttt atcagcccta ggttatgatc aaacgtgatc ggagaatcat accaccatag 960
gtcgtaacac tttaaaagat aatattggtc cgtcggcagg cattgtccag ccagtacctt 1020
tttggtcaga gattgcaggg aaggcaacat 1050
<210> 98
<211> 1056
<212> DNA
<213> African swine fever virus
<400> 98
tcatcttaga tcataagtaa ggaagaccat catatttttt gaaaagtaat tttttaactc 60
atgatctata atttcagggt ccgtgctttt aggcaacggg gtggtggccg ggctataaat 120
ctttagggat aaaatattcc ttataggctc atacccttcc tgtcccacta gagccatacc 180
ctcttcaaaa gcatcggccc ccagatccat acaaaagaat atgttttcta tattatagta 240
ctgtattgag gtaagcatgg cctgattgat gttggcgccc agcatatagc agtagtatat 300
cgttgaaagg ctgtggtctt tgatgcaggc tatccgcatc atctcttcta aatccataca 360
gatcttgtcc ttttcatacg cctcatgaag gtcaaacacg ttattaaaac aaagagcaca 420
tgttaatcgc cacgtattca ggtgcgtata tttttggtaa aaatactgta tggcctcttt 480
caagttgtag cgtacggcta tagcgtacca gtatttgagt aatagtgtat tgagcgaaaa 540
ctcattattt agcagatcgg ttttttctat tatctccctt aactcccaaa aaatttctat 600
cctcattttc aggttattta ccttttttaa aagtagatta tcggaaaaca cctcatgaca 660
taagataatg ttactactgg ttttatgaaa ctttaaatct atgaaaattt gtaaaatatc 720
cccttcattt aaggtcttct tggcgcctag ctctcgacag aggtcccagg tgtgctccgt 780
gttgacagat atcagcccgt agttgatgtt cgctccccac tccgtaaata gttttataag 840
actgtagttg ttttccttta cagccttcac taatgccatg tttaggtcta agccttcttg 900
aaggcctgct gattttatca gccttaggtt atgatcaaac gtgatcggag cattattcca 960
ccatagatcg taacacttta aaagataatg ttggtcctcg ggcagacatt gtccagccag 1020
cacctttttg gtcagagatt gcagggaagg caacat 1056
<210> 99
<211> 1056
<212> DNA
<213> African swine fever virus
<400> 99
tcatcttaga tcataagtaa ggaagaccat catatttttt gaaaagtaat tttttaacgc 60
atgatctata atttcagggt ccgtgctttt aggcaatggg gtagtggccg ggctataaat 120
ctttagggat aaaatattcc ttataggctc atacccttcc tgtcccacta gagccatacc 180
ctcttcaaaa gcatcggccc ccagatccat acaaaagaat atgttttcta tattatagta 240
ctgtattgag gtaagcatgg cctgattgat gttggcgccc agcatatagc agtagtatat 300
tgttgaaagg ttgtggtctt tgatgcaggc tatccgcatc atctcttcta aatccataca 360
gatcttgtcc ttttcatacg cctcatgaag gtcaaacacg ttattaaaac aaagagcaca 420
tgttaaccgc cacgtattca ggtgtgtata tttttggtaa aaatactgta tggcctcttt 480
caagttgtag cgtacggcta tagcgtacca gtatttgagt aatagtgtat tgagcgaaaa 540
ctcattattt agcagatcgg ttttttctat tatctccctt aactcccaaa aaatttctat 600
cctcattttc aggttattta ccctttttaa aagtaaatta tcggaaaaca cctcatgaca 660
taagataatg ttactactgg ttttataaaa ttttaaatct atgaaaattt gtaaaatatc 720
cccttcattt aaggtcttct tggcgcctag ctctcgacag aggtcccagg tgtgctccgt 780
gttgacagat atcagcccgt agttaatgtt cgccccccac tccgtaaata gttttataag 840
actgtagttg ttttccttta cagccttcac taatgccatg tttaggtcta agccttcttg 900
aatgcctgct aattttatca gccttaggtt atgatcaaac gtgatcggag cattattcca 960
ccatagatcg taacacttta aaagataatg ttggtcctcg ggcagacatt gtctagccag 1020
cacctttttg gtcaaagatt gcagggaagg caacat 1056
<210> 100
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 100
ctatagtata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gtaaatatcc aaagccaaac tatggctcag aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccagcg cgtaacagta 300
atatattgtt aatggattgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggatg ttttccttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cattaagatc cgtatatttc tcatctagaa aacaaatggc 480
gtccttacaa tcgtattgta ctgctttggc gtaccaatac ttcactagta aaccatttaa 540
ctcgtccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtataaca aatttgtttt ctaaaatagg attattcata aaaatttcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cctggtaaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ccatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc cacacgaagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattc ggccacgatc catacaaagc ttgagaggag catcatgcca 960
ccataggcca caatatttca aaatgcagtg ttcatctatt gacaaacact ggctggctat 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 101
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 101
ctatagtata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gtaaatatcc aaagccaaac tatggctcag aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccagcg cgtaacagta 300
atatattgtt aatggattgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggatg ttttccttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cattaagatc cgtatatttc tcatctagaa aacaaatggc 480
gtccttacaa tcgtattgta ctgctttggc gtaccaatac ttcactagta aaccatttaa 540
ctcgtccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtataaca aatttgtttt ctaaaatagg attattcata aaaatttcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cctggtaaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ccatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc cacacgaagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattc ggccacgatc catacaaagc ttgagaggag catcatgcca 960
ccataggcca caatatttca aaatgcagtg ttcatctatt gacaaacact ggctggctat 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 102
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 102
ctatagtata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gtaaatatcc aaagccaaac tatggctcag aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccagcg cgtaacagta 300
atatattgtt aatgggttgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggatg ttttccttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cattaagatc cgtatatttc tcatctagaa agcaaatggc 480
gtccttacac tcgtattgta ctgctttggc gtaccaatac ttcactagta aaccgtttaa 540
ctcatccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtatagta aatttatctt ctatattagg attattcata aatatatcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cttggtgaaa atacggaaaa tatcgtcgtc 720
ttctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ctatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc tatatggagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattt ggccacgatc catacaaagc ttgaggggga catcatgcca 960
ccataggcca cagtgtttca gaatgcagtg ttcatctatc gacaaagact ggttggctac 1020
cgtctttttg acgagggtct gcagagagag cggtaatgac at 1062
<210> 103
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 103
ctatagtata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcctt 60
taataaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gtaaatatcc aaagtcaaac tatggcttag aaaatgataa cctttttgtt ccgctatagc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccaggg cgtaacaata 300
atatattgtt aatggattgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggact ttttccttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cattaagatc cgtatatttc tcatctagaa agcaaatggc 480
gtccttacac tcgtattgta ctgctttggc gtaccaatac ttcactagta aatcgtttaa 540
ctcatccgtt tcttttattt ctatgagccc ccatagtctt ttacaaatta agccccttaa 600
ttgtatagta aatttgtttt ctatattagg attattcata aatatctcat ggcacaaaat 660
aatacggccg ctggttttat tgtgcattat cttggtgaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcac ctagctgtct acacaactct cggatgtgct ccgtattgat 780
agaaagcaaa ctatagttga tatgtgcgcc ccattctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc tatatggagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattt ggccacgatc catacaaagc ttgaggggga catcatgcca 960
ccataggcca cagtgtttca gaatgcagtg ttcatctgtc gacaaacact ggctggctac 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 104
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 104
ctatagtata ttatgagaat attcccaaat gatggataag ttttttgatt tataaccctt 60
taataaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gtaaatatcc aaagccaaac tatggcttag aaaatgataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccaggg cgtaacagta 300
atatattgtt aatggattgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggact ttatccttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cattaagacc cgtatatttc tcatctagaa agcaaatggc 480
gtccttacac tcgtattgta ctgctttggc gtaccaatac ttcactagta aatcgtttaa 540
ctcatccgtt tcttttattt ctatgagcct ccatagtctt ttacaaatta agccccttaa 600
ttgtatagta aatttgtttt ctatattagg attattcata aatatctcat ggcacaaaat 660
aatacggccg ctggttttat tgtgcattat cttggtgaaa atacggaaaa tatcgttgtc 720
ctctagagtt tttttggcac ctagctgtct acacaactct cggatgtgtt ccgtattgat 780
agaaagcaaa ctatagttga tatgtgcgcc ccattctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc tacatggaga tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattt ggccacgatc catacaaagc ttgaggggga catcatgcca 960
ccataggcca cagtgtttca gaatgcagtg ttcatctgtc gacaaacact ggctggctac 1020
cgtttttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 105
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 105
ctatagtata ttatgagaat attcccaaat tatggataag ttttttgatt tataatcctt 60
taaaaaactg cttatttctt cggggtcctt taagtttagt ggcaaggaag catctgagct 120
gaaaatatcc aaagccaaac tatggcttag aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt attgaagtaa gcatagcttg gttgatgttg ccccccaggg cgtaacagta 300
atatattgtt aatggattgt tatccttggt agaagccaga catatcatgt catggacgtc 360
tatttggact ttttccttgt ggtacatctc atgaagctca tatattttgt taaaatacag 420
gagacatttt aatcgccatt cattaagatc cgtatatttc tcttctagaa agcaaatggc 480
gtccttacac tcgtattgta ctgctttggc gtaccaatac ttcactagta aatcgtttaa 540
ctcatccgtt tcttttattt ctatgagccc ccatagtctt ttacaaatta agccccttaa 600
ttgtatagta aatttgtttt ctatattagg attattcata aatatatcat ggcacaaaat 660
aatacggccg ctggttttat tgtgcattat cttggtgaaa atacggaaaa catcgtcgtc 720
ttctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct ccgtattaat 780
agaaagcaaa ctatagttga tatgtgcgcc ccattctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc tatatggagg tctatatcct ctcctaaaaa 900
tcctgatttt atttgtattt ggccacgatc catacaaagc ttgaggggga catcatgcca 960
ccataggcca cagtgtttca gaatgcagtg ttcatctatc gacaaacact ggctggctac 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 106
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 106
ctataatata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttctt cggggtcctt taagtttaat ggcaaggaag catctgaact 120
gtaaatatcc aaagtcaagc tatggcttaa aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccccccaa atctatacag aaaaatatat taccgatgtt 240
ataatattgt actgaagtga gcatagcttg gttgatgttg ctccccaggg cgtaacagta 300
atatattgtt aatagattgt tatccttggc acaagccaga catatcatgt catggacgtc 360
tatttggact tttttcttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccatt cgttaagatc cgtatatttc tcatctagaa agcaaatggc 480
gttcttacaa acgtattgta ctgctttggc ataccaatac ttcactagta aatcatttaa 540
cttgtccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtataaca aatttgtttt ctaaaatagg attattcata aaaatttcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cctggtgaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ctatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc cacacgaagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattc ggccacgatc catacaaagc ttgagaggag catcatgcca 960
ccataggcca cagtatttca aaatgcagtg ttcatctatt gacaaacact ggctggctac 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 107
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 107
ctataatata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttttt cggggtcctt taagtttaat ggcaaggaag catctgaact 120
gtaaatatcc aaagtcaagc tatggcttaa aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgacgtt 240
ataatattgt actgaagtga gcatagcttg gttgatgttg ccccccaggg cgtaacagta 300
atatattgtt aatagattgt tatccttggc acaagccaga catatcatgt catggacgtc 360
tatttggact tttttcttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccact cgttaagatc cgtatatttc tcatctagaa agcaaatggc 480
gttcttacaa acgtattgta ctgctttggc ataccaatac ttcactagta aatcatttaa 540
ctcgtccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtataaca aatttgtttt ctaacatagg attattcata aaaatttcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cctggtgaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ctatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc cacacgaagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattc ggccacgatc catacaaagc ttgagaggag catcatgcca 960
ccataggcca cagtatttca aaatgcagtg ttcatctatt gacaaacact ggctggctac 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 108
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 108
ctataatata ttatgagaat attcccaaat gatggataag ttttttgatt tataatcttt 60
taataaactg cttatttttt cggggtcctt taagtttaat ggcaaggaag catctgaact 120
gtaaatatcc aaagtcaagc tatggcttaa aaaattataa cctttttgtt ccgctatggc 180
acgaccctct tcaaaggcat taccacccaa atctatacag aaaaatatat taccgacgtt 240
ataatattgt actgaagtga gcatagcttg gttgatgttg ccccccaggg cgtaacagta 300
atatattgtt aatagattgt tatccttggc acaagccaga catatcatgt catggacgtc 360
tatttggact tttttcttgt ggtacatctc atgaagctca tatattttgt tataatacag 420
gagacatttt aatcgccact cgttaagatc cgtatatttc tcatctagaa agcaaatggc 480
gttcttacaa acgtattgta ctgctttggc ataccaatac ttcactagta aatcatttaa 540
ctcgtccgtt tcttttattt ctatgagccc ccatagtctt ttataaatta agccccttaa 600
ttgtataaca aatttgtttt ctaacatagg attattcata aaaatttcat ggcacaaaat 660
aatactgccg ctggttttat tgtgcattat cctggtgaaa atacggaaaa tatcgttgtc 720
ctctagagtt tctttggcgc ctagctgtct acacaactct cggatgtgct tcgtattgat 780
agaaagcaaa ctatagttga tatttgcgcc ccactctgta aagagcttta tcagactata 840
gttgttttcc ttaacagcta ttattaatgc cacacgaagg tctatatctt ctcctaaaaa 900
tcctgatttt atttgtattc ggccacgatc catacaaagc ttgagaggag catcatgcca 960
ccataggcca caatatttca aaatgcagtg ttcatctatt gacaaacact ggctggctac 1020
cgtctttttg acgagggtct gcagagagag cggcaacgac at 1062
<210> 109
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 109
ttagagtata ttatgagagt aatccaaaat gatggataaa ttttttgatt tataattttt 60
taacaaactg cttatttctt cggggtcctt taagtttaat ggcaaggaag catccgagct 120
ataaatattc aaaaccaaac tatggcttag aaaattataa cctttttgtc tcgctatggc 180
actaccctct tcaaaggcat taccacccaa atctatacag aaatatatat taccgatgtt 240
ataatattgc actgaagtaa gcatagcttg gttgatgttg ccccccaggg cataacagta 300
atatattgtt aatggattgt tatccctgat acaagccagg gataacattt cattaacgtc 360
tatttggatt ttttccttgt ggtatatatc atgaagctca tatattttgt tataatatag 420
gtaacatttt aatcgccatt cattaagatc cgtatatttc tcatccagaa agcaaatggc 480
atctttataa tcgtattgta ctgctttggc gtaccaatat ttcactagta attcacttaa 540
ctcgtccgtt tcttttattt ctataagccc gcatagtctt ttataaatta agcgccttaa 600
ttgtgcagca aatttgtttt ctaaattagg attatttata aatatctcat ggcacaaaat 660
aacactgccg ctggttttat tatgcattat cttgttgaaa atacagaaaa tatcgtagtc 720
ctccagagtt tctttggcgc ctagctgtct acacaaatct cggacgtgct tcgtattgat 780
agaaagcaga ctatagttga tatttgcgcc caactctgta aaaagcttta ttagattata 840
gttgttttcc ttaacagcta ttattaatgc cacacaaagg tctatatctt ctcctaaaaa 900
tcccgatttt atttgtattc ggccacgatc catataaagc ttgagagggg catcatgcca 960
ccataagtca cagtatttca aaatgtgttc atctatcgac aaacatgatg tactggctac 1020
cgtctttttg acgagggttt gtagagagag cggcgccgac at 1062
<210> 110
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 110
ttagagtatt ttatgagagt aatccagaat gatggataaa ttttttgatt tataattttt 60
taataaactg cttatttctt cgggaacctt taagtttaat ggcaaggaag catctgagct 120
ataaatattc aaaattaaac tatggcataa aaaattataa ccattttgtc tcgctatggc 180
actaccctct tcaaaggcat taccacccaa atctatacag aaatatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg gttgatgttg ccccccaggg cataacaata 300
atatattgtt aatagattgt tatccctgat acaagccaga gataacattt cattgacgtc 360
tatttggatt tttttcttgt ggtatatatc atgaagctca tatattttgt tataacatag 420
gtaacatttt aatcgccatt catcaagatc cgtatatttt tcatccagaa agcaaatggc 480
atctttatga tcgtattgta ctgcattggc gtaccaatat ttcactagta attcgcttaa 540
ctcgtccgtt tcttttattt ctataagccc gcataatctt ttataaatta agcgccttaa 600
ttgtgcagca aagttgtttt ctaatttagg attatttata aatatctcat ggcacaaaat 660
aatactgccg ctagttttat tatgcattat tttattgaaa atacagaaaa tatcgtagtc 720
gtctagagtt tctttggcgc ctagctgtct acacaaatct cgggcgtgct tcgtattgat 780
agaaagcaga ctatagttga tatatgcgcc ccactctgta aataacttta tcagactata 840
gttattttcc ttaacagcta ttattaatgc cacacaaagg tctatatctt ctcctaggaa 900
tcccgatttt atgtatattc gtccacgatc tatgtaaagc ttgaggggag catcatgcca 960
ccataagcca cagtatttca aaatgtgttc atctatcgac aaacatgatg tactggctac 1020
cgtctttttg acgagggtct gcagagagag cggcgacgac at 1062
<210> 111
<211> 1062
<212> DNA
<213> African swine fever virus
<400> 111
ttagagtatt ttatgagagt aatccagaat gatggataaa ttttttgatt tataattttt 60
taataaactg cttatttctt cgggatcctt taagtttaat ggcaaggaag catctgagct 120
ataaatattc aaaaccaaac tatggcttaa aaaattataa ccattttgtc tcgctatggc 180
actaccctct tcaaaggcat taccacccaa atctatacag aaatatatat taccgatgtt 240
ataatattgt actgaagtaa gcatagcttg attgatgttg ccccccaggg cataacaata 300
atatattgtt aatagattgt tatccctgat acaagccaga gataacattt cattgacgtc 360
tatttggatt ttttccttgt ggtatatatc atgaagctca tatattttgt tataacatag 420
gtaacatttt aatcaccatt catcaagatc cgtatatttt tcatccagaa agcaaatggc 480
atctttatgg tcgtattgta ctgcattggc gtaccaatat ttcactagca attcgcttaa 540
ctcgtccgtt tcttttattt ctataagccc gcatagtctt ttataaatta agcgccttaa 600
ttgtgcagca aagttgtttt ctaaattagg attatttata aatatctcat ggcacaaaat 660
aatactgccg ctagttttat tatgcattat cttgttgaaa atacagaaaa tatcgtagtc 720
gtctagagtt tctttggcgc ctagctgtct acacaaatct cgggcgtgct tcgtattgat 780
agaaagcaga ctatagttga tatatgcgcc ccactctgta aataacttta tcatactata 840
gttgttttcc ttaacagcta ttattaatgc cacacaaagg tctatatctt ctcctaggaa 900
tcccgatttt atgtatattc gcccacgatc tatgtaaagc ttgaggggag catcatgcca 960
ccataagcca cagtatttca aaatgtgttc atctatcgac aaacatgatg taccggctac 1020
cgtctttttg acgagggtct gcagagagag cggcgacgac at 1062
<210> 112
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 112
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcagatt 60
ttttgaagta tatgtcttta gcatatcata tatttcctgg ggttcggtta catctaatac 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatga gttgtgccct atcaaaatcg gcagccccca aatcaataca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccccaac ctatgacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc tgatgcaaat ctctttttca cgacacaact cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttatagaaa tagtgaatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggtggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagc agaactcctg cacaggattt tagcctggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgttaagcc tcccagttcc gcacacagcc gctttagata 780
cacggcagga acacgtataa gcccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagttca agattatcgc tcttcacggc ctttactagc gccgcttcga gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaact tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 113
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 113
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcagatt 60
ttttgaagta tatgtcttta gcatatcata tatttcctgg ggttcggtta catctaatac 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatga gttgtgccct atcaaaatcg gcagccccca aatcaataca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccccaac ctatgacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc tgatgcaaat ctctttttca cgacacaact cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttatagaaa tagtgaatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggtggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagc agaactcctg cacaggattt tagcctggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgttaagcc tcccagttcc gcacacagcc gctttagata 780
cacggcagga acacgtataa gcccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagttca agattatcgc tcttcacggc ctttactagc gccgcttcga gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaact tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 114
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 114
ttagtctata actataattt ctggatgggc tgtaagatac tcttcagctc gtttcagatt 60
ttttgaagta tatgacttta gcatatcata tatttcctgg ggttcggtta catctaatgc 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatgc gttgtgccct atcaaaatca gtagccccca aatcgatgca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccctaac ctataacagt aataaatggc cgcataattt tttttctgca agcaagcaaa 360
tttcatcatc agattagggc tgatgcaaat ctctttttca cgacacaact cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttatagaaa tagtgaatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggtggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagc agaactcctg cacaggattt tagcctggcc acttctttta aaatttccag 720
aagacgggat tcggatacag gcgttaagcc acccagttcc gtgcacagcc gctttagatg 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta catgtttata cgaaaaaatt tgcttacaat tattacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caaccttttt ggccaatgtt tgtaaagaca acat 1074
<210> 115
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 115
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcagatt 60
ttttgaagta tatgacttta gcatatcata tatttcctgg ggttcggtta catctaatgc 120
caaggtcaca tcacggctga aaagctgctt tactaaaaaa atgttgctca agttatacat 180
ataagttttg tgcgcaatgc gttgtgccct atcaaaatca gtagccccca aatcgatgca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccctaac ctataacagt aataaatggc cgcataattt tttttccgca agcaagcaaa 360
tttcatcatc agattagggc tgatacaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttataaaaa tagtgaatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggtggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt tagcttggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgttaagcc tcccagttcc gtgcacagcc gctttagatg 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaatt tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacatataat catagtcact 1020
tgaaagataa ttgcatgcca caaccttttt ggccaacgtt tgtaaagaca acat 1074
<210> 116
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 116
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcatatt 60
ttttgaagta tatgccttta gcctatcata tatttcctgg ggttcggtta catctaatgc 120
caaggtcaca tcacggctga aaagctgctt tactaaaaga atgttgctca agttatacat 180
ataagctttg tgcgcaatgc gttgtgccct atcaaaatca gtagccccca aatcgatgca 240
gaaaaacagg tttaaagaat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agctcccaac ctataacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc taatgcaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttatagaaa tagtgaatag cctttgtaaa attatgtcgt aatgccagcg caaaccaaaa 540
ctttgttaat aggtggtgcg ccgtatcccc catcaacgga atttttgaac agctgtacat 600
aactgtgtct aaagtggttc tagttatggt ttccaagagt gggttataac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt taggttggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gtgttaagcc tcccagttct gtgcacagcc gctttagatg 780
cacggtagga acacatataa gtccatattc aggatttgca ccccaatcca caaataaacg 840
tataagctca agattatccc tcttcacggc ctttactagc gccgcttcaa gacagagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaatt tgcttacaat tgttacacag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacatataat catagtcact 1020
tgaaagataa ttgcatgcca caaccttttt ggccaacgtt tgtaaagaca acat 1074
<210> 117
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 117
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcagatt 60
ttttgaagta tatgacttta gcctatcata tatttcctgg ggttcggtta catctaatgc 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatgt gttgtgccct atcaaaatca gtagccccca aatcgatgca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccctaac ctataacagt aataaatggc cgcataattt tttttctgca agcaagcaaa 360
tttcatcatc agattagggc tgatgcaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagaggtgat ttttatgcct 480
tttatagaaa tagtgaatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggaggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt tagcttggcc acttctttta aaatttccag 720
aagacggggt tcggttacag gcgttaagcc tcccagttcc gtgcacagcc gctttagatg 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaatt tgcttacaat tgttacacag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caaccttttt ggccaacgtt tgtaaagaca acat 1074
<210> 118
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 118
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggccc gtttcatatt 60
ttttgaagta tatgtcttta gcatatcata tatttcctgg ggttcggtta catctaatac 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatga gttgtgccct atcaaaatcg gcagccccca aatcaataca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccccaac ctatgacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc taatgcaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagagctgat ttttatgcct 480
tttataaaaa tagtggatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggaggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt taggttggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgttaagcc tcccagttcc gcacacagcc gctttagata 780
cacggcagga acacgtataa gcccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagttca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaact tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 119
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 119
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcatatt 60
ttttgaagta tatgtcttta gcatatcata tatttcctgg ggttcggtta catctaatac 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatga gttgtgccct atcaaaatcg gcggccccca aatcaataca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccccaac ctatgacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc taatgcaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagagctgat ttttatgcct 480
tttataaaaa tagtggatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggaggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt taggttggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgtcaagcc tcccagttcc gcacacagcc gctttagata 780
cacggcagga acacgtataa gcccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagttca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaact tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 120
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 120
ttagtctata actataattt ctggatgggc tgtaagatac tcttcggctc gtttcatatt 60
ttttgaagta tatgtcttta gcatatcata tatttcctgg ggttcggtta catctaatac 120
caaggtcaca tcacggctga aaagctgctt tactaagaaa atgttgctca agttatacat 180
ataagctttg tgcgcaatga gttgtgccct atcaaaatcg gcggccccca aatcaataca 240
gaaaaacatg tttaaagtat tattgttata gatagaaaga ttcatgccat aatcgagact 300
agcccccaac ctatgacagt aataaatggc cgcgtaattt ttttcccgca agcaagcaaa 360
tttcatcatc agattagggc taatgcaaat ctctttttca cgacacagct cgtgtatgtc 420
aaaaatgtta ttaaaataaa ggctacaagc tacccgccaa tagagctgat ttttatgcct 480
tttataaaaa tagtggatag cctttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgttaat aggaggtgcg ccgtatcccc cgtcaacgga atgtttgaac aggtgtacgt 600
aactgtgtct aaagtggttc tagttacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt taggttggcc acttctttta aaatttccag 720
aagacggggt tcggatacag gcgtcaagcc tcccagttcc gcacacagcc gctttagata 780
cacggcagga acacgtataa gcccatattc aggatttgcg ccccaatcca caaataaacg 840
tataagttca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata cgaaaaaact tgcttacaat tgttacatag 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc aacgtataat catagtcact 1020
tgaaagataa ttgcatgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 121
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 121
ttagtctata actacaattt ctggatgggc tgtaaaatac tcttcggctt gttttagatt 60
ttttgacgta tatgtattta gcatatcata tattgcctgg ggctcagtta gatctaatat 120
caagctcaca tcacggctga aaagctgttt tactaaaaaa aggttgctca agttatacat 180
ataaactcta cgcgcaatga gtcgcgccct atcaaagtta gtagccccca aatcaatgca 240
gaaaaatagg tttaaagtat tattgttata gatagataga ttcatgccat aatcaagact 300
agcccctaac atatgacagt aataaatggc tgcataattt tcttcccgca agcaagcaaa 360
tttcatcatc agattagggc taatgcaaat ctctttttta caacacagct catgcaagtc 420
aaaaatgttg ttaaaataaa ggctacaagt cagtcgccaa tagagctgat ttttatgctt 480
ttcgtagaaa tagtgaatag cttttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
ctttgataat aggaggtgcg ccgtatcccc cgtcaacgga atttttgaac gggtgtacat 600
aactgtgtct aaggtggttc tagtcacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt cagatcggcc acttctttta aaatctccag 720
aagacgagat tcggatacag gtgttaagcc tcctagttcc atgcacagcc gctttagatg 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaacaatcg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcttcaa gacaaagatc 900
atcctcagaa aaacactgta aatgtttata tgaaaaaatt tgcttacatg tattacataa 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc agcgtataat cataatcact 1020
tgaaagataa ttgcatgcca caactttttt ggccagcgtt tgtaaagaca acat 1074
<210> 122
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 122
ttagtctata actacaattt ctggatgggc tgtaaaatac tcttcggctc gttttagatt 60
ttttgacgta tatgtcttta gcatatcata tattgcctgg ggttcggtta tatttaatac 120
caagctcgca tcacggctga aaagctgttt tactaaaaaa atgttgctca agttatacat 180
ataaactcta tgcgcaatga gtcgcgctct atcaaagtta gtagccccca aatcaataca 240
gaaaaatagg tttaaagtat tattgttata gatagataga ttcatgccat aatcgggact 300
agcccccaac atatgacagt aataaatggc tgcataattt tcttcccgca ggcaagcaaa 360
tttcatcatt agattagggc taatgcaaat ctctttttta gaacacagct catgcaagtc 420
aaaaatatta ttaaaataaa ggctacaagc cagccgccaa tagagctgat ttttatgctt 480
ttcatagaaa tagtgaatcg cttttgtaaa attatgtcgt aatgccaggg caaaccaaaa 540
cttcgttaat aggaggtgcg ccgtatcccc cgtcaacgga atttttgaac gggtgtacat 600
aacggtgttt aaagtggttc tagtcacggt ttccaagagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt cagatcggcc acttctttta aaatttccag 720
aagacgagat tcggagacag gtgttaagcc tcctagttct gtgcacagcc gttttagatc 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaacaatcg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcgtcaa gacaaagatc 900
atcctcagaa aaacactgca aatgttgata cgaaaaaatt tgcttacatg tattacataa 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc agcgtataat catagtcact 1020
tgaaagataa ttgcatgcca caaccttttt ggccaacgtt tgtaaagaca acat 1074
<210> 123
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 123
ttagtctata acgacaattt ctggatgggc tgtaaaatac tcttcggctc gttttagatt 60
ttttgacgta tatgtcttta gcatatcata tattgcctgg ggttcggtta tatttaatac 120
caagctcgca tcacggctga aaagctgttt tactaaaaaa atgttgctca agttatacat 180
ataaactcta tgcgcaatga gtcgcgctct atcaaagtta gtagccccca aatcaatgca 240
gaaaaatagg tttaaagtat tattgttata gatagataga ttcatgccat aatcgggact 300
agcccccaac atatgacagt aataaatggc tgcataattt tcttcccgca ggcaagcaaa 360
tttcatcatt agattagggc taatgcaaat ctctttttta gaacacagct catgcaagtc 420
aaaaatgtta ttaaaataaa ggctacaagt tagccgccaa tacagctgat ttttatgttt 480
ttcgtagaaa tagtgaatcg cttttgtaaa attatgccgt aatgccaggg caaaccaaaa 540
cttcgttaat aggaggtgcg ccgtatcccc cgtcaacgga atttttgaac gggtatacat 600
aactgtgttt aaagtggttc tagtcacggt ttccataagt ggattatgac aaaacatgtc 660
ataacccagt agaactcctg cacaggattt cagatcggcc acttctttta aaatttccag 720
aagacgagat tcggagacag gtgttaagcc tcctagttcc gtgcacagcc gttttagatg 780
cacggcagga acacgtataa gtccatattc aggatttgcg ccccaatcca caaacaatcg 840
tataagctca agattatcgc tcttcacggc ctttactagc gccgcgtcaa gacaaagatc 900
atccacagaa aaacactgca aatgttgata cgaaaaaatt tgcttacatg tattacataa 960
gtgaatagga cctaaatccc accacaaacc aaaacgctgc agcgtataat catagtcact 1020
tgaaagataa ttgcacgcca caactttttt ggccaacgtt tgtaaagaca acat 1074
<210> 124
<211> 1071
<212> DNA
<213> African swine fever virus
<400> 124
atgtctactc cactttctct acagactctt gttaaaaaag tgctggccac acagcacata 60
tctaaagaac actactttat tttgaaatat tgtggtttat ggtggcatga agcgccgatt 120
acgatttgca ttgatgagga tagccaaata ttgataaaat cggcaagctt caaagaaggc 180
ttatctttag atatcgcatt aatgaaagtc gtgcaagaaa ataaccatga tttaatagag 240
ttgtttacca agtggggtgc agatatcaac tctagcttag ttactgttaa tacggagtat 300
acccggaacc tttgtcagaa attaggcgca aaggaagctt tgaatgaaag ggatatttta 360
caaatatttt ataaaacacg tcatcttaaa actagcagta atattatttt atataatgaa 420
ttgttttcta ataatctcct tttccaaaat atagagagat tgagtttaat agtttatagg 480
ggcttgaaaa acttatcaat caactttata ttggatgata tttcatttag cgaaatgtta 540
actagatact ggtatagtat ggcgatatta tataacctta ctgaagccat ccaatatttt 600
tatcaacgat ataggcattt taaagattgg cggcttatat gtgggctttc ttttaacaat 660
ttgtctgacc ttcatgaagt atataactta gagaagacgg atatagacat tgatgaaatg 720
atgaagttga cctgtagtac gtatgatggt aattattcga ctatttatta ttgttttatg 780
ttgggggctg acatcaatcg ggcaatgtta acctcggtaa taaactttca tattggtaac 840
ttgttccttt gtatagattt aggagctgat gctttcgaag acagcatgga actagcaaaa 900
caaaagaata ataatatatt agtagaaata ttatcattta aaaattatta tagttcaaat 960
acctctcttt tatcaataaa aacgacagat ccggaaaaaa ttaatgcctt attagatgaa 1020
gaaaagtatg agtcaaaaaa tatgttaatg tatgaagaat tatctcattg a 1071
<210> 125
<211> 1071
<212> DNA
<213> African swine fever virus
<400> 125
atgtctactc cactttctct acagactctt gttaaaaaag tgctggccac acagcacata 60
tctaaagaac actactttat tttgaaatat tgtggtttat ggtggcatga agcgccgatt 120
acgatttgca ttgatgagga tagccaaata ttgataaaat cggcaagctt caaagaaggc 180
ttatctttag atatcgcatt aatgaaagtc gtgcaagaaa ataaccatga tttaatagag 240
ttgtttacca agtggggtgc agatatcaac tctagcttag ttactgttaa tacggagtat 300
acccggaacc tttgtcagaa attaggcgca aaggaagctt tgaatgaaag ggatatttta 360
caaatatttt ataaaacacg tcatcttaaa actagcagta atattatttt atataatgaa 420
ttgttttcta ataatctcct tttccaaaat atagagagat tgagtttaat agtttatagg 480
ggcttgaaaa acttatcaat caactttata ttggatgata tttcatttag cgaaatgtta 540
actagatact ggtatagtat ggcgatatta tataacctta ctgaagccat ccaatatttt 600
tatcaacgat ataggcattt taaagattgg cggcttatat gtgggctttc ttttaacaat 660
ttgtctgacc ttcatgaagt atataactta gagaagacgg atatagacat tgatgaaatg 720
atgaagttga cctgtagtac gtatgatggt aattattcga ctatttatta ttgttttatg 780
ttgggggctg acatcaatcg ggcaatgtta acctcggtaa taaactttca tattggtaac 840
ttgttccttt gtatagattt aggagctgat gctttcgaag acagcatgga actagcaaaa 900
caaaagaata ataatatatt agtagaaata ttatcattta aaaattatta tagttcaaat 960
acctctcttt tatcaataaa aacgacagat ccggaaaaaa ttaatgcctt attagatgaa 1020
gaaaagtatg agtcaaaaaa tatgttaatg tatgaagaat tatctcattg a 1071
<210> 126
<211> 1065
<212> DNA
<213> African swine fever virus
<400> 126
atgtctactc cactttctct acagactctt gttaaaaaag tgctggccac acagcacgta 60
tctaaagatc actactttat tttaaaatat tgtggtttgt ggtggcataa ggccccgatt 120
acgatttgca ttgatgagga tagccaaata ttgataaaat cggcaagctt taaagaaggc 180
ttacctttag atatggcatt aatgaaagct gtacaggaaa acaactatga aatgatcatg 240
ttgtttactg agtggggtgc agacattaac tctagcttag tcactgttaa tacggagcgt 300
acccggaacc tttgtcgaga attaggcgcg aaggaaattt tgaatgaaaa agaaatttta 360
gaaatatttt ataaaacatg tcatattaaa actagcagta attttattct atgccatgaa 420
ttgttatcca ataatcccct tttccaaaat atagagagtt tgagtttaat agtttatagg 480
ggcttgaaaa acttatcaat taactttata ttggatgata tttcatttag cgaaatgtta 540
actagatact ggtatagctg ggcgatatta tataacctta ctgaagctat tcaatatttc 600
tatcaaacat acaagcattt taaagattgg cggctaatat gtggacttgc ttataataac 660
gtgtttgatc ttcatgaaat ttataacata gaaaagactg atttagatat tgatgaaatg 720
atgcagttgg cttgtatgta tgatagtaat tattcaacta tttattattg ttttatgttg 780
ggggctaata tcaatcaggc aatgttaacc tcggtaataa accattatat taataacttg 840
ttcctttgta tagatttggg agctgacgcc gtcaaagaca gcatggaact agcaaaacaa 900
aagaattata atatattagt aaaaatatta acatttaaaa attatagtcc agactcttct 960
cttttatcat taaaaacgac agatccggaa aaaattaatg ccttactaga tgaagaaaag 1020
tatgagtcga aaaatatgtt aatgtatgaa gaatcatctc gttga 1065
<210> 127
<211> 1052
<212> DNA
<213> African swine fever virus
<400> 127
atgccttctc cacattctct acagactctt gctaaaaaaa tactggctac acagcagata 60
tctacagatc actactttat tttaaaatat tgtggtttat ggtggcatgg agctccaatt 120
atgctttcta ctaatgagga taatcaattg atgataaaat cggcaagctt caaagaaggc 180
ttatctttag atttggcatt aatgaaagtc gtgcaagaaa acaatcatga tttaataaag 240
ctgtttaccg agtggggtgc agacatcaac tctagcttcg tcactgttaa tatggagtgt 300
acccgaaacc tctgtcggga attaggcgcg aaggaagctt tgaatgaaag ggatatttta 360
caaatatttt ataaaacacg tgatattaaa actagcagtc atgttatttt atgccatgaa 420
ttattatcca ataaccccct tttccagaat atagagagaa tgcgttcaat aatttatagg 480
agtctggaaa aactatcaat caactttata ttggatgata tttcatttag tgaaatgtta 540
actagacact ggtatgggtt ggcgatatta tataacctaa ctgaagctat ccaatatttc 600
tatgaaaaat acaagcattt taaaaattgg cggctaatat gtggactttc ttttaacaat 660
ctgtctgatc tttatgaaat atataattta gagaaggttg atatgaacat tgatgaaatg 720
atgtatctgg cctgtagtat atatgatggt aattattcaa ctatttatta ttgttttgta 780
ttgggagctg atatcaatca ggcaatgtta acctcagtaa taaaccattg tattggtaac 840
ttgttccttt gtatagattt aggggctgat gctttcgaag acagcatgga actagcaaag 900
caaaaaaatg ataatatttt tattagtata ttatcattta aaaattacag tccagactct 960
tctcttttgt cattaaaaat gacagatccg gaaaaaatta atgccttact agatgaagaa 1020
aagtatgagt caaaaaatat gttaatgttt ga 1052
<210> 128
<211> 1086
<212> DNA
<213> African swine fever virus
<400> 128
atgcctactc cactttctct acagactctt gctaaaaaag tactggccac acagtatata 60
tccatagatt attactttat tttgaaatat tgtggtttat ggtggcatgg agcccctatt 120
atgatttcca ttgataagaa taaaagccaa atactgataa aatcggcaag cttcaaagaa 180
ggcttatctt tagatatcgc attaatgaaa gctgtgcagg aaaacaatca tgatttaata 240
aagctgttta ccgagtgggg tgcagacatc aactctagct tagtcactgt taatacggag 300
tgtacccgaa acctctgtcg ggaattaggc gcgaaggaag ctttgaatga aagggatatt 360
ttacaaatat tttataaaac acgtgatatt aaaactagca gtaatgttat actatgccat 420
gaattgttat ccaataaccc ccttttccaa aatatagaga gaatgcgttc aataatttat 480
aggagtctgg aaaaactatc aattaacttt atattggatg atatttcatt tagcgaaatg 540
ttaactagac actggtatag gttggcgata ttatataacc taactgaagc tatccaatat 600
ttctatgaaa aatacaagca ttttaaagat tggcggctaa tatgtgggct ttcttttaac 660
aatctgtctg accttcatga aatatataac ttagagaagg ttgatatgga cattgatata 720
atgatgtatc tggcctgtag tacgtatgat ggtaattatt caactattta ttattgtttt 780
gtattggggg ctgatatcaa tcaggcaatg ttaacctcgg taataaacca tcgtattggt 840
aacttgttcc tttgtataga tttaggggct gatgccttcg aagacagtat gaaactagca 900
aaacaaaaga atcataatat attagtacat atattatcgt ttaaaaacta tagtccagac 960
ttctcccttt tatcaataaa aacgacagat ccagagaaaa ttaatgcctt actagatgaa 1020
gaaaagtatg agtcaaaaaa tatgttaatg tatgatgaat ttgacgcctg tactaataat 1080
gtttaa 1086
<210> 129
<211> 1086
<212> DNA
<213> African swine fever virus
<400> 129
atgcctactc cactttctct acagactctt gctaaaaaag tactggccac acagtatata 60
tccatagatt attactttat tttgaaatat tgtggtttat ggtggcatgg agcccctatt 120
atgatttcca ttgataagaa taaaagccaa atactgataa aatcggcaag cttcaaagaa 180
ggcttatctt tagatatcgc attaatgaaa gctgtgcagg aaaacaatca tgatttaata 240
aagctgttta ccgagtgggg tgcagacatc aactctagct tagtcactgt taatacggag 300
tgtacccgaa acctctgtcg ggaattaggc gcgaaggaag ctttgaatga aagggatatt 360
ttacaaatat tttataaaac acgtgatatt aaaactagca gtaatgttat actatgccat 420
gaattgttat ccaataaccc ccttttccaa aatatagaga gaatgcgttc aataatttat 480
aggagtctgg aaaaactatc aattaacttt atattggatg atatttcatt tagcgaaatg 540
ttaactagac actggtatag gttggcgata ttatataacc taactgaagc tatccaatat 600
ttctatgaaa aatacaagca ttttaaagat tggcggctaa tatgtgggct ttcttttaac 660
aatctgtctg accttcatga aatatataac ttagagaagg ttgatatgga cattgatata 720
atgatgtatc tggcctgtag tacgtatgat ggtaattatt caactattta ttattgtttt 780
gtattggggg ctgatatcaa tcaggcaatg ttaacctcgg taataaacca tcgtattggt 840
aacttgttcc tttgtataga tttaggggct gatgccttcg aagacagtat gaaactagca 900
aaacaaaaga atcataatat attagtacat atattatcgt ttaaaaacta tagtccagac 960
ttctcccttt tatcaataaa aacgacagat ccagagaaaa ttaatgcctt actagatgaa 1020
gaaaagtatg agtcaaaaaa tatgttaatg tatgatgaat ttgacgcctg tactaataat 1080
gtttaa 1086
<210> 130
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 130
atgcctacac cgtcttcttt acaagtcctt gtcaaaaggg tgttggacta ccagcatcat 60
gtatctgaag atgattattg tattttacag cattgtgggt tgtggtggca tggaagtcca 120
attatgtttt ttactaatga aaatcatcaa aggatgataa aatcagcaag ctttaaagat 180
ggtttagaaa taaatctcgc attaatgaag gccgtacagg aaaacaattg tatcttaata 240
gagctgttta ccgaatgggg tgcagacatt aattatggat tgattactgt caatacggaa 300
tatacccgaa acctatgtcg aaatctaggt gccaaggagg cgttaaatac acggaaaatt 360
ttagatgtat ttttaaattt aaaggatttt aaaagtagta atcatattat tctatgccat 420
gaattgttat ctaataatcc tcttttacta agtgaaaata atgattattt gagaaaaata 480
attaattgta atctaaggag aatatcaatt aactttatat tggatgaaat ttcatttaat 540
gaaaagctaa ccagattctg gtataaacag gcagtactaa ataatcttac tgaagctatc 600
caatatttct atcaaaaata taagcagttt aaagactggc gactaatatg tggacttgct 660
ttaaataatg tatttgatct tcatgaaata tataacaaag agaaggctga tatagatatt 720
aatcaaatga tagagataac ctgtacatat atgtgtagtt atcccaccat ttactattgt 780
tttgtaatgg gggctgacat taatcgggca atgattacct cagttacaaa atcttatact 840
ggtaacttgt tcttttgtat agatttagga gctactgcct tcgaagagtg cttagaaata 900
gcaaaacaac agaatgataa tgaattggta aaggtattat cattgaaaaa ctattacagt 960
ccagatagct cccttttatc attaaaaata acagatccgg aaaaaattaa tatcttatta 1020
gatgatgaaa catatgagtc aaaaaatgag ttaatatatg aagaattaat ataa 1074
<210> 131
<211> 1095
<212> DNA
<213> African swine fever virus
<400> 131
atgtccacac catcttcttt acaagtcctt gtcaaaaggg tgctggactt ccagcatgtg 60
tctgaagatg attactgtat tttaaaatgt tgtgggttat ggtggcatgg aggcccaatc 120
atgctttcta cgaatgagga taatcaaatg atgataaaat cagcaagttt taaagatggt 180
ttagagataa atctcgcatt aatgatggcc gtacaagaaa acaattgtag cctaatagag 240
ctgtttaccg aatggggtgc agacattaat tctggattgg ttactgtcaa cacggaatac 300
acccgaaacc tatgtcgaaa tctaggtgct aaggagacat taaataaacg ggaaatttta 360
gatgtatttt taaaattaaa gaattttaaa agtagtaata atattattct atcccatgaa 420
ttattatcta ataatcctct tttcctaagt gaagataatg attattttag aagaataatt 480
aattgtaatc taaggagaat atcaattaac tttatattgg atgaaatttc atttaatgaa 540
aagctaacca gattctggta tagtcaggcg gtactatata atcttactga agctatccaa 600
tatttctatc aaaaatatga acatctcaat gagtggcgtt taatttgtgc gctttctttt 660
aataatgtgt ttgatcttca tgaaatatat aacaaagaaa aggttggtat ggatattaat 720
caaatgatag agataacctg tgcatatatg tgtagttatt ccaccattta ctattgtttt 780
gtaatgggag ctgacattaa tcgggcaatg attatctcgg ttacaaaatc ttatacttat 840
aacttgttct tttgtataga tttaggagct actgccttcg aagagtgttt agaaatagca 900
aaacaacaga ataataatga attagtaaaa atattatcat tgaaaaacta ttatagtcca 960
gatagctccc ttatatcatt aaaaataaca gatccggaga aaattaatat cttattagat 1020
gaggaaaatt atgagtcaaa aaatgagtta atatatgaag aatctaatat aaataatagc 1080
gatgatatat tttga 1095
<210> 132
<211> 1071
<212> DNA
<213> African swine fever virus
<400> 132
atgccatcta ctttacaagc acttgctaaa aaagtactgg ccacaccgca tatatctaaa 60
aaatattgtc agtctaagga gtactgtcat atattaaaat gttgtggttt atggtggcat 120
gatgctccaa ttacaattta tccttgtata aataaaatat tgataaaaac agcaagcttt 180
aaacatggtt tagagttgaa tgtcgcattc atgaaagctg tacaggaaaa taattatgat 240
ctaataaggc tgtttattga gtggggtgcg gatatcaact ttgggttggc cactgttaat 300
acagaccgta cccgggacct gtgccgggaa ctaggtgcga aggaagcttt aagtgaaaaa 360
gaaattttag aaatatttga taaaatacag tatattaaaa gtagcagtaa tattattgta 420
tcccatgaat tattatctaa taaccccctt ttcttaaata atgatcaatt gaaattaaga 480
atgttcgatg aactacataa actatcaatc aactttgtat tacatgagat atcatttaat 540
gaaatgctaa ctaggtattg gtatagtatg gcgatactat ataacctcac cgcagccatt 600
caatattttt atcaatccta caagcatttt aaagattggc ggttaatatg tgggcttgct 660
tataacaacg tgtttgatct tcatgaaata tataacaaag agaaggttga tatggatatt 720
aatcaaatga tgcagttggc ctgtatgtat gatggtaatt atacaaccat ttattattgt 780
tttatgttgg gagctgacat taatcgggca atgattacct cggttacaaa atcttgtgat 840
ggtaacttat tcctttgtat agatttgggg gctgatgtat ttgaagagag tatgaaaatg 900
gcaatagaag atcataatga cgtattagaa agtatcttat catttaaaaa ttattatagt 960
tcagacgttt ctctgttatc attaaagacg acagatccag aaaaaattaa tgccttgtta 1020
gaagaagaaa gttacaaatc aaaaaatagg ttgatatata aaagttattg a 1071
<210> 133
<211> 1074
<212> DNA
<213> African swine fever virus
<400> 133
atgatgccat ctactttaca aacacttgct aaaaaaacat tggccacaca gcatatatct 60
aaaaaatatt ggccgtctga ggagtattgt tatatattaa aatgttgtgg tttatggtgg 120
catgattctc caatcacgat ttttacttgt ataaaacaaa tattaataaa aacagcaaac 180
tttaaacatg gtttagactt aaaccttgca ttaatgaaag ctgtacaaga aaataactat 240
gaattgatca tgttgtttac tgagtggggt gcggatatca acttggggtt gatcactgtt 300
aatacagagt gcacccgaga tttgtgccaa aagttaggtg caaaggaagc tttgagtgca 360
aaggaaattt tagaaatatt ttataaaata cagtatatta agagtagcaa taatattatt 420
atatctcatg aattaatatc taatcatccc cttttcctaa ataatgatca attgaaatta 480
agaattgttg gtgaactaaa tgctatatca atcaacttta tattggatga gatatcattc 540
aatgaaatgc taactaggta ttggtatagt atggcgatac tatataaact ccctgcagcc 600
attcaatatt tttatcaatc atacaagtat tttaaagatt ggcggttaat atgtagcctt 660
gcttataaca acgtgtttga ccttcatgaa atttataata aagagaagac tgatataaac 720
attgatgaaa tgatgcggtt ggcctgtagg tatgatggta attatacaac tatttattat 780
tgttttatgt tgggggctga cattaatcag gcaatgatta cctcggtcat gaatctttgg 840
gacggtaact tatttctttg tatagatttg ggggctgatg tatttgaaga gtgtatgaaa 900
atagcaatag aagatcataa tggtgtatta gaaagtatct tatcatttaa aaattattat 960
agtccagacg tttctctgtt atcattaaaa acgacagatc cggaaaaaat taatgacttg 1020
ctagatgaag atatctataa atcaaaaaat aggttgatat ataaaagttg ttga 1074
<210> 134
<211> 1596
<212> DNA
<213> African swine fever virus
<400> 134
atgttctctc tccagaactt atgtcgaaaa acattaccta accgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatacag caacataccc tcattcccgt aaatgaagcc 180
ctgagaacag cagcatctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagtc 360
atatttcaca aatgccatat catgcggcaa tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tactttaaac atagattaga ggatgatttg 480
cccttcactc atttacttat tgaaaaggca tgtaaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tatctacaat atgatagata cctttgaatg tgctattgcc 600
cataaggatc tacatctata ttgtttgggg tatagattta tatataacag aatcgtaccc 660
gataagtatc atcatttaga tattcgcatg ctttcaagcc tacaactcct acataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taataaagat 780
aatataaata ttattctaac acaagctgca acctataacc atagaaaaat tttaatctat 840
ttcattcctc aatcaaccca cgcacagata gaacaatgtt tactagtggc gataaaagca 900
aaatcttcca ggaaaacctt gaacttacta ctgtctcacc taaacctttc catcaacctc 960
atcaaaaaaa taagccatta tgttgccact tacaattcaa caaatataat aggcattctg 1020
agtatgcggc ggaaaaagaa gatatattta gatatcatat tgacaaaatt tgtaaaaaaa 1080
gctattttta ataagtttgt cgttcgatgt atggatacat tttctataaa cccggaaaga 1140
atccttaaaa tagccgcgcg aataaatagg atgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggt tagacttaaa taccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg atcgctgtta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ccaatatcaa catcgtgaac 1500
aagtatatcg gcaacctgtt tgttatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tttattctaa acaatacatg ccttag 1596
<210> 135
<211> 1596
<212> DNA
<213> African swine fever virus
<400> 135
atgttctctc tccagaactt atgtcgaaaa acattaccta accgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatacag caacataccc tcattcccgt aaatgaagcc 180
ctgagaacag cagcatctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagtc 360
atatttcaca aatgccatat catgcggcaa tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tactttaaac atagattaga ggatgatttg 480
cccttcactc atttacttat tgaaaaggca tgtaaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tatctacaat atgatagata cctttgaatg tgctattgcc 600
cataaggatc tacatctata ttgtttgggg tatagattta tatataacag aatcgtaccc 660
gataagtatc atcatttaga tattcgcatg ctttcaagcc tacaactcct acataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taataaagat 780
aatataaata ttattctaac acaagctgca acctataacc atagaaaaat tttaatctat 840
ttcattcctc aatcaaccca cgcacagata gaacaatgtt tactagtggc gataaaagca 900
aaatcttcca ggaaaacctt gaacttacta ctgtctcacc taaacctttc catcaacctc 960
atcaaaaaaa taagccatta tgttgccact tacaattcaa caaatataat aggcattctg 1020
agtatgcggc ggaaaaagaa gatatattta gatatcatat tgacaaaatt tgtaaaaaaa 1080
gctattttta ataagtttgt cgttcgatgt atggatacat tttctataaa cccggaaaga 1140
atccttaaaa tagccgcgcg aataaatagg atgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggt tagacttaaa taccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg atcgctgtta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ccaatatcaa catcgtgaac 1500
aagtatatcg gcaacctgtt tgttatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tttattctaa acaatacatg ccttag 1596
<210> 136
<211> 1596
<212> DNA
<213> African swine fever virus
<400> 136
atgttctctc ttcagaacct atgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatacag caacataacc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtga gtcttttatt agcatgggag 240
gggaaccttt actatgctat tataggggct ctagagggca accgccacga cttaattcgt 300
aagtatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagta 360
atatttcaca aatgccatat catgcggcaa tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tcttttaaac atagattaag ggatgatttg 480
cccttcactc atttacttat tgaaaaggca tgtaaagatc ataattatga agtaattaaa 540
tggatatatg aaaacctaca tatctacaat atgatagata cctttgaatg tgctattgcc 600
cataaggatc tacgtctata ttgtttgggg tatagattta tatataacag gatcgtaccc 660
gataagtatc atcatttaga tattcgcatg ctttcaagcc tacaactcct gcataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taataaagat 780
aatataaata ttattctaac acaagctgca acctataacc atagaaaaat tttaatctat 840
ttcattcctc aatcaaccca cgcacagata gaacaatgtt tactagtggc gataaaaaca 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaacctttc catcaatctc 960
atcaaaaaaa taagccatta tgttgccact tacaattcaa caaatataat aggcattctg 1020
agtatgcggc ggaaaaagaa gatatattta gatatcatat tgacaaaatt tgtaaaaaaa 1080
gctattttta ataaatttgt cgttcgatgt atggatacat tttctataaa cccggaaaga 1140
atccttaaaa tagccgcgcg aataaatagg acgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggt tagacttaaa taccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg atcgctgtta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ccaatatcaa catcgtgaac 1500
aagtatatcg gcaacctgtt tgttatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattacatg ccttag 1596
<210> 137
<211> 1596
<212> DNA
<213> African swine fever virus
<400> 137
atgttctctc tccagaacct atgtcgaaaa actttacctg actgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatacag caacgtaccc tcattcccgt aaatgaagcc 180
ctgagaatag cagcatctga agaaaattat gagatcgtgg gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggagct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagtc 360
atatttcaca aatgccatat aatccgacga tgctttttta attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tactttaaac atagattaga ggatgatttg 480
cccctcactc atttacttat tgaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tacctacgat ataatggata cctttgaatg tgctattgcc 600
cataaggatc tacgtctata ttgtttgggg tatacattta tatataacag gatcgtaccc 660
tatgagtatc atcatttaga tattctcatt ctttcaagcc tacaactcct gcataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taacaatgat 780
aatttagata ttattctaac acaagctgca acatataacc atagaaaaat tttaacctat 840
ttcattcctc aattaaccta cgcacaaata gaacaatgtt tgttcatggc gataaaaaga 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaccctttc catcgaactc 960
atcaaaaaaa taagccaata tgttgtcact tacaattcaa caaatataat aggcattctg 1020
agtatgaagc ggaaaaagaa gatatattta gatatcatgt tgacaaaata tgtaaaatac 1080
gctattttta ataaatatgt cgttcgatgt atggatagat tttccataaa cccggaaaga 1140
atcatcaaaa tggccgcgcg aataaatagg atgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggc tagacttaaa caccttaagc atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg atcgctgcta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtatccta gatactatac aattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ccaatatcaa catcgtgaac 1500
aagtatattg gcgacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattacatg ctttag 1596
<210> 138
<211> 1596
<212> DNA
<213> African swine fever virus
<400> 138
atgttctctc tccagaactt atgtcgaaaa acattacctg attgtaaact tcctgaattt 60
tttgacgatt atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgggcaggaa acaactgtgt gcttatacag caacataccc ttattcccat aaatgaagcc 180
ctgagaacag cagcatctga agaaaattat gagatcgtga gccttttatt agcatgggag 240
gggaatcttt actatgctat tataggggct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagta 360
atatttcaca aatgccatat catgcggcga tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tattttaaat ataggttaga ggatgattta 480
cccctcactc atttacttat tgaaaaggca tgtgaaaatc ataattatga agttattaga 540
tggatatatg aaaacctaca tatctacaat atgatagata cctttgaatg tgctattgcc 600
cataaggatc tacgtctata ttgtttgggg tatacattta tatataacag gatcgtaccc 660
aataagtatc atcatataga tattctcatt ctttcaagcc tacaactcct gcataaggtg 720
gcagccaaag gatacttaga ctttatccta gaaaccttaa agtatgatca taacaatgat 780
aatttagata ttattctaac acaagctgca acatataacc atagaaaaat tttaacctat 840
tttattcctc aatcaaccta cgcacaaata gaacaatgtt tgatggtggc gataaaaaca 900
aaatcttcca agaaaacctt gaatttacta ttgtcccacc taaacctttc catcaaactc 960
atcaaaaaaa taagccaata tgttgtcact tacaattcaa caaatataat aggcattctg 1020
agtatgaagc gaaaaaagaa gatatattta gatatcttgt tgacaaaatt tgtaaaaaat 1080
gctattttta ataaatttgt cgttcgatat atggatacgt tttctataaa cccggaaaaa 1140
atcgtcaaaa tggccgcgcg aataaataag atgatgttag tgaaaaaaat atctgaacat 1200
atttggaaaa atcatgcggc tagacttgaa caccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg agtactgcta ttaccatatg 1320
caaggggaag aaatttttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
ttcgacgttt tttataattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ctaatatcaa catcgtgaac 1500
aagtatattg acaacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tttattctaa acattatatg ccttag 1596
<210> 139
<211> 1596
<212> DNA
<213> African swine fever virus
<400> 139
atgttttctc tccagaactt gtgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatacag caacataccc tcattcccgt aaacgaagcc 180
ctgagaatag cagcatctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
ggaaaccttt actatgctat tataggagct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga cgatccagtc 360
atatttcaca aatgccatat catgcggcga tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tattttaaat ataggttaga gaatgatttg 480
cccctcgctc atttacttat taaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tatctacaat ataatggata cctttggatg tgctattgcc 600
cataaggatc tacgtctata tcgtttgggg tatacattta tatataacag gatcgtaccc 660
tataagtatc attatttaga tgttctcatt ctttcaggcc tacatctcct gtataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taacaatgat 780
aatttagata ttattctaac acaagctgca acatataacc atagaaaaat tttaacctat 840
tacattcctc aattaaccta tgcacaaata gaacaatgtt tgttcatggc gattaaaaaa 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaagctttc catcaaactc 960
atcaaaaaaa taagccaata tgttgccact tacaattcaa caaatataat aggcattctg 1020
aatatgcggc ggaaaaagaa gatatattta gatatcatat tgacaaaatt tgtaaaaaaa 1080
gctattttta ataaatttgt cgttcgatgt atggatacat tttccataaa cccggaaaga 1140
atcatcaaaa tggccgcgcg aataaataag atgttgttag tgaaaaaaat atctgaacat 1200
gcttggaaaa atcatgcggc tagacttaaa caccttaagc atgcggtata cacgatgaaa 1260
cataaagatg ggaaaaatag actcatgaac ttgatctatg atcactacta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtctccta gatactatac gatttaaaaa ccttctttta 1440
gattgttcac acatcatagg taaaaacgct catgatgcta ctaatatcac tatcgtgaac 1500
aagtatattg gcaacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattacatg ccttag 1596
<210> 140
<211> 1596
<212> DNA
<213> African swine fever virus
<400> 140
atgttctctc tccagaactt atgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgatt atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgggcaggaa acaactgtgt gcttatacaa caacataccc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtgg gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggta accgctacaa cttaattcgt 300
aaatatgatg atcaaatcaa ggaccatcat gacattctgc cattcattga tgatccaatc 360
atatttcaca aatgccatat catgcggcga tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg tgttcttctt tattttaaat atacattaga ggatgatttg 480
cccctcgttc atttacttat tgaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tgtctgccat ataatagata cctttgactg tgctattgcc 600
cataaagatc tacgtttata ttgtttgggg tatacattta tatacaacag gattgtaccc 660
tataagtatc atcatttaga tattctcata ctttcaagcc tacaactcct acataaggtg 720
gcggccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taatatagat 780
aatttagatg ttattctaac acaagctgca acatataacc atagaaaaat tttaacctat 840
tttattcctc aatcaaccta cgcacaaata gaacaatgtt tgttcgtggc gataaaaaca 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaacctttc catcaaactc 960
atccaaaaaa tcagccaata tgttgccact ttcaattcaa caaatataat aggcattctg 1020
agtatgaagc ggaaaaagaa gatatatttg gatatcatat tgacaaaatt tgtaaaaaat 1080
gctattttta ataaatttgt cgttcgatgt atggagagat tttctataaa cccggaaaga 1140
atcgtcaaaa tggctgcgcg tataaataag atgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggc tagacttaaa caccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg aacactgcta ttaccatatg 1320
caaggggaag aaatttttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
ttcgacgttt tttataattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ctaatatcaa catcgtgaac 1500
aagtatattg gcaacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattatatg ccttag 1596
<210> 141
<211> 1596
<212> DNA
<213> African swine fever virus
<400> 141
atgttctctc tccagaactt atgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgatt atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgggcaggaa acaactgtgt gcttatacaa caacataccc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtgg gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggta accgctacaa cttaattcgt 300
aaatatgatg atcaaatcaa ggaccatcat gacattctgc cattcattga tgatccaatc 360
atatttcaca aatgccatat catgcggcga tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg tgttcttctt tattttaaat atacattaga ggatgatttg 480
cccctcgttc atttacttat tgaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggatatatg aaaacctaca tgtctgccat ataatagata cctttgactg tgctattgcc 600
cataaagatc tacgtttata ttgtttgggg tatacattta tatacaacag gattgtaccc 660
tataagtatc atcatttaga tattctcata ctttcaagcc tacaactcct acataaggtg 720
gcggccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taatatagat 780
aatttagatg ttattctaac acaagctgca acatataacc atagaaaaat tttaacctat 840
tttattcctc aatcaaccta cgcacaaata gaacaatgtt tgttcgtggc gataaaaaca 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaacctttc catcaaactc 960
atccaaaaaa tcagccaata tgttgccact ttcaattcaa caaatataat aggcattctg 1020
agtatgaagc ggaaaaagaa gatatatttg gatatcatat tgacaaaatt tgtaaaaaat 1080
gctattttta ataaatttgt cgttcgatgt atggagagat tttctataaa cccggaaaga 1140
atcgtcaaaa tggctgcgcg tataaataag atgatgttag tgaaaaaaat atctgaacat 1200
gtttggaaaa atcatgcggc tagacttaaa caccttaaac atgcggtaca cacgatgaag 1260
cataaagatg ggaaaaatag actcatgaac tttatctatg aacactgcta ttaccatatg 1320
caaggggaag aaatttttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
ttcgacgttt tttataattg ttgtatccta gatacgatac gattcaaaag ccttctttta 1440
gattgttcac atatcatagg taaaaacgct catgatgcta ctaatatcaa catcgtgaac 1500
aagtatattg gcaacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattatatg ccttag 1596
<210> 142
<211> 1596
<212> DNA
<213> African swine fever virus
<400> 142
atgttctctc tccagaactt atgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttgtacaa caacataccc tcattcccgt aaacgaagcc 180
ctgagaatag cagcgtctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
ggaaaccttt actatgctat tataggagct ctagagggca accgccacga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc cattcattga caatccagtc 360
atatttcaca aatgccatat aatgcggcga tgcttttttg attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg cgttcttctt tattttaaat ataggttaga gaatgatttg 480
cccctcgctc atttacttgt tgaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggttatatg aaaacctaca tatctacaat ataatggaga cctttgaatg tgctattgcc 600
cataaggatc tacgtctata tcgtttgggg tatacattta tatataacag gatcgtaccc 660
tataagtatc attatttaga tgttctcatt ctttcaggcc tacatctcct gtataaggtg 720
gcagccaaag gatacttaga ttttatccta gaaaccttaa agtatgatca taacaatgat 780
aatttagata ttattctaac acaagctgta acatataacc atagaaaaat tttaacctat 840
tacattcctc aattaaccta tgcacaaata gaacaatgtt tgttcatggc gattaaaaaa 900
aaatcttcca agaaaacctt gaacttacta ctgtctcacc taaagctttc catcaaactc 960
atcaaaaaaa taagccaata tgttgccact tacaattcaa caaatataat aggcattctg 1020
aatatgaagc ggaaaaagaa gatatattta gatatcatat tgacaaaatt tgtaaaatac 1080
gctattttta ataaatatgt cgttcgttgt atggatacat tttccataaa cccggaaaga 1140
atcatcaaaa tggccgcgcg aataaataag atgttgttag tgaaaaaaat atctcaacat 1200
gcttggaaaa atcatgcggc tagacttaaa caccttaagc atgcggtata cacgatgaaa 1260
cataaagatg ggaaaaatag actcatgaac ttgatctatg atcactacta ttaccatatg 1320
caaggggaag aaatctttag cctcgcaaga ttttatgcaa tccatcatgc accaaagttg 1380
tttgacgttt tttatgattg ttgtctccta gatactatac gatttaaaag ccttctttta 1440
gattgttcac acatcatagg taaaaacgct catgatgcta ctaatatcac tatcgtgaac 1500
aagtatattg gcaacctgtt tgctatggga gttcttagca aaaaagaaat cttacaggac 1560
tatccatcca tctattctaa acattacatg ccttag 1596
<210> 143
<211> 1593
<212> DNA
<213> African swine fever virus
<400> 143
atgttttctc tccagaactt atgtcgaaaa accttacctg accgtaaact tcctgaattt 60
tttgacgatt atgtattaca actgctggga ttatactggg aaaaccatgg aacgattcaa 120
cgagcaggaa acaactgtgt acttatccaa caacataacc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtga gccttttatt agcttgggag 240
gggaaccttt actatgctat tataggggct ctagagggta atcgccacaa cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc catttattga cgatccagtc 360
atatttcaca aatgtcatat gatgcggcga tgctttttta attgtatttt gtatcaagct 420
gtaaaatata gtaagtttag cgttcttcta tattttaaat atatattaaa ggagaatttg 480
cccctcgttc attcacttat tgaaaaggcg tgtgaagatc ataattatga agttattaaa 540
tggatctatg aaaacctaca tatctatgaa ataatggata cctttaaatg tgctattgcc 600
cataaagatc tacatttata tagtttagga tatacattta tatataatag gatcgtaccc 660
tataagtatc atcatttaga tattcgcata ctttcaaggc tacaacttct acataaggtg 720
acagccaaag gatacttgga ctttatccta gaaaccttaa agtatgatca taataaagat 780
aatataaata ttattctgac acaagctgca acctataacc atagaaacat tttaacctat 840
ttcattcctc aatcaaccta cgcgcagata gaacaatgct tattcgtggc aataaaaaca 900
aacgcttcca agaaaacctt gaatttacta ttatctcacc taaacctttc tatcaaactc 960
gtcaaaaaat taagccaata tgttgttgct tacaagtcaa caaatatcat aagcattctg 1020
agtatgcagc aaaaaaagaa gatatattta gatatcattt tgacaaaggt tgtaaaaaac 1080
gctattttta ttaaatttgt cattggatgt atggttacat tttccataaa cccagaaaga 1140
attgtcaaaa tggccgcgcg aataaaaaag atgaagttag tgaaaaatat atctgaacat 1200
gtttggaaaa atcatgcggc taaacttaaa caccttaagc atgcggtaca cacgatgaag 1260
catcaagaag gaaaaaatag attaatgaac tttatctatg atcactgtta ttaccacatg 1320
caaggagaag agatctttag tcttgcaaga ttttatgcaa tccatcatgc gccaaaattg 1380
ttcgacgttt tttatgattg ttgtatccta gatacgatac gatttaaaag cctgctttta 1440
gattgttcat atatcatagc taaaaacgct catgatgcta gtattaacat cgtgaataag 1500
tatattggca atctatttgc tatgggggtt cttagcaaaa aagaaatctt acaagactat 1560
ccatccatct attctaagga ttacatgctt tag 1593
<210> 144
<211> 1593
<212> DNA
<213> African swine fever virus
<400> 144
atgttctctc tccagaactt atgtcgaaaa accttacctg actgtaaact tcctgagttt 60
tttgacgatt atgtattaca actgctgggc ttatactggg aaaatcatgg tacgattcaa 120
cgagcaggaa acaactgtgt acttatccaa caacataacc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga ggaaaattat gagatcgtga gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggga accaccacaa cttaattcgt 300
aaatacgatg accaaatcaa ggaccatcat gaaattctgc catttattga cgatccagtc 360
atatttcaca aatgtcatac aatgcggcga tgctttttta attgtatttt atatcaagct 420
gtaaaatata gtaagttcag cgttcttcta tactttaaat atatattaaa ggagaatttg 480
cccctcgtcc actcacttat tgaaaaggcg tataaatatc ataattatga ggttattaaa 540
tggatctatg aaaacctaca tatctatgat atcataaata cttttaaatg tgctattgcc 600
cataaagatc tacgtttata ttgtttaggg tatacatttg tatataatag aatcgtaccc 660
tataagtatt atcatttaga tattcgcatc cttttaaggc tacaacttct acataaggtg 720
acagccaaag gatacttgga ttttatccta gaaaccttaa agtatgatca taatacaaac 780
aatatagata ttatcctaac acaggctgca acctataacc atagaaacat tttaacctat 840
ttcattcctc aatcaaccta cgcacaaata gaacaatgtt tattcgtggc gataaaaaca 900
aatgcttcca agaaaacctt gaatttacta ttatctcacc taaatctttc tatcaaactc 960
gtcaaaaaat taagccaata tgttgtcgct tacaagtcaa caaatatcat aagcattctg 1020
agtaggcagc aaaaaaagaa gatatattta gatatcattt tgacaaaggt tgtaaaaaat 1080
gctgttttta ataaatttgt cattggatgt atggttacat tttccataaa cccagaaaga 1140
attgtcaaaa tggccgcgcg aataaaaaag atgaagttag taaaaaatat atctgaacat 1200
gtttggaaaa atcatgcggt taaacttaaa tatcttaagc atgcggtaca cacgatgaag 1260
catcaagaag gaaaaaatag attaatgaac tttatctatg atcactgtta ttaccacatg 1320
caagaagaag agatctttag cctcgcaaga ttttatgcaa tccatcatgc gccaaaattg 1380
ttcgacgttt tttatgattg ttgtatccta gatacgatac gatttaaaag cctgctttta 1440
gattgttcac atatcatagt taaaaacgct catgatgcta gtattaacat cgtgaacaag 1500
tatattggca atctatttgc tatgggagtt cttagcaaaa aagaaatctt acaagactat 1560
ccatctatct attctaagga ttacatgctt tag 1593
<210> 145
<211> 1593
<212> DNA
<213> African swine fever virus
<400> 145
atgttctctc tccaaaactt atgtcgaaaa accttacctg actgtaaact tcctgaattt 60
tttgacgatt atgtattaca actgctggga ttatactggg aaaaccatgg aacgattcaa 120
cgagcaggaa acaactgtgt acttatccaa caacataacc tcattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
gggaaccttt actatgctat tataggggct ctagagggta accgccacaa cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattctgc catttattga cgatccagtt 360
atatttcaca aatgtcatat aatgcggcga tgctttttta attgtatgtt gtatcaagct 420
gtaaaatata gtaagtttag cgttcttcta tattttaaat atatattaaa ggaaaatttg 480
cccctcgtcc actcactcat tgaaaaagcg tataaatatc ataattatga ggttattaaa 540
tggatctatg aaaatctaca tatctatgat atcataaata cttttaaata tgctattgcc 600
cataaagatc tacgtttata ttgtttaggg tatacatttg tatataatag gatcgtaccc 660
tataagtatt atcatttaga tattcgcatc cttttaaggc tacaacttct acataaggtg 720
acagccaaag gatacttgga ttttatccta gaaaccttaa agtatgatca taatacaaac 780
aatatagata ttatcctaac acaggctgca acctataacc atagaaacat tttaacctat 840
ttcattcctc aatcaaccta cgcacaaata gaacaatgct tattcgtggc aataaaaaca 900
aacgcttcca aaaaaacctt gaatttacta ttatctcacc taaacctttc tatcaaactc 960
gtcaaaaaat taagccaata tgttgtcgct tacaagtcaa caaatatcat aagcattctg 1020
agtatgcagc aaaaaaagaa gatatattta gatatcattt tgacaaaggt tgtaaaaaac 1080
gctgttttta ttaaatttgt cattggatgt atggttacat tttccataaa cccagaaaga 1140
attgtcaaaa tggccgcgcg aataaaaaag atgaagttag taaaaaatat atctgaacat 1200
gtttggaaaa atcatgcggc taaacttaaa catcttaagc atgcggtaca cacgatgaag 1260
catcaagaag gaaaaaatag actcatgaac tttatctatg atcactgcta ttaccacatg 1320
caaggagaag agatctttag tcttgcaaga ttttatgcaa tccatcatgc gccaaaattg 1380
ttcgacgttt tttatgattg ttgtatccta gatacgatac gatttaaaag cctgctttta 1440
gattgttcac atattatagc taaaaacgct catgatgcta gtattaacat cgtgaataag 1500
tatattggca atctatttgc tatgggagtt cttagcaaaa aagaaatctt acaagactat 1560
ccatccatct attctaaata tgacatactt tag 1593
<210> 146
<211> 1593
<212> DNA
<213> African swine fever virus
<400> 146
atgttctctc tccagaactt atgtcgaaaa acattacctg actgtaaact tcctgaattt 60
tttgacgaat atatattaca actgctggga ttatactggg aaaaccatgg aactattcaa 120
cgagcaggaa acaactgtgt gcttatccag caacataacc ttattcccgt aaatgaagcc 180
ctaagaatag cagcatctga agaaaattat gagatcgtga gccttttatt agcgtgggag 240
ggaaaccttt actatgctat tataggggct ctagagggca accgccccga cttaattcgt 300
aaatatgatg accaaatcaa ggaccatcat gaaattttgc cattcatcga cgatccaatc 360
atatttcaca aatgtcacat aatgcggcga tgctttttta attgtatttt atatcaagct 420
gtaaaatata gtaagtttcg tgttcttctt tattttaaac ataggttagg ggatgatttg 480
cccctcactc atttacttat tgaaaaggca tgtgaagatc ataattatga agttattaaa 540
tggatctatg aaaacctaca tagctacaat ataatggata cctttgaatg tgctattgcc 600
cataaggatc tacgtctata ttgtttgggg tatacattta tatataatag gatcgtaccc 660
tataagtatc atcatttaga tatttgcata ctttcaagcc tacaactcct gcataaggtg 720
gcagccaaag gatacttgga ttttatccta gaaaccttaa agtatgatca taacataaat 780
aatatagata ttattctaac acaagctgca acctataacc atagaaaaat tttaacctat 840
ttcattcctc aattaaccta cgcacagata gaacaatgtt tactagtggc gataaaaaca 900
aaagcttcca agaaaacctt gaacttacta ctgtctcacc taaacctttc catcaaactc 960
atcaaaaaaa taagccaata tgttgtcact tacaattcaa caaatatcat aagcattctg 1020
agtatgcggc ggaaaaagaa gatatattta gatatcattt tgacagagtt tgtaaaaaac 1080
gctattttta ataaatttgt cgttcgatgt atggatacat tttccataaa cccggaaaga 1140
attgtcaaaa tggccgcacg aataaatagg atgatgttag tgaaaaatat atctgaacgt 1200
gtttggaaaa atcatgcggt taaacttaaa caccttaagc atgcggtaca tacgatgaag 1260
catcaagaag gaaaaaatag actcatgaac tttatctatg atcactgcta ttaccacatg 1320
caaggggaag agatctttgg cctcgcaaga ttttatgcaa tccatcatgc acccaagttg 1380
tttgacgttt tttatgattg ctgcatgcta gatgctacac gatttaaaag cctgctttta 1440
gattgtccac atatcatagg taaaaacgct tatgatgctg gtatcaacct cgtgaacaaa 1500
tatattggca acctatttgc tatgggggtt cttagcaaaa aagaaatctt acaggactat 1560
ccatctatct attctaaaca tgatatgttt tag 1593
<210> 147
<211> 1581
<212> DNA
<213> African swine fever virus
<400> 147
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcata 120
ggagacgacc acatactcat acgacgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccttgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcattttatc ttaccattga ttcaagacgc gaatacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat gagagcgtat 480
cttcacgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaaa ccatacatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaaca tctcaagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggcaacata gataccgtcc tgacccaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaaa 840
cttttgttgc tggccgtgca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactaccgc gctatgtgat agagtacgag 960
tccaccttgg tgataaagat tttattaaaa aaaagagtga acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgtctta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagggaaaaa gtcatgtttt atttagccaa gctctatgtt 1320
gctcaaaacg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atattagact gtttagaaat tattactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct gtttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa agtaattcat 1560
tataaaacaa tacaatgtta a 1581
<210> 148
<211> 1581
<212> DNA
<213> African swine fever virus
<400> 148
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcata 120
ggagacgacc acatactcat acgacgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccttgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcattttatc ttaccattga ttcaagacgc gaatacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat gagagcgtat 480
cttcacgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaaa ccatacatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaaca tctcaagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggcaacata gataccgtcc tgacccaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaaa 840
cttttgttgc tggccgtgca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactaccgc gctatgtgat agagtacgag 960
tccaccttgg tgataaagat tttattaaaa aaaagagtga acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgtctta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagggaaaaa gtcatgtttt atttagccaa gctctatgtt 1320
gctcaaaacg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atattagact gtttagaaat tattactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct gtttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa agtaattcat 1560
tataaaacaa tacaatgtta a 1581
<210> 149
<211> 1581
<212> DNA
<213> African swine fever virus
<400> 149
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcata 120
ggagacgacc acatactcat acgacgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccttgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcattttatc ttaccattga ttcaagacgc gaatacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat gagagcgtat 480
cttcacgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaga ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaaca tctcgagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggcaacata gataccgtcc tgacccaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaaa 840
cttttgttgc tggctgttca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtatgag 960
tccaccttgg tgataaagat tttgttaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgaca aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgtttta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagggaaaaa gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaatg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atattagact gtttagaaat tgttactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct atttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa agtaattcat 1560
tataaaacaa tacaatgtta a 1581
<210> 150
<211> 1581
<212> DNA
<213> African swine fever virus
<400> 150
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcata 120
ggagacgacc acatactcat acgacgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccctgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcattttatc ttaccattga ttcaagacgc gaatacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat gagagcgtat 480
cttcacgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaga ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaaca tctcgagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggcaacata gataccgtcc tgacccaagc cgtaaagtac 780
aaccatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaag 840
cttttgttgc tggctgttca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtatgag 960
tccaccttgg tgataaagat tttgttaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgtctta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagggaaaaa gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaatg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atattagact gtttagaaat tgttactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct atttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa agtaattcat 1560
tataaaacaa tacaatgtta a 1581
<210> 151
<211> 1581
<212> DNA
<213> African swine fever virus
<400> 151
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcata 120
ggagacgacc acatactcat acgacgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccctgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcattttatc ttaccattga ttcaagacgc gaatacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat gagagcgtat 480
cttcacgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaga ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaaca tctcgagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggcaacata gataccgtcc tgacccaagc cgtaaagtac 780
aaccatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaag 840
cttttgttgc tggctgttca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtatgag 960
tccaccttgg tgataaagat tttgttaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgtctta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagggaaaaa gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaatg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atattagact gtttagaaat tgttactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct atttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa agtaattcat 1560
tataaaacaa tacaatgtta a 1581
<210> 152
<211> 1554
<212> DNA
<213> African swine fever virus
<400> 152
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcgta 120
ggagacgacc acatactcat acggcgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccgtcatagg agccttgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcatcttatc ttaccattga ttcaagacgc gaaaacgttt 360
gaaaaatgcc atgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctgt tctccaaaaa taccaagaag agctgtccat gagagcatat 480
ctttgcgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaaa ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga ctatgtactc cttaggatat attttccttt ttgatagagg gaacaccgaa 660
gctacgttgc taacgcaata tctcgagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggtaacata gatattgtcc tgacccaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaag 840
cttttgttgc tggccgtgca ggaaaaggct tctaaaaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtacgag 960
tccaccttgg tgataaagat tttattaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagcttttg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtatggga ggatgatcta gaacgactta ctcgtcttaa agatatggta 1200
tacaccgtaa agtacgaaca tgggaaaaaa atgttaatta aagtcataca cggcatatac 1260
aaaaacttat tatacggcga aaaagaaaag gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaacg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atgttagact gtttagaaat tgttactaaa 1440
aaatcttgct atagtattct ggaaatctta gaaaaacata tgatttccct atttactatg 1500
aaagttatga ctgaagaaga aaaaaaccta tgtttagaaa tattatataa gtaa 1554
<210> 153
<211> 1554
<212> DNA
<213> African swine fever virus
<400> 153
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcgta 120
ggagacgacc acatcctcat acggcgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aagaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccatcatagg agccttgcag ggtgatcaat atgacctgat ccataagtat 300
gaaaaccaaa tcggcgactt tcatcttatc ttaccattga ttcaagatgc gaaaacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaga acatgctaca 420
aaatacaaca tgctccctat tctccaaaca taccaagaag agctgtctat gagagcatat 480
cttcgcgaaa ccctatttga actagcgtgc ctgtggcaga ggtatgatgt ccttaaatgg 540
atagagcaaa ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctga cgatgtattc cttaggatat attcttcttt ttgatagaga gaacaccgaa 660
gctacgttgt taacacaaca tctcgagaag acagcggcca aagggctcct ctactttgtg 720
ctagaaacgt taaaatacgg cggtaacata gatatcgtcc tgactcaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaca tattgaaaag 840
cttttgttgc tggccgtgca ggaaaaggct tctaaaaaaa cattgaactt actgttgtcc 900
catctaaact actccgtgaa acgtatcaaa aaactgctgc gctatgtgat agagtacgag 960
tccaccttgg tgataaagat tttattaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagcttttg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacgga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgactta ctcgtcttaa aaatatggta 1200
tacaccataa agtacgaaca tgggaaaaaa atgttaatta aagtcatgca cggcatatac 1260
aaaaacttat tatacgacga aagagaaaag gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaacg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta aaccgcggtt taagcaacta atgttagact gtttagaaat tgttactaaa 1440
aaatcttgct atagtatcct ggaaatctta gaaaaacata ttatttccct atttactatg 1500
aaagttatga ctgaagagga aaaaaaccta tgtttagaaa tattatataa gtaa 1554
<210> 154
<211> 1569
<212> DNA
<213> African swine fever virus
<400> 154
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtat tacaacgatt aggactgtat tggagatgtc acggctccct tcaacgcgta 120
ggagacgacc acatactcat acggcgggat ctcatccttt ccaccaacga ggccttaaga 180
atggcgggag aagaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattacg ccatcatagg agccttgcag ggtgatcaat atgacctaat ccataagtat 300
gaaaaccaaa tcggcgactt tcatcttatc ttaccattga ttcaagatgc gaaaacgttt 360
gaaaaatgcc acgctttaga acgtttttgt ggtgtttcat gtctgctaaa acatgctaca 420
aaatacaaca tgctccctat tctccaaaca taccaagaag agctgtctat gagagtatat 480
cttcgcgaaa ccctatttga actagcatgc ctatggcaga ggtatgatgt ccttaaatgg 540
atagagcaaa ccatgcatgt ttacgaccta aaggttatgt ttaatattgc catctccaag 600
agagatctga ctatgtattc cttaggatat attcttcttt ttgatagaga gaacaccgaa 660
gctacgttgc taacgcaaca tctcgagaaa acagcggcca aggggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggtaacata gatatcgtcc tgtcccaagc cgtaaagtac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac ctcgtaaaaa tattgaaaaa 840
cttttgttgc tggctgttca ggaaaaggct tctaaaaaaa cattgaactt actgttgtcc 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtacgag 960
tccaccttgg tgataaagat tttattaaaa aaaagagtaa acctgataga tgccatgttg 1020
gaaaagatgg taagatattt ttctgcgacg aaagtgagga cgatcatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggct atacagaaaa tgagaacaga tatcgtaatc 1140
catacttctt atgtttggga ggatgatcta gaacgactta ctcgtcttaa aaatatggta 1200
tacgccataa agtatgaaca tgggaaaaaa atgttaatga aagtcatgca cggcatatac 1260
aaaaacttat tatacggcga aagagaaaag gtcatgtttc atttagccaa gctctatgtt 1320
gctcaaaacg cggccaccca attcagagac atttgtaagg actgttacaa actggatgtg 1380
gcacggttta agcaactaac gttaaactgt ttagaaatta ttactaaaaa atcttgctat 1440
agtatcctgg aaatcctaga aaaacatatt atttccctat ttactatgaa agttatgact 1500
gaagaagaaa aaaacctatg tttagaaata ttatataaag taattcatta taatacaata 1560
caatgttaa 1569
<210> 155
<211> 1581
<212> DNA
<213> African swine fever virus
<400> 155
atgttttccc ttcaagatct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacagtt aggactgtac tggaaacgtc acggctctct tcaacgcata 120
ggagacgacc acatactcat acggcgggac ctcatccttt ccaccaacga ggccttaaaa 180
atggcgggag aggaaggaaa caatgaagta gtaaagctct tgttactgtg ggagggaaac 240
cttcattatg ccatcatagg ggccttacag ggtgatcaat atgatctgat ccataagtat 300
gaaaaccaaa tcgaagacta tcatcatatc ttgccattga ttcaagatgc gaaaacgttt 360
gaaaaatgcc acgccttaga acgtttttgt gatgttccat gtctgctaga acatgctaca 420
aaacacaaca tgctccctat tctccaaaaa taccaagaag agctgtctat aagagtgtat 480
cttcgcgaaa ccctattcga actagcatgc ctatggcaga ggtatgatgt tcttaaatgg 540
atagagcaaa ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctaa gcatgtactc cttaggatat gttctccttt ttgatagagg aaacatcgaa 660
gctacgttcc taacgcaaca tctcgagaag acagcggcca aagggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggtaactta aatatcgtcc tgtcccaagc cgtaaaatac 780
aatcatagaa aacttttgga ttattttctg cgtcaactac ctcgtaaaaa tattgaaaaa 840
cttttgttgc tggccgtgca ggaaaaggct tctaaaaaaa cattgaacct actgttgtca 900
cacttaaact actccgtgaa acacatcaaa aaactgctgc gctatgtgat agagtacgag 960
tctaccttgg tgataaaact tttattgaaa aaaagagtaa acctgataga cgccgtgttg 1020
gaaaagaatg taagatattt ttctgcgatt aaagtgagga ctattatgga tgagctttcg 1080
attagtccgg aaagagtcat taagatggcc atacagaaaa tgagaacgga tattgtgatt 1140
cagacttctt atatttggga ggatgatcta gaaagactta ttcgtcttaa aaatatggta 1200
tacaccataa agtatgaaca tgggaaaaaa atgttaatta aagttattca cggcatatac 1260
aaaaacttat tatacggcga aaaagaaaaa gtcatgtttc atttagccaa actctatgtt 1320
gctcaaaacg cggccaccca attcagggac atttgtaagg actgttgcaa actggatgtg 1380
gcgcggttta aaccgcggtt taaacaacta attttagact gtttagaaat ggttactaaa 1440
aaatcttgct ttagtattat agaaatctta gaaaactata ttatttccct atttgtgatg 1500
aaagtcatca ctgaagaaga aaaaaaccta tgtttagaac tattatataa agtaattagt 1560
tacaaaacga tataatgtta a 1581
<210> 156
<211> 1581
<212> DNA
<213> African swine fever virus
<400> 156
atgttttccc ttcaagacca ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacggtt aggactgtac tggggacgtc acggctctct tcaacgaatc 120
ggggacgatc acatactcat acggcgggac ctcatccttt ccaccaacga ggccttaaaa 180
atggcgggag aagaaggaaa caatgaagta gtaaagctct tgttactgtg ggagggaaat 240
cttcattatg ctatcatagg ggctttacag ggtgatcaat atgacctaat ccataagtat 300
gaaaaccaaa tcgaagacta tcatcatatc ttaccattga ttcaagatgc ggaaacgttt 360
gaaaaatgcc acgccttaga acgtttttgt gatgttccat gtctgctaga acatgctaca 420
aaacacaaca tgctccctat tctccaaaaa tatcaagaag agttgtctat aagagtgtat 480
ctacgcgaaa ccctattcga actagcatgc ctatggcaga ggtatgatat tcttaaatgg 540
atagagcaaa ccatgcatgt ttacgatcta aaaattatat ttaatattgc catctccaag 600
agggatctaa gcatgtactc cttaggatat gttctccttt ttgatagagg gaacaccgaa 660
gctaccttgt taacgcaaca cctcgagaag acagcggcca aggggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggtaactta aatatcgtcc tgttccaagc cgtaaaatac 780
aatcatagaa aacttttaga ttattttctg cgtcaactac cccgtaaaaa tattgaaaaa 840
cttttgttgc tggctgtgca ggaaaaagct tctaagaaaa cattgaactt actgttgtca 900
catttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtacgag 960
tctaccttgg tgataaagat tttattaaaa aaaagagtaa acctaataga cgccgtgttg 1020
gaaaagactg taagatattt ttctgagacg aaagtaaaga ctattatgga tgagctttcg 1080
attaatccgg aaaaagtcat taagatggcc atacagaaaa tgagaacgga tattgtgatc 1140
caaacttctt atatttggga ggatgatcta gaaagactta ttcgtcttaa aaatatggta 1200
tacaccataa agtatgaaca tgggaaaaaa atgttaatga aagttattca cggcatatac 1260
aaaaacttat tacacgatga aaaagaaaaa gtcatgtttc atttagccaa gttctatatt 1320
gctcaaaacg cggccaccca attcagagac atttgtaaag actgttgcaa actggatgtg 1380
gcgcggttta aaccgcggtt taaacaacta attttagact gtttagaaat tgttactaaa 1440
aaatcttgct ttagtattat agaaatttta gaaaaccata ttatttccct atttatgatg 1500
aaagttatca ctgaagatga aaaaaaccta ggtttagaat tattatataa agtaattagt 1560
tacaaaatga tatcatatta a 1581
<210> 157
<211> 1581
<212> DNA
<213> African swine fever virus
<400> 157
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcacgtac tacaacaatt ggggctgtac tgggaaaaac acggctctct tcaacgaata 120
gggaacgatc acatactcat acggcgggat ctcatccttt ctatcaacga ggccttaaaa 180
atagcggcag aggaaggaaa caatgaagta gtaaagcttt tgttactatg gaagggaaat 240
cttcattatg ccatcatagg agctttggag ggtgaccaat atgacctgat ctatacgtat 300
gaaaaccaaa ttgaagacta tcatcatatc ttgccattga ttcaagatgc gaaaacgttt 360
gaaaaatgcc acgccttgga acgtttttgt gatgttccat gcctgctaga gcatgctata 420
aaacacaaca tgctccctat tctccaaaaa tatcaagaag aactgtttat aagagtgtat 480
ctccgcgaaa ccctatttga actagcatgc ctatggcaga ggtatgatat tcttaaatgg 540
atagagcaaa ccatgcatgt ttacgatcta aaaattatat ttaatattgc catctccaag 600
agggatctaa gcatgtactc cttaggatat gttctccttt ttgatagagg gaacaccgaa 660
gctaccttgt taacgcaaca cctcgagaag acagcggcca aggggctcct ccactttgtg 720
ctagaaacgt taaaatacgg cggtaacata aacatcgtcc tatcccaagc cgtaaaatac 780
aatcatagga aacttttaga ttattttctg cgtcaactac ctcgtaaaaa tattgaaaaa 840
cttttgttgt tagccgtaca ggaaaaggct tctaagaaaa cattgaactt actgttgtct 900
tatttaaact actccgtgaa acgcatcaaa aaactgctgc gctatgtgat agagtacgag 960
tccacactgg tgataaggat tttattaaaa aaaagaataa acctaataga cgccgtgttg 1020
gaaaagactg taagatattt ttctgagacg aaagtaaaga ctattatgga tgagctttcg 1080
attaatccgg aaaaagttat taagatggcc atacagaaaa tgagaacgga tattgtgatc 1140
caaacttctt atatttggga ggatgatcta gaaagactta ttcgtcttaa aaatatggta 1200
tacaccataa agtatgaaca tgggaaaaaa atgttaatga aagttattca cggcatatac 1260
aaaaacttat tacacgatga aaaagaaaaa gtcatgtttc atttagccaa gttctatatt 1320
gctcaaaacg cggccaccca attcagagac atttgtaaag actgttgcaa actggatgtg 1380
gcgcggttta aaccgcggtt taaacaacta attttagact gtttagatat tattactaaa 1440
aaaacgtgcc tcaatattat ggaaatctta gaaaatcata ttatttcgct atttgctatg 1500
aaaatgatga ctgaagatga aaaaaaccta ggtttagaat tattatataa agtaattagt 1560
tacaaaatga tatcatatta a 1581
<210> 158
<211> 1575
<212> DNA
<213> African swine fever virus
<400> 158
atgttttccc ttcaagacct ttgccgaaag catcttttta ttcttcccga tgtttttggc 60
gagcatgtac tacaacaatt ggggctgtac tgggaaaaac acggctctct tcaacgaata 120
gggaacgatc acatactcat acggcgggat ctcatccttt ctatcaacga ggccttaaaa 180
atagcggcag aggaaggaaa caatgaagta gtaaagctct tgttactgtg gaagggaaat 240
cttcattatg ccatcatagg agccttgcag ggtgaccaat atgacctcat ccatacgtac 300
gaaaaccaaa tcgaagacta tcatcatatc ttgccattga ttcaagatgc gaaaacgttt 360
gaaaaatgcc acgccttgga acgtttttgt gatgttccat gcctactaga acatgctaca 420
aaacacaaca tgctccctat tctccaaaaa taccaagaag agctgtttat aagagtgtat 480
ctccgcgaaa ccctatttga actagcatgc ctatggcaga ggtatgatat ccttaaatgg 540
atagagcaaa ccatgcatgt ttacgaccta aagattatgt ttaatattgc catctccaag 600
agggatctaa gcatgtactc tttagaatat attctctttt ttaatagagg gaacaccgat 660
gttgcgttag caacgttgct aacgcaacat ctcgagaaga cagcggccaa ggggctcctc 720
cactttgtgc tagaaacgtt aaaatacggc ggtaacataa acatcgtcct ctcccaagcc 780
gtaaaataca atcatagaaa acttttagat tattttctgc gtcaactacc tcgtaaaaat 840
attgaaaaac ttttgttgct ggccgtacag gaaagggctt ctaagaaaac attgaactta 900
ctgttgtctt atttaaacta ctccgtgaaa cgcatcaaaa aactgctgcg ctatgtgata 960
gagcatgagt ccacactggt gataaggatt ttattaaaaa aaagaataaa cctaatagac 1020
gccgtgttgg aaaagactgt aagatatttt tctatgacta aagtgaggac gatcatggat 1080
gagctttcga ttaatccgga aaaagtcatt aaaatggccg tgcagaaaat gagaacggat 1140
atcgtgatcc atacttctta tgtttgggag gatgatctag aaagacttat tcgtcttaaa 1200
aatatgctat acactataaa gtatgagcat ggaaaaaaaa tgctaattaa agtcattcac 1260
ggcatataca aaaacttata cggcgaaaaa gaaaaagtca tgtttaattt ggccaagttc 1320
tatgctgctc aaaacgcggc cacccaattc aaagacactt gtaaagactg ttgcaaactg 1380
gatgtggcgc ggtttaaaca actaatttta gactgtttag acattattac taaaaaaacg 1440
tgcctcagta tcatggaaat cttagaaaat catattattt cgctatttgc tatgaaaatg 1500
atgacggagg atgaaaaaaa cttaggttta gaaatattat ataaagtaat tagttacaaa 1560
atgatatcat attaa 1575
<210> 159
<211> 350
<212> PRT
<213> African swine fever virus
<400> 159
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asn Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Val Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Ser Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 160
<211> 350
<212> PRT
<213> African swine fever virus
<400> 160
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asn Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Val Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Ser Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 161
<211> 350
<212> PRT
<213> African swine fever virus
<400> 161
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asn Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Ser Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Met Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 162
<211> 350
<212> PRT
<213> African swine fever virus
<400> 162
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Gly Pro Ile Thr Phe Asp His Asn Leu Lys Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asn Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Arg Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Ala Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Ala Phe Glu Glu Gly Thr Ile Ala Leu Gly Glu Gly Tyr Lys Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 163
<211> 350
<212> PRT
<213> African swine fever virus
<400> 163
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Gly Pro Ile Thr Phe Asp His Asn Leu Lys Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Arg Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile Tyr Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Val Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Ala Phe Glu Glu Gly Thr Ile Ala Leu Gly Glu Gly Tyr Lys Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Val Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 164
<211> 350
<212> PRT
<213> African swine fever virus
<400> 164
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp His Asp Gly Pro Ile Thr Phe Asp His Asn Leu Lys Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asn Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Ala Phe Glu Glu Gly Thr Ile Ala Leu Gly Glu Gly Tyr Lys Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Val Ser Lys Asn Met Met Ile Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 165
<211> 350
<212> PRT
<213> African swine fever virus
<400> 165
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Tyr Tyr Asp Leu Trp
20 25 30
Trp His Asp Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Lys Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Ala Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Ser Ser Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Lys
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Ile Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Ile Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile Tyr Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Met Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Thr Thr Ile Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Phe Ser Lys Asn Met Met Ile Phe Leu Ser Tyr Asp Leu Arg
340 345 350
<210> 166
<211> 350
<212> PRT
<213> African swine fever virus
<400> 166
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Val Pro Thr Asn Gln His Tyr Leu Leu Lys Tyr Tyr Asp Leu Trp
20 25 30
Trp Tyr Asn Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ser Gly Ile Lys Glu Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Ser Leu Ile Lys Leu Phe Thr Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Arg Asp Leu Cys Gln Glu Leu Gly Ala Lys Glu Ile Leu Asn Glu Glu
100 105 110
Glu Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Ile Leu Gln
130 135 140
Lys Val Asn Asn Leu Lys Leu Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Leu Leu Ser
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Val Arg Tyr Ser Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile His Met Asp Ile Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Met Tyr Tyr Cys
245 250 255
Tyr Met Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Gly Thr Thr Ala Leu Gly Glu Gly Tyr Glu Leu Ile
290 295 300
Lys Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Thr Thr Ile Pro Leu
305 310 315 320
Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn Tyr
325 330 335
Phe Ser Lys Asn Met Met Ile Phe Leu Ser Tyr Asp Leu Arg
340 345 350
<210> 167
<211> 349
<212> PRT
<213> African swine fever virus
<400> 167
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Leu Pro Thr Asp Gln Tyr Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp Tyr Asp Ser Pro Ile Thr Phe Asp His Asn Leu Gly Leu Ile Lys
35 40 45
Ser Ala Gly Ile Lys Asp Gly Leu Asp Leu Asn Thr Ala Leu Val Lys
50 55 60
Ala Val Arg Glu Asn Asn Tyr Asn Leu Ile Lys Leu Phe Thr Glu Trp
65 70 75 80
Gly Ala Asp Ile Asn Tyr Gly Leu Val Ser Val Asn Thr Glu His Thr
85 90 95
Arg Asp Leu Cys Arg Glu Leu Gly Ala Lys Glu Thr Leu Asn Glu Glu
100 105 110
Glu Ile Leu Arg Ile Phe Ile Asp Leu Lys Phe Tyr Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asn Asn Pro Leu Leu Gln
130 135 140
Lys Val Asn Asn Leu Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Leu Ile Lys Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Asn
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Val Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile Tyr Met Asp Leu Glu Glu Met Met
225 230 235 240
Arg Val Ala Cys Ile Lys Asp His Asn Leu Ser Thr Ile Tyr Tyr Cys
245 250 255
Tyr Val Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Ala Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Met Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Val Phe Glu Glu Asn Met Pro Val Gly Glu Gly Tyr Glu Leu Ile Arg
290 295 300
Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ser Thr Ala Pro Leu Pro
305 310 315 320
Lys Asn Thr Asp Pro Glu Ile Ile Asp His Val Leu Lys Asn Tyr Lys
325 330 335
Ser Lys Asn Met Met Thr Phe Leu Ser Tyr Asp Leu Arg
340 345
<210> 168
<211> 351
<212> PRT
<213> African swine fever virus
<400> 168
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Gly Gln
1 5 10 15
Cys Leu Pro Glu Asp Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp Asn Asn Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Ser Ala Gly Leu Gln Glu Gly Leu Asp Leu Asn Met Ala Leu Val Lys
50 55 60
Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu Phe Thr Glu Trp
65 70 75 80
Gly Ala Asn Ile Asn Tyr Gly Leu Ile Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Lys Thr Leu Asn Glu Gly
100 105 110
Asp Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe His Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asp Asn Leu Leu Leu Lys
130 135 140
Lys Val Asn Asn Leu Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Ile Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Asn
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Val Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile Cys Met Asp Leu Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Ser Leu Ser Thr Ile Tyr Tyr Cys
245 250 255
Tyr Met Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Ile Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Ala Phe Glu Glu Gly Met Ala Leu Val Gly Gln Glu Gly Tyr Glu Pro
290 295 300
Ile Arg Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro
305 310 315 320
Leu Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Glu Leu Lys Asn
325 330 335
Tyr Phe Ser Lys Asn Met Met Val Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 169
<211> 351
<212> PRT
<213> African swine fever virus
<400> 169
Met Leu Pro Ser Leu Gln Ser Leu Thr Lys Lys Val Leu Ala Arg Gln
1 5 10 15
Cys Leu Pro Glu Asp Gln His Tyr Leu Leu Lys Cys Tyr Asp Leu Trp
20 25 30
Trp Asn Asn Ala Pro Ile Thr Phe Asp His Asn Leu Arg Leu Ile Lys
35 40 45
Leu Ala Gly Ile Gln Glu Gly Leu Asp Leu Asn Met Ala Leu Val Lys
50 55 60
Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu Phe Thr Glu Trp
65 70 75 80
Gly Ala Asn Ile Asn Tyr Gly Leu Ile Ser Val Asn Thr Glu His Thr
85 90 95
Trp Asp Leu Cys Arg Glu Leu Gly Ala Lys Lys Thr Leu Asn Glu Gly
100 105 110
Asp Ile Leu Gln Ile Phe Ile Asp Leu Lys Phe Tyr Lys Thr Ser Ser
115 120 125
Asn Ile Ile Leu Cys His Glu Val Phe Ser Asp Asn Leu Leu Leu Lys
130 135 140
Arg Val Asn Asn Leu Lys Met Arg Ile Glu Ile Phe Trp Glu Leu Arg
145 150 155 160
Glu Ile Ile Glu Lys Thr Asp Leu Leu Asn Asn Glu Phe Ser Leu Asn
165 170 175
Thr Leu Leu Leu Lys Tyr Trp Tyr Ala Ile Ala Val Arg Tyr Asn Leu
180 185 190
Lys Glu Ala Ile Gln Tyr Phe Tyr Gln Lys Tyr Thr His Leu Asn Thr
195 200 205
Trp Arg Leu Thr Cys Ala Leu Cys Phe Asn Asn Val Phe Asp Leu His
210 215 220
Glu Ala Tyr Glu Lys Asp Lys Ile Cys Met Asp Leu Glu Glu Met Met
225 230 235 240
Arg Ile Ala Cys Ile Lys Asp His Asn Leu Ser Thr Ile Tyr Tyr Cys
245 250 255
Tyr Met Leu Gly Ala Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Glu Asn Ile Phe Phe Cys Met Asp Leu Gly Ala Asp
275 280 285
Ala Phe Glu Glu Gly Met Ala Leu Val Gly Gln Glu Gly Tyr Glu Pro
290 295 300
Ile Arg Asn Ile Leu Ser Leu Lys Ile Tyr Ser Pro Ala Thr Thr Pro
305 310 315 320
Leu Pro Lys Ser Thr Asp Pro Glu Ile Ile Asp His Ala Leu Lys Asn
325 330 335
Tyr Phe Ser Lys Asn Met Met Val Phe Leu Thr Tyr Asp Leu Arg
340 345 350
<210> 170
<211> 353
<212> PRT
<213> African swine fever virus
<400> 170
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Ile Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Cys Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Arg Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Gly Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Arg Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Ile Leu Glu Asn Lys Phe Val Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Gly Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Asp Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Glu Asn Ile Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Ala Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 171
<211> 353
<212> PRT
<213> African swine fever virus
<400> 171
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Ile Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Cys Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Arg Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Gly Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Arg Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Ile Leu Glu Asn Lys Phe Val Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Gly Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Asp Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Glu Asn Ile Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Ala Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 172
<211> 353
<212> PRT
<213> African swine fever virus
<400> 172
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Asn Gln Ser Leu Ser Ile Asp Glu His Cys Ile Leu Lys His Cys Gly
20 25 30
Leu Trp Trp His Asp Val Pro Leu Lys Leu Cys Met Asp Arg Gly Gln
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu His Ile
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asp Asp Ile Phe Arg Ile Phe Thr Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Asp Ile Phe Met Asn Asn
130 135 140
Pro Asn Ile Glu Asp Lys Phe Thr Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Gly Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Glu Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Glu Asn Ile Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Ala Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 173
<211> 353
<212> PRT
<213> African swine fever virus
<400> 173
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Thr Asp Glu His Cys Ile Leu Lys His Cys Gly
20 25 30
Leu Trp Trp His Asp Val Pro Leu Lys Leu Cys Met Asp Arg Gly Gln
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu His Ile
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala His Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Glu His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Arg Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Asn Ile Glu Asn Lys Phe Thr Ile Gln Leu Arg Gly Leu Ile Cys
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Glu Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Glu Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr His Phe
290 295 300
Leu Ser His Ser Leu Thr Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 174
<211> 353
<212> PRT
<213> African swine fever virus
<400> 174
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Thr Asp Glu His Cys Ile Leu Lys His Cys Gly
20 25 30
Leu Trp Trp His Asp Val Pro Leu Lys Leu Cys Met Asp Arg Gly Gln
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu His Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala His Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Glu His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Lys Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Arg Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Asn Ile Glu Asn Lys Phe Thr Ile Gln Leu Arg Gly Leu Ile Cys
145 150 155 160
Lys Arg Leu Trp Arg Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Glu Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Gly Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Asp Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr His Phe
290 295 300
Leu Ser His Ser Leu Ala Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Gly
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 175
<211> 353
<212> PRT
<213> African swine fever virus
<400> 175
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys His Cys Gly
20 25 30
Leu Trp Trp His Asp Val Pro Leu Lys Leu Cys Met Asp Arg Gly Gln
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu His Ile
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala His Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Glu His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asp Asp Val Phe Arg Ile Phe Thr Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Arg Ile Ile Leu Cys His Asp Ile Phe Met Asn Asn
130 135 140
Pro Asn Ile Glu Asn Lys Phe Thr Ile Gln Leu Arg Gly Leu Ile Cys
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Glu Cys
180 185 190
Lys Asp Ala Ile Cys Phe Leu Glu Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Phe Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Glu Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Ser Thr Lys Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Ile Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Ala Leu Asp Ile Phe Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Phe Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 176
<211> 353
<212> PRT
<213> African swine fever virus
<400> 176
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Cys Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Arg Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Arg Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Ile Leu Glu Asn Lys Phe Val Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Lys Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Val Cys
180 185 190
Lys Asn Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Lys Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Cys Ala Lys Asp Asn Asn Leu Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Ser Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Thr Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 177
<211> 353
<212> PRT
<213> African swine fever virus
<400> 177
Met Ser Leu Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Gln Cys Leu Ser Ile Asp Glu His Cys Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Cys Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Arg Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Asn Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ile Arg Glu Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Asn Asp Ile Phe Arg Ile Phe Thr Arg Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Met Asn Asn
130 135 140
Pro Met Leu Glu Asn Lys Phe Val Ile Gln Leu Arg Gly Leu Ile Tyr
145 150 155 160
Lys Arg Leu Trp Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Asn
165 170 175
Asp Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Val Cys
180 185 190
Lys Asn Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Leu Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Glu Met Tyr His Lys Lys Lys Val Gln Ile Asp Val His Asp Met Ile
225 230 235 240
Cys Leu Ala Cys Ala Lys Asp Asn Asn Leu Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Val Gly Asn Ile Phe Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Arg Ala Ile Ala Glu Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Thr Leu Asp Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Lys Ile Ser Ser Leu Leu Lys Asp
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Trp Glu Tyr Ser His Asn Ile
340 345 350
Leu
<210> 178
<211> 353
<212> PRT
<213> African swine fever virus
<400> 178
Met Ser Ala Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Thr Ser Cys Leu Ser Ile Asp Glu His Ile Leu Lys Tyr Cys Asp
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Tyr Met Asp Arg Gly Arg
35 40 45
Ile Gln Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Cys Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Asn Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Leu Gly Ala Asn Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Val Arg Asp Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Glu Asp Tyr Asp Ile Phe Cys Ile Phe Asn Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Val Ile Leu Cys His Glu Ile Phe Ile Asn Asn
130 135 140
Pro Asn Leu Glu Asn Lys Phe Ala Ala Gln Leu Arg Arg Leu Ile Tyr
145 150 155 160
Lys Arg Leu Cys Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Ser
165 170 175
Glu Leu Leu Val Lys Tyr Trp Tyr Ala Lys Ala Val Gln Tyr Asp Tyr
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asn Glu
195 200 205
Trp Arg Leu Lys Cys Tyr Leu Tyr Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Asp Ile Tyr His Lys Glu Lys Ile Gln Ile Asp Val Asn Glu Met Leu
225 230 235 240
Ser Leu Ala Cys Ile Arg Asp Asn Asn Pro Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Tyr Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Ser Ala Ile Ala Arg Gln Lys Gly Tyr Asn Phe
290 295 300
Leu Ser His Ser Leu Val Leu Asn Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asn
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Leu Asp Tyr Ser His Asn Ile
340 345 350
Leu
<210> 179
<211> 353
<212> PRT
<213> African swine fever virus
<400> 179
Met Ser Ser Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Ser Thr Ser Cys Leu Ser Ile Asp Glu His Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Tyr Ile Asp Arg Gly Arg
35 40 45
Ile Tyr Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Cys Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Leu Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Tyr Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ala Arg Asp Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Asp Asp Tyr Asp Ile Phe Cys Ile Phe Asn Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Ile Asn Asn
130 135 140
Pro Lys Leu Glu Asn Asn Phe Ala Ala Gln Leu Arg Arg Leu Ile Tyr
145 150 155 160
Lys Arg Leu Cys Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Ser
165 170 175
Glu Leu Leu Val Lys Tyr Trp Tyr Ala Asn Ala Val Gln Tyr Asp His
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asp Glu
195 200 205
Trp Arg Leu Lys Cys Tyr Leu Cys Tyr Asn Lys Ile Tyr Glu Leu His
210 215 220
Asp Ile Tyr His Lys Lys Lys Ile Gln Ile Asp Val Asn Glu Met Leu
225 230 235 240
Ser Leu Ala Cys Ile Arg Asp Asn Asn Leu Leu Thr Ile Tyr Tyr Cys
245 250 255
Tyr Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln
260 265 270
Tyr Tyr Asn Ile Gly Asn Ile Tyr Phe Cys Ile Asp Leu Gly Gly Asn
275 280 285
Ala Phe Glu Glu Gly Ser Ala Ile Ala Arg Gln Asn Gly Tyr Asn Phe
290 295 300
Leu Cys His Ser Leu Ile Leu Asn Ile Tyr Ser Ser Asp Ala Ser Leu
305 310 315 320
Pro Leu Asn Leu Lys Val Pro Glu Glu Ile Ser Ser Leu Leu Lys Asn
325 330 335
Tyr Lys Ser Lys Asn Leu Ser Ile Ile Leu Asp Tyr Ser His Lys Ile
340 345 350
Leu
<210> 180
<211> 352
<212> PRT
<213> African swine fever virus
<400> 180
Met Ser Ser Pro Leu Ser Leu Gln Thr Leu Val Lys Lys Thr Val Ala
1 5 10 15
Gly Thr Ser Cys Leu Ser Ile Asp Glu His Ile Leu Lys Tyr Cys Gly
20 25 30
Leu Trp Trp His Asp Ala Pro Leu Lys Leu Tyr Ile Asp Arg Gly Arg
35 40 45
Ile Tyr Ile Lys Ser Gly Phe Leu Gly Glu Asp Ile Asp Leu Cys Val
50 55 60
Ala Leu Ile Ile Ala Val Lys Glu Asn Asn Tyr Ser Met Ile Lys Leu
65 70 75 80
Phe Thr Glu Trp Gly Ala Tyr Ile Asn Tyr Ser Leu Leu Ser Ile Asn
85 90 95
Thr Lys His Ala Arg Asp Leu Cys Arg Gln Leu Gly Ala Lys Glu Thr
100 105 110
Leu Asp Asp Tyr Asp Ile Phe Cys Ile Phe Asn Lys Ile Met His Asn
115 120 125
Lys Thr Ser Gly Ser Ile Ile Leu Cys His Glu Ile Phe Ile Asn Asn
130 135 140
Pro Asn Leu Glu Asn Asn Phe Ala Ala Gln Leu Arg Arg Leu Ile Tyr
145 150 155 160
Lys Arg Leu Cys Gly Leu Ile Glu Ile Lys Glu Thr Asp Glu Leu Ser
165 170 175
Glu Leu Leu Val Lys Tyr Trp Tyr Ala Asn Ala Val Gln Tyr Asp His
180 185 190
Lys Asp Ala Ile Cys Phe Leu Asp Glu Lys Tyr Thr Asp Leu Asp Glu
195 200 205
Trp Leu Lys Cys Tyr Leu Cys Tyr Asn Lys Ile Tyr Glu Leu His Asp
210 215 220
Ile Tyr His Lys Glu Lys Ile Gln Ile Asp Val Asn Glu Met Leu Ser
225 230 235 240
Leu Ala Cys Ile Arg Asp Asn Asn Leu Leu Thr Ile Tyr Tyr Cys Tyr
245 250 255
Ala Leu Gly Gly Asn Ile Asn Gln Ala Met Leu Thr Ser Val Gln Tyr
260 265 270
Tyr Asn Ile Gly Asn Ile Tyr Phe Cys Ile Asp Leu Gly Gly Asn Ala
275 280 285
Phe Glu Glu Gly Ser Ala Ile Ala Arg Gln Asn Gly Tyr Asn Phe Leu
290 295 300
Ser His Ser Leu Val Leu Asn Ile Tyr Ser Ser Asp Ala Ser Leu Pro
305 310 315 320
Leu Asn Leu Lys Asp Pro Glu Glu Ile Ser Ser Leu Leu Lys Asn Tyr
325 330 335
Lys Ser Lys Asn Leu Ser Ile Ile Leu Asp Tyr Ser His Lys Ile Leu
340 345 350
<210> 181
<211> 357
<212> PRT
<213> African swine fever virus
<400> 181
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Val Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Tyr Leu Lys Arg Leu Cys Ala Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Arg Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His His Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys His Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Ala Asp Phe Asp
275 280 285
Arg Ala Gln Leu Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Val Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 182
<211> 357
<212> PRT
<213> African swine fever virus
<400> 182
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Val Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Tyr Leu Lys Arg Leu Cys Ala Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Arg Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His His Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys His Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Ala Asp Phe Asp
275 280 285
Arg Ala Gln Leu Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Val Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 183
<211> 357
<212> PRT
<213> African swine fever virus
<400> 183
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Lys His Val Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val His Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Ser Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Arg Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His His Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Gln Lys Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys Tyr Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Thr Asp Phe Asp
275 280 285
Arg Ala Gln Arg Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Ala Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Ser Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 184
<211> 357
<212> PRT
<213> African swine fever virus
<400> 184
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Met Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val His Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Lys Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His His Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Lys Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys Tyr Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Thr Asp Phe Asp
275 280 285
Arg Ala Gln Arg Ile Ala His Lys Thr Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Ala Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Ser Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 185
<211> 357
<212> PRT
<213> African swine fever virus
<400> 185
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Met Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Arg Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Cys Val Pro
85 90 95
Thr Val His Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asn Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys Tyr Asn
130 135 140
Pro Leu Leu Glu Thr Ile Thr Arg Thr Thr Leu Asp Thr Val Met Tyr
145 150 155 160
Ser Cys Ser Lys Ile Pro Leu Met Gly Asp Thr Ala His His Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys Tyr Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Ser Leu Asn Leu Phe Phe Cys Ile Asp Leu Gly Ala Thr Asp Phe Asp
275 280 285
Arg Ala Gln Arg Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Leu Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Ala Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Arg Leu Lys Ala Tyr Thr
325 330 335
Ser Lys Asn Met Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 186
<211> 357
<212> PRT
<213> African swine fever virus
<400> 186
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val His Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Thr Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Lys Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn His Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Gln Lys Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys Tyr Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Thr Asp Phe Asp
275 280 285
Arg Ala Gln His Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Ala Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Arg Leu Lys Ser Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 187
<211> 357
<212> PRT
<213> African swine fever virus
<400> 187
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Val Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Tyr Leu Lys Arg Leu Cys Ala Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asn Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn Gln Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys His Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Ala Asp Phe Asp
275 280 285
Arg Ala Gln Leu Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Val Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Met Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 188
<211> 357
<212> PRT
<213> African swine fever virus
<400> 188
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Asn Cys Lys Gln Val Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Tyr Leu Lys Arg Leu Cys Ala Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Pro Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asn Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Thr Tyr
145 150 155 160
Thr Cys Ser Asn Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Lys Arg His Lys Asn Gln Leu Tyr Trp Arg Val
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Ile His Glu Leu Cys
210 215 220
Arg Glu Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Lys Asn Tyr Ala Ala Ile Tyr Tyr Cys His Arg Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Met Phe Phe Cys Ile Asp Leu Gly Ala Ala Asp Phe Asp
275 280 285
Arg Ala Gln Leu Ile Ala His Lys Ala Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Thr Leu Val Leu
305 310 315 320
Asp Val Thr Glu Pro Gln Glu Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Met Lys Arg Ala Glu Glu Tyr Leu Thr Ala His Pro Glu
340 345 350
Ile Ile Val Ile Asp
355
<210> 189
<211> 357
<212> PRT
<213> African swine fever virus
<400> 189
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Thr Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Lys His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Glu Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val His Leu Lys Arg Leu Cys Met Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Ser Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asp Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asp Thr Val Met Tyr
145 150 155 160
Thr Arg Ser Lys Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Ser Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Glu Lys His Lys Asn Gln Leu Tyr Trp Arg Leu
195 200 205
Thr Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Leu His Glu Leu Cys
210 215 220
Cys Lys Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Glu Asn Tyr Ala Ala Ile Tyr Tyr Cys His Met Leu
245 250 255
Gly Ala Ser Leu Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Leu Phe Phe Cys Ile Asp Leu Gly Ala Thr Asn Phe Asp
275 280 285
Arg Ala Arg Leu Ile Ala Arg Arg Val Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Leu Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Val Ser Leu Ile Leu
305 310 315 320
Asp Leu Thr Glu Pro Gln Ala Ile Tyr Asp Met Leu Asn Thr Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Gln Ala Glu Glu Tyr Phe Thr Ala His Pro Glu
340 345 350
Ile Val Val Ile Asp
355
<210> 190
<211> 357
<212> PRT
<213> African swine fever virus
<400> 190
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Thr Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Gln His Leu Gln Cys Phe Ser Glu Asp Asp Leu Cys Leu Asp Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val Asp Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Ser Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asp Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Leu Glu Thr Val Thr Arg Thr Thr Leu Asn Thr Val Met Tyr
145 150 155 160
Thr Arg Ser Lys Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Glu Lys His Lys Asn Gln Leu Tyr Trp Arg Leu
195 200 205
Ala Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Leu His Glu Leu Cys
210 215 220
Ser Lys Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Glu Asn Tyr Ala Ala Ile Tyr Tyr Cys His Met Leu
245 250 255
Gly Ala Ser Pro Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Leu Phe Phe Cys Ile Asp Leu Gly Ala Thr Asn Phe Asp
275 280 285
Arg Ala Arg Leu Ile Ala His Arg Val Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Ala Ser Leu Val Leu
305 310 315 320
Asn Ile Thr Glu Pro Gln Ala Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Phe Thr Ala His Pro Glu
340 345 350
Ile Val Val Ile Asp
355
<210> 191
<211> 357
<212> PRT
<213> African swine fever virus
<400> 191
Met Leu Ser Leu Gln Thr Leu Ala Lys Lys Val Val Ala Cys Asn Tyr
1 5 10 15
Leu Ser Ser Asp Tyr Asp Tyr Thr Leu Gln Arg Phe Gly Leu Trp Trp
20 25 30
Asp Leu Gly Pro Ile His Leu Cys Asn Thr Cys Lys Gln Ile Phe Ser
35 40 45
Tyr Gln His Leu Gln Cys Phe Ser Val Asp Asp Leu Cys Leu Asp Ala
50 55 60
Ala Leu Val Lys Ala Val Lys Ser Asp Asn Leu Glu Leu Ile Arg Leu
65 70 75 80
Phe Val Asp Trp Gly Ala Asn Pro Glu Tyr Gly Leu Ile Arg Val Pro
85 90 95
Ala Val His Leu Lys Arg Leu Cys Thr Glu Leu Gly Gly Leu Thr Pro
100 105 110
Val Ser Glu Ser Arg Leu Leu Glu Ile Leu Lys Glu Val Ala Asp Leu
115 120 125
Lys Ser Cys Ala Gly Val Leu Leu Gly Tyr Asp Met Phe Cys His Asn
130 135 140
Pro Leu Met Glu Thr Val Thr Arg Thr Thr Leu Asn Thr Val Met Tyr
145 150 155 160
Thr Arg Ser Lys Ile Pro Leu Thr Gly Asp Thr Ala His Leu Leu Leu
165 170 175
Thr Lys Phe Trp Phe Ala Leu Ala Leu Arg His Asn Phe Thr Lys Ala
180 185 190
Ile His Tyr Phe Tyr Glu Lys His Lys Asn Gln Leu Tyr Trp Arg Leu
195 200 205
Thr Cys Ser Leu Tyr Phe Asn Asn Ile Phe Asp Leu His Glu Leu Cys
210 215 220
Ser Lys Lys Glu Ile Cys Ile Ser Pro Asn Leu Met Met Lys Phe Ala
225 230 235 240
Cys Leu Arg Glu Glu Asn Tyr Ala Ala Ile Tyr Tyr Cys His Met Leu
245 250 255
Gly Ala Ser Pro Asp Tyr Gly Met Asn Leu Ser Ile Tyr Asn Asn Asn
260 265 270
Thr Leu Asn Leu Phe Phe Cys Ile Asp Leu Gly Ala Thr Asn Phe Asp
275 280 285
Arg Ala Arg Leu Ile Ala His Arg Val Tyr Met Tyr Asn Leu Ser Asn
290 295 300
Ile Phe Leu Val Lys Gln Leu Phe Ser Arg Asp Ala Ser Leu Val Leu
305 310 315 320
Asn Ile Thr Glu Pro Gln Ala Ile Tyr Asp Met Leu Lys Thr Tyr Thr
325 330 335
Ser Lys Asn Leu Lys Arg Ala Glu Glu Tyr Phe Thr Ala His Pro Glu
340 345 350
Ile Val Val Ile Asp
355
<210> 192
<211> 531
<212> PRT
<213> African swine fever virus
<400> 192
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asn Arg Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Thr Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Gln Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys His Arg Leu Glu Asp Asp Leu
145 150 155 160
Pro Phe Thr His Leu Leu Ile Glu Lys Ala Cys Lys Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asn Met Ile
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu His Leu Tyr Cys
195 200 205
Leu Gly Tyr Arg Phe Ile Tyr Asn Arg Ile Val Pro Asp Lys Tyr His
210 215 220
His Leu Asp Ile Arg Met Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Lys Asp Asn Ile Asn Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Ile Tyr Phe Ile Pro Gln Ser Thr His Ala
275 280 285
Gln Ile Glu Gln Cys Leu Leu Val Ala Ile Lys Ala Lys Ser Ser Arg
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Asn Leu
305 310 315 320
Ile Lys Lys Ile Ser His Tyr Val Ala Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Arg Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Lys Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Leu Lys Ile
370 375 380
Ala Ala Arg Ile Asn Arg Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Val Arg Leu Lys Tyr Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp Arg Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Val Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys Gln
515 520 525
Tyr Met Pro
530
<210> 193
<211> 531
<212> PRT
<213> African swine fever virus
<400> 193
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asn Arg Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Thr Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Gln Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys His Arg Leu Glu Asp Asp Leu
145 150 155 160
Pro Phe Thr His Leu Leu Ile Glu Lys Ala Cys Lys Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asn Met Ile
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu His Leu Tyr Cys
195 200 205
Leu Gly Tyr Arg Phe Ile Tyr Asn Arg Ile Val Pro Asp Lys Tyr His
210 215 220
His Leu Asp Ile Arg Met Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Lys Asp Asn Ile Asn Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Ile Tyr Phe Ile Pro Gln Ser Thr His Ala
275 280 285
Gln Ile Glu Gln Cys Leu Leu Val Ala Ile Lys Ala Lys Ser Ser Arg
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Asn Leu
305 310 315 320
Ile Lys Lys Ile Ser His Tyr Val Ala Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Arg Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Lys Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Leu Lys Ile
370 375 380
Ala Ala Arg Ile Asn Arg Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Val Arg Leu Lys Tyr Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp Arg Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Val Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys Gln
515 520 525
Tyr Met Pro
530
<210> 194
<211> 531
<212> PRT
<213> African swine fever virus
<400> 194
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Asn Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Gln Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Ser Phe Lys His Arg Leu Arg Asp Asp Leu
145 150 155 160
Pro Phe Thr His Leu Leu Ile Glu Lys Ala Cys Lys Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asn Met Ile
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Arg Phe Ile Tyr Asn Arg Ile Val Pro Asp Lys Tyr His
210 215 220
His Leu Asp Ile Arg Met Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Lys Asp Asn Ile Asn Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Ile Tyr Phe Ile Pro Gln Ser Thr His Ala
275 280 285
Gln Ile Glu Gln Cys Leu Leu Val Ala Ile Lys Thr Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Asn Leu
305 310 315 320
Ile Lys Lys Ile Ser His Tyr Val Ala Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Arg Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Lys Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Leu Lys Ile
370 375 380
Ala Ala Arg Ile Asn Arg Thr Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Val Arg Leu Lys Tyr Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp Arg Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Val Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 195
<211> 531
<212> PRT
<213> African swine fever virus
<400> 195
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln Arg Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Gly Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Ile
115 120 125
Arg Arg Cys Phe Phe Asn Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys His Arg Leu Glu Asp Asp Leu
145 150 155 160
Pro Leu Thr His Leu Leu Ile Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Thr Tyr Asp Ile Met
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Glu Tyr His
210 215 220
His Leu Asp Ile Leu Ile Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Asn Asp Asn Leu Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Phe Ile Pro Gln Leu Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Met Ala Ile Lys Arg Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Thr Leu Ser Ile Glu Leu
305 310 315 320
Ile Lys Lys Ile Ser Gln Tyr Val Val Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Lys Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Met Leu Thr Lys Tyr Val Lys Tyr Ala Ile Phe Asn Lys Tyr Val Val
355 360 365
Arg Cys Met Asp Arg Phe Ser Ile Asn Pro Glu Arg Ile Ile Lys Met
370 375 380
Ala Ala Arg Ile Asn Arg Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Ala Arg Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp Arg Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Gln Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asp Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Leu
530
<210> 196
<211> 531
<212> PRT
<213> African swine fever virus
<400> 196
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Ile Asn Glu Ala Leu Arg Thr Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys Tyr Arg Leu Glu Asp Asp Leu
145 150 155 160
Pro Leu Thr His Leu Leu Ile Glu Lys Ala Cys Glu Asn His Asn Tyr
165 170 175
Glu Val Ile Arg Trp Ile Tyr Glu Asn Leu His Ile Tyr Asn Met Ile
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Asn Lys Tyr His
210 215 220
His Ile Asp Ile Leu Ile Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Asn Asp Asn Leu Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Met Val Ala Ile Lys Thr Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Ile Lys Lys Ile Ser Gln Tyr Val Val Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Lys Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Leu Leu Thr Lys Phe Val Lys Asn Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Tyr Met Asp Thr Phe Ser Ile Asn Pro Glu Lys Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Asn Lys Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Ile Trp Lys Asn His Ala Ala Arg Leu Glu His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Glu Tyr Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asn Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Asp Asn Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 197
<211> 531
<212> PRT
<213> African swine fever virus
<400> 197
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys Tyr Arg Leu Glu Asn Asp Leu
145 150 155 160
Pro Leu Ala His Leu Leu Ile Lys Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asn Ile Met
180 185 190
Asp Thr Phe Gly Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Arg
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
Tyr Leu Asp Val Leu Ile Leu Ser Gly Leu His Leu Leu Tyr Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Asn Asp Asn Leu Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Tyr Ile Pro Gln Leu Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Met Ala Ile Lys Lys Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Lys Leu Ser Ile Lys Leu
305 310 315 320
Ile Lys Lys Ile Ser Gln Tyr Val Ala Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Asn Met Arg Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Lys Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Ile Lys Met
370 375 380
Ala Ala Arg Ile Asn Lys Met Leu Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Ala Trp Lys Asn His Ala Ala Arg Leu Lys His Leu Lys His Ala Val
405 410 415
Tyr Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Leu Ile
420 425 430
Tyr Asp His Tyr Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Leu Leu Asp Thr Ile Arg Phe Lys Asn Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Thr Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 198
<211> 531
<212> PRT
<213> African swine fever virus
<400> 198
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Gly Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg Tyr
85 90 95
Asn Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Asp Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Ile Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys Tyr Thr Leu Glu Asp Asp Leu
145 150 155 160
Pro Leu Val His Leu Leu Ile Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Val Cys His Ile Ile
180 185 190
Asp Thr Phe Asp Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
His Leu Asp Ile Leu Ile Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Ile Asp Asn Leu Asp Val Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Val Ala Ile Lys Thr Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Ile Gln Lys Ile Ser Gln Tyr Val Ala Thr Phe Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Ser Met Lys Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Asn Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Glu Arg Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Asn Lys Met Met Leu Val Lys Lys Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Ala Arg Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Glu His Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asn Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Asn Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 199
<211> 531
<212> PRT
<213> African swine fever virus
<400> 199
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Val Gln Gln His Thr Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asn Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asp Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys Tyr Arg Leu Glu Asn Asp Leu
145 150 155 160
Pro Leu Ala His Leu Leu Val Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Leu Tyr Glu Asn Leu His Ile Tyr Asn Ile Met
180 185 190
Glu Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Arg
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
Tyr Leu Asp Val Leu Ile Leu Ser Gly Leu His Leu Leu Tyr Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Asn Asp Asn Leu Asp Ile Ile Leu Thr Gln Ala Val Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Tyr Ile Pro Gln Leu Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Met Ala Ile Lys Lys Lys Ser Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Lys Leu Ser Ile Lys Leu
305 310 315 320
Ile Lys Lys Ile Ser Gln Tyr Val Ala Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Gly Ile Leu Asn Met Lys Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Phe Val Lys Tyr Ala Ile Phe Asn Lys Tyr Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Ile Lys Met
370 375 380
Ala Ala Arg Ile Asn Lys Met Leu Leu Val Lys Lys Ile Ser Gln His
385 390 395 400
Ala Trp Lys Asn His Ala Ala Arg Leu Lys His Leu Lys His Ala Val
405 410 415
Tyr Thr Met Lys His Lys Asp Gly Lys Asn Arg Leu Met Asn Leu Ile
420 425 430
Tyr Asp His Tyr Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Leu Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Gly Lys Asn Ala His Asp Ala Thr Asn Ile
485 490 495
Thr Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu
500 505 510
Ser Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His
515 520 525
Tyr Met Pro
530
<210> 200
<211> 530
<212> PRT
<213> African swine fever virus
<400> 200
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Arg Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Val Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Asn Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asn Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Met Met
115 120 125
Arg Arg Cys Phe Phe Asn Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Ser Val Leu Leu Tyr Phe Lys Tyr Ile Leu Lys Glu Asn Leu
145 150 155 160
Pro Leu Val His Ser Leu Ile Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Glu Ile Met
180 185 190
Asp Thr Phe Lys Cys Ala Ile Ala His Lys Asp Leu His Leu Tyr Ser
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
His Leu Asp Ile Arg Ile Leu Ser Arg Leu Gln Leu Leu His Lys Val
225 230 235 240
Thr Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Lys Asp Asn Ile Asn Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Asn Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Val Ala Ile Lys Thr Asn Ala Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Val Lys Lys Leu Ser Gln Tyr Val Val Ala Tyr Lys Ser Thr Asn Ile
325 330 335
Ile Ser Ile Leu Ser Met Gln Gln Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Val Val Lys Asn Ala Ile Phe Ile Lys Phe Val Ile
355 360 365
Gly Cys Met Val Thr Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Lys Lys Met Lys Leu Val Lys Asn Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Ala Lys Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Gln Glu Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp His Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser Tyr Ile Ile Ala Lys Asn Ala His Asp Ala Ser Ile Asn
485 490 495
Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu Ser
500 505 510
Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys Asp Tyr
515 520 525
Met Leu
530
<210> 201
<211> 530
<212> PRT
<213> African swine fever virus
<400> 201
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Val Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Asn Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn His His
85 90 95
Asn Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Thr Met
115 120 125
Arg Arg Cys Phe Phe Asn Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Ser Val Leu Leu Tyr Phe Lys Tyr Ile Leu Lys Glu Asn Leu
145 150 155 160
Pro Leu Val His Ser Leu Ile Glu Lys Ala Tyr Lys Tyr His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asp Ile Ile
180 185 190
Asn Thr Phe Lys Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Val Tyr Asn Arg Ile Val Pro Tyr Lys Tyr Tyr
210 215 220
His Leu Asp Ile Arg Ile Leu Leu Arg Leu Gln Leu Leu His Lys Val
225 230 235 240
Thr Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Thr Asn Asn Ile Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Asn Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Val Ala Ile Lys Thr Asn Ala Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Val Lys Lys Leu Ser Gln Tyr Val Val Ala Tyr Lys Ser Thr Asn Ile
325 330 335
Ile Ser Ile Leu Ser Arg Gln Gln Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Val Val Lys Asn Ala Val Phe Asn Lys Phe Val Ile
355 360 365
Gly Cys Met Val Thr Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Lys Lys Met Lys Leu Val Lys Asn Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Val Lys Leu Lys Tyr Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Gln Glu Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp His Cys Tyr Tyr His Met Gln Glu Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Val Lys Asn Ala His Asp Ala Ser Ile Asn
485 490 495
Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu Ser
500 505 510
Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys Asp Tyr
515 520 525
Met Leu
530
<210> 202
<211> 530
<212> PRT
<213> African swine fever virus
<400> 202
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Asp Tyr Val Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Asn Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg His
85 90 95
Asn Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Val Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asn Cys Met Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Ser Val Leu Leu Tyr Phe Lys Tyr Ile Leu Lys Glu Asn Leu
145 150 155 160
Pro Leu Val His Ser Leu Ile Glu Lys Ala Tyr Lys Tyr His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ile Tyr Asp Ile Ile
180 185 190
Asn Thr Phe Lys Tyr Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Val Tyr Asn Arg Ile Val Pro Tyr Lys Tyr Tyr
210 215 220
His Leu Asp Ile Arg Ile Leu Leu Arg Leu Gln Leu Leu His Lys Val
225 230 235 240
Thr Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Thr Asn Asn Ile Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Asn Ile Leu Thr Tyr Phe Ile Pro Gln Ser Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Phe Val Ala Ile Lys Thr Asn Ala Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Val Lys Lys Leu Ser Gln Tyr Val Val Ala Tyr Lys Ser Thr Asn Ile
325 330 335
Ile Ser Ile Leu Ser Met Gln Gln Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Lys Val Val Lys Asn Ala Val Phe Ile Lys Phe Val Ile
355 360 365
Gly Cys Met Val Thr Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Lys Lys Met Lys Leu Val Lys Asn Ile Ser Glu His
385 390 395 400
Val Trp Lys Asn His Ala Ala Lys Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Gln Glu Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp His Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Ser Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Ile Leu Asp Thr Ile Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Ser His Ile Ile Ala Lys Asn Ala His Asp Ala Ser Ile Asn
485 490 495
Ile Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu Ser
500 505 510
Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys Tyr Asp
515 520 525
Ile Leu
530
<210> 203
<211> 530
<212> PRT
<213> African swine fever virus
<400> 203
Met Phe Ser Leu Gln Asn Leu Cys Arg Lys Thr Leu Pro Asp Cys Lys
1 5 10 15
Leu Pro Glu Phe Phe Asp Glu Tyr Ile Leu Gln Leu Leu Gly Leu Tyr
20 25 30
Trp Glu Asn His Gly Thr Ile Gln Arg Ala Gly Asn Asn Cys Val Leu
35 40 45
Ile Gln Gln His Asn Leu Ile Pro Val Asn Glu Ala Leu Arg Ile Ala
50 55 60
Ala Ser Glu Glu Asn Tyr Glu Ile Val Ser Leu Leu Leu Ala Trp Glu
65 70 75 80
Gly Asn Leu Tyr Tyr Ala Ile Ile Gly Ala Leu Glu Gly Asn Arg Pro
85 90 95
Asp Leu Ile Arg Lys Tyr Asp Asp Gln Ile Lys Asp His His Glu Ile
100 105 110
Leu Pro Phe Ile Asp Asp Pro Ile Ile Phe His Lys Cys His Ile Met
115 120 125
Arg Arg Cys Phe Phe Asn Cys Ile Leu Tyr Gln Ala Val Lys Tyr Ser
130 135 140
Lys Phe Arg Val Leu Leu Tyr Phe Lys His Arg Leu Gly Asp Asp Leu
145 150 155 160
Pro Leu Thr His Leu Leu Ile Glu Lys Ala Cys Glu Asp His Asn Tyr
165 170 175
Glu Val Ile Lys Trp Ile Tyr Glu Asn Leu His Ser Tyr Asn Ile Met
180 185 190
Asp Thr Phe Glu Cys Ala Ile Ala His Lys Asp Leu Arg Leu Tyr Cys
195 200 205
Leu Gly Tyr Thr Phe Ile Tyr Asn Arg Ile Val Pro Tyr Lys Tyr His
210 215 220
His Leu Asp Ile Cys Ile Leu Ser Ser Leu Gln Leu Leu His Lys Val
225 230 235 240
Ala Ala Lys Gly Tyr Leu Asp Phe Ile Leu Glu Thr Leu Lys Tyr Asp
245 250 255
His Asn Ile Asn Asn Ile Asp Ile Ile Leu Thr Gln Ala Ala Thr Tyr
260 265 270
Asn His Arg Lys Ile Leu Thr Tyr Phe Ile Pro Gln Leu Thr Tyr Ala
275 280 285
Gln Ile Glu Gln Cys Leu Leu Val Ala Ile Lys Thr Lys Ala Ser Lys
290 295 300
Lys Thr Leu Asn Leu Leu Leu Ser His Leu Asn Leu Ser Ile Lys Leu
305 310 315 320
Ile Lys Lys Ile Ser Gln Tyr Val Val Thr Tyr Asn Ser Thr Asn Ile
325 330 335
Ile Ser Ile Leu Ser Met Arg Arg Lys Lys Lys Ile Tyr Leu Asp Ile
340 345 350
Ile Leu Thr Glu Phe Val Lys Asn Ala Ile Phe Asn Lys Phe Val Val
355 360 365
Arg Cys Met Asp Thr Phe Ser Ile Asn Pro Glu Arg Ile Val Lys Met
370 375 380
Ala Ala Arg Ile Asn Arg Met Met Leu Val Lys Asn Ile Ser Glu Arg
385 390 395 400
Val Trp Lys Asn His Ala Val Lys Leu Lys His Leu Lys His Ala Val
405 410 415
His Thr Met Lys His Gln Glu Gly Lys Asn Arg Leu Met Asn Phe Ile
420 425 430
Tyr Asp His Cys Tyr Tyr His Met Gln Gly Glu Glu Ile Phe Gly Leu
435 440 445
Ala Arg Phe Tyr Ala Ile His His Ala Pro Lys Leu Phe Asp Val Phe
450 455 460
Tyr Asp Cys Cys Met Leu Asp Ala Thr Arg Phe Lys Ser Leu Leu Leu
465 470 475 480
Asp Cys Pro His Ile Ile Gly Lys Asn Ala Tyr Asp Ala Gly Ile Asn
485 490 495
Leu Val Asn Lys Tyr Ile Gly Asn Leu Phe Ala Met Gly Val Leu Ser
500 505 510
Lys Lys Glu Ile Leu Gln Asp Tyr Pro Ser Ile Tyr Ser Lys His Asp
515 520 525
Met Phe
530
<210> 204
<211> 462
<212> DNA
<213> African swine fever virus
<400> 204
atgtatttta agaaaaaata catcggtctt attgataaga actgtgaaaa aaaaatatta 60
gatgattcta gtacaataaa aatttgttac atattaattg gaatattgat tggaactaat 120
atgataactc ttatttataa tttcatattc tgggataatt atataaaatg ttaccgaaat 180
aatgataaaa tgttttactg tcctaatgat tgggttggat ataataatat ttgttactat 240
tttagtaatg gtagtttttc taaaaattat acagctgcta gtaatttttg tagacaatta 300
aatggtacac ttgctaataa tgatactaat ttattaaatc taactaaaat atataataat 360
caatctatgt attgggttaa caatacggta atattacgtg gtgataataa atatagtcaa 420
aaagttaact atacagattt attatttatt tgtggtaaat aa 462
<210> 205
<211> 477
<212> DNA
<213> African swine fever virus
<400> 205
atgttttcta acaaaaagta catcggtctt atcaataaga aggagggttt gaaaaaaaaa 60
atagatgatt atagtatatt aataattgga atattaattg gaactaacat cttaagcctt 120
attataaata taataggaga gattaataaa ccaatatgtt accaaaatga tgataagata 180
ttttattgcc ctaaagattg ggttggatat aataatgttt gttattattt tggcaatgaa 240
gaaaaaaatt ataataatgc aagtaattat tgtaagcaat taaatagtac gcttactaat 300
aataatacta ttttagtaaa tcttactaaa acattaaatc ttactaaaac atataatcac 360
gaatctaatt attgggttaa ttattcttta attaaaaatg agtcagtact attacgtgat 420
agtggatatt acaaaaaaca aaaacatgta agtttattat atatttgtag taaataa 477
<210> 206
<211> 495
<212> DNA
<213> African swine fever virus
<400> 206
atgtattcta agaaaaagta catcggtctt attgacaaga actgtgaaaa aaaaatatta 60
gatgatgcta ctacaataaa aatttgttac atattaattg gaatattgat tggaactaat 120
attataactc ttatctataa tttcatattt tgggagaatt atataaaatg tatccaaaat 180
gatgataaga tgttttactg tcctaaagat tgggttgggt ataataatgc gtgttattat 240
tttagtaata acaataaaaa ttatacagat gcaaataatt attgtaaaaa ttcacataat 300
agtacacttg ctaataatga tactaaatta ttaaatctta ctaaattatt aaatctttct 360
aaattatatt acaatgattc tacatattgg gttaaatatt ctttacctaa aaataaagca 420
gtaacattac gtaacagtac ctacaaatat gatagagtta aatctacaga aacatttttt 480
atttgtagta actaa 495
<210> 207
<211> 498
<212> DNA
<213> African swine fever virus
<400> 207
atgtattcta agaaaaagta catcggtctt attgacaaaa gctgtgaaaa aaaaatatta 60
gatgatccta ctacaataaa aatttgttac atattaattg gaatattgat tggaactaat 120
attataactc ttatctataa tttcatattt tgggagaatt atataaaatg tatccgaaat 180
gatgataaga tgttttactg ccctaaagat tgggttggat ataataatgt gtgttattat 240
tttagtaacg ataatggaaa aaattatatg aatgcaagta atttttgtaa taaaaaaaat 300
agcacgcttg ctaataatac gactaattta gtaaatctta ctaaaatatt aaattttacc 360
aaacaatata atcatgaatc actttattgg gttaattatt ctttaagtaa taatatgtca 420
ttagcattac agaatagtaa ttttccttct tcaggaagac gtaaatatat ggacttatta 480
tatatatgta gtatataa 498
<210> 208
<211> 462
<212> DNA
<213> African swine fever virus
<400> 208
atgtatttta agaaaaaata catcggtctt attgataaga actgtgaaaa aaaaatatta 60
gatgattcta gtacaataaa aatttgttac atattaattg gaatattgat tggaactaat 120
atgataactc ttatttataa tttcatattc tgggataatt atataaaatg ttaccgaaat 180
aatgataaaa tgttttactg tcctaatgat tgggttggat ataataatat ttgttactat 240
tttagtaatg gtagtttttc taaaaattat acagctgcta gtaatttttg tagacaatta 300
aatggtacac ttgctaataa tgatactaat ttattaaatc taactaaaat atataataat 360
caatctatgt attgggttaa caatacggta atattacgtg gtgataataa atatagtcaa 420
aaagttaact atacagattt attatttatt tgtggtaaat aa 462
<210> 209
<211> 477
<212> DNA
<213> African swine fever virus
<400> 209
atgttttcta acaaaaagta catcggtctt atcaataaga aggagggttt gaaaaaaaaa 60
atagatgatt atagtatatt aataattgga atattaattg gaactaacat cttaagcctt 120
attataaata taataggaga gattaataaa ccaatatgtt accaaaatga tgataagata 180
ttttattgcc ctaaagattg ggttggatat aataatgttt gttattattt tggcaatgaa 240
gaaaaaaatt ataataatgc aagtaattat tgtaagcaat taaatagtac gcttactaat 300
aataatacta ttttagtaaa tcttactaaa acattaaatc ttactaaaac atataatcac 360
gaatctaatt attgggttaa ttattcttta attaaaaatg agtcagtact attacgtgat 420
agtggatatt acaaaaaaca aaaacatgta agtttattat atatttgtag taaataa 477
<210> 210
<211> 486
<212> DNA
<213> African swine fever virus
<400> 210
atgttttcta acaaaaagta catcggtctt attgacaagt actgtgaaaa aaaaatatta 60
gatgattcta gtacaataaa aatttgttac atattaattg gaatactgat tggaactaat 120
atgataactc ttatttataa tttcatattt tgggagaatt atataacatg taaccaaaaa 180
gataagacgt tttactgtcc taaagattgg gttggatata ataatgtttg ttattatttt 240
ggcaatgatg aaaaaaatta taataatgca agtaattatt gtaagcaatt aaatagtacg 300
cttactaata ataatactaa tttagtaaat cttactaaaa cattaaatct tactaaaaca 360
tataatcacg aatctaatta ttgggttaat tattctttaa ttaaaaatga gtcagtacta 420
ttacgcaata gtggatatta taaaaaacaa aaacatgtaa gtttattata tatttgtagt 480
aaataa 486
<210> 211
<211> 492
<212> DNA
<213> African swine fever virus
<400> 211
atgttttcta ataaaaagta cattggtctt atcaataaga aggagggatt gaaaaaaaaa 60
atagatgatt atagtatatt aataattgga atattaattg gaactaacat cttaagcctt 120
attataaata taataggaga gattaataaa ccaatatgtt accaaaataa tgataagata 180
ttttattgcc ctaaagattg ggttggatat aataatgttt gttattattt tagtaatgat 240
aatggcaata attatacaac tgcggataat aaatgtaaac aattaaataa tagtacactg 300
gctaataatc ttactgattt attaaatctt acgagtttct taaatcttac taaattatat 360
catcatcatt ctcattattg ggttaattat tctttaaata ataattattc agtaccatta 420
attgatagta aatataattt aaataggaaa aaaagtcact atacagattt actatttatt 480
tgcagcaaat aa 492
<210> 212
<211> 465
<212> DNA
<213> African swine fever virus
<400> 212
atgtatttta agaaaaaata catcggtctt attgataaga actgtgaaaa aaaaatatta 60
gatgattcta gtacaataaa aatttgttac atattaattg gaatattgat tggaactaat 120
atgataactc ttatttataa tttcatattc tgggataatt atataaaatg ttaccgaaat 180
aatgataaaa tgttttactg tcctaatgat tgggttggat ataataatgt ttgttactat 240
tttagtaatg gtagtttttt taaaaattat acagatgcta ataattattg taaaaaaata 300
aatagtactc ttgctaataa tgatactaat ttattaagtt taactaaaat atacaataat 360
caatctatgt attgggttaa caatacagta gcattacgtg gtgatagtgt atatgcacaa 420
agaaaagtta ataattcaga tctattattt atttgtagta aataa 465
<210> 213
<211> 465
<212> DNA
<213> African swine fever virus
<400> 213
atgtatttta agaaaaagta catcggtctt attgataaga actgtgaaaa aaaaatatta 60
gatgattgta ctacaataaa aatttgttac atattaattg gaatattgat tggaactaat 120
atgataactc ttatttataa tttcatattt tgggatcatt atatgacatg taacaaaaaa 180
gataagatgt tttactgtcc taaagattgg gttggatata ataatgtttg ttattatttt 240
agtaatgata gttttactaa gaattataca tatgcaagta attcttgtaa aaaaataaat 300
agtacacttg ctaataatga tactaattta ctaaatctta ttaaagtata taataatgta 360
tctgagtatt gggttaataa tacagtaaca ttacgtggtg atcataaata cataaataag 420
caaaataatt gtaatacaga atttttattt atttgtagta gatag 465
<210> 214
<211> 471
<212> DNA
<213> African swine fever virus
<400> 214
atgttttcta acaaaaagta tccgagtctt atcgaaaaaa aaatggatga cttgatgact 60
ttaaagtttt gttacatcat tattgcaatc ttgatcatga ctaatatttt tagccttgtt 120
gtgaatatat gggggggggg tgatcgacaa tcttatgaga atgtatttta ttgtcctaaa 180
gattgggttg gatataataa tgcatgttat tattttagta atgatatgaa aaattataca 240
gaagcaagta attattgtaa aaatttatat aatagtacaa ttgttaataa taatactaat 300
atagtaaatc ttactaaaac attaaatctt actaaaatat ataatcatga aagtaattat 360
tgggttaatt attctttaat taataatgag tcattaacat tacgggacag taattttcct 420
tcttcaggaa aacgtacata tatagattta ttatatatat gtagtatata a 471
<210> 215
<211> 468
<212> DNA
<213> African swine fever virus
<400> 215
atgtatttta agaaaaagta catcggtctt attgataaga actgtgaaaa aaaaatatta 60
gatgattgta ctacaataaa aatttgttac atattaattg gaatattgat tggaactaat 120
atgataactc ttatttataa tttcatattt tgggatcatt atatgacatg taacaaaaaa 180
gataagatgt tttactgtcc taaagattgg gttggatata ataatgtttg ttattatttt 240
aataatgata gtaagaatta tacaactgct actaattctt gtaaacaatt aaatagtaca 300
cttgctaata atgatactaa tttattaaat cttactaaag tatatcacca tgataaatta 360
tattgggtta actattcttt aaatgacaat ttttcattat cattacgtaa tagtacatat 420
gaaaaaagat ctaaatattt gccattatta tttatttgca gtaaataa 468
<210> 216
<211> 477
<212> DNA
<213> African swine fever virus
<400> 216
atgtttttga acaaaaagta tccgagtctt atcgaaaaaa aaatggatga tttgatgact 60
ttaaagtttt gttacttaat aatcacattt ttaatcataa ccaatatttt tagccttgct 120
ataaatatat gggggggggg tgatatgata gatcgacaaa gttgtgaaaa tatattttac 180
tgtcctaaag attgggttgg ctataataat gcgtgttatt attttagtaa taacaataaa 240
aattatacag atgcaaataa ttattgtaaa aattcacata atagtacact tgctaataat 300
gatactaaat tattaaatct tactaaatta ttaaatcttt ctaaattata ttacaatgat 360
tctacatatt gggttaaata ttctttacct aaaaataaag cagtaacatt acgtaacagt 420
acctacaaat atgatagagt taaatataca gaaacatttt ttatttgtag taactaa 477
<210> 217
<211> 158
<212> PRT
<213> African swine fever virus
<400> 217
Met Phe Ser Asn Lys Lys Tyr Ile Gly Leu Ile Asn Lys Lys Glu Gly
1 5 10 15
Leu Lys Lys Lys Ile Asp Asp Tyr Ser Ile Leu Ile Ile Gly Ile Leu
20 25 30
Ile Gly Thr Asn Ile Leu Ser Leu Ile Ile Asn Ile Ile Gly Glu Ile
35 40 45
Asn Lys Pro Ile Cys Tyr Gln Asn Asp Asp Lys Ile Phe Tyr Cys Pro
50 55 60
Lys Asp Trp Val Gly Tyr Asn Asn Val Cys Tyr Tyr Phe Gly Asn Glu
65 70 75 80
Glu Lys Asn Tyr Asn Asn Ala Ser Asn Tyr Cys Lys Gln Leu Asn Ser
85 90 95
Thr Leu Thr Asn Asn Asn Thr Ile Leu Val Asn Leu Thr Lys Thr Leu
100 105 110
Asn Leu Thr Lys Thr Tyr Asn His Glu Ser Asn Tyr Trp Val Asn Tyr
115 120 125
Ser Leu Ile Lys Asn Glu Ser Val Leu Leu Arg Asp Ser Gly Tyr Tyr
130 135 140
Lys Lys Gln Lys His Val Ser Leu Leu Tyr Ile Cys Ser Lys
145 150 155
<210> 218
<211> 164
<212> PRT
<213> African swine fever virus
<400> 218
Met Tyr Ser Lys Lys Lys Tyr Ile Gly Leu Ile Asp Lys Asn Cys Glu
1 5 10 15
Lys Lys Ile Leu Asp Asp Ala Thr Thr Ile Lys Ile Cys Tyr Ile Leu
20 25 30
Ile Gly Ile Leu Ile Gly Thr Asn Ile Ile Thr Leu Ile Tyr Asn Phe
35 40 45
Ile Phe Trp Glu Asn Tyr Ile Lys Cys Ile Gln Asn Asp Asp Lys Met
50 55 60
Phe Tyr Cys Pro Lys Asp Trp Val Gly Tyr Asn Asn Ala Cys Tyr Tyr
65 70 75 80
Phe Ser Asn Asn Asn Lys Asn Tyr Thr Asp Ala Asn Asn Tyr Cys Lys
85 90 95
Asn Ser His Asn Ser Thr Leu Ala Asn Asn Asp Thr Lys Leu Leu Asn
100 105 110
Leu Thr Lys Leu Leu Asn Leu Ser Lys Leu Tyr Tyr Asn Asp Ser Thr
115 120 125
Tyr Trp Val Lys Tyr Ser Leu Pro Lys Asn Lys Ala Val Thr Leu Arg
130 135 140
Asn Ser Thr Tyr Lys Tyr Asp Arg Val Lys Ser Thr Glu Thr Phe Phe
145 150 155 160
Ile Cys Ser Asn
<210> 219
<211> 165
<212> PRT
<213> African swine fever virus
<400> 219
Met Tyr Ser Lys Lys Lys Tyr Ile Gly Leu Ile Asp Lys Ser Cys Glu
1 5 10 15
Lys Lys Ile Leu Asp Asp Pro Thr Thr Ile Lys Ile Cys Tyr Ile Leu
20 25 30
Ile Gly Ile Leu Ile Gly Thr Asn Ile Ile Thr Leu Ile Tyr Asn Phe
35 40 45
Ile Phe Trp Glu Asn Tyr Ile Lys Cys Ile Arg Asn Asp Asp Lys Met
50 55 60
Phe Tyr Cys Pro Lys Asp Trp Val Gly Tyr Asn Asn Val Cys Tyr Tyr
65 70 75 80
Phe Ser Asn Asp Asn Gly Lys Asn Tyr Met Asn Ala Ser Asn Phe Cys
85 90 95
Asn Lys Lys Asn Ser Thr Leu Ala Asn Asn Thr Thr Asn Leu Val Asn
100 105 110
Leu Thr Lys Ile Leu Asn Phe Thr Lys Gln Tyr Asn His Glu Ser Leu
115 120 125
Tyr Trp Val Asn Tyr Ser Leu Ser Asn Asn Met Ser Leu Ala Leu Gln
130 135 140
Asn Ser Asn Phe Pro Ser Ser Gly Arg Arg Lys Tyr Met Asp Leu Leu
145 150 155 160
Tyr Ile Cys Ser Ile
165
<210> 220
<211> 153
<212> PRT
<213> African swine fever virus
<400> 220
Met Tyr Phe Lys Lys Lys Tyr Ile Gly Leu Ile Asp Lys Asn Cys Glu
1 5 10 15
Lys Lys Ile Leu Asp Asp Ser Ser Thr Ile Lys Ile Cys Tyr Ile Leu
20 25 30
Ile Gly Ile Leu Ile Gly Thr Asn Met Ile Thr Leu Ile Tyr Asn Phe
35 40 45
Ile Phe Trp Asp Asn Tyr Ile Lys Cys Tyr Arg Asn Asn Asp Lys Met
50 55 60
Phe Tyr Cys Pro Asn Asp Trp Val Gly Tyr Asn Asn Ile Cys Tyr Tyr
65 70 75 80
Phe Ser Asn Gly Ser Phe Ser Lys Asn Tyr Thr Ala Ala Ser Asn Phe
85 90 95
Cys Arg Gln Leu Asn Gly Thr Leu Ala Asn Asn Asp Thr Asn Leu Leu
100 105 110
Asn Leu Thr Lys Ile Tyr Asn Asn Gln Ser Met Tyr Trp Val Asn Asn
115 120 125
Thr Val Ile Leu Arg Gly Asp Asn Lys Tyr Ser Gln Lys Val Asn Tyr
130 135 140
Thr Asp Leu Leu Phe Ile Cys Gly Lys
145 150
<210> 221
<211> 158
<212> PRT
<213> African swine fever virus
<400> 221
Met Phe Ser Asn Lys Lys Tyr Ile Gly Leu Ile Asn Lys Lys Glu Gly
1 5 10 15
Leu Lys Lys Lys Ile Asp Asp Tyr Ser Ile Leu Ile Ile Gly Ile Leu
20 25 30
Ile Gly Thr Asn Ile Leu Ser Leu Ile Ile Asn Ile Ile Gly Glu Ile
35 40 45
Asn Lys Pro Ile Cys Tyr Gln Asn Asp Asp Lys Ile Phe Tyr Cys Pro
50 55 60
Lys Asp Trp Val Gly Tyr Asn Asn Val Cys Tyr Tyr Phe Gly Asn Glu
65 70 75 80
Glu Lys Asn Tyr Asn Asn Ala Ser Asn Tyr Cys Lys Gln Leu Asn Ser
85 90 95
Thr Leu Thr Asn Asn Asn Thr Ile Leu Val Asn Leu Thr Lys Thr Leu
100 105 110
Asn Leu Thr Lys Thr Tyr Asn His Glu Ser Asn Tyr Trp Val Asn Tyr
115 120 125
Ser Leu Ile Lys Asn Glu Ser Val Leu Leu Arg Asp Ser Gly Tyr Tyr
130 135 140
Lys Lys Gln Lys His Val Ser Leu Leu Tyr Ile Cys Ser Lys
145 150 155
<210> 222
<211> 161
<212> PRT
<213> African swine fever virus
<400> 222
Met Phe Ser Asn Lys Lys Tyr Ile Gly Leu Ile Asp Lys Tyr Cys Glu
1 5 10 15
Lys Lys Ile Leu Asp Asp Ser Ser Thr Ile Lys Ile Cys Tyr Ile Leu
20 25 30
Ile Gly Ile Leu Ile Gly Thr Asn Met Ile Thr Leu Ile Tyr Asn Phe
35 40 45
Ile Phe Trp Glu Asn Tyr Ile Thr Cys Asn Gln Lys Asp Lys Thr Phe
50 55 60
Tyr Cys Pro Lys Asp Trp Val Gly Tyr Asn Asn Val Cys Tyr Tyr Phe
65 70 75 80
Gly Asn Asp Glu Lys Asn Tyr Asn Asn Ala Ser Asn Tyr Cys Lys Gln
85 90 95
Leu Asn Ser Thr Leu Thr Asn Asn Asn Thr Asn Leu Val Asn Leu Thr
100 105 110
Lys Thr Leu Asn Leu Thr Lys Thr Tyr Asn His Glu Ser Asn Tyr Trp
115 120 125
Val Asn Tyr Ser Leu Ile Lys Asn Glu Ser Val Leu Leu Arg Asn Ser
130 135 140
Gly Tyr Tyr Lys Lys Gln Lys His Val Ser Leu Leu Tyr Ile Cys Ser
145 150 155 160
Lys
<210> 223
<211> 163
<212> PRT
<213> African swine fever virus
<400> 223
Met Phe Ser Asn Lys Lys Tyr Ile Gly Leu Ile Asn Lys Lys Glu Gly
1 5 10 15
Leu Lys Lys Lys Ile Asp Asp Tyr Ser Ile Leu Ile Ile Gly Ile Leu
20 25 30
Ile Gly Thr Asn Ile Leu Ser Leu Ile Ile Asn Ile Ile Gly Glu Ile
35 40 45
Asn Lys Pro Ile Cys Tyr Gln Asn Asn Asp Lys Ile Phe Tyr Cys Pro
50 55 60
Lys Asp Trp Val Gly Tyr Asn Asn Val Cys Tyr Tyr Phe Ser Asn Asp
65 70 75 80
Asn Gly Asn Asn Tyr Thr Thr Ala Asp Asn Lys Cys Lys Gln Leu Asn
85 90 95
Asn Ser Thr Leu Ala Asn Asn Leu Thr Asp Leu Leu Asn Leu Thr Ser
100 105 110
Phe Leu Asn Leu Thr Lys Leu Tyr His His His Ser His Tyr Trp Val
115 120 125
Asn Tyr Ser Leu Asn Asn Asn Tyr Ser Val Pro Leu Ile Asp Ser Lys
130 135 140
Tyr Asn Leu Asn Arg Lys Lys Ser His Tyr Thr Asp Leu Leu Phe Ile
145 150 155 160
Cys Ser Lys
<210> 224
<211> 154
<212> PRT
<213> African swine fever virus
<400> 224
Met Tyr Phe Lys Lys Lys Tyr Ile Gly Leu Ile Asp Lys Asn Cys Glu
1 5 10 15
Lys Lys Ile Leu Asp Asp Ser Ser Thr Ile Lys Ile Cys Tyr Ile Leu
20 25 30
Ile Gly Ile Leu Ile Gly Thr Asn Met Ile Thr Leu Ile Tyr Asn Phe
35 40 45
Ile Phe Trp Asp Asn Tyr Ile Lys Cys Tyr Arg Asn Asn Asp Lys Met
50 55 60
Phe Tyr Cys Pro Asn Asp Trp Val Gly Tyr Asn Asn Val Cys Tyr Tyr
65 70 75 80
Phe Ser Asn Gly Ser Phe Phe Lys Asn Tyr Thr Asp Ala Asn Asn Tyr
85 90 95
Cys Lys Lys Ile Asn Ser Thr Leu Ala Asn Asn Asp Thr Asn Leu Leu
100 105 110
Ser Leu Thr Lys Ile Tyr Asn Asn Gln Ser Met Tyr Trp Val Asn Asn
115 120 125
Thr Val Ala Leu Arg Gly Asp Ser Val Tyr Ala Gln Arg Lys Val Asn
130 135 140
Asn Ser Asp Leu Leu Phe Ile Cys Ser Lys
145 150
<210> 225
<211> 154
<212> PRT
<213> African swine fever virus
<400> 225
Met Tyr Phe Lys Lys Lys Tyr Ile Gly Leu Ile Asp Lys Asn Cys Glu
1 5 10 15
Lys Lys Ile Leu Asp Asp Cys Thr Thr Ile Lys Ile Cys Tyr Ile Leu
20 25 30
Ile Gly Ile Leu Ile Gly Thr Asn Met Ile Thr Leu Ile Tyr Asn Phe
35 40 45
Ile Phe Trp Asp His Tyr Met Thr Cys Asn Lys Lys Asp Lys Met Phe
50 55 60
Tyr Cys Pro Lys Asp Trp Val Gly Tyr Asn Asn Val Cys Tyr Tyr Phe
65 70 75 80
Ser Asn Asp Ser Phe Thr Lys Asn Tyr Thr Tyr Ala Ser Asn Ser Cys
85 90 95
Lys Lys Ile Asn Ser Thr Leu Ala Asn Asn Asp Thr Asn Leu Leu Asn
100 105 110
Leu Ile Lys Val Tyr Asn Asn Val Ser Glu Tyr Trp Val Asn Asn Thr
115 120 125
Val Thr Leu Arg Gly Asp His Lys Tyr Ile Asn Lys Gln Asn Asn Cys
130 135 140
Asn Thr Glu Phe Leu Phe Ile Cys Ser Arg
145 150
<210> 226
<211> 156
<212> PRT
<213> African swine fever virus
<400> 226
Met Phe Ser Asn Lys Lys Tyr Pro Ser Leu Ile Glu Lys Lys Met Asp
1 5 10 15
Asp Leu Met Thr Leu Lys Phe Cys Tyr Ile Ile Ile Ala Ile Leu Ile
20 25 30
Met Thr Asn Ile Phe Ser Leu Val Val Asn Ile Trp Gly Gly Gly Asp
35 40 45
Arg Gln Ser Tyr Glu Asn Val Phe Tyr Cys Pro Lys Asp Trp Val Gly
50 55 60
Tyr Asn Asn Ala Cys Tyr Tyr Phe Ser Asn Asp Met Lys Asn Tyr Thr
65 70 75 80
Glu Ala Ser Asn Tyr Cys Lys Asn Leu Tyr Asn Ser Thr Ile Val Asn
85 90 95
Asn Asn Thr Asn Ile Val Asn Leu Thr Lys Thr Leu Asn Leu Thr Lys
100 105 110
Ile Tyr Asn His Glu Ser Asn Tyr Trp Val Asn Tyr Ser Leu Ile Asn
115 120 125
Asn Glu Ser Leu Thr Leu Arg Asp Ser Asn Phe Pro Ser Ser Gly Lys
130 135 140
Arg Thr Tyr Ile Asp Leu Leu Tyr Ile Cys Ser Ile
145 150 155
<210> 227
<211> 155
<212> PRT
<213> African swine fever virus
<400> 227
Met Tyr Phe Lys Lys Lys Tyr Ile Gly Leu Ile Asp Lys Asn Cys Glu
1 5 10 15
Lys Lys Ile Leu Asp Asp Cys Thr Thr Ile Lys Ile Cys Tyr Ile Leu
20 25 30
Ile Gly Ile Leu Ile Gly Thr Asn Met Ile Thr Leu Ile Tyr Asn Phe
35 40 45
Ile Phe Trp Asp His Tyr Met Thr Cys Asn Lys Lys Asp Lys Met Phe
50 55 60
Tyr Cys Pro Lys Asp Trp Val Gly Tyr Asn Asn Val Cys Tyr Tyr Phe
65 70 75 80
Asn Asn Asp Ser Lys Asn Tyr Thr Thr Ala Thr Asn Ser Cys Lys Gln
85 90 95
Leu Asn Ser Thr Leu Ala Asn Asn Asp Thr Asn Leu Leu Asn Leu Thr
100 105 110
Lys Val Tyr His His Asp Lys Leu Tyr Trp Val Asn Tyr Ser Leu Asn
115 120 125
Asp Asn Phe Ser Leu Ser Leu Arg Asn Ser Thr Tyr Glu Lys Arg Ser
130 135 140
Lys Tyr Leu Pro Leu Leu Phe Ile Cys Ser Lys
145 150 155
<210> 228
<211> 158
<212> PRT
<213> African swine fever virus
<400> 228
Met Phe Leu Asn Lys Lys Tyr Pro Ser Leu Ile Glu Lys Lys Met Asp
1 5 10 15
Asp Leu Met Thr Leu Lys Phe Cys Tyr Leu Ile Ile Thr Phe Leu Ile
20 25 30
Ile Thr Asn Ile Phe Ser Leu Ala Ile Asn Ile Trp Gly Gly Gly Asp
35 40 45
Met Ile Asp Arg Gln Ser Cys Glu Asn Ile Phe Tyr Cys Pro Lys Asp
50 55 60
Trp Val Gly Tyr Asn Asn Ala Cys Tyr Tyr Phe Ser Asn Asn Asn Lys
65 70 75 80
Asn Tyr Thr Asp Ala Asn Asn Tyr Cys Lys Asn Ser His Asn Ser Thr
85 90 95
Leu Ala Asn Asn Asp Thr Lys Leu Leu Asn Leu Thr Lys Leu Leu Asn
100 105 110
Leu Ser Lys Leu Tyr Tyr Asn Asp Ser Thr Tyr Trp Val Lys Tyr Ser
115 120 125
Leu Pro Lys Asn Lys Ala Val Thr Leu Arg Asn Ser Thr Tyr Lys Tyr
130 135 140
Asp Arg Val Lys Tyr Thr Glu Thr Phe Phe Ile Cys Ser Asn
145 150 155
<210> 229
<211> 1083
<212> DNA
<213> African swine fever virus
<400> 229
atgataatac ttattttttt aatattttct aacatagttt taagtattga ttattgggtt 60
agttttaata aaacaataat tttagatagt aatattacta atgataataa tgatataaat 120
ggagtatcat ggaatttttt taataattct tttaatacac tagctacatg tggaaaagca 180
ggtaactttt gtgaatgttc taattatagt acatcaatat ataatataac aaataattgt 240
agcttaacta tttttcctca taatgatgta tttgatacaa catatcaagt agtatggaat 300
caaataatta attatacaat aaaattatta acacctgcta ctcccccaaa tatcacatat 360
aattgtacta attttttaat aacatgtaaa aaaaataatg gaacaaacac taatatatat 420
ttaaatataa atgatacttt tgttaaatat actaatgaaa gtatacttga atataactgg 480
aataatagta acattaacaa ttttacagct acatgtataa ttaataatac aattagtaca 540
tctaatgaaa caacacttat aaattgtact tatttaacat tgtcatctaa ctatttttat 600
acttttttta aattatatta tattccatta agcatcataa ttgggataac aataagtatt 660
cttcttatat ccatcataac ttttttatct ttacgaaaaa gaaaaaaaca tgttgaagaa 720
atagaaagtc caccacctga atctaatgaa gaagaacaat gtcagcatga tgacaccact 780
tccatacatg aaccatctcc cagagaacca ttacttccta agccttacag tcgttatcag 840
tataatacac ctatttacta catgcgtccc tcaacacaac cactcaaccc atttccctta 900
cctaaaccgt gtcctccacc caaaccatgt ccgccaccca aaccatgtcc tccacctaaa 960
ccatgtcctt cagctgaatc ctattctcca cccaaaccac tacctagtat cccgctacta 1020
cccaatatcc cgccattatc tacccaaaat atttcgctta ttcacgtaga tagaattatt 1080
taa 1083
<210> 230
<211> 1083
<212> DNA
<213> African swine fever virus
<400> 230
atgataatac ttattttttt aatattttct aacatagttt taagtattga ttattgggtt 60
agttttaata aaacaataat tttagatagt aatattacta atgataataa tgatataaat 120
ggagtatcat ggaatttttt taataattct tttaatacac tagctacatg tggaaaagca 180
ggtaactttt gtgaatgttc taattatagt acatcaatat ataatataac aaataattgt 240
agcttaacta tttttcctca taatgatgta tttgatacaa catatcaagt agtatggaat 300
caaataatta attatacaat aaaattatta acacctgcta ctcccccaaa tatcacatat 360
aattgtacta attttttaat aacatgtaaa aaaaataatg gaacaaacac taatatatat 420
ttaaatataa atgatacttt tgttaaatat actaatgaaa gtatacttga atataactgg 480
aataatagta acattaacaa ttttacagct acatgtataa ttaataatac aattagtaca 540
tctaatgaaa caacacttat aaattgtact tatttaacat tgtcatctaa ctatttttat 600
acttttttta aattatatta tattccatta agcatcataa ttgggataac aataagtatt 660
cttcttatat ccatcataac ttttttatct ttacgaaaaa gaaaaaaaca tgttgaagaa 720
atagaaagtc caccacctga atctaatgaa gaagaacaat gtcagcatga tgacaccact 780
tccatacatg aaccatctcc cagagaacca ttacttccta agccttacag tcgttatcag 840
tataatacac ctatttacta catgcgtccc tcaacacaac cactcaaccc atttccctta 900
cctaaaccgt gtcctccacc caaaccatgt ccgccaccca aaccatgtcc tccacctaaa 960
ccatgtcctt cagctgaatc ctattctcca cccaaaccac tacctagtat cccgctacta 1020
cccaatatcc cgccattatc tacccaaaat atttcgctta ttcacgtaga tagaattatt 1080
taa 1083
<210> 231
<211> 1170
<212> DNA
<213> African swine fever virus
<400> 231
atgataataa tccttatttt tttaatatat ttaaaactgg tcttaaataa taatattatt 60
atatggcatc ctactttaaa tgaaacaatt tttttaaatg ttacaactat agggaatatt 120
agtggtctat tttggaatac atattataat aataatcgta gtgaacttac taagtgcgga 180
atatataata attattgttc atgtgatagt cttaatacat cattgtataa tataaataat 240
tgtagtttag ttatttttcc aaataataca aaaatattta atacaatata tgaattaata 300
tattcaggta atcaaactaa ttatacaata aaattgctag aatctactac tcctccaaat 360
attacatata attgtactac atctgtaata acatgtaaaa aaaataatgg gacaaatact 420
aatatatttt taactataaa taatacgatt gttaattcta ctaatgaaga tgttatttac 480
tactattgga atagaagtga atttaataac tttacagcta catgtatgat taataataca 540
attaattcat caaatatatc agaaattata gactgtacta atacattatt attaaacagt 600
tatttagact tttttcaagt agccggttat atgttttata tgataatttt tattgtaact 660
ggaataacag taagtatttt tatttcaatc ataacttttt tatctttacg aaaaagaaaa 720
aaacatgttg aagaaataga aagtctacca cctgaatcta atgaagaaga atgtcagcat 780
gatgatgaca ccacttccat acatgaacca tcccccagag aaccattact tcctaaacct 840
tacagtcgtt atcagtataa tacacctatt tactacatgc gtccctcaac acaaccactc 900
aacccatttc ccctacctaa accatgccca ccacctaaac cgtgtccgcc acccaaacca 960
tgtcctccac ccaaaccatg cccgccaccc aaaccatgcc cgccacctaa accatgtcct 1020
ccacctgaat catgttcttc acctgaatca tgttcttcac ctgaatcata ttctccaccc 1080
aaaccactac ctagtatccc gctgctaccc aatatcccgc cattatctac acaaaatatt 1140
tcgcttattc atgtagatag aattatttaa 1170
<210> 232
<211> 1221
<212> DNA
<213> African swine fever virus
<400> 232
atgataatgt tcataacact tattttttta agttatatta atatagtttt aagtaataat 60
tattgggcta gacttaacga aacaataact ttaaatagta acattactaa tgatactaat 120
aatgaattag gtatattttg gaattcttat aataatactt attataataa tacatttaat 180
aatattgcta tatgtggaaa aaaaggtatt ttttgtgaat gtaatattaa ttataataca 240
tctatatcta atacatctat atctaataca tcaatatata atgtaacaaa taattgtagt 300
ttaacgattt ttctttatga tgataatata tttaaaacat atcaattagt atatcagaat 360
tacaaaatta attatacaat aaacttatta ttacctgtta cttctccaaa tattacatat 420
aattgtacta actctttaat aacatgtgaa aaaaatgatg ggacaaacac taatatgttt 480
ttatctataa ataatataac cattaatcat actaatcaag atattcttac ttactattgg 540
aataatagtg agtttaataa ttttacagct acatgtatga ttaataatac acttaattca 600
gcaaatacca caaaagttat caattgcact aatccattat taaattctta ccaaaattat 660
tttcttgaaa atattcatac attattttat atcataattt ttattgtgag tggattaata 720
gcaagtattt ttatttcaat tataactttt ttatctttac gaaaaagaaa aaaacatgtt 780
gaagaaatag aaagtccacc acctgaatct aatgaagaag aacaatgtca gcatgatgac 840
accacttcca tacatgaacc atctcccaga gaaccattac ttcctaaacc ttacagtcgt 900
tatcaatata atacacctat ttactacatg cgtccctcaa cacaaccact caacccattt 960
cccctaccta acccatgtcc tccacctaaa ccgtgtcctc cacccaaacc atgcccgcca 1020
cctaaaccat gtcccccacc caaaccatgc ccgccaccta aaccgtgtcc tccacccaaa 1080
ccatgtccac cacctaaacc atgttcttca cctgaatcat attctccacc caaaccacta 1140
cctagtatcc cgctactacc caatatccca ccattatcta cacaaaatat ttcacttatt 1200
catgtagata gaattattta a 1221
<210> 233
<211> 1122
<212> DNA
<213> African swine fever virus
<400> 233
atgataataa tagttatttt tttaatgtgt ttaaaaatag ttttaaacaa tattataata 60
tggagtactt taaatcaaac tgtattttta aataatattt ttacaattaa tgatacatat 120
ggtggtctat tttggaatac atattatgat aataatcgta gtaattttac ttattgtgga 180
atagcaggaa attattgttc atgttgtggt cataacatat cattgtataa tacaacaaat 240
aattgtagtt taattatttt tcctaacaat acagaaatat ttaatagaac atatgaatta 300
gtatatttgg acaaaaaaat taattataca gtaaaactat taaaatctgt tgattcccca 360
actattacat ataattgtac taattcttta ataacatgta aaaataataa tgggacaaat 420
gttaatatat atttaattat taataataca attagttcat tgaatgaaac agaaaatata 480
aattgtacta atccaatatt aaaatatcaa aattatttat ccacattatt ttatatcata 540
atttttattg tgagtggatt aataataggt atttttattt caatcatatc tgtattatct 600
atacgaagaa aaagaaaaaa acatgttgaa gaaatagaaa gtccaccacc ctctgaatct 660
aatgaagaag atatttctca cgatgacacc acttccatac atgaaccatc tcccagagaa 720
ccattacttc ctaagcctta cagtcgttat cagtataata cacctattta ctacatgcgt 780
ccctcaacac aaccactcaa cccatttccc ctacctaaac catgcccgcc acctaaacca 840
tgtcctccac ccaagccatg cccgccaccc aaaccatgtc ctccacctaa accgtgttct 900
ccacccaaac cgtgtcgtcc acctaaacca tgtcctccac ctaaaccatg tcctccacct 960
aaaccatgtc ctccacctaa accatgtcct ccatccaaac catgtccttc acctgaatcc 1020
tattctccac ccaaaccact acctagtatc ccgttactac ccaatatccc gccattatct 1080
acacaaaata tttcgcttat tcatgtagat agaattattt aa 1122
<210> 234
<211> 1209
<212> DNA
<213> African swine fever virus
<400> 234
atgataataa tagttatttt tttaatgtgt ttaaaaatag ttttaaacaa tattataata 60
tggagtactt taaatcaaac tgtattttta aataatattt ttacaattaa tgatacatat 120
ggtggtctat tttggaatac atattatgat aataatcgta gtaattttac ttattgtgga 180
atagcaggaa attattgttc atgttgtggt cataacatat cattgtataa tacaacaaat 240
aattgtagtt taattatttt tcctaacaat acagaaatat ttaatagaac atatgaatta 300
gtatatttgg acaaaaaaat taattataca gtaaaactat taaaatctgt tgattcccca 360
actattacat ataattgtac taattcttta ataacatgta aaaataataa tgggacaaat 420
gttaatatat atttaattat taacaataca attgttaatg atactaatgg agatatcctt 480
aattattatt ggaatggtaa taataatttt acagctacat gtatgattaa taatacaatt 540
agttcattga atgaaacaga aaatataaat tgtactaatc caatattaaa atatcaaaat 600
tatttatcca cattatttta tatcataatt tttattgtga gtggattaat aataggtatt 660
tttatttcaa tcatatctgt attatctata cgaagaaaaa gaaaaaaaca tgttgaagaa 720
atagaaagtc caccaccctc tgaatctaat gaagaagata tttctcacga tgacaccact 780
tccatacatg aaccatctcc cagagaacca ttacttccta agccttacag tcgttatcag 840
tataatacac ctatttacta catgcgtccc tcaacacaac cactcaaccc atttccccta 900
cctaaaccat gcccgccacc taaaccatgt cctccaccca agccatgccc gccacccaaa 960
ccatgtcctc cacctaaacc gtgttctcca cccaaaccgt gtcgtccacc taaaccatgt 1020
cctccaccta aaccatgtcc tccacctaaa ccatgtcctc cacctaaacc atgtcctcca 1080
tccaaaccat gtccttcacc tgaatcctat tctccaccca aaccactacc tagtatcccg 1140
ttactaccca atatcccgcc attatctaca caaaatattt cgcttattca tgtagataga 1200
attatttaa 1209
<210> 235
<211> 1149
<212> DNA
<213> African swine fever virus
<400> 235
atgataataa aggttatttt tttagttttc tttaaaatgg ttttaagtaa tattataata 60
tggagtactt taaataacac aatatattta aatattaatt attcagatag taatttatat 120
actggtctat tttggaataa atattataat aatactcgta ataattttac tacttgtgta 180
acatcaaata gtagctattg tacatgtaaa ggccataaca catcattgta taatataaca 240
aataattgta gtttaatcat ttttccaaat aatacaaaaa tatttaatac aacatatgaa 300
ttagtatatt taaataataa aattaattat acaatacaaa tggtacaacc tgttgatcct 360
ccaattatta tatataatga tactaataat tctttaataa catgtgaaaa aaataatgga 420
acgaatactg aaatctattt atatttaaat gatacattta ttaataatac taatgaaaat 480
agtattaaat actattggaa ttgtagcgaa ttaaaccata atattacaac tacatgtatt 540
attaataata cacttaattc ggcaaatacc acaaaagtta taaattgcac taatctattg 600
ttaaaatctg accaaaatta ttttcttaaa aatattcata cattatttta tatcataatt 660
tttattgtgg gtggaacatt aataagcatt attatatcaa tcataacttt tttatcttta 720
cgaaaaagaa aaaaacatgt tgaagaaata gaaagtccac caccctctga atctaatgaa 780
gaagaacatt gtcagcatga tgataccact tccatacatg aaccatctcc cagagaacca 840
ttacttccta agccttacag tcgttatcag tataatacac ctatttacta catgcgtccc 900
tcaacacaac cactcaaccc atttccccta cctaaaccat gtcctccacc taaaccgtgt 960
cctccaccca aaccatgtcc tccacctaaa ccgtgtcctc cacctaaacc gtgtccccca 1020
cctaaaccat gtccttcacc tgaatcccat tctccaccca aaccactacc tagtatcccg 1080
ctgctaccca atattccccc attatctaca caaaatattt cgcttattca tgtagataga 1140
attatttaa 1149
<210> 236
<211> 1128
<212> DNA
<213> African swine fever virus
<400> 236
atgataataa tacttatttt tttaataatt cctaacatag ttttaagtat tgattattgg 60
gttagtttta ataaaacaat aattttagat agtaatatta ctaatgataa taatgatata 120
aatggagtat catggaattt ccttaataat tctcttaata cactagctac atgtggaaaa 180
gcaggtaact tttgtgaatg ctctaattat agtacatcac tatataatat agcacataat 240
tgtagcttaa ctattttccc tcataatgat gtatttggta caccatatca agtagtatgg 300
aatcaaataa ttaattatac aataaaatta ttaacacctg ttactccccc aaatattaca 360
tataattgta ctaatttttt aataacatgt aaaaaaaata atggaacaaa tactattata 420
tatttcaata taaatgatac taatgttaaa tatactaatg aaagtatact tgaatataac 480
tggaataata gtaactttaa caattttaca gctacatgta taattaataa tacaattaat 540
tcatcaaatg atacacaaac tatagactgc atcaatacat tattaagcag ttatttagac 600
ttttttcaag tagccagtta tatgttttat atgataattt ttattgcaac tggaataata 660
gcaagtattt ttatatcaat cataactttt ttatctttac gaaaaagaaa aaaacatgtt 720
gaagaaatag aaagtccatc gccatctgaa tctaatgaag aagaacaatg tcagcatgat 780
gacaccactt ccatacatga accgtctccc agagaaccat tacttcctaa gccttacagt 840
cgatatcagt ataatacacc tatttactat atgcgtccct taacacaacc actcaatcca 900
tctcccctac ccaaactgtg tcctccaccc aaaccgtgtc ctccacccaa accgtgtcct 960
ccacccaaac cgtgtcctcc acccaaaccg tgtccttcat ctgaatcatg ttctccacct 1020
gaatcatatt ctctacccaa accactacct aatatcccgc tactacccaa tatcccgcca 1080
ttatctacac aaaatatctc gcttattcac gtagatagaa ttatttaa 1128
<210> 237
<211> 1158
<212> DNA
<213> African swine fever virus
<400> 237
atgataataa agcttatttt tttaatatca tttaaaatga ttttaggtat tgattattgg 60
gttagtctta ataatacaat aattttagat agtaacatta ctattaataa tattactaat 120
actactaata atcctacatt aaatggtata ttttggaata tttataataa tagttataat 180
aatactttta atttacttac cacatgtggg aatacatata atatatgttc ttgttctaat 240
aattataata caatattatt taattataat accacaaata attgtagttt aattatttct 300
cctcatgatg aaaaaatttt tgatacgatg tttcagataa tatatttaac taataaaatt 360
aattatacaa tacgatggtt acaacctgtt gatcccccaa atatttcatt taatgatagt 420
aattctttaa taaaatgtga aaaaaataat ggaacaaata ctgaaatcta tttatattta 480
aatgatacat ttattaataa tactaatgaa aatgatctta aatattattg gaattgtagt 540
gagttaaact ataatattac agctacatgt attattaata atacacttaa ttcggcaaat 600
accacaaaag ttataaattg cactaatcta ttattaaaat ctgaccaaaa ttattttctt 660
aaaaacattc atacattatt ttatatcata atttttattg taactgggat aataataagt 720
atttttatag caatcataac ttttttatct ttacgaaaaa gaaaaaaaca tgttgaagaa 780
atagaaagtc catcgcctga atctaatgaa gaggaagaac aacaacatca tcatgacact 840
acttccatac atgaaccgtc tcccagagaa ccattacttc ctaagcctta cagtcgttat 900
cagtataata cacctattta ttacatgcgt ccctcaacac aacaactatt taaatcatat 960
tctttaccca aaccatgtcc cccacctaaa ccatgtcctc cacctaaacc atgtccccca 1020
cccaaaccat gtccctcacc agaatcatat ccctcacctg aaccatatcc tctactacct 1080
aatatcccac taccacccaa tatcccgcca ttatctacac aaaatatttc gcttattcac 1140
gtagatagaa ttatttaa 1158
<210> 238
<211> 1143
<212> DNA
<213> African swine fever virus
<400> 238
atgataataa aacttatttt tttaatttgt tttaaaatag ttttaagtat tgataataaa 60
acaaaattta atgaaacatt aattttagat aatattgatt attgggtaaa gtttaatgat 120
acaataactt tagatagtaa tattactagt gaaatagaag ctgtatcttg gaatttttat 180
aataatactt ttaatctact tgctacatgt ggaaaagcaa gtaacttttg tagttgttct 240
aattatagta catcattttt taatattaca aataattgta gtttaactat ttttttaata 300
gacgagacgt tatttaatac aacatatcaa atagtatatt caactaatat aattaattat 360
aaaataaact tattaatacc tgttactcct ccaattattt catataattg tactaattgt 420
tctataaatt gtaaaaaaag taatggtaca aatactaata tttttttatc tataaatgat 480
acaattgtta catatactaa tgaaagtatt cttaattatg attataactg tagtatttta 540
aataataatt ttacagttac atgtataatt aataatacaa ttagtacatc aaatactaca 600
gaatttataa actgcactaa tatattatta agtagttatc tagatttttt tcaagtaact 660
agttatatat tttatatgat aatttttatt gtaactggaa taacagtaag tattcttata 720
tccatcataa ctttcttatt tatacgaaaa agaaaacatg ttgaagaaat agaaagtcca 780
ccgcctgaat ctaatgaaga agaacaacaa tgtcatcatg acaccacttc tatacatgaa 840
ccgtctccca gagaaccatt acttcctaag ccttacagtc gttatcaata taatacacct 900
atttactaca tgcgtccctc aacacaacaa ctatttaaat catattcttt acccaaacca 960
tgtcccccac ctaaaccatg tcctccaccc aaaccatgtc ccccacccaa accatgtcct 1020
ccacccaaac catgtcctcc atccaaacca tatccttcac tacctagtat cccgctacca 1080
cccgatatcc cgccattatc tacacaaaat atttcgctta ttcacgtaga tagaattatt 1140
taa 1143
<210> 239
<211> 1179
<212> DNA
<213> African swine fever virus
<400> 239
atgataataa aacttatttt tttaatttgt tttaaaatag ttttaagtat tgataataaa 60
acaaaattta atgaaacatt aattttagat aatattgatt attgggtaaa gtttaatgat 120
acaataactt tagatagtaa tattactagt gaaatagaag ctgtatcttg gaatttttat 180
aataatactt ttaatctact tgctatatgt ggaaaagcaa gtaacttttg tagttgttct 240
aattatagta catcattttt taatattaca aataattgta gtttaactat ttttttaata 300
gacgagacgt tatttaatac aacatatcaa atagtatatt caactaatat aattaattat 360
aaaataaact tattaatacc tgttactcct ccaattattt catataattg tgctaattgt 420
tctataaatt gtaaaaaaag taatggtaca aatactaata tttttttatc tataaatgat 480
acaattgtta catatactaa tgaaagtatt cttaattatg attataactg tagtatttta 540
aataataatt ttacagttac atgtataatt aataatacaa ttagcacatc aaatactaca 600
gaatttataa actgcactaa tatattatta agtagttatc tagatttttt tcaagtaact 660
agttatatat tttatatgat aatttttatt gtaactggaa taacagtaag tattcttata 720
tccatcataa ctttcttatt tatacgaaaa agaaaacatg ttgaagaaat agaaagtcca 780
ccgcctgaat ctaatgaaga agaacaacaa tgtcatcatg acaccacttc tatacatgaa 840
ccgtctccca gagaaccatt acttcctaag ccttacagtc gttatcaata taatacacct 900
atttactaca tgcgtccctc aacacaacaa ctatttaaat catattcttt acccaaacca 960
tgtcccccac ctaaaccatg tcctccacct aaaccatgtc ccccacctaa accatgtcct 1020
ccatccaaac catgtcctcc acctgaacca tattctccac ccaaaccatg tcctccaccc 1080
aaaccatatc cttcactacc tagtatcccg ctaccacccg atatcccgcc attatctaca 1140
caaaatattt cgcttattca cgtagataga attatttaa 1179
<210> 240
<211> 1146
<212> DNA
<213> African swine fever virus
<400> 240
atgataatta aacttatttt tttaatttgt ttcaaaatag ttttaagtat taattattgg 60
gttaggtata atgatacagt aactttaaat agtaatatca atagcgagac agaaggtata 120
ttttggaatt tttataataa tacttttaat actattgcca catgtggaaa aaaaaataat 180
gtttgtgaat gttctaatta tgataaatcc ttatataata taacaaataa ttgtagttta 240
acaatttttc caaataatac aaaaatattt aatacaacat atcaattagt atattcacgc 300
aatagaatta attacacaat aaatttgtta ttacctgtta catctccaat tattacatat 360
aattgtactc aatctttaat aacatgtgaa aaaactaatg gaacaaatat tcatttattc 420
ttaaatttaa atgatacaat taatgaatat actaacaaaa gttttctcaa ttactattgg 480
aatagtagtg agttaaataa tatttttctt gctacatgta ttattaataa tacacttaat 540
tcagcaaata ctacaaaagt tatcaattgc actaacccat tattaaaatc ttaccaaaat 600
tattttcttg aaaatattca tacattattt tatatgataa tttttattgt atctggaata 660
acaataagta tttttatatc aatcataact tttttatctt tacgaaaaag aaaaaaacat 720
gttgaagaaa tagagagtcc accacctgaa tctaatgaag aagaacaatg tcagcatgat 780
gacaccactt ctatacatga accatctccc agagaaccat tacttcctaa accttacagt 840
cgttatcagt ataatacacc tatttactac atgcgtccct caacacaacc actcaaccca 900
tttcccctac ctaaaccatg cccgccacct aaaccgtgtc ctccacccaa accatgcccg 960
ccacccaaac catgcccgcc acctaaacca tgtcctccac ccaaaccatg cccgccacct 1020
aaaccatgtc ctccacctga atcatattct ccacccaaac cactacctag tatcccgctg 1080
ctacccaata tcccgccatt atctacacaa aatatttcgc ttattcatgt agatagaatt 1140
atttaa 1146
<210> 241
<211> 1182
<212> DNA
<213> African swine fever virus
<400> 241
atgatgataa ttatacttat ttttttaata tgtttaaaaa tagttttaaa taataatatt 60
ataatatggc atactttaaa tgaaacaatt tttttaaata atagtattac atttacggat 120
aatcttggtg gtctattttg gaatacatat tataataata atcatagtat ccttactagt 180
tgcggaatat atcaaaatta ttgttcatgc actaataatt atagcacatc attatataat 240
ataacaaata attgtggttt aataattttt ccaaataata caaaaagatt taacacaacg 300
tatgaattag tatatttaaa taatagtact aaatatacaa taaacttatt agtacctgtt 360
actcctccaa atattacata taattgtact acatctgtaa taacatgtaa aaaaaatgat 420
ggcacaaata ctaatatgtt tttaaaaata aatgatacaa tcgttaaaag tagtaatgaa 480
agtgtttttg aatactcttg gaatagtact gatttaaata acaattttac ggctatatgt 540
ataattaata atacaattaa ttcatcaaat gacacacaaa ctatagaatg tcccaatata 600
ttattaaaca attatttaga cttttttcaa gtaactagtt acatgtttta tatgataatt 660
tttattgtaa ctggaataat agcaagtatt tttatttcaa tcataacttt tttatcttta 720
cgaaaaagaa aaaaacatgt tgaagaaata gaaagtccac caccctctga atctaatgaa 780
gaagatattt ctcacgatga caccacttcc atacatgaac catctcccag agaaccatta 840
cttcctaagc cttacagtcg ttatcagtat aatacaccta tttactacat gcgtccctca 900
acacaaccac tcaacccatt tcccctacct aaaccatgcc cgccacctaa accatgcccg 960
ccacccaaac catgtcctcc acctaaaccg tgtcctccac ccaaaccgtg tcgtccacct 1020
aaaccatgtc ctccacctaa accatgccca ccacctaaac catgtccttc acctgaaaca 1080
tattctccac ccaaaccact acctaatatc ccgctgctac ccaatatccc gccattatct 1140
acacaaaata tttcgcttat tcacgtagat aggattattt aa 1182
<210> 242
<211> 360
<212> PRT
<213> African swine fever virus
<400> 242
Met Ile Ile Leu Ile Phe Leu Ile Phe Ser Asn Ile Val Leu Ser Ile
1 5 10 15
Asp Tyr Trp Val Ser Phe Asn Lys Thr Ile Ile Leu Asp Ser Asn Ile
20 25 30
Thr Asn Asp Asn Asn Asp Ile Asn Gly Val Ser Trp Asn Phe Phe Asn
35 40 45
Asn Ser Phe Asn Thr Leu Ala Thr Cys Gly Lys Ala Gly Asn Phe Cys
50 55 60
Glu Cys Ser Asn Tyr Ser Thr Ser Ile Tyr Asn Ile Thr Asn Asn Cys
65 70 75 80
Ser Leu Thr Ile Phe Pro His Asn Asp Val Phe Asp Thr Thr Tyr Gln
85 90 95
Val Val Trp Asn Gln Ile Ile Asn Tyr Thr Ile Lys Leu Leu Thr Pro
100 105 110
Ala Thr Pro Pro Asn Ile Thr Tyr Asn Cys Thr Asn Phe Leu Ile Thr
115 120 125
Cys Lys Lys Asn Asn Gly Thr Asn Thr Asn Ile Tyr Leu Asn Ile Asn
130 135 140
Asp Thr Phe Val Lys Tyr Thr Asn Glu Ser Ile Leu Glu Tyr Asn Trp
145 150 155 160
Asn Asn Ser Asn Ile Asn Asn Phe Thr Ala Thr Cys Ile Ile Asn Asn
165 170 175
Thr Ile Ser Thr Ser Asn Glu Thr Thr Leu Ile Asn Cys Thr Tyr Leu
180 185 190
Thr Leu Ser Ser Asn Tyr Phe Tyr Thr Phe Phe Lys Leu Tyr Tyr Ile
195 200 205
Pro Leu Ser Ile Ile Ile Gly Ile Thr Ile Ser Ile Leu Leu Ile Ser
210 215 220
Ile Ile Thr Phe Leu Ser Leu Arg Lys Arg Lys Lys His Val Glu Glu
225 230 235 240
Ile Glu Ser Pro Pro Pro Glu Ser Asn Glu Glu Glu Gln Cys Gln His
245 250 255
Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu Pro Leu Leu
260 265 270
Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile Tyr Tyr Met
275 280 285
Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe Pro Leu Pro Lys Pro Cys
290 295 300
Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
305 310 315 320
Pro Cys Pro Ser Ala Glu Ser Tyr Ser Pro Pro Lys Pro Leu Pro Ser
325 330 335
Ile Pro Leu Leu Pro Asn Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser
340 345 350
Leu Ile His Val Asp Arg Ile Ile
355 360
<210> 243
<211> 406
<212> PRT
<213> African swine fever virus
<400> 243
Met Ile Met Phe Ile Thr Leu Ile Phe Leu Ser Tyr Ile Asn Ile Val
1 5 10 15
Leu Ser Asn Asn Tyr Trp Ala Arg Leu Asn Glu Thr Ile Thr Leu Asn
20 25 30
Ser Asn Ile Thr Asn Asp Thr Asn Asn Glu Leu Gly Ile Phe Trp Asn
35 40 45
Ser Tyr Asn Asn Thr Tyr Tyr Asn Asn Thr Phe Asn Asn Ile Ala Ile
50 55 60
Cys Gly Lys Lys Gly Ile Phe Cys Glu Cys Asn Ile Asn Tyr Asn Thr
65 70 75 80
Ser Ile Ser Asn Thr Ser Ile Ser Asn Thr Ser Ile Tyr Asn Val Thr
85 90 95
Asn Asn Cys Ser Leu Thr Ile Phe Leu Tyr Asp Asp Asn Ile Phe Lys
100 105 110
Thr Tyr Gln Leu Val Tyr Gln Asn Tyr Lys Ile Asn Tyr Thr Ile Asn
115 120 125
Leu Leu Leu Pro Val Thr Ser Pro Asn Ile Thr Tyr Asn Cys Thr Asn
130 135 140
Ser Leu Ile Thr Cys Glu Lys Asn Asp Gly Thr Asn Thr Asn Met Phe
145 150 155 160
Leu Ser Ile Asn Asn Ile Thr Ile Asn His Thr Asn Gln Asp Ile Leu
165 170 175
Thr Tyr Tyr Trp Asn Asn Ser Glu Phe Asn Asn Phe Thr Ala Thr Cys
180 185 190
Met Ile Asn Asn Thr Leu Asn Ser Ala Asn Thr Thr Lys Val Ile Asn
195 200 205
Cys Thr Asn Pro Leu Leu Asn Ser Tyr Gln Asn Tyr Phe Leu Glu Asn
210 215 220
Ile His Thr Leu Phe Tyr Ile Ile Ile Phe Ile Val Ser Gly Leu Ile
225 230 235 240
Ala Ser Ile Phe Ile Ser Ile Ile Thr Phe Leu Ser Leu Arg Lys Arg
245 250 255
Lys Lys His Val Glu Glu Ile Glu Ser Pro Pro Pro Glu Ser Asn Glu
260 265 270
Glu Glu Gln Cys Gln His Asp Asp Thr Thr Ser Ile His Glu Pro Ser
275 280 285
Pro Arg Glu Pro Leu Leu Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn
290 295 300
Thr Pro Ile Tyr Tyr Met Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe
305 310 315 320
Pro Leu Pro Asn Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
325 330 335
Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro
340 345 350
Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys
355 360 365
Ser Ser Pro Glu Ser Tyr Ser Pro Pro Lys Pro Leu Pro Ser Ile Pro
370 375 380
Leu Leu Pro Asn Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser Leu Ile
385 390 395 400
His Val Asp Arg Ile Ile
405
<210> 244
<211> 373
<212> PRT
<213> African swine fever virus
<400> 244
Met Ile Ile Ile Val Ile Phe Leu Met Cys Leu Lys Ile Val Leu Asn
1 5 10 15
Asn Ile Ile Ile Trp Ser Thr Leu Asn Gln Thr Val Phe Leu Asn Asn
20 25 30
Ile Phe Thr Ile Asn Asp Thr Tyr Gly Gly Leu Phe Trp Asn Thr Tyr
35 40 45
Tyr Asp Asn Asn Arg Ser Asn Phe Thr Tyr Cys Gly Ile Ala Gly Asn
50 55 60
Tyr Cys Ser Cys Cys Gly His Asn Ile Ser Leu Tyr Asn Thr Thr Asn
65 70 75 80
Asn Cys Ser Leu Ile Ile Phe Pro Asn Asn Thr Glu Ile Phe Asn Arg
85 90 95
Thr Tyr Glu Leu Val Tyr Leu Asp Lys Lys Ile Asn Tyr Thr Val Lys
100 105 110
Leu Leu Lys Ser Val Asp Ser Pro Thr Ile Thr Tyr Asn Cys Thr Asn
115 120 125
Ser Leu Ile Thr Cys Lys Asn Asn Asn Gly Thr Asn Val Asn Ile Tyr
130 135 140
Leu Ile Ile Asn Asn Thr Ile Ser Ser Leu Asn Glu Thr Glu Asn Ile
145 150 155 160
Asn Cys Thr Asn Pro Ile Leu Lys Tyr Gln Asn Tyr Leu Ser Thr Leu
165 170 175
Phe Tyr Ile Ile Ile Phe Ile Val Ser Gly Leu Ile Ile Gly Ile Phe
180 185 190
Ile Ser Ile Ile Ser Val Leu Ser Ile Arg Arg Lys Arg Lys Lys His
195 200 205
Val Glu Glu Ile Glu Ser Pro Pro Pro Ser Glu Ser Asn Glu Glu Asp
210 215 220
Ile Ser His Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu
225 230 235 240
Pro Leu Leu Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile
245 250 255
Tyr Tyr Met Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe Pro Leu Pro
260 265 270
Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro
275 280 285
Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Ser Pro Pro Lys Pro
290 295 300
Cys Arg Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro
305 310 315 320
Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Ser Lys Pro Cys Pro
325 330 335
Ser Pro Glu Ser Tyr Ser Pro Pro Lys Pro Leu Pro Ser Ile Pro Leu
340 345 350
Leu Pro Asn Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser Leu Ile His
355 360 365
Val Asp Arg Ile Ile
370
<210> 245
<211> 385
<212> PRT
<213> African swine fever virus
<400> 245
Met Ile Ile Lys Leu Ile Phe Leu Ile Ser Phe Lys Met Ile Leu Gly
1 5 10 15
Ile Asp Tyr Trp Val Ser Leu Asn Asn Thr Ile Ile Leu Asp Ser Asn
20 25 30
Ile Thr Ile Asn Asn Ile Thr Asn Thr Thr Asn Asn Pro Thr Leu Asn
35 40 45
Gly Ile Phe Trp Asn Ile Tyr Asn Asn Ser Tyr Asn Asn Thr Phe Asn
50 55 60
Leu Leu Thr Thr Cys Gly Asn Thr Tyr Asn Ile Cys Ser Cys Ser Asn
65 70 75 80
Asn Tyr Asn Thr Ile Leu Phe Asn Tyr Asn Thr Thr Asn Asn Cys Ser
85 90 95
Leu Ile Ile Ser Pro His Asp Glu Lys Ile Phe Asp Thr Met Phe Gln
100 105 110
Ile Ile Tyr Leu Thr Asn Lys Ile Asn Tyr Thr Ile Arg Trp Leu Gln
115 120 125
Pro Val Asp Pro Pro Asn Ile Ser Phe Asn Asp Ser Asn Ser Leu Ile
130 135 140
Lys Cys Glu Lys Asn Asn Gly Thr Asn Thr Glu Ile Tyr Leu Tyr Leu
145 150 155 160
Asn Asp Thr Phe Ile Asn Asn Thr Asn Glu Asn Asp Leu Lys Tyr Tyr
165 170 175
Trp Asn Cys Ser Glu Leu Asn Tyr Asn Ile Thr Ala Thr Cys Ile Ile
180 185 190
Asn Asn Thr Leu Asn Ser Ala Asn Thr Thr Lys Val Ile Asn Cys Thr
195 200 205
Asn Leu Leu Leu Lys Ser Asp Gln Asn Tyr Phe Leu Lys Asn Ile His
210 215 220
Thr Leu Phe Tyr Ile Ile Ile Phe Ile Val Thr Gly Ile Ile Ile Ser
225 230 235 240
Ile Phe Ile Ala Ile Ile Thr Phe Leu Ser Leu Arg Lys Arg Lys Lys
245 250 255
His Val Glu Glu Ile Glu Ser Pro Ser Pro Glu Ser Asn Glu Glu Glu
260 265 270
Glu Gln Gln His His His Asp Thr Thr Ser Ile His Glu Pro Ser Pro
275 280 285
Arg Glu Pro Leu Leu Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr
290 295 300
Pro Ile Tyr Tyr Met Arg Pro Ser Thr Gln Gln Leu Phe Lys Ser Tyr
305 310 315 320
Ser Leu Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
325 330 335
Pro Cys Pro Pro Pro Lys Pro Cys Pro Ser Pro Glu Ser Tyr Pro Ser
340 345 350
Pro Glu Pro Tyr Pro Leu Leu Pro Asn Ile Pro Leu Pro Pro Asn Ile
355 360 365
Pro Pro Leu Ser Thr Gln Asn Ile Ser Leu Ile His Val Asp Arg Ile
370 375 380
Ile
385
<210> 246
<211> 380
<212> PRT
<213> African swine fever virus
<400> 246
Met Ile Ile Lys Leu Ile Phe Leu Ile Cys Phe Lys Ile Val Leu Ser
1 5 10 15
Ile Asp Asn Lys Thr Lys Phe Asn Glu Thr Leu Ile Leu Asp Asn Ile
20 25 30
Asp Tyr Trp Val Lys Phe Asn Asp Thr Ile Thr Leu Asp Ser Asn Ile
35 40 45
Thr Ser Glu Ile Glu Ala Val Ser Trp Asn Phe Tyr Asn Asn Thr Phe
50 55 60
Asn Leu Leu Ala Thr Cys Gly Lys Ala Ser Asn Phe Cys Ser Cys Ser
65 70 75 80
Asn Tyr Ser Thr Ser Phe Phe Asn Ile Thr Asn Asn Cys Ser Leu Thr
85 90 95
Ile Phe Leu Ile Asp Glu Thr Leu Phe Asn Thr Thr Tyr Gln Ile Val
100 105 110
Tyr Ser Thr Asn Ile Ile Asn Tyr Lys Ile Asn Leu Leu Ile Pro Val
115 120 125
Thr Pro Pro Ile Ile Ser Tyr Asn Cys Thr Asn Cys Ser Ile Asn Cys
130 135 140
Lys Lys Ser Asn Gly Thr Asn Thr Asn Ile Phe Leu Ser Ile Asn Asp
145 150 155 160
Thr Ile Val Thr Tyr Thr Asn Glu Ser Ile Leu Asn Tyr Asp Tyr Asn
165 170 175
Cys Ser Ile Leu Asn Asn Asn Phe Thr Val Thr Cys Ile Ile Asn Asn
180 185 190
Thr Ile Ser Thr Ser Asn Thr Thr Glu Phe Ile Asn Cys Thr Asn Ile
195 200 205
Leu Leu Ser Ser Tyr Leu Asp Phe Phe Gln Val Thr Ser Tyr Ile Phe
210 215 220
Tyr Met Ile Ile Phe Ile Val Thr Gly Ile Thr Val Ser Ile Leu Ile
225 230 235 240
Ser Ile Ile Thr Phe Leu Phe Ile Arg Lys Arg Lys His Val Glu Glu
245 250 255
Ile Glu Ser Pro Pro Pro Glu Ser Asn Glu Glu Glu Gln Gln Cys His
260 265 270
His Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu Pro Leu Leu
275 280 285
Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile Tyr Tyr Met
290 295 300
Arg Pro Ser Thr Gln Gln Leu Phe Lys Ser Tyr Ser Leu Pro Lys Pro
305 310 315 320
Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro
325 330 335
Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Ser Lys Pro Tyr Pro
340 345 350
Ser Leu Pro Ser Ile Pro Leu Pro Pro Asp Ile Pro Pro Leu Ser Thr
355 360 365
Gln Asn Ile Ser Leu Ile His Val Asp Arg Ile Ile
370 375 380
<210> 247
<211> 414
<212> DNA
<213> African swine fever virus
<400> 247
atgctggtga ttatcctggg aattattggc ctgctggcca gtagcaacct ggtttcatcc 60
tccacttcta ctcgggtagg tggacatctt cctctaacat ttgaaccccc agagaatgaa 120
cttggatact ggtgcactta tgtggaaagc tgtcggttct gctgggattg tgaagatggg 180
atttgtacca gcagggtttg gggaaacaac tccacaagta ttattgagaa tgactatgta 240
aaatattgtg aggtttcccg ctggggtgac ctatgtagat atgatgtgga ggagcacatt 300
taccatagca tgaactgttc tgacccaaag ccctggaatc cttataaaat tgcaaggaag 360
gagtggaaaa agaatgaaca tcccagaaag gatttgaaaa aagatgaatt ctag 414
<210> 248
<211> 414
<212> DNA
<213> African swine fever virus
<400> 248
atgctggtga ttatcctggg aattattggc ctgctggcca gtagcaacct ggtttcatcc 60
tccacttcta ctcgggtagg tggacatctt cctctaacat ttgaaccccc agagaatgaa 120
cttggatact ggtgcactta tgtggaaagc tgtcggttct gctgggattg tgaagatggg 180
atttgtacca gcagggtttg gggaaacaac tccacaagta ttattgagaa tgactatgta 240
aaatattgtg aggtttcccg ctggggtgac ctatgtagat atgatgtgga ggagcacatt 300
taccatagca tgaactgttc tgacccaaag ccctggaatc cttataaaat tgcaaggaag 360
gagtggaaaa agaatgaaca tcccagaaag gatttgaaaa aagatgaatt ctag 414
<210> 249
<211> 414
<212> DNA
<213> African swine fever virus
<400> 249
atgctggtga ttatcctggg agttattggc ctgctggcca gtagcaactt ggtttcatcc 60
tccacttcta ctcggatagg tggacatctt cctctaacat ttgatcctcc agagaatgaa 120
cttggatact ggtgcactta tgtggaaagc tgtcggttct gctgggattg tgaagatggg 180
gtctgtacta gcaggatctg ggggaacaac tccacaagta ttgttgagaa cagctatgta 240
aaatattgtg aagtttcccg ctggggtgac cagtgtagat atgatgtgga ggagcgcatt 300
taccatacca tgaactgttc tgacccaaaa ccctggaatc cttataaaat tacaagggtg 360
gagtggaaaa agaatgaaca tttcagaaag gatttgaaaa aagatgaatt ctag 414
<210> 250
<211> 414
<212> DNA
<213> African swine fever virus
<400> 250
atgctggtga ttatcctggg agttattggc ctgctggcca gtagcaactt ggtttcatcc 60
tccacttcta ctcgggtagg tggacatctt cctctaacat ttgatcctcc agagaatgaa 120
cttggatact ggtgcactta tgtggaaagc tgtcggttct gctgggattg tgaagatggg 180
gtctgtacta gcaggatctg ggggaacaac tccacaagta ttgttgagaa cagctatata 240
aaatattgtg aagtttcccg ctggggtgac cagtgtagat atgatgtgga ggagcacatt 300
tactatacca tgaactgttc tgacccaaag ccctggaatc cttataaaat tgcaaggaag 360
gagtggaaaa agaatgaaca tttcagaaag gatttgaaaa aagatgaatt ctag 414
<210> 251
<211> 378
<212> DNA
<213> African swine fever virus
<400> 251
atgctggtga ttatcctggg agttattggc ctgctggcca gtagcaactt ggtttcatcc 60
tccacttcta ctcgggtagg tggacatctt cctctaacat ttgatcctcc agagaatgaa 120
cttggatact ggtacactta tgtggaaagt tgtcggttct gctgggattg tgaagatggg 180
gtctgtacta gcagggtttg gggaaacaac tccacaagta ttgttgagaa tgactatgta 240
aaatattgtg aggtttctcg ctggggtgac caatgtagat atgatgtgga ggagcacatt 300
tactatacca tgaactgttc tgacccaaag ccctggaatc cttataaaat tgcaaaggaa 360
ggagtggaaa aaggatga 378
<210> 252
<211> 414
<212> DNA
<213> African swine fever virus
<400> 252
atgctggtga ttatcctggg agttattggc ctgctggcca gtagcaactt ggtttcatcc 60
tccacttcta ctcgggtagg tggacatctt cctctaacag aggatcctcc agagaatgaa 120
cttggatact ggtgcactta tgtggaaagc tgtcggttct gctgggattg tgaagatggg 180
atttgtacta gcagggtttg gggaaacaac tccacaagta ttgttgagaa cgactatgta 240
aaatattgtg aggtttctcg ctggggtgac caatgtagat atgatgtaga ggagcacatt 300
tactatacca tgaactgttc tgacccaaag ccctggaatc cttataaaat tgcaaggaag 360
gagtggaaaa aggatgaaca ttccagaaag aatttgaaaa aagatgaatt ctag 414
<210> 253
<211> 414
<212> DNA
<213> African swine fever virus
<400> 253
atgctggtga ttatcctggg aattattggc ctgctggcca gtagcaacct ggtttcatcc 60
tccacttcta ctcgggtagg tggacatctt cctctaacat ttgatccccc agagaatgaa 120
cttggatact ggtgcactta tgtggaaagc tgtcggttct gctgggattg tgaagatggg 180
atttgtacca gcagggtttg gggaaacaac tccacaagta ttgttgagaa tgactatgta 240
aaatattgtg aggtttcccg ctggggaaac ctatgtagat atgatgtgga ggagcacatt 300
tactatagca tgaactgttc tgacccaaag ccctggaatc cttataaaat tgcaaggaag 360
gagtggaaaa agaatgaata tctcagaaag gatttgaaaa aagatgaatt ctag 414
<210> 254
<211> 105
<212> DNA
<213> African swine fever virus
<400> 254
atgaactgtt ctgacccaaa gccctggaat ccttataaaa ttgcaaggaa ggagtggaaa 60
aagaatgaac atcccagaaa ggatttgaaa aaagatgaat tctag 105
<210> 255
<211> 414
<212> DNA
<213> African swine fever virus
<400> 255
atgctggtga ttatcctggg aattattggc ctgctggcca gtagcaacct ggtttcatcc 60
tccacttcta ctcgggtagg tggacatctt cctctaacat ttgatccccc agagaatgaa 120
cttggatact ggtgcactta tgtggaaagc tgtcggttct gctgggattg tgaagatggg 180
atttgtacca gcagggtttg gggaaacaac tccacaagta ttgttgagaa tgactatgta 240
aaatattgtg aggtttcccg ctggggtaac ctatgtagat atgatgtgga ggagcacatt 300
taccatagca tgaactgctc tgacccaaag ccctggaatc cttataaaat tgcaaggaag 360
gagtggaaaa agaatgaaca tcccagaaag gatttgaaaa aagatgaatt ctag 414
<210> 256
<211> 414
<212> DNA
<213> African swine fever virus
<400> 256
atgctggtga ttatcctggg aattattggc ctgctggcca gtagcaacct ggtttcatcc 60
tccacttcta ctcgggtagg tggacatctt cctctaacat ttgatccccc cgagaatgaa 120
cttggatact ggtgcactta tgtggaaagc tgtcggttct gctgggattg tgaagatggg 180
atttgtacca gcagggtttg gggaaacaac tccacaagta ttgttgagaa tgactatgta 240
aaatattgtg aggtttcccg ctggggtaac ctatgtagat atgatgtgga ggagcacatt 300
taccatagca tgaactgctc tgacccaaag ccctggaatc cttataaaat tgcaaggaag 360
gagtggaaaa agaatgaaca tcccagaaag gatttgaaaa aagatgaatt ctag 414
<210> 257
<211> 1587
<212> DNA
<213> African swine fever virus
<400> 257
atgttctccc tacaggacct ctgtcggaag aacactttct tccttccaaa tgattttagc 60
aagcatactc tacaacggct ggggttgtat tggaaagagc atggatccgt ccatcgaata 120
gaaaaggaca gcataatgat acagaatgaa ttggttcttt ctatcaatga tgctttacag 180
cttgcaggag aggaggggga cacagatgtg gtacagctct tgttactatg ggagggaaat 240
ctgcattatg ccatcatagg agctttgaag actgagaatt ataatctagt atgtgagtac 300
catagccaaa ttcaggactg gcatattctc ctacccttga ttcaagatcc agaaacattc 360
gaaaaatgtc atgatttaag ccttggatgt gaccttatat gccttctcca acatgctgta 420
aaatgtgata tgctttctat tcttgttaaa tataaggagg atttactaaa tgtaaggatt 480
aggcatcgta cccaatccct gtttgttttg gcatgcgaaa atcggagatt tgagattatt 540
gaatggatag gtcaaaatct gtcaattcct gaacctgagg ccatttttag cattgctatt 600
gttacaaaag atgtagaact gttttcctta ggatataaaa ttatttttga ttacatgcaa 660
agacaaggaa tttttcaatt aaccaatgta gttcgcatgc ttctgctaaa tcgtcatatt 720
ggtatggcaa tagaaaaagg acttttacct tttattctgg aaactttaaa atatggtggt 780
agtgtaaaaa gagctttatc ttatgcagta atagataata aaagaaaaat tatagactat 840
cttgtacgcc atgaaaatat accccgagga actattgaaa gacttttgca tctagctgtg 900
aaaaaacaat cttccaggaa aactttgaac ttgttgctat cttacataaa ttacaaggtg 960
aaaaatgtta aaaagctggt agagcatgta gtagatcaca aatccactct tgtgttaaaa 1020
attttattgg aaaaaaagga aaatctagtg gatgctgttt taacaagact tgtaaaacat 1080
tctacatatt tccaggtgag agaatttatc caggagtttt ccatcagccc agaaaaattc 1140
attaaaatag ctgtgcggga aaagaaaaat gtgttaatcg aggctatttc tgaagatatt 1200
tgggaaaatc ccacagaaag aattacttat ctcaaacaga tagtgcacac cataaaatat 1260
gaaagtggaa ggcggttttt gatagacatc attcacagca tttaccaaag ttactcacta 1320
aaacacgaag atattcttaa actggcaaca ttttatgtca aacacaatgc aatcacccat 1380
tttaaagatc tctgcaaata tctttggctg aacagaggaa cagaaagtaa gaaactgttt 1440
ttagagtgct tggaaattgc tgatgagaag gagtttcctg atattaaaaa tattgtgagt 1500
gaatatatta actacttgtt tactgcagga gctattacca aggaagaaat catgcaagct 1560
tatgctttag agtatgacat gtattaa 1587
<210> 258
<211> 1587
<212> DNA
<213> African swine fever virus
<400> 258
atgttctccc tacaggacct ctgtcggaag aacactttct tccttccaaa tgattttagc 60
aagcatactc tacaacggct ggggttgtat tggaaagagc atggatccgt ccatcgaata 120
gaaaaggaca gcataatgat acagaatgaa ttggttcttt ctatcaatga tgctttacag 180
cttgcaggag aggaggggga cacagatgtg gtacagctct tgttactatg ggagggaaat 240
ctgcattatg ccatcatagg agctttgaag actgagaatt ataatctagt atgtgagtac 300
catagccaaa ttcaggactg gcatattctc ctacccttga ttcaagatcc agaaacattc 360
gaaaaatgtc atgatttaag ccttggatgt gaccttatat gccttctcca acatgctgta 420
aaatgtgata tgctttctat tcttgttaaa tataaggagg atttactaaa tgtaaggatt 480
aggcatcgta cccaatccct gtttgttttg gcatgcgaaa atcggagatt tgagattatt 540
gaatggatag gtcaaaatct gtcaattcct gaacctgagg ccatttttag cattgctatt 600
gttacaaaag atgtagaact gttttcctta ggatataaaa ttatttttga ttacatgcaa 660
agacaaggaa tttttcaatt aaccaatgta gttcgcatgc ttctgctaaa tcgtcatatt 720
ggtatggcaa tagaaaaagg acttttacct tttattctgg aaactttaaa atatggtggt 780
agtgtaaaaa gagctttatc ttatgcagta atagataata aaagaaaaat tatagactat 840
cttgtacgcc atgaaaatat accccgagga actattgaaa gacttttgca tctagctgtg 900
aaaaaacaat cttccaggaa aactttgaac ttgttgctat cttacataaa ttacaaggtg 960
aaaaatgtta aaaagctggt agagcatgta gtagatcaca aatccactct tgtgttaaaa 1020
attttattgg aaaaaaagga aaatctagtg gatgctgttt taacaagact tgtaaaacat 1080
tctacatatt tccaggtgag agaatttatc caggagtttt ccatcagccc agaaaaattc 1140
attaaaatag ctgtgcggga aaagaaaaat gtgttaatcg aggctatttc tgaagatatt 1200
tgggaaaatc ccacagaaag aattacttat ctcaaacaga tagtgcacac cataaaatat 1260
gaaagtggaa ggcggttttt gatagacatc attcacagca tttaccaaag ttactcacta 1320
aaacacgaag atattcttaa actggcaaca ttttatgtca aacacaatgc aatcacccat 1380
tttaaagatc tctgcaaata tctttggctg aacagaggaa cagaaagtaa gaaactgttt 1440
ttagagtgct tggaaattgc tgatgagaag gagtttcctg atattaaaag tattgtgagt 1500
gaatatatta actacttgtt tactgcagga gctattacca aggaagaaat catgcaagct 1560
tatgctttag agtatgacat gtattaa 1587
<210> 259
<211> 1578
<212> DNA
<213> African swine fever virus
<400> 259
atgttctccc tacaggacct ctgtcggaag aacattttct tccttccaaa tgattttagc 60
aagcataccc tacaatggct gggattatat tggaaagagc atggatccgt ccatcgagca 120
gaaaaagaca gcataatgat acagaatgaa ttggttcttt ctatcaatga tgctttacag 180
cttgcaggag aggaggggga cacagatgta gtacagctct tgttattatg ggagggaaat 240
ctgcattatg ccatcatagg agccttgaag actgaaaaat ataacctaat atgtgagtat 300
catagccaaa ttcaggactg gcatattctc ctacccatga ttcaagatcc agaaacattc 360
gaaaaatgtc atgatttaag ccttggatgt gactttattt gccttctcca acatgctgta 420
aaatacaaca tgctttctat tcttgtcaaa tataaggagg atctactaaa tgcaaggatt 480
aggcatcgta tccaatccct gtttgttttg gcatgcgaaa atcggagaat tgaaattatt 540
gattggatag gccaaaatct gccaattcct gaacctgatg ccatttttag cattgctgtt 600
gctacaagag atttagaact gttttcctta gggtacaaga ttatttttga ttacatgcaa 660
agacagggaa tcattcaatt aaccaatgga gttcgcatgg ttgtgctaaa tcgtcacatt 720
agcatggcaa tagataatgg tcttttacct tttgttctgg aaactttaaa acatggtggg 780
aatatacata gagccttatc ttatgcagta acacacaata gaagaaaaat tctggattat 840
cttattcgcc agaaaaatat agcccctaat acaattgaaa gacttttata tctggccgtg 900
aaaaatcaat cttccaggaa aactttgaac ttgttgctat cttacataaa ttacaaggtg 960
aaaaatgtta aaaagctggt agagcatgta gtaaatgaga aatccactct tgtgttaaaa 1020
attttattag aaaaaaagga aaatctagtg gatgctgttt taacaagact tgtaaaacat 1080
tctacatatt tccaggtgag agaatttatc caggagtttt ccatcagccc agaaaaattc 1140
attaaaatag ctgtgcggga aaagaaaaat gtgttaatcg aggctatttc tgaagatatt 1200
tgggaaaatc ccacagaaag aattacttat ctcaaacaga tagtgcacac cataaaatat 1260
gaaagtggaa ggcgattttt ggtagacatc attcacagca tttaccaaag ttactcacta 1320
aaacacgaag atattcttaa actggcaaca ttttatgtca aacacaatgc aatcacccat 1380
tttaaagacc tctgcaaata tctttggctg aacagaggaa cagaaagtaa gaaactgttt 1440
ttagagtgtt tagaaattgc tgatgagaag gagtttcctg atattaaaag tattgtgagt 1500
gaatatatta actacttgtt tactgcagga gctattacca aggaagaaat catgcaagcc 1560
tatgatgctt tagagtag 1578
<210> 260
<211> 1578
<212> DNA
<213> African swine fever virus
<400> 260
atgttctccc tacaggacct ctgtcggaag aacattttct tccttccaaa tgattttagc 60
aagcataccc tacaatggct gggattatat tggaaagagc atggatccgt ccatcgagca 120
gaaaaagaca gcataatgat acagaatgaa ttggttcttt ctatcaatga tgctttacag 180
cttgcaggag aggaggggga cacagatgta gtacagctct tgttattatg ggagggaaat 240
ctgcattatg ccatcatagg agccttgaag actgaaaaat ataacctaat atgtgagtat 300
catagccaaa ttcaggactg gcatattctc ctacccatga ttcaagatcc agaaacattc 360
gaaaaatgtc atgatttaag ccttggatgt gactttattt gccttctcca acatgctgta 420
aaatacaaca tgctttctat tcttgtcaaa tataaggagg atctactaaa tgcaaggatt 480
aggcatcgta tccaatccct gtttgttttg gcatgcgaaa atcggagaat tgaaattatt 540
gattggatag gccaaaatct gccaattcct gaacctgatg ccatttttag cattgctgtt 600
gctacaagag atttagaact gttttcctta gggtacaaga ttatttttga ttacatgcaa 660
agacagggaa tcattcaatt aaccaatgga gttcgcatgg ttgtgctaaa tcgtcacatt 720
agcatggcaa tagataatgg tcttttacct tttgttctgg aaactttaaa acatggtggg 780
aatatacata gagccttatc ttatgcagta acacacaata gaagaaaaat tctggattat 840
cttattcgcc agaaaaatat agcccctaat acaattgaaa gacttttata tctggccgtg 900
aaaaatcaat cttccaggaa aactttgaac ttgttgctat cttacataaa ttacaaggtg 960
aaaaatgtta aaaagctggt agagcatgta gtaaatgaga aatccactct tgtgttaaaa 1020
attttattag aaaaaaagga aaatctagtg gatgctgttt taacaagact tgtaaaacat 1080
tctacatatt tccaggtgag agaatttatc caggagtttt ccatcagccc agaaaaattc 1140
attaaaatag ctgtgcggga aaagaaaaat gtgttaatcg aggctatttc tgaagatatt 1200
tgggaaaatc ccacagaaag aattacttat ctcaaacaga tagtgcacac cataaaatat 1260
gaaagtggaa ggcgattttt ggtagacatc attcacagca tttaccaaag ttactcacta 1320
aaacacgaag atattcttaa actggcaaca ttttatgtca aacacaatgc aatcacccat 1380
tttaaagacc tctgcaaata tctttggctg aacagaggaa cagaaagtaa gaaactgttt 1440
ttagagtgtt tagaaattgc tgatgagaag gagtttcctg atattaaaag tattgtgagt 1500
gaatatatta actacttgtt tactgcagga gctattacca aggaagaaat catgcaagcc 1560
tatgatgctt tagagtag 1578
<210> 261
<211> 1578
<212> DNA
<213> African swine fever virus
<400> 261
atgttctccc tacaggacct ctgtcggaag aacactttct tccttccaaa tgattttagc 60
aatcataccc tacaacggct ggggttatat tggaaagagc atggatccgt ccatcgaata 120
gaaaaggaca gcataatgat acagaatgaa ttggttcttt ctatcaatga tgctttacat 180
cttgcaggag aggaggggaa cacagatgta gtacagctct tgttattatg ggagggaaat 240
ctgcattatg ccatcatagg agccttgaag actgagaaat ataacctaat atgtgagtac 300
catagccaaa ttcagaactg gcatgttctc ctccccttga ttcaagatcc agaaacattc 360
gaaaaatgtc atgatttaag ccttggatgt gactttattt gccttctcca acatgctgta 420
aaatgtgaca tgctttctat tcttgttaaa tataaggagg atctactaaa tgcaaggatt 480
aggcatcgta tccaatccct gtttgttttg gcatgcgaaa atcggagatt tgagattatt 540
gaatggatag gtcaaaatct gccaattcct gaacctgagg ccatttttag cattgctatt 600
gttacaaaag atatagaact gttttcctta gcgtacaagc ttatttttga ttacatgcaa 660
agacaaggaa cttttcaatt aaccaatatg gtccgcatgc ttctgctaaa tcggtacatt 720
ggtatggcaa tagaaaaagg acttttaccc tttattctgg aaactttaaa atatggtggt 780
agtgtaaata gagctttatc ttatgcagta atagataata aaagaaaaat tatagactat 840
cttgtacgcc atgaaaatat accccgtgga actattgaaa gacttttgca tctagctgtg 900
aaaaaacaat cttccagaaa aactttgaac ttgttgctat cttacataaa ttacaaggtg 960
aaaaatgtta aaaagctggt agagcatgta gtagatcaca actctactct tgtgttaaaa 1020
attttattgg aaaaaaagga aaatctagtg gatgctgttt taacaagact tgtaaaacat 1080
tctacatatt tccgggtaag agaatttatc caggagtttt ccatcagccc agaaaaattc 1140
attaaaatag ctgtgcggga aaagaaaaat gtgttaatcg aggctatttc tgaagatatt 1200
tgggaaaatc ccacagaaag aattacttat ctcaaacaga tagtgcacac cataaaatat 1260
gaaagtggaa ggcggttttt gatagacatc attcacagca tttaccaaag ttattcacta 1320
aaacatgaag atatttttaa actggcaaca ttttatgtca aacacaatgc aatcacccat 1380
tttaaagatc tctgcaaata tctttggctg aacagaggaa cagaaagtaa gaaactgttt 1440
ttagagtgct tggaaattgc tgatgagaag gagtttcctg atattaaaag cattgtgagt 1500
gaatatatta actacttgtt tactgcagga gctattacca aggaagaaat catgcaagcc 1560
tataatgctt tagagtag 1578
<210> 262
<211> 1557
<212> DNA
<213> African swine fever virus
<400> 262
atgttctccc ttcaggacct ctgtcggaag aacattttct tccttccaaa cgattttagc 60
aagcataccc tacaatggct ggggttatat tggaaagagc atggatccgt ccatcgagca 120
gaaaaagaca gcataatgat acagaatgaa ttggttcttt ctatcaatga tgctttactg 180
cttgcaggag aggaggggga cacagatgta gtacagctct tgttgctatg ggaaggaaat 240
ctgcattatg ccatcatagg agccttgaag actgagaaat atagcctagt atgtgagtac 300
catagccaaa ttcaggactg gcatgttctc ctccccttga ttcaagatcc agaaacattc 360
gaaaaatgtc atgatttaag ccttgaatgt gactttatat gccttctaca acatgctgta 420
aaatgtgaca tgctttctat tcttgttaaa tataaagagg atctactaaa tgtaaggatt 480
aggcatcgta tccaatccct gtttgttttg gcatgcgaaa atcggagatt tgagattatt 540
gaatggatag gtcaaaatct gccaattcct gaacctgagg ccatttttag cattgctatt 600
gttacaaaag atatagaact gttttcctta ggatacaagc ttatttttga ttacatgcaa 660
agacaaggaa cttttcaatt aaccaatatg gttcgcatgc ttctgctaaa tcgttacatt 720
ggtatggcaa tagaaaaagg ccttttaccc tttatcgtgg aaactttaaa atatggtggt 780
agtgtaaata gagctttatc ttatgcagtc atagataata aaagaaaaat tatagactat 840
cttgtacgtc atgaaaatat accccgtgga actattgaaa gacttttgca tctagctgtg 900
aaaaaacaat cttccagaaa aactttgaac ttgttgctat cttacataaa ctacaaggtg 960
aaaaatgtta aaaagctggt agagcatgta gtagatcaca actctaccct tgtgttaaaa 1020
attttattgg aaaaaaagga aaatttagtg gatgctgttt taacaagact tgtaaaacat 1080
tctacatatt tccgggtgag agaatttatc caggagtttt ccatcagccc agaaaaattc 1140
attaaaatag ctgtgcggga acagaaaaat gtgttaatcg aggctatttc tgaagatatt 1200
tgggaaaatc ccacagaaag aattacttat ctcaaacaga tagtgcacac cataaaatat 1260
gaaagtggaa ggcggttttt gatagacatc attcacagca tttaccaaag ttactcacta 1320
aaacacgaag atattcttaa actggcaata ttttatgtca aatacaatgc aatcacccat 1380
tttaaagatc tctgcaaata tctttggctg aacagaggaa cagaaagtaa gaaactgttt 1440
ttagagtgct tggaaattgc tgatgagaag gagtttcctg atattaaaag cattgtgagt 1500
gaatatatta actacttgtt tactgcagga gctattacta aggaagaaat catataa 1557
<210> 263
<211> 1581
<212> DNA
<213> African swine fever virus
<400> 263
atgttctccc ttcaggacct ctgtcggaag aacactttct tccttccaaa tgattttagc 60
aagcataccc tacaacggct ggggttatat tggaaagagc atggatccgt ccatcgagca 120
gaaaaagaca gcataatgat acagaatgaa ttggttcttt ctatcaatga tgctttacag 180
cttgcaggag aggaggggga cacagatgta gtacagctct tattattatg ggaaggaaat 240
cttcattatg ccatcatagg agccttgaag actgagaaat ataacctaat atatgagtac 300
catagccaaa ttcaggactg gcatgttctc ttacccatga ttcaagatcc agaaacattc 360
gaaaaatgtc atgatttaag ccttgcatgt gactttatat gccttctcca acatgctata 420
aaatataaca tgctttctat ccttgtcaaa tataaggaag acttactaaa tgtaaggatt 480
aggtatcgta tccaatccct gtttgttttg gcatgtgaaa accggagaat tgagattatt 540
gaatggatag gtcaaaatct gccaattcct gaacctgatg ccatttttag cattgctgtt 600
gctacaagag atttagaact gttttcctta gggtacaaga ttatttttga ttacatgcaa 660
agacagggaa tctttcaatt aaccaatgga gttcgcatgg ttgtgctaaa tcgtcacatt 720
agcatggcaa tagataatgg tcttttaccc tttgttctgg aaactttaaa acatggtggg 780
aatatacata gagccttatc ttatgcagta acacacaata aaagaaaaat tctggattat 840
cttattcgcc agaaaaatat agcccctaat acaattgaaa gacttttata tctggccgtg 900
aaaaatcaat catccagaaa aactttgaac ttgttactat cttacataaa ttacaaggtg 960
aaaaatgtta aaaagctggt agagcatgta gtaaatgaga aatccactct tgtgttaaaa 1020
attttattag aaaaaaagga aaatctagtg gatgctgttt taacaagact tgtaaaacat 1080
tctacatatt tccaggtgag agaatttatc caggagtttt ccatcagccc agaaaaattc 1140
attaaaatag ctgtgcggga aaagaaaaat gtgttgatcg aggctatttc tgaagatatt 1200
tgggaaaatc ccacagaaag aattacttat ctcaaacaga tagtgcacac cataaaatat 1260
gaaagtggaa ggcgattttt ggtagacatc attcacagca tttaccaaag ttactcacta 1320
aaacacgaag atattcttaa actggcaaca ttttatgtca aacacaatgc aaccacccat 1380
tttaaagatc tctgcaaata tctttggctg aacagaggaa cagaaagtaa aaaactcttt 1440
ttagagtgtt tagaaattgc tgatgagaag gagtttcctg atattaaaag cattgtgagt 1500
gaatatatta actacttgtt tactgcagga gctattacca aggaagaagc ctatggatgc 1560
tttagagtag ccatgtatta a 1581
<210> 264
<211> 1578
<212> DNA
<213> African swine fever virus
<400> 264
atgttctccc tacaggacct ctgtcggaag aacattttct tccttccaaa cgattttagc 60
aagcataccc tacaatggct ggggttatat tggaaagagc atggatccgt ccatcgagca 120
gaaaaagaca gcataatgat acagaatgaa ttggttcttt ctatcaatga tgctttactg 180
cttgcaggag aggaggggga catagatgta gtacagctct tgttattatg ggagggtaat 240
ctgcattatg ccatcatagg agccttgaag actgagaaat ataacctaat atgtgagtac 300
catagccaaa ttcaggactg gcatattctc ctacccatga ttcaagatcc agaaacattc 360
gaaaaatgtc atgatttaag ccttgcatgt gactttatat gccttctcca acatgctgta 420
aaatataaca tgctttctat ccttgtcaaa tataaggaag acttactaaa tgtaaggatt 480
aggtatcgta tccaatccct gtttgttttg gcatgcgaaa accggagaat tgagattatt 540
cattggatag gccaaaatct gccaattcct gaacctgatg ccatttttag cattgctgtt 600
gctacaagag atttagaact gttttcctta gggtacaaga ttatttttga ttacatgcaa 660
agacagggaa tctttcaatt atccaatgga gttcgcatgg ttgtgctaaa tcgtcacatt 720
agcatggcaa tagataatgg acttttaccc tttgttctgg aaactttaaa acatggtggg 780
aatatacata gagccttatc ttatgcagta acacacaata gaagaaaaat tctggattat 840
cttattcgcc agaaaaatat agcccctaat acaattgaaa gacttttata tctggccgtg 900
aaaaatcaat cttccaggaa aactttgaac ttgttgctat cttacataaa ttacaaggtg 960
aaaaatgtta aaaagctggt agagcatgta gtaaatgaga aatccactct tgtgttaaaa 1020
attttattgg aaaaaaagga aaatctagtg gatgctgttt taacaagact tgtaaaacat 1080
tctacatatt tccaggtgag agaatttatc caggagtttt ccatcagccc agaaaaattc 1140
attaaaatag ctgtgcggga aaagaaaaat gtgttaatcg aggctatttc tgaagatatt 1200
tgggaaaatc ccacagaaag aattacttat ctcaaacaga tagtgcacac cataaaatat 1260
gaaagtggaa gacgattttt gatagagatc attcacagca tttaccaaag ttactcacta 1320
aaacacgaag atattcttaa actggcaaca ttttatgtca aacacaatgc aaccacccat 1380
tttaaagatc tctgcaaata tctttggctg aacagaggaa cagaaagtaa gaaactgttt 1440
ttagagtgtt tagaaattgc tgatgagaag gagtttcctg atattaaaag tattgtgagt 1500
gaatatatta actacttgtt tactgcagga actattacca aggaagaaat catgcaagcc 1560
tatgatgctt tagagtag 1578
<210> 265
<211> 1578
<212> DNA
<213> African swine fever virus
<400> 265
atgttctccc ttcaggacct ctgtcggaag aacattttct tccttccaaa tgattttagc 60
aagcataccc tacaatggct ggggttatat tggaaagagc atggatccgt ccatcgagca 120
gaaaaaaaca gcatagtgat acagaatgaa ttggttcttt ctatcaatga tgctttacag 180
cttgcagggg aagaggggga cacagatgta gtacagctct tgttattatg ggagggaaat 240
ctgcattatg ccatcatagg agccttgaag actgagaaat ataatctaat atgtgagtac 300
catagccaaa ttcaggactg gcatgttctc ctccccttga ttcaagatcc agaaacattc 360
gaaaaatgtc atgatttaag ccttgcatgt gactttatat gccttctaca acatgctgta 420
aaatataaca tgctttctat ccttgtcaaa tataaggaag acttactaaa tgtaaggatt 480
aggtatcgta tccaatccct gtttgttttg gcatgtgaaa accggagaat tgagattatt 540
gattggatag gccaaaatct gccaattcct gaacctgatg ccatttttag cattgctgtt 600
gctacaagag atttagaact gttttcctta gggtacaaga ttatttttga ttacatgcaa 660
agacagggaa tctttcaatt atccaatgga gttcgcatgg ttgtgctaaa tcgtcacatt 720
agcatggcaa tagataatgg acttttaccc tttgttctgg aaactttaaa acatggtggg 780
aatatacata gagccttatc ttatgcagta acacacaata gaagaaaaat tctggattat 840
cttattcgcc agaaaaatat agcccctaat acaattgaaa gacttttata tctggccgtg 900
aaaaatcaat cttccaggaa aactttgaac ttgttgctat cttacataaa ttacaaggtg 960
aaaaatgtta aaaagctagt agagcatgta gtaaatgaga aatccactct tgtgttaaaa 1020
attttattgg aaaaaaagga aaatctagtg gatgctgttt taacaagact tgtaaaacat 1080
tctacatatt tccaggtgag agaatttatc caggagtttt ccatcagccc agaaaaattc 1140
attaaaatag ctgtgcggga aaagaaaaat gtgttaatcg aggctatttc tgaagatatt 1200
tgggaaaatc ccacagaaag aattacttat ctcaaacaga tagtgcacac cataaaatat 1260
gaaagtggaa gacgattttt gatagacatc attcacagca tttaccaaag ttactcacta 1320
aaacacgaag atattcttaa actggcaaca ttttatgtca aatacaatgc aatcacccat 1380
tttaaagatc tctgcaaata tctttggctg aacagaggaa cagaaagtaa gaaactgttt 1440
ttagagtgtt tagaaattgc tgatgagaag gagtttcctg atattaaaag cattgtgagt 1500
gaatatatta actacttgtt tactgcagga gctattacca aggaagaaat catgcaagcc 1560
tatgatgctt tagagtag 1578
<210> 266
<211> 618
<212> DNA
<213> African swine fever virus
<400> 266
atgttggtga tcttcttggg aattcttggc cttctggcca gccaggtttc aagtcagctc 60
gttggacaac ttcgtccaac agaggagcct ccagaggaag aactcgaata ctggtgtgcc 120
tacatggaaa gttgccaatt ttgctgggac tgccaagacg gcacttgtat aaacaaaata 180
gatgggtcag taatttacaa gaatgagtat gtgaaatcat gtctggtttc ccgttggctg 240
gataaatgta tgtatgattt agataagggt atctaccata ccatgaattg caaccaggtc 300
ttagggctac ctaatcaacc agctggacaa cttcatccaa cggataatcc tccacaagaa 360
gaacttgaat actggtgcac ttatacagaa aactgcaagt tttgctggaa ttgtcaaaat 420
ggcctttgtg agggcaaatt ggagaataca acaattcttg aaaatgagta tgtgcaatca 480
tgtatagttt cccgctggct aaataaatgt atgtatgatc taggacaggg gattcaccat 540
gtaatggcct gttctgaacc aaagccctgg aatccttaca aaatcttaaa gagagagtgg 600
aaagaaaata atagttaa 618
<210> 267
<211> 618
<212> DNA
<213> African swine fever virus
<400> 267
atgttggtga tcttcttggg aattcttggc cttctggcca gccaggtttc aagtcagctc 60
gttggacaac ttcgtccaac agaggagcct ccagaggaag aactcgaata ctggtgtgcc 120
tacatggaaa gttgccaatt ttgctgggac tgccaagacg gcacttgtat aaacaaaata 180
gatgggtcag taatttacaa gaatgagtat gtgaaatcat gtctggtttc ccgttggctg 240
gataaatgta tgtatgattt agataagggt atctaccata ccatgaattg caaccaggtc 300
ttagggctac ctaatcaacc agctggacaa cttcatccaa cggataatcc tccacaagaa 360
gaacttgaat actggtgcac ttatacagaa aactgcaagt tttgctggaa ttgtcaaaat 420
ggcctttgtg agggcaaatt ggagaataca acaattcttg aaaatgagta tgtgcaatca 480
tgtatagttt cccgctggct aaataaatgt atgtatgatc taggacaggg gattcaccat 540
gtaatggcct gttctgaacc aaagccctgg aatccttaca aaatcttaaa gagagagtgg 600
aaagaaaata atagttaa 618
<210> 268
<211> 372
<212> DNA
<213> African swine fever virus
<400> 268
atgttggtga tcttcttggg actccttggc ctgctggcca accaggtctt agggctacct 60
aatcaaccag ctggacaact tcatccaacg gataatcctc caaaagaaga acttggatac 120
tggtgcactt acacggaaag ctgtaaattt tgctggaact gtcaaaatgg cctttgtgag 180
ggcaaattgg agaatacaac aattcttgaa aatgagtatg tgcaatcatg tatagtttcc 240
cgctggctaa ataaatgtat gtatgatcta ggacagggga ttgaccatgt aatggcctgt 300
tctgaaccaa agccctggaa tccttacaaa atcttaaaga gagagtggaa aaaaaatgtc 360
agccaaaatt aa 372
<210> 269
<211> 372
<212> DNA
<213> African swine fever virus
<400> 269
atgttggtga tcttcttggg actccttggc ctgctggcca accaggtctt agggctacct 60
aatcaaccag ctggacaact tcatccaacg gataatcctc caaaagaaga acttggatac 120
tggtgcactt acacggaaag ctgtaaattt tgctggaact gtcaaaatgg cctttgtgag 180
ggcaaattgg agaatacaac aattcttgaa aatgagtatg tgcaatcatg tatagtttcc 240
cgctggctaa ataaatgtat gtatgatcta ggacagggga ttcaccatgt aatgccctgt 300
tctgaaccaa agccctggaa tccttacaaa atcttaaaga aagagtggaa agaaaatgtc 360
agccaaaatt aa 372
<210> 270
<211> 363
<212> DNA
<213> African swine fever virus
<400> 270
atgttggtta tcttcttggg aattcttggc cttctggcca accaggtctc aagccagctc 60
gttggacaac ttcatccaac ggaaaatcct tcagagaatg aacttgaata ctggtgcact 120
tacatggaat gttgccagtt ttgctgggac tgtcaagatg gcctttgtgt gaataagttg 180
ggaaatacaa caattcttga aaatgagtat gtgcatccat gtatagtttc ccgctggcta 240
aataaatgta tgtatgatct gggtcaaggc attgatcatg taatggtctg ttctcaacca 300
aagtactgga atccttataa aatcttaaag aaagagtgga aagaaaataa cagccaaaat 360
taa 363
<210> 271
<211> 363
<212> DNA
<213> African swine fever virus
<400> 271
atgttagtaa tcttcttggg aattcttggc cttctggcca accaggtctc aagccagctc 60
gttggacaac ttcatccaac ggaaaatcct tcagagaatg aacttgaata ctggtgcact 120
tacatggaat gttgccagtt ttgctgggac tgtcaagatg gcctttgtgt gaataagttg 180
ggaaatacaa caattcttga aaatgagtat gtgcatccat gtatagtttc ccgctggcta 240
aataaatgca tgtatgatct gggtcaaggc attgatcatg taatggtctg ttctcaacca 300
aagtactgga atccttataa aatcttaaag aaagagtgga aagaaaataa cagtcaaaat 360
taa 363
<210> 272
<211> 366
<212> DNA
<213> African swine fever virus
<400> 272
atgttagtaa tcttcttggg aattcttggc cttctggcca accaggtctc aagccagctc 60
gttggacaac ttcatccaac ggaaaatcct tcagagaatg aacttgaata ctggtgcact 120
tacatggaat gttgccagtt ttgctgggac tgtcaaaatg gcctttgtgt gaataagttg 180
ggaaatacaa caattcttga aaatgagtat gtgcatccat gtatagtttc ccgctggcta 240
aataaatgta tgtatgatct gggtcaaggc attgatcatg taatggtctg ttctcagcca 300
aaatactgga atccttataa aatcttaaag aaagagtgga aagaaaataa cagccaaaat 360
aaataa 366
<210> 273
<211> 357
<212> DNA
<213> African swine fever virus
<400> 273
atgttagtca tcttcttggg aattcttggc cttctggtca accaggtctc aagccagcca 60
gttggacaac ttcatccaac ggaaaatcct tcagagaatg aacttgaata ctggtgcact 120
tacatggaat gttgccagtt ttgctgggac tgtcaaaatg gcctttgtgt gaataagttg 180
ggaaatacaa caattcttga aaatgagtat gtgcatccat gtatagtttc ccgctggcta 240
aataaatgta tgtatgatct gggtcaaggc attgatcatg taatggtctg ttctcaacca 300
aaatactgga atccttataa aatcttaaag aaagagtgga aagaaaataa tagttaa 357
<210> 274
<211> 366
<212> DNA
<213> African swine fever virus
<400> 274
atgttagtaa tctttttggg aattcttggc cttctggcca accaggtctc aagccagctc 60
gttggacaac ttcatccaac ggaaaatcct tcagagaatg aacttgaata ctggtgcact 120
tacatggaat gttgccagtt ttgctgggac tgtcaaaatg gcctttgtgt gaataagttg 180
ggaaatacaa caattcttga aaatgagtat gtgcatccat gtatagtttc ccgctggcta 240
aataaatgta tgtacgatct gggtcaaggc attgatcatg taatggtctg ttctcaacca 300
aaatactgga atccttataa aatcttaaag aaagagtgga aagaaaataa cagccaaaat 360
aaataa 366
<210> 275
<211> 366
<212> DNA
<213> African swine fever virus
<400> 275
atgttagtaa tcttcttggg aattcttggc cttctggcca accaggtctc aagccagctc 60
gttggacaac ttcatccaac ggaaaatcct tcagagaatg aacttgaata ctggtgcact 120
tacatggaat gttgccagtt ttgctgggac tgtcaaaatg gcctttgtgt gaataagttg 180
ggaaatacaa caattcttga aaatgagtat gtgcatccat gtatagtttc ccgctggcta 240
aataaatgta tgtacgatct gggtcaaggc attgatcatg taatggtctg ttctcaacca 300
aaatactgga atccttataa aatcttaaag aaagagtgga aagaaaataa cagccaaaat 360
aaataa 366
<210> 276
<211> 312
<212> DNA
<213> African swine fever virus
<400> 276
atgaaggttt ttctaggact tttactaggt tattcaacca tcctcattct tacatatcaa 60
tcaccaacaa cccagtggtg tttttatgaa atatcactta aaatacttaa tcatcatagc 120
atggaaaaat ggagggataa gaattggtca atcattataa ggtattattg tttttacctt 180
gtatttagct ttgcatttgc tggttgcgtt gcatttgcga tctgcaaaaa tctacgactg 240
tgtacaacca tgaaattact tatgcttttg aatattttgg ttttgttatc tcagccaatt 300
ttgaataatt ga 312
<210> 277
<211> 360
<212> DNA
<213> African swine fever virus
<400> 277
atgaaggttt ttctaggact tttactaggt tattcaacca tccttattct tacctatcaa 60
tcaccaacaa ccccgtggtg tttttatgaa atatcactta aaatacctaa tcatcatagc 120
atgaaatgtt gttcgtatcc tagactttat gaacatgaaa tgttcatgga aaaatggagg 180
gataagaatt ggccaatcat tataaggtat tattgttttt accttgtatt tagctttgta 240
tttgctggtt gcgttgcatt tgcgatctgc aaaaatctac gactgagtac aaccatgaaa 300
ttacttatgc ttttgagtat tttggttttg ttgttatctc agccaatctt gaataattga 360
<210> 278
<211> 360
<212> DNA
<213> African swine fever virus
<400> 278
atgaaggttt ttctaggact tttactaggt tattcaacca tccttattct tacctatcaa 60
tcaccaacaa ccccgtggtg tttttatgaa atatcactta aaatacctaa tcatcatagc 120
atgaaatgtt gttcgtatcc tagactttat gaacatgaaa tgttcatgga aaaatggagg 180
gataagaatt ggccaatcat tataaggtat tattgttttt accttgtatt tagctttgta 240
tttgctggtt gcgttgcatt tgcgatctgc aaaaatctac gactgagtac aaccatgaaa 300
ttacttatgc ttttgagtat tttggttttg ttgttatctc agccaatctt gaataattga 360
<210> 279
<211> 507
<212> DNA
<213> African swine fever virus
<400> 279
atgaaggttt ttctaggact tttactaggt ttttcaatca tcctcattct tacatatcaa 60
tcaccgacaa ctcagcatcc tcctaaggaa gagcttgcgt actggtgcac ttatgcaaaa 120
tcttgtgact tctgctggga ttgccaaaat gacacttgta taaataaggt aataaatgag 180
tctatttcga taacttcgat tgtaaactgt agagttactc gcgattccca atcctgtttt 240
tatgaaatat cagttaaaat acctaatcat catagcatgg aatgttcata tcctagactt 300
tatgaacatg aaatgtttat ggaaaaatgg agggatgagt attggccaat cattataaaa 360
cagtgttgtt tttaccttgt atttagcatt gcatttgctg gatgcgttgc atttgcgatc 420
tgcaaaaatc tacgactgcg tacaactata aaactactta ttcttttgag tattttggtt 480
tggttgtctc aaccagtctt gaattga 507
<210> 280
<211> 516
<212> DNA
<213> African swine fever virus
<400> 280
atgaaggttt ttctggcact tttactaggt tatttaacta tcctcattct tacatatcaa 60
acaccaacaa cccagcatcc tcctaaggag gagcttccat attggtgtac gtatgtaaag 120
aattgcgacc tctgttggga ttgtcaagat agcatctatt ggaacaaggt aataagtgag 180
tctatttcga taaattcgat tataaactgt agagttactt gcgattccca atctcagtcc 240
tgcttttatg aaatattact taaaatacct aatcatcata gcatggaatg ttcttatcct 300
ggatcgtatg aaaatgaaat gttcatggaa aaatggaggg atgagaattg gtcaatcatt 360
ataaaacatt attgttttta ccttgtattt agctttgcat ttgctggttg cgttgcattt 420
gcgatctgca aaaatctacg actgagtaca actatgaaat tacttatgct tttgagtatt 480
ttggtttgct tatctcagcc aatcttgaat aattga 516
<210> 281
<211> 510
<212> DNA
<213> African swine fever virus
<400> 281
atgaaggttt ttctaggact tttactaggt ttttcaatca tcctcattct tacatatcaa 60
tcaccgacaa cccagcatcc tcctaaggaa gagcttgcgt actggtgcac ttatgcaaaa 120
tcttgtgact tctgctggga ttgccaaaat gacacttgta taaataaggt aataaatgag 180
tctatttcga taacttcgat tgtaaactgt agagttactc gcgattccca gtcctgtttt 240
tatgatatat cagttaaaat acctaatcat catagcatgg aatgttcata tcctagactt 300
tatgaacatg aaatgtttat ggaaaaatgg agggatgagt attggccaat cattataaaa 360
cagtgttgtt tttaccttgt atttagcttt gcatttgctg gttgcgttgc atttgcgatc 420
tgcaaaaacc tacgactgcg tacaactata aaactactta ttcttttgag tattttggtt 480
tggttatctc agccaatctt gaataattga 510
<210> 282
<211> 312
<212> DNA
<213> African swine fever virus
<400> 282
atgaaggttt ttctaggact tttactaggt tattcaacca tcctcattct tacatatcaa 60
tcaccaacaa cccagtggtg tttttatgaa atatcactta aaatacttaa tcatcatagc 120
atggaaaaat ggagggataa gaattggtca atcattataa ggtattattg tttttacctt 180
gtatttagct ttgcatttgc tggttgcgtt gcatttgcga tctgcaaaaa tctacgactg 240
tgtacaacca tgaaattact tatgcttttg aatattttgg ttttgttatc tcagccaatt 300
ttgaataatt ga 312
<210> 283
<211> 516
<212> DNA
<213> African swine fever virus
<400> 283
atgaaggttt ttctaggact tttactaggt tattcaacca tcctcattct tacatatcaa 60
tcaccaacaa cccagcatcc tcctaaggaa gagcttgagt attggtgcac ttatgcaaaa 120
acttgtgact tctgctggga ttgccaaaat gacacttgta taaataaggt aataaatgaa 180
tctatttcga tgaattcgat tgtaaactgt agagttactc gcgattccca atcccagtcc 240
tgtttttatg aaatatcact taaaatacct aattatcata gcatggaatg ttcatatcct 300
agactttata aacatttcat gtccatggaa aaatggaggg atgagaattg gccaatcctt 360
ataagacatt attgttttta ccttgtattt agctttgcat ttgctggttg cgttgcattt 420
gcgatctgca aaaatctacg actgcgtaca accatgaaat tacttatgct tttgagtatt 480
ttggttttgt tatctcagcc aatcttgaat aattga 516
<210> 284
<211> 324
<212> DNA
<213> African swine fever virus
<400> 284
atgaacgcaa ccatgaaggt ttttctagga cttttactag gttattcaac catcctcatt 60
cttacatatc aatcaccgac aacccagtgg tgtttttatg aaatatcact taaaatactt 120
aatcatcata gcatggaaaa atggagggat aagaattggt caatcattat aaggtattat 180
tgtttttacc ttgtgtttag ctttgcattt gccggttgcg ttgcatttgc gatctgcaaa 240
aatctacgac tgtgtacaac catgaaatta cttatgcttt tgggtatttt ggttttgtta 300
tctcagccaa tcttgaataa ttga 324
<210> 285
<211> 354
<212> DNA
<213> African swine fever virus
<400> 285
atgaaggttt ttctaggact tttactaggt tattcaacca tcctcattct tacatatcaa 60
tcaccagcaa cccagtggtg tttttatgaa atatcactta aaatacctaa tcatcatagc 120
atggaatgtt catatcctag actttataaa catttcatat tcatggaaaa atggagggat 180
aagaattggt caatcattat aaggtattat tgtttttacc ttgtatttag ttttgcattt 240
gctggttgca ttgcatttgc gatctgcaaa aatctacgac tgtgtacaac tatgaaatta 300
cttatgcttt tgagtatttt ggttttgtta tctcagccaa tcttgaataa ttga 354
<210> 286
<211> 354
<212> DNA
<213> African swine fever virus
<400> 286
atgaaggttt ttctaggact tttactaggt tattcaacca tcctcattct tacatatcaa 60
tcaccagcaa cccagtggtg tttttatgaa atatcactta aaatacctaa tcatcatagc 120
atggaatgct catatcctag actttataaa catttcatgt tcatgaaaaa atggagggat 180
aagaattggt caatcattat aaggtattat tgtttttacc ttgtatttag ttttgcattt 240
gctggttgca ttgcatttgc gatctgcaaa aatctacgac tgtgtacaac tatgaaatta 300
cttatgcttt tgagtatttt ggttttgtta tctcagccaa tcttgaataa ttga 354
<210> 287
<211> 714
<212> DNA
<213> African swine fever virus
<400> 287
atgttagaaa tagtattggc aacgctgcta ggcgacctgc agcggctccg ggttcttacc 60
cctcagcagc gggcagttgc cttctttcga gccaatacta aggagctaga ggacttctta 120
tgctcagatg ggcagtctga ggaggtactg tctggccccc ttcttaaccg tctactagaa 180
ccctcaggcc ctcttgatat tttaaccgga tatcacctat ttcgtcagaa tcccaaggca 240
ggtcagttgc gcggccttga ggtcaagatg cttgaacggt tatacgatgc taatatttac 300
aatatactgt ctcggctgcg gcctgaaaaa gttcgcaaca aggctattga gctatactgg 360
gttttccgag ctatccatat ttgtcatgct cctttagttt tagatattgt acgatatgag 420
gaaccggact ttgctgaact ggcctttatt tgtgctgctt actttggtga acctcaggta 480
atgtatttgc tctacaaata tatgcctctg acccgcgcag ttcttacgga tgccatccgg 540
ataagtcttg agagcaacaa ccaggtaggg atttgctatg cttacttgat gggaggcagc 600
ctcaagggac tagtctccgc cccactgcgt aaacgtctgc gcgccaaact acgctcgcag 660
cgcaaaaaga aggacgttct ttcaccccac gacttcttac tgctgctcca gtag 714
<210> 288
<211> 714
<212> DNA
<213> African swine fever virus
<400> 288
atgttagaaa tagtattggc aacgctgcta ggcgacctgc agcggctccg ggttcttacc 60
cctcagcagc gggcagttgc cttctttcga gccaatacta aggagctaga ggacttctta 120
tgctcagatg ggcagtctga ggaggtactg tctggccccc ttcttaaccg tctactagaa 180
ccctcaggcc ctcttgatat tttaaccgga tatcacctat ttcgtcagaa tcccaaggca 240
ggtcagttgc gcggccttga ggtcaagatg cttgaacggt tatacgatgc taatatttac 300
aatatactgt ctcggctgcg gcctgaaaaa gttcgcaaca aggctattga gctatactgg 360
gttttccgag ctatccatat ttgtcatgct cctttagttt tagatattgt acgatatgag 420
gaaccggact ttgctgaact ggcctttatt tgtgctgctt actttggtga acctcaggta 480
atgtatttgc tctacaaata tatgcctctg acccgcgcag ttcttacgga tgccatccgg 540
ataagtcttg agagcaacaa ccaggtaggg atttgctatg cttacttgat gggaggcagc 600
ctcaagggac tagtctccgc cccactgcgt aaacgtctgc gcgccaaact acgctcgcag 660
cgcaaaaaga aggacgttct ttcaccccac gacttcttac tgctgctcca gtag 714
<210> 289
<211> 219
<212> DNA
<213> African swine fever virus
<400> 289
atgcaaaata aaatcccaaa ttttaacctt ttcttttttt ttctatacag gatgttagaa 60
atagtattgg caacgctgct aggcgacctg cagcggctcc gggttcttac ccctcagcag 120
cgggcggttg ccttctttcg agccaatact aaggagctag aggacttctt acgctcagat 180
gggcaatctg aggagatact gtctggcccc cctccttaa 219
<210> 290
<211> 765
<212> DNA
<213> African swine fever virus
<400> 290
atgcaaaata aaatcccaaa ttttaacctt ttcttttttt ttctatacag gatgttagaa 60
atagtattgg caacgctgct aggcgacctg cagcggctcc gggttcttac ccctcagcag 120
cgggcggttg ccttctttcg agccaatact aaggagctag aggacttctt acgctcagat 180
gggcaatctg aggagatact gtctggcccc ctccttaacc gtctactaga accctcatgc 240
cctcttgata ttttaaccgg atatcaccta tttcgtcaga atcccaaggc aggtcagttg 300
cgcggccttg aggtcaagat gcttgaacgg ttatacgatg ctaatattta caatatattg 360
tctcggctgc gacctgaaaa agtccgcaac aaggctattg agctatactg ggttttccga 420
gctatccata tttgtcatgc tcctttagtt ttagatattg tacgatatga ggaaccggac 480
tttgctgaac tggcctttat ttgtgctgct tactttggtg aacctcaggt aatgtatttg 540
ctctacaaat atatgcctct gacccgcgca gttcttacgg atgccatcca gataagtctt 600
gagagcaaca accaggtagg gatttgctat gcttacttga tgggaggcag cctcaaggga 660
ctagtctccg ccccactgcg taaacgtctg cgcgccaaac tacgctcgca gcgcaaaaag 720
aaggacgttc tttcacccca cgacttctta ctgctgctcc agtag 765
<210> 291
<211> 765
<212> DNA
<213> African swine fever virus
<400> 291
atgcaaaata aaatcccaaa ttttaacctt ttcttttttt ttctatacag gatgttagaa 60
atagtattgg caacgctgct aggcgacctg cagcggctcc gggttcttac ccctcagcag 120
cgggcggttg ccttctttcg agccaatact aaggagctag aggacttctt acgctcagat 180
gggcaatctg aggagatact gtctggcccc ctccttaacc gtctactaga accctcatgc 240
cctcttgata ttttaaccgg atatcaccta tttcgtcaga atcccaaggc aggtcagttg 300
cgcggccttg aggtcaagat gcttgaacgg ttatacgatg ctaatattta caatatattg 360
tctcggctgc gacctaaaaa agtccgcaac aaggctattg agctatactg ggttttccga 420
gctatccata tttgtcatgc tcctttagtt ttagatattg tacgatatga ggaaccggac 480
tttgctgaac tggcctttat ttgtgctgct tactttggtg aacctcaggt aatgtatttg 540
ctctacaaat atatgcctct gacccgcgca gttcttacgg atgccatcca gataagtctt 600
gagagcaaca accaggtagg gatttgctat gcttacttga tgggaggcag cctcaaggga 660
ctagtctccg ccccactgcg taaacgtctg cgcgccaaac tacgctcgca gcgcaaaaag 720
aaggacgttc tttcacccca cgacttctta ctgctgctcc agtag 765
<210> 292
<211> 714
<212> DNA
<213> African swine fever virus
<400> 292
atgttagaaa tagtattggc aacgctgcta ggtgacctgc agcggctccg ggttcttacc 60
cctcagcagc gggcggttgc cttctttcga gccaatacta aggagctaga ggacttttta 120
tgctcagatg ggcagtctga ggagatactg tccggccccc tccttaaccg tctactagaa 180
ccctcaggcc ctcttgatat tttaaccgga tatcacttat ttcgtcagaa tcccaaggca 240
ggtcaggtgc gcggccttga ggtcaagatg cttgaacggt tatacgatgc taatatttac 300
aatatattgt ctcggctgcg acctgaaaaa gttcgcaaca aggctgttga gctatactgg 360
gtttttcggg ctatcaatat gtgtcatgct cctttagttt tagatattgt acgatatgag 420
gaaccggact ttgctgaact ggcctttatt tgtgctgctt actttggtga acctcaggta 480
atgtatttgc tctacaaata tatgcctctg acccgcgcag ttcttacgga tgccatccag 540
ataagtcttg agagcaacag ccaggtaggg atttgctatg cctacttgat gggaggcagc 600
ctcaagggcc tagtccgtgc cccactacgt aaacgtctgc gcgccaaact acgctcgcag 660
cgcaaaaaga aggacgttct tccaccccat gacttcttac tgctgctcca gtaa 714
<210> 293
<211> 714
<212> DNA
<213> African swine fever virus
<400> 293
atgttagaaa tagtattggc aacgctgcta ggtgacctgc agcggctccg ggttcttacc 60
cctcagcagc gggcggttgc cttctttcga gccaatacta aggaggtaga agacttctta 120
tgctcagatg ggcagtctga ggaggtactg tccggccccc tccttaaccg tctactagaa 180
ccctcaggcc ctcttgatat tttaaccgga tatcacttat ttcgtcagaa tcccaaggcg 240
ggtcaggtgc gcggccttga ggtcaagatg cttgaacggt tatacgatgc taatatttac 300
aatatattgt ctcggctgcg acctgaaaaa gttcgcaaca aggctgttga gctatactgg 360
gtttttcggg ctatcaatat gtgtcatgct cctttagttt tagatattgt acgatatgag 420
gaaccggact ttgctgaact ggcctttatt tgtgctgctt actttggtga acctcaggta 480
atgtatttgc tctacaaata tatgcctctg agccgcgcag ttcttacgga tgccatccag 540
ataagtcttg agagcaacag ccaggtaggg atttgctatg cctacttgat gggaggcagc 600
ctcaagggcc tagtccgtgc cccactacgt aaacgtctgc gcgccaaact acgctcgcag 660
cgcaaaaaga aggacgttct tccaccccac gacttcttac tgctgctcca gtaa 714
<210> 294
<211> 714
<212> DNA
<213> African swine fever virus
<400> 294
atgttagaaa tagtattggc aacgctgcta ggtgacctgc agcggctccg ggttcttacc 60
cctcagcagc gggcggttgc cttctttcga gccaatacta aagagctaga ggacttctta 120
tgtccagatg ggcagtctga ggaggtgctg tctggctccc tccttaaccg tctactagaa 180
ccctcaggcc ctcttgatat tttaactgga tatcacctat ttcgtcagaa tcccaaggca 240
ggtcagttgc gcggccttga ggtcaagatg cttgaacggt tatacgatgc taatatttac 300
aacatattgt cccggctgcg acctgaaaaa gttcgcaaca aggctgttga gctatactgg 360
gtttttcggg ctatcaatat gtgtcatgct cctttagttt tagatattgt acgaaatgag 420
gaactggact ttgctgaact ggcctttatt tgtgctgctt actttggtga gcctcaggta 480
atgtatttgc tctacaaata tatgcctctg acccgcgcag ttcttacgga tgccatccag 540
ataagtcttg agagcaacag ccaggtgggg atttgctatg cctacttgat gggaggcagc 600
ctcaagggac tagtccgtgc cccgctacgt aaacgtctgc gcgccaaact acgctcgcag 660
cgcaaaaaga aggatgttct tccaccccac gacttcttac tgctgctcca gtaa 714
<210> 295
<211> 774
<212> DNA
<213> African swine fever virus
<400> 295
atgcaaaata aaatcccaaa ttttaacctt ttcttttttt ttctatacaa gatgttagaa 60
atagtattgg caacgctgct gggtgatctg cagcaactta aggatcttac acctaagcag 120
cgggccgtag ctttcttccg agccaacacc aaagagctag aggactttct ctaccccgat 180
gggcagactg aggagttact ccctggattt cttcttaacc atttactaga accctcaggc 240
cctattgaaa ttttaaccgg atatcacctc tttcgtcaga atccaaaggc aggtcgcttg 300
cgaggccttg aggtgaaaat gcttgaacgg ttatatgatg ctaatattta caatatgctg 360
gctcggctac ggcctgagtt ggttcgtgac aaggctgttg agctatattg gctttttcga 420
gctattttaa tatgtcatgg tcccttggtt ttggagattg tacgacatga gacgttggac 480
tttgcagaaa ccgcctttat ctgtgctgct tactttagtg aacctcaggt aatgtacgct 540
ctttataact ttataccacc cactcatgca gtccttgctg atgccatcca gatgtgtctt 600
gagagcaaca gcgaggcagg gatttgctat gtctacctaa tgggaggtaa cctcaagggc 660
aaggtgcccg gctcgctgcg caaacgtctg cgtgccagtc cacttcggca agaacgcaaa 720
aagaaaaacg tccttccgcc ccacgaattc ctactcctgc tccacgggat ttaa 774
<210> 296
<211> 774
<212> DNA
<213> African swine fever virus
<400> 296
atgcaaaata aaatcccaaa ttttaacctt ttcttttttt ttctatacaa gatgttagaa 60
atagtattgg ccacgctgct aggtgatctg cagaaactta aggatcttac acctccgcag 120
cgggctgtgg ctttctttcg agccaacacc aaagagctag aggactttct ctaccccgat 180
gggcagtctg aggagttact ccctggactt ctccttaacc gtttactaga accttcaggt 240
tctattgaca ttttaaccgg ttaccaccta tttcgtgaga atccaaaggc aggtcgcttg 300
cgaggccttg aggtgaaaat gcttgaacgg ttatatgatg ctaatattta caatatgctg 360
gctcggctac ggcctgagtt ggttcgtgac aaggctattg agctatattg gctctttcgg 420
gctattttaa tgtgtcatag tcccttagtt ttggagattg tacgacatga gacaatggat 480
tttgcagaaa ccgcctttat ctgtgccgct tactttagtg aacctcaggt aatgtacgct 540
ctttataaat ttatacctat ctctcgtgca gtccttgctg atgccattca gatgtgtctt 600
gagagcaaca gcgaggcggg gatttgctat gcttacctaa tggggggtag cctcaagggc 660
aaggtgcctg gctcgctgcg caaacgtctg cgtgccagtc cacttcggca agagcgcaaa 720
aagaaaaacg tcctcccgcc ccatgaattc ctactcatgc tccatgggat ttaa 774
<210> 297
<211> 765
<212> DNA
<213> African swine fever virus
<400> 297
atgcaaaata aaatcccaaa ttttaacctt ttcttttttt ttctatacag gatgttagaa 60
atagtattgg caacgctgct aggtgacctg cagcggctcc gggttcttac ccctcagcag 120
cgggcggttg ccttctttcg agccaatact aaggagctag aggacttctt atgctcagat 180
gggcagtctg aggagatact gtccggcccc ctccttaacc gtctactaga accctcaggc 240
cctcttgata ttttaaccgg atatcactta tttcgtcaga atcccaaggc aggtcagttg 300
cgcggtcttg aggtcaagat gcttgaacgg ttatacgatg ctaatattta caatatattg 360
tctcggctgc gacctgaaaa agttcgcaac aaggctattg agctatactg ggttttccga 420
gctatccata tttgtcatgc tcctttagtt ttagatattg tacgatatga ggaaccggac 480
tttgctgaac tggcctttat ttgtgctgct tactttggtg aacctcaggt aatgtatttg 540
ctctacaaat atatgcctct gacccgcgca gttcttacgg atgccatccg gataagtctt 600
gagagtaaca accaggtagg gatttgctat gcttacttga tgggaggcag cctcaaggga 660
ctagtctccg ccccactgcg taaacgtctg cgcgccaaac tacgctcaca gcgcaaaaag 720
aaagacgttc tttcacccca cgacttctta ctgctgctcc agtaa 765
<210> 298
<211> 765
<212> DNA
<213> African swine fever virus
<400> 298
atgcaaaata aaatcccaaa ttttaacctt ttcttttttt ttctatacag gatgttagaa 60
atagtattgg caacgctgct aggcgacctg cagcggctcc gggttcttac ccctcagcag 120
cgggcggttg ccttctttcg agccaatact aaggagctag aggacttctt atgctcagat 180
gggcagtctg aggagatact atctggcccc cttcttaacc gtctactaga accctcaggc 240
cctcttgata ttttaactgg atatcaccta tttcgtcaga accccaaggc aggtcagtta 300
cgcggccttg aggtcaagat gcttgaacgg ttatacgatg ctaatattta caatatattg 360
tctcggctgc gacctgaaaa agttcgcaac aaggctattg agctttactg ggtttttcga 420
gctatccata tttgtcatgc tcctttagtt ttagatattg tacgatatga ggaaccggac 480
tttgctgaac tggcctttat ttgtgctgct tactttggtg aacctcaggt aatgtatttg 540
ctctacaaat atatgcctct gacccgcgca gttcttacgg atgccatccg gataagtctt 600
gagagtaaca accaggtagg gatttgctat gcttacttga tgggaggcag cctcaaggga 660
ctagtctccg ccccactgcg taaacgtctg tgcgccaaac tacgctcgca gcgcaaaaag 720
aaggacgttc tttcacccca cgacttctta ctgctgctcc agtaa 765
<210> 299
<211> 774
<212> DNA
<213> African swine fever virus
<400> 299
atgcaaaata aaatcccaaa ttttaacctt ttcttttttt ttctatacaa gatgttagaa 60
atagtattgg caacgctgct aggtgatctg cagaaactta aagatcttac acctatgcag 120
cgggctgtgg ctttctttcg agccaacact aaagagctag aggacttcct ctgccccgat 180
gggcagtctg aggagttact ccctggactt ctccttaacc gtttattaga accttcaggt 240
cctattgaca ttttaaccgg ttaccaccta tttcgtgaga atccgaaggc aggtcggctg 300
cgtggccttg aggtcaagct gcttgaacgg ttatatgatg ctaacatcta caatatattg 360
gcccagctac ggcctgagtt ggttcgcaat aaggctgttg agttatattg gctctttcgg 420
gctattttga tgtgtcatgg tcccttagtt ttggagattg tacgacatga gacaatggat 480
tttgcagaat tagcctttat ctgtgctgct tactttagtg aacctcaggt aatgtacgct 540
atttataaat ttatacctat ctcttgcgca gtccttgctg atgccattca gatgtgtctt 600
gagagtaaca gcgaggcggg gatttgctat gcttacctaa tggggggtag cctcaagggc 660
aaggtgcctg gcgcgctgcg caaacgtctg cgtgccagtc cacttcggca agagcgcaaa 720
aagaaaaacg ttcttccacc ccatgaattc ctactcatgc ttcatgggat ttaa 774
<210> 300
<211> 723
<212> DNA
<213> African swine fever virus
<400> 300
atgttagaaa tagtattggc aacgctgcta ggtgatctgc agaagcttag ggatcttaca 60
cctatgcagc gggctgtggc tttctttcga gtcaacacta aagagctaga ggacttcctc 120
taccccgatg ggcagtctga ggagttgctc cctggacttc tccttaaccg tttactagaa 180
ccttcaggcc ctattgacat tttaaccggt taccacctat ttcgtgagaa cccaaaggca 240
ggtcggctgc gtggccttga ggttaagctg cttgaacggt tatatgatgc taacatctac 300
aatatgttgg cccaaatacg acctgagttg gttcgtatca aggctattga gttatattgg 360
ctctttcggg ctattttaat gtgtcatagt cccttagttt tggagattgt acgacatgag 420
acaatggatt ttgcagaatt agcctttatc tgtgctgctt actttagtga acctcaggta 480
atgtacgctc tttataaatt tatacctatt tctcgcgcag tccttgctga tgccatcgag 540
atgtctcttg agagcaacag cgagacgggg atttgctatg cctacctaat ggggggtagc 600
ctcaagggca aggtgcccgg cccgctgcgc aaacgtctgc gtgccagtcc acttcggcaa 660
gagcgcaaaa agaaaaacgt ccttccgccc catgaatttc tactcatgct ccatgggatt 720
taa 723
<210> 301
<211> 237
<212> PRT
<213> African swine fever virus
<400> 301
Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Arg Leu
1 5 10 15
Arg Val Leu Thr Pro Gln Gln Arg Ala Val Ala Phe Phe Arg Ala Asn
20 25 30
Thr Lys Glu Leu Glu Asp Phe Leu Cys Ser Asp Gly Gln Ser Glu Glu
35 40 45
Val Leu Ser Gly Pro Leu Leu Asn Arg Leu Leu Glu Pro Ser Gly Pro
50 55 60
Leu Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Gln Asn Pro Lys Ala
65 70 75 80
Gly Gln Leu Arg Gly Leu Glu Val Lys Met Leu Glu Arg Leu Tyr Asp
85 90 95
Ala Asn Ile Tyr Asn Ile Leu Ser Arg Leu Arg Pro Glu Lys Val Arg
100 105 110
Asn Lys Ala Ile Glu Leu Tyr Trp Val Phe Arg Ala Ile His Ile Cys
115 120 125
His Ala Pro Leu Val Leu Asp Ile Val Arg Tyr Glu Glu Pro Asp Phe
130 135 140
Ala Glu Leu Ala Phe Ile Cys Ala Ala Tyr Phe Gly Glu Pro Gln Val
145 150 155 160
Met Tyr Leu Leu Tyr Lys Tyr Met Pro Leu Thr Arg Ala Val Leu Thr
165 170 175
Asp Ala Ile Arg Ile Ser Leu Glu Ser Asn Asn Gln Val Gly Ile Cys
180 185 190
Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Leu Val Ser Ala Pro
195 200 205
Leu Arg Lys Arg Leu Arg Ala Lys Leu Arg Ser Gln Arg Lys Lys Lys
210 215 220
Asp Val Leu Ser Pro His Asp Phe Leu Leu Leu Leu Gln
225 230 235
<210> 302
<211> 237
<212> PRT
<213> African swine fever virus
<400> 302
Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Arg Leu
1 5 10 15
Arg Val Leu Thr Pro Gln Gln Arg Ala Val Ala Phe Phe Arg Ala Asn
20 25 30
Thr Lys Glu Leu Glu Asp Phe Leu Cys Ser Asp Gly Gln Ser Glu Glu
35 40 45
Val Leu Ser Gly Pro Leu Leu Asn Arg Leu Leu Glu Pro Ser Gly Pro
50 55 60
Leu Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Gln Asn Pro Lys Ala
65 70 75 80
Gly Gln Leu Arg Gly Leu Glu Val Lys Met Leu Glu Arg Leu Tyr Asp
85 90 95
Ala Asn Ile Tyr Asn Ile Leu Ser Arg Leu Arg Pro Glu Lys Val Arg
100 105 110
Asn Lys Ala Ile Glu Leu Tyr Trp Val Phe Arg Ala Ile His Ile Cys
115 120 125
His Ala Pro Leu Val Leu Asp Ile Val Arg Tyr Glu Glu Pro Asp Phe
130 135 140
Ala Glu Leu Ala Phe Ile Cys Ala Ala Tyr Phe Gly Glu Pro Gln Val
145 150 155 160
Met Tyr Leu Leu Tyr Lys Tyr Met Pro Leu Thr Arg Ala Val Leu Thr
165 170 175
Asp Ala Ile Arg Ile Ser Leu Glu Ser Asn Asn Gln Val Gly Ile Cys
180 185 190
Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Leu Val Ser Ala Pro
195 200 205
Leu Arg Lys Arg Leu Arg Ala Lys Leu Arg Ser Gln Arg Lys Lys Lys
210 215 220
Asp Val Leu Ser Pro His Asp Phe Leu Leu Leu Leu Gln
225 230 235
<210> 303
<211> 257
<212> PRT
<213> African swine fever virus
<400> 303
Met Gln Asn Lys Ile Pro Asn Phe Asn Leu Phe Phe Phe Phe Leu Tyr
1 5 10 15
Lys Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Lys
20 25 30
Leu Lys Asp Leu Thr Pro Met Gln Arg Ala Val Ala Phe Phe Arg Ala
35 40 45
Asn Thr Lys Glu Leu Glu Asp Phe Leu Cys Pro Asp Gly Gln Ser Glu
50 55 60
Glu Leu Leu Pro Gly Leu Leu Leu Asn Arg Leu Leu Glu Pro Ser Gly
65 70 75 80
Pro Ile Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Glu Asn Pro Lys
85 90 95
Ala Gly Arg Leu Arg Gly Leu Glu Val Lys Leu Leu Glu Arg Leu Tyr
100 105 110
Asp Ala Asn Ile Tyr Asn Ile Leu Ala Gln Leu Arg Pro Glu Leu Val
115 120 125
Arg Asn Lys Ala Val Glu Leu Tyr Trp Leu Phe Arg Ala Ile Leu Met
130 135 140
Cys His Gly Pro Leu Val Leu Glu Ile Val Arg His Glu Thr Met Asp
145 150 155 160
Phe Ala Glu Leu Ala Phe Ile Cys Ala Ala Tyr Phe Ser Glu Pro Gln
165 170 175
Val Met Tyr Ala Ile Tyr Lys Phe Ile Pro Ile Ser Cys Ala Val Leu
180 185 190
Ala Asp Ala Ile Gln Met Cys Leu Glu Ser Asn Ser Glu Ala Gly Ile
195 200 205
Cys Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Lys Val Pro Gly
210 215 220
Ala Leu Arg Lys Arg Leu Arg Ala Ser Pro Leu Arg Gln Glu Arg Lys
225 230 235 240
Lys Lys Asn Val Leu Pro Pro His Glu Phe Leu Leu Met Leu His Gly
245 250 255
Ile
<210> 304
<211> 257
<212> PRT
<213> African swine fever virus
<400> 304
Met Gln Asn Lys Ile Pro Asn Phe Asn Leu Phe Phe Phe Phe Leu Tyr
1 5 10 15
Lys Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Gln
20 25 30
Leu Lys Asp Leu Thr Pro Lys Gln Arg Ala Val Ala Phe Phe Arg Ala
35 40 45
Asn Thr Lys Glu Leu Glu Asp Phe Leu Tyr Pro Asp Gly Gln Thr Glu
50 55 60
Glu Leu Leu Pro Gly Phe Leu Leu Asn His Leu Leu Glu Pro Ser Gly
65 70 75 80
Pro Ile Glu Ile Leu Thr Gly Tyr His Leu Phe Arg Gln Asn Pro Lys
85 90 95
Ala Gly Arg Leu Arg Gly Leu Glu Val Lys Met Leu Glu Arg Leu Tyr
100 105 110
Asp Ala Asn Ile Tyr Asn Met Leu Ala Arg Leu Arg Pro Glu Leu Val
115 120 125
Arg Asp Lys Ala Val Glu Leu Tyr Trp Leu Phe Arg Ala Ile Leu Ile
130 135 140
Cys His Gly Pro Leu Val Leu Glu Ile Val Arg His Glu Thr Leu Asp
145 150 155 160
Phe Ala Glu Thr Ala Phe Ile Cys Ala Ala Tyr Phe Ser Glu Pro Gln
165 170 175
Val Met Tyr Ala Leu Tyr Asn Phe Ile Pro Pro Thr His Ala Val Leu
180 185 190
Ala Asp Ala Ile Gln Met Cys Leu Glu Ser Asn Ser Glu Ala Gly Ile
195 200 205
Cys Tyr Val Tyr Leu Met Gly Gly Asn Leu Lys Gly Lys Val Pro Gly
210 215 220
Ser Leu Arg Lys Arg Leu Arg Ala Ser Pro Leu Arg Gln Glu Arg Lys
225 230 235 240
Lys Lys Asn Val Leu Pro Pro His Glu Phe Leu Leu Leu Leu His Gly
245 250 255
Ile
<210> 305
<211> 254
<212> PRT
<213> African swine fever virus
<400> 305
Met Gln Asn Lys Ile Pro Asn Phe Asn Leu Phe Phe Phe Phe Leu Tyr
1 5 10 15
Arg Met Leu Glu Ile Val Leu Ala Thr Leu Leu Gly Asp Leu Gln Arg
20 25 30
Leu Arg Val Leu Thr Pro Gln Gln Arg Ala Val Ala Phe Phe Arg Ala
35 40 45
Asn Thr Lys Glu Leu Glu Asp Phe Leu Arg Ser Asp Gly Gln Ser Glu
50 55 60
Glu Ile Leu Ser Gly Pro Leu Leu Asn Arg Leu Leu Glu Pro Ser Cys
65 70 75 80
Pro Leu Asp Ile Leu Thr Gly Tyr His Leu Phe Arg Gln Asn Pro Lys
85 90 95
Ala Gly Gln Leu Arg Gly Leu Glu Val Lys Met Leu Glu Arg Leu Tyr
100 105 110
Asp Ala Asn Ile Tyr Asn Ile Leu Ser Arg Leu Arg Pro Glu Lys Val
115 120 125
Arg Asn Lys Ala Ile Glu Leu Tyr Trp Val Phe Arg Ala Ile His Ile
130 135 140
Cys His Ala Pro Leu Val Leu Asp Ile Val Arg Tyr Glu Glu Pro Asp
145 150 155 160
Phe Ala Glu Leu Ala Phe Ile Cys Ala Ala Tyr Phe Gly Glu Pro Gln
165 170 175
Val Met Tyr Leu Leu Tyr Lys Tyr Met Pro Leu Thr Arg Ala Val Leu
180 185 190
Thr Asp Ala Ile Gln Ile Ser Leu Glu Ser Asn Asn Gln Val Gly Ile
195 200 205
Cys Tyr Ala Tyr Leu Met Gly Gly Ser Leu Lys Gly Leu Val Ser Ala
210 215 220
Pro Leu Arg Lys Arg Leu Arg Ala Lys Leu Arg Ser Gln Arg Lys Lys
225 230 235 240
Lys Asp Val Leu Ser Pro His Asp Phe Leu Leu Leu Leu Gln
245 250
<210> 306
<211> 123
<212> PRT
<213> African swine fever virus
<400> 306
Met Leu Val Ile Phe Leu Gly Leu Leu Gly Leu Leu Ala Asn Gln Val
1 5 10 15
Leu Gly Leu Pro Asn Gln Pro Ala Gly Gln Leu His Pro Thr Asp Asn
20 25 30
Pro Pro Lys Glu Glu Leu Gly Tyr Trp Cys Thr Tyr Thr Glu Ser Cys
35 40 45
Lys Phe Cys Trp Asn Cys Gln Asn Gly Leu Cys Glu Gly Lys Leu Glu
50 55 60
Asn Thr Thr Ile Leu Glu Asn Glu Tyr Val Gln Ser Cys Ile Val Ser
65 70 75 80
Arg Trp Leu Asn Lys Cys Met Tyr Asp Leu Gly Gln Gly Ile Asp His
85 90 95
Val Met Ala Cys Ser Glu Pro Lys Pro Trp Asn Pro Tyr Lys Ile Leu
100 105 110
Lys Arg Glu Trp Lys Lys Asn Val Ser Gln Asn
115 120
<210> 307
<211> 123
<212> PRT
<213> African swine fever virus
<400> 307
Met Leu Val Ile Phe Leu Gly Leu Leu Gly Leu Leu Ala Asn Gln Val
1 5 10 15
Leu Gly Leu Pro Asn Gln Pro Ala Gly Gln Leu His Pro Thr Asp Asn
20 25 30
Pro Pro Lys Glu Glu Leu Gly Tyr Trp Cys Thr Tyr Thr Glu Ser Cys
35 40 45
Lys Phe Cys Trp Asn Cys Gln Asn Gly Leu Cys Glu Gly Lys Leu Glu
50 55 60
Asn Thr Thr Ile Leu Glu Asn Glu Tyr Val Gln Ser Cys Ile Val Ser
65 70 75 80
Arg Trp Leu Asn Lys Cys Met Tyr Asp Leu Gly Gln Gly Ile His His
85 90 95
Val Met Pro Cys Ser Glu Pro Lys Pro Trp Asn Pro Tyr Lys Ile Leu
100 105 110
Lys Lys Glu Trp Lys Glu Asn Val Ser Gln Asn
115 120
<210> 308
<211> 120
<212> PRT
<213> African swine fever virus
<400> 308
Met Leu Val Ile Phe Leu Gly Ile Leu Gly Leu Leu Ala Asn Gln Val
1 5 10 15
Ser Ser Gln Leu Val Gly Gln Leu His Pro Thr Glu Asn Pro Ser Glu
20 25 30
Asn Glu Leu Glu Tyr Trp Cys Thr Tyr Met Glu Cys Cys Gln Phe Cys
35 40 45
Trp Asp Cys Gln Asp Gly Leu Cys Val Asn Lys Leu Gly Asn Thr Thr
50 55 60
Ile Leu Glu Asn Glu Tyr Val His Pro Cys Ile Val Ser Arg Trp Leu
65 70 75 80
Asn Lys Cys Met Tyr Asp Leu Gly Gln Gly Ile Asp His Val Met Val
85 90 95
Cys Ser Gln Pro Lys Tyr Trp Asn Pro Tyr Lys Ile Leu Lys Lys Glu
100 105 110
Trp Lys Glu Asn Asn Ser Gln Asn
115 120
<210> 309
<211> 120
<212> PRT
<213> African swine fever virus
<400> 309
Met Leu Val Ile Phe Leu Gly Ile Leu Gly Leu Leu Ala Asn Gln Val
1 5 10 15
Ser Ser Gln Leu Val Gly Gln Leu His Pro Thr Glu Asn Pro Ser Glu
20 25 30
Asn Glu Leu Glu Tyr Trp Cys Thr Tyr Met Glu Cys Cys Gln Phe Cys
35 40 45
Trp Asp Cys Gln Asp Gly Leu Cys Val Asn Lys Leu Gly Asn Thr Thr
50 55 60
Ile Leu Glu Asn Glu Tyr Val His Pro Cys Ile Val Ser Arg Trp Leu
65 70 75 80
Asn Lys Cys Met Tyr Asp Leu Gly Gln Gly Ile Asp His Val Met Val
85 90 95
Cys Ser Gln Pro Lys Tyr Trp Asn Pro Tyr Lys Ile Leu Lys Lys Glu
100 105 110
Trp Lys Glu Asn Asn Ser Gln Asn
115 120
<210> 310
<211> 121
<212> PRT
<213> African swine fever virus
<400> 310
Met Leu Val Ile Phe Leu Gly Ile Leu Gly Leu Leu Ala Asn Gln Val
1 5 10 15
Ser Ser Gln Leu Val Gly Gln Leu His Pro Thr Glu Asn Pro Ser Glu
20 25 30
Asn Glu Leu Glu Tyr Trp Cys Thr Tyr Met Glu Cys Cys Gln Phe Cys
35 40 45
Trp Asp Cys Gln Asn Gly Leu Cys Val Asn Lys Leu Gly Asn Thr Thr
50 55 60
Ile Leu Glu Asn Glu Tyr Val His Pro Cys Ile Val Ser Arg Trp Leu
65 70 75 80
Asn Lys Cys Met Tyr Asp Leu Gly Gln Gly Ile Asp His Val Met Val
85 90 95
Cys Ser Gln Pro Lys Tyr Trp Asn Pro Tyr Lys Ile Leu Lys Lys Glu
100 105 110
Trp Lys Glu Asn Asn Ser Gln Asn Lys
115 120
<210> 311
<211> 118
<212> PRT
<213> African swine fever virus
<400> 311
Met Leu Val Ile Phe Leu Gly Ile Leu Gly Leu Leu Val Asn Gln Val
1 5 10 15
Ser Ser Gln Pro Val Gly Gln Leu His Pro Thr Glu Asn Pro Ser Glu
20 25 30
Asn Glu Leu Glu Tyr Trp Cys Thr Tyr Met Glu Cys Cys Gln Phe Cys
35 40 45
Trp Asp Cys Gln Asn Gly Leu Cys Val Asn Lys Leu Gly Asn Thr Thr
50 55 60
Ile Leu Glu Asn Glu Tyr Val His Pro Cys Ile Val Ser Arg Trp Leu
65 70 75 80
Asn Lys Cys Met Tyr Asp Leu Gly Gln Gly Ile Asp His Val Met Val
85 90 95
Cys Ser Gln Pro Lys Tyr Trp Asn Pro Tyr Lys Ile Leu Lys Lys Glu
100 105 110
Trp Lys Glu Asn Asn Ser
115
<210> 312
<211> 121
<212> PRT
<213> African swine fever virus
<400> 312
Met Leu Val Ile Phe Leu Gly Ile Leu Gly Leu Leu Ala Asn Gln Val
1 5 10 15
Ser Ser Gln Leu Val Gly Gln Leu His Pro Thr Glu Asn Pro Ser Glu
20 25 30
Asn Glu Leu Glu Tyr Trp Cys Thr Tyr Met Glu Cys Cys Gln Phe Cys
35 40 45
Trp Asp Cys Gln Asn Gly Leu Cys Val Asn Lys Leu Gly Asn Thr Thr
50 55 60
Ile Leu Glu Asn Glu Tyr Val His Pro Cys Ile Val Ser Arg Trp Leu
65 70 75 80
Asn Lys Cys Met Tyr Asp Leu Gly Gln Gly Ile Asp His Val Met Val
85 90 95
Cys Ser Gln Pro Lys Tyr Trp Asn Pro Tyr Lys Ile Leu Lys Lys Glu
100 105 110
Trp Lys Glu Asn Asn Ser Gln Asn Lys
115 120
<210> 313
<211> 121
<212> PRT
<213> African swine fever virus
<400> 313
Met Leu Val Ile Phe Leu Gly Ile Leu Gly Leu Leu Ala Asn Gln Val
1 5 10 15
Ser Ser Gln Leu Val Gly Gln Leu His Pro Thr Glu Asn Pro Ser Glu
20 25 30
Asn Glu Leu Glu Tyr Trp Cys Thr Tyr Met Glu Cys Cys Gln Phe Cys
35 40 45
Trp Asp Cys Gln Asn Gly Leu Cys Val Asn Lys Leu Gly Asn Thr Thr
50 55 60
Ile Leu Glu Asn Glu Tyr Val His Pro Cys Ile Val Ser Arg Trp Leu
65 70 75 80
Asn Lys Cys Met Tyr Asp Leu Gly Gln Gly Ile Asp His Val Met Val
85 90 95
Cys Ser Gln Pro Lys Tyr Trp Asn Pro Tyr Lys Ile Leu Lys Lys Glu
100 105 110
Trp Lys Glu Asn Asn Ser Gln Asn Lys
115 120
<210> 314
<211> 205
<212> PRT
<213> African swine fever virus
<400> 314
Met Leu Val Ile Phe Leu Gly Ile Leu Gly Leu Leu Ala Ser Gln Val
1 5 10 15
Ser Ser Gln Leu Val Gly Gln Leu Arg Pro Thr Glu Glu Pro Pro Glu
20 25 30
Glu Glu Leu Glu Tyr Trp Cys Ala Tyr Met Glu Ser Cys Gln Phe Cys
35 40 45
Trp Asp Cys Gln Asp Gly Thr Cys Ile Asn Lys Ile Asp Gly Ser Val
50 55 60
Ile Tyr Lys Asn Glu Tyr Val Lys Ser Cys Leu Val Ser Arg Trp Leu
65 70 75 80
Asp Lys Cys Met Tyr Asp Leu Asp Lys Gly Ile Tyr His Thr Met Asn
85 90 95
Cys Asn Gln Val Leu Gly Leu Pro Asn Gln Pro Ala Gly Gln Leu His
100 105 110
Pro Thr Asp Asn Pro Pro Gln Glu Glu Leu Glu Tyr Trp Cys Thr Tyr
115 120 125
Thr Glu Asn Cys Lys Phe Cys Trp Asn Cys Gln Asn Gly Leu Cys Glu
130 135 140
Gly Lys Leu Glu Asn Thr Thr Ile Leu Glu Asn Glu Tyr Val Gln Ser
145 150 155 160
Cys Ile Val Ser Arg Trp Leu Asn Lys Cys Met Tyr Asp Leu Gly Gln
165 170 175
Gly Ile His His Val Met Ala Cys Ser Glu Pro Lys Pro Trp Asn Pro
180 185 190
Tyr Lys Ile Leu Lys Arg Glu Trp Lys Glu Asn Asn Ser
195 200 205
<210> 315
<211> 205
<212> PRT
<213> African swine fever virus
<400> 315
Met Leu Val Ile Phe Leu Gly Ile Leu Gly Leu Leu Ala Ser Gln Val
1 5 10 15
Ser Ser Gln Leu Val Gly Gln Leu Arg Pro Thr Glu Glu Pro Pro Glu
20 25 30
Glu Glu Leu Glu Tyr Trp Cys Ala Tyr Met Glu Ser Cys Gln Phe Cys
35 40 45
Trp Asp Cys Gln Asp Gly Thr Cys Ile Asn Lys Ile Asp Gly Ser Val
50 55 60
Ile Tyr Lys Asn Glu Tyr Val Lys Ser Cys Leu Val Ser Arg Trp Leu
65 70 75 80
Asp Lys Cys Met Tyr Asp Leu Asp Lys Gly Ile Tyr His Thr Met Asn
85 90 95
Cys Asn Gln Val Leu Gly Leu Pro Asn Gln Pro Ala Gly Gln Leu His
100 105 110
Pro Thr Asp Asn Pro Pro Gln Glu Glu Leu Glu Tyr Trp Cys Thr Tyr
115 120 125
Thr Glu Asn Cys Lys Phe Cys Trp Asn Cys Gln Asn Gly Leu Cys Glu
130 135 140
Gly Lys Leu Glu Asn Thr Thr Ile Leu Glu Asn Glu Tyr Val Gln Ser
145 150 155 160
Cys Ile Val Ser Arg Trp Leu Asn Lys Cys Met Tyr Asp Leu Gly Gln
165 170 175
Gly Ile His His Val Met Ala Cys Ser Glu Pro Lys Pro Trp Asn Pro
180 185 190
Tyr Lys Ile Leu Lys Arg Glu Trp Lys Glu Asn Asn Ser
195 200 205
<210> 316
<211> 103
<212> PRT
<213> African swine fever virus
<400> 316
Met Lys Val Phe Leu Gly Leu Leu Leu Gly Tyr Ser Thr Ile Leu Ile
1 5 10 15
Leu Thr Tyr Gln Ser Pro Thr Thr Gln Trp Cys Phe Tyr Glu Ile Ser
20 25 30
Leu Lys Ile Leu Asn His His Ser Met Glu Lys Trp Arg Asp Lys Asn
35 40 45
Trp Ser Ile Ile Ile Arg Tyr Tyr Cys Phe Tyr Leu Val Phe Ser Phe
50 55 60
Ala Phe Ala Gly Cys Val Ala Phe Ala Ile Cys Lys Asn Leu Arg Leu
65 70 75 80
Cys Thr Thr Met Lys Leu Leu Met Leu Leu Asn Ile Leu Val Leu Leu
85 90 95
Ser Gln Pro Ile Leu Asn Asn
100
<210> 317
<211> 119
<212> PRT
<213> African swine fever virus
<400> 317
Met Lys Val Phe Leu Gly Leu Leu Leu Gly Tyr Ser Thr Ile Leu Ile
1 5 10 15
Leu Thr Tyr Gln Ser Pro Thr Thr Pro Trp Cys Phe Tyr Glu Ile Ser
20 25 30
Leu Lys Ile Pro Asn His His Ser Met Lys Cys Cys Ser Tyr Pro Arg
35 40 45
Leu Tyr Glu His Glu Met Phe Met Glu Lys Trp Arg Asp Lys Asn Trp
50 55 60
Pro Ile Ile Ile Arg Tyr Tyr Cys Phe Tyr Leu Val Phe Ser Phe Val
65 70 75 80
Phe Ala Gly Cys Val Ala Phe Ala Ile Cys Lys Asn Leu Arg Leu Ser
85 90 95
Thr Thr Met Lys Leu Leu Met Leu Leu Ser Ile Leu Val Leu Leu Leu
100 105 110
Ser Gln Pro Ile Leu Asn Asn
115
<210> 318
<211> 119
<212> PRT
<213> African swine fever virus
<400> 318
Met Lys Val Phe Leu Gly Leu Leu Leu Gly Tyr Ser Thr Ile Leu Ile
1 5 10 15
Leu Thr Tyr Gln Ser Pro Thr Thr Pro Trp Cys Phe Tyr Glu Ile Ser
20 25 30
Leu Lys Ile Pro Asn His His Ser Met Lys Cys Cys Ser Tyr Pro Arg
35 40 45
Leu Tyr Glu His Glu Met Phe Met Glu Lys Trp Arg Asp Lys Asn Trp
50 55 60
Pro Ile Ile Ile Arg Tyr Tyr Cys Phe Tyr Leu Val Phe Ser Phe Val
65 70 75 80
Phe Ala Gly Cys Val Ala Phe Ala Ile Cys Lys Asn Leu Arg Leu Ser
85 90 95
Thr Thr Met Lys Leu Leu Met Leu Leu Ser Ile Leu Val Leu Leu Leu
100 105 110
Ser Gln Pro Ile Leu Asn Asn
115
<210> 319
<211> 168
<212> PRT
<213> African swine fever virus
<400> 319
Met Lys Val Phe Leu Gly Leu Leu Leu Gly Phe Ser Ile Ile Leu Ile
1 5 10 15
Leu Thr Tyr Gln Ser Pro Thr Thr Gln His Pro Pro Lys Glu Glu Leu
20 25 30
Ala Tyr Trp Cys Thr Tyr Ala Lys Ser Cys Asp Phe Cys Trp Asp Cys
35 40 45
Gln Asn Asp Thr Cys Ile Asn Lys Val Ile Asn Glu Ser Ile Ser Ile
50 55 60
Thr Ser Ile Val Asn Cys Arg Val Thr Arg Asp Ser Gln Ser Cys Phe
65 70 75 80
Tyr Glu Ile Ser Val Lys Ile Pro Asn His His Ser Met Glu Cys Ser
85 90 95
Tyr Pro Arg Leu Tyr Glu His Glu Met Phe Met Glu Lys Trp Arg Asp
100 105 110
Glu Tyr Trp Pro Ile Ile Ile Lys Gln Cys Cys Phe Tyr Leu Val Phe
115 120 125
Ser Ile Ala Phe Ala Gly Cys Val Ala Phe Ala Ile Cys Lys Asn Leu
130 135 140
Arg Leu Arg Thr Thr Ile Lys Leu Leu Ile Leu Leu Ser Ile Leu Val
145 150 155 160
Trp Leu Ser Gln Pro Val Leu Asn
165
<210> 320
<211> 171
<212> PRT
<213> African swine fever virus
<400> 320
Met Lys Val Phe Leu Ala Leu Leu Leu Gly Tyr Leu Thr Ile Leu Ile
1 5 10 15
Leu Thr Tyr Gln Thr Pro Thr Thr Gln His Pro Pro Lys Glu Glu Leu
20 25 30
Pro Tyr Trp Cys Thr Tyr Val Lys Asn Cys Asp Leu Cys Trp Asp Cys
35 40 45
Gln Asp Ser Ile Tyr Trp Asn Lys Val Ile Ser Glu Ser Ile Ser Ile
50 55 60
Asn Ser Ile Ile Asn Cys Arg Val Thr Cys Asp Ser Gln Ser Gln Ser
65 70 75 80
Cys Phe Tyr Glu Ile Leu Leu Lys Ile Pro Asn His His Ser Met Glu
85 90 95
Cys Ser Tyr Pro Gly Ser Tyr Glu Asn Glu Met Phe Met Glu Lys Trp
100 105 110
Arg Asp Glu Asn Trp Ser Ile Ile Ile Lys His Tyr Cys Phe Tyr Leu
115 120 125
Val Phe Ser Phe Ala Phe Ala Gly Cys Val Ala Phe Ala Ile Cys Lys
130 135 140
Asn Leu Arg Leu Ser Thr Thr Met Lys Leu Leu Met Leu Leu Ser Ile
145 150 155 160
Leu Val Cys Leu Ser Gln Pro Ile Leu Asn Asn
165 170
<210> 321
<211> 169
<212> PRT
<213> African swine fever virus
<400> 321
Met Lys Val Phe Leu Gly Leu Leu Leu Gly Phe Ser Ile Ile Leu Ile
1 5 10 15
Leu Thr Tyr Gln Ser Pro Thr Thr Gln His Pro Pro Lys Glu Glu Leu
20 25 30
Ala Tyr Trp Cys Thr Tyr Ala Lys Ser Cys Asp Phe Cys Trp Asp Cys
35 40 45
Gln Asn Asp Thr Cys Ile Asn Lys Val Ile Asn Glu Ser Ile Ser Ile
50 55 60
Thr Ser Ile Val Asn Cys Arg Val Thr Arg Asp Ser Gln Ser Cys Phe
65 70 75 80
Tyr Asp Ile Ser Val Lys Ile Pro Asn His His Ser Met Glu Cys Ser
85 90 95
Tyr Pro Arg Leu Tyr Glu His Glu Met Phe Met Glu Lys Trp Arg Asp
100 105 110
Glu Tyr Trp Pro Ile Ile Ile Lys Gln Cys Cys Phe Tyr Leu Val Phe
115 120 125
Ser Phe Ala Phe Ala Gly Cys Val Ala Phe Ala Ile Cys Lys Asn Leu
130 135 140
Arg Leu Arg Thr Thr Ile Lys Leu Leu Ile Leu Leu Ser Ile Leu Val
145 150 155 160
Trp Leu Ser Gln Pro Ile Leu Asn Asn
165
<210> 322
<211> 103
<212> PRT
<213> African swine fever virus
<400> 322
Met Lys Val Phe Leu Gly Leu Leu Leu Gly Tyr Ser Thr Ile Leu Ile
1 5 10 15
Leu Thr Tyr Gln Ser Pro Thr Thr Gln Trp Cys Phe Tyr Glu Ile Ser
20 25 30
Leu Lys Ile Leu Asn His His Ser Met Glu Lys Trp Arg Asp Lys Asn
35 40 45
Trp Ser Ile Ile Ile Arg Tyr Tyr Cys Phe Tyr Leu Val Phe Ser Phe
50 55 60
Ala Phe Ala Gly Cys Val Ala Phe Ala Ile Cys Lys Asn Leu Arg Leu
65 70 75 80
Cys Thr Thr Met Lys Leu Leu Met Leu Leu Asn Ile Leu Val Leu Leu
85 90 95
Ser Gln Pro Ile Leu Asn Asn
100
<210> 323
<211> 171
<212> PRT
<213> African swine fever virus
<400> 323
Met Lys Val Phe Leu Gly Leu Leu Leu Gly Tyr Ser Thr Ile Leu Ile
1 5 10 15
Leu Thr Tyr Gln Ser Pro Thr Thr Gln His Pro Pro Lys Glu Glu Leu
20 25 30
Glu Tyr Trp Cys Thr Tyr Ala Lys Thr Cys Asp Phe Cys Trp Asp Cys
35 40 45
Gln Asn Asp Thr Cys Ile Asn Lys Val Ile Asn Glu Ser Ile Ser Met
50 55 60
Asn Ser Ile Val Asn Cys Arg Val Thr Arg Asp Ser Gln Ser Gln Ser
65 70 75 80
Cys Phe Tyr Glu Ile Ser Leu Lys Ile Pro Asn Tyr His Ser Met Glu
85 90 95
Cys Ser Tyr Pro Arg Leu Tyr Lys His Phe Met Ser Met Glu Lys Trp
100 105 110
Arg Asp Glu Asn Trp Pro Ile Leu Ile Arg His Tyr Cys Phe Tyr Leu
115 120 125
Val Phe Ser Phe Ala Phe Ala Gly Cys Val Ala Phe Ala Ile Cys Lys
130 135 140
Asn Leu Arg Leu Arg Thr Thr Met Lys Leu Leu Met Leu Leu Ser Ile
145 150 155 160
Leu Val Leu Leu Ser Gln Pro Ile Leu Asn Asn
165 170
<210> 324
<211> 107
<212> PRT
<213> African swine fever virus
<400> 324
Met Asn Ala Thr Met Lys Val Phe Leu Gly Leu Leu Leu Gly Tyr Ser
1 5 10 15
Thr Ile Leu Ile Leu Thr Tyr Gln Ser Pro Thr Thr Gln Trp Cys Phe
20 25 30
Tyr Glu Ile Ser Leu Lys Ile Leu Asn His His Ser Met Glu Lys Trp
35 40 45
Arg Asp Lys Asn Trp Ser Ile Ile Ile Arg Tyr Tyr Cys Phe Tyr Leu
50 55 60
Val Phe Ser Phe Ala Phe Ala Gly Cys Val Ala Phe Ala Ile Cys Lys
65 70 75 80
Asn Leu Arg Leu Cys Thr Thr Met Lys Leu Leu Met Leu Leu Gly Ile
85 90 95
Leu Val Leu Leu Ser Gln Pro Ile Leu Asn Asn
100 105
<210> 325
<211> 117
<212> PRT
<213> African swine fever virus
<400> 325
Met Lys Val Phe Leu Gly Leu Leu Leu Gly Tyr Ser Thr Ile Leu Ile
1 5 10 15
Leu Thr Tyr Gln Ser Pro Ala Thr Gln Trp Cys Phe Tyr Glu Ile Ser
20 25 30
Leu Lys Ile Pro Asn His His Ser Met Glu Cys Ser Tyr Pro Arg Leu
35 40 45
Tyr Lys His Phe Ile Phe Met Glu Lys Trp Arg Asp Lys Asn Trp Ser
50 55 60
Ile Ile Ile Arg Tyr Tyr Cys Phe Tyr Leu Val Phe Ser Phe Ala Phe
65 70 75 80
Ala Gly Cys Ile Ala Phe Ala Ile Cys Lys Asn Leu Arg Leu Cys Thr
85 90 95
Thr Met Lys Leu Leu Met Leu Leu Ser Ile Leu Val Leu Leu Ser Gln
100 105 110
Pro Ile Leu Asn Asn
115
<210> 326
<211> 117
<212> PRT
<213> African swine fever virus
<400> 326
Met Lys Val Phe Leu Gly Leu Leu Leu Gly Tyr Ser Thr Ile Leu Ile
1 5 10 15
Leu Thr Tyr Gln Ser Pro Ala Thr Gln Trp Cys Phe Tyr Glu Ile Ser
20 25 30
Leu Lys Ile Pro Asn His His Ser Met Glu Cys Ser Tyr Pro Arg Leu
35 40 45
Tyr Lys His Phe Met Phe Met Lys Lys Trp Arg Asp Lys Asn Trp Ser
50 55 60
Ile Ile Ile Arg Tyr Tyr Cys Phe Tyr Leu Val Phe Ser Phe Ala Phe
65 70 75 80
Ala Gly Cys Ile Ala Phe Ala Ile Cys Lys Asn Leu Arg Leu Cys Thr
85 90 95
Thr Met Lys Leu Leu Met Leu Leu Ser Ile Leu Val Leu Leu Ser Gln
100 105 110
Pro Ile Leu Asn Asn
115
<210> 327
<211> 438
<212> DNA
<213> African swine fever virus
<400> 327
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac tgctccctct 360
gaagaaaaga ctaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 328
<211> 438
<212> DNA
<213> African swine fever virus
<400> 328
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg tcatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttaatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
aggctgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ctaaccatct tctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 329
<211> 438
<212> DNA
<213> African swine fever virus
<400> 329
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg tcatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttaatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
aggctgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ctaaccatct tctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 330
<211> 438
<212> DNA
<213> African swine fever virus
<400> 330
atggatcatt atcttaaaaa attacaggat atttataaga agcttgaggg tcaccccttt 60
ctttttagtc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaagccttg 120
gcctcgacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttgttaacta tattaaagcg agtaaacaag agtatttatg tctgttgatt 240
aatcctaaac tagtcactaa gtttttaaaa ataacgagct ttaaaattta cattaatttt 300
aggctgaaaa ctttttatat aagtcctaat aagtataata atttttacat cgctccctct 360
gaagaaaagg ccaatcatct cctaaaagaa gaaaaaacct gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 331
<211> 438
<212> DNA
<213> African swine fever virus
<400> 331
atggatcatt atcttaaaaa attacaggat atttataaga agcttgaggg tcaccccttt 60
ctttttagtc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaagccttg 120
gcctcgacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttgttaacta tattaaagcg agtaaacaag agtatttatg tctgttgatt 240
aatcctaaac tagtcactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
aggctaaaaa ctttctatat aagtcctaat aagtataata atttttacat cgctccctct 360
gaagaaaagg ccaatcatct cctaaaagaa gaaaaaacct gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 332
<211> 438
<212> DNA
<213> African swine fever virus
<400> 332
atggatcatt atcttaaaaa attacaggat atttataaga agcttgaggg tcaccccttt 60
ctttttagtc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaagccttg 120
gcctcgacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttgttaacta tattaaagcg agtaaacaag agtatttatg tctgttgatt 240
aatcctaaac tagtcactaa gtttttaaaa ataacgagct ttaaaattta cattaatttt 300
aggctgaaaa ctttttatat aagtcctaat aagtataata atttttacat cgctccctct 360
gaagaaaagg ccaatcatct cctaaaagaa gaaaaaacct gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 333
<211> 438
<212> DNA
<213> African swine fever virus
<400> 333
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac tgctccctct 360
gaagaaaaga ctaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 334
<211> 438
<212> DNA
<213> African swine fever virus
<400> 334
atggatcatt atcttaaaaa attagaggat atttataaaa agcttgaggg tcatcccttt 60
ctttttagtc cgtcgaaaac caatgaaaaa gagtttatta ctctgttaaa ccaagccttg 120
gcctcaacgc agctttatcg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatc 240
aatcctaaac tagttacgaa gtttttaaaa ataacgagtt ttaaaattta cattaatttc 300
aggctgaaaa ctttttatat aagtcctaat aaatataata atttttacac cgctccctct 360
gaagaaaagg ccaatcatct cctaaaagaa gaaaaaacct gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 335
<211> 441
<212> DNA
<213> African swine fever virus
<400> 335
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cctatagggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ccaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggaggag aagaatccta a 441
<210> 336
<211> 438
<212> DNA
<213> African swine fever virus
<400> 336
atggatcatt atcttaaaaa attacaagaa atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttatcg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgtcactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ccaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 337
<211> 438
<212> DNA
<213> African swine fever virus
<400> 337
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg tcatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ctaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 338
<211> 441
<212> DNA
<213> African swine fever virus
<400> 338
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cctatagggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgttactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ccaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggaggag aagaatccta a 441
<210> 339
<211> 438
<212> DNA
<213> African swine fever virus
<400> 339
atggatcatt atcttaaaaa attacaagat atttatacga agctcgaggg ccatcccttt 60
ctttttagcc cgtcgaaaac caatgaaaaa gagtttatta ctctgctaaa ccaggccttg 120
gcctcaacgc agctttaccg cagcatacaa cagctgtttt taacgatgta taagctagat 180
cccattgggt ttattaacta tattaaaacg agtaaacaag agtatttatg cctgttgatt 240
aatcctaaac tcgtcactaa gtttttaaaa ataacgagct ttaaaattta cattaatttc 300
agactgaaaa ctttttatat aagtcctaat aagtataata atttttacac cgctccctct 360
gaagaaaaga ccaaccatct cctaaaagaa gaaaaaactt gggcaaagat tgttgaagaa 420
ggaggagaag aatcctaa 438
<210> 340
<211> 145
<212> PRT
<213> African swine fever virus
<400> 340
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 341
<211> 145
<212> PRT
<213> African swine fever virus
<400> 341
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 342
<211> 145
<212> PRT
<213> African swine fever virus
<400> 342
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 343
<211> 145
<212> PRT
<213> African swine fever virus
<400> 343
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Lys Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Val Asn Tyr Ile Lys Ala Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Ile Ala Pro Ser Glu Glu Lys Ala Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 344
<211> 145
<212> PRT
<213> African swine fever virus
<400> 344
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Lys Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Val Asn Tyr Ile Lys Ala Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Ile Ala Pro Ser Glu Glu Lys Ala Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 345
<211> 145
<212> PRT
<213> African swine fever virus
<400> 345
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Lys Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Val Asn Tyr Ile Lys Ala Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Ile Ala Pro Ser Glu Glu Lys Ala Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 346
<211> 145
<212> PRT
<213> African swine fever virus
<400> 346
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 347
<211> 145
<212> PRT
<213> African swine fever virus
<400> 347
Met Asp His Tyr Leu Lys Lys Leu Glu Asp Ile Tyr Lys Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Ala Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 348
<211> 146
<212> PRT
<213> African swine fever virus
<400> 348
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Gly Glu
130 135 140
Glu Ser
145
<210> 349
<211> 145
<212> PRT
<213> African swine fever virus
<400> 349
Met Asp His Tyr Leu Lys Lys Leu Gln Glu Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 350
<211> 145
<212> PRT
<213> African swine fever virus
<400> 350
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 351
<211> 146
<212> PRT
<213> African swine fever virus
<400> 351
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Gly Glu
130 135 140
Glu Ser
145
<210> 352
<211> 145
<212> PRT
<213> African swine fever virus
<400> 352
Met Asp His Tyr Leu Lys Lys Leu Gln Asp Ile Tyr Thr Lys Leu Glu
1 5 10 15
Gly His Pro Phe Leu Phe Ser Pro Ser Lys Thr Asn Glu Lys Glu Phe
20 25 30
Ile Thr Leu Leu Asn Gln Ala Leu Ala Ser Thr Gln Leu Tyr Arg Ser
35 40 45
Ile Gln Gln Leu Phe Leu Thr Met Tyr Lys Leu Asp Pro Ile Gly Phe
50 55 60
Ile Asn Tyr Ile Lys Thr Ser Lys Gln Glu Tyr Leu Cys Leu Leu Ile
65 70 75 80
Asn Pro Lys Leu Val Thr Lys Phe Leu Lys Ile Thr Ser Phe Lys Ile
85 90 95
Tyr Ile Asn Phe Arg Leu Lys Thr Phe Tyr Ile Ser Pro Asn Lys Tyr
100 105 110
Asn Asn Phe Tyr Thr Ala Pro Ser Glu Glu Lys Thr Asn His Leu Leu
115 120 125
Lys Glu Glu Lys Thr Trp Ala Lys Ile Val Glu Glu Gly Gly Glu Glu
130 135 140
Ser
145
<210> 353
<211> 378
<212> DNA
<213> African swine fever virus
<400> 353
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctagcagaaa aaaaaaactt tttggtgtat 120
gaattgcctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag cctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacttgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 354
<211> 378
<212> DNA
<213> African swine fever virus
<400> 354
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag cctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 355
<211> 378
<212> DNA
<213> African swine fever virus
<400> 355
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag cctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 356
<211> 378
<212> DNA
<213> African swine fever virus
<400> 356
atggcggttt atgcgaagga ccttgataat aacaaagagt taaaccaaaa attgatcaac 60
gatcagctta aaatcattga cacgcttttg ctagcagaaa aaaaaaactt tttggtgtac 120
gaactacctg cccattttga cttttcctcc ggcgaccctt tgggcagtca gcgcgacatt 180
tactatgcca tcataaaaag tctcgaggag cgcggattta ctgtcaaaat atgtatgaag 240
ggagaccgcg cccttctttt catcacctgg aaaaaaatac aatccattga gatcaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcgtt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 357
<211> 378
<212> DNA
<213> African swine fever virus
<400> 357
atggcggttt atgcgaagga ccttgataat aacaaagagt taaaccaaaa attgatcaac 60
gatcagctta aaattattga cacgcttttg ctggcagaaa aaaaaaactt tttggtgtac 120
gaactacctg cccattttga cttttcctcc ggcgaccctt tgggcagtca gcgcgacatt 180
tactatgcca tcataaaaag tctcgaggag cgcggattta ctgtcaaaat atgtatgaag 240
ggagaccgcg cccttctttt catcacctgg aaaaaaatac aatccattga gatcaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcgtt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 358
<211> 378
<212> DNA
<213> African swine fever virus
<400> 358
atggcggttt atgcgaagga ccttgataat aacaaagagt taaaccaaaa attgatcaac 60
gatcagctta aaatcattga cacgcttttg ctagcagaaa aaaaaaactt tttggtgtac 120
gaactacctg cccattttga cttttcctcc ggcgaccctt tgggcagtca gcgcgacatt 180
tactatgcca tcataaaaag tctcgaggag cgcggattta ctgtcaaaat atgtatgaag 240
ggagaccgcg cccttctttt catcacctgg aaaaaaatac aatccattga gatcaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcgtt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 359
<211> 378
<212> DNA
<213> African swine fever virus
<400> 359
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctagcagaaa aaaaaaactt tttggtgtat 120
gaattgcctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag cctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacttgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 360
<211> 378
<212> DNA
<213> African swine fever virus
<400> 360
atggcagttt atgcgaaaga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcaactta aaattattga cacgctgttg ctggcagaaa aaaaaaactt tttggtgcat 120
gaactacctg cccactatga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag tctcgaggag cgcggattta ctgtcaaaat ttgtatgaaa 240
ggagatcgcg cccttctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagatgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 361
<211> 378
<212> DNA
<213> African swine fever virus
<400> 361
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctagcagaaa aaaaaaactt tttggtgtat 120
gaattgcctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag cctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacttgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 362
<211> 378
<212> DNA
<213> African swine fever virus
<400> 362
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag tctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgcg ccctcctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 363
<211> 378
<212> DNA
<213> African swine fever virus
<400> 363
atggcggtgt atgcgaagga ccttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgtgacata 180
tactatgcca tcataaaaag tcttgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgtg ccctcctttt catcacctgg aaaaaaatac aatccattga aataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaatcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 364
<211> 378
<212> DNA
<213> African swine fever virus
<400> 364
atggcggttt atgcgaagga tcttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag tctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgcg ccctcctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 365
<211> 378
<212> DNA
<213> African swine fever virus
<400> 365
atggcggttt atgcgaagga ccttgataat aacaaagagt taaaccaaaa attaattaac 60
gatcagctta aaattattga cacgctcttg ctggcagaaa aaaaaaactt tttggtgtat 120
gaactacctg ccccttttga cttttcctcc ggcgaccctt tggccagtca gcgcgacata 180
tactatgcca tcataaaaag tctcgaggag cgcgggttta ctgtcaaaat atgtatgaaa 240
ggggatcgcg ccctcctttt catcacctgg aaaaaaatac aatccattga gataaacaaa 300
aaagaagaat atctgcgcat gcacttcata caagacgaag agaaagcatt ttattgtaaa 360
tttttagagt ctagatga 378
<210> 366
<211> 125
<212> PRT
<213> African swine fever virus
<400> 366
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 367
<211> 125
<212> PRT
<213> African swine fever virus
<400> 367
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 368
<211> 125
<212> PRT
<213> African swine fever virus
<400> 368
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 369
<211> 125
<212> PRT
<213> African swine fever virus
<400> 369
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala His Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Gly Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 370
<211> 125
<212> PRT
<213> African swine fever virus
<400> 370
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala His Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Gly Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 371
<211> 125
<212> PRT
<213> African swine fever virus
<400> 371
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala His Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Gly Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 372
<211> 125
<212> PRT
<213> African swine fever virus
<400> 372
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 373
<211> 125
<212> PRT
<213> African swine fever virus
<400> 373
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val His Glu Leu Pro Ala His Tyr Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 374
<211> 125
<212> PRT
<213> African swine fever virus
<400> 374
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 375
<211> 125
<212> PRT
<213> African swine fever virus
<400> 375
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 376
<211> 125
<212> PRT
<213> African swine fever virus
<400> 376
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ser Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 377
<211> 125
<212> PRT
<213> African swine fever virus
<400> 377
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 378
<211> 125
<212> PRT
<213> African swine fever virus
<400> 378
Met Ala Val Tyr Ala Lys Asp Leu Asp Asn Asn Lys Glu Leu Asn Gln
1 5 10 15
Lys Leu Ile Asn Asp Gln Leu Lys Ile Ile Asp Thr Leu Leu Leu Ala
20 25 30
Glu Lys Lys Asn Phe Leu Val Tyr Glu Leu Pro Ala Pro Phe Asp Phe
35 40 45
Ser Ser Gly Asp Pro Leu Ala Ser Gln Arg Asp Ile Tyr Tyr Ala Ile
50 55 60
Ile Lys Ser Leu Glu Glu Arg Gly Phe Thr Val Lys Ile Cys Met Lys
65 70 75 80
Gly Asp Arg Ala Leu Leu Phe Ile Thr Trp Lys Lys Ile Gln Ser Ile
85 90 95
Glu Ile Asn Lys Lys Glu Glu Tyr Leu Arg Met His Phe Ile Gln Asp
100 105 110
Glu Glu Lys Ala Phe Tyr Cys Lys Phe Leu Glu Ser Arg
115 120 125
<210> 379
<211> 360
<212> PRT
<213> African swine fever virus
<400> 379
Met Ile Ile Leu Ile Phe Leu Ile Phe Ser Asn Ile Val Leu Ser Ile
1 5 10 15
Asp Tyr Trp Val Ser Phe Asn Lys Thr Ile Ile Leu Asp Ser Asn Ile
20 25 30
Thr Asn Asp Asn Asn Asp Ile Asn Gly Val Ser Trp Asn Phe Phe Asn
35 40 45
Asn Ser Phe Asn Thr Leu Ala Thr Cys Gly Lys Ala Gly Asn Phe Cys
50 55 60
Glu Cys Ser Asn Tyr Ser Thr Ser Ile Tyr Asn Ile Thr Asn Asn Cys
65 70 75 80
Ser Leu Thr Ile Phe Pro His Asn Asp Val Phe Asp Thr Thr Tyr Gln
85 90 95
Val Val Asp Asn Gln Ile Ile Asn Tyr Thr Ile Lys Leu Leu Thr Pro
100 105 110
Ala Thr Pro Pro Asn Ile Thr Tyr Asn Cys Thr Asn Phe Leu Ile Thr
115 120 125
Cys Lys Lys Asn Asn Gly Thr Asn Thr Asn Ile Tyr Leu Asn Ile Asn
130 135 140
Asp Thr Phe Val Lys Tyr Thr Asn Glu Ser Ile Leu Glu Tyr Asn Trp
145 150 155 160
Asn Asn Ser Asn Ile Asn Asn Phe Thr Ala Thr Cys Ile Ile Asn Asn
165 170 175
Thr Ile Ser Thr Ser Asn Glu Thr Thr Leu Ile Asn Cys Thr Tyr Leu
180 185 190
Thr Leu Ser Ser Asn Tyr Phe Tyr Thr Phe Phe Lys Leu Tyr Tyr Ile
195 200 205
Pro Leu Ser Ile Ile Ile Gly Ile Thr Ile Ser Ile Leu Leu Ile Ser
210 215 220
Ile Ile Thr Phe Leu Ser Leu Arg Lys Arg Lys Lys His Val Glu Glu
225 230 235 240
Ile Glu Ser Pro Pro Pro Glu Ser Asn Glu Glu Glu Gln Cys Gln His
245 250 255
Asp Asp Thr Thr Ser Ile His Glu Pro Ser Pro Arg Glu Pro Leu Leu
260 265 270
Pro Lys Pro Tyr Ser Arg Tyr Gln Tyr Asn Thr Pro Ile Tyr Tyr Met
275 280 285
Arg Pro Ser Thr Gln Pro Leu Asn Pro Phe Pro Leu Pro Lys Pro Cys
290 295 300
Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys Pro Cys Pro Pro Pro Lys
305 310 315 320
Pro Cys Pro Ser Ala Glu Ser Tyr Ser Pro Pro Lys Pro Leu Pro Ser
325 330 335
Ile Pro Leu Leu Pro Asn Ile Pro Pro Leu Ser Thr Gln Asn Ile Ser
340 345 350
Leu Ile His Val Asp Arg Ile Ile
355 360
<210> 380
<211> 203
<212> PRT
<213> African swine fever virus
<400> 380
Met Ile Ile Leu Ile Phe Leu Ile Phe Ser Asn Ile Val Leu Ser Ile
1 5 10 15
Asp Tyr Trp Val Ser Phe Asn Lys Thr Ile Ile Leu Asp Ser Asn Ile
20 25 30
Thr Asn Asp Asn Asn Asp Ile Asn Gly Val Ser Trp Asn Phe Phe Asn
35 40 45
Asn Ser Phe Asn Thr Leu Ala Thr Cys Gly Lys Ala Gly Asn Phe Cys
50 55 60
Glu Cys Ser Asn Tyr Ser Thr Ser Ile Tyr Asn Ile Thr Asn Asn Cys
65 70 75 80
Ser Leu Thr Ile Phe Pro His Asn Asp Val Phe Asp Thr Thr Tyr Gln
85 90 95
Val Val Trp Asn Gln Ile Ile Asn Tyr Thr Ile Lys Leu Leu Thr Pro
100 105 110
Ala Thr Pro Pro Asn Ile Thr Tyr Asn Cys Thr Asn Phe Leu Ile Thr
115 120 125
Cys Lys Lys Asn Asn Gly Thr Asn Thr Asn Ile Tyr Leu Asn Ile Asn
130 135 140
Asp Thr Phe Val Lys Tyr Thr Asn Glu Ser Ile Leu Glu Tyr Asn Trp
145 150 155 160
Asn Asn Ser Asn Ile Asn Asn Phe Thr Ala Thr Cys Ile Ile Asn Asn
165 170 175
Thr Ile Ser Thr Ser Asn Glu Thr Thr Leu Ile Asn Cys Thr Tyr Leu
180 185 190
Thr Leu Ser Ser Asn Tyr Phe Tyr Thr Phe Phe
195 200
<210> 381
<211> 210
<212> PRT
<213> African swine fever virus
<400> 381
Met Ile Ile Ile Leu Ile Phe Leu Ile Cys Leu Lys Ile Val Leu Asn
1 5 10 15
Asn Asn Ile Ile Ile Trp His Thr Leu Asn Glu Thr Ile Phe Leu Asn
20 25 30
Asn Ser Ile Thr Phe Thr Asp Asn Leu Gly Gly Leu Phe Trp Asn Thr
35 40 45
Tyr Tyr Asn Asn Asn His Ser Ile Leu Thr Ser Cys Gly Ile Tyr Gln
50 55 60
Asn Tyr Cys Ser Cys Thr Asn Asn Tyr Ser Thr Ser Leu Tyr Asn Ile
65 70 75 80
Thr Asn Asn Cys Gly Leu Ile Ile Phe Pro Asn Asn Thr Lys Arg Phe
85 90 95
Asn Thr Thr Tyr Glu Leu Val Tyr Leu Asn Asn Ser Thr Lys Tyr Thr
100 105 110
Ile Asn Leu Leu Val Pro Val Thr Pro Pro Asn Ile Thr Tyr Asn Cys
115 120 125
Thr Thr Ser Val Ile Thr Cys Lys Lys Asn Asp Gly Thr Asn Thr Asn
130 135 140
Met Phe Leu Lys Ile Asn Asp Thr Ile Val Lys Ser Ser Asn Glu Ser
145 150 155 160
Val Phe Glu Tyr Ser Trp Asn Ser Thr Asp Leu Asn Asn Asn Phe Thr
165 170 175
Ala Ile Cys Ile Ile Asn Asn Thr Ile Asn Ser Ser Asn Asp Thr Gln
180 185 190
Thr Ile Glu Cys Pro Asn Ile Leu Leu Asn Asn Tyr Leu Asp Phe Phe
195 200 205
Gln Val
210
<210> 382
<211> 207
<212> PRT
<213> African swine fever virus
<400> 382
Met Ile Ile Ile Leu Ile Phe Leu Ile Tyr Leu Lys Leu Val Leu Asn
1 5 10 15
Asn Asn Ile Ile Ile Trp His Pro Thr Leu Asn Glu Thr Ile Phe Leu
20 25 30
Asn Val Thr Thr Ile Gly Asn Ile Ser Gly Leu Phe Trp Asn Thr Tyr
35 40 45
Tyr Asn Asn Asn Arg Ser Glu Leu Thr Lys Cys Gly Ile Tyr Asn Asn
50 55 60
Tyr Cys Ser Cys Asp Ser Leu Asn Thr Ser Leu Tyr Asn Ile Asn Asn
65 70 75 80
Cys Ser Leu Val Ile Phe Pro Asn Asn Thr Lys Ile Phe Asn Thr Ile
85 90 95
Tyr Glu Leu Ile Tyr Ser Gly Asn Gln Thr Asn Tyr Thr Ile Lys Leu
100 105 110
Leu Glu Ser Thr Thr Pro Pro Asn Ile Thr Tyr Asn Cys Thr Thr Ser
115 120 125
Val Ile Thr Cys Lys Lys Asn Asn Gly Thr Asn Thr Asn Ile Phe Leu
130 135 140
Thr Ile Asn Asn Thr Ile Val Asn Ser Thr Asn Glu Asp Val Ile Tyr
145 150 155 160
Tyr Tyr Trp Asn Arg Ser Glu Phe Asn Asn Phe Thr Ala Thr Cys Met
165 170 175
Ile Asn Asn Thr Ile Asn Ser Ser Asn Ile Ser Glu Ile Ile Asp Cys
180 185 190
Thr Asn Thr Leu Leu Leu Asn Ser Tyr Leu Asp Phe Phe Gln Val
195 200 205
<210> 383
<211> 211
<212> PRT
<213> African swine fever virus
<400> 383
Met Ile Ile Lys Val Ile Phe Leu Val Phe Phe Lys Met Val Leu Ser
1 5 10 15
Asn Ile Ile Ile Trp Ser Thr Leu Asn Asn Thr Ile Tyr Leu Asn Ile
20 25 30
Asn Tyr Ser Asp Ser Asn Leu Tyr Thr Gly Leu Phe Trp Asn Lys Tyr
35 40 45
Tyr Asn Asn Thr Arg Asn Asn Phe Thr Thr Cys Val Thr Ser Asn Ser
50 55 60
Ser Tyr Cys Thr Cys Lys Gly His Asn Thr Ser Leu Tyr Asn Ile Thr
65 70 75 80
Asn Asn Cys Ser Leu Ile Ile Phe Pro Asn Asn Thr Lys Ile Phe Asn
85 90 95
Thr Thr Tyr Glu Leu Val Tyr Leu Asn Asn Lys Ile Asn Tyr Thr Ile
100 105 110
Gln Met Val Gln Pro Val Asp Pro Pro Ile Ile Ile Tyr Asn Asp Thr
115 120 125
Asn Asn Ser Leu Ile Thr Cys Glu Lys Asn Asn Gly Thr Asn Thr Glu
130 135 140
Ile Tyr Leu Tyr Leu Asn Asp Thr Phe Ile Asn Asn Thr Asn Glu Asn
145 150 155 160
Ser Ile Lys Tyr Tyr Trp Asn Cys Ser Glu Leu Asn His Asn Ile Thr
165 170 175
Thr Thr Cys Ile Ile Asn Asn Thr Leu Asn Ser Ala Asn Thr Thr Lys
180 185 190
Val Ile Asn Cys Thr Asn Leu Leu Leu Lys Ser Asp Gln Asn Tyr Phe
195 200 205
Leu Lys Asn
210
<210> 384
<211> 205
<212> PRT
<213> African swine fever virus
<400> 384
Met Ile Ile Lys Leu Ile Phe Leu Ile Cys Phe Lys Ile Val Leu Ser
1 5 10 15
Ile Asn Tyr Trp Val Arg Tyr Asn Asp Thr Val Thr Leu Asn Ser Asn
20 25 30
Ile Asn Ser Glu Thr Glu Gly Ile Phe Trp Asn Phe Tyr Asn Asn Thr
35 40 45
Phe Asn Thr Ile Ala Thr Cys Gly Lys Lys Asn Asn Val Cys Glu Cys
50 55 60
Ser Asn Tyr Asp Lys Ser Leu Tyr Asn Ile Thr Asn Asn Cys Ser Leu
65 70 75 80
Thr Ile Phe Pro Asn Asn Thr Lys Ile Phe Asn Thr Thr Tyr Gln Leu
85 90 95
Val Tyr Ser Arg Asn Arg Ile Asn Tyr Thr Ile Asn Leu Leu Leu Pro
100 105 110
Val Thr Ser Pro Ile Ile Thr Tyr Asn Cys Thr Gln Ser Leu Ile Thr
115 120 125
Cys Glu Lys Thr Asn Gly Thr Asn Ile His Leu Phe Leu Asn Leu Asn
130 135 140
Asp Thr Ile Asn Glu Tyr Thr Asn Lys Ser Phe Leu Asn Tyr Tyr Trp
145 150 155 160
Asn Ser Ser Glu Leu Asn Asn Ile Phe Leu Ala Thr Cys Ile Ile Asn
165 170 175
Asn Thr Leu Asn Ser Ala Asn Thr Thr Lys Val Ile Asn Cys Thr Asn
180 185 190
Pro Leu Leu Lys Ser Tyr Gln Asn Tyr Phe Leu Glu Asn
195 200 205
<210> 385
<211> 203
<212> PRT
<213> African swine fever virus
<400> 385
Met Ile Ile Leu Ile Phe Leu Ile Phe Ser Asn Ile Val Leu Ser Ile
1 5 10 15
Asp Tyr Trp Val Ser Phe Asn Lys Thr Ile Ile Leu Asp Ser Asn Ile
20 25 30
Thr Asn Asp Asn Asn Asp Ile Asn Gly Val Ser Trp Asn Phe Phe Asn
35 40 45
Asn Ser Phe Asn Thr Leu Ala Thr Cys Gly Lys Ala Gly Asn Phe Cys
50 55 60
Glu Cys Ser Asn Tyr Ser Thr Ser Ile Tyr Asn Ile Thr Asn Asn Cys
65 70 75 80
Ser Leu Thr Ile Phe Pro His Asn Asp Val Phe Asp Thr Thr Tyr Gln
85 90 95
Val Val Trp Asn Gln Ile Ile Asn Tyr Thr Ile Lys Leu Leu Thr Pro
100 105 110
Ala Thr Pro Pro Asn Ile Thr Tyr Asn Cys Thr Asn Phe Leu Ile Thr
115 120 125
Cys Lys Lys Asn Asn Gly Thr Asn Thr Asn Ile Tyr Leu Asn Ile Asn
130 135 140
Asp Thr Phe Val Lys Tyr Thr Asn Glu Ser Ile Leu Glu Tyr Asn Trp
145 150 155 160
Asn Asn Ser Asn Ile Asn Asn Phe Thr Ala Thr Cys Ile Ile Asn Asn
165 170 175
Thr Ile Ser Thr Ser Asn Glu Thr Thr Leu Ile Asn Cys Thr Tyr Leu
180 185 190
Thr Leu Ser Ser Asn Tyr Phe Tyr Thr Phe Phe
195 200
<210> 386
<211> 204
<212> PRT
<213> African swine fever virus
<400> 386
Met Ile Ile Ile Leu Ile Phe Leu Ile Ile Pro Asn Ile Val Leu Ser
1 5 10 15
Ile Asp Tyr Trp Val Ser Phe Asn Lys Thr Ile Ile Leu Asp Ser Asn
20 25 30
Ile Thr Asn Asp Asn Asn Asp Ile Asn Gly Val Ser Trp Asn Phe Leu
35 40 45
Asn Asn Ser Leu Asn Thr Leu Ala Thr Cys Gly Lys Ala Gly Asn Phe
50 55 60
Cys Glu Cys Ser Asn Tyr Ser Thr Ser Leu Tyr Asn Ile Ala His Asn
65 70 75 80
Cys Ser Leu Thr Ile Phe Pro His Asn Asp Val Phe Gly Thr Pro Tyr
85 90 95
Gln Val Val Trp Asn Gln Ile Ile Asn Tyr Thr Ile Lys Leu Leu Thr
100 105 110
Pro Val Thr Pro Pro Asn Ile Thr Tyr Asn Cys Thr Asn Phe Leu Ile
115 120 125
Thr Cys Lys Lys Asn Asn Gly Thr Asn Thr Ile Ile Tyr Phe Asn Ile
130 135 140
Asn Asp Thr Asn Val Lys Tyr Thr Asn Glu Ser Ile Leu Glu Tyr Asn
145 150 155 160
Trp Asn Asn Ser Asn Phe Asn Asn Phe Thr Ala Thr Cys Ile Ile Asn
165 170 175
Asn Thr Ile Asn Ser Ser Asn Asp Thr Gln Thr Ile Asp Cys Ile Asn
180 185 190
Thr Leu Leu Ser Ser Tyr Leu Asp Phe Phe Gln Val
195 200
Claims (82)
- 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고;
하기 유전자:
다중유전자 패밀리 (MGF) 110 3L, 6L, 7L, 8L, 10L, 11L 및 12L,
MGF 360 5L, 6L, 7L, 10L, 11L, 12L, 13L, 14L, 20R, 21R 및 22R, 및
MGF 505 1R, 2R 및 6R 중 하나 이상의 기능성 버전을 포함하는,
약독화된 아프리카 돼지 열병 (ASF) 바이러스. - 제1항에 있어서, 백신접종받은 동물로부터의 감염된 동물 감별(Differentiation of Infected from Vaccinated Animals: DIVA) 돌연변이를 추가로 포함하는 약독화된 ASF 바이러스.
- 유전자 EP153R 및 EP402R의 발현 및/또는 활성이 파괴되고, DIVA 돌연변이를 포함하는 약독화된 ASF 바이러스.
- 제2항 또는 제3항에 있어서, DIVA 돌연변이가 K145R 유전자의 발현을 파괴시키는 것인 약독화된 ASF 바이러스.
- 제4항에 있어서, K145R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실된 것인 약독화된 ASF 바이러스.
- 제4항에 있어서, K145R 유전자가 중단된 것인 약독화된 ASF 바이러스.
- 제1항 내지 제6항 중 어느 한 항에 있어서, EP153R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실된 것인 약독화된 ASF 바이러스.
- 제1항 내지 제6항 중 어느 한 항에 있어서, EP153R 유전자가 중단된 것인 약독화된 ASF 바이러스.
- 제1항 내지 제8항 중 어느 한 항에 있어서, 혈구흡착을 유도하는 ASF 바이러스의 능력이, EP153R 유전자 및/또는 EP402R 유전자의 발현 및/또는 활성이 파괴되지 않은 상응하는 ASF 바이러스와 비교하여 감소된 것인, 약독화된 ASF 바이러스.
- 제1항 내지 제9항 중 어느 한 항에 있어서, EP402R 단백질의 표면 발현이 EP402R 유전자의 발현 및/또는 활성이 파괴되지 않은 상응하는 ASF 바이러스와 비교하여 감소된 것인, 약독화된 ASF 바이러스.
- 제1항 내지 제10항 중 어느 한 항에 있어서, EP402R 유전자가 EP402R 단백질에 의한 리간드 결합을 파괴시키는 하나 이상의 돌연변이를 포함하는 것인, 약독화된 ASF 바이러스.
- 제10항 또는 제11항에 있어서, EP402R 유전자가 EP402R 단백질의 리간드 결합 도메인 중의 하나 이상의 아미노산을 변이시키는 하나 이상의 돌연변이를 포함하는 것인 약독화된 ASF 바이러스.
- 제12항에 있어서, 하나 이상의 아미노산이 상이한 아미노산으로 변이된 것인 약독화된 ASF 바이러스.
- 제13항에 있어서, 상이한 아미노산으로의 변이가 EP402R 상의 결합 표면을 변경함으로써 EP402R과 그의 리간드 사이의 상호작용을 직접 억제하는 것인 약독화된 ASF 바이러스.
- 제11항 내지 제14항 중 어느 한 항에 있어서, 하나 이상의 돌연변이가 Georgia 2007/1 EP402R 단백질 (서열식별번호(SEQ ID No.) 24)의 Q96 및/또는 W99에 상응하는 EP402R 단백질 중의 위치의 아미노산을 변이시키는 것인 약독화된 ASF 바이러스.
- 제15항에 있어서, Q96에 상응하는 위치의 아미노산이 R로, 또는 R의 보존적 대체인 아미노산으로 변이되고/거나, W99에 상응하는 위치의 아미노산이 D, 또는 D의 보존적 대체인 아미노산으로 변이된 것인 약독화된 ASF 바이러스.
- 제16항에 있어서, Q96에 상응하는 위치의 아미노산이 H, K 또는 R로 변이되고/거나, W99에 상응하는 위치의 아미노산이 D, E, N 또는 Q로 변이된 것인 약독화된 ASF 바이러스.
- 제17항에 있어서, Q96에 상응하는 위치의 아미노산이 R로 변이되고/거나, W99에 상응하는 위치의 아미노산이 D로 변이된 것인 약독화된 ASF 바이러스.
- 제1항 내지 제12항 중 어느 한 항에 있어서, EP402R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실된 것인 약독화된 ASF 바이러스.
- 제1항 내지 제12항 중 어느 한 항에 있어서, EP402R 유전자가 중단된 것인 약독화된 ASF 바이러스.
- 제1항 및 제7항 내지 제20항 중 어느 한 항에 있어서, EP153R 및 EP402R 이외의 다른 모든 ASF 바이러스 유전자의 기능성 버전을 포함하는 약독화된 ASF 바이러스.
- 제1항 내지 제20항 중 어느 한 항에 있어서, EP153R, EP402R 및 K145R 이외의 다른 모든 ASF 바이러스 유전자의 기능성 버전을 포함하는 약독화된 ASF 바이러스.
- 제1항 내지 제22항 중 어느 한 항에 있어서, 약독화된 ASF 바이러스의 게놈이 유전자형 II에 상응하거나, 또는 본질적으로 그에 상응하는 것인 약독화된 ASF 바이러스.
- 제23항에 있어서, 약독화된 ASF 바이러스의 게놈이 Georgia 2007/1 균주의 것에 상응하거나, 또는 본질적으로 그에 상응하는 것인 약독화된 ASF 바이러스.
- 리간드 결합 도메인에 하나 이상의 아미노산 변이를 포함하며, 여기서 아미노산 변이가 EP402R 단백질의 리간드 결합을 파괴시키는 것인, EP402R 단백질.
- Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96 및/또는 W99에 상응하는 위치에 하나 이상의 아미노산 변이를 포함하는 EP402R 단백질.
- 제26항에 있어서, Q96에 상응하는 위치의 아미노산이 R로, 또는 R의 보존적 대체인 아미노산으로 변이되고/거나, W99에 상응하는 위치의 아미노산이 D, 또는 D의 보존적 대체인 아미노산으로 변이된 것인 EP402R 단백질.
- 제27항에 있어서, Q96에 상응하는 위치의 아미노산이 H, K 또는 R로 변이되고/거나, W99에 상응하는 위치의 아미노산이 D, E, N 또는 Q로 변이된 것인 EP402R 단백질.
- 제28항에 있어서, Q96에 상응하는 위치의 아미노산이 R로 변이되고/거나, W99에 상응하는 위치의 아미노산이 D로 변이된 것인 EP402R 단백질.
- 제25항 내지 제29항 중 어느 한 항에 있어서, 서열식별번호 21 내지 30 또는 서열식별번호 242 내지 246 중 임의의 것과 적어도 70%의 서열 동일성을 갖는 아미노산 서열을 포함하는 EP402R 단백질.
- 제30항에 있어서, 서열식별번호 31, 32, 33 또는 379 중 임의의 것의 아미노산 서열을 포함하는 EP402R 단백질.
- 제25항 내지 제31항 중 어느 한 항의 EP402R 단백질을 코딩하는 폴리뉴클레오티드.
- 제32항에 있어서, 서열식별번호 229 내지 241 중 임의의 것과 적어도 70%의 서열 동일성을 갖는 서열을 포함하는 폴리뉴클레오티드.
- 제32항 또는 제33항의 폴리뉴클레오티드를 포함하는 벡터.
- 제25항 내지 제31항 중 어느 한 항의 EP402R 단백질을 포함하는 ASF 바이러스.
- 제32항 또는 제33항의 폴리뉴클레오티드를 포함하는 ASF 바이러스.
- 제35항 또는 제36항에 있어서, 혈구흡착을 유도하는 ASF 바이러스의 능력이, 제25항 내지 제31항 중 어느 한 항의 EP402R 단백질, 또는 제32항 또는 제33항의 폴리뉴클레오티드를 포함하지 않는 상응하는 ASF 바이러스와 비교하여 감소된 것인 ASF 바이러스.
- 제35항 내지 제37항 중 어느 한 항에 있어서, 약독화된 것인 ASF 바이러스.
- 제35항 내지 제38항 중 어느 한 항에 있어서, DIVA 돌연변이를 추가로 포함하는 ASF 바이러스.
- 제39항에 있어서, DIVA 돌연변이가 K145R 유전자의 발현을 파괴시키는 것인 ASF 바이러스.
- 제40항에 있어서, K145R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실된 것인 ASF 바이러스.
- 제40항에 있어서, K145R 유전자가 중단된 것인 ASF 바이러스.
- 제35항 내지 제42항 중 어느 한 항에 있어서, EP153R 유전자의 발현 및/또는 활성이 파괴된 것인 ASF 바이러스.
- 제43항에 있어서, EP153R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실된 것인 ASF 바이러스.
- 제43항에 있어서, EP153R 유전자가 중단된 것인 ASF 바이러스.
- 제35항 내지 제45항 중 어느 한 항에 있어서, ASF 바이러스 게놈이 유전자형 II에 상응하거나, 또는 본질적으로 그에 상응하는 것인 ASF 바이러스.
- 제46항에 있어서, ASF 바이러스 게놈이 Georgia 2007/1 균주의 것에 상응하거나, 또는 본질적으로 그에 상응하는 것인 ASF 바이러스.
- 제1항 내지 제24항 및 제35항 내지 제47항 중 어느 한 항에 있어서, 대상체에서 질환을 치료 및/또는 예방하는 데 사용하기 위한 ASF 바이러스.
- 대상체에서의 질환 치료 및/또는 예방용 의약의 제조를 위한 제1항 내지 제24항 및 제35항 내지 제47항 중 어느 한 항의 ASF 바이러스의 용도.
- 제1항 내지 제24항 및 제35항 내지 제47항 중 어느 한 항의 ASF 바이러스를 포함하는 제약 조성물.
- 제50항에 있어서, 대상체에서 질환을 치료 및/또는 예방하는 데 사용하기 위한 제약 조성물.
- 제48항, 제49항 및 제51항 중 어느 한 항에 있어서, 질환이 아프리카 돼지 열병인, ASF 바이러스, ASF 바이러스의 용도 또는 제약 조성물.
- 제1항 내지 제24항 및 제35항 내지 제47항 중 어느 한 항의 ASF 바이러스를 포함하는 백신.
- 제53항에 있어서, 대상체에서 아프리카 돼지 열병을 치료 및/또는 예방하는 데 사용하기 위한 백신.
- 제54항에 있어서, 아프리카 돼지 열병이 백신의 ASF 바이러스와 상이한 유전자형의 ASF 바이러스에 유발되는 것인 백신.
- 대상체에게 유효량의, 제50항에 따른 제약 조성물, 또는 제53항에 따른 백신을 투여하는 단계를 포함하는, 대상체에서 아프리카 돼지 열병을 치료 및/또는 예방하는 방법.
- 제48항, 제49항, 제51항, 제52항 및 제54항 내지 제56항 중 어느 한 항에 있어서, 대상체가 가축용 돼지인, ASF 바이러스, ASF 바이러스의 용도, 제약 조성물, 백신 또는 방법.
- 제54항 내지 제57항 중 어느 한 항에 있어서, 백신이 프라임-부스트 요법에 따라 투여되는 것인, 백신 또는 방법.
- EP402R 단백질의 리간드 결합 도메인 중의 하나 이상의 아미노산을 변이시키는 단계를 포함하고, 여기서, 아미노산 변이가 EP402R 단백질의 리간드 결합을 파괴시키는 것인, 제35항 내지 제47항 중 어느 한 항의 ASF 바이러스를 제조하는 방법.
- Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96 및/또는 W99에 상응하는 위치의 EP402R 단백질 중의 하나 이상의 아미노산을 변이시키는 단계를 포함하는, 제35항 내지 제47항 중 어느 한 항의 ASF 바이러스를 제조하는 방법.
- EP402R 단백질의 리간드 결합 도메인 중의 하나 이상의 아미노산 변이를 변이시키는 단계를 포함하고, 여기서, 아미노산 변이가 EP402R 단백질의 리간드 결합을 파괴시키는 것인, 혈구흡착을 유도하는 ASF 바이러스의 능력을 감소시키는 방법.
- Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96 및/또는 W99에 상응하는 위치의 EP402R 단백질 중의 아미노산을 변이시키는 단계를 포함하는, 혈구흡착을 유도하는 ASF 바이러스의 능력을 감소시키는 방법.
- 제59항 내지 제62항 중 어느 한 항에 있어서, EP153R 유전자의 발현 및/또는 활성을 파괴시키는 단계를 추가로 포함하는 방법.
- EP153R 및 EP402R 유전자의 발현 및/또는 활성을 파괴시키는 단계를 포함하는, ASF 바이러스를 약독화시키는 방법.
- 제64항에 있어서, 혈구흡착을 매개하는 EP153R 유전자 및/또는 EP402R 유전자의 능력을 파괴시키는 단계를 포함하는 방법.
- 제59항 내지 제65항 중 어느 한 항에 있어서, DIVA 돌연변이를 ASF 바이러스 내로 도입하는 단계를 추가로 포함하는 방법.
- 제66항에 있어서, DIVA 돌연변이가 K145R 유전자의 발현을 파괴시키는 것인 방법.
- 제67항에 있어서, K145R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실된 것인 방법.
- 제67항에 있어서, K145R 유전자가 중단된 것인 방법.
- 제63항 내지 제69항 중 어느 한 항에 있어서, EP153R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실된 것인 방법.
- 제63항 내지 제69항 중 어느 한 항에 있어서, EP153R 유전자가 중단된 것인 방법.
- 제64항 내지 제71항 중 어느 한 항에 있어서, EP402R 유전자가 적어도 부분적으로 결실, 바람직하게, 완전히 결실된 것인 방법.
- 제64항 내지 제71항 중 어느 한 항에 있어서, EP402R 유전자가 중단된 것인 방법.
- 제64항 내지 제73항 중 어느 한 항에 있어서, 하나 이상의 돌연변이를 포함하지 않는 상응하는 ASF 바이러스와 비교하여 감소된 EP402R 단백질의 표면 발현을 감소시키는 하나 이상의 돌연변이를 EP402R 유전자에 도입하는 단계를 포함하는 방법.
- 제64항 내지 제74항 중 어느 한 항에 있어서, EP402R 단백질에 의한 리간드 결합을 파괴시키는 하나 이상의 돌연변이를 EP402R 유전자에 도입하는 단계를 포함하는 방법.
- 제74항 또는 제75항에 있어서, EP402R 단백질의 리간드 결합 도메인 중의 하나 이상의 아미노산을 변이시키는 하나 이상의 돌연변이를 EP402R 유전자에 도입하는 단계를 포함하는 방법.
- 제76항에 있어서, 하나 이상의 아미노산을 상이한 아미노산으로 변이시키는 것인 방법.
- 제77항에 있어서, 상이한 아미노산으로의 변이가 EP402R 상의 결합 표면을 변경함으로써 EP402R과 그의 리간드 사이의 상호작용을 직접 억제하는 것인 방법.
- 제75항 내지 제78항 중 어느 한 항에 있어서, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96 및/또는 W99에 상응하는 위치의 EP402R 단백질 중의 아미노산을 변이시키는 단계를 포함하는 방법.
- 제59항 내지 제79항 중 어느 한 항에 있어서, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 Q96에 상응하는 위치의 EP402R 단백질 중의 아미노산을 R로, 또는 R의 보존적 대체인 아미노산으로 변이시키고/거나, Georgia 2007/1 EP402R 단백질 (서열식별번호 24)의 W99에 상응하는 위치의 아미노산을 D로, 또는 D의 보존적 대체인 아미노산으로 변이시키는 단계를 포함하는 방법.
- 제80항에 있어서, Q96에 상응하는 위치의 아미노산을 H, K 또는 R로 변이시키고/거나, W99에 상응하는 위치의 아미노산을 D, E, N 또는 Q로 변이시키는 것인 방법.
- 제81항에 있어서, Q96에 상응하는 위치의 아미노산을 R로 변이시키고/거나, W99에 상응하는 위치의 아미노산을 D로 변이시키는 것인 방법.
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GBGB2003292.6A GB202003292D0 (en) | 2020-03-06 | 2020-03-06 | Vaccine |
GBGB2003289.2A GB202003289D0 (en) | 2020-03-06 | 2020-03-06 | Vaccine |
GB2003289.2 | 2020-03-06 | ||
GB2003292.6 | 2020-03-06 | ||
GB2005878.0 | 2020-04-22 | ||
GBGB2005878.0A GB202005878D0 (en) | 2020-04-22 | 2020-04-22 | Vaccine |
GBGB2005880.6A GB202005880D0 (en) | 2020-04-22 | 2020-04-22 | Vaccine |
GB2005880.6 | 2020-04-22 | ||
GB2013541.4 | 2020-08-28 | ||
GBGB2013541.4A GB202013541D0 (en) | 2020-08-28 | 2020-08-28 | Vaccine |
PCT/GB2021/050562 WO2021176236A1 (en) | 2020-03-06 | 2021-03-05 | Vaccine against african swine fever virus infection |
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KR1020227034852A KR20230013016A (ko) | 2020-03-06 | 2021-03-05 | 아프리카 돼지 열병 바이러스 감염에 대한 백신 |
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WO2024057048A1 (en) * | 2022-09-12 | 2024-03-21 | Consejo Superior De Investigaciones Científicas | Attenuated african swine fever virus and use thereof in vaccine compositions |
WO2024110451A1 (en) * | 2022-11-22 | 2024-05-30 | Intervet International B.V. | Attenuated african swine fever virus and use thereof in vaccine compositions |
WO2024110453A1 (en) * | 2022-11-22 | 2024-05-30 | Gold Standard Diagnostics Madrid, S.A. | Method for differentiating asfv infected from asfv vaccinated animals |
CN117224669B (zh) * | 2023-07-31 | 2024-07-30 | 中国农业科学院兰州兽医研究所 | 非洲猪瘟病毒mgf360-21r蛋白作为免疫诱导剂或者佐剂的应用 |
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CN110551695A (zh) * | 2019-08-14 | 2019-12-10 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 非洲猪瘟病毒四基因缺失弱毒株及其应用 |
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AU2021229654A1 (en) | 2022-11-03 |
CN116133680A (zh) | 2023-05-16 |
EP4114454A1 (en) | 2023-01-11 |
JP2023516713A (ja) | 2023-04-20 |
BR112022016891A2 (pt) | 2023-01-24 |
MX2022010373A (es) | 2023-01-19 |
CN115397463A (zh) | 2022-11-25 |
WO2021176236A1 (en) | 2021-09-10 |
US20230117978A1 (en) | 2023-04-20 |
CA3170058A1 (en) | 2021-09-10 |
WO2021176235A1 (en) | 2021-09-10 |
BR112022016893A8 (pt) | 2023-02-28 |
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