CN1150839C - Health food with blood pressure and blood lipoid regulating function and its production process - Google Patents
Health food with blood pressure and blood lipoid regulating function and its production process Download PDFInfo
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Abstract
The present invention relates to a health food having the function of regulating blood pressure and blood fat, and a preparation method thereof. The health food is prepared through the following steps: concentrating and freeze-drying fresh celery juice and 40 to 95% of the ethanol extract of celery residues to obtain celery extract; extracting useful components from the raw medical material of notoginseng; merging the extracts, respectively washing with water and ethanol to get eluent; then, concentrating and freeze-drying the eluent to get panax notoginseng saponins; using ethanol to extract useful components from the raw medical material of ginseng; merging the extracts to get an extract; freeze-drying the extract in the vacuum to get ginseng total saponins powder; preparing 20 to 80 portions of celery extract and 80 to 20 portions of panax notoginseng saponins and/or ginseng total saponins into oral preparation forms of health food, such as granules, tablets, capsules, etc., wherein the raw medical material of notoginseng can be the roots and/or the stems and the leaves of notoginseng, and the raw medical material of ginseng can be ginseng root, the basal part of ginseng stem, the stem and the leaf of ginseng and/or ginseng fruit.
Description
Technical field that the present invention belongs to
The present invention relates to a kind of health food, particularly have health food of regulating blood pressure, adjusting blood fat and anti-aging effects and preparation method thereof.
Background technology
The human living standard improves day by day and along with the generally prolongation of human longevity, the pursuit of life and quality of life is improved constantly.But, some such as obesity, tobacco and wine, take the photograph that salt is too much, shortage is movable, psychological stress and from work and hazards such as other aspect height keen competition and pressure but serious threat people's health, the disease of hypertension, high fat of blood, other and aging and inferior health association has become frequently-occurring disease, the common disease of serious harm China and world's most countries people's health and quality of life.Since the 1950's, hypertension, hyperlipemic patients and sub-health population are multiplied, almost by geometric growth.For example, present global hyperpietic has exceeded 600,000,000, and China patient surpasses 100,000,000.Along with the acceleration of aging population, the hypertension growth will continue---and quantitatively the speed with every year 10% constantly increases, and has the trend of rejuvenation.Simultaneously, it except itself be a kind of angiocardiopathy and, also be the main hazard factor that causes coronary heart disease and cranial vascular disease, brought huge misery and white elephant for patient, family and society.Numerous studies show that: to hypertension, high fat of blood prevents early and stablizes treatment and healthy lifestyles, can make 75% hypertension and high fat of blood and complication thereof obtain prevention and control.And the medicine of taking hypotensive and reducing blood lipid for a long time chemical synthetic drug especially, not only the curative effect fluctuation is bigger, and takes medicine for a long time because of need, and medicine is also more because of accumulating the toxic and side effect that causes.Therefore, how to develop a kind of draw materials natural, determined curative effect, and can take for a long time and toxic and side effect is little and have the health food of regulating blood pressure, regulating blood fat and antifatigue effect concurrently and become one and satisfy the development project that attracts people's attention that consumers in general pursue the eager needs of high-quality life for special population.
Put down in writing according to supplement to the Herbal: celery can " go to press disease "; " a thousand pieces of gold. food therapy " say its energy " beneficial biceps is gone latent heat, controls five kinds of jaundice ", Shennong's Herbal and Compendium of Material Medica are seen in its medicinal record the earliest.Among the people also be usually used in hypotensive and the treatment epilepsy.Shanghai hypertension research institute report celery water decoction had hypotensive effect clinically in 1958; Grandson's generation tin report celery crude extract had hypotensive effect in 1964.The institute of Materia Medica,Chinese Academy of Medical Sciences scientific research personnel has carried out system research to celery active ingredient from the seventies, finds that it mainly contains: flavonoids, as: apiin (apigenin; 5,7,4 '-trihydroxyflavone), apiolin (apiin), Butylphthalide (DL-3-n-butylphalide) etc.; (people [J.Agric FoodChem 45:590 such as Crozier, 1997] find through advanced person's extraction, separation, purifying and identification of means analysis, main active substances in the water extract is a flavonoids, wherein apiin can reach 1783.2mg/kg, digicitrine can reach 333.4mg/kg, and flavone compound has better curative effect to ischemic heart disease.) bergapten, volatile oil, organic acid, carrotene, vitamin C, sweet mellow wine, inositol and nicotinic acid etc.Wherein, the pharmacological research to the celery main component shows: the celery crude extract has tangible hypotensive effect to rabbit, dog intravenous injection; Apiolin has hypotensive effect, the blood vessel perfusion can cause blood vessel dilatation, use arch of aorta perfusion method, can resist the booster reaction that nicotine, antabac cause, also can cause step-down, effect to maincenter studies show that it has sedation to animal, has effect of smooth muscle spasmolysis contraction and anti-gastric-ulcer effect, and tumour cell is had apoptosis-induced effect; Has the multiple protein kinases, as EGFR-TK (PTK), protein kinase C (PCK), mitogen activated protein kinase (MAP), phosphinositides-3-kinase inhibiting activity, and the PTK specificity suppresses to suppress generation and the expression of the NOSmRNA that IL-1 and LPS induce, apiolin produces thereby suppress NO, so may be to work by the activity that suppresses PTK.Butylphthalide has: anti-cerebral hemorrhage effect; Improve CBF; Platelet aggregation there is the obvious suppression effect; The calcium channel of pair cell and calcium content raise inhibitory action; Improve energetic supersession and injury of mitochondria is had protective effect; Improve the memory disorders that brain trauma and cerebral ischemia cause.
In addition, celery is except that containing above apiolin and Butylphthalide with clear and definite hypotensive effect, and the modern analysis means prove again and contain generally acknowledged component for reducing blood fat 3-n-butyl 2-benzo (c) furanone in the celery.In its water extract, also contain component for reducing blood fat, people [Planta Med.61:18 such as Singapore scholar Tsi, 1995] celery is pulverized, the water extracting, water extract is concentrated, powder is made in freeze drying then, again powder is mixed to feed in the feed and raised rat, dosage is 10g/ rat/d, 4 week, found that the celery water extract can obviously reduce cholesterol in serum, LDL-C and content of triglyceride, and can increase the capacity of decomposition of liver, the effect of its blood fat of tool adjusting still is described triglycerides.
In addition, learn that by Medline and internet retrieval except that the health care of step-down, lipopenicillinase, Herba Apii graveolentis extract still has the blood circulation of the brain of improvement, strengthen memory, pre-anti-cancer, functions such as protection liver.
Characteristics of the present invention are to prepare the goods that are rich in nutrition and Secondary Metabolism of Plant compound in the celery with the extraction process of reasonable science, thereby have solved the problem of the non-trophic factors of nutrient in the abundant extraction celery and biologically active.While is instant also: edible a spot of extract can reach and need eat the health-care effect that a large amount of celeries can reach.Meanwhile, notoginseng total saponin powder and/or the TSPG powder of in this invention, still being furnished with 80～20% weight portions.
The Chinese medicine pseudo-ginseng is Araliaceae, has another name called pseudo-ginseng, Panax pseudoginseng etc., and ancient book is its flavor efficacy on the books early.As, put down in writing according to Compendium of Material Medica: " hemostasis of pseudo-ginseng root, the blood that looses, analgesic therapy." supplementary Amplifications of the Compendium of Materia Medica claims: " ginseng qi-tonifying the first, pseudo-ginseng enrich blood second.Flavor with and merit also waits, the old friend also claims to say Panax pseudoginseng, is the most precious person in the medicine.”
Modern study shows that the functional component of pseudo-ginseng is mainly notoginseng total saponin (Ginsenoside Rb
1, Rg
1, Rg
2) and a small amount of panaxoside (Ra, Rb
2, Rb and Re), still contain glycosides displayed in addition.Therefore, the chemical composition in the pseudo-ginseng is similar to genseng.As, the multiple sapogenin that separates from the total saponin of pseudo-ginseng suede root mainly is panoxadiol and panaxatriol class saponin, total saponin content is up to 12%.Monomer has the Ginsenoside Rb
1, Rb
2, Rc, Ra, Re, Rf, Rg
1, Rg
2, nine kinds of Rh etc.Because pseudo-ginseng is similar to the known chemical composition of genseng, so the two pharmacological action is also quite approximate.Pharmacology and clinical research to pseudo-ginseng show, notoginseng total saponin has dual regulation excited and that suppress to nervous centralis: pseudo-ginseng total saponin from leaves lumbar injection, can significantly alleviate mouse because of the caused spontaneous activity of central stimulant caffeine sodium benzoate, reduce the mice convulsion number of times that pentylenetetrazole brought out, and prolong the incubation period of fainting from fear.Can also improve the pain reaction threshold due to the hot plate method in addition, both can resist the destruction that M-choline retardance thorn anisodine obtains memory, but antagonist protein matter synthetic inhibitor resistance inhibitor action that memory is consolidated again.The Ilexonin A clinical treatment angina pectoris and the cerebrovascular sequelae that contain multiple arasaponin and flavones preparation are effective, and electrocardiogram also has part to improve.Notoginseng total saponin can reduce excitability, self-disciplining and the shrinkage of guinea-pig heart room flesh.Therefore, the someone thinks that pseudo-ginseng is a kind ofly can increase the comparatively desirable medicine that the myocardial nutritional flow amount does not increase oxygen demand again.Pseudo-ginseng root saponin has the effect that suppresses platelet aggregation.Notoginseng total saponin is the same with the gen-seng haulms alcohol extract, and excited hypophysis-adrenocortical effect is arranged; Pseudo-ginseng also has the effect of immunomodulator, and is similar to genseng, can make low or too high immune response recover normal, and the not normal immune response of interference body also can be eliminated superfluous antigen in the blood, prevents the generation of immune complex.Effect to the metabolism aspect studies show that Radix Notoginseng powder can reduce rabbit TL level, and content of triglyceride obviously reduces.Notogineng Extract mainly contains the saponin of panaxatriol, and blood sugar is had dual regulation.Ilexonin A can obviously promote the synthetic of the protein of mouse liver, kidney and testis and RNA, and pseudo-ginseng root saponin can be promoted the synthetic of serum proteins and liver dna, and the two all can make mouse cardiac muscle cAMP content raise 22.6%, and cGMP content obviously reduces.Research such as woods dawn prompting, arasaponin also has certain preventive and therapeutic effect (Acta Pharmacologica Sinica, 1993 the 14th volumes, the 14th phase) for atherosclerotic generation development.
Clinically, pseudo-ginseng also is used for the common coronary heart disease of the elderly, miocardial infarction, angina pectoris more except that being used for diseases such as traumatic injury, hemorrhage due to internal injury, the swollen pain of pain, also can be used for diseases such as hypertension, high fat of blood, artery sclerosis.Unming Medical College observes with Ilexonin A treatment 853, not only coronary heart disease, angina pectoris there is better curative effect, and floaty euphoria, appetite enhancement, sleep improvement, full of vitality are arranged after taking, hypercholesterolemia and hypertriglyceridemia are all had obvious curative effects.Also there is identical curative effect in other hospitals with pseudo-ginseng coronary disease sheet or Radix Notoginseng injection.
Toxicologic study shows that notoginseng total saponin is to contain ginseng diol saponin, by animal acute toxicity, excitant, safety experiment,, do not see toxic reaction and other marked changes to the influence and the sub-acute toxicity test of small intestine, the result shows that notoginseng total saponin toxicity is lower, and safe range is bigger.
Genseng is the root of Araliaceae genseng Panax ginseng C.A.Mey..Put down in writing according to Shennong's Herbal: " clothes are made light of one's life by commiting suicide and prolonged life for a long time ".Genseng always is used as medicine with root.But in recent years, studies show that both at home and abroad that ginseng bud, cauline leaf, son had chemical composition and the pharmacological action approximate with ginseng.Modern study shows: contained main component with drug effect is a panaxoside in ginseng and the coring, has analyzed RA at present
1, RA
2, RA
3, RA
4, RA
5, RA
6, Rb
1, Rb
2, Rc, Rd, Re, Rf, R0, R4 etc.And the total saponin of the bioactivator that from ginseng reed (being the rhizome of genseng), proposes ginseng reed head, basic identical with the total saponin content in the ginseng.Isolated three kinds of sapogenins from the ginseng reed: oleanolic acid, panoxadiol, panaxatriol separates the kind saponin monomer coldest days of the year end at last, through identifying, is equivalent to panaxoside Ro, Rb
1, Rc, Rb
2, Re, Rd, Rg
2And Rg
1, and contained total saponin is higher than the ginseng root more than 2 times in the ginseng reed; The grouping saponin ginseng glycol group of gen-seng haulms, the content of panaxatriol group and oleanolic acid group all is higher than the content of ginseng, and in the ginseng leaf ginsenoside content also apparently higher than root, now isolated 11 kinds of panaxoside monomers from gen-seng haulms, wherein 8 kinds of chemical constitutions are respectively panaxoside Rh
1, Rg
1, Rg
2, Rg
3, Re, Rb
1And Rb
2Contain among the ginseng seed and the corresponding saponin of ginseng, and the former height and latter of its total saponin content, according to the study, ginseng seed's total saponin content is about 4 times of ginseng root; Contain Rb among the ginseng seed
2, Rc, Rd, Re and Rg
1, wherein Re content is up to 6%, is 30 times of ginseng root.
Pharmacology and clinical research show: an amount of panaxoside can prolong cell survival, and main effect has seemingly increased the ability of cell colony multiplication, to keep the survival ability of cell after the cell ageing.Can also promote the mitosis that the human blood lymphocyte is external, the life cycle of prolonged human amnion cell.Clinical, genseng can also improve the adaptive capacity of old man to environment, so use quite wide.
The extract of genseng can also strengthen the function of immunocompetent cell.Can promote hemopoietic function of bone marrow, promote cholesterol, phosphatide, protein, DNA synthetic of marrow, make simultaneously that karyocyte digital display work increases in red blood cell in the blood, leucocyte and the marrow.
Big quantity research also proves, genseng can stimulate acetaldehyde dehydrogenase, the butanedioic acid hydrogen enzyme of liver, the activity of malic dehydrogenase under appropriate dosage, promotes that liver cell ATP and RNA's is synthetic.To high SGPT and the SGOT that the experimental hepatic injury due to the carbon tetrachloride causes, panaxoside can make it to reduce.And to hepatomicrosome p-450 tool inducing action, thereby strengthened function of detoxification.In addition, genseng has regulation efficiency to cholesterol metabolic, can suppress the generation of hypercholesterolemia.
Genseng still has cardiotonic, and its mechanism is with the release that promotes catecholamine and suppress Na
+-K
+-ATP enzyme is relevant, thereby improves the amyocardia state.It can also reduce MCO, reduces cardiac load, reduces left ventricular pressure and heart rate.To animal used as test, the genseng low dose is slightly boosted, and is heavy dose of hypotensive, hemangiectasis, and wherein to coronary artery, cerebral blood vessel, vertebral artery, Pulmonic dilating effect is particularly remarkable.Genseng also has direct effect to the thromboxane A2 synzyme, can suppress the biosynthesis of thromboxane A2, thereby has suppressed platelet aggregation very significantly.Moreover, the almost irreversible gathering that high dense journey ADP induced platelet produces, genseng can make it depolymerization.Based on above-mentioned characteristic, clinically prevention and treatment aged coronary heart disease, cardiogenic shocks etc. of being used for more.
The ginseng reed is the same with the ginseng root, and the ability that improves body defence destructive stimulus factor and antifatigue is arranged.Zoopery shows; the total saponin of ginseng Lu also has oxygen lack resistant function; the effect of protection cardiac muscle is arranged; the same with the saponin of ginseng, stem, Ye Heguo, can dwindle experimental myocardial infarct size, myocardial cell injury sugared to lacking, that anoxic causes has protective effect; can promote that cardiac muscle cell's DNA is synthetic; and when reducing heart rate, can strengthen myocardial contractive power and coronary flow, the rat myocardium block that isoprel is caused has protective effect.These results suggest ginseng reed saponins are used for the treatment of cardiovascular disease, may obtain good effect.Ginseng reed saponin is the same with panaxoside, can improve the activity of the sodium-potassium ATP enzyme of tissues such as mouse core, liver,kidney,spleen be dirty, reduces the activity of magnesium-ATP enzyme, and zoopery shows that also joining the total saponin of Lu has antidiuretic effect.
The total saponin of ginseng Lu also has the effect of bidirectional modulation immunologic function.
Pharmacological research and clinical research to extract of Radix Ginseng stem and leaf and saponin thereof are found: 10% ginseng leaf medicinal extract can impel yeast cell growth to increase by 618 times, and ginseng root medicinal extract only increases by 33 times.Stem and leaf of Radix Ginseng saponin is irritated stomach or lumbar injection, can promote synthesizing of rat blood serum, muscle, liver, nephrocyte protein and RNA, and can promote the synthetic of the mitosis of bone marrow cell and DNA, RNA, protein, neonatal rat myocardial cell DNA biosynthesis in vitro culture also has facilitation, wherein Ginsenoside Rb
1With Rd the effect that promotes Porcine HGF is arranged; The function that promotes body nerve growth and neuroprotective cell is arranged, can delay atrophy, destruction and the death of brain cell, saponin Rg
1The formation of the conditioned reflex of mouse can be promoted, man memory power and intelligence can be improved.The Soviet Union and domestic scholars confirm that extract of Radix Ginseng stem and leaf and haulm general saponin can obviously improve the people's work ability and strengthen the energy of animal.Also can improve the non-specific resistivity of antibody, stimulate body's immunity, regulate nervous centralis, the double action and the antidiuretic activity of excited inhibition maincenter arranged.Continuous 10 days of mouse peritoneal injection ginseng stem leaves general saponin can obviously suppress the growth of transplanted sarcoma S180, also can obviously increase the body weight of tumor-bearing mice.
Sugar coated tablet treatment coronary heart disease, hyperlipidemia, vegetative nerve functional disturbance, women's climacteric syndrome, acute diabetes, transient ischemic attack, vascular pain, the cerebral artery blood supply insufficiency disorder made from ginseng stem leaves general saponin waited group, chronic bronchitis and with alcohol extract treatment Addison's disease 1299 examples of gen-seng haulms, all obtained better curative effect.Think that this product can be regulated central nervous system, improves vegetative nerve function, improved a poor appetite, antifatigue, strengthening body; To cardiovascular cardiac stimulant arranged, improve electrocardiogram, improve heart murmur, regulate heart rate and blood pressure, effects such as allevating angina pectoris, reducing blood lipid.It can also protect hematopoiesis function, except that anemia being had preferably treatment, cancer patient's blood picture during radiation and chemotherapy is kept normally, therefore can adhere to the putting of heavy dose, chemotherapy.Proof folium panacis japonici cum caule saponin has the curative effect similar to ginseng, is a kind of desirable bidirectional modulation agent.
Extract of Radix Ginseng stem and leaf or saponin can improve the most internal organs of body after one's own heart, liver, kidney and endocrine, functions of immune system; Again can antifatigue, regulate central nervous system etc. and adapt to the former state effect; Clinically diseases of old people such as coronary heart disease, cranial vascular disease, high fat of blood also there is curative effect preferably, illustrate that gen-seng haulms is to having the guaranteeing role the same with genseng because of increasing the many internal organs, the decay of multisystem function that cause age, and gen-seng haulms aboundresources, low price, be easy to extract, be suitable for as delaying senility drug use and further be applied to clinical.At present, all begun both at home and abroad to extract panaxoside with gen-seng haulms, its pharmacological action is identical with the genseng majority with clinical practice.
In recent years, people find that again ginseng seed's saponin content is also very high, are about 4 times of ginseng, and the content of monomer whose saponin Re is about 30 times of the ginseng root, and have significantly anti-ageing, strong effect and some other pharmacological actions.Can regulate, improve the elderly's endocrine function and metabolic function as it, improve the elderly's intelligence, improve senile symptom, treat some geriatric diseases; Can also improve the anti-anoxic of animal, antifatigue, the ability of high temperature resistance, low temperature is protected the adrenal cortex function that is under depleted, these undoubtedly to aging delay play a positive role.Therefore, the ginseng seed is worth more deep research and extension as a kind of clinical effective antiaging agent.
Another characteristics of the present invention promptly are, make full use of Yunnan Province of China and economize raw material sources abundant pseudo-ginseng root and cauline leaf, the extraction process of utilizing section to emulate the advanced is fully extracted the wherein contained abundant notoginseng total saponin with clear and definite pharmacologically active, and/or the surplus ginseng of using, the reed head, cauline leaf and ginseng seed extract the TSPG that obtains, again directly according to a certain ratio with have step-down, the Herba Apii graveolentis extract of lipopenicillinase activity mixes, make and have the adjusting blood pressure, regulate the health food of blood fat and antifatigue effect, than before similar product not only save and made full use of existing herb resource, the while food therapy effect is also more secure and the experiment proved that clearer and more definite: the function assessment experimental study of this health food shows, this product is in the 30-120mg/kg.Bw.d dosage range, to reducing rat TC, TG level and raising HDL-C level have certain effect.Under the situation that does not influence food-intake, can suppress the hyperlipidemia rats body weight gain effectively, and present tangible dose-effect relationship (P＜0.05, P＜0.01); Adopt own control and norepinephrine to cause models such as rat blood pressure rising, observe respectively all can obviously resist the rat blood pressure rising effect that norepinephrine causes behind this product 100 and the 200mg/kg filling stomach, the obvious rat normal arterial pressure that reduces behind the duodenal administration.Results suggest, this health food also has tangible hypotensive activity.
One of task of the present invention is: provide a kind of at hypertension, high fat of blood, such disease danger occurred frequently is arranged and subhealth symptom is arranged or the health care of the special population of trend and mid-aged population and dietotherapy need, taking convenience, clear and definite the having of effect are regulated blood pressure, regulated blood fat and antifatigue effect health food or food of special nutrients.
Two of task of the present invention provides that a kind of technology that realizes task one is simple, the preparation method of the health food of science.
One of task of the present invention realizes by following measure:
80～20 parts of Herba Apii graveolentis extracts, surplus are notoginseng total saponin powder and/or panaxoside powder, and the summation of final component is 100 parts.
Two of task of the present invention realizes by following measure, is illustrated below in conjunction with accompanying drawing.
Fig. 1 is the Herba Apii graveolentis extract preparation technology flow chart among the present invention.
Fig. 2 is preparation technology's flow chart of notoginseng total saponin powder among the present invention.
Fig. 3 is preparation technology's flow chart of panaxoside powder among the present invention.
A, get bright celery, impurity elimination, broken after cleaning, the bright Celery Juice of squeezing the juice, will filter gained is concentrated into 1/2 final vacuum freeze drying or the spray-drying that is about original volume;
B, to the rear last solid residue of squeezing the juice, with 40～95% ethanol of 2～4 times of volumes 10～70 ℃ of temperature Filter after the soaked overnight in the scope, collect filtrate, will filter again the gained filter residue with 40～95% of 2～4 times of volumes Ethanol soaks 4～48 hours in 10～70 ℃ of temperature ranges after, filter, collect filtrate, with above-mentioned twice After gained filtrate merges, be concentrated into and be about 1/2 of original volume, through vacuum freeze drying or spray-drying;
C, merging a, the dry loose freeze-dried powder of b operation gained, sealing is placed on 4～10 ℃ of dry environments In save backup;
D, with the ordinary water of 2～3 times of weight soak the pseudo-ginseng crude drug (Roots of Panax Notoginseng, cauline leaf) 20 pulverized～60min passes into and is steam heated to about 90 ℃, and is incubated 1 hour, then, filters after cooling to such an extent that soak Extract I, the gained filter residue adds the ordinary water of 3 times of weight again, and lixiviate 40min under same condition filters The leaching liquor II that removes the gred to get merges twice gained leaching liquor;
E, make adsorbent with macroporous absorbent resin, with the upper macroporous resin column of d operation gained filtrate, first water Wash 1～3 time, continuous wash 1～2 time with 10～20% ethanol, abandon or adopt cleaning solution after, again with 50～70% second Alcohol wash-out 2～3 times is collected eluent and is namely got loose through the concentrated final vacuum freeze drying of rotary evaporation, pulverizing The notoginseng total saponin powder;
F, genseng crude drug (ginseng, reed head, cauline leaf, son) is ground into the coarse granule (crossing 20 mesh sieves) of suitable granularity, measures 70% ethanol with 8 times and extract 3 hours/time altogether 2 times, merge extract, after reclaiming ethanol,, promptly get the TSPG powder with gained medicinal extract vacuum freeze drying, pulverizing;
G, with the dry Herba Apii graveolentis extract of c, e, f operation gained and notoginseng total saponin and/or TSPG by 80～20: 20～80 weight portions mix, and encapsulate.Promptly can be used for producing health food such as formulations such as tablet, capsule, granule and oral liquids;
During production, can add suitable auxiliary material such as an amount of honey, sugar, starch according to the needs of different dosage form.
Embodiment:
A, get bright celery 10kg, removal of impurities, it is broken to clean the back, squeezes the juice.The bright Celery Juice of gained is concentrated into 1/2 final vacuum freeze drying or the spray-drying that is about original volume;
B, the last residue in back of squeezing the juice, 40～95% ethanol with 3 times of volumes are filtering after the soaked overnight under 45 ℃ of temperature, collect filtrate, to filter again the gained filter residue with 40～95% ethanol of 4 times of volumes after soaking 24 hours under 45 ℃ of temperature, filter, collect filtrate, after above-mentioned twice gained filtrate is merged, be concentrated into and be about 1/2 of original volume, through vacuum freeze drying or spray-drying;
C, merge a, the dry loose freeze-dried powder of b operation gained, sealing be placed on preserve in 4 ℃ of dry environments standby;
D, soak pseudo-ginseng crude drug (pseudo-ginseng root and/or the cauline leaf) 20min that pulverizes with the ordinary water of 3 times of weight, feeding is steam heated to about 90 ℃, and be incubated 1 hour, then, filter after cooling leaching liquor I, the gained filter residue adds the ordinary water of 3 times of weight again, lixiviate 40min under same condition, filter cleaner gets leaching liquor II, and twice gained leaching liquor merged;
E, make adsorbent with macroporous absorbent resin, d operation gained filtrate is gone up macroporous resin column, wash with water earlier 2 times, continue and wash 1 time with 10% ethanol, after discarding cleaning solution, again with 55% ethanol elution 3 times, collect eluent and concentrate the final vacuum freeze drying, pulverize and promptly get the notoginseng total saponin powder that loosens through rotary evaporation;
F, with gained Herba Apii graveolentis extract and notoginseng total saponin powder weight ratio mixing, again by 2% ratio adding glidant by 38: 62---mixing behind the microcrystalline cellulose is filled in 2
#Capsules gets final product.
Claims (2)
1, a kind of preparation method with health food of regulating blood pressure, blood fat is characterized in that preparation technology is:
A, get bright celery, impurity elimination, it is broken to clean the back, and the bright Celery Juice of squeezing the juice, will filter gained is concentrated into 1/2 final vacuum freeze drying or spray-drying of original volume;
B, to squeeze the juice the back last solid residue, 40～95% ethanol with 2～4 times of volumes filter after the soaked overnight in 10～70 ℃ of temperature ranges, collect filtrate, after will filtering the gained filter residue again and in 10～70 ℃ of temperature ranges, soaking 4～48 hours with 40～95% ethanol of 2～4 times of volumes, filter, collect filtrate, after above-mentioned twice gained filtrate is merged, be concentrated into 1/2 of original volume, through vacuum freeze drying or spray-drying;
C, merge a, the dry loose freeze-dried powder of b operation gained, sealing be placed on preserve in 4～10 ℃ of dry environments standby;
D, soak the pseudo-ginseng crude drug 20～60min that pulverizes with the ordinary water of 2～3 times of weight, feeding is steam heated to 90 ℃, and be incubated 1 hour, then, filter after cooling leaching liquor I, the gained filter residue adds the ordinary water of 3 times of weight again, lixiviate 40min under same condition, filter cleaner gets leaching liquor II, and twice gained leaching liquor merged;
E, make adsorbent with macroporous absorbent resin, d operation gained filtrate is gone up macroporous resin column, wash with water earlier 1～3 time, continue and wash 1～2 time with 10～20% ethanol, after abandoning or adopting cleaning solution, again with 50～70% ethanol elutions 2～3 times, collect eluent and concentrate the final vacuum freeze drying, pulverize and promptly get the notoginseng total saponin powder that loosens through rotary evaporation;
F, the genseng crude drug was ground into the coarse granule of 20 mesh sieve granularities, extracted altogether 2 times with 8 times of amount 70% ethanol, 3 hours/time, merge extract, reclaim ethanol after, with gained medicinal extract vacuum freeze drying, pulverizing, promptly get the TSPG powder;
G, with the dry Herba Apii graveolentis extract of c, e, f operation gained and notoginseng total saponin and/or TSPG by 80～20: 20～80 weight portions mix, help again with proper auxiliary materials, by corresponding the preparation requirement make the health food of sheet, particle, capsule and peroral dosage form.
2, the described health food preparation method of claim 1 is characterized in that: but make pseudo-ginseng crude drug pseudo-ginseng root and/or cauline leaf in the raw material, but genseng crude drug ginseng, reed head, cauline leaf and/or ginseng seed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02113281XA CN1150839C (en) | 2002-01-25 | 2002-01-25 | Health food with blood pressure and blood lipoid regulating function and its production process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02113281XA CN1150839C (en) | 2002-01-25 | 2002-01-25 | Health food with blood pressure and blood lipoid regulating function and its production process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1370472A CN1370472A (en) | 2002-09-25 |
| CN1150839C true CN1150839C (en) | 2004-05-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB02113281XA Expired - Fee Related CN1150839C (en) | 2002-01-25 | 2002-01-25 | Health food with blood pressure and blood lipoid regulating function and its production process |
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| Country | Link |
|---|---|
| CN (1) | CN1150839C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455390B (en) * | 2008-11-27 | 2011-12-28 | 成都润馨堂药业有限公司 | Nutrient health-care food capable of adjusting blood pressure and preparation method thereof |
| CN102524635A (en) * | 2010-12-27 | 2012-07-04 | 程辉 | Ginseng-sweet tea extract and preparation method thereof |
| CN106722881B (en) * | 2016-12-14 | 2021-06-22 | 上海天天商务实业有限公司 | Health-care mushroom juice for preventing and/or improving cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN114209723B (en) * | 2021-12-30 | 2023-10-03 | 辽宁上药好护士药业（集团）有限公司 | Composition for assisting in reducing blood fat, product containing composition and application |
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2002
- 2002-01-25 CN CNB02113281XA patent/CN1150839C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1370472A (en) | 2002-09-25 |
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