CN114223895A - Food formula for preventing and treating hyperlipidemia - Google Patents
Food formula for preventing and treating hyperlipidemia Download PDFInfo
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Abstract
A food formula for preventing and treating hyperlipemia relates to the technical field of cardiovascular and cerebrovascular diseases, and comprises the following components: compared with the existing western medicines and traditional Chinese medicine treatment, the food formula of the invention is used as a medicine-food homologous traditional Chinese medicine under a proper amount of conditions, takes the main aim of monarch, minister, assistant and guide of the traditional Chinese medicine, and after the food formula is taken by a human body, the food formula is non-toxic and harmless, and through the synergistic interaction between the traditional Chinese medicines, the food formula can prevent hyperlipidemia diseases for normal people, has the effects of reducing blood fat, dredging blood vessels, relieving atherosclerosis, protecting liver and benefiting gallbladder, particularly reducing low-density lipoprotein cholesterol, and has the effects of aging resistance and the like.
Description
Technical Field
The invention relates to the technical field of cardiovascular and cerebrovascular diseases, in particular to a food formula for preventing and treating hyperlipidemia.
Background
Cardiovascular and cerebrovascular diseases are the general names of cardiovascular and cerebrovascular diseases, and generally refer to ischemic or hemorrhagic diseases of heart, brain and systemic tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension and the like. The cardiovascular and cerebrovascular diseases are common diseases seriously threatening the health of human beings, particularly the middle-aged and old people over 50 years old, have the characteristics of high morbidity, high disability rate and high mortality, even if the most advanced and perfect treatment means at present are applied, more than 50 percent of cerebrovascular accident survivors can not completely take care of the life, the number of people dying from the cardiovascular and cerebrovascular diseases in each year in the world reaches 1500 thousands, and the people live at the first of various causes of death. 200 million of the new stroke patients in China are annually killed or disabled by 2/3, and the total number of the existing stroke patients is 700 million.
Atherosclerosis is the pathological basis of cardiovascular and cerebrovascular diseases such as coronary heart disease, myocardial infarction, cerebral infarction, limb vascular occlusion and the like. The atherosclerosis can cause the blockage of arterial blood vessels of all parts of the body, the coronary artery blockage on the heart can cause coronary heart disease, the complete blockage of the blood vessels can cause myocardial infarction, the blockage of cerebral arteries can cause cerebral infarction and senile dementia, and the blockage of limb arteries can cause limb ischemia and necrosis.
The heart of atherosclerosis is dyslipidemia, and non-drug modes such as life style adjustment, diet adjustment and the like and lipid-lowering drugs are mainly adopted for hyperlipidemia at home and abroad. In the aspect of Western medicine lipid lowering, the most clinically applied representative medicine types are statins for regulating blood lipid, such as simvastatin, unsaturated fatty acids, fibrates, such as fenofibrate and the like. Although the treatment effect of the drug treatment is definite, the drug treatment has potential risks to human bodies along with the increase of the dosage or the prolonging of the administration time. Moreover, the incidence of hyperlipidemia increases year by year, and patients also show a trend of getting younger and younger, so that the development of health-care food for preventing and treating and regulating blood lipid is necessary, the concept of Chinese traditional medicine is fully fused, and the large health concept of converting 'treatment' into 'prevention of disease' is realized.
However, in traditional Chinese medicine, "homology of medicine and food", medicine and food refers to medicines and food with health-preserving and health-care effects, and in practical application, many medicines and food are inseparable, so that a food formula for preventing and treating hyperlipidemia is urgently needed to be provided aiming at the cardiovascular and cerebrovascular diseases.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a food formula for preventing and treating hyperlipidemia, and the specific scheme is as follows:
a food formula for preventing and treating hyperlipidemia comprises the following components:
and (3) kudingcha: 1-5 parts by weight
Honeysuckle flower: 1-3 parts by weight
Wild jujube seed: 5-8 parts by weight
Cassia seed: 1-5 parts by weight
Gardenia: 1-5 parts by weight
Dandelion: 1-5 parts by weight
Medlar: 5-10 parts by weight
Kudzu root: 1-5 parts by weight
Chrysanthemum: 1-3 parts by weight of hawthorn: 5-10 parts by weight
Lotus leaf: 5-10 parts by weight
Turmeric: 1-3 parts by weight
Red yeast rice: 1-3 parts by weight.
Further, the content of each component in the food formula is preferably as follows: and (3) kudingcha: 3 parts by weight of
Honeysuckle flower: 2 parts by weight of
Wild jujube seed: 6.5 parts by weight
Cassia seed: 3 parts by weight of
Gardenia: 3 parts by weight of
Dandelion: 3 parts by weight of
Medlar: 7.5 parts by weight
Kudzu root: 3 parts by weight of
Chrysanthemum: 2 parts by weight of hawthorn: 7.5 parts by weight
Lotus leaf: 7.5 parts by weight
Turmeric: 2 parts by weight of
Red yeast rice: 2 parts by weight.
Further, the production process of the food formula comprises the steps of adding a plurality of different components into water or ethanol-water solution together, extracting for a certain time under set conditions to obtain different extracting solutions, concentrating and evaporating the extracting solutions respectively to obtain different extractum, mixing the extractum, and automatically granulating.
Further, the production process of the food formula comprises the following specific steps:
adding 50 times of 70% ethanol-water solution into folium Ilicis, flos Lonicerae and semen Ziziphi Spinosae, extracting for 3 times (20 min each time) under ultrasonic power of 100W and leaching temperature of 60 deg.C, mixing the three extractive solutions, recovering ethanol until there is no ethanol, and concentrating and evaporating to obtain extract I;
adding semen Cassiae, fructus Gardeniae, herba Taraxaci and fructus Lycii into 28 times of 70% ethanol-water solution, heating and reflux-extracting for 3 times, each time for 2 hr, mixing the three extractive solutions, recovering ethanol until no ethanol exists, and concentrating and evaporating to obtain extract II;
extracting radix Puerariae and fructus crataegi with 80% ethanol-water solution for 2 times, extracting with 12 times of 80% ethanol-water solution for 1 hr, extracting with 10 times of 80% ethanol-water solution for 30min, mixing the extractive solutions, recovering ethanol, and concentrating to remove water to obtain extract III;
adding 20 times of water into the chrysanthemum, the lotus leaves and the turmeric, soaking for 60min, decocting twice, 2 hours for the first time and 1 hour for the second time, combining the decoctions, filtering and drying to obtain an extract IV;
adding 10 times of 60% ethanol-water solution into red rice, extracting at 50 deg.C for 120min twice, recovering ethanol until no ethanol exists, and concentrating and evaporating water to obtain extract V;
mixing the above five extracts, adding soluble starch as binder, placing into rotary dry granulating machine, and directly granulating to obtain edible food granule.
Compared with the prior art, the invention has the following beneficial effects:
(1) the clinical use of the traditional Chinese medicines is particular to monarch, minister, assistant and guide, a single traditional Chinese medicine is difficult to exert an ideal curative effect, the food formula is prepared from multiple traditional Chinese medicines, and compared with the existing western medicines and traditional Chinese medicine treatment, the traditional Chinese medicine serving as a medicine-food homologous source in the food formula is non-toxic and harmless after being taken by a human body under a proper amount of conditions, and by virtue of the synergistic interaction among the traditional Chinese medicines, after a product prepared by the food formula is taken by the human body for a long time, the food formula not only can prevent hyperlipidemia for normal people, but also has the effects of reducing blood fat, dredging blood vessels, relieving atherosclerosis, protecting liver and benefiting gallbladder, particularly reducing low-density lipoprotein cholesterol, and also has the effects of resisting aging and the like.
Specifically, the broadleaf holly leaf, the honeysuckle, the cassia seed, the dandelion, the radix puerariae, the chrysanthemum, the lotus and the red yeast rice play a synergistic effect in the aspects of reducing blood fat, reducing blood sugar and the like, and play a role in preventing the hyperlipidaemia of patients or regulating the size of each index of the hyperlipidaemia patients together. The spina date seed, the hawthorn and the lotus have a synergistic effect on relieving arteriosclerosis, and can prevent arterial vessel blockage of various parts of the whole body or relieve arterial vessel blockage of an atherosclerosis patient. The gardenia and the turmeric have a synergistic effect in the aspect of cardiovascular and cerebrovascular protection, and have the effect of preventing diseases such as coronary heart disease, myocardial infarction, cerebral infarction and the like on a human body or relieving cardiovascular and cerebrovascular dredging on patients with the diseases. In addition, the broadleaf holly leaf, the honeysuckle, the spina date seed, the cassia seed, the gardenia, the dandelion, the medlar, the radix puerariae, the chrysanthemum, the hawthorn, the turmeric, the lotus leaf and the red yeast rice can be synergistically enhanced in oxidation resistance and aging resistance, so that the health care tea can promote the metabolism of a human body, can remove freckles, beautify and delay aging.
(2) The effective components in the traditional Chinese medicine components are extracted by different extraction methods for different traditional Chinese medicine components, and the purity and the yield of the required traditional Chinese medicine components are greatly improved by setting different extraction methods, temperatures, time and times for each time according to the characteristics of the different traditional Chinese medicine components.
(3) The five extract extracts are mixed and granulated, so that the five extract extracts are convenient to store, can be prepared into different specifications, are suitable for people with different disease degrees to take, are convenient to eat, and can be quantitatively taken.
Drawings
Figure 1 is a graph showing the effect of three groups of animals tested;
FIG. 2 is a graph showing the effect of the change in body weight, liver weight and epididymal fatty liver weight of three groups of animals;
FIG. 3 is a graph showing the effect of the changes in cholesterol level, triglyceride level, free fatty acid level, serum glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase of three groups of animals;
FIG. 4 is a graph showing the effect of serum total cholesterol, triglycerides, fasting plasma glucose, fasting insulin, and changes in insulin resistance in three groups of animals;
FIG. 5 is a graph of data relating to triglyceride changes before and after treatment;
FIG. 6 is a graph of data relating to the changes in HDL before and after treatment;
FIG. 7 is a graph of data relating to the change in LDL before and after treatment;
FIG. 8 is a graph of data relating to total cholesterol changes before and after treatment;
FIG. 9 is a graph of data relating to the change in glutamate pyruvate transaminase before and after treatment;
FIG. 10 is a graph of data relating to the changes in aspartate aminotransferase before and after treatment;
FIG. 11 is a graph of data on the change in y-glutamyl transpeptidase before and after treatment.
Detailed Description
The present invention will be described in further detail with reference to examples and drawings, but the present invention is not limited to these examples.
A food formula for preventing and treating hyperlipidemia comprises the following components:
and (3) kudingcha: 1-5 parts by weight
Honeysuckle flower: 1-3 parts by weight
Wild jujube seed: 5-8 parts by weight
Cassia seed: 1-5 parts by weight
Gardenia: 1-5 parts by weight
Dandelion: 1-5 parts by weight
Medlar: 5-10 parts by weight
Kudzu root: 1-5 parts by weight
Chrysanthemum: 1-3 parts by weight
Hawthorn fruit: 5-10 parts by weight
Lotus leaf: 5-10 parts by weight
Turmeric: 1-3 parts by weight
Red yeast rice: 1-3 parts by weight.
The broadleaf holly leaf is bitter in taste, mild in nature and non-toxic, belongs to liver, lung and stomach channels, and has the effects of reducing blood pressure, blood fat and blood sugar, losing weight, resisting oxidation, tumors and inflammation, regulating intestinal microecology, dredging heart and cerebral vessels and improving human immunity;
the honeysuckle flower is sweet in taste and cold in nature, enters lung and stomach channels, and has the effects of reducing blood fat, protecting liver and gallbladder, resisting tumor, oxidation, inflammation and virus, regulating immunity, preventing and treating senile dementia and the like. The luteolin contained in the honeysuckle can reach the deep part of the cortex, inhibit the activity of hyaluronidase, inhibit and eliminate the formation of skin color spots, and has the effects of removing freckles and beautifying;
the spina date seed is sweet and sour in taste and neutral in nature, enters heart and liver meridians, has the effects of nourishing liver, calming heart, refreshing brain, arresting sweating, quenching thirst, regulating blood pressure and blood fat of a human body, reducing serum cholesterol, improving high-density lipoprotein cholesterol, and inhibiting the formation and development of arteriosclerosis; the spina date seed also has the effects of calming and hypnotizing, and can relieve depression and anxiety and has certain curative effect on climacteric syndrome. The spina date seed can also promote blood circulation and tissue growth, stretch the facial skin, reduce wrinkles and increase the luster; the flavone contained in the spina date seed can remove free radicals, improve the immunity and resist aging;
the cassia seed is sweet, bitter and salty in taste and slightly cold in nature, and enters liver and large intestine channels, and has various effects of losing weight, reducing blood fat, reducing blood sugar, softening blood vessels, protecting liver, improving eyesight, improving sleep, relaxing bowels, beautifying, removing freckles, improving immunity, resisting bacteria, resisting inflammation, resisting cancer, protecting nerves and the like;
gardenia is bitter in taste and cold in nature, enters heart, lung and triple energizer meridians, and has the effects of purging fire, relieving restlessness, clearing heat, promoting diuresis, cooling blood and removing toxicity. Gardenia jasminoidin of Gardenia jasminoides Ellis has effects of improving memory function, lowering blood pressure, reducing diarrhea, promoting bile secretion, promoting collagen synthesis, resisting oxidation, and resisting aging. The linalool contained in the gardenia has good antibacterial activity, can also inhibit the growth of fungi, and has good antibacterial and anti-inflammatory effects. The geniposide has good cardiovascular and cerebrovascular protection effects; the fructus Gardeniae extract also has effects in clearing away heat, protecting liver, resisting cancer, reducing blood lipid, tranquilizing mind, relieving convulsion, improving sleep, promoting learning and memory, resisting aging, and preventing and treating senile dementia;
the dandelion has sweet and slightly bitter taste, mild nature and no toxicity, enters liver and stomach channels, has multiple pharmacological effects of resisting cancer, resisting oxidation, reducing blood sugar, reducing blood fat, resisting thrombus, regulating immunity and the like, can inhibit the proliferation and migration of tumor cells by regulating and controlling cell cycle, destroying the morphology of the tumor cells, inducing apoptosis and has prevention and treatment effects on various tumors such as lung cancer, breast cancer, liver cancer, intestinal cancer, pancreatic cancer, leukemia and the like. The herba Taraxaci has effects of promoting metabolism, whitening skin, removing mottle, reducing pox and pox, and improving eczema. The dandelion can increase the activity of the anabolic steroid enzyme of mouse testicular mesenchymal cells and the synthesis of the steroid, can prevent and improve hypogonadism, and can prevent and delay the sexual function decline;
the medlar is sweet in nature and neutral in taste, enters liver and stomach meridians and lung meridians, and has the effects of nourishing kidney, moistening lung, tonifying liver and improving eyesight. It is indicated for liver and kidney yin deficiency, soreness and weakness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea. The fructus Lycii polysaccharide has effects of regulating immunity, resisting tumor, promoting immunity, resisting aging, resisting tumor, scavenging free radicals, relieving fatigue, resisting radiation, protecting liver, and protecting and improving reproductive function; the lycium barbarum betaine can reduce blood fat and treat fatty liver; the fructus Lycii pigment has effects of resisting oxidation, improving immunity, preventing and inhibiting tumor, and preventing atherosclerosis. The fructus Lycii extract has effects of delaying aging, and preventing and treating senile dementia and Parkinson disease;
the kudzuvine root is sweet and pungent in taste and cool in nature, enters spleen, stomach and lung channels, has the effects of relieving muscles and fever, promoting eruption, promoting the production of body fluid to quench thirst, invigorating yang and stopping diarrhea, clearing and activating the channels and collaterals, relieving alcoholism and the like, and has the effects of relieving fever, resisting inflammation, resisting infection, resisting cancer, reducing blood pressure, blood sugar and blood fat, protecting the liver, protecting the heart, improving osteoporosis, improving reproductive function and the like. Can improve the regeneration capability of liver cells, recover the normal liver function, promote the secretion of bile and prevent the accumulation of fat in the liver; promoting metabolism, enhancing liver detoxification function, and preventing alcohol damage to liver. For coronary arteriosclerosis caused by hyperlipidemia, coronary heart disease, angina pectoris, and myocardial infarction can be prevented and treated by reducing blood lipid and improving myocardial ischemia state; for cerebral arteriosclerosis caused by hyperlipemia, cerebral ischemia state can be improved, and complications such as cerebral infarction, hemiplegia, vascular dementia, etc. can be prevented and treated; enhancing autoimmune function, delaying aging, and promoting hemopoiesis. The kudzu root has the effects of nourishing and beautifying the face of women, preventing black spots, whelks and liver spots from forming, promoting the skin to be white, smooth and fine, and enabling women to be bright and colorful; the kudzuvine root is rich in isoflavone, so that the female breast is plump and firm, the breast tissue is reconstructed, and the kudzuvine root also has a good maintenance effect on the uterus, the ovary and the skin; radix Puerariae can regulate climacteric syndrome, and improve symptoms such as insomnia, dreaminess, dizziness, blurred vision, dysphoria, restlessness, suspicion, and melancholy. With the age, the absorption of calcium by the body is reduced, the calcium is reduced, the bone is decalcified, the osteoporosis is easy to occur, and the kudzuvine root can prevent and treat the osteoporosis;
chrysanthemum, bitter and sweet in taste, slightly cold in nature, enters lung and liver meridians, has the functions of dispelling wind and clearing heat, calming liver and improving eyesight, and clearing heat and removing toxicity. The chrysanthemum has wide pharmacological actions of bacteriostasis, antivirus, antioxidation, liver protection, blood pressure reduction, blood fat reduction, tumor resistance and the like. The chrysanthemum contains abundant essential oil and chrysanthemum pigment, can effectively inhibit the generation of skin melanin, has the effect of softening epidermal cells, and is beneficial to whitening skin, removing freckles and acnes and eliminating wrinkles;
haw, sour and sweet in nature and flavor, warm slightly, enters spleen, stomach and liver meridians. The fructus crataegi extract can dilate coronary artery, increase coronary blood flow, and protect myocardial ischemia and anoxia; and can strengthen heart, lower blood pressure and resist arrhythmia; but also reduce blood fat, resist atherosclerosis, it reduces serum cholesterol and triglyceride; the hawthorn can also have the effects of resisting platelet aggregation, resisting oxidation, enhancing immunity, promoting urination, tranquilizing, contracting uterus, inhibiting bacteria, protecting liver, resisting cancer, resisting aging and the like;
the lotus leaves are bitter and astringent in taste and neutral in nature, and have the effects of clearing away the heart-fire, relieving summer-heat, promoting blood circulation, removing blood stasis, cooling blood, stopping bleeding, raising hair, clearing yang, dispelling wind, eliminating dampness and the like, and the heart and liver meridians are entered; can be used for treating summer heat, polydipsia, summer-heat, dampness, diarrhea, spleen deficiency, and various hemorrhagic diseases caused by blood heat. The lotus leaves have a plurality of pharmacological actions including reducing blood fat, losing weight and inhibiting fatty liver; anti-atherosclerosis, protecting vascular endothelium, and regulating arrhythmia; reducing blood sugar, resisting oxidation and resisting aging; bacteriostasis, antivirus, liver protection and anti-fibrosis; anti-inflammatory, anti-tumor, hemostatic, etc.; the lotus leaf is rich in vitamin C and various alkaloids, such as nuciferine, which has the effects of relaxing bowels, resisting oxidation, clearing toxic and harmful substances in blood, relaxing blood vessels, inhibiting melanin generation and the like, and has obvious effects of beautifying, removing freckles and shaping body;
turmeric has warm nature, bitter, sweet and pungent taste, no toxicity, and enters heart and spleen meridians. Has the effects of breaking blood, promoting qi circulation, stimulating menstrual flow, relieving pain, and caring skin. Has antiinflammatory, antioxidant, blood lipid reducing, blood pressure lowering, anticoagulant, liver protecting, gallbladder promoting, cardiovascular and cerebrovascular protecting, antitumor, and dysmenorrhea and menstrual disorder treating effects. It is worth mentioning that turmeric can brighten, repair and increase skin radiance, turmeric can regulate sebum secretion, inhibit tyrosinase, thereby alleviating the formation of sunburn or pigmentation that results in dark spots; the turmeric is beneficial to keeping the content of collagen and moisture, reducing wrinkles and fine lines, and has the effects of fading color spots, nourishing skin, removing wrinkles and resisting wrinkles in the aspect of beautifying;
red yeast rice is sweet in taste, warm in nature, nontoxic and capable of entering spleen, large intestine and liver meridians. The red yeast rice has the definite functions of losing weight, reducing blood fat, reducing blood sugar and reducing blood pressure, can prevent osteoporosis and senile dementia, and also has the effects of resisting inflammation, resisting cancer and the like. In addition, the red yeast rice has high antioxidant content, can remove oxygen free radicals in vivo, and has good skin caring effect.
In order to realize the practical application of the food formula, the invention also provides a production process of the food formula, which has the core that a plurality of different components are added into water or ethanol-water solution together, different extracting solutions are obtained after certain time of extraction under set conditions, different extracts are obtained by respectively concentrating and evaporating the extracting solutions, and the extracts are automatically granulated after being mixed. According to the production process, effective components in the traditional Chinese medicine components are extracted under the action of ethanol or water on the basis of different extraction methods, and it is required to be noted that the spina date seeds used in the production process also adopt a special ultrasonic extraction mode and are matched with a specific amount of ethanol-water solution and specific reaction parameters, so that the spina date seeds achieve the highest extraction rate, and meanwhile, the broadleaf holly leaf and the honeysuckle also achieve higher extraction rates. Preferably, the ethanol in the extracting solution is separated before the extracting solution is concentrated and evaporated, a rectification method can be adopted to recover the ethanol, the ethanol can be recycled, and the material cost is saved.
The production process of the food formula comprises the following steps:
adding 50 times of 70% ethanol-water solution into folium Ilicis, flos Lonicerae and semen Ziziphi Spinosae, extracting for 3 times (20 min each time) under ultrasonic power of 100W and leaching temperature of 60 deg.C, mixing the three extractive solutions, recovering ethanol until there is no ethanol, and concentrating and evaporating to obtain extract I;
adding semen Cassiae, fructus Gardeniae, herba Taraxaci and fructus Lycii into 28 times of 70% ethanol-water solution, heating and reflux-extracting for 3 times, each time for 2 hr, mixing the three extractive solutions, recovering ethanol until no ethanol exists, and concentrating and evaporating to obtain extract II;
extracting radix Puerariae and fructus crataegi with 80% ethanol-water solution for 2 times, extracting with 12 times of 80% ethanol-water solution for 1 hr, extracting with 10 times of 80% ethanol-water solution for 30min, mixing the extractive solutions, recovering ethanol, and concentrating to remove water to obtain extract III;
adding 20 times of water into the chrysanthemum, the lotus leaves and the turmeric, soaking for 60min, decocting twice, 2 hours for the first time and 1 hour for the second time, combining the decoctions, filtering and drying to obtain an extract IV;
adding 10 times of 60% ethanol-water solution into red rice, extracting at 50 deg.C for 120min twice, recovering ethanol until no ethanol exists, and concentrating and evaporating water to obtain extract V;
mixing the above five extracts, adding soluble starch as binder, placing into rotary dry granulating machine, and directly granulating to obtain edible food granule.
Example 1
And (3) kudingcha: 1 part by weight
Honeysuckle flower: 1 part by weight
Wild jujube seed: 5 parts by weight of
Cassia seed: 1 part by weight
Gardenia: 1 part by weight
Dandelion: 1 part by weight
Medlar: 5 parts by weight of
Kudzu root: 1 part by weight
Chrysanthemum: 1 part by weight
Hawthorn fruit: 5 parts by weight of
Lotus leaf: 5 parts by weight of
Turmeric: 1 part by weight
Red yeast rice: 1 part by weight
Example 2
And (3) kudingcha: 3 parts by weight of honeysuckle: 2 parts of wild jujube seeds: 6.5 parts by weight of cassia seed: 3 parts by weight of gardenia: 3 parts by weight of dandelion: 3 parts of medlar: 7.5 parts by weight of kudzu root: 3 parts of chrysanthemum: 2 parts by weight of hawthorn: 7.5 parts by weight of lotus leaf: 7.5 parts by weight of turmeric: 2 parts of red yeast rice by weight: 2 parts by weight of
Example 3
And (3) kudingcha: 5 parts by weight of honeysuckle: 3 parts of wild jujube seeds: 8 parts of cassia seed: 5 parts by weight of gardenia: 5 parts by weight of dandelion: 5 parts by weight of medlar: 10 parts by weight of
Kudzu root: 5 parts by weight of
Chrysanthemum: 3 parts by weight of
Hawthorn fruit: 10 parts by weight of
Lotus leaf: 10 parts by weight of
Turmeric: 3 parts by weight of
Red yeast rice: 3 parts by weight of
Correspondingly, the invention also provides examples 1-3 according to the production process, corresponding food granules are prepared according to the examples, and animal tests are carried out on the food granules of the examples 1-3.
Example 2 pharmacodynamic test-hypolipidemic test
The material and the method are as follows:
the method is carried out by referring to an auxiliary hypolipidemic functional evaluation program and an auxiliary hypolipidemic functional evaluation method specified in 'health food inspection and evaluation technical Specification' (2003 edition) of the original Ministry of health.
Experimental animals:
wistar male rats weighing 180-.
High-fat feed:
feeding twice a day; high fat diets included: 74% basal feed, 10% lard, 5% sucrose, 5% adult milk powder, 5% egg yolk powder and 1% cholesterol.
Animal grouping and test animals:
after the Wistar male rat is adapted to the animal room for one week, fasting for 12 hours, weighing, and taking tail blood to measure the serum total cholesterol level; three groups of 6 rats were divided according to the body weight and serum TC levels of the rats, and a normal control group, a hyperlipidemia model group, and a drug + hyperlipidemia model group were respectively provided from left to right as shown in fig. 1. The normal control group was given normal diet, the hyperlipidemia model group was all fed with high-fat diet, and the drug + hyperlipidemia model group was fed with the food pellet of example 2, and there was no significant difference between the starting body weight and the serum total cholesterol level of the three groups.
Observation indexes and detection methods:
the method is carried out according to the auxiliary blood fat reducing function test method specified in the technical Specification for testing and evaluating health food (2003 edition) of the original Ministry of health. In the experimental period of 30 days, tail blood is taken to measure blood lipid indexes including serum Total Cholesterol (TC), Triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and the like. The experimental results are as follows:
animal experiments confirmed that, as shown in fig. 2, after administration of the food granules of example 2, the weight, liver weight and epididymal fatty liver weight of mice on a high-fat and high-sugar diet were reduced, and the appearance of liver of the mice on a high-fat and high-sugar diet was restored.
Meanwhile, as shown in fig. 3, the cholesterol content, triglyceride content and free fatty acid content in liver tissues of the mice with high-fat and high-sugar diet are reduced, and the serum glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase levels of the mice with high-fat and high-sugar diet are reduced.
As shown in FIG. 4, the serum total cholesterol and triglyceride levels of the mice with high fat and high sugar are reduced, the fasting blood sugar and the fasting insulin levels of the mice are reduced, and the insulin resistance of the mice with high fat and high sugar is relieved.
The experimental results are as follows:
the experimental result shows that the food formula can reduce serum total cholesterol, triglyceride and low-density lipoprotein cholesterol of the rat with hyperlipidemia and increase high-density lipoprotein cholesterol (HDL-C). According to the standard in the technical Specification for testing and evaluating health food (2003 edition), the product of the invention has the function of reducing blood fat.
The present invention also determined the efficacy of the food particles of examples 1 to 3 in modulating hyperlipidemia in humans. The symptoms of the patients are that the blood fat index is out of the standard range. The patients were divided into 3 groups of 8 patients each, and the first group was administered with the food granules of example 1, the second group with the food granules of example 2, and the third group with the food granules of example 3. Each patient takes two bags of the food granules of the invention every day, each bag is 5g, and the taking course is 4 weeks.
After the food particles of the example 1 are taken, all indexes of blood fat of 4 patients are basically recovered to be normal in 8 patients, and the indexes of 4 patients are obviously improved.
After the food granules in example 3 were taken, the blood lipid indexes of 5 patients were substantially recovered to normal in 8 patients, and the symptoms of 3 patients were significantly alleviated.
After the food granules of example 2 were taken, all the indices of blood lipid of 8 patients were substantially recovered to normal.
The present invention further determined the efficacy of the food particles of example 2 in modulating hyperlipidemia.
Two bags of patients with hyperlipidemia are taken every day, each bag is 5g, and the clinical curative effect observes the index of 16 patients with hyperlipidemia after using the formula for 28 days, and specifically refers to figures 5-11 in the attached drawings of the specification.
From the data in fig. 5-11, the blood lipid index of the treated hyperlipidemia patients is recovered to normal level or close to normal value, which shows that the present invention can effectively reduce blood lipid, protect liver, and especially reduce low density lipoprotein cholesterol.
The present inventors have also discovered additional efficacy of the food particles of example 3 in hyperlipidemic patients after taking the formula.
After a woman 61 years old suffers from hyperlipidemia, long-term chest pain, shortness of breath, haggard face and long-term facial macula, after taking the food particles provided by the invention, each time the food particles are taken by 5 g/bag, the blood lipid index is recovered to be normal, the facial macula is lightened in color, the area is reduced, the skin is glossy and white, and the anti-aging and beautifying effects are achieved.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (4)
1. The food formula for preventing and treating hyperlipidemia is characterized by comprising the following components:
and (3) kudingcha: 1-5 parts by weight
Honeysuckle flower: 1-3 parts by weight
Wild jujube seed: 5-8 parts by weight
Cassia seed: 1-5 parts by weight
Gardenia: 1-5 parts by weight
Dandelion: 1-5 parts by weight
Medlar: 5-10 parts by weight
Kudzu root: 1-5 parts by weight
Chrysanthemum: 1-3 parts by weight
Hawthorn fruit: 5-10 parts by weight
Lotus leaf: 5-10 parts by weight
Turmeric: 1-3 parts by weight
Red yeast rice: 1-3 parts by weight.
2. The food formulation for preventing and treating hyperlipidemia according to claim 1, wherein the content of each ingredient in the food formulation is preferably:
and (3) kudingcha: 3 parts by weight of
Honeysuckle flower: 2 parts by weight of
Wild jujube seed: 6.5 parts by weight
Cassia seed: 3 parts by weight of
Gardenia: 3 parts by weight of
Dandelion: 3 parts by weight of
Medlar: 7.5 parts by weight
Kudzu root: 3 parts by weight of
Chrysanthemum: 2 parts by weight of
Hawthorn fruit: 7.5 parts by weight
Lotus leaf: 7.5 parts by weight
Turmeric: 2 parts by weight of
Red yeast rice: 2 parts by weight.
3. The food formulation for preventing and treating hyperlipidemia according to claim 2, wherein the food formulation is produced by adding several different ingredients together into water or ethanol-water solution, extracting for a certain time under set conditions to obtain different extract solutions, concentrating and evaporating the extract solutions to obtain different extracts, mixing the extracts, and automatically granulating.
4. The food formulation for preventing and treating hyperlipidemia according to claim 3, wherein the production process of the food formulation is specifically as follows:
adding 50 times of 70% ethanol-water solution into folium Ilicis, flos Lonicerae and semen Ziziphi Spinosae, extracting for 3 times (20 min each time) under ultrasonic power of 100W and leaching temperature of 60 deg.C, mixing the three extractive solutions, recovering ethanol until there is no ethanol, and concentrating and evaporating to obtain extract I;
adding semen Cassiae, fructus Gardeniae, herba Taraxaci and fructus Lycii into 28 times of 70% ethanol-water solution, heating and reflux-extracting for 3 times, each time for 2 hr, mixing the three extractive solutions, recovering ethanol until no ethanol exists, and concentrating and evaporating to obtain extract II;
extracting radix Puerariae and fructus crataegi with 80% ethanol-water solution for 2 times, extracting with 12 times of 80% ethanol-water solution for 1 hr, extracting with 10 times of 80% ethanol-water solution for 30min, mixing the extractive solutions, recovering ethanol, and concentrating to remove water to obtain extract III;
adding 20 times of water into the chrysanthemum, the lotus leaves and the turmeric, soaking for 60min, decocting twice, 2 hours for the first time and 1 hour for the second time, combining the decoctions, filtering and drying to obtain an extract IV;
adding 10 times of 60% ethanol-water solution into red rice, extracting at 50 deg.C for 120min twice, recovering ethanol until no ethanol exists, and concentrating and evaporating water to obtain extract V;
mixing the above five extracts, adding soluble starch as binder, placing into rotary dry granulating machine, and directly granulating to obtain edible food granule.
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| CN113508879A (en) * | 2021-07-07 | 2021-10-19 | 长沙清亚灵健康管理有限公司 | Health-care beverage for conditioning hypertension and hyperlipidemia and preparation method thereof |
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| CN101433629A (en) * | 2007-11-16 | 2009-05-20 | 北京因科瑞斯医药科技有限公司 | Chinese medicinal composition with function for reducing blood fat and preparation method thereof |
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| CN109329689A (en) * | 2018-11-12 | 2019-02-15 | 天津市农业生物技术研究中心 | A kind of health solid beverage and preparation method thereof |
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