CN115068394B - Whitening toner, emulsion and face cream containing compound natural plant extracts - Google Patents
Whitening toner, emulsion and face cream containing compound natural plant extracts Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/9794—Liliopsida [monocotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention belongs to the technical field of skin care products, and particularly relates to whitening toner, emulsion and face cream with a compound natural plant extract. The invention provides a compound natural plant extract, which comprises a first plant extract and a second plant extract; the first plant extract comprises raspberry extract, jasmine extract, peppermint extract, purslane extract, chamomile extract, aloe kura extract and raspberry pomace extract; the second plant extract comprises a peony leaf extract, a peony root extract, a raspberry leaf extract, a raspberry young fruit extract and a coconut shell extract; the mass ratio of the first plant extract to the second plant extract is (1-3) (1.5-2.1). The compound natural plant extract provided by the invention has the technical effects of excellent oxidation resistance and tyrosinase activity resistance and pleasant pink visual effect.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to whitening toner, emulsion and face cream containing a group of compound natural plant extracts.
Background
The general pursuit of fair skin is not decayed, and the action mechanism of the whitening skin care product is to prevent the synthesis of tyrosinase, inhibit the activity of tyrosinase, accelerate the decomposition of tyrosinase, inhibit the shape of melanocytes and inhibit the generation and accumulation of skin melanin. According to the action mechanism of the whitening skin care product, the skin care product with the whitening effect is generally added with functional raw materials such as a melanin cytotoxicity agent, a tyrosinase activity inhibitor, a metabolic agent for metabolizing melanin and the like; some whitening skin care products such as reducing agent, opacifier and chemical stripping agent are added, and by adding the above substances, the whitening skin care products can inhibit the generation and activity of tyrosinase in skin, block the formation of melanin in skin, and interfere the biochemical reaction process of melanin generation and metabolism to realize skin whitening.
The efficacy raw materials added in the whitening skin care products sold in the market at present mainly comprise one or more of arbutin, kojic acid, ascorbic acid, cell growth factors and the like, and the whitening cosmetic containing the raw materials has a certain damage to the skin while having a whitening effect, and can easily produce the phenomena of color change, smell change and instability. If arbutin has high photosensitivity, the arbutin is easy to change color and unstable when added into the product in a large amount; kojic acid is liable to cause contact dermatitis when the addition amount is large; ascorbic acid is not beneficial to skin absorption, and is extremely easy to oxidize and change color when encountering heat and light, so that the whitening effect is lost; the cell growth factor has short shelf life and is not easy to preserve for a long time.
Moreover, the common whitening cosmetics have great potential safety hazards, because the effect of a plurality of whitening agents is closely related to the use concentration, in general, the higher the use concentration is, the lower the pH is, the more obvious the whitening effect is, but the more irritant is, and even permanent damage is caused to the skin when serious.
Along with the development of plant extraction technology, more and more plant extracts are applied to whitening functional cosmetics and become effective functional components in the cosmetics. However, the whitening effect is not satisfactory for various reasons.
Disclosure of Invention
The invention aims to provide whitening toner, emulsion and cream of a group of compound natural plant extracts, the compound natural plant extracts provided by the invention have excellent oxidation resistance and tyrosinase activity resistance, and the compound natural plant extracts provided by the invention are used as active components of whitening toner, whitening emulsion and whitening cream, so that the whitening toner, whitening emulsion and whitening cream with better whitening effect and better anti-aging effect can be obtained.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a compound natural plant extract, which comprises a first plant extract and a second plant extract; the first plant extract comprises raspberry extract, jasmine extract, peppermint extract, purslane extract, chamomile extract, aloe kura extract and raspberry pomace extract; the second plant extract comprises a peony leaf extract, a peony root extract, a raspberry leaf extract, a raspberry young fruit extract and a coconut shell extract; the mass ratio of the first plant extract to the second plant extract is (1-5) (0.001-0.025).
Preferably, the compound natural plant extract comprises the following components in parts by weight: 0.3 to 0.5 part of raspberry extract, 0.3 to 0.5 part of jasmine extract, 0.3 to 0.5 part of mint extract, 0.3 to 0.5 part of purslane extract, 0.3 to 0.5 part of chamomile extract, 0.3 to 0.5 part of aloe kukola extract, 1.5 to 2 parts of raspberry pomace extract, 0.003 to 0.005 part of peony leaf extract, 0.003 to 0.005 part of peony root extract, 0.003 to 0.005 part of raspberry leaf extract, 0.003 to 0.005 part of raspberry young fruit extract and 0.003 to 0.005 part of coconut coir extract.
Preferably, the compound natural plant extract comprises the following components in parts by weight: 0.3 to 0.5 part of raspberry extract, 0.3 to 0.5 part of jasmine extract, 0.3 to 0.5 part of mint extract, 0.3 to 0.5 part of purslane extract, 0.3 to 0.5 part of chamomile extract, 0.3 to 0.5 part of aloe kukola extract, 1.5 to 2 parts of raspberry pomace extract, 0.003 to 0.005 part of peony leaf extract, 0.003 to 0.005 part of peony root extract, 0.003 to 0.005 part of raspberry leaf extract, 0.003 to 0.005 part of raspberry young fruit extract and 0.003 to 0.005 part of coconut coir extract.
Preferably, the preparation method of the coconut shell extract comprises the following steps:
(1) Mixing the coconut shell with an extraction solvent, and sequentially carrying out ultrasonic treatment, homogenization treatment and solid-liquid separation to obtain an extraction solution; the extraction solvent comprises an organic solvent and water, wherein the volume fraction of the organic solvent in the extraction solvent is 50-70%;
(2) Evaporating the extracting solution until the volume fraction of the organic solvent is less than or equal to 5%, so as to obtain a sample loading solution;
(3) Carrying out dynamic adsorption on the sample loading liquid by using a macroporous adsorption resin column, and sequentially carrying out water washing and eluent desorption after saturated adsorption to obtain desorption liquid;
the macroporous adsorption resin is AB-8 macroporous adsorption resin;
the eluent is ethanol water solution;
(4) And removing the eluent in the desorption liquid to obtain the purified cocoanut phenol compound.
The invention provides whitening toner, which comprises a toner base component and a natural plant extract active component, wherein the natural plant extract active component is a compound natural plant extract according to the technical scheme; the mass ratio of the base component of the toner to the active component of the natural plant extract is (94.9-99) (1-5.1); the toner base component comprises glycerin, sodium hyaluronate, water and ethanol.
Preferably, the whitening toner comprises the following components in parts by mass: 3.5 to 4.5 parts of glycerin, 0.05 to 0.15 part of sodium hyaluronate, 1 to 5.1 parts of natural plant extract active components, 89 to 93.5 parts of water and 0.5 to 1.5 parts of ethanol.
The invention provides a whitening emulsion, which comprises an emulsion basic component and a natural plant extract active component, wherein the natural plant extract active component is a compound natural plant extract according to any one of claims 1 to 3; the mass ratio of the emulsion basic component to the natural plant extract active component is (94.9-99): 1-5.1; the emulsion base component comprises caprylic capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, simethicone, cyclopentadimethicone, liquid paraffin, squalane, glycerol, propylene glycol, carbomer, allantoin and water.
Preferably, the whitening emulsion comprises the following components in parts by mass: 3 to 4.5 parts of caprylic/capric triglyceride, 1 to 2 parts of cetostearyl alcohol, 1 to 2 parts of cetostearyl glucoside, 1 to 2.5 parts of simethicone, 0.5 to 1.5 parts of cyclopentadimethicone, 1 to 2.5 parts of liquid paraffin, 2 to 4.5 parts of squalane, 1 to 3.5 parts of glycerol, 4 to 6 parts of propylene glycol, 0.1 to 3 parts of carbomer, 0.1 to 0.5 part of allantoin, 1 to 5.1 parts of natural plant extract active components and 72 to 77.5 parts of water.
The invention provides whitening cream, which comprises a cream basic component and a natural plant extract active component, wherein the natural plant extract active component is the compound natural plant extract of any one of claims 1-3; the mass ratio of the basic component of the face cream to the active component of the natural plant extract is (94.9-99): 1-5.1; the base component of the cream comprises caprylic capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, simethicone, cyclopentadimethicone, liquid paraffin, squalane, vaseline, shea butter, glycerol, propylene glycol, carbomer, allantoin and water.
Preferably, the whitening cream comprises the following components in parts by mass: 5 to 7 parts of caprylic/capric triglyceride, 1 to 2 parts of cetostearyl alcohol, 2 to 4 parts of cetostearyl glucoside, 3 to 5 parts of simethicone, 0.5 to 2 parts of cyclopentamethylsilicone, 3 to 10 parts of liquid paraffin, 5 to 8 parts of squalane, 3 to 5 parts of Vaseline, 1 to 3 parts of shea butter, 3.75 to 5 parts of glycerol, 4 to 8 parts of propylene glycol, 0.4 to 6 parts of carbomer, 0.3 to 0.8 part of allantoin, 1 to 5.1 parts of natural plant extract active components and 31 to 67.5 parts of water.
The invention provides a compound natural plant extract, which comprises a first plant extract and a second plant extract; the first plant extract comprises raspberry extract, jasmine extract, peppermint extract, purslane extract, chamomile extract, aloe kura extract and raspberry pomace extract; the second plant extract comprises a peony leaf extract, a peony root extract, a raspberry leaf extract, a raspberry young fruit extract and a coconut shell extract; the mass ratio of the first plant extract to the second plant extract is (1-5) (0.001-0.025). The compound natural plant extract provided by the invention has the technical effects of excellent oxidation resistance and tyrosinase activity resistance, and can be used as active components of whitening toner, whitening emulsion and whitening cream, and the whitening toner, the whitening emulsion and the whitening cream simultaneously have good whitening effect and good anti-aging effect.
The invention provides whitening toner, which comprises a toner base component and a natural plant extract active component, wherein the natural plant extract active component is a compound natural plant extract according to the technical scheme; the mass ratio of the base component of the toner to the active component of the natural plant extract is (94.9-99) (1-5.1); the toner base component comprises glycerin, sodium hyaluronate water and ethanol. The whitening toner provided by the invention takes the compound natural plant extract as an active component, and simultaneously adjusts and controls the types of the water-based components and the mass ratio of the basic components to the active components of the natural plant extract to be (94.9-99): 1-5.1), so that the toner with proper pH value and viscosity can be obtained, and the toner has better whitening and anti-aging effects. The results of the examples show that the pH value of the whitening toner provided by the invention is 4.06, the DPPH free radical clearance rate is 53.82%, and the anti-tyrosinase activity is 14.54%.
The invention provides a whitening emulsion, which comprises an emulsion basic component and a natural plant extract active component, wherein the natural plant extract active component is a compound natural plant extract according to any one of claims 1 to 3; the mass ratio of the emulsion basic component to the natural plant extract active component is (94.9-99): 1-5.1; the emulsion base component comprises caprylic capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, simethicone, cyclopentadimethicone, liquid paraffin, squalane, glycerol, propylene glycol, carbomer, allantoin and water. The whitening emulsion provided by the invention takes the compound natural plant extract as an active component, and simultaneously adjusts and controls the types of basic components of the emulsion and the mass ratio of the basic components to the active components of the natural plant extract to be (94.9-99) (1-5.1), so that the emulsion with proper pH value and viscosity can be obtained, and the emulsion has better whitening and anti-aging effects. The results of the examples show that the whitening emulsion provided by the invention has a pH value of 4.16, a viscosity of 880 mpa.s, a DPPH free radical clearance of 61.38% and an anti-tyrosinase activity of 13.73%.
The invention provides whitening cream, which comprises a cream basic component and a natural plant extract active component, wherein the natural plant extract active component is the compound natural plant extract of any one of claims 1-3; the mass ratio of the basic component of the face cream to the active component of the natural plant extract is (94.9-99): 1-5.1; the base component of the cream comprises caprylic capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, simethicone, cyclopentadimethicone, liquid paraffin, squalane, vaseline, shea butter, glycerol, propylene glycol, carbomer, allantoin and water. The whitening cream provided by the invention takes the compound natural plant extract as an active component, and simultaneously adjusts and controls the types of basic components of the cream and the mass ratio of the basic components to the active components of the natural plant extract to be (94.9-99) (1-5.1), so that the cream with proper pH value and viscosity can be obtained, and the cream has better whitening and anti-aging effects. The results of the examples show that the whitening cream provided by the invention has the pH value of 4.18, the viscosity of 3920 mpa.s, the DPPH free radical clearance of 49.73% and the anti-tyrosinase activity of 24.28%.
Drawings
FIG. 1 is a physical diagram of the whitening toner prepared in example 1 of the present invention;
fig. 2 is a physical view of the toner prepared in comparative example 1 of the present invention.
Fig. 3 is a physical diagram of the whitening emulsion prepared in example 2 of the present invention;
FIG. 4 is a physical diagram of the emulsion prepared in comparative example 2 of the present invention;
fig. 5 is a physical diagram of the whitening cream prepared in example 3 of the present invention;
FIG. 6 is a physical view of the cream of comparative example 3 of the present invention;
FIG. 7 is a photograph of the original color difference of the emulsion prepared in comparative example 4 of the present invention;
FIG. 8 is a photograph showing the color difference of the emulsion prepared in comparative example 4 of the present invention after irradiation at normal temperature, 4℃and 60℃and exposure to ultraviolet rays;
FIG. 9 is a physical diagram of the emulsion prepared in comparative example 4 of the present invention.
Detailed Description
The invention provides a compound natural plant extract which comprises a first plant extract and a second plant extract; the first plant extract comprises raspberry extract, jasmine extract, peppermint extract, purslane extract, chamomile extract, aloe kura extract and raspberry pomace extract; the second plant extract comprises a peony leaf extract, a peony root extract, a raspberry leaf extract, a raspberry young fruit extract and a coconut shell extract; the mass ratio of the first plant extract to the second plant extract is (1-5) (0.001-0.025).
In the present invention, all preparation materials/components are commercially available products well known to those skilled in the art unless specified otherwise.
In the present invention, the raspberry extract is a liquid.
In the present invention, the raspberry extract is preferably purchased from: and the product model is YH-51111 of the Shang macro biotechnology Co., ltd.
In the present invention, the jasmine flower extract is a liquid.
In the present invention, the jasmine extract is preferably purchased from: and the product model is YH-51095 of the Shang macro biotechnology Co., ltd.
In the present invention, the mint extract is a liquid.
In the present invention, the mint extract is preferably purchased from: the product model is YH-51205 of the Shang macro biotechnology Co., ltd
In the invention, the purslane extract is liquid.
In the present invention, the purslane extract is preferably purchased from: and the product model is YH-52241 of the Shang macro biotechnology Co., ltd.
In the present invention, the chamomile extract is a liquid.
In the present invention, the chamomile extract is preferably purchased from: and the product model is YH-51022 of the Shang macro biotechnology Co., ltd.
In the present invention, the aloe vera extract is a liquid.
In the present invention, the aloe vera extract is preferably purchased from: the product model of the Zhou city exhibition macro biotechnology Co., ltd is YH-51003.
In the invention, the peony leaf extract is solid powder.
In the present invention, the peony leaf extract preferably refers to: the best process parameters described in "Chunyu Wang, nana Li, liyang Wu, libin Xia, zhiyong Hu, xiaojun Li, zhican Qu. Jing Yang. Optimization ofultrasound-homogenization combined extraction ofphenolics in peony roots and leave.food Science and Technology,2022.42:e108621.", were prepared: taking peony leaf solid powder as a raw material, carrying out ultrasonic treatment for 60min, carrying out ultrasonic power 250W and ultrasonic power 250 r/min for 5min, collecting supernatant, concentrating and drying to obtain the peony leaf extract. The total flavone content is 27.20mg rutin/g dw.
In the invention, the peony root extract is solid powder.
In the present invention, the peony root extract is preferably prepared with reference to the optimal process parameters described in "Chunyu Wang, nana Li, liyang Wu, libin Xia, zhiyong Hu, xaojun Li, zhican Qu, jing Yang. Optimization ofultrasound-homogenization combined extraction ofphenolics in peony roots and leave, food Science and Technology,2022.42:e108621. Taking peony root solid powder as a raw material, carrying out ultrasonic treatment for 80min, carrying out ultrasonic power 250W and ultrasonic power 250 r/min for 5min, collecting supernatant, concentrating and drying to obtain the peony root extract. The total flavone content is 41.83mg rutin/g dw.
In the present invention, the raspberry leaf extract is a solid powder.
In the present invention, the raspberry leaf extract is preferably described in "Han Gongjuan, yang Jing, chen Xiao, chen Chen, cui Jingyan, liu Yongping, wu Yanhui. The main antioxidant substance extraction process optimization study in raspberry leaves [ J ]. University of Yunnan (natural science edition), 2018,40 (2): the preparation is carried out according to the optimal technological parameters described in 321-331': the raspberry leaf extract is prepared by taking raspberry leaf powder as a raw material, extracting the raspberry leaf powder with ethanol concentration of 60% at a ratio of 1:40 for 30min, collecting supernatant, concentrating and drying. The total flavone content is 51.74mg rutin/g dw.
In the invention, the raspberry young fruit extract is solid powder.
In the present invention, the raspberry young fruit tree extract is preferably described in "Wu Yanhui, yang Jing, proto-qian, li Juanling, mei Xuefeng, li-xiong, headland Hua Mei, raspberry dry fruit crude flavone purification and activity study, university of yunnan (natural science edition), 2016, 38 (4): the best process parameters described in 676-682 were prepared: the raspberry young fruits are used as raw materials, and the feed liquid ratio is 1:40, ultrasonic time 42.30min, leaching temperature 80 ℃, ethanol concentration 52% extracting, rotary evaporating to remove ethanol, loading supernatant liquid serving as loading liquid to XDA-6 macroporous resin at a flow rate of 6BV/h (1 BV is 1 column volume), eluting with 60% ethanol serving as eluent at a flow rate of 4BV/h, eluting with eluent amount of 5BV, collecting eluent, concentrating, and drying to obtain the raspberry young fruit extract. The total flavone content is 350.8mg rutin/g dw.
In the present invention, the raspberry pomace extract is a liquid.
In the present invention, the raspberry pomace extract is preferably prepared by referring to the best process parameters described in "change of polyphenols during raspberry fruit ripening and extraction and application thereof, cui Jingyan, university of middle north, 2019 [ D ]": fresh raspberry pomace is taken as a raw material, the feed liquid ratio is 1:50, the ethanol concentration is 75%, the pH of an extracting agent is 3, the temperature is 60 ℃, the time is 30min, the ultrasonic power is 150W, the extracting solution is concentrated into concentrated solution with the anthocyanin concentration of 0.2mg/mL by rotary evaporation, after the concentrated solution is adsorbed by AB-8 macroporous resin for 4 hours, the impurities such as polysaccharide, protein and the like are eluted by distilled water with the pH of 3, then the anthocyanin is eluted by 45% ethanol with the pH of 3, and the eluent is collected and concentrated to obtain the raspberry pomace extract (liquid). The total flavone content is 4.16mg rutin/mL, and the anthocyanin content is 0.75mg procyanidin-3-O-glucoside/mL.
In the present invention, the coconut husk extract is a solid powder.
In the invention, the preparation method of the coconut shell extract comprises the following steps: 60% acetone is used as an extraction solvent, the feed liquid ratio is 1:5, the ultrasonic temperature is 80 ℃, the time is 80min and the power is 225W, then the mixture is homogenized for 5min at 10,000r/min, after alcohol is removed by rotary evaporation, the supernatant liquid is used as a sample liquid, an AB-8 macroporous resin column (with the height to diameter ratio of 15:3) is used for sample loading at the speed of 5BV/h, 60% ethanol is used for eluting, when the eluting speed is 0.5BV/h, the impurity eluting amount of distilled water is 2BV, the impurity eluting amount is 4BV, and the eluent is collected, concentrated and dried to obtain the coconut shell extract. The total flavone content is 1255.41 +/-42.49 mg rutin/g dw.
In the invention, the compound natural plant extract preferably comprises the following components in parts by mass: 0.3 to 0.5 part of raspberry extract, 0.3 to 0.5 part of jasmine extract, 0.3 to 0.5 part of mint extract, 0.3 to 0.5 part of purslane extract, 0.3 to 0.5 part of chamomile extract, 0.3 to 0.5 part of aloe kukola extract, 1.5 to 2 parts of raspberry pomace extract, 0.003 to 0.005 part of peony leaf extract, 0.003 to 0.005 part of peony root extract, 0.003 to 0.005 part of raspberry leaf extract, 0.003 to 0.005 part of raspberry young fruit extract and 0.003 to 0.005 part of coconut coir extract.
In the invention, the compound natural plant extract more preferably comprises the following components in parts by mass: 0.4 to 0.5 part of raspberry extract, 0.4 to 0.5 part of jasmine extract, 0.4 to 0.5 part of mint extract, 0.4 to 0.5 part of purslane extract, 0.4 to 0.5 part of chamomile extract, 0.4 to 0.5 part of aloe kukola extract, 1.8 to 2 parts of raspberry pomace extract, 0.004 to 0.0055 part of peony leaf extract, 0.004 to 0.0055 part of peony root extract, 0.004 to 0.0055 part of raspberry leaf extract, 0.004 to 0.0055 part of raspberry young fruit extract and 00.004 to 0.0055 part of coconut shell extract.
In the invention, the compound natural plant extract further preferably comprises the following components in parts by mass: 0.5 part of raspberry extract, 0.5 part of jasmine extract, 0.5 part of mint extract, 0.5 part of portulaca oleracea extract, 0.5 part of chamomile extract, 0.5 part of aloe kura extract, 2 parts of raspberry fruit residue extract, 0.005 part of peony leaf extract, 0.005 part of peony root extract, 0.005 part of raspberry leaf extract, 0.005 part of raspberry young fruit extract and 0.005 part of coconut shell extract.
The preparation method of the compound natural plant extract has no special requirement, and the components are uniformly mixed.
The invention provides whitening toner, which comprises a toner base component and a natural plant extract active component, wherein the natural plant extract active component is a compound natural plant extract according to the technical scheme; the mass ratio of the base component of the toner to the active component of the natural plant extract is (94.9-99) (1-5.1); the toner base component comprises glycerin, sodium hyaluronate, water and ethanol.
In the present invention, the water is preferably distilled water.
In the invention, the mass ratio of the toner water base component to the natural plant extract active component (94.9-99) (1-5.1), preferably 94.975:5.025.
In the invention, the whitening toner preferably comprises the following components in parts by mass: 3.5 to 4.5 parts of glycerin, 0.05 to 0.15 part of sodium hyaluronate, 1 to 5.1 parts of natural plant extract active components, 89 to 93.5 parts of water and 0.5 to 1.5 parts of ethanol.
In the invention, the whitening toner preferably comprises the following components in parts by mass: 3.5 to 4.5 parts of glycerin, 0.05 to 0.15 part of sodium hyaluronate, 0.3 to 0.5 part of raspberry extract, 0.3 to 0.5 part of jasmine extract, 0.3 to 0.5 part of peppermint extract, 0.3 to 0.5 part of purslane extract, 0.3 to 0.5 part of chamomile extract, 0.3 to 0.5 part of cursora aloe extract, 0.003 to 0.005 part of peony leaf extract, 0.003 to 0.005 part of peony root extract, 0.003 to 0.005 part of raspberry leaf extract, 0.003 to 0.005 part of raspberry young fruit extract, 1.5 to 2 parts of raspberry residue extract, 0.003 to 0.005 part of coconut shell extract, 89 to 90 parts of water and 0.5 to 1.5 parts of ethanol.
In the invention, the whitening toner more preferably comprises the following components in parts by mass: 4 parts of glycerin, 0.1 part of sodium hyaluronate, 0.5 part of raspberry extract, 0.5 part of jasmine extract, 0.5 part of mint extract, 0.5 part of purslane extract, 0.5 part of chamomile extract, 0.5 part of aloe kukola extract, 0.005 part of peony leaf extract, 0.005 part of peony root extract, 0.005 part of raspberry leaf extract, 0.005 part of raspberry young fruit extract, 2 parts of raspberry fruit residue extract, 0.005 part of coconut shell extract, 89.875 parts of water and 1 part of ethanol.
The invention also provides a preparation method of the whitening toner, which preferably comprises the following steps:
mixing glycerol, sodium hyaluronate and natural plant extract active components to obtain a first water phase;
mixing water and ethanol to obtain a second water phase;
and mixing the first water phase and the second water phase to obtain the whitening toner.
In the present invention, the temperature at which the glycerin, sodium hyaluronate, and natural plant extract active ingredient are mixed is preferably 70 to 80 ℃, more preferably 80 ℃.
In the present invention, the incubation time for mixing the glycerin, sodium hyaluronate, and natural plant extract active ingredient is preferably 15 to 25 minutes, more preferably 20 minutes.
In the present invention, the temperature at which the water and ethanol are mixed is preferably room temperature.
In the present invention, the temperature of the first aqueous phase and the second aqueous phase is preferably room temperature.
The invention provides a whitening emulsion, which comprises an emulsion basic component and a natural plant extract active component, wherein the natural plant extract active component is the compound natural plant extract according to the technical scheme; the mass ratio of the emulsion basic component to the natural plant extract active component is (96.95-97): 3-3.05; the emulsion base component comprises caprylic capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, simethicone, cyclopentadimethicone, liquid paraffin, squalane, glycerol, propylene glycol, carbomer, allantoin and water.
In the present invention, the mass ratio of the emulsion base component and the natural plant extract active component is (94.9-99): 1-5.1, preferably 94.975:5.025.
In the invention, the whitening emulsion preferably comprises the following components in parts by mass: 3 to 4.5 parts of caprylic/capric triglyceride, 1 to 2 parts of cetostearyl alcohol, 1 to 2 parts of cetostearyl glucoside, 1 to 2.5 parts of simethicone, 0.5 to 1.5 parts of cyclopentadimethicone, 1 to 2.5 parts of liquid paraffin, 2 to 4.5 parts of squalane, 1 to 3.5 parts of glycerin, 4 to 6 parts of propylene glycol, 0.1 to 3 parts of carbomer, 0.1 to 0.5 part of allantoin, 1 to 5.1 parts of natural plant extract active components and 72 to 77.5 parts of water.
In the invention, the whitening emulsion more preferably comprises the following components in parts by mass: 3 to 4.5 parts of caprylic triglyceride, 1 to 2 parts of cetostearyl alcohol, 1 to 2 parts of cetostearyl glucoside, 1 to 2.5 parts of simethicone, 0.5 to 1.5 parts of cyclopentadimethicone, 1 to 2.5 parts of liquid paraffin, 2 to 4.5 parts of squalane, 1 to 3.5 parts of glycerin, 4 to 6 parts of propylene glycol, 0.1 to 3 parts of carbomer, 0.1 to 0.5 part of allantoin, 0.3 to 0.5 part of raspberry extract, 0.3 to 0.5 part of jasmine extract, 0.3 to 0.5 part of mint extract, 0.3 to 0.5 part of purslane extract, 0.3 to 0.5 part of chamomile extract, 0.3 to 0.5 part of kura aloe extract, 0.003 to 0.005 part of peony leaf extract, 0.003 to 0.005 part of peony root extract, 0.003 to 0.003 part of raspberry extract, 0.005 to 0.72 part of raspberry extract and 2.005 to 2.005 parts of water-borne raspberry extract.
In the invention, the whitening emulsion further preferably comprises the following components in parts by mass: 4 parts of caprylic/capric triglyceride, 1.5 parts of cetostearyl alcohol, 1.5 parts of cetostearyl glucoside, 2 parts of simethicone, 1 part of cyclopentadimethicone, 2 parts of liquid paraffin, 3 parts of squalane, 2.5 parts of glycerin, 5 parts of propylene glycol, 0.2 part of carbomer, 0.2 part of allantoin, 0.5 part of raspberry extract, 0.5 part of jasmine extract, 0.5 part of peppermint extract, 0.5 part of purslane extract, 0.5 part of chamomile extract, 0.5 part of aloe kurara extract, 0.005 part of peony leaf extract, 0.005 part of peony root extract, 0.005 part of raspberry leaf extract, 0.005 part of raspberry young fruit extract, 2 parts of raspberry residue extract, 0.005 part of coconut coir extract and 72.075 parts of water.
The invention also provides a preparation method of the whitening emulsion, which preferably comprises the following steps:
mixing caprylic/capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, simethicone, cyclopentadimethicone, liquid paraffin and squalane to obtain oil phase;
mixing glycerol, propylene glycol, carbomer, allantoin, natural plant extract active ingredient and water to obtain water phase;
And mixing the oil phase and the water phase to obtain the whitening emulsion.
In the present invention, the temperature at which the caprylic/capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, dimethicone, cyclopentadimethicone, liquid paraffin and squalane are mixed is preferably 70 to 80 ℃, more preferably 80 ℃.
The invention has no special requirement on the heat preservation time of mixing the caprylic/capric triglyceride, the cetostearyl alcohol, the cetostearyl glucoside, the simethicone, the cyclopentadimethicone, the liquid paraffin and the squalane, and can completely dissolve the components of the oil phase.
In the present invention, the temperature at which the glycerin, propylene glycol, carbomer, allantoin, natural plant extract active ingredient and water are mixed is preferably 85 to 90 ℃, more preferably 90 ℃.
The invention has no special requirement on the heat preservation time of mixing the glycerol, the propylene glycol, the carbomer, the allantoin, the active group of the natural plant extract and the water, and can completely dissolve the components of the water phase.
In the present invention, the temperature at which the oil phase and the water phase are mixed is preferably 80 to 90 ℃.
In the present invention, the mixing of the oil phase and the water phase is preferably performed in a high-speed disperser.
In the present invention, the mixing of the oil phase and the water phase is performed under stirring, and the stirring speed at the time of mixing the oil phase and the water phase is preferably 4500 to 5500r/min, more preferably 5000r/min.
In the present invention, the heat-preserving time for mixing the oil phase and the water phase is preferably such that the oil phase and the water phase are completely emulsified to obtain an emulsion product.
The invention provides whitening cream which comprises a cream basic component and a natural plant extract active component, wherein the natural plant extract active component is a compound natural plant extract according to the technical scheme; the mass ratio of the basic component of the face cream to the active component of the natural plant extract is (94.9-99): 1-5.1; the base component of the cream comprises caprylic capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, simethicone, cyclopentadimethicone, liquid paraffin, squalane, vaseline, shea butter, glycerol, propylene glycol, carbomer, allantoin and water.
In the present invention, the mass ratio of the base component of the face cream to the active component of the natural plant extract is (94.9-99): 1-5.1, preferably 94.975:5.025.
In the invention, the whitening cream preferably comprises the following components in parts by mass: 5 to 7 parts of caprylic/capric triglyceride, 1 to 2 parts of cetostearyl alcohol, 2 parts of cetostearyl glucoside, 3 to 5 parts of simethicone, 0.5 to 2 parts of cyclopentadimethicone, 3 to 10 parts of liquid paraffin, 5 to 8 parts of squalane, 3 to 5 parts of Vaseline, 1 to 3 parts of shea butter, 3.75 to 5 parts of glycerol, 4 to 8 parts of propylene glycol, 0.4 to 6 parts of carbomer, 0.3 to 0.8 part of allantoin, 1 to 5.1 parts of natural plant extract active components and 31 to 67.5 parts of water.
In the invention, the whitening cream more preferably comprises the following components in parts by mass: 5 to 7 parts of caprylic triglyceride, 1 to 2 parts of cetostearyl alcohol, 2 parts of cetostearyl glucoside, 3 to 5 parts of simethicone, 0.5 to 2 parts of cyclopentadimethicone, 3 to 10 parts of liquid paraffin, 5 to 8 parts of squalane, 3 to 5 parts of Vaseline, 1 to 3 parts of shea butter, 3.75 to 5 parts of glycerin, 4 to 8 parts of propylene glycol, 0.4 to 6 parts of carbomer, 0.3 to 0.8 part of allantoin, 0.3 to 0.5 part of raspberry extract, 0.3 to 0.5 part of jasmine flower extract, 0.3 to 0.5 part of mint extract, 0.3 to 0.5 part of horseradish seed extract, 0.3 to 0.5 part of chamomile extract, 0.3 to 0.5 part of cursora extract, 0.3 to 0.5 part of tree peony leaf extract, 0.003 to 0.005 part of root extract, 0.003 to 0.003 part of raspberry leaf extract, 0.003 to 0.005 part of raspberry residue and 0.64 to 1.005 part of tree fruit residue extract.
In the invention, the whitening cream further preferably comprises the following components in parts by mass: 5.25 parts of caprylic/capric triglyceride, 2 parts of cetostearyl alcohol, 2 parts of cetostearyl glucoside, 3 parts of simethicone, 1 part of cyclopentadimethicone, 3 parts of liquid paraffin, 5 parts of squalane, 3 parts of Vaseline, 1 part of shea butter, 3.75 parts of glycerin, 5 parts of propylene glycol, 0.4 part of carbomer, 0.4 part of allantoin, 0.5 part of raspberry extract, 0.5 part of jasmine extract, 0.5 part of mint extract, 0.5 part of purslane extract, 0.5 part of chamomile extract, 0.5 part of aloe kura extract, 0.005 part of peony leaf extract, 0.005 part of peony root extract, 0.005 part of raspberry leaf extract, 0.005 part of raspberry young fruit extract, 2 parts of raspberry residue extract, 0.005 part of coconut shell extract and 60.175 parts of water.
The invention also provides a preparation method of the whitening cream, which preferably comprises the following steps:
mixing caprylic/capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, simethicone, cyclopentadimethicone, liquid paraffin, squalane, vaseline and shea butter to obtain oil phase;
mixing glycerol, propylene glycol, carbomer, allantoin, natural plant extract active components and water to obtain water phase;
And mixing the oil phase and the water phase to obtain the whitening emulsion.
In the present invention, the temperature at which the caprylic/capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, simethicone, cyclopentadimethicone, liquid paraffin, squalane, vaseline and shea butter are mixed is preferably 70 to 80 ℃, more preferably 80 ℃.
The invention has no special requirement on the heat preservation time of mixing the caprylic/capric triglyceride, the cetostearyl alcohol, the cetostearyl glucoside, the simethicone, the cyclopentadimethicone, the liquid paraffin, the squalane, the Vaseline and the shea butter, and can completely dissolve the components of the oil phase.
In the present invention, the temperature at which the glycerin, propylene glycol, carbomer, allantoin, natural plant extract active ingredient and water are mixed is preferably 85 to 90 ℃, more preferably 90 ℃.
The invention has no special requirement on the heat preservation time of mixing the glycerol, the propylene glycol, the carbomer, the allantoin, the active components of the natural plant extract and the water, and can completely dissolve the components of the water phase.
In the present invention, the temperature at which the oil phase and the water phase are mixed is preferably 80 to 90 ℃.
In the present invention, the mixing of the oil phase and the water phase is preferably performed in a high-speed disperser.
In the present invention, the mixing of the oil phase and the water phase is performed under stirring, and the stirring speed at the time of mixing the oil phase and the water phase is preferably 4500 to 5500r/min, more preferably 5000r/min.
In the invention, the heat preservation time for mixing the oil phase and the water phase is preferably the time for completely emulsifying the oil phase and the water phase to obtain a cream product.
The above technical solutions provided by the present invention are described in detail below with reference to the drawings and examples for further illustrating the present invention, but they should not be construed as limiting the scope of the present invention.
In the present invention, the specifications and manufacturers of the raw materials used in the examples are shown in Table 1, and the models and manufacturers of the instruments and equipment used in the examples are shown in Table 2.
Table 1 specification and manufacturer of raw materials used in the examples
Table 2 model and manufacturer of the instruments and equipment used in the examples
Example 1
The compositions of the oil phase and the water phase in the whitening toner prepared in example 1 are shown in table 3:
TABLE 3 aqueous phase composition in whitening toner prepared in example 1
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The preparation method of the whitening toner provided in the embodiment 1 comprises the following steps:
Uniformly mixing the components of the first water phase, completely dissolving at 80 ℃, preserving heat for 20min, and cooling to room temperature to obtain a first water phase; mixing the components of the second aqueous phase to obtain a second aqueous phase; and uniformly mixing the first water phase and the second water phase to obtain the whitening toner, wherein the physical diagram is shown in figure 1, and the whitening toner is stored for standby.
Comparative example 1
The compositions of the oil phase and the water phase in the toner prepared in comparative example 1 are shown in table 4:
table 4 aqueous phase composition in the toner prepared in comparative example 1
The preparation method is the same as that of example 1, and the physical diagram of the prepared toner is shown in fig. 2 and is stored for standby.
Example 2
The compositions of the oil phase and the water phase in the whitening emulsion prepared in example 2 are shown in table 5:
TABLE 5 oil phase and Water phase compositions in whitening emulsion prepared in example 2
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The coconut husk extract was prepared in the same way as in example 1;
the preparation method of the whitening emulsion water provided in the embodiment 2 comprises the following steps:
completely dissolving the components of the oil phase at 80 ℃ to obtain the oil phase; and (3) completely melting all the components of the water phase at 90 ℃ to obtain the water phase, then pouring the hot oil phase into the water phase at a rotating speed of 5000r/min by using a high-speed dispersing machine, and rapidly emulsifying until the two phases are completely emulsified and fused to obtain the whitening emulsion, wherein a physical diagram is shown in figure 3, and preserving for later use.
Comparative example 2
The compositions of the oil phase and the water phase in the emulsion prepared in comparative example 2 are shown in table 6:
TABLE 6 oil phase and Water phase compositions in the emulsions prepared in comparative example 2
The preparation method is the same as that of example 2, and the physical diagram of the prepared emulsion is shown in fig. 4 and is stored for standby.
Example 3
The compositions of the oil phase and the water phase in the whitening cream prepared in example 3 are shown in table 7:
TABLE 7 oil phase and Water phase compositions in whitening emulsion prepared in example 3
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The coconut husk extract was prepared in the same way as in example 1;
the preparation method of the whitening cream provided in the embodiment 3 comprises the following steps:
completely dissolving the components of the oil phase at 80 ℃ to obtain the oil phase; and (3) completely melting all the components of the water phase at 90 ℃ to obtain the water phase, then pouring the hot oil phase into the water phase at a rotating speed of 5000r/min by using a high-speed dispersing machine, and rapidly emulsifying until the two phases are completely emulsified and fused to obtain the whitening cream, wherein a physical diagram is shown in figure 5, and storing for later use.
Comparative example 3
The compositions of the oil phase and the water phase in the cream prepared in comparative example 3 are shown in table 8:
TABLE 8 oil phase and Water phase compositions in the creams prepared in comparative example 3
The preparation method is the same as that of example 3, and the prepared facial cream physical diagram is shown in fig. 6 and is stored for standby.
Comparative example 4
The compositions of the oil phase and the water phase in the emulsion prepared in comparative example 4 are shown in table 9:
TABLE 9 oil and Water phase compositions in the emulsions prepared in comparative example 4
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The preparation method is the same as that of example 2, and the physical diagram of the prepared emulsion is shown in fig. 9 and is stored for standby.
Test example 1
Color difference detection of the toner prepared in examples 1 to 3 and comparative examples 1 to 4
Compared with comparative examples 1 to 3, the toner, emulsion and cream prepared in examples 1 to 3 were tinted by adding raspberry pomace extract, the raspberry pomace extract was added in an amount to replace part of distilled water in the aqueous phase, the raspberry pomace extract was a bioflavonoid substance, the flavonoid substance had free radical scavenging ability and antioxidant ability, the raspberry pomace extract was added to enhance the free radical scavenging and antioxidant ability of the toner, emulsion and cream, and the raspberry pomace extract was used for tinting, was prepared as clear pale pink, and was used for neutralization tinting for the emulsion of the colored plant extract added later.
To verify that the color of the emulsion was affected by the use of the blue-green pigment, the emulsion prepared in comparative example 4 was added to each of four transparent split boxes for a long period of time, and the emulsion was exposed to ultraviolet irradiation in a room temperature, 4℃refrigerator, and 60℃oven-drying box, respectively. The emulsion photograph before treatment is shown in FIG. 7, the emulsion photograph after treatment for 14 days is shown in FIG. 8, and the result of the measurement by the color difference meter is shown in Table 10.
In table 10, the larger the luminance value L is, the brighter the measured object is, and the smaller the luminance value L is, the darker the measured object is; the greater the red-green value a, the more the object color is biased toward red, and conversely, the greater the green and yellow Lan Zhi b, the more the object color is biased toward yellow. Color is expressed as a (+red; -green), b (+yellow; -blue) and L (100=white; 0=black) according to CIELAB color scale (references MasekA, latos M, piotrowska M, et al potential ofquercetin as an effective natural antioxidant and indicator for packaging materials.food Packaging and Shelf Life [ J ]2018,1651-58.)
Table 10 color difference change at 60 c of the emulsion prepared in comparative example 4
By detecting the color difference change of the emulsion prepared in comparative example 4, it was found that the emulsion was significantly yellowish and blackish after 7 days of high temperature treatment, and the emulsion was in a liquid form after 14 days of high temperature treatment with very thin consistency, and the color was blackish and blackish. The color difference detector shows that the color of the emulsion is changed greatly when the emulsion is placed at a high temperature of 60 ℃ for two weeks, the color and the morphology of the emulsion can be seen to be changed greatly, the texture of the emulsion is liquid, the color is blackened and yellow, and the numerical value of the emulsion is detected to be changed greatly by the color difference detector, so that the damage of the raspberry fruit residue extract in the emulsion is proved at the high temperature.
Test example 2
Determination of pH values of the toner, emulsion and cream prepared in examples 1 to 3 and comparative examples 1 to 3
The pH was measured using a pH meter, the pH meter was placed horizontally, the composite electrode of the pH meter was washed with distilled water, blotted dry with filter paper, and the composite electrode was kept dry, while taking care that the glass electrode could not be broken. The pH meter was calibrated and the composite electrode of the pH meter was inserted into the calibration solution at pH6.86, positioning the instrument to reading 6.86 until stable. The composite electrode was washed with distilled water and blotted dry with filter paper. The calibrated buffer solution is generally used for the first time with a pH of 6.86, and for the second time with a buffer solution which is close to the pH value of the measured solution, and the pH value of the buffer solution should be selected to be 4.00 because the measured solution is acidic. The composite electrode of the pH meter was then inserted into a calibration solution at pH4.00 to position the instrument to reading 4.00 until stable. The composite electrode was washed with distilled water and blotted dry with filter paper.
The toner prepared in example 1, the toner prepared in comparative example 1, the emulsion prepared in example 2, the emulsion prepared in comparative example 2, the cream prepared in example 3 and the cream prepared in comparative example 3 were diluted 10 times, heated and dissolved at 40 ℃, then left to stand and cool, detected by a pH meter, a composite electrode was inserted into a solution to be measured, and the pH value was measured. The pH value is measured for a plurality of times, the average value is taken, and the market demand pH value of the skin care product is 4.0 to 6.0. The test structures are shown in table 11.
TABLE 11 determination of pH values of the lotions, emulsions and creams prepared in examples 1 to 3 and comparative examples 1 to 3
The pH values of the toner, the emulsion and the face cream measured by the pH meter are all between 4.05 and 5.2, which accords with the application range of the face. The pH value of the water cream added with the natural plant extract is smaller than that of the water cream of the blank control, which shows that the plant extract is acidic, the pH value of the water cream can be influenced after the plant extract is added into the water cream, and the acidity can be increased after the plant extract is added into the skin care product.
Test example 3
Viscosity measurement of emulsions and creams prepared in examples 2 and 3
The viscosity was measured using a viscometer, and the viscometer was kept in a horizontal state. The rotor suitable for detecting emulsion and face cream is selected, and the rotor No. 07 can enter a container of the emulsion and face cream, so that the rotor No. 07 is selected, when the rotor is connected, a spindle on a main machine is held by a left hand, and the rotor is rotated by a right hand, so that the spindle and hairspring in the main machine body are prevented from being twisted off. The rotor was kept clean and dry while the samples were measured. With the viscometer, the rotor cannot touch the wall and bottom of the cup and the sample being measured runs over the prescribed scale. And (5) measuring for multiple times, and taking the value when the value is stable. The measurement results are as follows: the emulsion prepared in example 2 had a viscosity of 880 mpa.s, the cream prepared in example 3 had a viscosity of 3920 mpa.s,
Test example 4
Antioxidant testing of the lotions, emulsions and creams prepared in examples 1 to 3 and comparative examples 1 to 3
The DPPH free radical scavenging rate is used for representing the oxidation resistance of the skin care product.
DPPH can exist stably in an organic solvent, is a stable free radical, and an alcohol solution of the DPPH is purple, needs to be stored in a dark place at a low temperature and has single electron, so that the DPPH can accept one electron or hydrogen ion and has maximum absorption at a wavelength of 517 nm. In the presence of the radical scavenger, single electrons of DPPH were trapped to lighten the color, the absorbance at the maximum light absorption wavelength was decreased in a linear relationship, and the decrease in absorbance level indicated an increase in oxidation resistance, thereby evaluating the oxidation resistance of the test sample. The antioxidant capacity is expressed by the clearance rate, and the greater the clearance rate, the greater the antioxidant capacity.
Preparing a solution:
DPPH solution: 40.6mg of DPPH was dissolved in 95% ethanol and the volume was adjusted to 500mL to prepare a DPPH solution of 0.0002 mol/L.
Sample measurement:
the sample is diluted N times by 60% ethanol solution, 2.0mL of the diluted N times ethanol extract is mixed with DPPH solution, the absorbance A sample is measured at 517nm after the mixture is kept stand for 40min in dark, and the absorbance A control after the mixture of 2.0mL of DPPH solution and 2.0mL of 60% ethanol solution and the absorbance A blank after the mixture of 2.0mL of the extract and 2.0mL of 95% ethanol solution are measured by the same method. The overall blank is 95% ethanol.
Data processing
The clearance of DPPH radicals was calculated as clearance E (%) = [1- (a sample-a blank)/a control) ×100%.
The radical scavenging rate measurement data of the toner prepared in example 1, the toner prepared in comparative example 1, the emulsion prepared in example 2, the emulsion prepared in comparative example 2, the cream prepared in example 3, and the cream prepared in comparative example 3 are shown in table 12.
TABLE 12 DPPH radical scavenging Rate
Compared with the skin care products prepared in comparative examples 1-3, the DPPH free radical scavenging rate of the toner, the emulsion and the cream prepared in examples 1-3 added with the natural plant extracts is far higher than that of the skin care products prepared in comparative examples 1-3, the antioxidation capability of the skin care products is greatly improved, the antioxidant components in the plant extracts are proved to be much more, and the antioxidation effect of the toner, the emulsion and the cream added with the natural plant extracts is good, so that the efficacy of the skin care products can be greatly improved by adding the plant extracts into the skin care products. The natural plant extract can be well fused with various substances of the basic skin care product and keep relatively high activity, so that excessive free radicals on the skin surface are removed to a certain extent, and excessive oxidation of the skin is prevented, and the skin darkness caused by oxidation is solved.
The skin care products prepared in comparative examples 1 to 3 also have antioxidant ability because of the allantoin added during the preparation process, and the research table shows that the salt tolerance of betaine can be efficiently enhanced due to the antioxidant activity of allantoin.
Test example 5
Tyrosinase activity resistance test of the toners, emulsions and creams prepared in examples 1 to 3 and comparative examples 1 to 3
Tyrosinase activity refers to the activity intensity or liveness of tyrosinase. Tyrosinase is an oxidoreductase which plays a critical role in melanin synthesis and can convert tyrosine in the human body to dopaquinone and evolve to melanin. The activity of tyrosinase is directly proportional to the amount of melanin produced, and the activity of tyrosinase also determines the rate and yield of melanin production.
Tyrosinase inhibitory activity was measured using the modified dopachrome method with L-DOPA as substrate.
The sample solution (25. Mu.L) was mixed with tyrosinase solution (40. Mu.L; 127U/mL) and phosphate buffer (100. Mu.L, pH 6.8) in 96-well microwell plates and incubated at 25℃for 15 min. L-DOPA (40. Mu.L; 2.5 mM) was then added to initiate the reaction. Similarly, a blank was prepared by adding the sample solution to all reagents without enzyme (tyrosinase) solution. After incubation for 10 minutes at 25 ℃, the sample and blank absorbance were read at 492 nm. The absorbance of the blank was subtracted from the absorbance of the sample. The results are reported as percent inhibition and calculated according to the equation shown in fig. 1. The test results are shown in Table 13.
TABLE 13 anti-tyrosinase activity
The tyrosinase-resisting activities of the skin-refreshing water, the emulsion and the cream prepared in the comparative examples 1-3 without adding the natural plant extract are all negative numbers, which shows that the skin-care product without adding any extract component has no whitening effect.
As can be seen from Table 13, the addition of the extracts of examples 1 to 3 also inhibited tyrosinase activity, reduced melanin production from the root, and whitened our skin. Therefore, the peony extract for oil is expected to be used as an effective component for preparing skin care products with whitening and antioxidation effects.
Functional components in the natural plant extract can inhibit synthesis of melanin and tyrosinase, and the whitening components in the natural plant extract are extracted by adopting a corresponding experimental method and are applied to skin care products, so that the natural, high-safety and easy-to-absorb whitening antibacterial effect is reflected. Because of the potential mutation and skin irritation of skin care products, finding natural plants as whitening agents is a development trend in the skin care product industry. The natural plants have high safety and certain physiological activity, and meet the demands of consumers. The natural plant is rich in a certain whitening active ingredient, the skin is less damaged even no damage is caused to the skin in the application process, and the whitening effect is ideal, so that the research of the whitening active ingredient of the natural plant is gradually emphasized in the research process of the whitening product, the whitening degree of the skin of a user is improved by adding the corresponding whitening active ingredient into the skin care product, and the damage to the skin can be reduced to the greatest extent by adopting the mode. Therefore, research on natural whitening active ingredients is increasingly receiving attention.
The optimal formula is obtained through multiple formula adjustment, the whitening water cream is prepared, the pH value, viscosity, DPPH free radical clearance and tyrosinase inhibition of the water cream are tested for detecting the efficacy of the water cream, the pH values of the water cream are respectively 4.06, 4.16 and 4.18, and the viscosities of the emulsion and the face cream are 880 mpa.s and 3920 mpa.s, which all meet the national standard. DPPH clearance rates of the water cream are 53.82%, 61.38% and 49.73%, and anti-tyrosinase activities are 14.54%, 13.73% and 24.28%, indicating that the water cream has suitable properties in all aspects.
Although the foregoing embodiments have been described in some, but not all embodiments of the invention, other embodiments may be obtained according to the present embodiments without departing from the scope of the invention.
Claims (7)
1. The compound natural plant extract is characterized by comprising the following components in parts by weight: 0.5 part of raspberry extract, 0.5 part of jasmine extract, 0.5 part of mint extract, 0.5 part of portulaca oleracea extract, 0.5 part of chamomile extract, 0.5 part of aloe kura extract, 2 parts of raspberry fruit residue extract, 0.005 part of peony leaf extract, 0.005 part of peony root extract, 0.005 part of raspberry leaf extract, 0.005 part of raspberry young fruit extract and 0.005 part of coconut coir extract;
The preparation method of the coconut shell extract comprises the following steps: taking 60% acetone as an extraction solvent, carrying out extraction at a feed liquid ratio of 1:5, an ultrasonic temperature of 80 ℃ for 80min and a power of 225W, homogenizing for 5min at 10000r/min, taking a supernatant stock solution as a sample loading liquid after rotary evaporation to remove alcohol, loading samples at a speed of 5BV/h by using an AB-8 macroporous resin column, wherein the height-diameter ratio of the AB-8 macroporous resin column is 15:3, eluting with 60% ethanol at the eluting speed of 0.5BV/h, eluting with distilled water with impurity content of 2BV and eluting with eluent with content of 4BV, collecting eluent, concentrating, and drying to obtain coconut husk extract.
2. A whitening toner, which is characterized by comprising a toner base component and a natural plant extract active component, wherein the natural plant extract active component is the compound natural plant extract of claim 1; the mass ratio of the base component of the toner to the active component of the natural plant extract is (94.9-99) (1-5.1); the toner base component comprises glycerin, sodium hyaluronate, water and ethanol.
3. The whitening toner according to claim 2, wherein the whitening toner comprises the following components in parts by mass: 3.5 to 4.5 parts of glycerin, 0.05 to 0.15 part of sodium hyaluronate, 1 to 5.1 parts of natural plant extract active components, 89 to 93.5 parts of water and 0.5 to 1.5 parts of ethanol.
4. A whitening emulsion, which is characterized by comprising an emulsion base component and a natural plant extract active component, wherein the natural plant extract active component is the compound natural plant extract of claim 1; the mass ratio of the emulsion basic component to the natural plant extract active component is (94.9-99): 1-5.1; the emulsion base component comprises caprylic capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, simethicone, cyclopentadimethicone, liquid paraffin, squalane, glycerol, propylene glycol, carbomer, allantoin and water.
5. The whitening emulsion according to claim 4, which comprises the following components in parts by mass: 3 to 4.5 parts of caprylic/capric triglyceride, 1 to 2 parts of cetostearyl alcohol, 1 to 2 parts of cetostearyl glucoside, 1 to 2.5 parts of simethicone, 0.5 to 1.5 parts of cyclopentadimethicone, 1 to 2.5 parts of liquid paraffin, 2 to 4.5 parts of squalane, 1 to 3.5 parts of glycerol, 4 to 6 parts of propylene glycol, 0.1 to 3 parts of carbomer, 0.1 to 0.5 part of allantoin, 1 to 5.1 parts of natural plant extract active components and 72 to 77.5 parts of water.
6. A whitening cream, which is characterized by comprising a basic component of the cream and an active component of a natural plant extract, wherein the active component of the natural plant extract is the compound natural plant extract of claim 1; the mass ratio of the basic component of the face cream to the active component of the natural plant extract is (94.9-99): 1-5.1; the base component of the cream comprises caprylic capric triglyceride, cetostearyl alcohol, cetostearyl glucoside, simethicone, cyclopentadimethicone, liquid paraffin, squalane, vaseline, shea butter, glycerol, propylene glycol, carbomer, allantoin and water.
7. The whitening cream according to claim 6, which comprises the following components in parts by mass: 5 to 7 parts of caprylic/capric triglyceride, 1 to 2 parts of cetostearyl alcohol, 2 to 4 parts of cetostearyl glucoside, 3 to 5 parts of simethicone, 0.5 to 2 parts of cyclopentamethylsilicone, 3 to 10 parts of liquid paraffin, 5 to 8 parts of squalane, 3 to 5 parts of Vaseline, 1 to 3 parts of shea butter, 3.75 to 5 parts of glycerol, 4 to 8 parts of propylene glycol, 0.4 to 6 parts of carbomer, 0.3 to 0.8 part of allantoin, 1 to 5.1 parts of natural plant extract active components and 31 to 67.5 parts of water.
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