CN108837036A - A kind of blood fat-reducing blood pressure-decreasing, the preparation for preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof - Google Patents
A kind of blood fat-reducing blood pressure-decreasing, the preparation for preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof Download PDFInfo
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Abstract
A kind of blood fat-reducing blood pressure-decreasing, the preparation for preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof, its use 10 parts~30 parts of alga oligosaccharides, 50~100 parts of Radix Salviae Miltiorrhizae part, 50 parts~100 parts of fructus lycii, 50 parts~100 parts of pueraria lobata, 3 parts~10 parts of Radix Notoginseng, 30 parts~80 parts of hawthorn, 30 parts~80 parts of dried orange peel, 30 parts~80 parts of chrysanthemum, 30 parts~80 parts of mulberry leaf, 10 parts~30 parts of red kojic rice powder capsule, tablet, granule is made through the techniques such as crushing, extraction, concentration, drying, mixing, filling, the beneficial effects of the invention are as follows：It is combined using traditional Chinese herbal medicine with alga oligosaccharides, all multicomponent mutual reinforcements between mutually make, and keep the present invention significant in efficacy, the symptoms such as dizziness, headache, out of strength, palpitaition, shortness of breath, insomnia, agitation caused by being suitable for because of hypertension, hyperlipidemia, cardiovascular and cerebrovascular disease.
Description
Technical field
The present invention relates to marine product and the field of Chinese medicines, specifically a kind of preparation can be used for blood fat-reducing blood pressure-decreasing, the prevention and treatment heart
Cranial vascular disease.
Background technique
With the development of the social economy, the change of people life style, cerebrovascular disease incidence of disease increase year by year, at present
Global incidence, the death rate all account for the firsts.Due to the eating habit of people, office habit etc., obese people is more and more, in turn
A series of metabolic diseases such as hypertension, diabetes, hyperlipidemia also increase therewith, and these diseases are all cardiovascular and cerebrovascular diseases
Risk factor, it is various for the product category of lowering blood pressure and blood fat etc. on the market at present, but rarer product use seaweed and
Its product.
Seaweed industry is the important component of China's marine economy, and the industry scale of construction is huge, and the main component of seaweed is yes
Seaweed glue, seaweed glue is mainly used in the fields such as food additives, thickener and industrial chemicals at present, and added value of product is low.Closely
Several years advanced biological enzymolysis technologies are applied in seaweed deep processing industry, and product gets rid of " iodine, alcohol, glue " old three sample, energy
A variety of alga oligosaccharides with physiological activity are enough prepared, have the characteristics that efficient, environmental protection and product are single-minded, the present invention lives height
Property alga oligosaccharides apply to the health that health industry is not only advantageous for the mankind, also help the upgrading of seaweed industry.
Summary of the invention
The present invention provides a kind of blood fat-reducing blood pressure-decreasing, the preparation for preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof, extends seaweed
The application range of oligosaccharides, and significant effect, it is convenient to take.
The technical solution adopted by the present invention to solve the technical problems is：A kind of blood fat-reducing blood pressure-decreasing, prevention and treatment cardiovascular and cerebrovascular disease
Preparation and preparation method thereof, use alga oligosaccharides, Radix Salviae Miltiorrhizae, fructus lycii, pueraria lobata, Radix Notoginseng, hawthorn, dried orange peel, chrysanthemum, mulberry leaf,
Red kojic rice powder is raw material, is by following quality proportionings：10 parts~30 parts of alga oligosaccharides, 50~100 parts of Radix Salviae Miltiorrhizae part, 50 parts of fructus lycii
~100 parts, 50 parts~100 parts of pueraria lobata, 3 parts~10 parts of Radix Notoginseng, 30 parts~80 parts of hawthorn, 30 parts~80 parts, 30 parts of chrysanthemum of dried orange peel
~80 parts, 30 parts~80 parts of mulberry leaf, 10 parts~30 parts of red kojic rice powder through the techniques such as crushing, extraction, concentration, drying, mixing, filling
Capsule, tablet, granule is made.Its specific preparation process is：80 DEG C of Radix Notoginseng drying, crushing are sieved with 100 mesh sieve；By Radix Salviae Miltiorrhizae,
Pueraria lobata, hawthorn, dried orange peel, chrysanthemum, mulberry leaf are ground into coarse powder, are put into extractor, are extracted 2 times with 75% alcohol reflux, for the first time
Add 5 times of amount solvent extraction 2h, second plus 4 times of amount solvent extraction 1h, merges filtrate twice, under conditions of 0.08MPa, 65 DEG C
Ethyl alcohol is recovered under reduced pressure, and solution is concentrated into the medicinal extract that relative density is 1.10~1.30, it is spare；By fructus lycii and the above-mentioned dregs of a decoction
It adds water to cook 2 times, for the first time plus 10 times of amount decocting 2h, second plus 8 times of amount decocting 1h, merging filtrate twice, in 0.08MPa,
The medicinal extract that relative density is 1.20~1.30 is concentrated under reduced pressure under conditions of 75 DEG C；By alcohol-extracted extract, the water extracted immersing paste, Radix Notoginseng fine powder
Mix, be dried under reduced pressure under conditions of 0.075~0.085MPa, 60 DEG C, be ground into 100 mesh fine powders, then with alga oligosaccharides,
Red kojic rice powder is uniformly mixed, and capsule, tablet or granule is made through capsule charge, tabletting or granule packaging.
Part of the present invention is mass parts, is the mass units such as microgram commonly used in the art, milligram, gram, kilogram.
It is fermented obtained that alga oligosaccharides of the present invention can be brown alga, red algae, cyanobacteria, green alga.
It is 2~4g, in two times, one after each meal that invention formulation suggestion, which takes daily effective quantity,.
The beneficial effects of the invention are as follows：The present invention is combined using traditional Chinese herbal medicine with alga oligosaccharides, and wherein seaweed is few
Sugar can prevent the formation of hypercholesterolemia, have the cardiovascular normal function of lipid-loweringing, maintenance；Contained by fructus lycii, pueraria lobata
Effect ingredient can reduce the content of serum total cholesterol, the generation of atherosclerosis；Radix Salviae Miltiorrhizae, hawthorn, chrysanthemum can be expanded
Coronary artery increases coronary flow, has obvious protective function to myocardial damage caused by acute myocardial ischemia anoxic；Radix Notoginseng,
Dried orange peel can soften blood vessel, promote blood health；Mulberry leaf, red kojic rice powder equally also have effects that reducing blood lipid, blood pressure lowering, Zhu Duocheng
Split-phase must, mutually make, and keep the present invention significant in efficacy, dizzy, head caused by being suitable for because of hypertension, hyperlipidemia, cardiovascular and cerebrovascular disease
Bitterly, the symptoms such as out of strength, palpitaition, shortness of breath, insomnia, agitation.
The function of invention formulation.
1, reducing blood lipid, blood pressure lowering
Flavone compound contained in the present invention can reduce the content of serum total cholesterol, reduce triglycerides, reduce
The content of low-density lipoprotein, the content of increasing high density lipoprotein, to have the function that reducing blood lipid, blood pressure lowering.
2, improve blood circulation, prevention and treatment cardiovascular and cerebrovascular disease
Multiple components in preparation have coronary artery dilator, increase coronary blood flow, reduce myocardial excitability and conductibility, right
Myocardial damage caused by acute myocardial ischemia anoxic has obvious protective function, inhibits coronary atherosclerosis to be formed, can effectively prevent
Control cardiovascular and cerebrovascular disease.
3, immunity of organisms is improved
The Multiple components such as oligosaccharides, polysaccharide in preparation can promote the growth of lymphocyte, enhance the phagocytic function of macrophage,
To improve the immune function of body, enhance the immunity of human body.
Compound basis.
Alga oligosaccharides have the effects that whole intestines and removing toxic substances, reducing blood sugar and blood lipid, anticoagulation, anti-inflammatory, immunological regulation, can be used as sugar
Urinate disease, obesity, carcinoma of the colon and rectum, habitual constipation patient remedy diet.The algin oligosaccharide of suitable dose can be preferably
The formation for preventing hypercholesterolemia plays the role of lipid-loweringing, safeguards cardiovascular normal function.
Radix Salviae Miltiorrhizae, it is bitter, pungent；It is cool in nature.With activating microcirculation and removing stasis medicinal, the effect of cool blood to disappear carbuncle, nourishing blood and tranquilization.Contain Radix Salviae Miltiorrhizae in Radix Salviae Miltiorrhizae
Ketone compounds and phenolic acid compound, modern pharmacological studies have shown that Radix Salviae Miltiorrhizae energy coronary artery dilator, can increase coronary flow,
Myocardial excitability and conductibility are reduced, there is obvious protective function to myocardial damage caused by acute myocardial ischemia anoxic, simultaneously
It can reduce blood lipid, coronary atherosclerosis inhibited to be formed.Radix Salviae Miltiorrhizae also has improvement microcirculation, antiplatelet aggregation and thrombus shape
At, and blood viscosity can be made to decline, these effects are conducive to improve blood circulation, beneficial to the protection of myocardial ischemic injury.
Fructus lycii main active has polysaccharides, glycine betaine, wolfberry pigment etc., and modern pharmacology research confirms fructus lycii
Son, which has, to be adjusted body's immunity, inhibits tumour growth and cell mutation, anti-aging, anti-fatty liver, adjusts blood lipid and blood
Sugar promotes the effects of hematopoiesis function.Wherein superoxide dismutase in damaged islet cells (SOD) can be remarkably reinforced in polysaccharides
Activity, improve the oxidation resistance of islet cells, mitigate damage of the peroxide to cell, reduce in dialdehyde production quantity, this
Show that polysaccharides has certain protective effect to islet cells.Serum cholesterol and trigalloyl can be significantly reduced in edible fructus lycii
The content of glycerol mitigates and prevents artery sclerosis, treats hypertension.Glycine betaine has certain work to lipid-metabolism and anti-fatty liver
With.Wolfberry pigment has the effects that improve immune function of human body, prevention and inhibits tumour and prevention of arterial atherosis.
Pueraria lobata, pueraria lobata main chemical compositions have Pueraria Flavonid, Puerarin, pueraria lobata daidzein, wherein Pueraria Flavonid
Plasma renin activity and angiotensins can be made to significantly reduce with Puerarin, blood pressure decline.Pueraria Flavonid has obvious expansion
Cerebrovascular effect improves brain microcirculation and peripheral circulation.Pueraria lobata daidzein can improve symptoms of cerebral ischemia.Puerarin can expand
The cerebrovascular is opened, cerebral blood flow (CBF) is increased, improves vertebrobasilar insufficiency etc., Puerarin can also be substantially reduced serum total cholesterol
Content, the content of increasing high density lipoprotein reduces low-density lipoprotein and very low density lipoprotein content, prevents low-density
Lipoprotein excessive oxidation reaches reduction fat in coronary artery than depositing, reduces the effect of the incidence of atherosclerosis.
Radix Notoginseng, warm-natured, sweet in flavor, slight bitter returns liver stomach meridian.Radix Notoginseng has effects that promoting blood circulation to remove blood stasis, energy platelet aggregation-against, anti-blood
Bolt is formed.Have effects that activating microcirculation and removing stasis medicinal, long-term use can soften blood vessel simultaneously, have good effect to promotion blood health,
It can prevent a variety of heart and brain blood diseases.
Hawthorn, sour, sweet, slightly warm in nature；Returns spleen, stomach, Liver Channel.Hawthorn can change turbid lipid-loweringing, and contained fatty acid can
Promote fat digestion, can reducing blood lipid, antiatherosclerosis, it is modern hawthorn often is applied alone treat hyperlipidemia and coronary heart disease,
High blood pressure etc.；Haw thorn extract has coronary artery dilator, increases coronary blood flow, protects the cardiac muscle of hypoxic-ischemic, and can be strong
The heart, blood pressure lowering and confrontation arrhythmia cordis；The excretion of Blood Cholesterol can be increased again simultaneously and reducing blood lipid, therefore hawthorn has very
Good protectiveness heart and cardiovascular effect.
Dried orange peel, it is warm-natured；It is pungent, bitter；Returns spleen, lung channel.With strengthening the spleen and stomach, the effect of ventilating, lowering the adverse-rising QI and eliminating phlegm.It is old simultaneously
Skin decoction, ethanol extract can be excited myocardium, and dosage should not be too large.Reasonably edible dried orange peel can make blood vessel light contraction,
Increase blood pressure, the patient suitable for low blood pressure.The lipid peroxy of aurantiamarin in dried orange peel to myocardial infections and arteriosclerotic
Change is formed with inhibiting effect.Contain a lower-molecular substance in orange pectin, has the function of reducing blood lipid.Chrysanthemum, property is sweet, it is bitter,
It is slightly cold, return lung, Liver Channel.The study found that chrysanthemum energy is calm, decompression, coronary artery dilator increases coronary blood flow, for a long time
It drinks and is adjustable myocardial function, reduces cholesterol, to coronary heart disease, hypertension, the excessively high disease of artery sclerosis, serum cholesterol has very
Good curative effect.
Mulberry leaf, it is cold in nature, it is sweet in flavor, bitter, enter liver, lung channel.Currently, researcher is to the composition of mulberry leaf, function and mechanism of action
Systematic research has been carried out, has found amino acid, food fiber, vitamin, minerals and a variety of lifes rich in mulberry leaf
Active material is managed, there are the various health care functions such as hypoglycemic, lowering blood pressure and blood fat, anti-aging.
Red kojic rice powder is process by early rice is fermented, and pharmacologist has found in recent years, and red yeast rice is used as medicine, and is a kind of outstanding
Reducing blood lipid, blood pressure lowering natural drug.In the monumental work of Li Shizhen (1518-1593 A.D.) chief editor《Herbal guiding principle monascus Zoopagales》It has been recorded in one book several
A good recipe of curing the disease containing red yeast rice ingredient.
Specific embodiment
The present invention will be further described with reference to the examples below.
Embodiment 1：A kind of blood fat-reducing blood pressure-decreasing, the preparation for preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof use seaweed few
Sugared 20 parts, 80 parts of Radix Salviae Miltiorrhizae part, 80 parts of fructus lycii, 80 parts of pueraria lobata, 8 parts of Radix Notoginseng, 50 parts of hawthorn, 50 parts of dried orange peel, 50 parts of chrysanthemum, mulberry leaf
50 parts, 20 parts of red kojic rice powder, preparation process are：80 DEG C of Radix Notoginseng drying, crushing are sieved with 100 mesh sieve；By Radix Salviae Miltiorrhizae, pueraria lobata, hawthorn, old
Skin, chrysanthemum, mulberry leaf are ground into coarse powder, are put into extractor, are extracted 2 times with 75% alcohol reflux, add 5 times of amount solvents for the first time
2h is extracted, second plus 4 times of amount solvent extraction 1h, merges filtrate twice, second is recovered under reduced pressure under conditions of 0.08MPa, 65 DEG C
Alcohol, and solution is concentrated into the medicinal extract that relative density is 1.10~1.30, it is spare；Fructus lycii and the above-mentioned dregs of a decoction are added water to cook 2
It is secondary, add 10 times of amount decocting 2h for the first time, second plus 8 times of amount decocting 1h, merges filtrate twice, in 0.08MPa, 75 DEG C of condition
Under be concentrated under reduced pressure into relative density be 1.20~1.30 medicinal extract；Alcohol-extracted extract, the water extracted immersing paste, Radix Notoginseng fine powder are mixed,
0.075~0.085MPa is dried under reduced pressure under conditions of 60 DEG C, was ground into 100 mesh fine powders, then with alga oligosaccharides, red yeast rice
Powder is uniformly mixed, and capsule is made through capsule charge.Daily 2~4g divides 2 times and takes.
Embodiment 2：A kind of blood fat-reducing blood pressure-decreasing, the preparation for preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof use seaweed few
Sugared 30 parts, 50 parts of Radix Salviae Miltiorrhizae part, 100 parts of fructus lycii, 100 parts of pueraria lobata, 5 parts of Radix Notoginseng, 30 parts of hawthorn, 80 parts of dried orange peel, 30 parts of chrysanthemum, mulberry
80 parts of leaf, 10 parts of red kojic rice powder, specific preparation process are：80 DEG C of Radix Notoginseng drying, crushing are sieved with 100 mesh sieve；By Radix Salviae Miltiorrhizae, pueraria lobata,
Hawthorn, dried orange peel, chrysanthemum, mulberry leaf are ground into coarse powder, are put into extractor, are extracted 2 times with 75% alcohol reflux, add 5 times for the first time
Solvent extraction 2h is measured, second plus 4 times of amount solvent extraction 1h, merges filtrate twice, is depressurized under conditions of 0.08MPa, 65 DEG C
Ethyl alcohol is recycled, and solution is concentrated into the medicinal extract that relative density is 1.10~1.30, it is spare；Fructus lycii and the above-mentioned dregs of a decoction are added into water
It decocts 2 times, for the first time plus 10 times of amount decocting 2h, second plus 8 times of amount decocting 1h, merging filtrate twice, in 0.08MPa, 75 DEG C
Under conditions of be concentrated under reduced pressure into relative density be 1.20~1.30 medicinal extract；Alcohol-extracted extract, the water extracted immersing paste, Radix Notoginseng fine powder are mixed
It is even, be dried under reduced pressure under conditions of 0.075~0.085MPa, 60 DEG C, be ground into 100 mesh fine powders, then with alga oligosaccharides, red
Bent rice flour is uniformly mixed, and tablet is made through tabletting.Daily 2~4g divides 2 times and takes.
Embodiment 3：A kind of blood fat-reducing blood pressure-decreasing, the preparation for preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof use seaweed few
Sugar 10 parts, 100 parts of Radix Salviae Miltiorrhizae part, 50 parts of parts of fructus lycii, 70 parts of pueraria lobata, 10 parts of Radix Notoginseng, 80 parts of hawthorn, 30 parts of dried orange peel, 80 parts of chrysanthemum,
30 parts of mulberry leaf, 30 parts of red kojic rice powder, specific preparation process are：80 DEG C of Radix Notoginseng drying, crushing are sieved with 100 mesh sieve；By Radix Salviae Miltiorrhizae, Pueraria lobota
Root, hawthorn, dried orange peel, chrysanthemum, mulberry leaf are ground into coarse powder, are put into extractor, are extracted 2 times with 75% alcohol reflux, are added for the first time
5 times of amount solvent extraction 2h second plus 4 times of amount solvent extraction 1h, merge filtrate twice, subtract under conditions of 0.08MPa, 65 DEG C
Receipts ethyl alcohol is pushed back, and solution is concentrated into the medicinal extract that relative density is 1.10~1.30, it is spare；Fructus lycii and the above-mentioned dregs of a decoction are added
Water decocts 2 times, for the first time plus 10 times of amount decocting 2h, second plus 8 times of amount decocting 1h, merging filtrate twice, in 0.08MPa, 75
The medicinal extract that relative density is 1.20~1.30 is concentrated under reduced pressure under conditions of DEG C；Alcohol-extracted extract, the water extracted immersing paste, Radix Notoginseng fine powder are mixed
It is even, be dried under reduced pressure under conditions of 0.075~0.085MPa, 60 DEG C, be ground into 100 mesh fine powders, then with alga oligosaccharides, red
Bent rice flour is uniformly mixed, and granule is made through granule packaging.Daily 2~4g divides 2 times and takes.
Embodiment 4：Using manufactured invention formulation in embodiment 1, function of the invention is verified.
1. material.
1.1 sample：
Capsule of the present invention, human body recommended amounts 3g/60kg BW, is equivalent to 50mg/kg BW, room temperature preservation is for experiment.
1.2 experimental method：
Male Wistar rat 50 of health, weight（200±20）G, after adaptable fed 1 week, weighing takes blood on an empty stomach.
Measure serum total cholesterol（TC）, triglycerides（TG）And high-density lipoprotein cholesterol（HDL-C）Level, according to weight and TC
Level is randomly divided into 5 groups, and every group 10, respectively invention formulation 1.2g/kg BW, 0.8g/kg BW, 0.4g/kg BW
High, medium and low three dosage groups, model control group and blank control group.After experiment starts, blank control group is fed with basal feed
It supports, remaining each group is fed with high lipid food（80% basal feed, 1% cholesterol, 10% yolk powder, 10% lard）, give at regular time and quantity
Food and drinking-water, while the oral stomach-filling of each rats in test groups is given by test preparation, starch 0.8g/kg is given in two control group stomach-fillings,
Continuous to feed 30d, weight of weighing weekly is primary,.Blood sampling measurement serum TC, TG and HDL-C contain after fasting 16h when test to terminal
Amount.
2 results
Influence of 2.1 invention formulations to rat body weight
Influence of 1 invention formulation of table to rat body weight（±SD）
Note：There are no significant for comparing difference between each group in table（P > 0.05）.
Seen from table 1, rat original body mass is in each dosage group and control group comparison among groups, and there are no significant for difference（P >
0.05）, i.e. the original body mass of rat more equilibrium between each group.The invention formulation 30d of orally administration rat various dose, eventually
Weight is in its corresponding control group comparison among groups of each dosage group, and there are no significant for difference（P > 0.05）, i.e. invention formulation pair
Rat body weight increases without influence.
2.2 tested rats are initial and terminal TC, TG and HDL-C content
The tested rat of table 2 is initial and terminal TC, TG and HDL-C content（±SD）
Note：* it indicates and model control group is poor different has conspicuousness（P < 0.05）.
As can be seen from Table 2, each group TC, TG and HDL-C content is almost the same when on-test.Test terminal model control group
The content of TC, TG are apparently higher than Basal control group and three dosage groups, and difference has conspicuousness（P < 0.05）, terminal model pair
Basal control group and three dosage groups are significantly lower than according to the content of group HDL-C, difference has conspicuousness（P < 0.05）, show this
Invention preparation can reduce rat blood serum total cholesterol and triglycerides, increase rat blood serum high-density lipoprotein cholesterol, institute
Have the function of blood fat-reducing blood pressure-decreasing, prevention and treatment cardiovascular and cerebrovascular disease with invention formulation.
Above-mentioned technical proposal only embodies the optimal technical scheme of technical solution of the present invention, those skilled in the art
The principle of the present invention is embodied to some variations that some of them part may make, belongs to the range of protection of the invention.
Claims (3)
1. a kind of blood fat-reducing blood pressure-decreasing, the preparation for preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof, use alga oligosaccharides, Radix Salviae Miltiorrhizae, Chinese holly
Matrimony vine, pueraria lobata, Radix Notoginseng, hawthorn, dried orange peel, chrysanthemum, mulberry leaf, red kojic rice powder are raw material, are by following quality proportionings：Alga oligosaccharides 10
Part~30 parts, 50~100 parts of Radix Salviae Miltiorrhizae part, 50 parts~100 parts of fructus lycii, 50 parts~100 parts of pueraria lobata, 3 parts of Radix Notoginseng~10 parts, hawthorn
30 parts~80 parts, 30 parts~80 parts of dried orange peel, 30 parts~80 parts of chrysanthemum, 30 parts~80 parts of mulberry leaf, 10 parts~30 parts of red kojic rice powder warps
Capsule, tablet, granule is made in the techniques such as crushing, extraction, concentration, dry, mixing, filling.
2. a kind of blood fat-reducing blood pressure-decreasing according to claim 1, the preparation for preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof, tool
Preparation process is：80 DEG C of Radix Notoginseng drying, crushing are sieved with 100 mesh sieve；Radix Salviae Miltiorrhizae, pueraria lobata, hawthorn, dried orange peel, chrysanthemum, mulberry leaf are crushed
It at coarse powder, is put into extractor, is extracted 2 times with 75% alcohol reflux, add 5 times of amount solvent extraction 2h for the first time, add 4 for the second time
Amount solvent extraction 1h again merges filtrate twice, ethyl alcohol is recovered under reduced pressure under conditions of 0.08MPa, 65 DEG C, and solution is concentrated into
The medicinal extract that relative density is 1.10~1.30, it is spare；Fructus lycii and the above-mentioned dregs of a decoction are added water to cook 2 times, add 10 times of water for the first time
Decocting 2h is measured, second plus 8 times of amount decocting 1h, merges filtrate twice, is concentrated under reduced pressure into phase under conditions of 0.08MPa, 75 DEG C
The medicinal extract for being 1.20~1.30 to density；Alcohol-extracted extract, the water extracted immersing paste, Radix Notoginseng fine powder are mixed, in 0.075~0.085MPa,
It is dried under reduced pressure under conditions of 60 DEG C, was ground into 100 mesh fine powders, and was then uniformly mixed with alga oligosaccharides, red kojic rice powder, through capsule
Capsule, tablet or granule is made in filling, tabletting or granule packaging.
3. a kind of blood fat-reducing blood pressure-decreasing according to claim 1, the preparation for preventing and treating cardiovascular and cerebrovascular disease and preparation method thereof, special
It is fermented obtained that point is that the alga oligosaccharides can be brown alga, red algae, cyanobacteria, green alga.
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