CN106728108A - A kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla - Google Patents

A kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla Download PDF

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CN106728108A
CN106728108A CN201710085643.4A CN201710085643A CN106728108A CN 106728108 A CN106728108 A CN 106728108A CN 201710085643 A CN201710085643 A CN 201710085643A CN 106728108 A CN106728108 A CN 106728108A
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gynostemma pentaphylla
hypertension
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张育松
黄轲
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Fujian Kang Shi Mei Biotechnology Co Ltd
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    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/42Cucurbitaceae (Cucumber family)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
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    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention belongs to field of Chinese herbal, and in particular to a kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla, it is made up of following raw material:12 15 parts of hawthorn, 20 30 parts of gynostemma pentaphylla, 20 30 parts of duck wheat, 10 15 parts of cassia seed, 10 15 parts of the red sage root, 8 12 parts of Herba Lysimachiae foenumgraeci, 8 12 parts of STEVIA REBAUDIANA, 10 15 parts of bitter leaves.The present invention can soften expansion of blood vessels, increase CF, reduce serum cholesterol with hawthorn, gynostemma pentaphylla, the taste of duck wheat three as monarch drug in a prescription, carry out lowering and stabilizing blood pressure;And with cassia seed, bitter leaves, red sage root taste ministerial drug, to reach the effect of the lipid-loweringing that helps digestion, and helped with Herba Lysimachiae foenumgraeci and STEVIA REBAUDIANA with seasoning, improve pained mouthfeel, and strengthen the effect of hypertension and hyperlipemia.

Description

A kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla
Technical field
The invention belongs to field of Chinese herbal, and in particular to a kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla.
Background technology
The medicine for the treatment of hypertension includes chemical synthetic drug and Chinese patent drug at present.Conventional chemical synthetic drug has at present:Diuresis Depressor, vascular smooth muscle expansion medicine, angiotensin converting enzyme inhibitor (ACEI), calcium antagonist, adrenocepter resistance Off-drug, Angiotensin II receptor antagonist (AIIRB) etc..These medicines are primarily directed to the symptom of hypertension, to hinder Blood pressure that is disconnected or alleviating body itself rises mechanism and reaches the purpose for controlling blood pressure.Body regulation in itself can thus be destroyed Mechanism, drug side-effect is inevitable;Meanwhile, in order to persistently play a role, big drug needs to take daily, to the work of patient Inconvenience is brought as life.Treatment hypertension, the medicine of high fat of blood, especially more now, are mostly Western medicine, it is necessary to patient is long-term Take, long-term taking Western medicine can bring very big side effect to liver.The present invention provides a kind of hypertension and hyperlipemia Chinese medicine composition, long Phase takes and is free from side effects.
The content of the invention
It is an object of the invention to provide a kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla, with hawthorn part, gynostemma pentaphylla, Duck wheat is monarch drug in a prescription, and assistant reaches hypertension and hyperlipemia effect with cassia seed, the red sage root, Herba Lysimachiae foenumgraeci, STEVIA REBAUDIANA, bitter leaves ministerial drug.
To realize the purpose of the present invention, adopt the following technical scheme that:
A kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla, is made up of following raw material:Hawthorn 12-15 parts, gynostemma pentaphylla It is 20-30 parts, duck wheat 20-30 parts, cassia seed 10-15 parts, red sage root 10-15 parts, Herba Lysimachiae foenumgraeci 8-12 parts, STEVIA REBAUDIANA 8-12 parts, bitter Fourth 10-15 parts.
The preparation method of the hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla, comprises the following steps that:
(1)Hawthorn, the red sage root are respectively crushed into fine powder, 100-200 eye mesh screens are crossed, powder is mixed;
(2)By gynostemma pentaphylla, cymose buckwheat rhizome, cassia seed, bitter leaves and step(1)Mixed-powder mixes, and adds 3 times of water of quality, 90 DEG C Lower to extract 1 hour, filtering obtains extract solution;Add 2 times of 80wt% ethanol solutions of quality to mix, be centrifuged after standing 10h, obtain Extract;
(3)By step(2)Extract mixes with Herba Lysimachiae foenumgraeci, STEVIA REBAUDIANA, the infusion 2h at 100 DEG C, filtering, removes filter residue, obtains Described Chinese medicine composition.
Hawthorn:Sour sweet, tepor.Digestion gathered food, scattered blood stasis.Control phlegm and retained fluid, feeling of fullness pediatric milk food stagnation.Food digesting stomach fortifying, promoting the circulation of qi dissipates The stasis of blood.For meat stagnation, gastric ulcer fullness, hyperlipemia.
Gynostemma pentaphylla:Bitter;Micro-sweet;It is cool in nature.There are eliminating inflammation and expelling toxin, cough-relieving apophlegmatic, blood pressure preventing and treating blood is adjusted in reducing blood lipid Bolt, prevents and treats cardiovascular disease, adjusts blood sugar, promotees sleep, delays aging, and anti-anticancer, enhance immunity adjusts human physiological functions.
Organic acid in duck wheat its not only reduction blood fat, and be that synthesis serves in terms of Human Physiology regulation must Prostaglandin and cranial nerve component one of important component, vascular sclerosis can be prevented, be to be very useful to the elderly's Flavone component in health food, and duck wheat has obvious reducing blood sugar and blood fat function.
Herba Lysimachiae foenumgraeci, pharmacological action widely, and has correlation, with good medical value and economic worth.For example Vascular endothelial cell damage can cause the diseases such as thrombus, atherosclerosis, hypertension, and sweet basil is while antithrombotic, step-down Being likely to Human Umbilical Vein Endothelial Cells has certain protective effect;And the damage of endothelial cell is attacked with inflammation, the strong phase closely of oxidation Close, so the mechanism of sweet basil protection endothelial cell is likely to and anti-inflammatory, it is anti-oxidant relevant.In addition, sweet basil can suppress tumour cell Migration, so as to play the effect of its anti-tumor metastasis, its mechanism also suppresses platelet aggregation with sweet basil, so as to prevent knurl bolt from being formed It is relevant.
STEVIA REBAUDIANA(Stevia rebaudiana Hemsl)It is composite family sweetleaf Chrysanthemum herbaceos perennial, originates in south The alpine meadow that Paraguay of U.S. and Brazil have a common boundary, existing Fujian China, Beijing, Hebei, Shaanxi, Jiangsu, Anhui, Hunan, Yunnan etc. Introduce a fine variety on ground.Stevioside leaf glycosides containing synanthrin 6-12%, fine work is white powder, is a kind of crude sweet low in calories, sugariness high Taste agent, is one of raw material of food and pharmaceutical industries.With regulation blood pressure, softening blood vessel, reduction blood fat, hypoglycemic, glucose in urine, suppression Bacterium hemostasis, analgesia, fat-reducing and beauty, nourishing Yin and promoting production of body fluid, help digest, promote pancreas, spleen and stomach function and clearing heat and detoxicating function.
The present invention has advantages below compared with the prior art:
The present invention can soften expansion of blood vessels, increase CF, reduce blood with hawthorn, gynostemma pentaphylla, the taste of duck wheat three as monarch drug in a prescription Clearing gallbladder sterol, carrys out lowering and stabilizing blood pressure;And with cassia seed, bitter leaves, red sage root taste ministerial drug, to reach the effect of the lipid-loweringing that helps digestion, and with Herba Lysimachiae foenumgraeci Helped with STEVIA REBAUDIANA with seasoning, improve pained mouthfeel, and strengthen the effect of hypertension and hyperlipemia.
Specific embodiment
For further disclosure is of the invention rather than limitation, below in conjunction with example, the present invention is described in further detail.
Embodiment 1
A kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla, is made up of following raw material:12 parts of hawthorn, gynostemma pentaphylla 20 Part, 20 parts of duck wheat, 10 parts of cassia seed, 10 parts of the red sage root, 8 parts of Herba Lysimachiae foenumgraeci, 8 parts of STEVIA REBAUDIANA, 10 parts of bitter leaves.
The preparation method of the hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla, comprises the following steps that:
(1)Hawthorn, the red sage root are respectively crushed into fine powder, 100-200 eye mesh screens are crossed, powder is mixed;
(2)By gynostemma pentaphylla, cymose buckwheat rhizome, cassia seed, bitter leaves and step(1)Mixed-powder mixes, and adds 3 times of water of quality, 90 DEG C Lower to extract 1 hour, filtering obtains extract solution;Add 2 times of 80wt% ethanol solutions of quality to mix, be centrifuged after standing 10h, obtain Extract;
(3)By step(2)Extract mixes with Herba Lysimachiae foenumgraeci, STEVIA REBAUDIANA, the infusion 2h at 100 DEG C, filtering, removes filter residue, obtains Described Chinese medicine composition.
Embodiment 2
A kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla, is made up of following raw material:13 parts of hawthorn, gynostemma pentaphylla 25 Part, 25 parts of duck wheat, 15 parts of cassia seed, 10 parts of the red sage root, 10 parts of Herba Lysimachiae foenumgraeci, 10 parts of STEVIA REBAUDIANA, 10 parts of bitter leaves.
The preparation method of the hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla, comprises the following steps that:
(1)Hawthorn, the red sage root are respectively crushed into fine powder, 100-200 eye mesh screens are crossed, powder is mixed;
(2)By gynostemma pentaphylla, cymose buckwheat rhizome, cassia seed, bitter leaves and step(1)Mixed-powder mixes, and adds 3 times of water of quality, 90 DEG C Lower to extract 1 hour, filtering obtains extract solution;Add 2 times of 80wt% ethanol solutions of quality to mix, be centrifuged after standing 10h, obtain Extract;
(3)By step(2)Extract mixes with Herba Lysimachiae foenumgraeci, STEVIA REBAUDIANA, the infusion 2h at 100 DEG C, filtering, removes filter residue, obtains Described Chinese medicine composition.
Embodiment 3
A kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla, is made up of following raw material:15 parts of hawthorn, gynostemma pentaphylla 30 Part, 30 parts of duck wheat, 10 parts of cassia seed, 14 parts of the red sage root, 12 parts of Herba Lysimachiae foenumgraeci, 12 parts of STEVIA REBAUDIANA, 15 parts of bitter leaves.
The preparation method of the hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla, comprises the following steps that:
(1)Hawthorn, the red sage root are respectively crushed into fine powder, 100-200 eye mesh screens are crossed, powder is mixed;
(2)By gynostemma pentaphylla, cymose buckwheat rhizome, cassia seed, bitter leaves and step(1)Mixed-powder mixes, and adds 3 times of water of quality, 90 DEG C Lower to extract 1 hour, filtering obtains extract solution;Add 2 times of 80wt% ethanol solutions of quality to mix, be centrifuged after standing 10h, obtain Extract;
(3)By step(2)Extract mixes with Herba Lysimachiae foenumgraeci, STEVIA REBAUDIANA, the infusion 2h at 100 DEG C, filtering, removes filter residue, obtains Described Chinese medicine composition.
The animal lipid Control release of the hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla:
Material:The embodiment of the present invention 2 makes sample by oneself.The daily recommended intake 100mg/ kgBW of human body(60Kg is calculated).
Experimental animal:Cleaning grade BALB/C male mices, body weight 40-50g, single cage is raised.It is dynamic by Shanghai Si Laike experiments Thing Co., Ltd provides, credit number:SCXK(Shanghai)2007-0005.
High lipid food formula is:70% basal feed, 1 % cholesterol, 15% yolk, 14% lard.
Method:From healthy male mice 50, take tail blood and survey serum total cholesterol (TC), triglycerides (TG) and height Density lipoprotein (HDL-C), five groups are randomly divided into according to TC levels, negative control group, high-fat adiposity control group and it is low, in, Three tested material dosage groups high, dosage is respectively 100 mg/ kgBW, 500 mg/ kgBW, 1000mg/ kgBW, equivalent to people 1 times, 5 times, 10 times of body recommended amounts, every group of 10 animals.Other each groups give in addition to negative control group is to normal diet High lipid food is fed.Each dosage group gavage of tested material gives the tested material of various dose, and two control group gavages give same volume Pure water, gives tested material 30d by 1ml/ 100gBW gavages.Once a day, weigh weekly once.High-fat adiposity is compareed Group then gives the pure water of same volume.Fasting 16h before off-test, after weighing broken end take blood survey serum total cholesterol (TC), Triglycerides (TG) and HDL-C (HDL-C).Obtained experimental data is carried out using " SPSS 20 " software Statistical analysis.
Influence of the sample of 1 embodiment of table 2 to lipid of mice index
Influence of the sample of 1 embodiment of table 2 to lipid of mice index
Note:With negative control group ratio:##P ﹤ 0.01.With fat control group ratio high:* P ﹤ 0.01.
The result listed by table 1, high-fat adiposity control animals serum total cholesterol (TC), triglycerides after experiment (TG), serum High Density Lipoprotein Cholesterol (HDL-C) is higher than negative control group, and difference has highly significant (P< 0.01).Illustrate that fat animal model high is manufactured successfully, and the serum total cholesterol (TC) of each dosage group animal and each dosage group glycerine Three esters (TG) are below high-fat adiposity control group, and difference has conspicuousness (P<Or highly significant (P 0.05)<0.01).
The animal blood pressure Control release of the hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla:
Material:The sample of the embodiment of the present invention 2.Captopril tablets(25mg specifications)Shanghai Hua Surname Pharmaceutical Co., Ltd. produces.
Experimental animal:Spontaneous hypertensive rat (SHR) 56, male, body weight 260g--300g, blood pressure
160-200mmHg, is provided, credit number by Shanghai Slac Experimental Animal Co., Ltd.:SCXK(Shanghai)2007- 0005。
Method:3 groups, every group 15 are randomly divided into by blood pressure.It is divided into experimental group, blank control group and positive controls.It is real Test homogeneous without significant difference, each group basic blood pressure value between preceding each group rat, data are shown in Table 2.
Positive controls feed captopril, 1.0mg/kg (equivalent to 3 times of the dose,equivalent of people's dosage), daily Twice, feed one week.Blank control group feeding clear water, twice daily, feeds one week.The sample that experimental group is prepared with embodiment 2, 500mg crude drugs/kg (equivalent to 5 times of people's dose), have fed for first day in three times, subsequently feed clear water.After one week, survey Amount record each group rat tail artery pressure value, as shown in table 3.Stop administration afterwards, three groups of rats feed clear water, after one week, Surveying record each group rat tail artery pressure value, as shown in table 4.
Table 2 is administered preceding each group rat artery pressure value
Table 3 is administered one week after each group rat tail artery pressure value
Table 4 be discontinued one week after each group rat tail artery pressure value
From table 3 and table 4 as can be seen that after being discontinued one week, the systolic pressure of positive controls, diastolic pressure and mean arterial pressure contrast stop It is significantly increased before medicine, the contrast of the systolic pressure of experimental group, diastolic pressure and mean arterial pressure has declined before being discontinued.
The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent with Modification, should all belong to covering scope of the invention.

Claims (3)

1. a kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla, it is characterised in that:It is made up of following raw material:Hawthorn It is 12-15 parts, gynostemma pentaphylla 20-30 parts, duck wheat 20-30 parts, cassia seed 10-15 parts, red sage root 10-15 parts, Herba Lysimachiae foenumgraeci 8-12 parts, sweet 8-12 parts and bitter leaves 10-15 parts of leaf chrysanthemum.
2. the hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla according to claim 1, it is characterised in that:By following weight portion Raw material is made:13 parts of hawthorn, 25 parts of gynostemma pentaphylla, 25 parts of duck wheat, 15 parts of cassia seed, 10 parts of the red sage root, 10 parts of Herba Lysimachiae foenumgraeci, STEVIA REBAUDIANA 10 parts and 10 parts of bitter leaves.
3. it is a kind of prepare as claimed in claim 1 containing gynostemma pentaphylla hypertension and hyperlipemia Chinese medicine composition method, it is characterised in that:Tool Body step is as follows:
(1)Hawthorn, the red sage root are respectively crushed into fine powder, 100-200 eye mesh screens are crossed, powder is mixed;
(2)By gynostemma pentaphylla, cymose buckwheat rhizome, cassia seed, bitter leaves and step(1)Mixed-powder mixes, and adds 3 times of water of quality, 90 DEG C Lower to extract 1 hour, filtering obtains extract solution;Add 2 times of 80wt% ethanol solutions of quality to mix, be centrifuged after standing 10h, obtain Extract;
(3)By step(2)Extract mixes with Herba Lysimachiae foenumgraeci, STEVIA REBAUDIANA, the infusion 2h at 100 DEG C, filtering, removes filter residue, obtains Described Chinese medicine composition.
CN201710085643.4A 2017-02-17 2017-02-17 A kind of hypertension and hyperlipemia Chinese medicine composition containing gynostemma pentaphylla Pending CN106728108A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108271893A (en) * 2018-04-13 2018-07-13 黄继斌 Blood fat reducing tea
CN108853379A (en) * 2018-09-28 2018-11-23 福建农林大学 A kind of hypertension and hyperlipemia compound preparation and preparation method thereof
CN109007788A (en) * 2018-08-23 2018-12-18 辽宁兴海制药有限公司 A kind of blood-fat reducing composition and its preparation method and application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101755973A (en) * 2010-01-24 2010-06-30 徐继斌 Three highs (hypertension, hyperlipidemia and hypertension) lowering and fat dissolving health protection tea prepared by taking gynostemma pentaphylla as main raw material

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101755973A (en) * 2010-01-24 2010-06-30 徐继斌 Three highs (hypertension, hyperlipidemia and hypertension) lowering and fat dissolving health protection tea prepared by taking gynostemma pentaphylla as main raw material

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
柏传红等: "山楂绞股蓝代茶饮治疗高脂血症31例", 《山楂绞股蓝代茶饮治疗高脂血症31例 *
洪文旭: "《天然药物四百味》", 30 September 2010, 中医古籍出版社 *
老中医养生堂: "《本草纲目中草药使用图鉴》", 30 April 2016, 福建科学技术出版社 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108271893A (en) * 2018-04-13 2018-07-13 黄继斌 Blood fat reducing tea
CN109007788A (en) * 2018-08-23 2018-12-18 辽宁兴海制药有限公司 A kind of blood-fat reducing composition and its preparation method and application
CN108853379A (en) * 2018-09-28 2018-11-23 福建农林大学 A kind of hypertension and hyperlipemia compound preparation and preparation method thereof

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