CN1152899C - 线型嵌段聚合物和它的生产方法及其用途 - Google Patents

线型嵌段聚合物和它的生产方法及其用途 Download PDF

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Publication number
CN1152899C
CN1152899C CNB961999462A CN96199946A CN1152899C CN 1152899 C CN1152899 C CN 1152899C CN B961999462 A CNB961999462 A CN B961999462A CN 96199946 A CN96199946 A CN 96199946A CN 1152899 C CN1152899 C CN 1152899C
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CN
China
Prior art keywords
block polymer
linear block
groups
implant
molecular weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB961999462A
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English (en)
Chinese (zh)
Other versions
CN1214057A (zh
Inventor
P
P·弗罗丁
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ATEM POLYRAND AB
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ATEM POLYRAND AB
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Publication of CN1214057A publication Critical patent/CN1214057A/zh
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Publication of CN1152899C publication Critical patent/CN1152899C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/67—Unsaturated compounds having active hydrogen
    • C08G18/675—Low-molecular-weight compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/30—Low-molecular-weight compounds
    • C08G18/32—Polyhydroxy compounds; Polyamines; Hydroxyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4236—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups
    • C08G18/4238—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups derived from dicarboxylic acids and dialcohols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269—Lactones
    • C08G18/4277—Caprolactone and/or substituted caprolactone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)
CNB961999462A 1995-12-15 1996-11-25 线型嵌段聚合物和它的生产方法及其用途 Expired - Lifetime CN1152899C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9504495A SE505703C2 (sv) 1995-12-15 1995-12-15 Linjär blockpolymer innefattande urea- och uretangrupper, förfarande för framställning av linjära blockpolymerer samt användning av blockpolymererna som implantat
SE95044954 1995-12-15

Publications (2)

Publication Number Publication Date
CN1214057A CN1214057A (zh) 1999-04-14
CN1152899C true CN1152899C (zh) 2004-06-09

Family

ID=20400606

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB961999462A Expired - Lifetime CN1152899C (zh) 1995-12-15 1996-11-25 线型嵌段聚合物和它的生产方法及其用途

Country Status (26)

Country Link
US (1) US6210441B1 (enExample)
EP (1) EP0866816B1 (enExample)
JP (1) JP4059524B2 (enExample)
KR (1) KR20000064383A (enExample)
CN (1) CN1152899C (enExample)
AT (1) ATE201704T1 (enExample)
AU (1) AU709440B2 (enExample)
BR (1) BR9612032A (enExample)
CA (1) CA2240061A1 (enExample)
CZ (1) CZ179398A3 (enExample)
DE (1) DE69613144T2 (enExample)
DK (1) DK0866816T3 (enExample)
ES (1) ES2159769T3 (enExample)
GR (1) GR3036469T3 (enExample)
HU (1) HUP9901201A3 (enExample)
IL (1) IL124884A (enExample)
NO (1) NO982703L (enExample)
NZ (1) NZ324479A (enExample)
PL (1) PL327246A1 (enExample)
PT (1) PT866816E (enExample)
RU (1) RU2189993C2 (enExample)
SE (1) SE505703C2 (enExample)
SI (1) SI0866816T1 (enExample)
SK (1) SK79798A3 (enExample)
TR (1) TR199801091T2 (enExample)
WO (1) WO1997022643A1 (enExample)

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SE510868C2 (sv) * 1997-11-03 1999-07-05 Artimplant Dev Artdev Ab Formkroppar för användning som implantat i humanmedicin samt förfarande för framställning av sådana formkroppar
SE513491C2 (sv) * 1998-12-15 2000-09-18 Artimplant Dev Artdev Ab Implantat för insättning i människor eller djur innefattande böjliga trådformiga element
SE514064C2 (sv) 1999-02-02 2000-12-18 Artimplant Dev Artdev Ab Film för medicinsk användning bestående av linjära blockpolymerer av polyuretaner samt förfarande för framställning av en sådan film
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
SE0101523L (sv) * 2000-12-29 2002-06-30 Artimplant Ab Linjär polymer
AR032052A1 (es) * 2000-12-29 2003-10-22 Artimplant Ab Polimero lineal de bloques, procedimiento para su preparacion, su uso, implantes, material para relleno, composiciones farmaceuticas y material polimerico poroso que comprenden dicho polimero lineal de bloques
SE526106C2 (sv) * 2002-06-20 2005-07-05 Artimplant Ab Linjär blockpolymer samt fiber, film, poröst material och implantat innefattande polymeren
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
EP1592728A2 (en) * 2003-01-16 2005-11-09 Carnegie-Mellon University Biodegradable polyurethanes and use thereof
US20070160622A1 (en) * 2005-12-07 2007-07-12 Medivas, Llc Method for assembling a polymer-biologic delivery composition
US8791073B2 (en) * 2004-05-14 2014-07-29 William Marsh Rice University Peptide-modified polyurethane compositions and associated methods
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US7728097B2 (en) * 2005-01-10 2010-06-01 Ethicon, Inc. Method of making a diisocyanate terminated macromer
US20070167617A1 (en) * 2006-01-17 2007-07-19 Fitz Benjamin D Method of making a diisocyanate terminated macromer
US20060153796A1 (en) * 2005-01-10 2006-07-13 Fitz Benjamin D Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US8470954B2 (en) 2005-01-10 2013-06-25 Ethicon, Inc. Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US7968668B2 (en) 2005-01-10 2011-06-28 Ethicon Inc. Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
EP1700872A3 (en) * 2005-03-10 2008-07-23 Radi Medical Systems Ab Polyureaurethane material and method of producing a polyureaurethane material
DE102005033101A1 (de) * 2005-07-15 2007-01-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Resorbierbare Polyetherester und ihre Verwendung zur Herstellung von medizinischen Implantaten
US8652504B2 (en) * 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
EP1926780B1 (en) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
US20070100324A1 (en) * 2005-10-17 2007-05-03 Coaptus Medical Corporation Systems and methods for applying vacuum to a patient, including via a disposable liquid collection unit
EP1945682A2 (en) * 2005-10-21 2008-07-23 Medivas, LLC Poly(ester urea) polymers and methods of use
US20070292476A1 (en) * 2006-05-02 2007-12-20 Medivas, Llc Delivery of ophthalmologic agents to the exterior or interior of the eye
JP5196498B2 (ja) * 2006-05-09 2013-05-15 メディバス エルエルシー 生分解性水溶性ポリマー
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
EP1985319B1 (en) * 2007-04-23 2012-06-13 Jointsphere B.V. Device for cartilage repair
WO2009015143A1 (en) * 2007-07-24 2009-01-29 Medivas, Llc Biodegradable cationic polymer gene transfer compositions and methods of use
US8071663B2 (en) * 2008-02-29 2011-12-06 Ethicon, Inc. Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant
US8324292B2 (en) * 2008-02-29 2012-12-04 Ethicon, Inc. Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant
WO2010019716A1 (en) * 2008-08-13 2010-02-18 Medivas, Llc Aabb-poly(depsipeptide) biodegradable polymers and methods of use
US8962784B2 (en) 2008-12-19 2015-02-24 Ethicon, Inc. Isocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant
US9050176B2 (en) 2009-04-03 2015-06-09 Biomerix Corporation At least partially resorbable reticulated elastomeric matrix elements and methods of making same
WO2010114633A1 (en) 2009-04-03 2010-10-07 Biomerix Corporation At least partially resorbable reticulated elastomeric matrix elements and methods of making same
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
CA2839526A1 (en) 2011-06-23 2012-12-27 Dsm Ip Assets B.V. Micro- or nanoparticles comprising a biodegradable polyesteramide copolymer for use in the delivery of bioactive agents
TWI641396B (zh) * 2011-09-23 2018-11-21 Bvw控股公司 醫療共聚物
EP3233067B1 (en) 2014-12-18 2019-11-06 DSM IP Assets B.V. Drug delivery system for delivery of acid sensitive drugs
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CN112011049A (zh) * 2019-05-30 2020-12-01 中国科学院化学研究所 一种热塑性聚脲弹性体及其制备方法

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Also Published As

Publication number Publication date
SE505703C2 (sv) 1997-09-29
DE69613144D1 (de) 2001-07-05
EP0866816B1 (en) 2001-05-30
DK0866816T3 (da) 2001-09-10
BR9612032A (pt) 1999-12-28
PT866816E (pt) 2001-10-31
NZ324479A (en) 1999-05-28
SI0866816T1 (enExample) 2001-10-31
CA2240061A1 (en) 1997-06-26
JP4059524B2 (ja) 2008-03-12
WO1997022643A1 (en) 1997-06-26
EP0866816A1 (en) 1998-09-30
DE69613144T2 (de) 2001-11-29
NO982703D0 (no) 1998-06-11
SE9504495L (sv) 1997-06-16
ES2159769T3 (es) 2001-10-16
HUP9901201A3 (en) 2000-04-28
CN1214057A (zh) 1999-04-14
RU2189993C2 (ru) 2002-09-27
SK79798A3 (en) 1999-03-12
IL124884A0 (en) 1999-01-26
CZ179398A3 (cs) 1998-11-11
HUP9901201A2 (hu) 1999-07-28
AU709440B2 (en) 1999-08-26
NO982703L (no) 1998-07-14
IL124884A (en) 2002-03-10
JP2000502142A (ja) 2000-02-22
GR3036469T3 (en) 2001-11-30
SE9504495D0 (sv) 1995-12-15
KR20000064383A (ko) 2000-11-06
TR199801091T2 (xx) 2001-12-21
US6210441B1 (en) 2001-04-03
AU1154797A (en) 1997-07-14
PL327246A1 (en) 1998-12-07
ATE201704T1 (de) 2001-06-15

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