CN1370472A - Health food with blood pressure and blood lipoid regulating function and its production process - Google Patents
Health food with blood pressure and blood lipoid regulating function and its production process Download PDFInfo
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Abstract
Disclosed are health food with blood pressure and blood lipoid regulating function and its preparation process in the present invention. During its preparation, fresh celery juice and ethanol extractive of celery dreg are concentrated and freeze-dried to obtain celery extractive; notoginseng extractive is water and ethanol washed, concentrated and freeze-dried to obtain to obtain notoginseng general saponin, ethanol extractive of ginseng is vacuum freeze-dried to obtain ginseng general saponin powder; and celery extractive in 20-80 portions and notoginseng general saponin and/or ginseng general saponin powder in 20-80 portions are produced into granule, table, capsule and oral health food.
Description
Technical field that the present invention belongs to
The present invention relates to a kind of health food, particularly have health food of blood pressure regulation, blood lipid regulation and anti-aging effects and preparation method thereof.
Background technology
The human living standard improves day by day and along with the generally prolongation of human longevity, the pursuit of life and quality of life is improved constantly.But, some such as obesity, tobacco and wine, take the photograph that salt is too much, shortage is movable, mental tension and from work and risk factors such as other aspect height keen competition and pressure but serious threat people's health, the disease of hypertension, hyperlipidemia, other and aging and subhealth state association has become serious harm China and world's most countries people's health and the frequently-occurring disease of quality of life, commonly encountered diseases.Since the 1950's, hypertension, hyperlipemic patients and sub-health population are multiplied, almost by geometric growth.For example, present global hyperpietic has exceeded 600,000,000, and China patient surpasses 100,000,000.Along with the acceleration of aged tendency of population, the hypertension growth will continue---and quantitatively the speed with every year 10% constantly increases, and has the trend of rejuvenation.Simultaneously, it except itself be a kind of cardiovascular disease and, also be the main hazard factor that causes coronary heart disease and cerebrovascular disease, brought huge misery and white elephant for patient, family and society.Numerous studies show that: to hypertension, hyperlipidemia prevents early and stablizes treatment and healthy lifestyles, can make 75% hypertension and hyperlipidemia and complication thereof obtain prevention and control.And the medicine of taking blood pressure lowering and blood fat reducing for a long time chemical synthetic drug especially, not only the curative effect fluctuation is bigger, and takes medicine for a long time because of need, and medicine is also more because of accumulating the toxic and side effects that causes.Therefore, how to develop a kind of draw materials natural, determined curative effect, and can take for a long time and toxic and side effects health food little and that have blood pressure regulation, blood lipid regulation and antifatigue effect concurrently has become one and satisfies the development project that attracts people's attention that consumers in general pursue the eager needs of high-quality life for special population.
Put down in writing according to supplement to the Herbal: Herba Apii graveolentis can " go to press disease "; " a thousand pieces of gold. dietetic therapy " say its energy " beneficial biceps is gone latent heat, controls five kinds of jaundice ", Shennong's Herbal and Compendium of Material Medica are seen in its medicinal record the earliest.Blood pressure lowering and the treatment epilepsy of also being usually used among the people.Shanghai hypertension institute report Herba Apii graveolentis water decoction had hypotensive effect clinically in 1958; Grandson's generation stannum report Herba Apii graveolentis crude extract had hypotensive effect in 1964.The institute of Materia Medica,Chinese Academy of Medical Sciences scientific research personnel has carried out systematic study to the Herba Apii graveolentis effective ingredient from the seventies, finds that it mainly contains: flavonoid, as: apiin (apigenin; 5,7,4 '-trihydroxyflavone), apigenin (apiin), Butylphthalide (DL-3-n-butylphalide) etc.; (people [J.Agric FoodChem 45:590 such as Crozier, 1997] find through advanced person's extraction, separation, purification and identification of means analysis, main active substances in the water extract is a flavonoid, wherein apiin can reach 1783.2mg/kg, digicitrine can reach 333.4mg/kg, and flavone compound has better curative effect to ischemic heart desease.) bergapton, volatile oil, organic acid, carotene, vitamin C, mannitol, cyclohexanhexanol and nicotinic acid etc.Wherein, the pharmacological research to the Herba Apii graveolentis main component shows: the Herba Apii graveolentis crude extract has tangible hypotensive effect to rabbit, dog intravenous injection; Apigenin has hypotensive effect, the blood vessel perfusion can cause vasodilation, use the aortic arch perfusion method, can resist the booster reaction that nicotine, antabac cause, also can cause blood pressure lowering, effect to maincenter studies show that it has sedation to animal, has effect of smooth muscle spasmolysis contraction and anti-gastric-ulcer effect, and tumor cell is had apoptosis-induced effect; Has the multiple protein kinases, as tyrosine kinase (PTK), Protein kinase C (PCK), mitogen activated protein kinase (MAP), phosphinositides-3-kinase inhibiting activity, and the PTK specificity suppresses to suppress generation and the expression of IL-1 and the inductive NOSmRNA of LPS, apigenin produces thereby suppress NO, so may be to work by the activity that suppresses PTK.Butylphthalide has: anti-cerebral hemorrhage effect; Improve blood flow; Platelet aggregation there is the obvious suppression effect; The calcium channel of pair cell and calcium content raise inhibitory action; Improve energy metabolism and mitochondrial injury is had protective effect; Improve the dysmnesia that cerebral trauma and cerebral ischemia cause.
In addition, Herba Apii graveolentis is except that containing above apigenin and Butylphthalide with clear and definite hypotensive effect, and the modern analysis means prove again and contain generally acknowledged component for reducing blood fat 3-n-butyl 2-benzo (c) furanone in the Herba Apii graveolentis.In its water extract, also contain component for reducing blood fat, people [Planta Med.61:18 such as Singapore scholar Tsi, 1995] Herba Apii graveolentis is pulverized, the water extracting, water extract is concentrated, powder is made in lyophilization then, again powder is mixed feed rat in the feedstuff, dosage is 10g/ rat/d, 4 week, found that the Herba Apii graveolentis water extract can obviously reduce cholesterol in serum, low-density lipoprotein cholesterol and content of triglyceride, and can increase the capacity of decomposition of liver, illustrate that it still has an effect of blood lipid regulation triglyceride.
In addition, learn that by Medline and the Internet retrieval except that the health care of blood pressure lowering, blood fat reducing, Herba Apii graveolentis extract still has functions such as the cerebral blood circulation of improvement, hypermnesis, prophylaxis of cancer, the liver protecting.
Characteristics of the present invention are to prepare the goods that are rich in nutrition and Secondary Metabolism of Plant chemical compound in the Herba Apii graveolentis with the extraction process of reasonable science, thereby have solved the problem of the non-trophic factors of nutrient in the abundant extraction Herba Apii graveolentis and biologically active.While is instant also: edible a spot of extract can reach and need eat the health-care effect that a large amount of Herba Apii graveolentis can reach.Meanwhile, Radix Notoginseng total arasaponins powder and/or the Radix Ginseng total saponins powder of in this invention, still being furnished with 80～20% weight portions.
The Chinese medicine Radix Notoginseng is Araliaceae, has another name called Radix Notoginseng, Panax pseudoginseng etc., and ancient book is its flavor efficacy on the books early.As, put down in writing according to Compendium of Material Medica: " Radix Notoginseng hemostasis, the blood that looses, analgesic therapy." supplementary Amplifications of the Compendium of Materia Medica claims: " ginseng qi-tonifying the first, Radix Notoginseng enrich blood second.Flavor with and merit also waits, the old friend also claims to say Panax pseudoginseng, is the most precious person in the medicine.”
Modern study shows that the functional component of Radix Notoginseng is mainly Radix Notoginseng total arasaponins (Ginsenoside Rb
1, Rg
1, Rg
2) and a small amount of ginsenoside (Ra, Rb
2, Rb and Re), still contain flavonoid glycoside in addition.Therefore, the chemical constituent in the Radix Notoginseng is similar to Radix Ginseng.As, isolating multiple ruscogenin from the total Saponin of Radix Notoginseng floss root mainly is panoxadiol and panaxatriol's class Saponin, total saponin content is up to 12%.Monomer has the Ginsenoside Rb
1, Rb
2, Rc, Ra, Re, Rf, Rg
1, Rg
2, nine kinds of Rh etc.Because Radix Notoginseng is similar to the known chemical composition of Radix Ginseng, so the two pharmacological action is also quite approximate.Pharmacology and clinical research to Radix Notoginseng show, Radix Notoginseng total arasaponins has dual regulation excited and that suppress to nervus centralis: Radix Notoginseng total saponin from leaves lumbar injection, can significantly alleviate mice because of the caused spontaneous activity of central stimulant caffeine and sodium benzoate, reduce the mice convulsion number of times that pentylenetetrazole brought out, and prolong the incubation period of fainting from fear.Can also improve the pain threshold of responsiveness due to the hot plate method in addition, both can resist the destruction that M-choline blocker Anisodine obtains memory, but antagonist protein matter synthetic inhibitor resistance inhibitor action that memory is consolidated again.The angina pectoris of Ilexonin A clinical treatment and the cerebrovascular sequelae that contain multiple arasaponin and flavones preparation are effective, and electrocardiogram also has part to improve.Radix Notoginseng total arasaponins can reduce irritability, self-disciplining and the contractility of guinea-pig heart room flesh.Therefore, the someone thinks that Radix Notoginseng is a kind ofly can increase the comparatively ideal medicine that the myocardial nutritional flow amount does not increase oxygen consumption again.The Radix Notoginseng Saponin has the effect of anticoagulant.Radix Notoginseng total arasaponins is the same with the Stem and leaf of Radix Ginseng alcohol extract, and excited hypophysis-adrenocortical effect is arranged; Radix Notoginseng also has the effect of immunomodulator, and is similar to Radix Ginseng, can make low or too high immunoreation recover normal, and the not normal immunoreation of interference body also can be eliminated superfluous antigen in the blood, prevents the generation of immune complex.Effect to the metabolism aspect studies show that Radix Notoginseng powder can reduce rabbit TL level, and content of triglyceride obviously reduces.Radix Notoginseng extract mainly contains panaxatriol's Saponin, and blood glucose is had dual regulation.Ilexonin A can obviously promote the synthetic of the protein of mouse liver, kidney and testis and RNA, and the Radix Notoginseng Saponin can be promoted the synthetic of serum proteins and liver dna, and the two all can make mouse cardiac muscle cAMP content raise 22.6%, and cGMP content obviously reduces.Research such as woods dawn prompting, arasaponin also has certain preventive and therapeutic effect (Acta Pharmacologica Sinica, 1993 the 14th volumes, the 14th phase) for atherosclerotic generation development.
Clinically, Radix Notoginseng also is used for the common coronary heart disease of old people, myocardial infarction, angina pectoris more except that being used for diseases such as traumatic injury, hemorrhage due to internal injury, the swollen pain of pain, also can be used for diseases such as hypertension, hyperlipidemia, arteriosclerosis.Unming Medical College observes and treats 853 examples with Ilexonin A, not only coronary heart disease, angina pectoris there is better curative effect, and sense of euphoria, appetite enhancement, sleep improvement, full of vitality are arranged after taking, hypercholesterolemia and hypertriglyceridemia are all had obvious curative effects.Also there is identical curative effect in other hospitals with Radix Notoginseng coronary disease sheet or Radix Notoginseng injection.
Toxicologic study shows that Radix Notoginseng total arasaponins is to contain ginseng diol saponin, by animal acute toxicity, zest, safety experiment,, do not see toxic reaction and other significant changes to the influence and the sub-acute toxicity test of small intestinal, the result shows that Radix Notoginseng total arasaponins toxicity is lower, and safety range is bigger.
Radix Ginseng is the root of Araliaceae Radix Ginseng Panax ginseng C.A.Mey..Put down in writing according to Shennong's Herbal: " clothes are made light of one's life by commiting suicide and prolonged life for a long time ".Radix Ginseng always is used as medicine with root.But in recent years, studies show that both at home and abroad that Rhizoma Ginseng, stem and leaf, son had and proximate chemical constituent of Radix Ginseng and pharmacological action.Modern study shows: contained main component with drug effect is the ginsenoside in Radix Ginseng and the root hair, has analyzed RA at present
1, RA
2, RA
3, RA
4, RA
5, RA
6, Rb
1, Rb
2, Rc, Rd, Re, Rf, R0, R4 etc.And the total Saponin of the bioactive substance that from ginseng reed (being the Radix Ginseng rhizome), proposes ginseng reed head, basic identical with the total saponin content in the Radix Ginseng.Isolated three kinds of ruscogenin from the ginseng reed: oleanolic acid, panoxadiol, the panaxatriol separates the kind saponin monomer coldest days of the year end at last, through identifying, is equivalent to ginsenoside Ro, Rb
1, Rc, Rb
2, Re, Rd, Rg
2And Rg
1, and contained total Saponin is higher than the ginseng root more than 2 times in the ginseng reed; The grouping saponin ginseng glycol group of Stem and leaf of Radix Ginseng, the content of panaxatriol's group and oleanolic acid group all is higher than the content of Radix Ginseng, and in the Rhizoma panacis majoris ginsenoside content also apparently higher than root, now isolated 11 kinds of panaxoside monomers from Stem and leaf of Radix Ginseng, wherein 8 kinds of chemical constitutions are respectively ginsenoside Rh
1, Rg
1, Rg
2, Rg
3, Re, Rb
1And Rb
2Contain in the Fructus Ginseng and the corresponding Saponin of Radix Ginseng, and the former height and latter of its total saponin content, according to the study, the Fructus Ginseng total saponin content is about 4 times of ginseng root; Contain Rb in the Fructus Ginseng
2, Rc, Rd, Re and Rg
1, wherein Re content is up to 6%, is 30 times of ginseng root.
Pharmacology and clinical research show: an amount of ginsenoside can prolong cell survival, and main effect has seemingly increased the ability of cell colony multiplication, to keep the survival ability of cell after the cell ageing.Can also promote the mitosis that the human blood lymphocyte is external, the life cycle of prolonged human amnion cell.Clinical, Radix Ginseng can also improve the adaptive capacity of old man to environment, so use quite wide.
The function of all right enhance immunity competent cell of the extract of Radix Ginseng.Can hemopoietic, promote cholesterol, phospholipid, protein, DNA synthetic of bone marrow, make simultaneously that nucleated cell digital display work increases in erythrocyte in the blood, leukocyte and the bone marrow.
Big quantity research also proves, Radix Ginseng can stimulate aldehyde dehydrogenase, the succinic acid hydrogen enzyme of liver, the activity of malic dehydrogenase under appropriate dosage, promotes that hepatocyte ATP and RNA's is synthetic.To high SGPT and the SGOT that the experimental hepatic injury due to the carbon tetrachloride causes, the ginsenoside can make it to reduce.And to hepatomicrosome p-450 tool inducing action, thereby strengthened function of detoxification.In addition, Radix Ginseng has regulation efficiency to cholesterol metabolism, can suppress the generation of hypercholesterolemia.
Radix Ginseng still has cardiotonic, and its mechanism is with the release that promotes catecholamine and suppress Na
+-K
+-ATP enzyme is relevant, thereby improves amyocardia's state.It can also reduce myocardial oxygen consumption, reduces cardiac load, reduces left ventricular pressure and heart rate.To laboratory animal, the Radix Ginseng low dose is slightly boosted, heavy dose of blood pressure lowering, and blood vessel dilating, wherein to coronary artery, cerebral blood vessel, vertebral artery, Pulmonic dilating effect is particularly remarkable.Radix Ginseng also has direct effect to the thromboxane A2 synzyme, can suppress the biosynthesis of thromboxane A2, thereby has suppressed platelet aggregation very significantly.Moreover, the reversible hardly gathering that high dense journey ADP induced platelet produces, Radix Ginseng can make it depolymerization.Based on above-mentioned characteristic, clinically prevention and treatment aged coronary heart disease, cardiogenic shock etc. of being used for more.
The ginseng reed is the same with the ginseng root, and the body of raising defence destructive stimulus factor and antifatigue ability are arranged.Zoopery shows; the total Saponin of ginseng Lu also has oxygen lack resistant function; the effect of protection cardiac muscle is arranged; the same with the Saponin of Radix Ginseng, stem, Ye Heguo, can dwindle experimental myocardial infarct size, myocardial cell injury sugared to lacking, that anoxia causes has protective effect; can promote that the DNA of myocardial cell is synthetic; and when reducing heart rate, can strengthen myocardial contraction and coronary flow, the rat myocardium block that isoproterenol is caused has protective effect.These results suggest ginseng reed Saponins are used for the treatment of the cardiovascular diseases, may obtain good effect.Ginseng reed Saponin is the same with the ginsenoside, can improve the activity of the sodium-potassium ATP enzyme of tissues such as mouse core, liver,kidney,spleen be dirty, reduces the activity of magnesium-ATP enzyme, and zoopery shows that also joining the total Saponin of Lu has antidiuretic effect.
The total Saponin of ginseng Lu also has the effect of two-ways regulation immunologic function.
Pharmacological research and clinical research to extract of Radix Ginseng stem and leaf and Saponin thereof are found: 10% Rhizoma panacis majoris extractum can impel yeast cell growth to increase by 618 times, and ginseng root extractum only increases by 33 times.Stem and leaf of Radix Ginseng saponin is irritated stomach or lumbar injection, can promote synthesizing of rat blood serum, muscle, liver, nephrocyte protein and RNA, and can promote the mitosis of medullary cell and DNA, RNA, proteinic synthetic, neonatal rat myocardial cell DNA biosynthesis to In vitro culture also has facilitation, wherein Ginsenoside Rb
1With Rd the effect that promotes cell growth factor is arranged; The function that promotes body nerve growth and neuroprotective cell is arranged, can delay atrophy, destruction and the death of brain cell, Saponin Rg
1The formation of the trained reflex of mice can be promoted, man memory power and intelligence can be improved.The Soviet Union and domestic scholars confirm that extract of Radix Ginseng stem and leaf and haulm general saponin can obviously improve the people's work ability and strengthen the energy of animal.Also can improve the non-specific resistivity of antibody, stimulate body's immunity, regulate nervus centralis, the dual function and the antidiuretic activity of excited inhibition maincenter arranged.Continuous 10 days of mouse peritoneal injection stem and leaf of Radix Ginseng total saponins can obviously suppress the growth of transplanted sarcoma S180, also can obviously increase the body weight of tumor-bearing mice.
The sugar coated tablet treatment coronary heart disease made from stem and leaf of Radix Ginseng total saponins, hyperlipemia, autonomic nervous dysfunction, climacteric syndrome, acute diabetes, transient ischemic attack, vascular pain, cerebral arteries blood supply insufficiency disorder Hou Qun, chronic tracheitis and with ethanol extract treatment Addison's disease 1299 examples of Stem and leaf of Radix Ginseng all obtain better curative effect.Think that this product can be regulated the central nervous system, improved vegetative nerve function, appetite stimulator, resisting fatigue, strengthening body; Cardiovascular there is heart tonifying, improves electrocardiogram, improves arrhythmia, regulates effects such as heart rate and blood pressure, allevating angina pectoris, blood fat reducing.It can also hemopoietic function protecting, except that anemia being had treatment preferably, cancer patient's hemogram during radiation and chemotherapy is kept normally, therefore can adhere to the putting of heavy dose, chemotherapy.Reference's Rhizoma panacis majoris Saponin has the curative effect similar to Radix Ginseng, is a kind of ideal two-ways regulation agent.
Extract of Radix Ginseng stem and leaf or Saponin can improve the most internal organs of body after one's own heart, liver, kidney and endocrine, functions of immune system; Again can resisting fatigue, regulate central nervous system and wait the former state effect that adapts to; Clinically senile disease such as coronary heart disease, cerebrovascular disease, hyperlipidemia also there is curative effect preferably, illustrate that Stem and leaf of Radix Ginseng is to having the guaranteeing role the same with Radix Ginseng because of increasing the many internal organs, the decay of multisystem function that cause age, and Stem and leaf of Radix Ginseng aboundresources, low price, be easy to extract, be suitable for as the slow down aging drug use and further be applied to clinical.At present, all begun both at home and abroad to extract the ginsenoside with Stem and leaf of Radix Ginseng, its pharmacological action is identical with the Radix Ginseng majority with clinical practice.
In recent years, people find that again the Fructus Ginseng saponin content is also very high, are about 4 times of Radix Ginseng, and the content of monomer whose Saponin Re is about 30 times of the ginseng root, and have tangible defying age, strong effect and some other pharmacological actions.Can regulate, improve old people's endocrine function and metabolic function as it, improve old people's intelligence, improve senile symptom, treat some Senile disease; Can also improve the anoxia enduring of animal, resisting fatigue, high temperature resistance, cryogenic ability are protected the adrenal cortex function that is under depleted, these undoubtedly to aging delay play a positive role.Therefore, Fructus Ginseng is worth more deep research and extension as a kind of clinical effective antiaging agent.
Another characteristics of the present invention promptly are, make full use of Yunnan Province of China and economize raw material sources abundant Radix Notoginseng and stem and leaf, the extraction process of utilizing section to emulate the advanced is fully extracted the wherein contained abundant Radix Notoginseng total arasaponins with clear and definite pharmacologically active, and/or utilize Radix Ginseng, the reed head, stem and leaf and Fructus Ginseng extract the Radix Ginseng total saponins that obtains, again directly according to a certain ratio with have blood pressure lowering, the active Herba Apii graveolentis extract mix homogeneously of blood fat reducing, make and have blood pressure regulation, the health food of blood lipid regulation and antifatigue effect, than before similar product not only save and made full use of existing herb resource, the while food therapy effect is also more secure and the experiment proved that clearer and more definite: the function assessment experimentation of this health food shows, this product is in the 30-120mg/kg.Bw.d dosage range, to reducing rat TC, TG level and raising HDL-C level have certain effect.Under the situation that does not influence food-intake, can suppress the hyperlipidemia rats body weight gain effectively, and present tangible dose-effect relationship (P＜0.05, P＜0.01); Adopt own control and norepinephrine to cause models such as rat blood pressure rising, observe respectively all can obviously resist the rat blood pressure rising effect that norepinephrine causes behind this product 100 and the 200mg/kg filling stomach, the obvious rat normal arterial pressure that reduces behind the duodenal administration.Results suggest, this health food also has tangible hypotensive activity.
One of task of the present invention is: provide a kind of at hypertension, hyperlipidemia, such disease danger occurred frequently is arranged and subhealth symptom is arranged or the health care of the special population of trend and mid-aged population and dietetic therapy need, taking convenience, clear and definite health food with blood pressure regulation, blood lipid regulation and antifatigue effect or the food of special nutrients of effect.
Two of task of the present invention provides that a kind of technology that realizes task one is simple, the preparation method of the health food of science.
One of task of the present invention realizes by following measure:
80～20 parts of Herba Apii graveolentis extract, surplus are Radix Notoginseng total arasaponins powder and/or ginsenoside's powder, and the summation of final component is 100 parts.
Two of task of the present invention realizes by following measure, is illustrated below in conjunction with accompanying drawing.
Fig. 1 is the Herba Apii graveolentis extract preparation technology flow chart among the present invention.
Fig. 2 is preparation technology's flow chart of Radix Notoginseng total arasaponins powder among the present invention.
Fig. 3 is preparation technology's flow chart of ginsenoside's powder among the present invention.
A, get bright Herba Apii graveolentis, roguing, it is broken to clean the back, and the bright Sucus Oenanthes Javanicae of squeezing the juice, will filter gained is concentrated into 1/2 final vacuum lyophilization or the spray drying that is about original volume;
B, to squeeze the juice the back last solid residue, 40～95% ethanol soaked overnight after-filtration in 10～70 ℃ of temperature ranges with 2～4 times of volumes, collect filtrate, after will filtering the gained filtering residue again and in 10～70 ℃ of temperature ranges, soaking 4～48 hours with 40～95% ethanol of 2～4 times of volumes, filter, collect filtrate, after above-mentioned twice gained filtrate is merged, be concentrated into and be about 1/2 of original volume, through vacuum lyophilization or spray drying;
C, merge a, the dry loose freeze-dried powder of b operation gained, sealing be placed on preserve in 4～10 ℃ of dry environments standby;
D, soak Radix Notoginseng crude drug (Radix Notoginseng, the stem and leaf) 2 0～60min that pulverizes with the ordinary water of 2～3 times of weight, feeding is steam heated to about 90 ℃, and be incubated 1 hour, then, filter after cooling lixiviating solution I, the gained filtering residue adds the ordinary water of 3 times of weight again, lixiviate 40min under same condition, filter cleaner gets lixiviating solution II, and twice gained lixiviating solution merged;
E, make adsorbent with macroporous adsorbent resin, d operation gained filtrate is gone up macroporous resin column, wash with water earlier 1～3 time, continue and wash 1～2 time with 10～20% ethanol, after abandoning or adopting cleaning mixture, again with 50～70% ethanol elutions 2～3 times, collect eluent and concentrate the final vacuum lyophilization, pulverize and promptly get the Radix Notoginseng total arasaponins powder that loosens through rotary evaporation;
F, Radix Ginseng crude drug (Radix Ginseng, reed head, stem and leaf, son) is ground into the coarse granule (crossing 20 mesh sieves) of suitable granularity, measures 70% ethanol with 8 times and extract 3 hours/time altogether 2 times, merge extractive liquid,, after reclaiming ethanol,, promptly get the Radix Ginseng total saponins powder with the vacuum lyophilization of gained extractum, pulverizing;
G, with the dry Herba Apii graveolentis extract of c, e, f operation gained and Radix Notoginseng total arasaponins and/or Radix Ginseng total saponins by 80～20:20～80 weight portion mix homogeneously, encapsulate.Promptly can be used for producing health food such as dosage forms such as tablet, capsule, granule and oral liquids;
During production, can add suitable adjuvant such as an amount of Mel, sugar, starch according to the needs of different dosage form.
Embodiment:
A, get bright Herba Apii graveolentis 10kg, remove impurity, it is broken to clean the back, squeezes the juice.The bright Sucus Oenanthes Javanicae of gained is concentrated into 1/2 final vacuum lyophilization or the spray drying that is about original volume;
B, the last residue in back of squeezing the juice, 40～95% ethanol soaked overnight after-filtration under 45 ℃ of temperature with 3 times of volumes, collect filtrate, to filter again the gained filtering residue with 40～95% ethanol of 4 times of volumes after soaking 24 hours under 45 ℃ of temperature, filter, collect filtrate, after above-mentioned twice gained filtrate is merged, be concentrated into and be about 1/2 of original volume, through vacuum lyophilization or spray drying;
C, merge a, the dry loose freeze-dried powder of b operation gained, sealing be placed on preserve in 4 ℃ of dry environments standby;
D, soak Radix Notoginseng crude drug (Radix Notoginseng and/or the stem and leaf) 20min that pulverizes with the ordinary water of 3 times of weight, feeding is steam heated to about 90 ℃, and be incubated 1 hour, then, filter after cooling lixiviating solution I, the gained filtering residue adds the ordinary water of 3 times of weight again, lixiviate 40min under same condition, filter cleaner gets lixiviating solution II, and twice gained lixiviating solution merged;
E, make adsorbent with macroporous adsorbent resin, d operation gained filtrate is gone up macroporous resin column, wash with water earlier 2 times, continue and wash 1 time with 10% ethanol, after discarding cleaning mixture, again with 55% ethanol elution 3 times, collect eluent and concentrate the final vacuum lyophilization, pulverize and promptly get the Radix Notoginseng total arasaponins powder that loosens through rotary evaporation;
F, with gained Herba Apii graveolentis extract and Radix Notoginseng total arasaponins powder weight ratio mixing, again by 2% ratio adding fluidizer by 38: 62---mixing behind the microcrystalline Cellulose is filled in 2
#Capsules gets final product.
Claims (3)
1, a kind of health food with blood pressure regulation, blood lipid regulation effect is characterized in that component is: 20～80 parts of Herba Apii graveolentis extract, and 80～20 parts of Radix Notoginseng total arasaponins and/or Radix Ginseng total saponinss, the summation of final component is 100 parts.
2, according to the preparation method of the described health food of claim 1, it is characterized in that:
A, get bright Herba Apii graveolentis, roguing, it is broken to clean the back, and the bright Sucus Oenanthes Javanicae of squeezing the juice, will filter gained is concentrated into 1/2 final vacuum lyophilization or the spray drying that is about original volume;
B, to squeeze the juice the back last solid residue, 40～95% ethanol soaked overnight after-filtration in 10～70 ℃ of temperature ranges with 2～4 times of volumes, collect filtrate, after will filtering the gained filtering residue again and in 10～70 ℃ of temperature ranges, soaking 4～48 hours with 40～95% ethanol of 2～4 times of volumes, filter, collect filtrate, after above-mentioned twice gained filtrate is merged, be concentrated into and be about 1/2 of original volume, through vacuum lyophilization or spray drying;
C, merge a, the dry loose freeze-dried powder of b operation gained, sealing be placed on preserve in 4～10 ℃ of dry environments standby;
D, soak the Radix Notoginseng crude drug 20～60min that pulverizes with the ordinary water of 2～3 times of weight, feeding is steam heated to about 90 ℃, and be incubated 1 hour, then, filter after cooling lixiviating solution I, the gained filtering residue adds the ordinary water of 3 times of weight again, lixiviate 40min under same condition, filter cleaner gets lixiviating solution II, and twice gained lixiviating solution merged;
E, make adsorbent with macroporous adsorbent resin, d operation gained filtrate is gone up macroporous resin column, wash with water earlier 1～3 time, continue and wash 1～2 time with 10～20% ethanol, after abandoning or adopting cleaning mixture, again with 50～70% ethanol elutions 2～3 times, collect eluent and concentrate the final vacuum lyophilization, pulverize and promptly get the Radix Notoginseng total arasaponins powder that loosens through rotary evaporation;
F, the Radix Ginseng crude drug was ground into the coarse granule of 20 mesh sieve granularities, extracted altogether 2 times with 8 times of amount 70% ethanol, 3 hours/time, merge extractive liquid,, reclaim ethanol after, with the vacuum lyophilization of gained extractum, pulverizing, promptly get the Radix Ginseng total saponins powder;
G, the dry Herba Apii graveolentis extract of c, e, f operation gained and Radix Notoginseng total arasaponins and/or Radix Ginseng total saponins are pressed 80～20: 20～80 weight portion mix homogeneously, help again with proper auxiliary materials, make the health food of sheet, granule, capsule and peroral dosage form by the corresponding preparation requirement.
3, according to claim 1 and 2 described health foods and preparation method thereof, it is characterized in that: but Radix Notoginseng crude drug Radix Notoginseng and/or stem and leaf in the raw material made, but Radix Ginseng crude drug Radix Ginseng, reed head, stem and leaf and/or Fructus Ginseng.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455390B (en) * | 2008-11-27 | 2011-12-28 | 成都润馨堂药业有限公司 | Nutrient health-care food capable of adjusting blood pressure and preparation method thereof |
| CN102524635A (en) * | 2010-12-27 | 2012-07-04 | 程辉 | Ginseng-sweet tea extract and preparation method thereof |
| CN106722881A (en) * | 2016-12-14 | 2017-05-31 | 安徽元贞川崎食品有限公司 | Health care mushroom juice of prevention and/or improvement cardiovascular and cerebrovascular disease and preparation method thereof |
| CN114209723A (en) * | 2021-12-30 | 2022-03-22 | 辽宁上药好护士药业（集团）有限公司 | Composition for assisting in reducing blood fat, product containing composition and application |
-
2002
- 2002-01-25 CN CNB02113281XA patent/CN1150839C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455390B (en) * | 2008-11-27 | 2011-12-28 | 成都润馨堂药业有限公司 | Nutrient health-care food capable of adjusting blood pressure and preparation method thereof |
| CN102524635A (en) * | 2010-12-27 | 2012-07-04 | 程辉 | Ginseng-sweet tea extract and preparation method thereof |
| CN106722881A (en) * | 2016-12-14 | 2017-05-31 | 安徽元贞川崎食品有限公司 | Health care mushroom juice of prevention and/or improvement cardiovascular and cerebrovascular disease and preparation method thereof |
| CN106722881B (en) * | 2016-12-14 | 2021-06-22 | 上海天天商务实业有限公司 | Health-care mushroom juice for preventing and/or improving cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN114209723A (en) * | 2021-12-30 | 2022-03-22 | 辽宁上药好护士药业（集团）有限公司 | Composition for assisting in reducing blood fat, product containing composition and application |
| CN114209723B (en) * | 2021-12-30 | 2023-10-03 | 辽宁上药好护士药业（集团）有限公司 | Composition for assisting in reducing blood fat, product containing composition and application |
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| Publication number | Publication date |
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| CN1150839C (en) | 2004-05-26 |
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