CN115279458A - 组合物和敏感性说明 - Google Patents

组合物和敏感性说明 Download PDF

Info

Publication number
CN115279458A
CN115279458A CN202180020463.2A CN202180020463A CN115279458A CN 115279458 A CN115279458 A CN 115279458A CN 202180020463 A CN202180020463 A CN 202180020463A CN 115279458 A CN115279458 A CN 115279458A
Authority
CN
China
Prior art keywords
light
exposure
composition
ses
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180020463.2A
Other languages
English (en)
Chinese (zh)
Inventor
亚伊尔·阿尔斯特
查尔斯·博斯沃斯
希拉·艾普斯坦-巴拉什
奥默·拉法尔里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mg Therapeutics Ltd
Original Assignee
Mg Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mg Therapeutics Ltd filed Critical Mg Therapeutics Ltd
Publication of CN115279458A publication Critical patent/CN115279458A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202180020463.2A 2020-01-10 2021-01-07 组合物和敏感性说明 Pending CN115279458A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062959738P 2020-01-10 2020-01-10
US62/959,738 2020-01-10
PCT/IB2021/000005 WO2021140417A2 (en) 2020-01-10 2021-01-07 Instructions for composition and sensitivity

Publications (1)

Publication Number Publication Date
CN115279458A true CN115279458A (zh) 2022-11-01

Family

ID=76787770

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180020463.2A Pending CN115279458A (zh) 2020-01-10 2021-01-07 组合物和敏感性说明

Country Status (6)

Country Link
US (3) US11517586B2 (enExample)
EP (1) EP4087655A4 (enExample)
JP (2) JP7796016B2 (enExample)
CN (1) CN115279458A (enExample)
CA (1) CA3166357A1 (enExample)
WO (1) WO2021140417A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114980957A (zh) * 2019-11-04 2022-08-30 阿祖拉眼科有限公司 针对眼内或眼周病症的计量剂量
EP4087655A4 (en) 2020-01-10 2024-02-21 Azura Ophthalmics Ltd INSTRUCTIONS FOR COMPOSITION AND SENSITIVITY
WO2025012701A2 (en) * 2023-07-07 2025-01-16 Azura Ophthalmics Ltd. Administration of keratolytics to ocular and periocular surfaces

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107105669A (zh) * 2014-10-19 2017-08-29 姆吉医疗有限公司 用于治疗睑板腺功能障碍的组合物和方法
US20180303906A1 (en) * 2017-04-19 2018-10-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Il-24 to treat inflammatory diseases
CN109310665A (zh) * 2016-04-14 2019-02-05 阿祖拉眼科有限公司 用于治疗睑板腺功能障碍的二硫化硒组合物
CN114980957A (zh) * 2019-11-04 2022-08-30 阿祖拉眼科有限公司 针对眼内或眼周病症的计量剂量

Family Cites Families (228)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2209192A (en) 1939-08-12 1940-07-23 Michael E Demsey Medication appliance
US3236730A (en) * 1962-01-04 1966-02-22 Miles Lab Blepharitis composition comprising antiseptic, quaternary ammonium compound, keratolytic agent and a chelating compound
US3279466A (en) 1963-06-19 1966-10-18 Dwain E Mings Eye drop aid for administering ophthalmic solution without excessive head tilting
US3439674A (en) 1966-02-18 1969-04-22 Jhon Lelicoff Liquid eyewash dispensing device including eyelid engaging means
US3934590A (en) 1974-11-21 1976-01-27 Campagna Gary J Ocular positioning droplet dispensing device
US4085750A (en) 1975-03-10 1978-04-25 Bosshold Barry L Eyedropper bottle attachment
US4002168A (en) 1975-04-24 1977-01-11 Tor Petterson Method of, and dispenser for introducing an opthalmic product into the occular cavity
CH630801A5 (en) 1978-04-24 1982-07-15 Barry L Bosshold Auxiliary device on a compressible eye dropper for easier dispensing of drops
NL7804368A (en) 1978-04-24 1979-10-26 Bosshold Barry L Eye drop bottle attachment with flexible arms - which force the eyelids apart and support the bottle during use
US4512977A (en) 1979-10-18 1985-04-23 Lundy Research Laboratories, Inc. Therapeutic selenium compositions and the use thereof
US4531944A (en) 1983-04-28 1985-07-30 Bechtle Samuel J Eye drop application aid
US4543096A (en) 1983-08-05 1985-09-24 Thomas Keene Eyedrop dispenser with eyelid opening means
ES283484Y (es) 1983-11-29 1986-01-01 Loran B. Morgan Un aparato para suministrar en flujo continuo una solucion medicamentosa liquida a por lo menos la parte corneal del globo ocular de un paciente.
US4605398A (en) 1984-04-20 1986-08-12 Herrick Robert S Dispensing device for container having fluid to be controllably dispensed into an eye
US4909801A (en) 1986-06-16 1990-03-20 Acorn Laboratories, Inc. Eyedrop dispenser having a bumper
US4733802A (en) 1986-11-05 1988-03-29 Sheldon Gerald M Eye drop dispensing system
US4838851A (en) 1986-11-26 1989-06-13 Shabo Alan L Applicator and package therefor
US5602130A (en) 1987-03-20 1997-02-11 Allergan Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
US4981479A (en) 1987-11-06 1991-01-01 Py Daniel C Ocular treatment apparatus
US5133702A (en) 1987-11-06 1992-07-28 O.P.T.I.C. Ocular treatment apparatus
US4946452A (en) 1987-11-06 1990-08-07 Py Daniel C Ocular treatment apparatus
US4792334A (en) 1987-11-06 1988-12-20 Py Daniel C Occular treatment apparatus
US4960407A (en) 1987-12-08 1990-10-02 Cope Samuel M Disposable eye drop dispenser instrument for post-surgical and general use
US4834727A (en) 1987-12-08 1989-05-30 Cope Samuel M Eye dropper bottle attachment for post-surgical and general use
US5037406A (en) 1988-06-20 1991-08-06 Smith William L Eyedrop applicator attachment
US5007905A (en) 1990-02-20 1991-04-16 Bauer George C Eye drop applicator
US5059188A (en) 1990-03-28 1991-10-22 Goddard Larry C Eye dropper attachment
US5221027A (en) 1991-02-20 1993-06-22 Merck & Co., Inc. Fluid dispenser tip with recessed dispensing nozzle
IT1258781B (it) 1992-01-16 1996-02-29 Zambon Spa Composizione farmaceutica oftalmica contenente n-acetilcisteina e polivinilalcol
US5401259A (en) 1992-04-06 1995-03-28 Py Daniel C Cartridge for applying medicament to an eye
US5267986A (en) 1992-04-06 1993-12-07 Self-Instill & Co., Inc. Cartridge for applying medicament to an eye from a dispenser
WO1993020785A1 (en) 1992-04-20 1993-10-28 Basilice Vincent P Improvements in dispensing eye drops
AU670298B2 (en) 1992-05-20 1996-07-11 Karen E. Burke Renewal of extrinsic aging of the skin by transdermal application of selenoamino acids
US5387202A (en) 1992-07-20 1995-02-07 Aaron Medical Industries Eye drop dispensing device
US5645827A (en) 1992-09-30 1997-07-08 Union Carbide Chemicals & Plastics Technology Corporation Muco-adhesive polymers
CN1050748C (zh) 1993-04-22 2000-03-29 孟丽君 表面麻醉涂膜剂的制备方法
US5382243A (en) 1993-09-14 1995-01-17 Mulholland; Adrian Apparatus with indicator for administration of eye medication
JP2891883B2 (ja) 1993-11-05 1999-05-17 学校法人近畿大学 抗白内障医薬組成物
US5578019A (en) 1995-06-07 1996-11-26 Feldman; Edward L. Eye drop applicator
US5922349A (en) 1995-09-28 1999-07-13 Schering Aktiengesellschaft Hormone replacement therapy method and hormone dispenser
WO1997020578A1 (en) 1995-12-04 1997-06-12 University Of Miami Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance
US5965606A (en) 1995-12-29 1999-10-12 Allergan Sales, Inc. Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity
US5810794A (en) 1996-11-21 1998-09-22 Peplinski; Lee S. Eye drop dispensing device
FR2756493B1 (fr) 1996-12-02 2001-04-13 Delab Dispositif d'administration locale de formulations solides ou semi-solides
US6530908B1 (en) 1996-12-20 2003-03-11 Thomas M. Sherman Eye dropper positioning device
JP3496114B2 (ja) 1997-08-29 2004-02-09 参天製薬株式会社 角膜新生血管増殖抑制剤
US6033384A (en) 1997-12-18 2000-03-07 Py; Daniel One-way actuation release mechanism for a system for applying medicament
EP0930072A1 (en) 1998-01-13 1999-07-21 Kartar Dr. Lalvani Vitamin and mineral containing compositions for the treatment of dry eye
JP3407654B2 (ja) 1998-04-14 2003-05-19 ライオン株式会社 眼科用組成物
US6010488A (en) 1998-09-28 2000-01-04 Deas; Gerald W. Lower eyelid retractor and method for applying medication to the eye
US6090086A (en) 1998-11-03 2000-07-18 Bolden; Amos Eye drop applicator with adjustable guide arm and improved closure system
US6011067A (en) 1999-06-11 2000-01-04 Thione International, Inc. Antioxidant composition for the treatment of psoriasis and related diseases
CA2402384A1 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors
US6348508B1 (en) 2000-04-04 2002-02-19 Bausch & Lomb Incorporated Method for treating dry eye
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
AUPQ877300A0 (en) 2000-07-13 2000-08-03 Johnson & Johnson Pacific Pty Limited Topical treatment of skin
US6495158B1 (en) 2001-01-19 2002-12-17 Lec Tec Corporation Acne patch
US20020127256A1 (en) 2001-03-01 2002-09-12 Howard Murad Compositions and methods for treating dermatological disorders
US6371945B1 (en) 2001-03-27 2002-04-16 Thomas Sherman Eye dropper positioning device
FR2832637B1 (fr) 2001-06-07 2004-07-30 Lefaix Marie Therese Droy Utilisation d'un antioxydant pour la fabrication d'un medicament destine au traitement des affections oculaires de surface
CA2463975A1 (en) 2001-10-26 2003-05-01 Maria Emilia Di Francesco Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
US6508793B1 (en) 2001-11-05 2003-01-21 Valley Design, Inc. Invertible eye drop dispenser device
FR2833268B1 (fr) 2001-12-12 2005-07-08 Fabre Pierre Dermo Cosmetique Nouvelle association contenant un poloxamer et de l'acide chondroitine sulfurique et/ou une glycoproteine et son utilisation
KR100564386B1 (ko) 2002-05-13 2006-03-27 주식회사 마이코플러스 4-하이드록시-5-메톡시-4-[2-메틸-3-(3-메틸-2-부테닐)-2-옥시란닐]-1-옥사스피로[2,5]옥탄-6-온을 함유한 지루치료용 약제학적 조성물
US20030224028A1 (en) 2002-05-13 2003-12-04 Societe L'oreal S.A. Metal complexes for promoting skin desquamation and/or stimulating epidermal renewal
US8420699B1 (en) 2002-06-19 2013-04-16 Irvine L. Dubow Composition and methods of treatment using deionized and ozonated solution
CN101897662B (zh) 2002-07-23 2013-05-22 诺瓦提斯公司 包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物
EP2272340B1 (en) 2002-08-19 2018-03-14 Ira Sanders Botulinum toxin
US20040171561A1 (en) 2002-09-03 2004-09-02 Popp Karl F. Topical formulations for treatment of rosacea
US7795203B2 (en) 2002-09-30 2010-09-14 Babizhayev Mark A Method for topical treatment of eye disease and composition and device for said treatment
US20070292355A1 (en) 2002-10-25 2007-12-20 Foamix Ltd. Anti-infection augmentation foamable compositions and kit and uses thereof
US20060188471A1 (en) 2002-10-31 2006-08-24 Podolsky Daniel K Methods of treating epithelial lesions
GB0225795D0 (en) 2002-11-05 2002-12-11 Guillon Michael Wipes
US20070269537A1 (en) 2003-02-10 2007-11-22 Bioderm Research Skin Condition Improvement Including Acne, Rosacea, and Topical Wounds by Artemisia Annua Extract via Iron Siderophore Trojan Horse Delivery System
US7235065B1 (en) 2003-04-24 2007-06-26 Sorensen Peter H Adjustable holder for an eyedropper
US20040220167A1 (en) * 2003-05-02 2004-11-04 Nasrollah Samiy Methods of treating neuralgic pain
US20050065091A1 (en) 2003-09-18 2005-03-24 Gholam Peyman Stabilized ocular solutions
GB0322448D0 (en) 2003-09-25 2003-10-29 Lamellar Therapeutics Ltd Using lamellar bodies to modify linear biological macro molecules
US20050101921A1 (en) 2003-11-07 2005-05-12 Sherman Thomas M. Eyedropper positioning device
JP2007517893A (ja) 2004-01-10 2007-07-05 バイオリピッド インコーポレイテッド 脂質組成物及び該脂質組成物の使用方法
AU2005213895A1 (en) 2004-02-19 2005-09-01 Chemaphor Inc. Topical formulations for the treatment of skin conditions
GB0404693D0 (en) 2004-03-02 2004-04-07 Univ London Pharmaceutical preparations for the treatment of ocular surface and other disorders
US20050197614A1 (en) 2004-03-04 2005-09-08 Wilson Pritchard Occlusive biomedical devices, punctum plugs, and methods of use thereof
US20050202097A1 (en) 2004-03-12 2005-09-15 Melbj Holdings, Llc, Florida Lubricant for the ocular surface
US8455016B2 (en) 2004-03-12 2013-06-04 Melbj Holdings, Llc Treatment for meibomian gland dysfunction or obstruction
US7572766B2 (en) 2004-06-16 2009-08-11 Affinergy, Inc. IFBMs to promote the specific attachment of target analytes to the surface of orthopedic implants
WO2006014484A2 (en) * 2004-07-02 2006-02-09 Surmodics, Inc. Methods and devices for the treatment of ocular conditions
EP1621191A1 (en) 2004-07-29 2006-02-01 Werner Bollag Treatment of inflammatory diseases by RXR Antagonists
WO2006022762A1 (en) 2004-08-02 2006-03-02 Muhammed Majeed Compositions and methods for the management of hyperproliferative dermatological conditions
US8206362B1 (en) 2004-10-01 2012-06-26 E-Z Eye Med, Inc. Device for administering eye drops
US20060081726A1 (en) 2004-10-14 2006-04-20 Gerondale Scott J Controlled drop dispensing tips for bottles
US20060129113A1 (en) 2004-12-09 2006-06-15 James Merrick Eye drop applicator
US7325708B2 (en) 2005-01-14 2008-02-05 Rory Barber Ocular positioning droplet dispensing device with a recessed dispensing orifice
US7776915B2 (en) 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use
US20090214676A1 (en) 2005-04-30 2009-08-27 Tissuetech, Inc. Method for treating ocular demodex
AU2006260184B2 (en) 2005-06-22 2011-05-12 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Prophylactic or therapeutic agent for corneal/conjunctival disease
US7981146B2 (en) 2006-05-15 2011-07-19 Tearscience Inc. Inner eyelid treatment for treating meibomian gland dysfunction
US8083787B2 (en) 2005-07-18 2011-12-27 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction
WO2013003594A2 (en) 2011-06-28 2013-01-03 Tearscience, Inc. Methods and systems for treating meibomian gland dysfunction using radio-frequency energy
US7981095B2 (en) 2005-07-18 2011-07-19 Tearscience, Inc. Methods for treating meibomian gland dysfunction employing fluid jet
WO2007070463A2 (en) 2005-12-12 2007-06-21 Riolan Technologies, Inc. Compositions, methods and kits for removing debris from an ocular area
WO2007113830A2 (en) 2006-04-04 2007-10-11 Avner Shemer Kit for treating skin infection
WO2007133703A2 (en) 2006-05-10 2007-11-22 Dxterity Diagnostics Detection of nucleic acid targets using chemically reactive oligonucleotide probes
US8568790B2 (en) 2006-05-31 2013-10-29 Medihoney Pty Ltd. Medicinal compositions containing honey
US20080021068A1 (en) 2006-07-24 2008-01-24 Akorn, Inc. Aqueous gel formulation and method for inducing topical anesthesia
US20090123527A1 (en) 2006-07-24 2009-05-14 Akorn, Inc. Method of inducing topical anesthesia and transdermal patch
WO2008027069A1 (en) 2006-08-21 2008-03-06 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction employing fluid
US8249695B2 (en) 2006-09-29 2012-08-21 Tearscience, Inc. Meibomian gland imaging
WO2008041177A2 (en) 2006-10-02 2008-04-10 I-Shine Danmark Aps A dispensing device and a method of using the device
US8090426B2 (en) 2006-10-27 2012-01-03 Felder Robin A Microelectronic biosensor plug
US20080102122A1 (en) * 2006-10-31 2008-05-01 Shivkumar Mahadevan Antimicrobial polymeric articles, processes to prepare them and methods of their use
WO2008058034A1 (en) 2006-11-03 2008-05-15 Qlt Inc. Methods of treating dermatological disorders or conditions
WO2008068866A1 (en) 2006-11-30 2008-06-12 Menicon Co., Ltd. Ophthalmic composition
US20080312194A1 (en) 2007-02-28 2008-12-18 Ousler Iii George W Methods and compositions for normalizing meibomian gland secretions
US20100152201A1 (en) 2007-03-12 2010-06-17 Nektar Therapeutics Oligomer-Antihistamine Conjugates
WO2008116029A1 (en) 2007-03-19 2008-09-25 Wisconsin Alumni Research Foundation Modulation of bacterial quorum sensing with synthetic ligands
US20080318939A1 (en) * 2007-06-22 2008-12-25 Whitten Jeffrey P Methods for treating ophthalmic disorders
US8128968B2 (en) 2007-08-29 2012-03-06 Tissuetech, Inc. Compositions and methods for treating Demodex infestations
JP5668476B2 (ja) 2007-10-08 2015-02-12 オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物
WO2009058387A2 (en) 2007-11-02 2009-05-07 Nektar Therapeutics Al, Corporation Oligomer-nitroimidazole anti-infective conjugates
US8246589B2 (en) 2008-02-05 2012-08-21 Marx Alvin J Precision lid retracting eyedropper device
US8734408B2 (en) 2008-02-05 2014-05-27 Alvin J. Marx Automated eyedrop delivery system with eyelid retracting legs
US20110059925A1 (en) 2008-03-26 2011-03-10 Eric Donnenfeld Methods for improving lid margin and tear film function and treatment of lid margin disease using tetracycline family antibiotics
US20090259204A1 (en) 2008-04-14 2009-10-15 Shabty Galdeti Method and Device for Applying Eye Drops
JP5552482B2 (ja) 2008-04-30 2014-07-16 キュー エル ティー インク． 複合涙管挿入物および関連する方法
US9072580B2 (en) 2008-05-07 2015-07-07 Joseph Alvino Combination eye cup and drop dispenser
US8716238B2 (en) 2008-07-10 2014-05-06 Allergan, Inc. Cyclosporin derivatives for treating ocular and dermal diseases and conditions
WO2010033800A2 (en) 2008-09-19 2010-03-25 Alacrity Biosciences, Inc. Tetracycline stabilizing formulations
CN101418020B (zh) 2008-12-12 2011-09-07 北京师范大学 99mTc标记二巯基丁二酸甲硝唑酯类配合物及制备方法和应用
US8216195B2 (en) 2009-01-07 2012-07-10 Roger Li-Chung Wu Dispenser cap for eye-drop container
US9888839B2 (en) 2009-04-01 2018-02-13 Tearscience, Inc. Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on dry eye tear film characteristic analysis and dry eye symptoms
DK2424374T3 (en) 2009-05-01 2018-05-07 Advanced Vision Res Inc Detergent compositions and methods for using the same
WO2011006079A2 (en) 2009-07-10 2011-01-13 Lyotropoic Therapeutics, Inc. Ophthalmic formulations of reversed liquid crystalline phase materials and methods of using
CN101612161A (zh) 2009-08-07 2009-12-30 魏谠全 一种眼药组合物及其制剂
WO2011044563A2 (en) 2009-10-10 2011-04-14 The Board Of Trustees Of The Leland Stanford Junior University Il-17 family cytokine compositions and uses
CN102038953B (zh) 2009-10-14 2012-07-18 上海昊海生物科技股份有限公司 一种眼科手术前局部麻醉用组合物及其制备方法和用途
US9033941B2 (en) 2009-10-22 2015-05-19 Anakin Llc Eye dropper alignment apparatus and method for using same
ES2752008T3 (es) 2009-10-30 2020-04-02 Intratus Inc Métodos y composiciones para la liberación sostenida de fármacos
WO2011068786A2 (en) 2009-12-02 2011-06-09 Bridge Pharma, Inc. Treating xerophthalmia with compounds increasing meibomian gland secretion
EP2347749A1 (en) 2010-01-22 2011-07-27 Innovaider ApS Handheld apparatus for eye-washing
US20110218241A1 (en) 2010-03-06 2011-09-08 Cacao Bio-Technologies, Llc Antiviral epicatechins, epicatechin oligomers, or thiolated epicatechins from theobroma cacao for treatment of genital warts
US20170196732A1 (en) 2010-03-11 2017-07-13 Alvin J. Marx Strip Cartridge Sterile Eyedrop Delivery System with Eyelid Retracting Legs
AU2011235002B2 (en) 2010-03-31 2016-08-11 Ocuject, Llc Device and method for intraocular drug delivery
US8304840B2 (en) 2010-07-29 2012-11-06 Taiwan Semiconductor Manufacturing Company, Ltd. Spacer structures of a semiconductor device
US20120093876A1 (en) 2010-10-13 2012-04-19 Aciex, Inc. Ophthalmic Formulations, Methods Of Manufacture And Methods of Normalizing Meibomian Gland Secretions
CN104758921A (zh) 2010-11-08 2015-07-08 希尔洛有限公司 缓冲的眼用组合物以及使用其的方法
WO2012082659A1 (en) 2010-12-13 2012-06-21 Cress Jonathan H Disposable dispenser drop diverter
JP5952302B2 (ja) 2010-12-29 2016-07-13 ニチャミン、ルイス・ディー 眼の治療のための方法及びキット
WO2012092375A1 (en) 2010-12-29 2012-07-05 Inspire Pharmaceuticals, Inc. Method for treating dry eye
WO2012092378A1 (en) 2010-12-29 2012-07-05 Inspire Pharmaceuticals, Inc. Method for treating blepharitis
AU2012209184B2 (en) 2011-01-26 2017-06-15 Allergan, Inc. Androgen composition for treating an opthalmic condition
KR101181302B1 (ko) 2011-05-04 2012-09-10 주식회사 블리스팩 재밀봉이 가능한 안구용 액제 포장용 블리스터 용기
MX360666B (es) 2011-05-12 2018-11-13 Foresight Biotherapeutics Inc Composiciones de yodopovidona estables con antiinflamatorios esteroides y no esteroides.
CN103998464A (zh) 2011-05-20 2014-08-20 学校法人庆应义塾 新型金属蛋白质及其制造方法以及含有所述金属蛋白质的角结膜疾病的预防或治疗剂
WO2013003731A2 (en) 2011-06-29 2013-01-03 Insite Vision Incorporated Methods of treating recurrent meibomian glands disorder and thereby decreasing the frequency of recurrence
US9205241B2 (en) 2011-07-12 2015-12-08 Warsaw Orthopedic, Inc. Medical devices and methods comprising an adhesive material
WO2013040623A1 (en) 2011-09-21 2013-03-28 ARGY, Philip Nathan Apparatus and method for fluid delivery
US9510972B2 (en) 2012-01-04 2016-12-06 Sight Sciences, Inc. Dry eye treatment systems
ITFI20120044A1 (it) 2012-03-01 2013-09-02 Biodue Spa Formulazione ad uso oftalmico comprendente olio di jojoba.
CN104254339B (zh) 2012-04-16 2020-01-21 路博润高级材料公司 用于治疗和/或护理皮肤和/或粘膜的化合物和它们在化妆品组合物或药物组合物中的用途
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
EP2664330A1 (de) 2012-05-15 2013-11-20 F. Holzer GmbH Zusammensetzung und Arzneimittel enthaltend Omega-3-Fettsäuren sowie einen Glucosaminoglucan
CA2881010A1 (en) 2012-08-06 2014-02-13 Baylor College Of Medicine Therapeutics dispensing device and methods of making same
CA2881025A1 (en) 2012-08-10 2014-02-13 Miklos B. Korodi Eye drop device
CA2888647A1 (en) 2012-11-20 2014-05-30 Revive Therapeutics Inc. The use of bucillamine in the treatment of gout
US9211397B2 (en) 2012-12-19 2015-12-15 Senju Usa, Inc. Patch for treatment of eyelid disease containing clobetasol
EP2934400A1 (en) 2012-12-19 2015-10-28 Glaxo Group Limited Guide device for a liquid dispenser
CN105025906B (zh) 2012-12-21 2020-08-25 阿克生物科技公司 来自鱼孵化液的化妆品组合物
GB201300227D0 (en) 2013-01-07 2013-02-20 Cooper Clifford S Eye drop dispenser bottle
WO2014117010A2 (en) 2013-01-24 2014-07-31 Rigel Pharmaceuticals, Inc. Composition for ophthalmic administration
US9610385B2 (en) 2013-03-07 2017-04-04 Abbott Cardiovascular Systems Inc. Method of fabricating an implantable medical device comprising a rapamycin derivative
CA2908634A1 (en) 2013-04-03 2014-10-09 Bullseye Dropper, Llc Eyedropper with improved stability and method of administering a liquid onto the surface of the eye
US9987235B2 (en) 2013-08-01 2018-06-05 Nicholas L. Abbott Methods and compositions for modifying mucous membranes
HUE14755117T2 (hu) 2013-08-14 2018-12-28 Kalvista Pharmaceuticals Ltd Plazma-kallikrein inhibitorok
US10213336B2 (en) 2013-09-20 2019-02-26 Ocunelis Llc Eye drop assist apparatus
CA3246118A1 (en) 2013-10-07 2025-02-21 Ocuject, Llc Intraocular delivery devices and methods therefor
CN113559105B (zh) 2014-01-29 2026-06-23 维奥姆治疗有限公司 抗性痤疮的治疗
EP3139903B1 (en) 2014-05-07 2019-07-03 Croma-Pharma Gesellschaft m.b.H. Aqueous ophthalmic solution and method for treating dry eye syndrome
WO2015187997A1 (en) 2014-06-04 2015-12-10 Tersus Pharmaceuticals, LLC METHODS OF TREATING CHRONIC DRY EYE DISEASE USING C16:1n7 PALMITOLEATE AND DERIVATIVES THEREOF
CN107405306A (zh) 2014-09-19 2017-11-28 奥叙拉尔有限公司 眼部药物组合物
US9072581B1 (en) 2014-09-25 2015-07-07 King Saud University Eye dropper positioning and guiding apparatus
JP2017532139A (ja) 2014-10-16 2017-11-02 ブルズアイ・ドロッパー・エルエルシー 定量点眼器、および眼の表面への定量投与方法
WO2016066195A1 (en) 2014-10-29 2016-05-06 Laboratoire Medidom Sa Heat-sterilized formulation comprising chitosan and process of preparation thereof
US20160199405A1 (en) 2015-01-12 2016-07-14 Paul Sutich Method and Topical Composition for the Treatment of Rosacea and Skin Erythema Using Selenium Sulfide
TW201636026A (zh) 2015-03-03 2016-10-16 日油股份有限公司 滴眼劑及其所包含之共聚物之用途
WO2016196989A1 (en) * 2015-06-03 2016-12-08 Senju Usa, Inc. Topical composition
WO2017055924A2 (en) 2015-09-28 2017-04-06 M.G. Therapeutics Ltd. Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion
CN105439958A (zh) 2015-11-06 2016-03-30 吉首大学 一类甲硝唑衍生物尿素酶抑制剂及其合成和用途
CN105456287B (zh) 2015-12-03 2017-06-30 大有药业扬州有限公司 二硫化硒超微粉体及其制备方法
US10772889B2 (en) 2015-12-21 2020-09-15 Abbott Laboratories Liquid nutritional composition containing 5-methyltetrahydrofolic acid
CN205459330U (zh) 2016-02-04 2016-08-17 张晨明 赶压式睑板腺功能障碍治疗装置
EP3235476B1 (en) 2016-04-18 2022-01-19 Plum Safety ApS Eye opening device
CA3020713A1 (en) 2016-04-19 2017-10-26 Azura Ophthalmics Ltd. Compositions for the treatment of hyperkeratosis disorders
US20190231788A1 (en) 2016-06-16 2019-08-01 Almirall, S.A. Compositions comprising timolol and an anti-inflammatory agent
WO2018027122A1 (en) 2016-08-05 2018-02-08 Infield Medical Llc Medicament dispenser
BR112019003561B1 (pt) 2016-08-31 2022-11-22 Apple Inc Sistema e método para melhorar uma exatidão de um dispositivo para ser usado junto ao corpo e determinar um movimento do braço de um usuário
WO2018044758A1 (en) 2016-09-02 2018-03-08 Eye Drop Imaging Technology, Llc Fluid dispensing system and method of use
US20190183676A1 (en) 2016-09-02 2019-06-20 Eye Drop Imaging Technology, Llc Fluid Dispensing System and Method of Use
CN106727285A (zh) 2017-01-13 2017-05-31 福元药业股份有限公司 一种软膏油脂性基质及其使用方法
CA3057569A1 (en) 2017-03-29 2018-10-04 Azura Ophthalmics Ltd. Agents for increasing meibomian gland lipid secretion
US11315016B2 (en) 2017-10-16 2022-04-26 Illumina, Inc. Deep convolutional neural networks for variant classification
CN108210081A (zh) 2018-01-05 2018-06-29 中国人民解放军第四军医大学 一种双用手柄
JP6501096B1 (ja) 2018-03-30 2019-04-17 真一 芦田 薬剤供給眼用器具
IL259550B (en) 2018-05-23 2021-09-30 Alexander Barash Apparatus for eye treatment
EP3833631A4 (en) 2018-08-10 2022-04-20 Azura Ophthalmics Ltd DISPENSER FOR ACCURATE EXTRACTION OF A SEMI-SOLID PRODUCT
PE20211169A1 (es) 2018-10-15 2021-06-30 Burgos Alejandro Gamboa Aplicador de soluciones oftalmicas en envases de monodosis y un kit que contiene el mismo
US11439533B2 (en) 2019-02-28 2022-09-13 Syed Shadman HOSSAIN Eye drop dispensing apparatus
JP7723603B2 (ja) 2019-04-12 2025-08-14 アズーラ オフサルミックス エルティーディー． コンタクトレンズ不快感を処置するための組成物および方法
US20220233350A1 (en) 2019-04-14 2022-07-28 Marcus Van Gorden Ocular medication delivery apparatus
AU2020259997B2 (en) 2019-04-18 2025-08-07 Azura Ophthalmics Ltd. Compounds and methods for the treatment of ocular disorders
CA3142608A1 (en) * 2019-06-04 2020-12-10 Cocoon Biotech Inc. Silk-based products, formulations, and methods of use
CN114980895A (zh) 2019-11-04 2022-08-30 阿祖拉眼科有限公司 针对蠕形螨及其相关病症的计量剂量
WO2021091402A1 (es) 2019-11-05 2021-05-14 Gamboa Burgos Alejandro Kit para soluciones oftálmicas en frascos de gotas con tapa rosca
WO2021136968A2 (en) 2020-01-02 2021-07-08 Azura Ophthalmics Ltd. Manufacturing of selenium disulfide compositions
WO2021140419A1 (en) 2020-01-08 2021-07-15 Azura Ophthalmics Ltd. Device for administering drug to eyelid
EP4087655A4 (en) 2020-01-10 2024-02-21 Azura Ophthalmics Ltd INSTRUCTIONS FOR COMPOSITION AND SENSITIVITY
CA3196145A1 (en) 2020-10-21 2022-04-28 Azura Ophthalmics Ltd. Compounds and methods for the treatment of ocular disorders
EP4232458A4 (en) 2020-10-21 2024-10-02 Azura Ophthalmics Ltd COMPOUNDS AND METHODS FOR THE TREATMENT OF OCULAR DISEASES
CN116635032A (zh) 2020-10-21 2023-08-22 阿祖拉眼科有限公司 用于治疗眼部病症的化合物和方法
KR20240024992A (ko) 2021-06-24 2024-02-26 아주라 오프탈믹스 엘티디 시력 개선을 위한 조성물 및 방법
TW202327641A (zh) 2021-09-14 2023-07-16 美商三葉草治療有限公司 使用經修飾之fgf-1多肽之治療方法
WO2023067387A2 (en) 2021-10-20 2023-04-27 Azura Ophthalmics Ltd. Compounds and methods for the treatment of dermal and ocular disorders
CN114989375B (zh) 2022-06-09 2023-05-26 北京化工大学 一种两亲嵌段聚合物和放化疗纳米增敏剂及其制备方法
WO2024100454A2 (en) 2022-11-11 2024-05-16 Azura Ophthalmics Ltd. Composition and methods for improving signs and symptoms of ocular disorders
US20260216173A1 (en) 2022-12-20 2026-07-30 Azura Ophthalmics Ltd. Compounds and methods for the treatment of dermal and ocular disorders
US20260109705A1 (en) 2022-12-20 2026-04-23 Azura Ophthalmics Ltd. Compounds and methods for the treatment of ocular disorders
WO2025012700A2 (en) 2023-07-07 2025-01-16 Azura Ophthalmics Ltd. Compositions and methods for the treatment of autoimmune disorders
WO2025012701A2 (en) 2023-07-07 2025-01-16 Azura Ophthalmics Ltd. Administration of keratolytics to ocular and periocular surfaces

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107105669A (zh) * 2014-10-19 2017-08-29 姆吉医疗有限公司 用于治疗睑板腺功能障碍的组合物和方法
CN109310665A (zh) * 2016-04-14 2019-02-05 阿祖拉眼科有限公司 用于治疗睑板腺功能障碍的二硫化硒组合物
US20180303906A1 (en) * 2017-04-19 2018-10-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Il-24 to treat inflammatory diseases
CN114980957A (zh) * 2019-11-04 2022-08-30 阿祖拉眼科有限公司 针对眼内或眼周病症的计量剂量

Also Published As

Publication number Publication date
WO2021140417A2 (en) 2021-07-15
CA3166357A1 (en) 2021-07-15
JP2023510499A (ja) 2023-03-14
US11517586B2 (en) 2022-12-06
US20210401877A1 (en) 2021-12-30
WO2021140417A3 (en) 2021-08-26
JP7796016B2 (ja) 2026-01-08
US20230346832A1 (en) 2023-11-02
EP4087655A4 (en) 2024-02-21
JP2026052691A (ja) 2026-03-24
US20220409657A1 (en) 2022-12-29
US12697352B2 (en) 2026-08-04
EP4087655A2 (en) 2022-11-16

Similar Documents

Publication Publication Date Title
US20230346832A1 (en) Instructions for composition and sensitivity
ES2627405T3 (es) Composiciones que comprenden brimonidina para el tratamiento del eritema
US20100204335A1 (en) Kit and composition for eyelash growth
ES2730411T3 (es) Composiciones mejoradas que comprenden brimonidina para un tratamiento seguro y eficaz de la telangiectasia
US11369812B2 (en) Non-irritating, non-blurring ophthalmic sunscreen
RU2688170C2 (ru) Композиция и способ для лечения кожных состояний
US11690800B2 (en) Non-irritating, non-blurring, photostable ophthalmic sunscreen composition
US4626530A (en) Treatment of eye inflammation with biphenamine
Scheife et al. Photosensitizing potential of ofloxacin
JP2023510499A5 (enExample)
EP3190887B1 (en) Methods for treating and preventing ocular diseases, disorders, and conditions with melanin
EP3484586A1 (en) Non-irritating, non-blurring, photostable ophthalmic sunscreen composition
WO2018013732A1 (en) Non-irritating, non-blurring, photostable ophthalmic sunscreen composition
CN104053425B (zh) 基于胶体银和脱氧核糖核酸的协同组合的医学护肤组合物
GB2177917A (en) Dermatologically active substances
WO2017075019A1 (en) Eye drops
TWI896143B (zh) 一種有效延緩及治療近視的藥物組合物
Fijałkowska et al. Rosacea–diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part 2. Treatment
KR20110099044A (ko) 후안부에 유효농도의 활성제를 전달하기 위한 국소 안용액 조성물
KR20250079339A (ko) 습성 연령관련 황반변성의 예방 또는 치료를 위한 약학 조성물
WO2020152527A1 (en) Ophthalmic pharmaceutical compositions based on vitamins, amino acids and minerals for treating immature cataract
JP2021517139A (ja) 選択的ｓｙｋ阻害剤の使用方法および医薬組成物
UA112244C2 (uk) Спосіб лікування "мішків" під очима за індріксоном
HK1234605A1 (en) Methods for treating and preventing ocular diseases, disorders, and conditions with melanin
HK1234605B (en) Methods for treating and preventing ocular diseases, disorders, and conditions with melanin

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination