CN115068560A - 一种具有通便功能的豆腐柴组合物 - Google Patents
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Abstract
本发明提供一种具有通便功能的豆腐柴组合物，该组合物以豆腐柴叶、石斛、黄精、番木瓜、决明子为原料，各原料按照特定重量比配伍后，经粉碎、醇提、水提、浓缩、干燥、还原混合等步骤制得。本发明制备的豆腐柴组合物经小鼠活体试验验证，能够显著改善洛哌丁胺诱导的肠蠕动抑制，具有通便功能。
Description
技术领域
本发明属于功能食品开发技术领域，具体涉及一种具有通便功能的豆腐柴组合物。
技术背景
豆腐柴，马鞭科豆腐柴属多年生落叶灌木，是一种药食兼用植物资源，豆腐柴叶营养丰富，富含果胶，具有清热解毒、润肠通便、消肿止血、调节免疫等功效。
石斛，兰科石斛属多年生草本植物，味甘，性微寒，归胃、肾经，益胃生津，滋阴清热，用于热病津伤，口干烦渴，胃阴不足，阴虚火旺，目暗不明。
黄精，百合科黄精属植物，重要的药食同源原料，主要活性成分包括多糖、氨基酸、黄酮、蒽醌类化合物等，可用于脾胃虚弱、体倦乏力、口干食少、肺虚燥咳、精血不足等症。
番木瓜，番木瓜科番木瓜属植物，富含膳食纤维、碳水化合物、蛋白质、脂肪、维生素及多种生物活性成分，熟果可利大小便。
决明子，豆科植物决明的干燥成熟种子，味苦、甘、咸，性微寒，入肝、肾、大肠经，润肠通便，降脂明目，治疗便秘及高血脂，高血压。
本发明以豆腐柴叶、石斛、黄精、番木瓜、决明子五种成分为原料，开发一种具有通便功能的豆腐柴组合物。
发明内容
本发明以豆腐柴叶、石斛、黄精、番木瓜、决明子五种成分为原料，各原料按照特定重量比配伍后，经粉碎、醇提、水提、浓缩、干燥、还原混合等步骤制得豆腐柴组合物。经小鼠活体试验验证，本发明制备的豆腐柴组合物能够显著改善洛哌丁胺诱导的肠蠕动抑制，具有通便功能。
本发明的具体实现步骤如下：
1、原料混合：按照重量份称取豆腐柴叶15～20份、石斛5～7份、黄精3～5份、番木瓜1～3份、决明子1～3份，混合均匀后粉碎，制得混合原料粉末；
2、醇提物制备：在混合原料粉末中按照料液比1g：50mL加入无水乙醇，在25℃条件下搅拌浸提24h，过滤分离滤渣和滤液，滤渣干燥备用，滤液经浓缩、干燥，制得醇提物；
3、水提物制备：在干燥后的滤渣中按照料液比1g：50mL加入蒸馏水，在80℃条件下搅拌提取2h，过滤取滤液，滤液经浓缩、干燥，制得水提物；
4、将醇提物和水提物按照提取率比例还原混合，制得豆腐柴组合物。
本发明的有益技术效果体现在：以中药配伍理论为基础，将豆腐柴叶与石斛、黄精、番木瓜、决明子合理配伍，通过醇提和水提分别提取原料中的不同有效成分，然后按照提取率比例将醇提物和水提物还原混合，制得豆腐柴组合物，经小鼠活体试验验证，本发明制备的豆腐柴组合物能够显著改善洛哌丁胺诱导的肠蠕动抑制，具有通便功能。
具体实施方式
下面结合具体的实施例，对本发明做进一步说明。本发明的特点和优点将随着描述而更清楚，但示例性的实施例仅仅用来说明本发明，并不对本发明的范围构成任何限制。
实施例1
1、原料混合：按照重量份称取豆腐柴叶15～20份、石斛5～7份、黄精3～5份、番木瓜1～3份、决明子1～3份，混合均匀后粉碎，制得混合原料粉末；
2、醇提物制备：在混合原料粉末中按照料液比1g：50mL加入无水乙醇，在25℃条件下搅拌浸提24h，过滤分离滤渣和滤液，滤渣干燥备用，滤液经浓缩、干燥，制得醇提物，醇提物提取率为17％；
3、水提物制备：在干燥后的滤渣中按照料液比1g：50mL加入蒸馏水，在80℃条件下搅拌提取2h，过滤取滤液，滤液经浓缩、干燥，制得水提物，水提物提取率为39％；
4、将醇提物和水提物按照重量比17：39还原混合，制得豆腐柴组合物。
实施例2
1、豆腐柴组合物通便功能验证试验分组：通便功能验证试验以成年雄性昆明小鼠为试验动物，试验分正常对照组、肠蠕动抑制模型组、豆腐柴组合物组3个组。
2、豆腐柴组合物通便功能验证试验方法：参考《保健食品检验与评价技术规范》中的通便功能检验方法，正常对照组和肠蠕动抑制模型组灌胃蒸馏水，豆腐柴组合物组按照360mg/kg/d的给药量灌胃豆腐柴组合物，灌胃7d后各试验组小鼠禁食不禁水16h，肠蠕动抑制模型组、豆腐柴组合物组采用洛哌丁胺作为造模药物建立小鼠肠蠕动抑制模型(墨汁推进率试验洛哌丁胺给药量为5mg/kg，排便试验洛哌丁胺给药量为10mg/kg)，正常对照组灌胃蒸馏水，以墨汁推进率、排黑便时间、5h排便颗粒数、5h排便重作为测定指标。
3、豆腐柴组合物通便功能验证试验结果：各试验组通便指标测定结果见表1。
表1各试验组通便指标测定结果
| 分组 | 墨汁推进率％ | 排黑便时间min | 5h排便颗粒数 | 5h排便重g |
| 正常对照组 | 72.71±6.12<sup>a</sup> | 101.23±9.39<sup>a</sup> | 60.27±6.15<sup>a</sup> | 1.23±0.21<sup>a</sup> |
| 肠蠕动抑制模型组 | 41.33±5.02 | 171.18±11.17 | 23.93±3.99 | 0.51±0.07 |
| 豆腐柴组合物组 | 59.89±6.01<sup>a</sup> | 139.22±10.18<sup>a</sup> | 45.62±6.52<sup>a</sup> | 0.92±0.34<sup>a</sup> |
注：a与肠蠕动抑制模型组相比有显著性差异，P＜0.05。
通便功能测定结果显示：肠蠕动抑制模型组墨汁推进率、排黑便时间、5h排便颗粒数、5h排便重四项指标与正常对照组相比均存在显著性差异，表明采用洛哌丁胺建立肠蠕动抑制模型成功；灌胃豆腐柴组合物试验组小鼠的墨汁推进率、排黑便时间、5h排便颗粒数、5h排便重四项指标与肠蠕动抑制模型组相比均存在显著性差异，根据通便功能的判定标准(5小时排便重量和排便颗粒数任一项结果阳性，同时墨汁推进率和排便时间任一项结果阳性，可判定该项试验结果阳性)，豆腐柴组合物能够显著改善洛哌丁胺诱导的肠蠕动抑制，具有通便功能。
以上所述仅是本发明的优选实施方式，应当指出，本发明的内容，对于本技术领域的普通技术人员来说，在不脱离本发明技术原理的前提下，还可以做出若干改进和变型，这些改进和变型也应视为本发明的保护范围。
Claims (2)
1.一种具有通便功能的豆腐柴组合物，其特征在于所述组合物包括：豆腐柴叶15～20份、石斛5～7份、黄精3～5份、番木瓜1～3份、决明子1～3份，以上份数均为重量份。
2.根据权利要求1所述的一种具有通便功能的豆腐柴组合物的制备方法，其特征在于包括以下步骤：
(1)原料混合：按照重量份称取豆腐柴叶15～20份、石斛5～7份、黄精3～5份、番木瓜1～3份、决明子1～3份，混合均匀后粉碎，制得混合原料粉末；
(2)醇提物制备：在混合原料粉末中按照料液比1g：50mL加入无水乙醇，在25℃条件下搅拌浸提24h，过滤分离滤渣和滤液，滤渣干燥备用，滤液经浓缩、干燥，制得醇提物；
(3)水提物制备：在干燥后的醇提物滤渣中按照料液比1g：50mL加入蒸馏水，在80℃条件下搅拌提取2h，过滤取滤液，滤液经浓缩、干燥，制得水提物；
(4)将醇提物和水提物按照提取率比例还原混合，制得豆腐柴组合物。
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| CN109007594A (zh) * | 2018-08-23 | 2018-12-18 | 合肥膳之纤生物科技有限公司 | 一种豆腐柴高纤面条及其制备方法 |
| CN109170669A (zh) * | 2018-09-13 | 2019-01-11 | 合肥膳之纤生物科技有限公司 | 一种豆腐柴果胶冻粉及其制备方法 |
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| CN109007594A (zh) * | 2018-08-23 | 2018-12-18 | 合肥膳之纤生物科技有限公司 | 一种豆腐柴高纤面条及其制备方法 |
| CN109170669A (zh) * | 2018-09-13 | 2019-01-11 | 合肥膳之纤生物科技有限公司 | 一种豆腐柴果胶冻粉及其制备方法 |
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