CN114569517A - Antioxidant whitening cream - Google Patents
Antioxidant whitening cream Download PDFInfo
- Publication number
- CN114569517A CN114569517A CN202210376052.3A CN202210376052A CN114569517A CN 114569517 A CN114569517 A CN 114569517A CN 202210376052 A CN202210376052 A CN 202210376052A CN 114569517 A CN114569517 A CN 114569517A
- Authority
- CN
- China
- Prior art keywords
- cream
- flower bud
- sophora flower
- bud extract
- glucosidase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006071 cream Substances 0.000 title claims abstract description 40
- 230000002087 whitening effect Effects 0.000 title claims abstract description 22
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 12
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 8
- 241000219784 Sophora Species 0.000 claims abstract description 48
- 239000002537 cosmetic Substances 0.000 claims abstract description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 22
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 18
- 108090000145 Bacillolysin Proteins 0.000 claims description 13
- 102000035092 Neutral proteases Human genes 0.000 claims description 13
- 108091005507 Neutral proteases Proteins 0.000 claims description 13
- 102000006995 beta-Glucosidase Human genes 0.000 claims description 13
- 108010047754 beta-Glucosidase Proteins 0.000 claims description 13
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 10
- 229920006007 hydrogenated polyisobutylene Polymers 0.000 claims description 10
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 10
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 10
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 9
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 9
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 9
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 9
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 9
- 229920002125 Sokalan® Polymers 0.000 claims description 9
- 229960003237 betaine Drugs 0.000 claims description 9
- 229960001631 carbomer Drugs 0.000 claims description 9
- 150000004676 glycans Chemical class 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 9
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 9
- 229940101267 panthenol Drugs 0.000 claims description 9
- 235000020957 pantothenol Nutrition 0.000 claims description 9
- 239000011619 pantothenol Substances 0.000 claims description 9
- 229920001282 polysaccharide Polymers 0.000 claims description 9
- 239000005017 polysaccharide Substances 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 9
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 9
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 9
- 229940032094 squalane Drugs 0.000 claims description 9
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- -1 caprylyl hydroxamic Chemical compound 0.000 claims description 7
- 230000007071 enzymatic hydrolysis Effects 0.000 claims description 6
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims description 6
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims description 6
- 108010059820 Polygalacturonase Proteins 0.000 claims description 4
- 230000003064 anti-oxidating effect Effects 0.000 claims description 4
- 108010093305 exopolygalacturonase Proteins 0.000 claims description 4
- 244000046101 Sophora japonica Species 0.000 claims description 3
- 235000010586 Sophora japonica Nutrition 0.000 claims description 3
- 229960005150 glycerol Drugs 0.000 claims description 3
- 229960004063 propylene glycol Drugs 0.000 claims description 3
- 230000002255 enzymatic effect Effects 0.000 claims description 2
- 239000002304 perfume Substances 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 7
- 238000011056 performance test Methods 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 description 17
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 14
- 238000000034 method Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 238000000605 extraction Methods 0.000 description 6
- 241000411851 herbal medicine Species 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- OCZVHBZNPVABKX-UHFFFAOYSA-N 1,1-diphenyl-2-(2,4,6-trinitrophenyl)hydrazine;ethanol Chemical compound CCO.[O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1NN(C=1C=CC=CC=1)C1=CC=CC=C1 OCZVHBZNPVABKX-UHFFFAOYSA-N 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 102000003425 Tyrosinase Human genes 0.000 description 2
- 108060008724 Tyrosinase Proteins 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000036564 melanin content Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- JYDNKGUBLIKNAM-UHFFFAOYSA-N Oxyallobutulin Natural products C1CC(=O)C(C)(C)C2CCC3(C)C4(C)CCC5(CO)CCC(C(=C)C)C5C4CCC3C21C JYDNKGUBLIKNAM-UHFFFAOYSA-N 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- FVWJYYTZTCVBKE-ROUWMTJPSA-N betulin Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C FVWJYYTZTCVBKE-ROUWMTJPSA-N 0.000 description 1
- MVIRREHRVZLANQ-UHFFFAOYSA-N betulin Natural products CC(=O)OC1CCC2(C)C(CCC3(C)C2CC=C4C5C(CCC5(CO)CCC34C)C(=C)C)C1(C)C MVIRREHRVZLANQ-UHFFFAOYSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 description 1
- IUCHKMAZAWJNBJ-RCYXVVTDSA-N oleanolic acid 3-O-beta-D-glucosiduronic acid Chemical compound O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2C1(C)C)C)(C)CC[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O IUCHKMAZAWJNBJ-RCYXVVTDSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention belongs to the field of cosmetics, and particularly relates to an antioxidant whitening cream containing a sophora flower bud extract, wherein the sophora flower bud extract is subjected to enzymolysis treatment. In addition, the performance test of the cream prepared by adopting the sophora flower bud extract enzymolysis product shows that the antioxidant activity of the product is greatly improved, and the whitening effect is obvious.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to an antioxidant whitening cream containing sophora flower bud extract.
Background
Skin whitening has been the subject of active research in dermatology and related sciences. In order to whiten the skin, it is necessary to suppress the excessive production of melanin in the skin. There are three essential substances necessary for the formation of melanin: tyrosine, tyrosinase, and oxygen. Modern cosmetics achieve the effect of whitening the skin of consumers mainly by inhibiting tyrosinase activity, resisting oxidation and eliminating oxygen radicals.
In recent decades, due to the progress of science and technology and the approval of people, the antioxidant properties of flavonoids, polyphenols and their derivatives in Chinese herbal medicines have been paid much attention. The scholars systematically screen and evaluate a plurality of Chinese herbal medicines, and find that more than half of the Chinese herbal medicines have the antioxidation effect. In many cosmetics, a large amount of unsaturated fatty acid exists in oil phase and water phase oil phase, and the oil phase and the water phase oil phase are extremely easy to be oxidized and rancid in the processes of processing, transportation and storage, so that not only are the sensory properties influenced, but also the functionality is reduced, and even toxic and harmful substances are generated. Various Chinese herbal medicines have strong oxidation resistance to oleic acid, so that the shelf life of cosmetics can be prolonged. Researchers at home and abroad begin to turn the attention to the field of natural Chinese herbal medicines, and more natural Chinese herbal medicine antioxidants are expected to be developed.
The sophora flower bud is one of plants with the highest content of flavonoid compounds, contains flavonoid compounds such as rutin, betulin, sophoricediol, sophora flower bud element A and peruvian, sophora flower saponin I, II and III, a small amount of fatty acid and the like, and has remarkable oxidation resistance and free radical resistance. In the prior art, ethanol-water solution is used as an extraction solvent for the active ingredients of the sophora flower bud, but the extraction efficiency is low, the process is time-consuming and energy-consuming, and on the contrary, the biological enzyme method for extracting the active ingredients of the traditional Chinese medicine has the characteristics of high extraction efficiency and difficulty in causing waste and pollution of effective resources, thereby becoming a research hotspot of the existing extraction method. In recent years, researchers at home and abroad continuously research the active ingredients of the sophora japonica and apply the active ingredients to products such as medicines, foods, industrial dyes and the like, but related documents on the research of the application of the sophora japonica to cosmetics do not exist at present.
Disclosure of Invention
In order to make up the blank and the defect of the existing research and improve the antioxidation whitening function of cosmetics, the invention provides the antioxidation whitening cream containing the sophora flower bud extract. In the development and experiment process, the sophora flower bud extract obtained by treating the sophora flower bud with beta-glucosidase, neutral protease and pectinase has higher moisturizing capability compared with the sophora flower bud extract which is not treated by enzyme. And in the performance test of the face cream prepared by adopting the sophora flower bud extract enzymolysis product, the antioxidant activity of the product is greatly improved, and the whitening effect is obvious.
In order to achieve the above object, the present invention adopts the following technical solutions:
an antioxidant whitening cream comprises raw material components of sophora flower bud extract.
Preferably, the raw material components of the face cream further comprise water, glycerin, propylene glycol, betaine, carbomer, EDTA-disodium, hydrogenated polyisobutene, caprylic/capric triglyceride, glyceryl monostearate, sodium hyaluronate, panthenol, squalane, algal polysaccharides, caprylhydroxamic acid and essence.
Preferably, the face cream consists of the following raw material components in percentage by weight: 8-15% of sophora flower bud extract, 1-6% of glycerol, 1-4% of propylene glycol, 1-2% of betaine, 0.5-2% of carbomer, 0.1-0.3% of EDTA-disodium, 1-4% of hydrogenated polyisobutene, 1-4% of caprylic/capric triglyceride, 2-8% of glyceryl monostearate, 4-8% of sodium hyaluronate, 0.2-0.5% of panthenol, 1-3% of squalane, 2-4% of algal polysaccharide, 0.1-0.3% of caprylyl hydroximic acid, 0.1-0.3% of essence and the balance of water.
Preferably, the face cream consists of the following raw material components in percentage by weight: sophora flower bud extract 13%, glycerin 6%, propylene glycol 3%, betaine 1%, carbomer 1.5%, EDTA-disodium 0.2%, hydrogenated polyisobutene 3%, caprylic/capric triglyceride 3%, glyceryl monostearate 5%, sodium hyaluronate 6%, panthenol 0.3%, squalane 3%, algal polysaccharide 4%, caprylyl hydroximic acid 0.1%, essence 0.1%, and the balance of water.
Preferably, the sophora flower bud extract is subjected to enzymolysis treatment.
Preferably, the enzyme used for enzymolysis is one or more of beta-glucosidase, neutral protease and pectinase.
Preferably, the enzyme used for the enzymatic hydrolysis is beta-glucosidase and neutral protease.
Preferably, the enzymolysis conditions are as follows: beta-glucosidase 200U/g sophora flower bud extract and neutral protease 100U/g sophora flower bud extract are used, the enzymolysis time is 1h, and the enzymolysis temperature is 45 ℃.
Further, the invention provides application of the sophora flower bud extract subjected to enzymolysis treatment in an antioxidant whitening cosmetic.
Preferably, the enzyme used for the enzymatic hydrolysis is beta-glucosidase and neutral protease.
The invention has the beneficial effects that: the sophora flower bud extract is innovatively used in the cosmetics, the application blank of sophora flower buds in the field of cosmetics is filled, and meanwhile, the novel face cream with strong whitening effect is provided. The method further processes the sophora flower bud extract by adopting an enzymolysis method, so that the effective active ingredients in the sophora flower buds are more effectively extracted, the extraction rate is higher compared with the conventional chemical extraction method, and the obtained sophora flower bud extract has stronger oxidation resistance. Compared with the whitening cream on the market, the sophora flower bud extract subjected to enzymolysis treatment by using beta-glucosidase and neutral protease is used as the main raw material component, and the finished product of the cream obtained by the formula and the method not only meets the physical and chemical index requirements of cosmetics, but also has good effects on skin moisture retention, melanin inhibition and skin brightness increase.
Detailed Description
The technical solutions in the embodiments of the present invention will be examined and completely described below with reference to the embodiments of the present invention, so as to further explain the invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. Given the embodiments of the present invention, all other embodiments that can be obtained by a person of ordinary skill in the art without any inventive step are within the scope of the present invention.
Main experimental reagents and materials:
flos Sophorae Immaturus is purchased from Shandong producing area (applicant fully crushes flos Sophorae Immaturus, sieves, adds 60% ethanol according to the material-liquid ratio of 1: 40, puts into 60 deg.C constant temperature water bath to extract for 1h, filters and dries).
Beta-glucosidase, neutral protease and pectinase were purchased from Solebao Biotech, Inc. of Beijing.
Glycerol, propylene glycol, betaine, carbomer, EDTA-disodium, hydrogenated polyisobutene, caprylic/capric triglyceride, glyceryl monostearate, sodium hyaluronate, panthenol, squalane, algal polysaccharides, caprylyl hydroxamic acid and perfume were all purchased from commercially available products.
Example 1 enzymatic treatment of Sophora flower bud extract and product
Example 2 testing of moisturizing ability of Sophora flower bud extract
The experimental conditions are as follows: the test environment temperature is 20 ℃, the relative humidity is 45-55%, the same indoor light condition is kept, and real-time dynamic monitoring is carried out.
Preparation before testing: four groups of volunteers, aged 20-45 years, were selected and tested for skin non-traumatic. The test site cannot use any cosmetics or external drugs 2-3 days before the test. Before the test, a tested part needs to be cleaned by a tested subject, a plurality of areas can be marked simultaneously after the cleaning, the interval between every two testing areas is at least 1cm, basic data is tested after the tested subject sits statically for 30min in a constant-temperature and constant-humidity environment, water and beverage cannot be drunk in the period, the tested subject is placed in a testing state, and a relaxation state is kept.
The method comprises the following steps:
refer to QB/T4256-.
Firstly, a test sample is coated for one time according to a certain dosage, a latex finger sleeve is used for uniformly coating the sample in a test area, and the actual sample coating quantity is recorded.
Measuring the tested part with the skin analyzing and testing instrument for at least 3 times. The initial value of each test area (before sample application) was measured and then the skin moisture content of the test area was measured after a set time.
Measuring the skin water content of the tested area 30min, 1h and 2h after smearing respectively. The test of the same subject must be done by the same measuring person using the same instrument, and the measuring probe should be cleaned between the two measurements.
The results of the experiment are shown in table 1:
TABLE 1 Effect of Sophora flower bud extract on skin moisture content
The experimental results show that the water content of the skin can be improved by using the sophora flower bud extract, the moisture-retaining capacity of the sophora flower bud extract is greatly improved after further enzymolysis treatment, wherein the effect of carrying out composite enzymolysis on the sophora flower bud extract by using beta-glucosidase and neutral protease is better, and the time for maintaining the water content of the skin is longer.
EXAMPLE 3 preparation of cream
The raw material formula of the face cream is as follows: sophora flower bud extract 13%, glycerin 6%, propylene glycol 3%, betaine 1%, carbomer 1.5%, EDTA-disodium 0.2%, hydrogenated polyisobutene 3%, caprylic/capric triglyceride 3%, glyceryl monostearate 5%, sodium hyaluronate 6%, panthenol 0.3%, squalane 3%, algal polysaccharide 4%, caprylyl hydroximic acid 0.1%, essence 0.1%, and the balance of water.
The preparation process comprises the following steps: according to the formula content, placing hydrogenated polyisobutene, caprylic/capric triglyceride and glyceryl monostearate in a water bath kettle at the temperature of 75-80 ℃ and slowly stirring for about 30 min-1 h until all the hydrogenated polyisobutene, caprylic/capric triglyceride and glyceryl monostearate are dissolved to obtain a mixture A; then dispersing carbomer in water uniformly in advance, adding water, glycerol, propylene glycol, betaine, EDTA-disodium, algal polysaccharide, sodium hyaluronate, squalane, panthenol and caprylyl hydroximic acid, and then placing the mixture in a water bath kettle at 75-80 ℃ to stir at a constant speed for about 30 min-1 h until the mixture is completely dissolved to obtain a mixture B; and mixing the mixture A and the mixture B, adding the sophora flower bud extract, the rest water and the essence, continuously stirring uniformly, cooling to 30-35 ℃, stopping stirring, discharging, and preparing to obtain a cream sample.
Example 4 testing of antioxidant Activity and whitening Capacity of cream
The cream samples were prepared according to the cream preparation method described in example 3, in which the contents of the components were the same except that the treatment pattern of the sophora flower bud extract was not uniform. In the embodiment, the performance test comparison is carried out on the face cream prepared by the sophora flower bud extract enzymolysis product 3 and the sophora flower bud extract which is not subjected to enzymolysis.
Determination of DPPH organic radical scavenging Capacity: taking 2g of different face cream samples, adding 4.0mL of 2x10-4Uniformly mixing mol/L DPPH ethanol solution, standing for 30min, taking a solvent as a control sample, and recording the absorbance at the wavelength of 517nm as A1; a2 is the mixture of 2g sample and 4.0mL ethanol water solutionAbsorbance at wavelength 517 nm; and then 4.0mL of DPPH ethanol solution is mixed with 4.0mL of ethanol solution, the absorbance measured at the wavelength of 517nm is recorded as A3, and the clearance rate% of K organic free radicals is calculated as follows:
the experimental result shows that the DPPH free radical clearance of the cream containing the sophora flower bud extract enzymolysis product 3 is 79.02%, the DPPH free radical clearance of the cream containing the sophora flower bud extract which is not subjected to enzymolysis is 55.28%, and the sophora flower bud extract which is subjected to composite enzymolysis treatment by beta-glucosidase and neutral protease has good antioxidant activity.
The whitening ability evaluation method comprises the following steps: the skin whitening effect of the product can be reflected by measuring the reduction amount of the skin melanin. Since the short-term effect of the melanin content is not significant, the whitening effect of the product on the skin is analyzed and evaluated from the long-term effect. The test conditions were consistent with the moisturizing ability of example 2.
The test results are shown in table 3:
TABLE 3 skin melanin reduction
The experimental results show that the face cream 1 and the face cream 2 both have the effect of inhibiting melanin, which indicates that the sophora flower bud extract can be used as a whitening component in skin care products, wherein the face cream 1 containing the sophora flower bud extract enzymolysis product 3 has excellent melanin inhibition capability, and the skin melanin content can be obviously reduced and the whitening effect is obvious by using the face cream 1 of the invention along with the time.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention, including any reference to the above-mentioned embodiments. Various modifications to these embodiments will be readily apparent to those skilled in the art. The general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. The anti-oxidation whitening cream is characterized in that raw material components of the cream comprise sophora flower bud extract.
2. The cream of claim 1, wherein the raw ingredients of the cream further comprise water, glycerin, propylene glycol, betaine, carbomer, disodium EDTA, hydrogenated polyisobutene, caprylic/capric triglyceride, glyceryl monostearate, sodium hyaluronate, panthenol, squalane, algal polysaccharide, caprylyl hydroxamic acid, and perfume.
3. The cream according to claim 2, wherein the cream consists of the following raw material components in content: 8-15% of sophora flower bud extract, 1-6% of glycerol, 1-4% of propylene glycol, 1-2% of betaine, 0.5-2% of carbomer, 0.1-0.3% of EDTA-disodium, 1-4% of hydrogenated polyisobutene, 1-4% of caprylic/capric triglyceride, 2-8% of glyceryl monostearate, 4-8% of sodium hyaluronate, 0.2-0.5% of panthenol, 1-3% of squalane, 2-4% of algal polysaccharide, 0.1-0.3% of caprylyl hydroximic acid, 0.1-0.3% of essence and the balance of water.
4. The cream according to claim 3, wherein the cream consists of the following raw material components in content: sophora flower bud extract 13%, glycerin 6%, propylene glycol 3%, betaine 1%, carbomer 1.5%, EDTA-disodium 0.2%, hydrogenated polyisobutene 3%, caprylic/capric triglyceride 3%, glyceryl monostearate 5%, sodium hyaluronate 6%, panthenol 0.3%, squalane 3%, algal polysaccharide 4%, caprylyl hydroximic acid 0.1%, essence 0.1%, and the balance of water.
5. The cream according to any one of claims 1 to 4, wherein the extract of Sophora japonica is treated by enzymatic hydrolysis.
6. The cream according to claim 5, wherein the enzyme used for enzymatic hydrolysis is one or more of β -glucosidase, neutral protease and pectinase.
7. The cream according to claim 6, wherein the enzymes used for enzymatic hydrolysis are β -glucosidase and neutral protease.
8. The cream of claim 7, wherein the enzymatic conditions are: beta-glucosidase 200U/g sophora flower bud extract and neutral protease 100U/g sophora flower bud extract are used, the enzymolysis time is 1h, and the enzymolysis temperature is 45 ℃.
9. Use of the enzymatically treated sophora flower bud extract of any one of claims 5-8 in an antioxidant whitening cosmetic.
10. The use according to claim 9, wherein the enzymes used for enzymatic hydrolysis are β -glucosidase and neutral protease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210376052.3A CN114569517B (en) | 2022-04-11 | 2022-04-11 | Antioxidant whitening cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210376052.3A CN114569517B (en) | 2022-04-11 | 2022-04-11 | Antioxidant whitening cream |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114569517A true CN114569517A (en) | 2022-06-03 |
| CN114569517B CN114569517B (en) | 2024-03-15 |
Family
ID=81778015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210376052.3A Active CN114569517B (en) | 2022-04-11 | 2022-04-11 | Antioxidant whitening cream |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114569517B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115192490A (en) * | 2022-07-20 | 2022-10-18 | 广州睿森生物科技有限公司 | Nano microemulsion NMN composition and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130023606A (en) * | 2011-08-29 | 2013-03-08 | 동국대학교 경주캠퍼스 산학협력단 | Composition for whitening of the skin comprising an extract of sophora japonica l., leguminosae |
| CN104151380A (en) * | 2014-06-22 | 2014-11-19 | 北京安德益源生物科技有限公司 | Preparation method of high-purity rutin |
| KR20150052907A (en) * | 2013-11-06 | 2015-05-15 | 주식회사 코리아나화장품 | Cosmetic composition for Improving Skin Moisturization Comprising the mixed extract of Peach blossom, Sophora japonica flower, Rhubarb and Clove buds as active ingredient |
| CN106473987A (en) * | 2016-11-29 | 2017-03-08 | 广州睿森生物科技有限公司 | The anti-ageing compositionss of whitening and cosmetics |
| CN112263525A (en) * | 2020-09-18 | 2021-01-26 | 广州瀚海科技有限公司 | Natural cosmetic with whitening effect |
| CN114053183A (en) * | 2021-10-18 | 2022-02-18 | 深圳市兰亭科技股份有限公司 | Composition with multi-target scalp itching relieving effect |
-
2022
- 2022-04-11 CN CN202210376052.3A patent/CN114569517B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130023606A (en) * | 2011-08-29 | 2013-03-08 | 동국대학교 경주캠퍼스 산학협력단 | Composition for whitening of the skin comprising an extract of sophora japonica l., leguminosae |
| KR20150052907A (en) * | 2013-11-06 | 2015-05-15 | 주식회사 코리아나화장품 | Cosmetic composition for Improving Skin Moisturization Comprising the mixed extract of Peach blossom, Sophora japonica flower, Rhubarb and Clove buds as active ingredient |
| CN104151380A (en) * | 2014-06-22 | 2014-11-19 | 北京安德益源生物科技有限公司 | Preparation method of high-purity rutin |
| CN106473987A (en) * | 2016-11-29 | 2017-03-08 | 广州睿森生物科技有限公司 | The anti-ageing compositionss of whitening and cosmetics |
| CN112263525A (en) * | 2020-09-18 | 2021-01-26 | 广州瀚海科技有限公司 | Natural cosmetic with whitening effect |
| CN114053183A (en) * | 2021-10-18 | 2022-02-18 | 深圳市兰亭科技股份有限公司 | Composition with multi-target scalp itching relieving effect |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115192490A (en) * | 2022-07-20 | 2022-10-18 | 广州睿森生物科技有限公司 | Nano microemulsion NMN composition and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114569517B (en) | 2024-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2015135313A1 (en) | Borojo skin care product and use thereof for natural moisturizing, anti-ageing, anti-uv, anti-anaphylaxis and whitening | |
| CN111481481B (en) | Spun gold royal chrysanthemum nanotechnology skin care product and preparation method and application thereof | |
| CN113081910B (en) | Repairing composition and application thereof | |
| CN106580778A (en) | Macadamia nut green peel extract, cosmetics employing same as active ingredient and preparation method of macadamia nut green peel extract | |
| CN108815080B (en) | Preparation method of plant extract with black eye removing effect | |
| CN109453087B (en) | Whitening skin-penetrating lotion, preparation method thereof and whitening cosmetic additive | |
| CN105381007A (en) | Externally-applied traditional Chinese medicine composition with effect on whitening skin, preparation as well as preparation method and application thereof | |
| CN111407678A (en) | Microemulsion with moisturizing, skin-brightening and anti-aging effects and preparation method thereof | |
| CN110613641A (en) | Zero-corrosion-resistance composition and application thereof in cosmetics | |
| CN113208960A (en) | Skin care composition for controlling oil and repairing skin barrier and preparation method and application thereof | |
| CN111514072B (en) | Millettia speciosa-noni composite enzyme, preparation method thereof and application of millettia speciosa-noni composite enzyme in preparation of facial mask | |
| CN112156062A (en) | Composition with anti-inflammatory and repairing activity and essence containing composition | |
| CN115554226A (en) | Multi-strain fermentation filtrate and preparation method and application thereof | |
| CN114569517B (en) | Antioxidant whitening cream | |
| CN114010553B (en) | Composition for controlling oil and refining pores and preparation and application thereof | |
| CN114259445B (en) | Composition with anti-wrinkle and antioxidation effects and microcapsule preparation method thereof | |
| CN110101586B (en) | Nourishing, tightening and whitening mask paste and preparation method thereof | |
| CN113143820A (en) | Anti-aging composition and preparation method thereof | |
| TW202106323A (en) | Use ofrosmarinus officinaliscallus extract for manufacturing composition inhibiting skin aging and a culture medium for inducingrosmarinus officinaliscallus | |
| CN111297733A (en) | Paeonol-containing high-moisture-retention sun-screening agent and preparation method thereof | |
| CN110897961A (en) | Birchleaf pear flower compound antioxidant beautifying toner and preparation method thereof | |
| CN113730291B (en) | Torreya grandis compound oil, preparation method and application | |
| CN106562913B (en) | External composition with whitening effect, cosmetic preparation and preparation method thereof | |
| Amornlerdpison et al. | Antioxidant activity of Padina minor Yamada | |
| KR100955388B1 (en) | Cosmetic composition for anti-inflammation and anti-aging and preparing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20220708 Address after: No. 9 Yinyin harbor, Binjiang District, Hangzhou, Zhejiang 310053 Applicant after: Zheng Jinfang Address before: No. 9 Yinyin harbor, Binjiang District, Hangzhou, Zhejiang 310053 Applicant before: Hangzhou Fuli Network Information Technology Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20240218 Address after: 510000 Room 501, building A3, No. 81, Yongtai xueshantang street, Yongping street, Baiyun District, Guangzhou, Guangdong Province Applicant after: Guangzhou birou Biotechnology Co.,Ltd. Country or region after: China Address before: No. 9 Yinyin harbor, Binjiang District, Hangzhou, Zhejiang 310053 Applicant before: Zheng Jinfang Country or region before: China |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |