CN109430867A - A kind of enriching yin and nourishing kidney composition and the preparation method and application thereof - Google Patents
A kind of enriching yin and nourishing kidney composition and the preparation method and application thereof Download PDFInfo
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- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000001717 vitis vinifera seed extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to compositions of a kind of enriching yin and nourishing kidney and the preparation method and application thereof.The components such as Radix Astragali, dendrobium candidum, American Ginseng, Chinese yam, fructus lycii, Poria cocos, green coffee bean and green tea progress compatibility is used in combination composition provided by the invention, synergistic effect can be played, can effective enriching yin and nourishing kidney, improve immunity, anti-aging, fat reducing are made light of one's life by commiting suicide and improve the effect slept.And being found surprisingly that the present composition, there is no influence sleeping problems brought by green coffee bean and green tea because using.In addition the raw materials used safety of the composition, preparation method is simple, easy to spread.
Description
Technical field
The present invention relates to functional food fields, and in particular to a kind of composition of enriching yin and nourishing kidney and the preparation method and application thereof.
Background technique
Modern society women plays various rolls, carries various pressure.It is allegro to live in the female that overdraws
The health of property.Due to the influence of people's bad life habits such as stay up late work, all night play, night should fall asleep and egersis, sun
Yin should be entered and floated on outside, caused sun not enter the long yin of yin, yang and disappear, yin-fluid consumption in kidney is caused excessively, the table that kidney yin leaks occur
It is existing.Keep women scalp portion fat secretion excessive, Yi Shanghuo, gum are red and swollen, and acne or even fecundity decline increasingly, easily
There is paramenia, Tidal fever with perspiration, amnesia insomnia, loose stool or constipation, emotional, tired etc..
Chinese medicine thinks that the kidney being the origin of congenital constitution, and kidney has the raw marrow of main bone, store essential substances to receive the function of gas.Off-balancesheet in source, kidney health
It is ruddy that in high spirits, skin could be made one from inside to outside.
People are not only higher to requiring in women work and viability, and also more focus on women appearance bearing.
It is not intended merely to delay senescence, more thirsts for possessing graceful stature.
Urgently develop at present it is a kind of for women can enriching yin and nourishing kidney from inside to outside, make that women is in high spirits, skin is ruddy,
The product of anti-aging and slimming effect can be reached again to meet pursuit of the women to health and beauty.
Summary of the invention
The purpose of the present invention is overcome the deficiencies of the prior art and provide a kind of composition especially to have effect of nourishing Yin and invigorating kidney
Composition.Composition provided by the invention is by Radix Astragali, dendrobium candidum, American Ginseng, Chinese yam, fructus lycii, Poria cocos, green coffee bean and green
The components such as tea carry out compatibility and are used in combination, and can play synergistic effect, can effectively enriching yin and nourishing kidney, raising be immunized
The effect that power, anti-aging and fat reducing are made light of one's life by commiting suicide.And it is found surprisingly that there is no because using green coffee bean for the present composition
And sleeping problems are influenced brought by green tea.In addition the raw materials used safety of the composition, preparation method is simple, easy to spread.
Specifically, composition provided by the invention uses the raw material including following active constituent to be prepared: Radix Astragali, iron
Skin dendrobium nobile, American Ginseng, Chinese yam, fructus lycii, Poria cocos, green coffee bean and green tea.
The Radix Astragali that the present invention uses meets States Pharmacopoeia specifications.Radix Astragali have invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis, myogenic work
With for deficiency of vital energy and acking in strength, rush down prolapse of the anus for a long time, spontaneous perspiration, oedema, sub-official prolapses, chronic rephrilis protinuria, diabetes, the long disunion of the open sore part.
The dendrobium candidum that the present invention uses meets States Pharmacopoeia specifications.Dendrobium candidum is orchid family herbaceous plant, sweet in flavor, cold nature,
There is the effect of promoting fluid production and nourishing stomach, nourishing Yin and clearing heat, moistening lung kidney-nourishing, improving eyesight strong waist.
The American Ginseng that the present invention uses meets States Pharmacopoeia specifications.American Ginseng is Araliaceae Panax herbs perennial vegetation, not
Name American ginseng, American ginseng, Western ginseng can enhance central nervous system function, protection cardiovascular system, improve immunity, treatment
Diabetes, tonifying lung fall fire, nourishing the stomach to improve the production of body fluid.
The Chinese yam that the present invention uses meets States Pharmacopoeia specifications.Chinese yam is the dry rhizome of Dioscoreaceae plant Chinese yam.Chinese yam is sweet in flavor,
Mild-natured, returns spleen, lung, kidney channel are adjustable immunity, anti-oxidant, anti-aging, antitumor, have obvious hypoglycemic effect.
The fructus lycii that the present invention uses meets States Pharmacopoeia specifications.Fructus lycii is the dry mature fruit of Lycium barbarum L. of solanaceae.Fructus lycii taste
It is sweet, it is mild-natured, return liver and kidney channel, has the function of strengthen immunity, anti-oxidant, reducing blood lipid, hypoglycemic, protection liver and anti-aging.
The Poria cocos that the present invention uses meets States Pharmacopoeia specifications.Poria cocos is the dry sclerotia of polyporaceae fungus, sweet in flavor,
Light, mild-natured, return heart, lung, spleen, kidney channel have the effect of clearing damp and promoting diuresis, invigorating the spleen, calming heart, have strengthen immunity, antitumor, anti-ageing
Always, the effects of reducing blood lipid, liver protection, diuresis, anti-inflammatory, sleeping.
The green coffee bean that the present invention uses is the seed of madder wort Coffea arabica, middle fruit coffee or big fruit coffee,
Content of Chlorogenic Acid class compound accounts for coffee bean dry weight 0.2%-10%.Chlorogenic acid compound has anti-oxidant, antiviral, anticancer etc.
A variety of effects, while there is certain inhibiting effect to hyperlipidemia, hypertension and artery sclerosis.
The green tea that the present invention uses is also known as azymic tea, be it is not fermented, the techniques system such as directly finished, rubbed, being dried
At one grow tea, pharmacological component rich in.
Raw material selected by the present invention is safe to the human body, environmentally friendly.The present invention creatively has found, will be these types of
Ingredient carries out compatibility and is used in combination, and can play synergistic effect, effectively enriching yin can support kidney, improve immunity, by
Interior and outer nourishing while achieving the effect that anti-aging, fat reducing are made light of one's life by commiting suicide moulding.The present invention passes through largely practice discovery, each component
Between can more fully play synergistic effect, while kidney, strengthen immunity are supported in enriching yin, reduction superabundant fats,
And play the role of removing free radical anti-aging.And easily insomnia etc. brought by not due to using green tea and green coffee bean
Side effect.From multi-angle regulation body allomeric function, then realize that kidney is supported in enriching yin, fat reducing is made light of one's life by commiting suicide, the effect of anti-aging.
As a preferred solution of the present invention, the composition in parts by weight, including following active constituent or use
Raw material including following active constituent is prepared:
Further, the composition includes following active constituent or uses including following active constituent in parts by weight
Raw material is prepared:
Composition provided by the invention can be only by Radix Astragali, dendrobium candidum, American Ginseng, Chinese yam, fructus lycii, Poria cocos, green coffee
Beans and green tea are prepared for active constituent.
Composition provided by the invention can also assist Radix Astragali, dendrobium candidum, American Ginseng, Chinese yam, Chinese holly using other raw materials
Qi, Poria cocos, green coffee bean and green tea play effect, further realize synergistic effect, thus multi-angle regulation body allomeric function,
Then the effect of enriching yin and nourishing kidney etc. is realized.One of royal jelly, grape pip etc. or a variety of can be selected in other raw materials.
Royal jelly also known as royal jelly that the present invention uses, bee milk, emperor's slurry, royal jelly, are the tongues of apidae insect 5-15 age in days
The secretion of gland and mandibular gland, for feeding the white or faint yellow emulsion liquid of queen bee and 1-3 age in days bee larva.Royal jelly
Complicated component, be collect nutrition, dietotherapy and health care many integration natural materials, have antibacterial, anti-oxidant, anti-aging, it is hypoglycemic,
Reducing blood lipid, antitumor, adjusting are immunized and other many-sided physiological actions such as cosmetology.Bee in the preferably described composition of the present invention
The dosage of royal jelly is 1-15 parts, preferably 2-10 parts.
The grape pip that the present invention uses is the seed of grape, and grape seed extract is mainly by procyanidine, catechin, table
Catechin, gallic acid, the polyphenols such as L-Epicatechin gallate composition.Grape in the preferably described composition of the present invention
The dosage of seed is 10-25 parts, preferably 12-20 parts.
In the preferred above-mentioned composition of the present invention royal jelly, grape pip jointly with Radix Astragali, dendrobium candidum, American Ginseng, Chinese yam, Chinese holly
Qi, Poria cocos, green coffee bean and green tea use.
Composition provided by the invention can be prepared according to the method for this field routine.In order to further increase above-mentioned group
The health-care effects such as the enriching yin and nourishing kidney of object are closed, and convenient for being mixed with product as effective component and auxiliary material, the present invention is preferably described
Composition is prepared with the following method: taking Radix Astragali, dendrobium candidum, American Ginseng, Chinese yam, fructus lycii, Poria cocos, green coffee bean, green
Tea, or grape pip is further added；It is cooked by slow fire after sufficiently being impregnated after mixing with water, then ultrasonic extraction, separates supernatant, it is dense
Contracting, it is dry；Or royal jelly is further added, mix to get.The present invention is by largely practice discovery, by raw material elder generation mild fire
Decoction, again ultrasonic extraction, the effective component in each raw material can be enriched with by resulting extract to greatest extent, so that it is guaranteed that having
Synergistic effect can be played between effect ingredient.
The present invention protects the composition light in preparation enriching yin and nourishing kidney or raising immunity or anti-aging or fat reducing simultaneously
Body or the food for improving the functions such as sleep or the application in health care product or drug.
Specifically, the food provided by the invention or health care product or drug, be using the composition as effective component,
The customary adjuvant of food or health care product is added, or pharmaceutically available auxiliary material is added, is prepared into according to conventional methods in the art
Various dosage forms.
Specifically, the present invention provides a kind of granule, it further include bonding on the basis of composition provided by the invention
Agent, disintegrating agent, corrigent and filler.
The adhesive can be selected from one of starch slurry, gelatin solution, sodium cellulose glycolate, hydroxypropyl cellulose
Or it is several.In the raw material of the tablet, the dosage of described adhesive is preferably 0.01-8 parts, more preferably 0.1-0.5 parts.
It is fine that the disintegrating agent can be selected from dried starch, Sodium Hydroxymethyl Stalcs, low-substituted hydroxypropyl cellulose sodium, crosslinking methylol
Tie up one or more of plain sodium.In the raw material of the tablet, the dosage of the disintegrating agent is preferably 0.01-3 parts, more preferably
It is 0.5-1 parts.
The corrigent can be selected from one in saccharin sodium, Sucralose, honey element, stevioside, Aspartame or stevioside
Kind is several.In the raw material of the tablet, the dosage of the corrigent is preferably 0.01-1.5 parts, more preferably 0.1-0.5 parts.
The filler can be selected from one or more of starch, dextrin, mannitol, antierythrite, microcrystalline cellulose.?
In the raw material of the tablet, the dosage of the filler is preferably 0.5-10 parts, more preferably 0.5-1 parts.
As a kind of specific embodiment of the invention, the granule is using the composition as effective component, including such as
The component of lower parts by weight:
As a kind of specific embodiment of the invention, the granule is using the composition as effective component, including such as
The component of lower parts by weight:
Present invention simultaneously provides the preparation method of above-mentioned granule, specifically comprise the following steps: by the composition first with
Filler, disintegrating agent and corrigent are uniformly mixed, and are added adhesive and are uniformly mixed, it is dry after whole grain to get.
Composition provided by the invention is with Radix Astragali, dendrobium candidum, American Ginseng, Chinese yam, fructus lycii, Poria cocos, royal jelly, grape
Seed, green coffee bean and green tea etc. be used as raw material, above-mentioned raw materials be it is safe to the human body, it is environmentally friendly；By these types of ingredient
Compatibility is carried out to be used in combination, it is synergistic, effectively the feeding kidney of enriching yin, raising immunity, fat reducing it can make light of one's life by commiting suicide, delay senescence, and
Edible safety has no toxic side effect.
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..It is not specified in embodiment specific
Technology or conditions person, described technology or conditions according to the literature in the art, or carried out according to product description.It is used
Production firm person is not specified in reagent or instrument, is the conventional products that can be commercially available by regular distributor.
Embodiment 1
A kind of composition of enriching yin and nourishing kidney, is prepared using the following raw material: Radix Astragali 23kg, dendrobium candidum 2kg, American Ginseng
3kg, Chinese yam 10kg, fructus lycii 4kg, Poria cocos 5kg, green coffee bean 5kg, green tea 10kg.
The preparation method of composition: taking each raw material, is cooked by slow fire after sufficiently being impregnated after mixing with water, then ultrasonic extraction
30min, separate supernatant, concentration, spray drying to get.
Embodiment 2
A kind of composition of enriching yin and nourishing kidney, is prepared using the following raw material: Radix Astragali 2kg, dendrobium candidum 10kg, American Ginseng
2kg, Chinese yam 4kg, fructus lycii 8kg, Poria cocos 3kg, green coffee bean 28kg, green tea 5kg.
The preparation method of composition is same as Example 1.
Embodiment 3
A kind of composition of enriching yin and nourishing kidney, is prepared using the following raw material: Radix Astragali 15kg, dendrobium candidum 5kg, American Ginseng
1kg, Chinese yam 2kg, fructus lycii 2kg, Poria cocos 1kg, green coffee bean 12kg, green tea 24kg.
The preparation method of composition is same as Example 1.
Embodiment 4
A kind of composition of enriching yin and nourishing kidney, is prepared using the following raw material: Radix Astragali 5kg, dendrobium candidum 12kg, American Ginseng
5kg, Chinese yam 7kg, fructus lycii 10kg, Poria cocos 10kg, green coffee bean 7kg, green tea 6kg.
Embodiment 5
A kind of composition of enriching yin and nourishing kidney, is prepared using the following raw material: Radix Astragali 10kg, dendrobium candidum 10kg, the West
Join 6kg, Chinese yam 6kg, fructus lycii 6kg, Poria cocos 6kg, green coffee bean 10kg, green tea 8kg, royal jelly 2kg, grape pip 20kg.
The preparation method of composition: each raw material except royal jelly is removed, is cooked by slow fire after sufficiently being impregnated after mixing with water
It boils, then ultrasonic extraction 30min, separates supernatant, be concentrated, spray drying；Royal jelly is added, is mixed；To obtain the final product.
Embodiment 6
A kind of composition of enriching yin and nourishing kidney, is prepared using the following raw material: Radix Astragali 8kg, dendrobium candidum 8kg, American Ginseng
4kg, Chinese yam 9kg, fructus lycii 5kg, Poria cocos 7kg, green coffee bean 9kg, green tea 12kg, royal jelly 6kg, grape pip 16kg.
The preparation method of composition is same as Example 5.
Embodiment 7
A kind of composition of enriching yin and nourishing kidney, is prepared using the following raw material: Radix Astragali 9kg, dendrobium candidum 9kg, American Ginseng
5kg, Chinese yam 5kg, fructus lycii 6kg, Poria cocos 6kg, green coffee bean 12kg, green tea 10kg, royal jelly 10kg, grape pip 12kg.
The preparation method of composition is same as Example 5.
Embodiment 8
A kind of granule of enriching yin and nourishing kidney, the composition 8.7kg provided using embodiment 1 are also further as effective component
It is added following auxiliary material: sodium cellulose glycolate 0.25kg, dried starch 0.75kg, magnesium stearate 0.05kg, saccharin sodium 0.25kg is micro-
Crystalline cellulose 0.5kg.
The preparation method of the granule: the composition is mixed with dried starch, saccharin sodium and microcrystalline cellulose
It is even, add sodium cellulose glycolate, be uniformly mixed, after wet grain is dry, whole grain to get.
Embodiment 9
A kind of granule of enriching yin and nourishing kidney, compared with Example 8, difference is only that, the group provided with the embodiment 2 of equivalent
Conjunction object is effective component.
Embodiment 10
A kind of granule of enriching yin and nourishing kidney, compared with Example 8, difference is only that, the group provided with the embodiment 3 of equivalent
Conjunction object is effective component.
Embodiment 11
A kind of granule of enriching yin and nourishing kidney, compared with Example 8, difference is only that, the group provided with the embodiment 4 of equivalent
Conjunction object is effective component.
Embodiment 12
A kind of granule of enriching yin and nourishing kidney, compared with Example 8, difference is only that, the group provided with the embodiment 5 of equivalent
Conjunction object is effective component.
Embodiment 13
A kind of granule of enriching yin and nourishing kidney, compared with Example 8, difference is only that, the group provided with the embodiment 6 of equivalent
Conjunction object is effective component.
Embodiment 14
A kind of granule of enriching yin and nourishing kidney, compared with Example 8, difference is only that, the group provided with the embodiment 7 of equivalent
Conjunction object is effective component.
Comparative example 1
A kind of composition, is prepared using the following raw material: dendrobium candidum 2kg, American Ginseng 3kg, Chinese yam 10kg, fructus lycii
4kg, Poria cocos 5kg, green tea 10kg.Preparation method is same as Example 1.
Comparative example 2
A kind of composition, is prepared using the following raw material: Radix Astragali 5kg, American Ginseng 5kg, Chinese yam 7kg, fructus lycii 10kg, Fu
Siberian cocklebur 10kg, green coffee bean 7kg.Preparation method is same as Example 1.
Comparative example 3
A kind of composition, is prepared using the following raw material: Radix Astragali 10kg, dendrobium candidum 10kg, Chinese yam 6kg, fructus lycii
6kg, Poria cocos 6kg, green coffee bean 10kg, green tea 8kg, royal jelly 2kg.Preparation method is same as Example 5.
Comparative example 4
Green-tea extract, preparation method: being cooked by slow fire after taking green tea sufficiently to be impregnated with water, then ultrasonic extraction 30min, separation
Supernatant, concentration, spray drying to get.
Comparative example 5
Preparation method: green coffee bean extract is cooked by slow fire, then ultrasonic extraction after taking green coffee bean sufficiently to be impregnated with water
30min, separate supernatant, concentration, spray drying to get.
1 enriching yin and nourishing kidney of experimental example experiment
SD female rats 120,200 ± 20g of weight are chosen, is randomly divided into 12 groups, every group 10: blank control group, mould
Type control group, comparative example 1-3 group, embodiment 1-7 group.
In addition to blank control group mouse carries out sham-operation, other group of mouse carries out oophorectomy.
Blank control group, model control group stomach-filling physiological saline (10mlkg-1·bw)；
Comparative example 1-3 and embodiment 1-7 group give corresponding composition 833mgkg-1·bw。
The daily stomach-filling of every group of rat is primary.Continuous gavage 42d.
Last stomach-filling simultaneously after fasting 12h, operates measurement E according to each medicine box specification with radioimmunoassay2(estradiol), LH (promote
Lutropin), FSH (follicle-stimulating hormone (FSH)) content.It the results are shown in Table 1.
Table 1: rat blood serum E2, LH, FSH measurement result (n=10)
| Group | E2(pg/ml) | LH(pg/ml) | FSH(pg/ml) |
| Blank control group | 26.07±3.92 | 3.45±0.07 | 2.29±0.24 |
| Model control group | 15.83±2.61* | 6.71±0.32* | 4.36±0.47* |
| Comparative example 1 | 17.21±2.36 | 5.37±0.25 | 3.89±0.37 |
| Comparative example 2 | 17.93±3.17 | 5.68±0.19 | 3.84±0.32 |
| Comparative example 3 | 18.87±3.54 | 5.23±0.27 | 3.76±0.28 |
| Embodiment 1 | 23.85±2.31##△△ | 4.29±0.23##△△ | 3.12±0.27##△△ |
| Embodiment 2 | 23.59±3.42##△△ | 4.74±0.27##△△ | 3.19±0.31##△△ |
| Embodiment 3 | 22.79±2.16##△△ | 4.91±0.18##△△ | 3.31±0.24##△△ |
| Embodiment 4 | 24.28±3.97##△△ | 4.13±0.24##△△ | 2.82±0.32##△△ |
| Embodiment 5 | 26.21±3.64##△△ | 3.41±0.16##△△ | 2.25±0.39##△ |
| Embodiment 6 | 25.32±2.83##△△ | 3.86±0.22#△△ | 2.41±0.21##△△ |
| Embodiment 7 | 25.65±2.79##△△ | 3.61±0.26##△△ | 2.38±0.26##△△ |
Note: model control group is compared with blank control group, and * represents P < 0.01；Each experimental group is compared with model control group,#
P < 0.05 is represented,##Represent P < 0.01；Embodiment 1-7 is compared with comparative example 1-3,△P < 0.05 is represented,△△Represent P < 0.01.
After animal is put to death, adrenal gland is taken out in dissection, weighs Organ weight, calculates organ coefficient.
Organ coefficient=Organ weight (mg)/weight (g)
It the results are shown in Table 2.
Table 2: the measurement result of adult rat adrenal tissue organ coefficient
| Group | n | Adrenal gland coefficient |
| Blank control group | 10 | 0.174±1.723 |
| Model control group | 10 | 0.131±2.736* |
| Comparative example 1 | 10 | 0.143±2.318 |
| Comparative example 2 | 10 | 0.147±2.152 |
| Comparative example 3 | 10 | 0.149±2.374 |
| Embodiment 1 | 10 | 0.163±1.642##△△ |
| Embodiment 2 | 10 | 0.160±1.237##△△ |
| Embodiment 3 | 10 | 0.158±1.871##△ |
| Embodiment 4 | 10 | 0.167±1.733##△△ |
| Embodiment 5 | 10 | 0.175±1.836##△△ |
| Embodiment 6 | 10 | 0.171±1.513##△△ |
| Embodiment 7 | 10 | 0.172±2.041##△△ |
Note: model control group is compared with blank control group, and * represents P < 0.01；Each experimental group is compared with model control group,#
P < 0.05 is represented,##Represent P < 0.01；Embodiment 1-7 is compared with comparative example 1-3,△P < 0.05 is represented,△△Represent P < 0.01.
Compared with comparative example 1-3 group, the present composition can significantly improve E2Level significantly improves adrenal gland coefficient,
It is horizontal to reduce LH, FSH, plays adjusting organism endocrine, improves adrenal cortex morphological function, to reach the work of enriching yin and nourishing kidney
With.
Experimental example 2 improves immunity experiment
1, laboratory sample
Embodiment 1-7 and comparative example 1-3 composition.
2, experimental method
Kunming mouse 330 are chosen, weight 18-22g is randomly divided into 3 big groups, is divided into 11 groups: blank pair per big group
According to group, comparative example 1-3 group, embodiment 1-7 group, every group 10, each group gives the agent of correspondent composition in addition to blank control group
Amount is 833mgkg-1Bw, gastric infusion；Once a day, following index is measured after successive administration 30d.Blank control group fills
Stomach gives isometric distilled water.
ConA inducing mouse Splenic vein hemodynamics the results are shown in Table 3, and the tardy kenel reaction result of mouse is shown in Table 4, NK cell
Active measurement result is shown in Table 5.
The experiment of 3 ConA inducing mouse Splenic vein hemodynamics of table
Note: embodiment 1-7 group is compared with blank control group, and * represents P < 0.01；Embodiment 1-7 is compared with comparative example 1-3
,△P < 0.05 is represented,△△Represent P < 0.01.
The tardy kenel reaction of 4 mouse of table
Note: embodiment 1-7 group is compared with blank control group, and * represents P < 0.01；Embodiment 1-7 is compared with comparative example 1-3
,△P < 0.05 is represented,△△Represent P < 0.01.
The measurement of 5 NK cell activity of table
| Group | Animal (only) | NK cell activity % |
| Blank control group | 10 | 27.73±6.37 |
| Comparative example 1 | 10 | 30.13±5.41 |
| Comparative example 2 | 10 | 29.87±6.32 |
| Comparative example 3 | 10 | 29.21±5.68 |
| Embodiment 1 | 10 | 35.06±6.56*△△ |
| Embodiment 2 | 10 | 34.96±6.89*△△ |
| Embodiment 3 | 10 | 34.23±5.37*△△ |
| Embodiment 4 | 10 | 35.67±6.01*△△ |
| Embodiment 5 | 10 | 39.28±5.76*△△ |
| Embodiment 6 | 10 | 37.83±7.17*△△ |
| Embodiment 7 | 10 | 38.67±6.46*△△ |
Note: embodiment 1-7 group is compared with blank control group, and * represents P < 0.01；Embodiment 1-7 is compared with comparative example 1-3
,△P < 0.05 is represented,△△Represent P < 0.01.
It can be seen that from table 3, table 4, table 5, compared with blank control group and comparative example 1-3 group, embodiment 1-7 group can be significant
Improve normal mouse lymphopoiesis ability, swelling degree of the paw and NK cell activity.Show that this composition has and improves body
Immunity enhances the effect of body resistance against diseases.
Experimental example 3, which delays senescence, tests
Kunming mouse 120, weight 18-22g are chosen, is randomly divided into 12 groups, every group 10: blank control group, model
Control group, comparative example 1-3 group (833mgkg-1Bw), embodiment 1-7 group (833mgkg-1·bw).Except blank control group
0.5mL 5%D- galactose solution is injected under the daily nape of remaining outer each group, blank control group gives isometric physiological saline water,
Once a day, after continuously giving mouse tested material 30 days, measurement serum, liver, brain tissue malonaldehyde (MDA) content and SOD are living
Property the results are shown in Table 6 and table 7.
Table 6: the influence to mouse MDA content
| Group | Serum/(nmol/mL) | Liver/(nmol/mg) | Brain tissue/(nmol/mg) |
| Blank control group | 6.07±0.37 | 4.08±1.16 | 15.13±0.73 |
| Model control group | 7.78±0.0.74* | 11.62±1.27* | 18.74±1.16* |
| Comparative example 1 | 6.94±0.57 | 11.07±1.12 | 16.87±0.82 |
| Comparative example 2 | 7.12±0.6.8 | 11.28±1.67 | 17.03±1.13 |
| Comparative example 3 | 7.21±0.72 | 11.08±1.31 | 17.29±1.27 |
| Embodiment 1 | 6.57±0.63##△△ | 8.89±1.28##△△ | 16.16±1.62##△△ |
| Embodiment 2 | 6.61±0.73##△△ | 9.54±1.43##△△ | 16.38±1.37##△ |
| Embodiment 3 | 6.73±0.64#△ | 9.83±1.14##△△ | 16.31±1.14##△△ |
| Embodiment 4 | 6.42±0.62##△△ | 8.43±1.13##△△ | 15.97±1.18##△△ |
| Embodiment 5 | 6.21±0.76##△△ | 5.47.±1.27##△△ | 15.64±1.04##△△ |
| Embodiment 6 | 6.39±0.78##△△ | 6.72±1.08##△△ | 15.74±0.97##△△ |
| Embodiment 7 | 6.32±0.56##△△ | 6.11±1.14##△△ | 15.93±1.19##△△ |
Note: model control group is compared with blank control group, and * represents P < 0.01；Each experimental group is compared with model control group,#
P < 0.05 is represented,##Represent P < 0.01；Embodiment 1-7 is compared with comparative example 1-3 group,△P < 0.05 is represented,△△Represent P <
0.01。
Table 7: on the active influence of SOD in Mice
Note: model control group is compared with blank control group,*Represent P < 0.01；Each experimental group is compared with model control group,#
P < 0.05 is represented,##Represent P < 0.01；Embodiment 1-7 group is compared with comparative example 1-3 group,△P < 0.05 is represented,△△Represent P <
0.01。
It can be seen from the above result that the present composition can reduce serum, liver, MDA content in brain tissue, can be improved
Serum, liver, SOD activity in brain tissue, have the function that anti-aging.
4 fat reducing of experimental example experiment
Animal: SD male rat, weight 200 ± 20g, 120.Random grouping, every group 10.High lipid food uses 2%
Cholesterol, 10% lard, 0.5% cholate, 0.2% methylthiouracil, 87.3% basal feed.Except blank control group is fed daily
It eats outside basal feed 20g, the daily feeding high lipid food 20g of remaining each group, it is continuous to feed three Zhou Jianmo.By as follows after modeling successfully
Scheme feeding rat:
Blank control group: basal feed and distilled water；
Model control group: high lipid food and distilled water；
Experimental group group: high lipid food and each embodiment 1-7 or comparative example 1-3 correspond to composition 833mgkg-1·bw；
It is continuous to feed after three weeks, it is deprived of food but not water 12h, eyeball blood sampling detection total cholesterol (TC), triglyceride (TG) refer to
Mark.It is shown in Table 8.
Table 8: influence of the composition to High fat diet rats blood lipid
| Group | TC | TG |
| Blank control group | 1.62±0.27 | 0.37±0.13 |
| Model control group | 8.53±0.54* | 0.95±0.17* |
| Comparative example 1 | 7.24±0.62 | 0.75±0.21 |
| Comparative example 2 | 7.13±0.72 | 0.73±0.17 |
| Comparative example 3 | 7.78±0.61 | 0.78±0.18 |
| Embodiment 1 | 5.13±0.58##△△ | 0.57±0.16##△△ |
| Embodiment 2 | 5.71±0.37##△△ | 0.61±0.12##△△ |
| Embodiment 3 | 5.93±0.36##△△ | 0.63±0.13##△△ |
| Embodiment 4 | 4.75±0.54##△△ | 0.56±0.19##△△ |
| Embodiment 5 | 2.83±0.68##△△ | 0.48±0.11##△△ |
| Embodiment 6 | 3.93±0.61##△△ | 0.53±0.16##△△ |
| Embodiment 7 | 3.57±0.53##△△ | 0.50±0.13##△△ |
Note: model control group is compared with blank control group, and * represents P < 0.01；Each experimental group is compared with model control group,#
P < 0.05 is represented,##Represent P < 0.01；Embodiment 1-7 is compared with comparative example 1-3,△P < 0.05 is represented,△△Represent P < 0.01.
The result shows that the experimental group of feeding embodiment 1-7 composition can significantly reduce TC and TG in blood, have bright
Aobvious hypolipemic function.
5 sleep experiments of experimental example
Improve the sleep function method of inspection with reference to " health food is examined and assessment technique specification (2003 editions) ".
Kunming mouse 100, weight 18-22g are chosen, is randomly divided into 10 groups, every group 10: blank control group, comparison
Example 4-5 group (833mgkg-1Bw) embodiment 1-7 group (833mgkg-1·bw).Successive administration 7 days, blank control group was given
Give equal capacity distilled water stomach-filling.
Last dose 1h presses 44mgkg-1Bw dosage injects Nembutal sodium solution to mouse peritoneal.Record penta bar of ratio
Appropriate sodium injection time, mouse time for falling asleep and sleep end time, time for falling asleep and injection time difference are calculated as Sleep latency, sleep
Dormancy end time and time for falling asleep difference are calculated as sleeping time.Record is shown in Table 9.
The experiment of 9 mice sleep incidence of table
| Group | Sleep latency (min) | Sleeping time (min) |
| Blank control group | 10.29±1.47 | 16.36±4.31 |
| Comparative example 4 | 15.31±2.93## | 12.58±4.87## |
| Comparative example 5 | 16.71±2.17## | 11.29±5.91## |
| Embodiment 1 | 10.73±2.17△** | 15.94±6.73△** |
| Embodiment 2 | 10.86±2.69△* | 15.57±7.36△** |
| Embodiment 3 | 9.98±2.37△** | 15.63±8.67△** |
| Embodiment 4 | 9.61±1.72△** | 16.04±6.51△** |
| Embodiment 5 | 9.29±1.64△** | 16.78±3.97△** |
| Embodiment 6 | 9.56±1.53△** | 16.12±7.56△** |
| Embodiment 7 | 9.53±2.82△** | 16.64±8.91△** |
Note: embodiment 1-7 group compared with blank control group,△Represent P > 0.01；Embodiment 1-7 group and 4,5 groups of comparative example
It compares, * represents P < 0.05；* represents P < 0.01；4,5 groups of comparative example compared with blank control group,#P < 0.05 is represented,##Generation
Table P < 0.01.
It can be seen from the above result that embodiment 1-7, which has been effectively relieved, uses green coffee bean or green tea compared with comparative example 4,5
The brought influence to sleep.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, fall within the scope of the claimed invention without departing from theon the basis of the spirit of the present invention.
Claims (9)
1. a kind of composition, which is characterized in that in parts by weight include following component:
2. composition according to claim 1, which is characterized in that in parts by weight include following component:
3. composition according to claim 1 or 2, which is characterized in that further include 1-15 parts of royal jelly and/or grape pip
10-25 parts.
4. composition according to claim 1 or 2, which is characterized in that further include 2-10 parts of royal jelly and/or grape pip
12-20 parts.
5. the preparation method of any one of the claim 1-4 composition characterized by comprising take Radix Astragali, dendrobium candidum,
American Ginseng, Chinese yam, fructus lycii, Poria cocos, green coffee bean, green tea, or grape pip is further added；After sufficiently being impregnated after mixing with water
It is cooked by slow fire, then ultrasonic extraction, separates supernatant, be concentrated, it is dry；Or royal jelly is further added, mix to get.
6. any one of the claim 1-4 composition or the composition of claim 5 the method preparation are mended in preparation enriching yin
Kidney or improve immunity or anti-aging or fat reducing make light of one's life by commiting suicide or improve sleep function food or the application in health care product or drug.
7. a kind of granule, the combination prepared including any one of the claim 1-4 composition or claim 5 the method
Object.
8. granule according to claim 7, which is characterized in that the component including following parts by weight:
9. granule according to claim 7, which is characterized in that the component including following parts by weight:
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| CN110934295A (en) * | 2019-12-22 | 2020-03-31 | 重庆申高生化制药股份有限公司 | Composition with body building and kidney nourishing effects and preparation method thereof |
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