CN114867738A - 肿瘤靶向蛋白或其片段、与其结合的抗体及其用途 - Google Patents
肿瘤靶向蛋白或其片段、与其结合的抗体及其用途 Download PDFInfo
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Abstract
本发明涉及一种肿瘤靶向蛋白或其片段、与其结合的抗体及其用途。更具体地，本发明涉及包含编码蛋白A56或其片段的核酸的载体及其用途。此外，本发明涉及结合蛋白A56或其片段的抗体及其用途。本发明使用溶瘤病毒作为载体，所述载体含有编码本发明的蛋白A56、或其片段或其突变体的核酸，因此当施用于个体时，主要特异性地仅杀死癌细胞。此外，即使在被溶瘤病毒感染后仍存活的癌细胞，其在细胞表面上表达蛋白A56，这使得其能够被靶向以进行二次抗癌治疗。因此，根据本发明的一个实施方案，当使用含有编码蛋白A56或其片段的核酸的载体，以及结合A56的抗体时，可以有效地治疗癌症。
Description
技术领域
本发明涉及肿瘤靶向蛋白或其片段、与其结合的抗体及其用途。更具体地，本发明涉及包含编码蛋白A56片段的核酸的载体及其用途。另外，本发明涉及与蛋白A56或其片段特异性结合的抗体及其用途。
背景技术
癌症也称为肿瘤，是指由于身体组织自主过度生长而异常增殖的细胞。由于现代社会人口老龄化、吸烟人口增加、饮酒量增加、饮食习惯西化以及环境污染的问题，癌症发病率持续上升。
治疗癌症的方法包括手术、放疗、化疗等。具体而言，手术是一种从体内去除癌组织的治疗方法，对于早期癌症或病变局限于特定位置的癌症非常有效。然而，侵入病灶周围组织或已转移至淋巴结的癌症很难去除，并且这种癌症复发的可能性很高。在这种情况下，放疗或化疗与手术结合使用。放疗或化疗主要用于晚期或末期癌症的治疗；然而，这种疗法也会影响正常细胞，从而导致严重的副作用。
近来，免疫细胞疗法作为一种癌症治疗方法已被积极研究。免疫细胞疗法与现有治疗方法的不同之处在于它利用患者的免疫细胞杀死癌细胞。具体而言，免疫细胞疗法是从患者体内获取免疫细胞，激活后特异性攻击增殖细胞或癌细胞，然后将其返回患者体内的方法。这种方法最大限度地提高了抗癌效果，同时最大限度地减少了药物引起的副作用。
此外，在过去的5年中，免疫检查点抑制剂已被积极研究用于治疗癌症的免疫疗法。特别是已经研究了针对免疫检查点的抑制剂，例如细胞毒性T淋巴细胞相关蛋白4(CTLA-4)、程序性细胞死亡蛋白1(PD-1)和PD-L1。免疫检查点抑制剂，如伊匹单抗(ipilimumab，抗CTLA-4)、纳武单抗(nivolumab，抗PD-1)和派姆单抗(pembrolizumab，抗PD-1)，已被监管机构批准用于治疗多种类型的癌症。然而，免疫检查点抑制剂仅限于治疗某些类型的癌症，如黑色素瘤、肺癌、头颈癌、肾癌和膀胱癌。
因此，需要持续研究和开发安全、甚至能够有效靶向实体癌的癌细胞靶向方法。
发明内容
技术问题
因此，为了开发安全有效地靶向癌细胞的方法，本发明人进行了研究，发现在通过注射含有编码蛋白A56或其片段的核酸的载体处理癌细胞的情况下，蛋白A56在癌细胞表面表达。另外，本发明人发现与蛋白A56或其片段结合的抗体与表达在癌细胞表面的蛋白A56结合，从而完成了本发明。
技术问题的解决方案
在本发明的一个方面，提供了一种抗癌剂，其包含特异性结合蛋白A56或其片段的抗体或其片段作为活性成分。
在本发明的另一个方面，提供了一种溶瘤病毒，其包含编码蛋白A56或其片段的核酸。
在本发明的另一方面，提供了结合蛋白A56或其片段的抗体或其片段。
在本发明的另一方面，提供了一种靶向癌症的多肽或其片段，该多肽包括由SEQID NO:1038、1040、1042、1044、1046、1048、1050、1052、1054、1056、1058、1060、1073、1075、1077或1079所示的氨基酸序列。
在本发明的另一方面，提供了一种编码所述靶向癌症的多肽或其片段的分离的核酸。
在本发明的另一方面，提供了一种用于治疗癌症的试剂盒，包括所述溶瘤病毒和所述抗体或其片段。
在本发明的另一方面，提供了一种用于靶向癌症的药物组合物，其包含所述溶瘤病毒。
发明的有益效果
本发明的溶瘤病毒含有编码蛋白A56或其片段或变体的核酸，在作为载体被施用于个体的情况下，主要以特异性的方式仅杀死癌细胞。此外，即使感染溶瘤病毒还仍然存活的癌细胞，其在细胞表面表达蛋白A56，这使得能够进行靶向二次抗癌治疗。因此，在使用包含编码蛋白A56或其片段或变体的核酸的载体，和结合蛋白A56或其片段的抗体的情况下，可以有效地治疗癌症，其中每一个都是本发明的实施方式。
附图的简要说明
图1显示了使用含有编码蛋白A56或其片段的核酸的溶瘤病毒靶向肿瘤细胞的过程图。
图2显示了通过用含有编码蛋白A56的核酸的溶瘤病毒感染人肺癌细胞系(A549)，然后用免疫荧光染色鉴定蛋白A56是否在感染的A549癌细胞系的细胞表面上表达而获得的结果。
图3显示了通过用含有编码蛋白A56的核酸的溶瘤病毒感染人结肠直肠癌细胞系(HCT-116)，然后用免疫荧光染色鉴定蛋白A56是否在感染的HCT-116细胞系的细胞表面上表达而获得的结果。
图4显示了通过对移植了人结肠直肠癌细胞系(HT-29)的小鼠腹膜内施用含有编码蛋白A56的核酸的溶瘤病毒，然后鉴定蛋白A56在各组织表面上的表达而获得的结果。
图5显示了通过向正常兔腹膜内施用含有编码蛋白A56的核酸的溶瘤病毒，然后鉴定每个组织表面上蛋白A56的表达而获得的结果。
图6显示了通过对移植了小鼠肾癌细胞系(Renca)的小鼠肿瘤内施用含有编码蛋白A56的核酸的溶瘤病毒，然后在7、10和14天内鉴定蛋白A56在肿瘤组织表面上的表达而获得的结果。
图7显示了通过对移植了小鼠肾癌细胞系(Renca)的小鼠肿瘤内施用含有编码蛋白A56的核酸的溶瘤病毒和羟基脲，然后在第7、10和14天鉴定蛋白A56在肿瘤组织表面上的表达而获得的结果。
图8显示了通过对移植了小鼠肾癌细胞系(Renca)的小鼠进行二次施用包含编码蛋白A56的核酸的溶瘤病毒，然后在第21、24和28天鉴定蛋白A56在肿瘤组织表面上的表达所获得的结果。
图9显示了通过对移植了小鼠肾癌细胞系(Renca)的小鼠进行二次施用包含编码蛋白A56的核酸的溶瘤病毒和羟基脲，然后在第21、24和28天鉴定蛋白A56在肿瘤组织表面上的表达所获得的结果。
图10显示了通过对移植了小鼠肾癌细胞系(Renca)的小鼠施用含有编码蛋白A56的核酸和羟基脲的溶瘤病毒，然后测量小鼠肿瘤体积而获得的结果。
图11显示了通过对移植了小鼠肾癌细胞系(Renca)的小鼠施用含有编码蛋白A56的核酸和羟基脲的溶瘤病毒，然后测量小鼠体重而获得的结果。
图12示出了显示蛋白A56及其片段的实施方案的示意图。
图13显示了通过鉴定蛋白A56及其片段在细胞表面上的表达而获得的结果。
图14至19显示了通过测量制备的抗A56抗体与蛋白A56之间的亲和力而获得的结果。
图20A显示了测量抗体A56-01A02至A56-02B06的产量的结果。
图20B显示了抗体A56-01A02至A56-02B06的产量图。
图20C显示了测量抗体A56-02D04至A56-59E12的产量的结果。
图21至37显示了通过纯化产生的抗A56抗体，然后通过SDS-PAGE鉴定这些抗体而获得的结果。
图38显示了已用溶瘤病毒处理或未通过溶瘤病毒处理过的HeLa或HT-29细胞系，分别用五种抗A56抗体中的每一种进行处理，然后用流式细胞术进行测量而获得的结果。
图39显示了已用溶瘤病毒处理或未通过溶瘤病毒处理过的A549、MCF-7或PC-3细胞系，分别用三种抗A56抗体中的每一种进行处理，然后用流式细胞术进行测量而获得的结果。
图40示出了已经通过溶瘤病毒处理或未经溶瘤病毒处理的HeLa细胞系，用抗A56抗体(抗体在线，Antibodies-Online)进行处理，然后进行FACS分析而获得的结果。
图41示出了已经通过溶瘤病毒处理或未经溶瘤病毒处理的HeLa细胞系，用抗A56抗体(LakePharma变体3)进行处理，然后进行FACS分析而获得的结果。
图42示出了已经通过溶瘤病毒处理或未经溶瘤病毒处理的HeLa细胞系，用抗A56抗体(LakePharma变体4)进行处理，然后进行FACS分析而获得的结果。
图43示出了已经通过溶瘤病毒处理或未经溶瘤病毒处理的HeLa细胞系，用抗A56抗体(抗体在线、LakePharma变体3或LakePharma变体4)进行处理，然后进行FACS分析而获得的结果。
图44显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab18)进行处理，然后通过流式细胞术进行测量而获得的结果。
图45显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab19)进行处理，然后通过流式细胞术进行测量而获得的结果。
图46示出了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab101)处理，然后通过流式细胞术进行测量而获得的结果。
图47示出了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab13)处理，然后通过流式细胞术进行测量而获得的结果。
图48显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab14)处理，然后通过流式细胞术进行测量而获得的结果。
图49显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab08)处理，然后通过流式细胞术进行测量而获得的结果。
图50显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab03)处理，然后通过流式细胞术进行测量而获得的结果。
图51显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab51)处理，然后通过流式细胞术进行测量而获得的结果。
图52显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab55)处理，然后通过流式细胞术进行测量而获得的结果。
图53显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab16)处理，然后通过流式细胞术进行测量而获得的结果。
图54显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(LP变体3)处理，然后通过流式细胞术进行测量而获得的结果。
图55显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的A549癌细胞系，用抗A56抗体(LP变体4)处理，然后通过流式细胞术进行测量而获得的结果。
图56显示了已经或未经溶瘤病毒(OTS-412)处理的A549癌细胞系，用抗A56抗体(Ab18、Ab19、Ab01、Ab13、Ab14、Ab08、Ab03、Ab51、Ab55、Ab16)处理，然后通过流式细胞术进行测量而获得的结果。
图57显示了已经或未经溶瘤病毒(WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab18、Ab19、Ab01、Ab13、Ab14、Ab08、Ab03、Ab51、Ab55、Ab16)处理，然后通过流式细胞术进行测量而获得的结果。
图58显示了已经或未经溶瘤病毒(OTS-412)处理的A549癌细胞系，用抗A56抗体(Ab18、Ab16)处理，然后通过流式细胞术进行测量而获得的结果。
图59显示了已经或未经溶瘤病毒(WOTS-418)处理的A549癌细胞系，用抗A56抗体(Ab18、Ab16)处理，然后用流式细胞术进行测量而获得的结果。
图60显示了已经或未经溶瘤病毒(OTS-412)处理的A549癌细胞系，用LakePharma变体3或LakePharma变体4处理，然后用流式细胞术进行测量而获得的结果。
图61显示了已经或未经溶瘤病毒(WOTS-418)处理的A549癌细胞系，用LakePharma变体3或LakePharma变体4处理，然后用流式细胞术进行测量而获得的结果。
图62显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab18)处理，然后用流式细胞术进行测量而获得的结果。
图63显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab19)处理，然后用流式细胞术进行测量而获得的结果。
图64显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab01)处理，然后用流式细胞术进行测量而获得的结果。
图65显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab13)处理，然后用流式细胞术进行测量而获得的结果。
图66显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab14)处理，然后用流式细胞术进行测量而获得的结果。
图67显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab08)处理，然后用流式细胞术进行测量而获得的结果。
图68显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab03)处理，然后用流式细胞术进行测量而获得的结果。
图69显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab51)处理，然后用流式细胞术进行测量而获得的结果。
图70显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab55)处理，然后用流式细胞术进行测量而获得的结果。
图71显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab16)处理，然后用流式细胞术进行测量而获得的结果。
图72显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(LP变体3)处理，然后用流式细胞术进行测量而获得的结果。
图73显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的PC3癌细胞系，用抗A56抗体(LP变体4)处理，然后用流式细胞术进行测量而获得的结果。
图74显示了已经或未经溶瘤病毒(OTS-412)处理的PC3癌细胞系，用抗A56抗体(Ab18、Ab19、Ab01、Ab13、Ab14、Ab08、Ab03、Ab51、Ab55、Ab16)处理，然后用流式细胞术进行测量而获得的结果。
图75显示了已经或未经溶瘤病毒(WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab18、Ab19、Ab01、Ab13、Ab14、Ab08、Ab03、Ab51、Ab55、Ab16)处理，然后用流式细胞术进行测量而获得的结果。
图76显示了已经或未经溶瘤病毒(WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab18、Ab16)处理，然后用流式细胞术进行测量而获得的结果。
图77显示了已经或未经溶瘤病毒(WOTS-418)处理的PC3癌细胞系，用抗A56抗体(Ab18、Ab16)处理，然后用流式细胞术进行测量而获得的结果。
图78显示了已经或未经溶瘤病毒(OTS-412)处理的PC3癌细胞系，用LakePharma变体3或LakePharma变体4处理，然后用流式细胞术进行测量而获得的结果。
图79显示了已经或未经溶瘤病毒(WOTS-418)处理的PC3癌细胞系，用LakePharma变体3或LakePharma变体4处理，然后用流式细胞术进行测量而获得的结果。
图80显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(Ab18)处理，然后用流式细胞术进行测量而获得的结果。
图81显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(Ab19)处理，然后用流式细胞术进行测量而获得的结果。
图82显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(Ab01)处理，然后用流式细胞术进行测量而获得的结果。
图83显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(Ab13)处理，然后用流式细胞术进行测量而获得的结果。
图84显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(Ab14)处理，然后用流式细胞术进行测量而获得的结果。
图85显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(Ab08)处理，然后用流式细胞术进行测量而获得的结果。
图86显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(Ab03)处理，然后用流式细胞术进行测量而获得的结果。
图87显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(Ab51)处理，然后用流式细胞术进行测量而获得的结果。
图88显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(Ab55)处理，然后用流式细胞术进行测量而获得的结果。
图89显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(Ab16)处理，然后用流式细胞术进行测量而获得的结果。
图90显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(LP变体3)处理，然后用流式细胞术进行测量而获得的结果。
图91显示了已经或未经溶瘤病毒(OTS-412、WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(LP变体4)处理，然后用流式细胞术进行测量而获得的结果。
图92显示了已经或未经溶瘤病毒(OTS-412)处理的MCF7癌细胞系，用抗A56抗体(Ab18、Ab19、Ab01、Ab13、Ab14、Ab08、Ab03、Ab51、Ab55、Ab16)处理，然后用流式细胞术进行测量而获得的结果。
图93显示了已经或未经溶瘤病毒(WOTS-418)处理的MCF7癌细胞系，用抗A56抗体(Ab18、Ab19、Ab01、Ab13、Ab14、Ab08、Ab03、Ab51、Ab55、Ab16)处理，然后用流式细胞术进行测量而获得的结果。
图94显示了已经或未经溶瘤病毒(OTS-412)处理的MCF7癌细胞系，用LakePharma变体3或LakePharma变体4处理，然后用流式细胞术进行测量而获得的结果。
图95显示了已经或未经溶瘤病毒(WOTS-418)处理的MCF7癌细胞系，用LakePharma变体3或LakePharma变体4处理，然后用流式细胞术进行测量而获得的结果。
图96显示了通过使用制备的抗体进行ELISA而获得的结果。
图97显示了通过鉴定融合Fc的A56融合蛋白的表达水平而获得的结果。
图98显示了通过鉴定制备的A56片段的表达水平而获得的结果。
图99显示了通过分析关于溶瘤病毒(OTS-412和WOTS-418)中的蛋白A56的序列同源性而获得的结果。
实施本发明的最佳模式
在下文中，将详细描述本发明。
在本发明的一个方面，提供了一种抗癌剂，其包含特异性结合蛋白A56或其片段的抗体或其片段作为活性成分。
如本文所用，术语“蛋白A56”是指从由A56、A56R或HA为代表的基因(例如，基因ID：3707652)翻译的蛋白，当宿主细胞被痘病毒科病毒感染后其在痘病毒科病毒的基因中被编码。蛋白A56或其片段可包括由SEQ ID NO:1038、1040、1042、1044、1046、1048、1050、1052、1054、1056、1058、1060、1073、1075、1077或1079所示的氨基酸序列。编码蛋白A56或其片段的核酸可以包括由SEQ ID NO:1039、1041、1043、1045、1047、1049、1051、1053、1055、1057、1059、1061、1072、1074、1076或1078所示的核苷酸序列。
具体地，蛋白A56可以是野生型蛋白A56或其变体。野生型蛋白A56可以具有由SEQID NO:1038或1073所示的氨基酸序列。另外，编码野生型蛋白A56的核酸可以是由SEQ IDNO:1039或1072所示的核苷酸序列。
此外，蛋白A56变体可以经过一个或多个氨基酸的取代、缺失或添加，只要该变体可以像蛋白A56一样位于癌细胞表面上。编码蛋白A56变体的核苷酸序列可以是与编码SEQID NO:1038或1073所示的氨基酸序列具有至少60％、至少70％、至少80％或至少90％的序列同源性的核苷酸序列，并且可以最优选地是编码与其具有至少95％的序列同源性的氨基酸序列的核苷酸序列。具体地，蛋白A56变体可以包括由SEQ ID NO:1075或1079所示的氨基酸序列。编码蛋白A56变体的核酸可以包括由SEQ ID NO:1074或1078所示的核苷酸序列。
蛋白A56片段可以是包含由SEQ ID NO:1040、1042、1044、1046、1048、1050、1052、1054、1056、1058、1060或1077所示的氨基酸序列的多肽。此外，编码该片段的核苷酸序列可以是编码由SEQ ID NO:1040、1042、1044、1046、1048、1050、1052、1054、1056、1058、1060或1076所示的多肽的核苷酸序列。具体地，编码由SEQ ID NO:1040、1042、1044、1046、1048、1050、1052、1054、1056、1058、1060或1077所示的多肽的核苷酸序列可以按上述顺序由SEQID NO:1041、1043、1045、1047、1049、1051、1053、1055、1057、1059、1061或1076表示。
此外，编码蛋白A56片段的核苷酸序列可以是与编码由SEQ ID NO:1040、1042、1044、1046、1048、1050、1052、1054、1056、1058、1060或1077所示的氨基酸序列具有至少60％、至少70％、至少80％或至少90％的序列同源性的氨基酸序列的核苷酸序列，并且最优选地是编码与其具有至少95％的序列同源性的氨基酸序列的核苷酸序列。
如本文所用，术语“抗体”是指与抗原结合并干扰其作用或去除抗原的免疫蛋白。有五种类型的抗体：IgM、IgD、IgG、IgA和IgE，每一种都含有由重链恒定区基因μ、δ、γ、α或ε产生的重链。在抗体技术中，主要使用IgG。IgG包括IgG1、IgG2、IgG3和IgG4四种同种型，每种可能具有不同的结构和功能特性。
IgG形成由两条重链(约50kDa)蛋白和两条轻链(约25kDa)蛋白组成的非常稳定的Y形结构(分子量：约150kDa)。抗体具有轻链和重链，每条链分为抗体间氨基酸序列不同的可变区和抗体间氨基酸序列相同的恒定区。重链恒定区包括CH1、H(铰链)、CH2、CH3结构域。每个结构域由两个β-折叠组成，这些结构域通过分子内二硫键连接。重链和轻链中的两个可变区结合在一起形成抗原结合位点。该位点存在于Y形的两个臂中。在Y形中，能够与抗原结合的部分称为抗体结合片段(Fab)，不与抗原结合的部分称为可结晶片段(Fc)。Fab和Fc通过柔性铰链区连接。
如本文所用，术语“CDR”是指与抗原结合的位点，该位点是抗体重链和轻链可变区中存在的高变区，并且其氨基酸序列因抗体而异。从抗体的三维结构来看，CDR在抗体表面呈环状；在环下方，有一个在结构上支持CDR的框架区(FR)。每一个重链和轻链中都具有三个环结构，这六个环区结构相互结合以与抗原直接接触。为方便起见，六个环区结构上的抗原结合位点分别称为CDR1、CDR2、CDR3、CDR4、CDR5和CDR6。
此外，抗体片段可以是选自下组的任何一种：Fab、scFv、F(ab)2和Fv。抗体片段是指抗原结合结构域，不包括具有将抗原结合刺激传递至细胞、补体等的效应子功能的可结晶区(Fc区)，并且可以包括第三代抗体片段，例如单域抗体或微抗体。
此外，该抗体片段具有以下优点：抗体片段比完全结构的IgG小，从而提高了对组织或肿瘤的渗透性；并且抗体片段可以在细菌中产生，降低了生产成本。此外，该抗体片段不具有Fc，因此用于不希望将抗原结合刺激传递至细胞、补体等的功能的情况下。该抗体片段在人体内的半衰期短，因此适用于体内诊断；但是，替换构成抗体的氨基酸中的一些碱性、酸性或中性氨基酸可能会改变抗体的独特等电点(pI)。抗体等电点的这种变化可以引起包括例如降低抗体的体内毒副作用或增加抗体的水溶性的变化。因此，对于治疗性抗体，考虑到亲和力或结构形式，可以使用完全结构的IgG。
该抗体可以通过已知的单克隆抗体生产技术容易地生产。生产单克隆抗体的方法可以通过使用从免疫动物获得的B淋巴细胞制备杂交瘤来进行，或者可以通过使用噬菌体展示技术来进行。然而，本发明不限于此。
所述抗体或其片段可以包括：
重链可变区(VH)，包括选自下组的重链CDR1：SEQ ID NO:1、18、35、52、69、86、103、120、137、154、171、188、205，222、239、256、273、290、307、324、341、358、375、392、409、426、443、460、477、494、511、528、545、562、579、596、613、630、647、664、681、698、715、732、749、766、783、800、817、834、851、868、885、902、919、936、953、970、987、1004、1023、1062和1063；
选自下组的重链CDR2：SEQ ID NO:2、19、36、53、70、87、104、121、138、155、172、189、206、223、240、257、274、291、308、325、342、359、376、393、410、427、444、461、478、495、512、529、546、563、580、597、614、631、648、665、682、699、716、733、750、767、784、801、818、835、852、869、886、903、920、937、954、971、988、1005、1022和1064；和
选自下组的重链CDR3：SEQ ID NO:3、20、37、54、71、88、105、122、139、156、173、190、207、224、241、258、275、292、309、326、343、360、377、394、411、428、445、462、479、496、513、530、547、564、581、598、615、632、649、666、683、700、717、734、751、768、785、802、819、836、853、870、887、904、921、938、955、972、989、1006、1023和1065；和
轻链可变区(VL)，包括选自下组的轻链CDR1：SEQ ID NO:4、21、38、55、72、89、106、123、140、157、174、191、208、225、242、259、276、293、310、327、344、361、378、395、412、429、446、463、480、497、514、531、548、565、582、599、616、633、650、667、684、701、718、735、752、769、786、803、820、837、854、871、888、905、922、939、956、973、990、1007、1024和1066；
选自下组的轻链CDR2：SEQ ID NO:5、22、39、56、73、90、107、124、141、158、175、192、209、226、243、260、277、294、311、328、345、362、379、396、413、430、447、464、481、498、515、532、549、566、583、600、617、634、651、668、685、702、719、736、753、770、787、804、821、838、855、872、889、906、923、940、957、974、991、1008、1025和1067；和
选自下组的轻链CDR3：SEQ ID NO:6、23、40、57、74、91、108、125、142、159、176、193、210、227、244、261、278、295、312、329、346、363、380、397、414、431、448、465、482、499、516、533、550、567、584、601、618、635、652、669、686、703、720、737、754、771、788、805、822、839、856、873、890、907、924、941、958、975、992、1009、1026和1068。
所述抗体或其片段可以包括：
重链可变区(VH)，包括具有SEQ ID NO:1、35、120、222、239、290、324、341、851、919、1062或1063所示的氨基酸序列的重链CDR1；
具有SEQ ID NO:2、36、121、223、240、291、325、342、852、920或1064所示的氨基酸序列的重链CDR 2；和
具有SEQ ID NO:3、37、122、224、241、292、326、343、853、921或1065所示的氨基酸序列的重链CDR3；和
轻链可变区(VL)，包括具有SEQ ID NO:4、38、123、225、242、293、327、344、854、922或1066所示氨基酸序列的轻链CDR1；
具有SEQ ID NO:5、39、124、226、243、294、328、345、855、923或1067所示的氨基酸序列的轻链CDR2；和
具有SEQ ID NO:6、40、125、227、244、295、329、346、856、924或1068所示的氨基酸序列的轻链CDR3。
所述抗体或其片段可以包括重链可变区(VH)，其包括具有SEQ ID NO:1的氨基酸序列的重链CDR1；具有SEQ ID NO:2的氨基酸序列的重链CDR2；以及具有SEQ ID NO:3的氨基酸序列的重链CDR3；和轻链可变区(VL)，其包括具有SEQ ID NO:4的氨基酸序列的轻链CDR1；具有SEQ ID NO:5的氨基酸序列的轻链CDR2；以及具有SEQ ID NO:6的氨基酸序列的轻链CDR3。
所述抗体或其片段可以包括重链可变区(VH)，其包括具有SEQ ID NO:35的氨基酸序列的重链CDR1；具有SEQ ID NO:36的氨基酸序列的重链CDR2；以及具有SEQ ID NO:37的氨基酸序列的重链CDR3；和轻链可变区(VL)，其包括具有SEQ ID NO:38的氨基酸序列的轻链CDR1；具有SEQ ID NO:39的氨基酸序列的轻链CDR2；以及具有SEQ ID NO:40的氨基酸序列的轻链CDR3。
所述抗体或其片段可以包括重链可变区(VH)，其包括具有SEQ ID NO:120的氨基酸序列的重链CDR1；具有SEQ ID NO:121的氨基酸序列的重链CDR2；以及具有SEQ ID NO:122的氨基酸序列的重链CDR3；和轻链可变区(VL)，其包括具有SEQ ID NO:123的氨基酸序列的轻链CDR1；具有SEQ ID NO:124的氨基酸序列的轻链CDR2；以及具有SEQ ID NO:125的氨基酸序列的轻链CDR3。
所述抗体或其片段可以包括重链可变区(VH)，其包括具有SEQ ID NO:222的氨基酸序列的重链CDR1；具有SEQ ID NO:223的氨基酸序列的重链CDR2；以及具有SEQ ID NO:224的氨基酸序列的重链CDR3；和轻链可变区(VL)，其包括具有SEQ ID NO:225的氨基酸序列的轻链CDR1；具有SEQ ID NO:226的氨基酸序列的轻链CDR2；以及具有SEQ ID NO:227的氨基酸序列的轻链CDR3。
所述抗体或其片段可以包括重链可变区(VH)，其包括具有SEQ ID NO:239的氨基酸序列的重链CDR1；具有SEQ ID NO:240的氨基酸序列的重链CDR2；以及具有SEQ ID NO:241的氨基酸序列的重链CDR3；和轻链可变区(VL)，其包括具有SEQ ID NO:242的氨基酸序列的轻链CDR1；具有SEQ ID NO:243的氨基酸序列的轻链CDR2；以及具有SEQ ID NO:244的氨基酸序列的轻链CDR3。
所述抗体或其片段可以包括重链可变区(VH)，其包括具有SEQ ID NO:290的氨基酸序列的重链CDR1；具有SEQ ID NO:291的氨基酸序列的重链CDR2；以及具有SEQ ID NO:292的氨基酸序列的重链CDR3；和轻链可变区(VL)，其包括具有SEQ ID NO:293的氨基酸序列的轻链CDR1；具有SEQ ID NO:294的氨基酸序列的轻链CDR2；以及具有SEQ ID NO:295的氨基酸序列的轻链CDR3。
所述抗体或其片段可以包括重链可变区(VH)，其包括具有SEQ ID NO:324的氨基酸序列的重链CDR1；具有SEQ ID NO:325的氨基酸序列的重链CDR2；以及具有SEQ ID NO:326的氨基酸序列的重链CDR3；和轻链可变区(VL)，其包括具有SEQ ID NO:327的氨基酸序列的轻链CDR1；具有SEQ ID NO:328的氨基酸序列的轻链CDR2；以及具有SEQ ID NO:329的氨基酸序列的轻链CDR3。
所述抗体或其片段可以包括重链可变区(VH)，其包括具有SEQ ID NO:341的氨基酸序列的重链CDR1；具有SEQ ID NO:342的氨基酸序列的重链CDR2；以及具有SEQ ID NO:343的氨基酸序列的重链CDR3；和轻链可变区(VL)，其包括具有SEQ ID NO:344的氨基酸序列的轻链CDR1；具有SEQ ID NO:345的氨基酸序列的轻链CDR2；以及具有SEQ ID NO:346的氨基酸序列的轻链CDR3。
所述抗体或其片段可以包括重链可变区(VH)，其包括具有SEQ ID NO:851的氨基酸序列的重链CDR1；具有SEQ ID NO:852的氨基酸序列的重链CDR2；以及具有SEQ ID NO:853的氨基酸序列的重链CDR3；和轻链可变区(VL)，其包括具有SEQ ID NO:854的氨基酸序列的轻链CDR1；具有SEQ ID NO:855的氨基酸序列的轻链CDR2；以及具有SEQ ID NO:856的氨基酸序列的轻链CDR3。
所述抗体或其片段可以包括重链可变区(VH)，其包括具有SEQ ID NO:919的氨基酸序列的重链CDR1；具有SEQ ID NO:920的氨基酸序列的重链CDR2；以及具有SEQ ID NO:921的氨基酸序列的重链CDR3；和轻链可变区(VL)，其包括具有SEQ ID NO:922的氨基酸序列的轻链CDR1；具有SEQ ID NO:923的氨基酸序列的轻链CDR2；以及具有SEQ ID NO:924的氨基酸序列的轻链CDR3。
所述抗体或其片段可以包括重链可变区(VH)，其包括具有SEQ ID NO:1062或1063的氨基酸序列的重链CDR1；具有SEQ ID NO:1064的氨基酸序列的重链CDR2；以及具有SEQID NO:1065的氨基酸序列的重链CDR3；和轻链可变区(VL)，其包括具有SEQ ID NO:1066的氨基酸序列的轻链CDR1；具有SEQ ID NO:1067的氨基酸序列的轻链CDR2；以及具有SEQ IDNO:1068的氨基酸序列的轻链CDR3。
在一个实施方式中，所述抗体或其片段可以包括以下CDR组合：
[表1]
特别地，所述抗体或其片段可以包括具有选自下组中的任何一种氨基酸序列的重链可变区：SEQ ID NO:8、25、42、59、76、93、110、127、144、161、178、195、212、229、246、263、280、297、314、331、348、365、382、399、416、433、450、467、484、501、518、535、552、569、586、603、620、637、654、671、688、705、722、739、756、773、790、807、824、841、858、875、892、909、926、943、960、977、994、1011、1028、1069和1070。
具体地，所述抗体或其片段可以包括具有选自下组中的任意一种氨基酸序列的重链可变区：SEQ ID NO:8、42、127、229、246、297、331、348、858、926、1069和1070。
此外，该抗体或其片段可以包括具有选自下组中的任意一种氨基酸序列的轻链可变区：SEQ ID NO:9、26、43、60、77、94、111、128、145、162、179、196、213、230、247、264、281、298、315、332、349、366、383、400、417、434、451、468、485、502、519、536、553、570、587、604、621、638、655、672、689、706、723、740、757、774、791、808、825、842、859、876、893、910、927、944、961、978、995、1012、1029和1071。
具体地，所述抗体或其片段可以包括具有选自下组中的任意一种氨基酸序列的轻链可变区：SEQ ID NO:9、43、128、230、247、298、332、349、859、927、1071。
所述抗体或其片段可以包括具有选自下组中的任意一种氨基酸序列的重链可变区：SEQ ID NO:8、25、42、59、76、93、110、127、144、161、178、195、212、229、246、263、280、297、314、331、348、365、382、399、416、433、450、467、484、501、518、535、552、569、586、603、620、637、654、671、688、705、722、739、756、773、790、807、824、841、858、875、892、909、926、943、960、977、994、1011、1028、1069和1070；以及选自下组中的任意一种氨基酸序列的轻链可变区：SEQ ID NO:9、26、43、60、77、94、111、128、145、162、179、196、213、230、247、264、281、298、315、332、349、366、383、400、417、434、451、468、485、502、519、536、553、570、587、604、621、638、655、672、689、706、723、740、757、774、791、808、825、842、859、876、893、910、927、944、961、978、995、1012、1029和1071。
具体地，所述抗体或其片段可以包括具有选自下组中的任意一种氨基酸序列的重链可变区：SEQ ID NO:8、42、127、229、246、297、331、348、858、926、1069和1070；以及选自下组中的任意一种氨基酸序列的轻链可变区：SEQ ID NO:9、43、128、230、247、298、332、349、859、927和1071。
抗癌剂可以靶向感染溶瘤病毒的癌细胞。具体而言，溶瘤病毒可以是溶瘤牛痘病毒。溶瘤病毒可以含有编码蛋白A56或其片段的核酸。
蛋白A56或其片段如上所述。蛋白A56可以是野生型蛋白A56或蛋白A56的变体。编码A56蛋白或其片段的核酸可以是编码野生型A56蛋白或A56蛋白变体的核酸。
编码蛋白A56或其片段的核酸可以包括由SEQ ID NO:1039、1041、1043、1045、1047、1049、1051、1053、1055、1057、1059、1061、1072、1074、1076或1078所示的核苷酸序列。
牛痘病毒可以是但不限于以下牛痘病毒株之一：西部保留地(Western Reserve，WR)、纽约牛痘病毒(NYVAC)、惠氏(Wyeth，纽约市卫生局；NYCBOH)、LC16m8、李斯特(Lister)、哥本哈根、天坛(Tian Tan)、USSR、塔什干(TashKent)、埃文斯(Evans)、国际卫生部-J(International Health Division-J，IHD-J)和国际卫生部-怀特(InternationalHealth Division-White，IHD-W)。
溶瘤病毒是一种胸苷激酶(TK)基因缺失的病毒。具体而言，溶瘤病毒可以是一种缺失胸苷激酶基因的重组牛痘病毒。
如本文所用，术语“胸苷激酶(TK)”是指称为胸苷激酶并参与核苷酸生物合成的酶。TK是一种用于细胞和病毒中核苷酸生物合成的酶。这里，对于细胞而言，正常细胞不再分裂，因此其中不存在TK；甚至对于快速分裂的细胞，如毛囊细胞，TK的存在量也不足以让病毒利用。从这些观点来看，病毒中TK基因的删除，使得病毒只有在TK存在的癌细胞存在时才能增殖，从而选择性地杀死癌细胞。
抗癌剂还可以包含生理上可接受的载体。此外，抗癌剂还可以包含通常用于制备药物组合物的合适的赋形剂和稀释剂。此外，抗癌剂可以按照常规方法制成散剂、颗粒剂、片剂、胶囊剂、混悬剂、乳剂、糖浆剂和气雾剂等口服剂型、外用剂、栓剂、或注射剂等形式来使用。具体地，抗癌剂可以是注射剂的形式。本领域已知的合适制剂可以是文献中公开的那些(《雷明顿医药科学》，1985)。
抗癌剂可用于预防或治疗选自下组的癌症：肺癌、结直肠癌、前列腺癌、甲状腺癌、乳腺癌、脑癌、头颈癌、食道癌、皮肤癌、胸腺癌、胃癌、结肠癌、肝癌、卵巢癌、子宫癌、膀胱癌、直肠癌、胆囊癌、胆道癌、胰腺癌、淋巴瘤、急性白血病、多发性骨髓瘤或其组合。此外，对于抗癌剂，载体、赋形剂和稀释剂的实例可以包括氯化钠、乳糖、葡萄糖、蔗糖、山梨糖醇、甘露糖醇、木糖醇、赤藓糖醇、麦芽糖醇、淀粉、阿拉伯树胶、藻酸盐、明胶、钙磷酸盐、硅酸钙、纤维素、甲基纤维素、微晶纤维素、聚乙烯吡咯烷酮、水、羟基苯甲酸甲酯、羟基苯甲酸丙酯、滑石、硬脂酸镁、矿物油等。在配制抗癌剂的情况下，可以使用常用的例如填充剂、增量剂、粘合剂、润湿剂、崩解剂和表面活性剂等稀释剂或赋形剂进行制备。
用于肠胃外给药的制剂可以包括无菌水溶液、非水溶剂、混悬剂、乳剂、冻干制剂、栓剂等。对于非水溶剂和混悬剂，可以使用丙二醇、聚乙二醇、植物油如橄榄油、注射用酯如油酸乙酯等。作为栓剂的基质，可以使用Witepsol、聚乙二醇、吐温61、可可脂、月桂脂、甘油明胶等。
癌症可以是实体癌或血癌。具体地，实体癌可以是选自下组中的任一种：肺癌、结直肠癌、前列腺癌、甲状腺癌、乳腺癌、脑癌、头颈癌、食道癌、皮肤癌、胸腺癌、胃癌、结肠癌、肝癌、卵巢癌、子宫癌、膀胱癌、直肠癌、胆囊癌、胆道癌、胰腺癌或其组合。此外，血癌可以是选自下组中的任一种：淋巴瘤、急性白血病、多发性骨髓瘤或其组合。
抗癌剂的给药量可以优选地根据患者的年龄、性别、症状、活性成分在体内的吸收量、灭活率、组合使用的药物等来确定。抗癌剂可以基于抗体或其片段按照0.0001mg/kg(体重)至100mg/kg(体重)施用。
在本发明的另一个方面，提供了一种溶瘤病毒，其包含编码蛋白A56或其片段的核酸。
在本发明的另一个方面，提供了一种用于靶向癌细胞的组合物，其包含作为活性成分的溶瘤病毒，所述溶瘤病毒含有编码蛋白A56或其片段的核酸。溶瘤病毒如上述抗癌剂中所述。
癌细胞可以是实体癌或血癌的细胞。具体地，所述实体癌可以是但不限于选自下组中的任一种：肺癌、结直肠癌、前列腺癌、甲状腺癌、乳腺癌、脑癌、头颈癌、食道癌、皮肤癌、胸腺癌、胃癌、结肠癌、肝癌、卵巢癌、子宫癌、膀胱癌、直肠癌、胆囊癌、胆道癌、胰腺癌、肾癌、纤维肉瘤、睾丸癌、脑转移瘤、肝转移瘤、或其组合。
此外，血癌可以是但不限于选自下组中的任一种：淋巴瘤、急性白血病、多发性骨髓瘤、或其组合。
在本发明的又一方面，提供了一种靶向癌细胞的方法，包括将溶瘤病毒施用于受试者的步骤。
受试者可以是哺乳动物，包括人，并且可以是非人类动物。术语“非人类动物”是指任何脊椎动物并且可以包括哺乳动物和非哺乳动物，例如非人类灵长类动物、羊、狗、猫、马、牛、鸡、两栖动物和爬行动物。此外，受试者是指患有癌症疾病，或通过施用溶瘤病毒可以缓解、抑制或治疗该疾病的个体。
溶瘤病毒的剂量根据个体的病症和体重、疾病严重程度、药物类型、给药途径和给药时间的不同而变化，并且可以由本领域技术人员适当地选择。患者接受溶瘤病毒的剂量为1×105到1×1018病毒颗粒、传染性病毒单位(TCID50)或噬斑形成单位(pfu)。具体而言，患者接受溶瘤病毒的剂量为1×105、2×105、5×105、1×106、2×106、5×106、1×107、2×107、5×107、1×108、2×108、5×108、1×109、2×109、5×109、1×1010、5×1010、1×1011、5×1011、1×1012、1×1013、1×1014、1×1015、1×1016、1×1017或更高的病毒颗粒、传染性病毒单位或噬斑形成单位，以及在上述数值之间的各种数值和范围也可以包括在其中。优选地，溶瘤病毒的施用剂量为1×105至1×1010pfu。更优选地，溶瘤病毒可以以等于或大于1×105且小于1×109pfu的剂量施用。
溶瘤病毒可以肠胃外给药，并且这种给药可以通过任何合适的方法进行，例如肿瘤内、腹膜内、皮下、皮内、节间或静脉内给药。其中，优选肿瘤内、腹膜内或静脉内给药。
关于给药途径、剂量和给药频率，溶瘤病毒可以多种方式和数量施用于患者，这取决于患者的病症和有无副作用的存在。并且本领域技术人员可以在合适的范围内选择最佳的给药途径、剂量和给药频率。此外，溶瘤病毒可以与其他药物或对所治疗疾病的治疗效果已知的生理活性物质组合施用，或者可以与其他药物以组合制剂的形式进行给药。具体而言，溶瘤病毒可以以注射剂的形式提供。
在本发明的又一方面，提供了与蛋白A56或其片段结合的抗体或其片段。抗体或其片段如上述抗癌剂中所述。
抗体可以通过制备抗体的方法制备，包括以下步骤：i)将蛋白A56或其片段施用于个体；ii)从所述个体获得B细胞；和iii)培养B细胞以获得重组抗蛋白A56抗体。
此外，蛋白A56或其片段可以通过制备蛋白的方法制备，包括以下步骤：i)将本发明的载体转染到宿主细胞中；ii)培养转染的宿主细胞；和iii)从培养物中获得重组蛋白A56。
宿主细胞可以是原核细胞或真核细胞。具体地，原核细胞可以是大肠杆菌或酵母细胞。真核细胞可以是NS/0骨髓瘤细胞、293细胞、中国仓鼠卵巢细胞(CHO细胞)、HeLa细胞、CapT细胞(人羊水来源的细胞)或COS细胞。
转染可以通过瞬时转染、显微注射、转导、细胞融合、磷酸钙沉淀、脂质体介导的转染、DEAE-葡聚糖介导的转染、聚凝胺介导的转染、电穿孔或基因枪来进行。
在本发明的又一方面，提供了一种癌症靶向多肽或其片段，该多肽包括由SEQ IDNO:1038、1040、1042、1044、1046、1048、1050、1052、1054、1056、1058、1060、1073、1075、1077或1079所示的氨基酸序列。包括由SEQ ID NO:1038、1040、1042、1044、1046、1048、1050、1052、1054、1056、1058、1060、1073、1075、1077或1079所示的氨基酸序列的所述多肽或其片段如上述抗癌剂中所述。
在本发明的又一方面，提供了编码癌症靶向多肽或其片段的分离的核酸。所述核酸可以包括由SEQ ID NO:1039、1041、1043、1045、1047、1049、1051、1053、1055、1057、1059、1061、1072、1074、1076或1078所示的核苷酸序列。
在本发明的再一方面，提供了一种用于治疗癌症的试剂盒，包括溶瘤病毒和抗体或其片段。
溶瘤病毒和抗体或其片段如上述抗癌剂中所述。
个体是指患有或正在患有可通过施用溶瘤病毒和抗体或其片段而得到缓解、抑制或治疗的疾病的个体。个体可以是哺乳动物，包括人，并且可以是非人类动物。术语“非人类动物”是指任何脊椎动物，并且可以包括哺乳动物和非哺乳动物，例如非人类灵长类动物、羊、狗、猫、马、牛、鸡、两栖动物和爬行动物。在溶瘤病毒被包含于用于癌细胞杀伤和靶向的第一组合物中并施用于个体的情况下，溶瘤病毒主要以特异性的方式仅杀死癌细胞；在溶瘤病毒中存活下来的癌细胞在细胞表面表达A56蛋白，这使得靶向二次抗癌治疗成为可能。
在抗体或其片段包含于用于二次抗癌治疗的第二组合物中并施用于个体的情况下，该抗体或其片段能仅二次杀死在细胞表面表达蛋白A56的癌细胞。
第一组合物和第二组合物可以药学有效量施用以治疗癌细胞或其转移，或抑制癌症生长。药学有效量可能会因癌症类型、患者年龄和体重、症状的性质和严重程度、当前治疗的类型、治疗次数、剂型和途径等各种因素而有所不同，并且可以由相关领域的专家容易地确定。
第一组合物和第二组合物可以肠胃外给药，并且这种给药可以通过任何合适的方法进行，例如肿瘤内、腹膜内、皮下、皮内、结内或静脉内给药。其中，优选肿瘤内、腹膜内或静脉内给药。另一方面，药物组合物的剂量可以根据给药方案、剂量、患者的健康状况等来确定。
在本发明的又一方面，提供了一种用于靶向癌症的药物组合物，其包含溶瘤病毒。所述溶瘤病毒如上述抗癌剂中所述。
在本发明的又一方面，提供了溶瘤病毒用于靶向癌症的用途。在本发明的又一方面，提供了一种靶向癌症的方法，包括将溶瘤病毒施用于个体的步骤。所述溶瘤病毒如上述抗癌剂中所述。
在本发明的又一方面，提供了溶瘤病毒和抗体或其片段在治疗癌症中的用途。溶瘤病毒和抗体或其片段如上述抗癌剂中所述。
在本发明的又一方面，提供了一种治疗癌症的方法，包括以下步骤：i)将溶瘤病毒施用于个体；和ii)将抗体或其片段施用于个体。溶瘤病毒和抗体或其片段如上述抗癌剂中所述。
发明方式
在下文中，将通过以下实施例更详细地描述本发明。然而，以下实施例仅用于说明目的，本发明的范围不限于此。
I.含有编码蛋白A56或其片段的核酸的溶瘤病毒的制备及其在肿瘤细胞表面表达的鉴定
制备例1.1蛋白A56变体的制备和鉴定
野生型牛痘病毒(纽约市卫生部毒株，VR-1536)购自美国典型培养物保藏中心(ATCC)。对于重组，使用带有HSV1-TK基因(pSE/L启动子)和萤火虫荧光素酶报告基因(p7.5启动子)基因的pUC57amp+(GENEWIZ，美国)作为穿梭质粒载体。
为了获得重组病毒，将HeLa细胞(ATCC)以每孔4×105个细胞接种在6孔板中，然后在含有10％胎牛血清的EMEM培养基中制备。使用野生型牛痘病毒以0.05的MOI进行处理。2小时后，将培养基更换为含有2％胎牛血清的EMEM培养基，然后使用XfectTM聚合物(Clonetech 631317，美国)将4μg已线性化的穿梭质粒载体转移到细胞中。培养4小时。随后，将培养基更换为含2％胎牛血清的EMEM培养基，继续培养72小时。通过检测HeLa细胞中的荧光素酶活性，获得含有HSV1-TK基因的重组牛痘病毒。
然后，通过在施加生化环境(TK-选择压力)的状态下进行10次连续继代培养来诱导HSV1-TK的突变，所述生化环境使得在TK-骨肉瘤(143TK-)细胞系中选择在BrdU(胸苷类似物，15μg/ml)存在下缺乏TK功能的细胞。向Macrogen(韩国首尔)提出了对突变牛痘病毒进行氨基酸测序的请求。结果，确定了突变的牛痘病毒的HSV1-TK的C末端的第46位氨基酸，编码谷氨酰胺(Gln)的密码子(caa)被点突变为终止密码子。另外，确认了突变的牛痘病毒的HSV1-TK的C末端46位之后的氨基酸残基缺失。最后，获得了具有遗传稳定性的表达HSV1-TK片段的突变牛痘病毒(OTS-412)。
此外，在HSV-TK中报道最多的突变是由碱基插入或缺失引起的移码突变，这些碱基发生在430至436位(7Gs)和548至583位(6Cs)的核苷酸序列部分。野生型HSV-TK插入牛痘病毒后，98％或更高的突变发生在这些部分中。因此，为了在核酸序列部分产生沉默突变，将430～436位的核酸序列GGGGGGGG变为GGTGGGTG，将548～583位的核酸序列CCCCCC变为CCCCTC。此外，HSV-TK变体基因，其中HSV-TK氨基酸序列中第167位的丙氨酸被改造为编码酪氨酸，被用作穿梭载体。然后，使用穿梭载体和Western Reserve株(WOTS-418)牛痘病毒以与OTS-412相同的方式生产重组牛痘病毒。
向Macrogen提出了对OTS-412和WOTS-418中的蛋白A56进行基因测序的请求。关于OTS-412和WOTS-418中各自的蛋白A56序列，通过NCBI Blast和Uniprot进行比对。结果，没有找到100％相同的序列；特别是，确认245～250位的氨基酸缺失。进行了与具有高度序列同源性的4个其他菌株的比较(图99)。
制备例1.2.含有编码蛋白A56或其片段的核酸的溶瘤病毒载体的构建
野生型痘病毒(纽约市卫生部实验室)购自美国典型培养物保藏中心(ATCC；VR-1536)。在该病毒中，通过同源重组敲除胸苷激酶基因，并用报告基因和编码蛋白A56或其片段的基因(SEQ ID NO:1039、1041、1043、1045、1047、1049、1051、1053、1055、1057、1059或1061、1072、1074(OTS-412-A56)、1076、1078(WOTS-418-A56)替代。
制备例1.3.含有编码蛋白A56或其片段的核酸的溶瘤病毒的制备为了制备含有蛋白A56的溶瘤病毒，将HeLaS3(ATCC)细胞系以每孔4×105个细胞接种在6孔板中，然后在含有10％胎牛血清的EMEM培养基中制备。使用野生型牛痘病毒以0.05的MOI进行处理。2小时后，换成含有2％胎牛血清的EMEM培养基，然后用Xfect试剂缓冲液将4μg制备例1.1中构建的溶瘤病毒载体转染到细胞中。培养4小时。随后，将培养基更换为含2％胎牛血清的EMEM培养基，继续培养72小时。最后收集感染细胞，重复冻融3次。通过超声裂解细胞，并使用蔗糖缓冲法获得含有编码蛋白A56或其片段的核酸的游离溶瘤病毒。
实验例1.蛋白A56在癌细胞表面的表达
将制备例1.3中制备的含有编码蛋白A56或其片段的核酸的溶瘤病毒用于感染人肺癌细胞系(A549)或人结肠直肠癌细胞系(HCT-116)，以确定蛋白A56是否在癌细胞表面表达。
具体而言，将A549(肺癌，ATCC，美国)或HCT-116(结直肠癌，韩国细胞系库)细胞系以3.5×104个细胞/孔接种在12孔板中的盖玻片上。随后，细胞用溶瘤病毒以0.1的MOI进行感染，然后在37℃和5％CO2的条件下孵育30小时。收获每个孵育的细胞系。然后，用4％(v/v)多聚甲醛(PFA)、1％(v/v)BSA、按1:500的比例稀释的抗A56一抗(货号ABIN1606294，抗体在线)，以及以1:200的比例稀释的二抗(Alexa 594，货号A21205，英杰公司)进行处理。进行DAPI染色。然后，将每个细胞系的样品置于载玻片上并使用共聚焦显微镜(Olympus，FV1000)观察。
结果，确定了蛋白A56在被溶瘤病毒感染的A549和HCT-116细胞系的细胞表面上表达(图2和3)。
实验例2.小鼠肿瘤组织表面蛋白A56表达的鉴定(I)
将制备例1.3中制备的含有编码蛋白A56或其片段的核酸的溶瘤病毒对癌症诱导小鼠模型进行腹膜内给药，以确定蛋白A56是否在组织表面上表达。
具体而言，将6.3×106个细胞的HT-29结直肠癌细胞系(韩国细胞系库，KCLB)皮下移植BALB/c裸鼠以诱导癌症。当平均肿瘤体积达到150mm3至200mm3时，将制备例1.3中制备的溶瘤病毒以2×107pfu的剂量对小鼠进行腹膜内给药。然后在第4天处死小鼠，从中收集肿瘤组织和脑、心、肺、肌肉、肾、肝和脾组织。
以与实验例1相同的方式进行蛋白A56的免疫荧光染色。进行DAPI染色。然后，将每个组织的样品放在载玻片上并使用荧光显微镜进行观察。
结果，确定了蛋白A56在经溶瘤病毒处理的小鼠的肿瘤组织表面上表达。另一方面，发现蛋白A56在脑、心脏、肺、肌肉、肾、肝和脾组织中不表达(图4)。从这些结果可以确定，在溶瘤病毒给药后产生靶向表达于肿瘤组织表面上的蛋白A56的抗体的情况下，该抗体可以用作抗癌免疫疗法。
实验例3.兔组织表面蛋白A56表达的鉴定
将制备例1.3中制备的含有编码蛋白A56或其片段的核酸的溶瘤病毒静脉内给予正常兔，以确定蛋白A56是否在组织表面表达。
具体地，以1×108pfu或1×109pfu的剂量给新西兰兔静脉内施用制备实施例1.3中产生的溶瘤病毒。然后，在第3周或第8周，处死兔子，从中收集脑、心、肺、肌肉、肾、肝和脾组织。
以与实验例1相同的方式进行蛋白A56的免疫荧光染色。进行DAPI染色。然后，将每个组织的样品放在载玻片上并使用荧光显微镜进行观察。
结果发现，在给予溶瘤病毒的兔的心脏、肺、肌肉、肾脏、肝脏和脾脏组织中没有表达蛋白A56。
另一方面，在给予溶瘤病毒的兔子的脑组织中检测到荧光反应。为鉴别检测到的荧光反应是否为抗A56抗体的非特异性反应，对未给予溶瘤病毒的正常家兔的脑组织按上述相同方法进行免疫荧光染色，然后使用荧光显微镜检查其中的荧光反应。
结果，即使在未给予溶瘤病毒的兔子的脑组织中，也检测到荧光反应。从该结果可以确定，这种荧光反应是非特异性反应(图5)。
另外，对于未给予溶瘤病毒的正常人的脑组织(韩国釜山国立大学梁山医院)，以与上述相同的方式进行免疫荧光染色，结果使用荧光显微镜检测出微弱的荧光反应。然而，基于抗体不穿过血脑屏障的观点来看，除非将抗体直接施用于脑室，否则可以确定抗A56抗体不会引起非特异性反应。
实验例4.小鼠肿瘤组织表面蛋白A56表达的鉴定(II)
将制备例1.3中制备的含有编码蛋白A56或其片段的核酸的溶瘤病毒和羟基脲共同给予癌症诱导小鼠模型，以确定蛋白A56是否在其组织表面上表达。
具体而言，将6.3×106个细胞的Renca癌细胞系(韩国细胞系库)皮下移植BALB/c裸鼠以诱导癌症。当平均肿瘤体积达到150mm3～200mm3时，将制备例1.3中制备的溶瘤病毒以2×107pfu的剂量对小鼠进行瘤内给药，并以30mg/kg的剂量给药羟基脲。
将制备的肾癌细胞移植小鼠分为三组(n＝4)。以生理盐水瘤内给药组为对照组，溶瘤病毒单独给药组(1×107pfu)和溶瘤病毒(1×107pfu)与羟基脲(30mg/kg)联合给药组为实验组。溶瘤病毒在第0天和第14天两次肿瘤内给药，羟基脲从溶瘤病毒给药前1天到溶瘤病毒给药后第21天，除了溶瘤病毒给药当天，每周腹腔给药6次。
在第一次给予溶瘤病毒后第7、10和14天处死小鼠，从中收集肿瘤组织。此外，在第二次给予溶瘤病毒后的第21、24和28天处死小鼠，从中收集肿瘤组织。以与实验例1相同的方式进行蛋白A56的免疫荧光染色。进行DAPI染色。然后，将每个组织的样品放在载玻片上并使用荧光显微镜进行观察。
结果发现，直到第一次施用溶瘤病毒后的7、10和14天，仅接受溶瘤病毒给药组和同时接受溶瘤病毒和羟基脲给药组的小鼠的肿瘤表面清楚地表达了蛋白A56(图6和7)。
另外，确认了在第一次给予溶瘤病毒后第14天进行第二次溶瘤病毒给药的情况下，直至第二次给药后的第7、10和14天，蛋白A56在肿瘤表面表达(图8和9)。特别地，发现在第24天(D10)蛋白A56在死细胞和活细胞中均有表达。
此外，发现与只接受生理盐水的给药组的小鼠相比，单独给予溶瘤病毒的组的小鼠和同时给予溶瘤病毒和羟基脲的组的小鼠的肿瘤体积显著减小(图10)。此外，在第3、7、14、18和21天测量三组小鼠的体重。结果在所有组中均未观察到显著的体重减轻(图11)。
实验例5.蛋白A56或其片段在细胞表面的表达
将制备例1.3中制备的含有编码蛋白A56或其片段的核酸的溶瘤病毒用于处理A549癌细胞系，以鉴定蛋白A56是否在细胞表面表达。
具体地，将A549(肺癌，ATCC，美国)细胞系以每孔3.5×104个细胞接种在12孔板中的盖玻片上。随后，用溶瘤病毒以0.1的MOI感染细胞，然后在37℃和5％CO2的条件下孵育30小时。收获每个孵育的细胞系。然后，用4％(v/v)多聚甲醛(PFA)、1％(v/v)BSA、以1:500的比例稀释的抗A56抗体(货号ABIN1606294，抗体在线)、和以1:200的比例稀释的二抗(Alexa594，货号A21205，英杰公司)进行处理。细胞核用DAPI染色，高尔基体用荧光染料染色。此后，将细胞系样品置于载玻片上并使用共聚焦显微镜(Olympus，FV1000)观察。结果示于图12和13中，以及表2中。
[表2]
野生型A56(A56-G)和通过部分截短A56的六个区域获得的A56片段被允许在细胞表面上表达。结果确认了仅野生型A56(A56-G)和IgV样结构域被截短的A56-121到达细胞表面并在其上表达。已确定在排除了IgV样结构域的A56变体中，信号肽、跨膜结构域、茎区和串联重复区被单独或组合截短的变体不在质膜上表达。另外，发现在包含IgV样结构域的情况下，即使是仅包含跨膜结构域的变体也不在质膜上表达。即确定了排除IgV样结构域并且包括五个区域的变体在质膜上表达。
II.产生结合蛋白A56或其片段的抗体
制备例2.蛋白A56及其片段的制备
制备引物以从野生型蛋白A56中去除特定区域，并通过形成与GFP重叠的区域进行重叠PCR。
具体而言，将载体DNA(N293F-A56-C-HIS)扩增，导入HEK293F细胞，在其中过表达。随后，通过亲和色谱法(Ni-NTA)进行初次纯化，然后通过阳离子交换色谱法(CEX)进行二次纯化。这样，最终产生了A56-C-HIS蛋白(图97和98)。
制备例3.结合蛋白A56或其片段的抗体的制备(I)
像Ybiologics提出了制备抗A56抗体的申请，所述抗体与A56蛋白或其变体或片段特异性结合。使用噬菌体文库技术产生了61种抗体并分析了其CDR。将噬菌体文库添加到包被有A56抗原的试管中，并进行生物淘选以发现结合命中(binding hits)。通过平均洗涤3次来选择具有特异性结合的噬菌体。执行了三个筛选过程。然后，进行亲和力测试，并挑选少量显示高亲和力的菌落，以确定菌落是否与实际抗原表现出亲和力。选择命中数相对较高的集合，并使用自动化系统进行挑选和命中选择。
测量由此产生的每种抗A56抗体与蛋白A56之间的亲和力。结果示于图14至19中。此外，各抗A56抗体的产率如图20A至20C所示。此外，图21至37显示了通过SDS-PAGE鉴定每种产生的抗A56抗体获得的结果。
实验例6.抗A56抗体的亲和力测定
免疫管的每个孔都涂有蛋白A56，然后进行封闭过程。在封闭过程之后，使每个孔与从100nM开始进行了三倍连续稀释的抗体反应，，在室温下反应预定时间。之后，用PBS清洗3次后，在室温下也用第二抗体处理预定时间。随后，在各个浓度下测量每种抗A56抗体和蛋白A56之间的亲和力。
实验例7.肿瘤细胞表面表达的蛋白A56与抗A56抗体结合的鉴定(I)
用制备例1.3中制备的溶瘤病毒以1的MOI分别感染HeLa、HT-29、A549、MCF-7和PC-3细胞系。24小时后，每个感染溶瘤病毒的细胞系分别用制备例3中制备的5种抗A56抗体(ab01、ab02、ab03、ab04、ab05)处理，然后使反应在4℃进行1小时。然后，用PBS洗涤3次，然后用抗-hIgG抗体(FITC，艾博抗)进行处理。随后，使反应在4℃的温度下进行1小时。1小时后，使用PI染色试剂盒(BD Annexin V试剂盒)根据制造商的手册进行染色，然后用流式细胞仪(Moflo Astrios EQ，贝克曼库尔特)进行分析。
如图38和39所示，与未用溶瘤病毒处理的癌细胞系(仅细胞)的分析结果(蓝色区域)比较表明，用溶瘤病毒处理的癌细胞系(细胞+VV)结合了抗A56抗体，从而导致向红色区域移动。从这些结果可以确定抗A56抗体与肿瘤细胞表面上表达的蛋白A56结合。
制备例4.结合蛋白A56或其片段的抗体的制备(II)
此外，向LakePharma提出了基于抗A56抗体(货号ABIN1606294，抗体在线)生产抗体的申请，通过逆向编码工程生产抗体。将由此产生的两种抗体命名为“LakePharma变体3”和“LakePharma变体4”。
实验例8.肿瘤细胞表面表达的蛋白A56与抗A56抗体结合的鉴定(II)
用制备例1.3中产生的溶瘤病毒以1的MOI感染HeLa细胞系。24小时后，将感染溶瘤病毒的HeLa细胞系分别用抗A56抗体(货号ABIN1606294，抗体在线)和制备例4中制备的两种抗A56抗体(LakePharma变体3、4)，然后在4℃反应1小时。然后，用PBS洗涤3次，然后用抗-hIgG抗体(FITC，艾博抗)进行处理。随后，使反应在4℃的温度下进行1小时。1小时后，使用PI染色试剂盒(BD Annexin V试剂盒)根据制造商的手册进行染色，然后用流式细胞仪(Moflo Astrios EQ，贝克曼库尔特)进行分析。
结果发现，在用抗A56抗体(货号ABIN1606294，抗体在线)作为阳性对照(细胞+OV)进行处理的情况下，抗A56抗体结合至由于用溶瘤病毒处理而在HeLa细胞系的细胞表面上表达的A56，从而导致与仅用HeLa细胞系进行处理的情况(仅细胞)相比向右移动(图40)。
此外，实验组(细胞+OV)在分别用两种抗A56抗体(LakePharma变体3、4)进行处理的情况下，所述抗A56抗体与由于溶瘤病毒处理而表达于HeLa细胞系细胞表面的A56结合，从而导致与仅使用HeLa细胞系进行处理的情况(仅细胞)相比向右移动(图41和42)。从这些结果可以确定，制备例4中产生的两种抗A56抗体(LakePharma变体3、4)与细胞表面上表达的A56特异性结合(图43)。
实验例9.肿瘤细胞表面表达的蛋白A56与抗A56抗体结合的鉴定：A549癌细胞系(I)
A549癌细胞系用溶瘤病毒(OTS-412或WOTS-418)处理，所述病毒编码SEQ ID NO:1074或1078的蛋白A56并在制备例1.3中制备，使得蛋白A56在该细胞系中表达。然后，鉴定抗A56抗体(十种抗人A56抗体和两种抗鼠A56抗体)是否与蛋白A56结合。
A549癌细胞系用MOI为1的各种溶瘤病毒处理。24小时后，用制备例3中制备并使用人scFv作为结合结构域的十种抗体(结合亲和力前10，即Ab18、Ab19、Ab01、Ab13、Ab14、Ab08、Ab03、Ab51、Ab55、Ab16)和制备例4中制备的两种抗体(LP变体03和LP变体04)进行处理。1小时后，添加二抗(山羊抗人IgG FC、山羊抗小鼠IgG H&L)。1小时后，进行洗涤，A549癌细胞系用碘化丙啶(PI)染色并用流式细胞仪分析。
结果发现，对于溶瘤病毒处理的A549癌细胞系，10种人抗体和2种小鼠抗体显示出90％或更高相似的结合信号(图44至55)。此外，在溶瘤病毒处理的A549癌细胞系中观察到的峰值方面，确定了10种人抗体之间存在轻微差异，并且差异不显著(图56和57)。
实验例10.肿瘤细胞表面表达的蛋白A56与抗A56抗体结合的鉴定：A549癌细胞系(II)
A549癌细胞系用溶瘤病毒(OTS-412或WOTS-418)处理，所述病毒编码SEQ ID NO:1074或1078的蛋白A56并在制备例1.3中制备，使得蛋白A56在细胞系中表达。然后，鉴定制备例3和4中制备的抗A56抗体(Ybiologics：Ab18和Ab16，LakePharma：LakePharma变体3、4)是否与蛋白A56结合。
以与实验例9相同的方式用溶瘤病毒和抗A56抗体处理A549癌细胞系。用碘化丙啶(PI)对A549癌细胞系进行染色，并用流式细胞仪(Moflo Astrios EQ，贝克曼库尔特)进行分析。
结果确定了Ybiologics和LakePharma各自生产的抗A56抗体对于溶瘤病毒处理的A549癌细胞系表现出93％或更高相似的结合信号(图58至61)。
实验例11.肿瘤细胞表面表达的蛋白A56与抗A56抗体结合的鉴定：PC3癌细胞系(I)
PC3癌细胞系用溶瘤病毒(OTS-412或WOTS-418)处理，所述病毒编码SEQ ID NO：1074或1078的蛋白A56并在制备例1.3中制备，使蛋白A56在细胞系中表达。然后，鉴定抗A56抗体(10种人抗A56抗体和2种小鼠抗A56抗体)是否与A56蛋白结合。
以与实验例9相同的方式，用各种溶瘤病毒，以及在制备例3中制备并使用人scFv作为结合域的10种抗体(结合亲和力前10，即Ab18、Ab19、Ab01、Ab13、Ab14、Ab08、Ab03、Ab51、Ab55、Ab16)，以及制备例4中制备的两种抗体(LP变体03和LP变体04)处理PC3癌细胞系。PC3癌细胞系用PI染色，用流式细胞仪(Moflo Astrios EQ，贝克曼库尔特)进行分析。
结果发现，对于溶瘤病毒处理的PC3癌细胞系，10种人抗体和2种小鼠抗体表现出90％或更高相似的结合信号(图62至73)。此外，在溶瘤病毒处理的PC3癌细胞系中观察到的峰值方面，10种人抗体之间存在细微差异，信号为60％或更高，其中抗A56抗体Ab51分别表现出70.71％和78.61％的最高结合信号(图74和75)。
实验例12.肿瘤细胞表面表达的蛋白A56与抗A56抗体结合的鉴定：PC3癌细胞系(II)
PC3癌细胞系用溶瘤病毒(OTS-412或WOTS-418)处理，所述病毒编码SEQ ID NO:1074或1078的蛋白A56并在制备例1中制备，使得蛋白A56在细胞系中表达。然后，鉴定制备例3和4中制备的抗A56抗体(Ybiologics：Ab18和Ab16，LakePharma：LakePharma变体3、4)是否与蛋白A56结合。
以与实验例9相同的方式用溶瘤病毒和抗A56抗体处理PC3癌细胞系。用PI染色PC3癌细胞系，并用流式细胞仪(Moflo Astrios EQ，贝克曼库尔特)进行分析。
结果确定了由Ybiologics生产的各个抗A56抗体(Ab18和Ab16)对于溶瘤病毒处理的PC3癌细胞系分别显示出60％或更高和70％或更高的结合信号(图76和77)。此外，已确定由LakePharma生产的各个抗A56抗体(LakePharma变体3、4)均显示出90％或更高的结合信号(图78和79)。
实验例13.肿瘤细胞表面表达的蛋白A56与抗A56抗体结合的鉴定：MCF7癌细胞系(I)
MCF7癌细胞系用溶瘤病毒(OTS-412或WOTS-418)处理，所述病毒编码SEQ ID NO:1074或1078的蛋白A56并在制备例1中制备，使得蛋白A56在细胞系中表达。然后，鉴定抗A56抗体(10种人抗A56抗体和2种小鼠抗A56抗体)是否与A56蛋白结合。
以与实验例9相同的方式，用各种溶瘤病毒，以及在制备例3中制备并使用人scFv作为结合结构域的十种抗体(结合亲和力前10，即Ab18、Ab19、Ab01、Ab13、Ab14、Ab08、Ab03、Ab51、Ab55、Ab16)，以及制备例4中制备的两种抗体(LP变体03和LP变体04)处理MCF7癌细胞系。用PI对MCF7癌细胞系进行染色，用流式细胞仪(Moflo Astrios EQ，贝克曼库尔特)进行分析。
结果发现，对于溶瘤病毒处理的MCF7癌细胞系，10种人抗体和2种小鼠抗体显示出80％或更高相似的结合信号(图80至91)。此外，确认了尽管10种人抗体在溶瘤病毒处理的MCF7癌细胞系中观察到的峰值方面有轻微差异，但信号为80％或更高(图92和93)。
实验例14.肿瘤细胞表面表达的蛋白A56与抗A56抗体结合的鉴定：MCF7癌细胞系(II)
MCF7癌细胞系用溶瘤病毒(OTS-412或WOTS-418)处理，所述病毒编码SEQ ID NO:1074或1078的蛋白A56并在制备例1中制备，使得蛋白A56在细胞系中表达。然后，鉴定制备例4中制备的抗A56抗体(LakePharma：LakePharma变体3、4)是否与蛋白A56结合。
以与实验例9相同的方式用溶瘤病毒和抗A56抗体处理MCF7癌细胞系。用PI染色MCF7癌细胞系，并用流式细胞仪(Moflo Astrios EQ，贝克曼库尔特)进行分析。
结果确定了由LakePharma生产的各个抗A56抗体(LakePharma变体3、4)对于溶瘤病毒处理的MCF7癌细胞系均表现出97％或更高的结合信号(图94和95)。
III.使用溶瘤病毒和抗体鉴定抗癌效果
实验例15.使用溶瘤病毒和抗体鉴定抗癌效果
将制备例1.3中制备的溶瘤病毒施用于以与实验例2中相同的方式制备的癌症诱发小鼠。经过预定时间后，作为对照组的癌症诱发小鼠接受生理盐水的处理，作为实验组的癌症诱发小鼠接受制备例3中产生的抗体的处理。结果发现，未被溶瘤病毒杀死的癌细胞留存在对照组的肿瘤组织中，而在实验组的肿瘤组织中的癌细胞被完全杀死。
实验例16.使用溶瘤病毒和免疫细胞鉴定抗癌效果
将制备例1.3中制备的溶瘤病毒施用于以与实验例2中相同的方式制备的癌症诱发小鼠。经过预定时间后，作为对照组的癌症诱发小鼠接受生理盐水的处理，作为实验组的癌症诱发小鼠接受制备的免疫细胞的处理。结果发现，未被溶瘤病毒杀死的癌细胞留存在对照组的肿瘤组织中，而在实验组的肿瘤组织中的癌细胞被完全杀死。
<110> 拜耳诺克斯有限公司
<120> 肿瘤靶向蛋白或其片段、与其结合的抗体及其用途
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<210> 13
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A02的H-FR4
<400> 13
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 14
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A02的L-FR1
<400> 14
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser
20 25
<210> 15
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A02的L-FR2
<400> 15
Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
1 5 10 15
Tyr
<210> 16
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A02的L-FR3
<400> 16
Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 17
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A02的L-FR4
<400> 17
Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
1 5 10
<210> 18
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的H-CDR1
<400> 18
Gly Tyr Thr Phe Thr Pro Tyr Tyr
1 5
<210> 19
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的H-CDR2
<400> 19
Ile Ile Pro Leu Leu Gly Lys Ala
1 5
<210> 20
<211> 14
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的H-CDR3
<400> 20
Ala Arg Glu Ala Arg Gly Val Asn Tyr Tyr Gly Met Asp Val
1 5 10
<210> 21
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的L-CDR1
<400> 21
Gln Gly Ile Ser His Ser
1 5
<210> 22
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03 的L-CDR2
<400> 22
Val Ala Ser
1
<210> 23
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的L-CDR3
<400> 23
Gln Gln Thr Asn Asn Phe Pro Tyr Thr
1 5
<210> 24
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的SCFV
<400> 24
caggtgcagc tggtgcagtc tggggctgag gttaggaagc ctggggcctc cgtgaagatt 60
tcctgcatgg catctggata caccttcacc ccctactata tccactgggt gcggcaggcc 120
cctggccaag ggcttgagtg gatgggaggg atcatccctc tccttggtaa agcgacctac 180
gcacagaagt tccagggcag aatcacggtt accgcggacg aatccacgag cacagcctac 240
atggaactga gcagt 255
<210> 25
<211> 121
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的VH2
<400> 25
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Met Ala Ser Gly Tyr Thr Phe Thr Pro Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Leu Leu Gly Lys Ala Thr Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Ile Thr Val Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Ala Arg Gly Val Asn Tyr Tyr Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 26
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的VL2
<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser His Ser
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Asp Val Ala Ser Arg Leu Gln Ser Gly Val Pro Leu Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro
65 70 75 80
Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Asn Phe Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 27
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的H-FR1
<400> 27
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Met Ala Ser
20 25
<210> 28
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的H-FR2
<400> 28
Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Gly
<210> 29
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的H-FR3
<400> 29
Thr Tyr Ala Gln Lys Phe Gln Gly Arg Ile Thr Val Thr Ala Asp Glu
1 5 10 15
Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 30
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的H-FR4
<400> 30
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 31
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的L-FR1
<400> 31
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser
20 25
<210> 32
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的L-FR2
<400> 32
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
1 5 10 15
Asp
<210> 33
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的L-FR3
<400> 33
Ile Asp Val Ala Ser Arg Leu Gln Ser Gly Val Pro Leu Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln
20 25 30
Pro Glu Asp Ser
35
<210> 34
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A03的L-FR4
<400> 34
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
1 5 10
<210> 35
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的H-CDR1
<400> 35
Gly Gly Thr Phe Ser Tyr Arg Tyr
1 5
<210> 36
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的H-CDR2
<400> 36
Ile Thr Pro Phe Asn Gly Tyr Thr
1 5
<210> 37
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的H-CDR3
<400> 37
Val Thr Gly Leu Gly Lys Thr Asn Leu Asp Ser
1 5 10
<210> 38
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04 的L-CDR1
<400> 38
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 39
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的L-CDR2
<400> 39
Gln Ile Ser
1
<210> 40
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的L-CDR3
<400> 40
Met Gln Leu Thr Gln Phe Pro Leu Thr
1 5
<210> 41
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的SCFV
<400> 41
caggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60
tcctgcaagg cttctggagg caccttcagt taccgctacc tgcactgggt gcgacaggcc 120
tccggacagg cgcttgagtg gatggggtgg atcacacctt tcaatggtta caccaactac 180
gcacagaaat tccaggacag agtcaccatt accagggaca ggtctatgag cacagcctac 240
atggagctga gcagc 255
<210> 42
<211> 118
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的VH2
<400> 42
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Tyr Arg
20 25 30
Tyr Leu His Trp Val Arg Gln Ala Ser Gly Gln Ala Leu Glu Trp Met
35 40 45
Gly Trp Ile Thr Pro Phe Asn Gly Tyr Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Arg Asp Arg Ser Met Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Thr Gly Leu Gly Lys Thr Asn Leu Asp Ser Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 43
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的VL2
<400> 43
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro
35 40 45
Pro Arg Leu Leu Ile Tyr Gln Ile Ser Lys Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Leu
85 90 95
Thr Gln Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 44
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的H-FR1
<400> 44
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 45
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的H-FR2
<400> 45
Leu His Trp Val Arg Gln Ala Ser Gly Gln Ala Leu Glu Trp Met Gly
1 5 10 15
Trp
<210> 46
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的H-FR3
<400> 46
Asn Tyr Ala Gln Lys Phe Gln Asp Arg Val Thr Ile Thr Arg Asp Arg
1 5 10 15
Ser Met Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 47
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的H-FR4
<400> 47
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 48
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的L-FR1
<400> 48
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser
20 25
<210> 49
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的L-FR2
<400> 49
Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro Pro Arg Leu Leu Ile
1 5 10 15
Tyr
<210> 50
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的L-FR3
<400> 50
Ile Tyr Gln Ile Ser Lys Arg Phe Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 51
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A04的L-FR4
<400> 51
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 52
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的H-CDR1
<400> 52
Gly Asp Thr Leu Thr Tyr Arg Phe
1 5
<210> 53
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的H-CDR2
<400> 53
Ile Thr Pro Phe Asn Gly Asn Thr
1 5
<210> 54
<211> 13
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05 的H-CDR3
<400> 54
Ala Thr Gly Gly Gly Asn Asn Tyr Tyr Gly Met Glu Val
1 5 10
<210> 55
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的L-CDR1
<400> 55
Gln Gly Ile Gly Ser Trp
1 5
<210> 56
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的L-CDR2
<400> 56
Gly Ala Ser
1
<210> 57
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的L-CDR3
<400> 57
Gln Lys Ala Asn Asn Phe Pro Tyr Thr
1 5
<210> 58
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的SCFV
<400> 58
caggtgcagc tggtacagtc tggggctgag gtgaagaaga ctgggtcctc agtgaaggtt 60
tcgtgcaagg cttccggaga cacccttacc taccgcttcc tgcactgggt gcgacaggcc 120
cccggacaag cgcctgagtg gattggatgg atcacacctt tcaatggtaa caccaactac 180
gcacagaaat tccaggacag agtcaccatt accagggaca ggtctatgag cacagcctac 240
atggagctga gcagc 255
<210> 59
<211> 120
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的VH2
<400> 59
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Thr Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Leu Thr Tyr Arg
20 25 30
Phe Leu His Trp Val Arg Gln Ala Pro Gly Gln Ala Pro Glu Trp Ile
35 40 45
Gly Trp Ile Thr Pro Phe Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Arg Asp Arg Ser Met Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Gly Gly Gly Asn Asn Tyr Tyr Gly Met Glu Val Trp Gly Gln
100 105 110
Gly Thr Pro Ile Thr Val Ser Ser
115 120
<210> 60
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的VL2
<400> 60
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Asn Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Gly Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Lys Ala Asn Asn Phe Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys
100 105
<210> 61
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的H-FR1
<400> 61
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Thr Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 62
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的H-FR2
<400> 62
Leu His Trp Val Arg Gln Ala Pro Gly Gln Ala Pro Glu Trp Ile Gly
1 5 10 15
Trp
<210> 63
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的H-FR3
<400> 63
Asn Tyr Ala Gln Lys Phe Gln Asp Arg Val Thr Ile Thr Arg Asp Arg
1 5 10 15
Ser Met Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 64
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的H-FR4
<400> 64
Trp Gly Gln Gly Thr Pro Ile Thr Val Ser Ser
1 5 10
<210> 65
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的L-FR1
<400> 65
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 66
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的L-FR2
<400> 66
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Asn Leu Leu Ile
1 5 10 15
Tyr
<210> 67
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的L-FR3
<400> 67
Ile Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Gly Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln
20 25 30
Pro Glu Asp Phe
35
<210> 68
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01A05的L-FR4
<400> 68
Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys
1 5 10
<210> 69
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的H-CDR1
<400> 69
Gly Phe Thr Ile Ser Asn Tyr Ala
1 5
<210> 70
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的H-CDR2
<400> 70
Val Ser Gly Ser Gly Val Thr Thr
1 5
<210> 71
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的H-CDR3
<400> 71
Val Arg Met Thr Gly Gly Pro Leu
1 5
<210> 72
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的L-CDR1
<400> 72
Gln Gly Val Arg Asn Asp
1 5
<210> 73
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的L-CDR2
<400> 73
Gly Ala Ser
1
<210> 74
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的L-CDR3
<400> 74
Leu Gln Asp Phe Ile Tyr Pro Tyr Thr
1 5
<210> 75
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的SCFV
<400> 75
cagatgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60
tcctgtacag cctctggatt caccattagc aactacgcca tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtcgcaact gttagtggta gtggtgttac cacacactac 180
gcagcctccg tgaaggaccg gttcaccgtc tccagtgaca gttccaagaa cacacttttt 240
ctgcaaatga acagt 255
<210> 76
<211> 115
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的VH2
<400> 76
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Asn Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Thr Val Ser Gly Ser Gly Val Thr Thr His Tyr Ala Ala Ser Val
50 55 60
Lys Asp Arg Phe Thr Val Ser Ser Asp Ser Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Met Thr Gly Gly Pro Leu Trp Gly Gln Gly Thr Leu Ile Thr
100 105 110
Val Ser Ser
115
<210> 77
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的VL2
<400> 77
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Arg Asn Asp
20 25 30
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Phe Ile Tyr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 78
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的H-FR1
<400> 78
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser
20 25
<210> 79
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的H-FR2
<400> 79
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
1 5 10 15
Thr
<210> 80
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的H-FR3
<400> 80
His Tyr Ala Ala Ser Val Lys Asp Arg Phe Thr Val Ser Ser Asp Ser
1 5 10 15
Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 81
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的H-FR4
<400> 81
Trp Gly Gln Gly Thr Leu Ile Thr Val Ser Ser
1 5 10
<210> 82
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的L-FR1
<400> 82
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 83
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的L-FR2
<400> 83
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 84
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的L-FR3
<400> 84
Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
20 25 30
Pro Glu Asp Phe
35
<210> 85
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01B01的L-FR4
<400> 85
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
1 5 10
<210> 86
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的H-CDR1
<400> 86
Gly Phe Thr Phe Ser Asn Asn Trp
1 5
<210> 87
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的H-CDR2
<400> 87
Ile Asn Arg Asp Gly Ser Glu Arg
1 5
<210> 88
<211> 21
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的H-CDR3
<400> 88
Val Arg Asp Ser Leu Ile Ile Tyr Asp Asn Ser Trp Tyr Pro Tyr Tyr
1 5 10 15
His Gly Met Ala Val
20
<210> 89
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的L-CDR1
<400> 89
Ser Leu Arg Lys Tyr His
1 5
<210> 90
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的L-CDR2
<400> 90
Gly Lys Asn
1
<210> 91
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的L-CDR3
<400> 91
Asn Ser Arg Asp Ser Ser Pro Asn His Leu Val
1 5 10
<210> 92
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的SCFV
<400> 92
caggtgcagc tggtagagtc tgggggacgg ttggtccagc ctgggggatc cctgagactc 60
tcctgcgtaa cttctggatt cacttttagt aacaattgga tgacttgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtggccacc ataaaccgag atggaagtga gaggtattat 180
gtggactctg tgaaggaccg gttcaccatc tccagagaaa acagcaaaaa ctccctgtat 240
ctgcaaatga acagt 255
<210> 93
<211> 128
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的VH2
<400> 93
Gln Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Ser Asn Asn
20 25 30
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Thr Ile Asn Arg Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val
50 55 60
Lys Asp Arg Phe Thr Ile Ser Arg Glu Asn Ser Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Asp Ser Leu Ile Ile Tyr Asp Asn Ser Trp Tyr Pro Tyr Tyr
100 105 110
His Gly Met Ala Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 94
<211> 108
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的VL2
<400> 94
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Lys Tyr His Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Gly Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Glu Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Pro Asn His
85 90 95
Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 95
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的H-FR1
<400> 95
Gln Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Thr Ser
20 25
<210> 96
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的H-FR2
<400> 96
Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
1 5 10 15
Thr
<210> 97
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的H-FR3
<400> 97
Tyr Tyr Val Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Glu Asn
1 5 10 15
Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 98
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的H-FR4
<400> 98
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 99
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的L-FR1
<400> 99
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp
20 25
<210> 100
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的L-FR2
<400> 100
Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile
1 5 10 15
Tyr
<210> 101
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的L-FR3
<400> 101
Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Gly Arg Phe Ser
1 5 10 15
Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Glu Ala Gln
20 25 30
Ala Glu Asp Glu
35
<210> 102
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C08的L-FR4
<400> 102
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
1 5 10
<210> 103
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的H-CDR1
<400> 103
Gly Phe Arg Ser Ser Thr Phe Trp
1 5
<210> 104
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的H-CDR2
<400> 104
Ile Lys Gln Asp Gly Ser Glu Ile
1 5
<210> 105
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的H-CDR3
<400> 105
Ala Arg Thr Arg Gly Ala Thr Ile Tyr Asp His Tyr Tyr Gly Met Asp
1 5 10 15
Val
<210> 106
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的L-CDR1
<400> 106
Ser Ser Asn Ile Gly Ser Tyr Ser
1 5
<210> 107
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的L-CDR2
<400> 107
Gly His Asn
1
<210> 108
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的L-CDR3
<400> 108
Ala Ala Trp Asp Asp Ser Val Asp Gly Trp Val
1 5 10
<210> 109
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的SCFV
<400> 109
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60
tcctgtgtag cctctggatt caggtctagt actttttgga tgagttggat ccgccaggct 120
ccagggaagg ggctggagtg ggtggcccac ataaagcaag atggaagtga gatatactat 180
gtggactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa ctccctgtat 240
ctgcaaatga acagt 255
<210> 110
<211> 124
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的VH2
<400> 110
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Arg Ser Ser Thr Phe
20 25 30
Trp Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala His Ile Lys Gln Asp Gly Ser Glu Ile Tyr Tyr Val Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Thr Arg Gly Ala Thr Ile Tyr Asp His Tyr Tyr Gly Met Asp
100 105 110
Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser
115 120
<210> 111
<211> 110
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的VL2
<400> 111
Gln Ser Ala Leu Thr Gln Pro Pro Ser Arg Ser Val Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Tyr
20 25 30
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Gly His Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65 70 75 80
Ser Ala Asp Glu Gly Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Val
85 90 95
Asp Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 112
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的H-FR1
<400> 112
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser
20 25
<210> 113
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的H-FR2
<400> 113
Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
1 5 10 15
His
<210> 114
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的H-FR3
<400> 114
Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 115
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的H-FR4
<400> 115
Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser
1 5 10
<210> 116
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的L-FR1
<400> 116
Gln Ser Ala Leu Thr Gln Pro Pro Ser Arg Ser Val Thr Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Ser Gly Ser
20 25
<210> 117
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的L-FR2
<400> 117
Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 118
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的L-FR3
<400> 118
Ile Tyr Gly His Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
20 25 30
Ser Ala Asp Glu
35
<210> 119
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01C12的L-FR4
<400> 119
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
1 5 10
<210> 120
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的H-CDR1
<400> 120
Gly Gly Ser Phe Ser Thr Tyr Ala
1 5
<210> 121
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的H-CDR2
<400> 121
Ile Ile Pro Ile Ser Asp Ile Arg
1 5
<210> 122
<211> 13
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的H-CDR3
<400> 122
Ala Lys Gly Gly Arg Leu Leu Ser Thr His Phe Asp Tyr
1 5 10
<210> 123
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的L-CDR1
<400> 123
Ser Ser Asn Ile Gly Asn Asn Tyr
1 5
<210> 124
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的L-CDR2
<400> 124
Asp Asp Asp
1
<210> 125
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的L-CDR3
<400> 125
Gly Thr Trp His Ser Gly Leu Ser Ala Gly Val Val
1 5 10
<210> 126
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的SCFV
<400> 126
caggtgcagc tggtggagtc tgggggtgag gtgaagaagc ctgggtcctc ggtgaaggtc 60
tcctgcaagg cttctggagg cagcttcagc acctatgcta tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaagg atcatcccca tctctgatat cagaaactac 180
gcacagaaat tccagggcag agtcacgtta accgcggaca gagccacgag cacagcctac 240
atggagctga gcagc 255
<210> 127
<211> 120
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的VH2
<400> 127
Gln Val Gln Leu Val Glu Ser Gly Gly Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Thr Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Ser Asp Ile Arg Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Leu Thr Ala Asp Arg Ala Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Arg Leu Leu Ser Thr His Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 128
<211> 111
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的VL2
<400> 128
Gln Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
20 25 30
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
35 40 45
Ile Tyr Asp Asp Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65 70 75 80
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp His Ser Gly Leu
85 90 95
Ser Ala Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 129
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的H-FR1
<400> 129
Gln Val Gln Leu Val Glu Ser Gly Gly Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 130
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的H-FR2
<400> 130
Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Arg
<210> 131
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的H-FR3
<400> 131
Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Ala Asp Arg
1 5 10 15
Ala Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 132
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的H-FR4
<400> 132
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 133
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的L-FR1
<400> 133
Gln Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
1 5 10 15
Lys Val Thr Ile Ser Cys Ser Gly Ser
20 25
<210> 134
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的L-FR2
<400> 134
Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 135
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的L-FR3
<400> 135
Ile Tyr Asp Asp Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
20 25 30
Thr Gly Asp Glu
35
<210> 136
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01F12的L-FR4
<400> 136
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
1 5 10
<210> 137
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的H-CDR1
<400> 137
Gly Gly Thr Leu Ser Ser Tyr Pro
1 5
<210> 138
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的H-CDR2
<400> 138
Ile Ile Pro Ile Val Gly Arg Ala
1 5
<210> 139
<211> 15
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的H-CDR3
<400> 139
Ala Arg Glu Asn Pro Ser Ser Tyr Ala Pro Phe Ala Leu Asp Ile
1 5 10 15
<210> 140
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的L-CDR1
<400> 140
Ser Ser Asp Val Gly Gly Tyr Asn Tyr
1 5
<210> 141
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的L-CDR2
<400> 141
Asp Val Thr
1
<210> 142
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的L-CDR3
<400> 142
Ser Ser Tyr Ser Ser Ser Thr Phe Tyr Val
1 5 10
<210> 143
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的SCFV
<400> 143
caggtgcagc tggtacagtc tggggctgaa gtgaagaagc ctgggtcctc ggtgaaggtc 60
tcgtgcaagg cttctggagg caccctcagc agctatccca tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaagg atcattccta ttgttggtag agcaaactac 180
gcacagaagt tccagggcag agtcacgatt aacgcggaca catccacgaa cacagtccac 240
atggagttga gtagc 255
<210> 144
<211> 122
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的VH2
<400> 144
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Ser Tyr
20 25 30
Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Val Gly Arg Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Asn Ala Asp Thr Ser Thr Asn Thr Val His
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Asn Pro Ser Ser Tyr Ala Pro Phe Ala Leu Asp Ile Trp
100 105 110
Gly Gln Gly Thr Ala Val Thr Val Ser Ser
115 120
<210> 145
<211> 110
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的VL2
<400> 145
Asn Phe Met Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Gln Gly Lys Ala Pro Gln Leu
35 40 45
Ile Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ser Ser Ser
85 90 95
Thr Phe Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 146
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的H-FR1
<400> 146
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 147
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的H-FR2
<400> 147
Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Arg
<210> 148
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的H-FR3
<400> 148
Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Asn Ala Asp Thr
1 5 10 15
Ser Thr Asn Thr Val His Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 149
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的H-FR4
<400> 149
Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser
1 5 10
<210> 150
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的L-FR1
<400> 150
Asn Phe Met Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Ser
20 25
<210> 151
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的L-FR2
<400> 151
Val Ser Trp Tyr Gln Gln His Gln Gly Lys Ala Pro Gln Leu Ile Ile
1 5 10 15
Tyr
<210> 152
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的L-FR3
<400> 152
Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser
1 5 10 15
Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln
20 25 30
Ala Glu Asp Glu
35
<210> 153
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G06的L-FR4
<400> 153
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 154
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的H-CDR1
<400> 154
Gly Phe Asn Phe Asp Asp His Ala
1 5
<210> 155
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的H-CDR2
<400> 155
Ile Ser Trp Asn Gly Arg Ser Ile
1 5
<210> 156
<211> 18
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的H-CDR3
<400> 156
Ala Arg Asp Leu Ala His Ala Ser Gly Ser Leu Arg Arg Pro Phe Phe
1 5 10 15
Asp Tyr
<210> 157
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的L-CDR1
<400> 157
Gln Asp Ile Ser Thr Tyr
1 5
<210> 158
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的L-CDR2
<400> 158
Ser Thr Ser
1
<210> 159
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的L-CDR3
<400> 159
Gln Gln Leu Lys Ser Tyr Pro Arg Phe Thr
1 5 10
<210> 160
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的SCFV
<400> 160
caggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc 60
tcctgtgcag cctccggatt caactttgat gatcatgcca tgcactgggt ccggcaagct 120
ccagggaagg gcctggagtg ggtctccggt attagttgga atggacgtag catatactat 180
gcggactctg tgaggggccg attcaccatc tccagagaca acgccaggaa ctccctgcat 240
ctgcaaatga acagt 255
<210> 161
<211> 125
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的VH2
<400> 161
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asp Asp His
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Trp Asn Gly Arg Ser Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu His
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Ala His Ala Ser Gly Ser Leu Arg Arg Pro Phe Phe
100 105 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120 125
<210> 162
<211> 108
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的VL2
<400> 162
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Thr Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Ser Thr Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asn Phe Thr Leu Thr Ile Asn Asn Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Lys Ser Tyr Pro Arg
85 90 95
Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 163
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的H-FR1
<400> 163
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 164
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的H-FR2
<400> 164
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
1 5 10 15
Gly
<210> 165
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的H-FR3
<400> 165
Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ala Arg Asn Ser Leu His Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 166
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的H-FR4
<400> 166
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 167
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的L-FR1
<400> 167
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 168
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的L-FR2
<400> 168
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 169
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的L-FR3
<400> 169
Ile Tyr Ser Thr Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Thr Ile Asn Asn Leu Gln
20 25 30
Pro Glu Asp Phe
35
<210> 170
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01G11的L-FR4
<400> 170
Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
1 5 10
<210> 171
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的H-CDR1
<400> 171
Gly Phe Lys Phe Glu Asp His Ala
1 5
<210> 172
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的H-CDR2
<400> 172
Ile Ser Gly Asn Gly Asp Asp Thr
1 5
<210> 173
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的H-CDR3
<400> 173
Ala Arg Asp Arg Gly Pro Gly
1 5
<210> 174
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的L-CDR1
<400> 174
Gln Ser Val Leu Ser Ser Ser Asn Asn Lys Asn Tyr
1 5 10
<210> 175
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的L-CDR2
<400> 175
Trp Ala Ser
1
<210> 176
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的L-CDR3
<400> 176
Gln Gln Tyr Tyr Ser Thr Pro Ser Thr
1 5
<210> 177
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的SCFV
<400> 177
caggtgcagc tggtggagtc tgggggaggc gtggtacagc ctggggggtc cctgagactc 60
acctgtgtgg gctctggatt caagttcgaa gatcacgcca tccactgggt ccgtcaacgt 120
ccagggaagg gtctggagtg ggtctccgtt ataagtggca atggcgatga cacatactat 180
gcagattctg cgaagggccg attcaccatt tccagagaca acagcaaaaa ctccctgtat 240
ctgcaaatga acagt 255
<210> 178
<211> 114
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的VH2
<400> 178
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Thr Cys Val Gly Ser Gly Phe Lys Phe Glu Asp His
20 25 30
Ala Ile His Trp Val Arg Gln Arg Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Ser Gly Asn Gly Asp Asp Thr Tyr Tyr Ala Asp Ser Ala
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Gly Pro Gly Leu Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ser
<210> 179
<211> 113
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的VL2
<400> 179
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Ser Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln
35 40 45
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Asn Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Thr Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 180
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的H-FR1
<400> 180
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Thr Cys Val Gly Ser
20 25
<210> 181
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的H-FR2
<400> 181
Ile His Trp Val Arg Gln Arg Pro Gly Lys Gly Leu Glu Trp Val Ser
1 5 10 15
Val
<210> 182
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的H-FR3
<400> 182
Tyr Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 183
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的H-FR4
<400> 183
Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 184
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的L-FR1
<400> 184
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser
20 25
<210> 185
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的L-FR2
<400> 185
Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 186
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的L-FR3
<400> 186
Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln
20 25 30
Ala Glu Asp Val
35
<210> 187
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H01的L-FR4
<400> 187
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 188
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的H-CDR1
<400> 188
Gly Phe Thr Phe Gly Asp Tyr Ala
1 5
<210> 189
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的H-CDR2
<400> 189
Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr
1 5 10
<210> 190
<211> 15
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的H-CDR3
<400> 190
Ala Arg Asp Pro Ala Lys Glu Arg Ser Arg Asn Trp Phe Ala Pro
1 5 10 15
<210> 191
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的L-CDR1
<400> 191
Gln Ser Ile Gly Ser Trp
1 5
<210> 192
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的L-CDR2
<400> 192
Lys Ala Ser
1
<210> 193
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的L-CDR3
<400> 193
Gln Gln Tyr Lys Leu Tyr Pro Trp Thr
1 5
<210> 194
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的SCFV
<400> 194
caggtgcagc tggtgcagtc tgggggaggc ttggtaaagc cagggcggtc cctgagactc 60
tcctgtacag cttctggatt cacctttggt gattatgcta tgagctggtt ccgccaggct 120
ccagggaagg ggctggagtg ggtaggtttc attagaagca aagcttatgg tgggacaaca 180
gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caaaagcatc 240
gcctatctgc aaatg 255
<210> 195
<211> 124
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的VH2
<400> 195
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
20 25 30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65 70 75 80
Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ala Arg Asp Pro Ala Lys Glu Arg Ser Arg Asn Trp Phe Ala
100 105 110
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 196
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的VL2
<400> 196
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Leu Tyr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 197
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的H-FR1
<400> 197
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser
20 25
<210> 198
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的H-FR2
<400> 198
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
1 5 10 15
Phe
<210> 199
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的H-FR3
<400> 199
Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
1 5 10 15
Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 200
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的H-FR4
<400> 200
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 201
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的L-FR1
<400> 201
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 202
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的L-FR2
<400> 202
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 203
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的L-FR3
<400> 203
Ile Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
20 25 30
Pro Asp Asp Phe
35
<210> 204
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H02的L-FR4
<400> 204
Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
1 5 10
<210> 205
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的H-CDR1
<400> 205
Gly Tyr Thr Phe Ser Arg His Trp
1 5
<210> 206
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的H-CDR2
<400> 206
Ile His Pro Ala Asp Ser Asp Thr
1 5
<210> 207
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的H-CDR3
<400> 207
Ile Thr Glu Asp Ser Gly Arg Phe Asn
1 5
<210> 208
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的L-CDR1
<400> 208
Gln Ser Ile Gly Asn Tyr
1 5
<210> 209
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的L-CDR2
<400> 209
Ala Ser Ser
1
<210> 210
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的L-CDR3
<400> 210
Gln Gln Thr Tyr Asn Thr Pro Pro Ile Thr
1 5 10
<210> 211
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的SCFV
<400> 211
caggtgcagc tggtgcagtc tggagcagaa gtgaaaaagc ccggtgactc tctgaaaatc 60
tcttgtgagg cttctggcta cacgtttagt aggcattgga tcgtttgggt gcgccagatg 120
cccggaaaag gcctggagtg gatggggatg atccaccctg ctgactctga caccagatat 180
agcccgtcat tcggaggcca ggtcaccatg tcagtcgaca agtcagccac caccgcctac 240
ctgcagtgga gcagc 255
<210> 212
<211> 116
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的VH2
<400> 212
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Asp
1 5 10 15
Ser Leu Lys Ile Ser Cys Glu Ala Ser Gly Tyr Thr Phe Ser Arg His
20 25 30
Trp Ile Val Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Gly Met Ile His Pro Ala Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
50 55 60
Gly Gly Gln Val Thr Met Ser Val Asp Lys Ser Ala Thr Thr Ala Tyr
65 70 75 80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ile Thr Glu Asp Ser Gly Arg Phe Asn Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 213
<211> 108
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的VL2
<400> 213
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Asn Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Ala Ser Ser Ser Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Asn Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Thr Tyr Asn Thr Pro Pro
85 90 95
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105
<210> 214
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的H-FR1
<400> 214
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Asp
1 5 10 15
Ser Leu Lys Ile Ser Cys Glu Ala Ser
20 25
<210> 215
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的H-FR2
<400> 215
Ile Val Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly
1 5 10 15
Met
<210> 216
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的H-FR3
<400> 216
Arg Tyr Ser Pro Ser Phe Gly Gly Gln Val Thr Met Ser Val Asp Lys
1 5 10 15
Ser Ala Thr Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp
20 25 30
Thr Ala Met Tyr Tyr Cys
35
<210> 217
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的H-FR4
<400> 217
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 218
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的L-FR1
<400> 218
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 219
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的L-FR2
<400> 219
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 220
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的L-FR3
<400> 220
Ile Tyr Ala Ser Ser Ser Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Asn Leu Thr Ile Ser Asn Leu Gln
20 25 30
Pro Glu Asp Phe
35
<210> 221
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-01H11的L-FR4
<400> 221
Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
1 5 10
<210> 222
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的H-CDR1
<400> 222
Gly Asp Thr Leu Thr Tyr Arg Phe
1 5
<210> 223
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的H-CDR2
<400> 223
Ile Thr Pro Phe Asn Asp Asn Thr
1 5
<210> 224
<211> 13
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的H-CDR3
<400> 224
Ala Thr Gly Gly Gly Asn Asn Tyr Tyr Gly Met Glu Val
1 5 10
<210> 225
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的L-CDR1
<400> 225
Lys Leu Gly Asp Lys Phe
1 5
<210> 226
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的L-CDR2
<400> 226
Gln Asp Ala
1
<210> 227
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的L-CDR3
<400> 227
Gln Ala Trp Asp Ser Ser Ser Val Val
1 5
<210> 228
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的SCFV
<400> 228
cagatgcagc tggtggagtc tggggctgag gtgaagaaga ctgggtcctc agtgaaggtt 60
tcctgcaagg cttccggaga caccctcacc taccgcttcc tgcactgggt gcgacaggcc 120
cccggacaag cgcctgagtg gatgggatgg atcacacctt tcaatgataa caccaactac 180
gcacagaaat tccaggacag agtcaccatt accagggaca ggtctatgag cacagcctac 240
atggagctga gcagc 255
<210> 229
<211> 120
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的VH2
<400> 229
Gln Met Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Thr Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Leu Thr Tyr Arg
20 25 30
Phe Leu His Trp Val Arg Gln Ala Pro Gly Gln Ala Pro Glu Trp Met
35 40 45
Gly Trp Ile Thr Pro Phe Asn Asp Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Arg Asp Arg Ser Met Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Gly Gly Gly Asn Asn Tyr Tyr Gly Met Glu Val Trp Gly Gln
100 105 110
Gly Thr Pro Ile Thr Val Ser Ser
115 120
<210> 230
<211> 106
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的VL2
<400> 230
Ser Tyr Glu Leu Thr Gln Pro Leu Ser Leu Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Phe Thr
20 25 30
Ser Trp Tyr Gln Gln Gln Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
35 40 45
Gln Asp Ala Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Ser Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ser Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Ser Val Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 231
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的H-FR1
<400> 231
Gln Met Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Thr Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 232
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的H-FR2
<400> 232
Leu His Trp Val Arg Gln Ala Pro Gly Gln Ala Pro Glu Trp Met Gly
1 5 10 15
Trp
<210> 233
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的H-FR3
<400> 233
Asn Tyr Ala Gln Lys Phe Gln Asp Arg Val Thr Ile Thr Arg Asp Arg
1 5 10 15
Ser Met Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 234
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的H-FR4
<400> 234
Trp Gly Gln Gly Thr Pro Ile Thr Val Ser Ser
1 5 10
<210> 235
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的L-FR1
<400> 235
Ser Tyr Glu Leu Thr Gln Pro Leu Ser Leu Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Ser Ile Thr Cys Ser Gly Asp
20 25
<210> 236
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的L-FR2
<400> 236
Thr Ser Trp Tyr Gln Gln Gln Pro Gly Gln Ser Pro Val Leu Val Ile
1 5 10 15
Tyr
<210> 237
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的L-FR3
<400> 237
Ile Tyr Gln Asp Ala Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser
1 5 10 15
Gly Ser Asn Ser Gly Ser Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln
20 25 30
Ser Met Asp Glu
35
<210> 238
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02A02的L-FR4
<400> 238
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
1 5 10
<210> 239
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的H-CDR1
<400> 239
Gly Phe Thr Phe Ser Asn Tyr Gly
1 5
<210> 240
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的H-CDR2
<400> 240
Ile Trp Phe Asp Gly Ser Asn Lys
1 5
<210> 241
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的H-CDR3
<400> 241
Ala Lys Ala Ala His Leu Trp Gly Ala Phe Asp Ile
1 5 10
<210> 242
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的L-CDR1
<400> 242
Gln Ser Val Ser Ser Tyr
1 5
<210> 243
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的L-CDR2
<400> 243
Gly Ala Ser
1
<210> 244
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的L-CDR3
<400> 244
Gln Gln Tyr Ala Thr Ser Pro Leu Ser
1 5
<210> 245
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的SCFV
<400> 245
caggtgcagc tggtgcagtc tgggggaggt gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cgtctggatt caccttcagt aactatggca tgcactgggt ccgccaggct 120
ccaggcaagg ggctggaatg gatggcattt atatggtttg atggaagtaa taaattctat 180
gcagactccg tgaagggccg attcaccgtc tccagagaca attccaagaa caccctgttt 240
ctgcaaatga acagt 255
<210> 246
<211> 119
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的VH2
<400> 246
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Ala Phe Ile Trp Phe Asp Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Ala His Leu Trp Gly Ala Phe Asp Ile Trp Gly Gln Gly
100 105 110
Thr Met Val Thr Val Ser Ser
115
<210> 247
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的VL2
<400> 247
Asp Ile Gln Met Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Gly Arg Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Thr Ser Pro Leu
85 90 95
Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 248
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的H-FR1
<400> 248
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 249
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的H-FR2
<400> 249
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Ala
1 5 10 15
Phe
<210> 250
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的H-FR3
<400> 250
Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 251
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的H-FR4
<400> 251
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
1 5 10
<210> 252
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的L-FR1
<400> 252
Asp Ile Gln Met Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
20 25
<210> 253
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的L-FR2
<400> 253
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
1 5 10 15
Tyr
<210> 254
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的L-FR3
<400> 254
Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Gly Arg Leu Glu
20 25 30
Pro Glu Asp Phe
35
<210> 255
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B01的L-FR4
<400> 255
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 256
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的H-CDR1
<400> 256
Gly Phe Thr Phe Asn Arg His Val
1 5
<210> 257
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的H-CDR2
<400> 257
Ile Ser Asn Asp Gly Ser Lys Gln
1 5
<210> 258
<211> 14
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的H-CDR3
<400> 258
Ala Ser Asp Lys Arg Gly Trp Thr Leu Asn Gly Met Asp Val
1 5 10
<210> 259
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的L-CDR1
<400> 259
Ser Ser Asp Val Gly Ser Tyr Asn Leu
1 5
<210> 260
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的L-CDR2
<400> 260
Glu Val Thr
1
<210> 261
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的L-CDR3
<400> 261
Phe Ser Tyr Ala Gly Arg Gly Val Val
1 5
<210> 262
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的SCFV
<400> 262
caggtgcagc tggtagagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc 60
tcatgtgaag tcgctggatt caccttcaat agacatgtta tgcactgggt ccgccaggct 120
ccaggcaagg ggctggagtg gatggctttt atttcaaatg atggaagtaa gcaagtctac 180
gcagactccg tgaagggacg cttcaccatc tccagagaca attccaagaa cactctgtat 240
ctgcagatga ccgac 255
<210> 263
<211> 121
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的VH2
<400> 263
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Val Ala Gly Phe Thr Phe Asn Arg His
20 25 30
Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
35 40 45
Ala Phe Ile Ser Asn Asp Gly Ser Lys Gln Val Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Thr Asp Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Asp Lys Arg Gly Trp Thr Leu Asn Gly Met Asp Val Trp Gly
100 105 110
Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 264
<211> 109
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的VL2
<400> 264
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Ile Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Ser Asp Arg Phe
50 55 60
Ser Ala Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Val Glu Asp Glu Ala Asp Tyr Tyr Cys Phe Ser Tyr Ala Gly Arg
85 90 95
Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 265
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的H-FR1
<400> 265
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Val Ala
20 25
<210> 266
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的H-FR2
<400> 266
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Ala
1 5 10 15
Phe
<210> 267
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的H-FR3
<400> 267
Val Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Thr Leu Tyr Leu Gln Met Thr Asp Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 268
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的H-FR4
<400> 268
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 269
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的L-FR1
<400> 269
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr
20 25
<210> 270
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的L-FR2
<400> 270
Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Ile Ile
1 5 10 15
Tyr
<210> 271
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的L-FR3
<400> 271
Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Ser Asp Arg Phe Ser
1 5 10 15
Ala Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln
20 25 30
Val Glu Asp Glu
35
<210> 272
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B02的L-FR4
<400> 272
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
1 5 10
<210> 273
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的H-CDR1
<400> 273
Gly Phe Thr Phe Ser Ser Tyr Ala
1 5
<210> 274
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的H-CDR2
<400> 274
Ile Ser Tyr Asp Gly Ser Asn Lys
1 5
<210> 275
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的H-CDR3
<400> 275
Met Arg Asp Arg Ser Thr Gly Glu Ile Pro His
1 5 10
<210> 276
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的L-CDR1
<400> 276
Gln Thr Val Leu Asn Ser Phe Asn Asn Lys Asn Tyr
1 5 10
<210> 277
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的L-CDR2
<400> 277
Trp Ala Ser
1
<210> 278
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的L-CDR3
<400> 278
Gln Gln Tyr Ser Ser Thr Pro Pro Ile Thr
1 5 10
<210> 279
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的SCFV
<400> 279
caggtgcagc tggtacagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa caaatactat 180
gcaaactccg tgaagggccg attcatcatc tccagagaca attccaacaa tacggtgtat 240
ctgcaaatga acgcc 255
<210> 280
<211> 118
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的VH2
<400> 280
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asn Ser Val
50 55 60
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Asn Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ala Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Met Arg Asp Arg Ser Thr Gly Glu Ile Pro His Trp Gly Gln Gly Thr
100 105 110
Leu Ile Thr Val Ser Ser
115
<210> 281
<211> 114
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的VL2
<400> 281
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Val Leu Asn Ser
20 25 30
Phe Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Ser Ser Thr Pro Pro Ile Thr Phe Gly Pro Gly Thr Arg Leu Glu
100 105 110
Ile Lys
<210> 282
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的H-FR1
<400> 282
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 283
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的H-FR2
<400> 283
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
1 5 10 15
Val
<210> 284
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的H-FR3
<400> 284
Tyr Tyr Ala Asn Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn
1 5 10 15
Ser Asn Asn Thr Val Tyr Leu Gln Met Asn Ala Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 285
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的H-FR4
<400> 285
Trp Gly Gln Gly Thr Leu Ile Thr Val Ser Ser
1 5 10
<210> 286
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的L-FR1
<400> 286
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser
20 25
<210> 287
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的L-FR2
<400> 287
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 288
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的L-FR3
<400> 288
Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
20 25 30
Ala Glu Asp Val
35
<210> 289
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B06的L-FR4
<400> 289
Phe Gly Pro Gly Thr Arg Leu Glu Ile Lys
1 5 10
<210> 290
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的H-CDR1
<400> 290
Gly Asp Ser Val Ser Ser Asn Ser Ala Ala
1 5 10
<210> 291
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的H-CDR2
<400> 291
Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn
1 5
<210> 292
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的H-CDR3
<400> 292
Ala Lys Ser Tyr Ala Gly Pro Ile Ser Tyr Tyr Tyr Tyr Gly Leu Asp
1 5 10 15
Val
<210> 293
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的L-CDR1
<400> 293
Ser Ser Asp Ile Gly Arg Tyr Asn Leu
1 5
<210> 294
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的L-CDR2
<400> 294
Gly Gly Ser
1
<210> 295
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的L-CDR3
<400> 295
Ser Ser Tyr Ala Ser Ser Ser Thr Pro Tyr Val
1 5 10
<210> 296
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的SCFV
<400> 296
caggtgcagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60
acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg 120
cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat 180
aatgattatg cagtatctgt gaaaagtcga ataaccatca acccagacac atccaagaac 240
cagttctccc tgcag 255
<210> 297
<211> 127
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的VH2
<400> 297
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn
20 25 30
Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu
35 40 45
Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala
50 55 60
Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn
65 70 75 80
Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Ala Val Asp Thr Ala Val
85 90 95
Tyr Tyr Cys Ala Lys Ser Tyr Ala Gly Pro Ile Ser Tyr Tyr Tyr Tyr
100 105 110
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 298
<211> 111
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的VL2
<400> 298
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Arg Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Gly Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Asn Ser Asp Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Ser Ser
85 90 95
Ser Thr Pro Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 299
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的H-FR1
<400> 299
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Ile Ser
20 25
<210> 300
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的H-FR2
<400> 300
Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly
1 5 10 15
Arg
<210> 301
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的H-FR3
<400> 301
Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr
1 5 10 15
Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Ala Val Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 302
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的H-FR4
<400> 302
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 303
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的L-FR1
<400> 303
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr
20 25
<210> 304
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的L-FR2
<400> 304
Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile
1 5 10 15
Tyr
<210> 305
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的L-FR3
<400> 305
Ile Tyr Gly Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser
1 5 10 15
Gly Ser Asn Ser Asp Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Arg
20 25 30
Ala Glu Asp Glu
35
<210> 306
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B08的L-FR4
<400> 306
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 307
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的H-CDR1
<400> 307
Gly Gly Thr Phe Ser Arg Asn Thr
1 5
<210> 308
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的H-CDR2
<400> 308
Ile Ile Pro Ile Phe His Ile Thr
1 5
<210> 309
<211> 13
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的H-CDR3
<400> 309
Ala Arg Gly Ser Thr Thr Phe Pro Arg Tyr Phe Asp Tyr
1 5 10
<210> 310
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的L-CDR1
<400> 310
Gln Ser Val Gly Ser Tyr
1 5
<210> 311
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的L-CDR2
<400> 311
Asp Ala Ser
1
<210> 312
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的L-CDR3
<400> 312
Gln Gln Tyr Gly Arg Ser Pro Phe Thr
1 5
<210> 313
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的SCFV
<400> 313
caggtgcagc tggtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60
tcctgcaagg cttctggagg caccttcagc agaaatactt tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttcatat aacaaattac 180
gcacagaaga tgcagggcag agtcacgatt tccgcggacg agtccacggg cacagtctag 240
atggagctga gcagg 255
<210> 314
<211> 120
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的VH2
<400> 314
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Asn
20 25 30
Thr Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe His Ile Thr Asn Tyr Ala Gln Lys Met
50 55 60
Gln Gly Arg Val Thr Ile Ser Ala Asp Glu Ser Thr Gly Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Ser Thr Thr Phe Pro Arg Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 315
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的VL2
<400> 315
Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Arg Leu Leu Val
35 40 45
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Arg Ser Pro Phe
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 316
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的H-FR1
<400> 316
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 317
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的H-FR2
<400> 317
Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Gly
<210> 318
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的H-FR3
<400> 318
Asn Tyr Ala Gln Lys Met Gln Gly Arg Val Thr Ile Ser Ala Asp Glu
1 5 10 15
Ser Thr Gly Thr Val Tyr Met Glu Leu Ser Arg Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 319
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的H-FR4
<400> 319
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 320
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的L-FR1
<400> 320
Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
20 25
<210> 321
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的L-FR2
<400> 321
Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Arg Leu Leu Val
1 5 10 15
Tyr
<210> 322
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的L-FR3
<400> 322
Val Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
20 25 30
Pro Glu Asp Phe
35
<210> 323
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02B10的L-FR4
<400> 323
Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
1 5 10
<210> 324
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的H-CDR1
<400> 324
Gly Phe Thr Phe Ser Thr Tyr Gly
1 5
<210> 325
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的H-CDR2
<400> 325
Ile Ser Gly Gly Gly Ser Ser Thr
1 5
<210> 326
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的H-CDR3
<400> 326
Ala Arg Trp Gly Val Met Leu Ser Phe Asp Tyr
1 5 10
<210> 327
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的L-CDR1
<400> 327
Tyr Ser Val Ser Pro Trp
1 5
<210> 328
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的L-CDR2
<400> 328
Lys Ala Ser
1
<210> 329
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的L-CDR3
<400> 329
Gln Gln Phe Asn Ser Tyr Met Met Tyr Thr
1 5 10
<210> 330
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的SCFV
<400> 330
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctgggaaatc cctgagactc 60
tcctgtgcag cctctggatt caccttcagc acctatggca tgacttgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcaggg attagtggtg ggggttctag cacaaactac 180
gcagactccg tgaagggccg cttcatcatt tctagagaca actctaacaa cacgctgtat 240
ctgcaaatga acagt 255
<210> 331
<211> 118
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的VH2
<400> 331
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Lys
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Gly Gly Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Gly Val Met Leu Ser Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Pro Val Thr Val Ser Ser
115
<210> 332
<211> 108
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的VL2
<400> 332
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Pro Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Tyr Ser Val Ser Pro Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Met Met
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 333
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的H-FR1
<400> 333
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Lys
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 334
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的H-FR2
<400> 334
Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
1 5 10 15
Gly
<210> 335
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的H-FR3
<400> 335
Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn
1 5 10 15
Ser Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 336
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的H-FR4
<400> 336
Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser
1 5 10
<210> 337
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的L-FR1
<400> 337
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Pro Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 338
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的L-FR2
<400> 338
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 339
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的L-FR3
<400> 339
Ile Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
20 25 30
Pro Asp Asp Phe
35
<210> 340
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C06的L-FR4
<400> 340
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
1 5 10
<210> 341
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的H-CDR1
<400> 341
Gly Val Thr Phe Ser Gly Tyr Val
1 5
<210> 342
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的H-CDR2
<400> 342
Ile Ile Pro Leu Ile Asp Val Glu
1 5
<210> 343
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的H-CDR3
<400> 343
Ala Lys Ser Val Val Arg Gly Leu Asp Tyr Tyr Tyr Tyr Gly Phe Asp
1 5 10 15
Val
<210> 344
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的L-CDR1
<400> 344
Asn Ile Gly Ser Lys Ser
1 5
<210> 345
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的L-CDR2
<400> 345
Tyr Asp Gly
1
<210> 346
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的L-CDR3
<400> 346
Gln Val Trp Asp Ser Ser Ser Asp Gln Gly Val
1 5 10
<210> 347
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的SCFV
<400> 347
caggtgcagc tggtggagtc tggggctgag gtgaggaggc ctgggtcctc ggtgaaggtc 60
tcctgcaaga cttcgggagt caccttcagc ggctatgttc tgagctgggt gcgacaggcc 120
cctggacacg gccttgagtg gatgggacgg atcatccctt taattgacgt ggaaaactat 180
gcacgggagt tccagggtag aatgaagatc accgcagaca agtccacgaa tacagtctac 240
atggaactga acaac 255
<210> 348
<211> 124
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的VH2
<400> 348
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Arg Arg Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Val Thr Phe Ser Gly Tyr
20 25 30
Val Leu Ser Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Leu Ile Asp Val Glu Asn Tyr Ala Arg Glu Phe
50 55 60
Gln Gly Arg Met Lys Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr
65 70 75 80
Met Glu Leu Asn Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Val Val Arg Gly Leu Asp Tyr Tyr Tyr Tyr Gly Phe Asp
100 105 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 349
<211> 108
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的VL2
<400> 349
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Leu Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Val Thr Tyr
35 40 45
Tyr Asp Gly Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Ile Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Gln
85 90 95
Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 350
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的H-FR1
<400> 350
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Arg Arg Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser
20 25
<210> 351
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的H-FR2
<400> 351
Leu Ser Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met Gly
1 5 10 15
Arg
<210> 352
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的H-FR3
<400> 352
Asn Tyr Ala Arg Glu Phe Gln Gly Arg Met Lys Ile Thr Ala Asp Lys
1 5 10 15
Ser Thr Asn Thr Val Tyr Met Glu Leu Asn Asn Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 353
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的H-FR4
<400> 353
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 354
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的L-FR1
<400> 354
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Leu Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Arg Ile Thr Cys Gly Gly Asn
20 25
<210> 355
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的L-FR2
<400> 355
Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Val Thr
1 5 10 15
Tyr
<210> 356
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的L-FR3
<400> 356
Thr Tyr Tyr Asp Gly Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser
1 5 10 15
Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Ile Ile Ser Arg Val Glu
20 25 30
Ala Gly Asp Glu
35
<210> 357
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C07的L-FR4
<400> 357
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 358
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的H-CDR1
<400> 358
Gly Gly Thr Phe Ser Ser Tyr Thr
1 5
<210> 359
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的H-CDR2
<400> 359
Ile Ile Pro Ile Leu Gly Ile Ala
1 5
<210> 360
<211> 18
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的H-CDR3
<400> 360
Ala Lys Asp Met Val Arg Gly Phe Arg His Tyr Tyr Tyr Tyr Gly Met
1 5 10 15
Asp Val
<210> 361
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的L-CDR1
<400> 361
Asn Ser Asp Val Gly Asp Tyr Asn Leu
1 5
<210> 362
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的L-CDR2
<400> 362
Glu Val Thr
1
<210> 363
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的L-CDR3
<400> 363
Ser Ser Tyr Thr Ser Ser Ser Thr Tyr Val
1 5 10
<210> 364
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的SCFV
<400> 364
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60
tcctgcaagg cttctggagg caccttcagc agctatacta tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac 180
gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac 240
atggagctga gcagc 255
<210> 365
<211> 125
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的VH2
<400> 365
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Met Val Arg Gly Phe Arg His Tyr Tyr Tyr Tyr Gly Met
100 105 110
Asp Val Trp Gly Pro Gly Thr Lys Val Thr Val Ser Ser
115 120 125
<210> 366
<211> 110
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的VL2
<400> 366
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Asp Tyr
20 25 30
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 367
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的H-FR1
<400> 367
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 368
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的H-FR2
<400> 368
Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Arg
<210> 369
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的H-FR3
<400> 369
Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys
1 5 10 15
Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 370
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的H-FR4
<400> 370
Trp Gly Pro Gly Thr Lys Val Thr Val Ser Ser
1 5 10
<210> 371
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的L-FR1
<400> 371
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr
20 25
<210> 372
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的L-FR2
<400> 372
Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile
1 5 10 15
Tyr
<210> 373
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的L-FR3
<400> 373
Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser
1 5 10 15
Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln
20 25 30
Ala Glu Asp Glu
35
<210> 374
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02C09的L-FR4
<400> 374
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 375
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的H-CDR1
<400> 375
Gly Phe Thr Phe Lys Asn Phe Ala
1 5
<210> 376
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的H-CDR2
<400> 376
Ile Asn Gly Asp Gly Ser Asp Thr
1 5
<210> 377
<211> 14
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的H-CDR3
<400> 377
Ala Lys Glu Ile Ala Glu Val Gly Arg Pro Asn Phe Asp Tyr
1 5 10
<210> 378
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的L-CDR1
<400> 378
Gln Ser Val Thr Ser Thr Tyr
1 5
<210> 379
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的L-CDR2
<400> 379
Gly Ala Ser
1
<210> 380
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的L-CDR3
<400> 380
Gln Gln Tyr Gly Ser Ser Pro Tyr Thr
1 5
<210> 381
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的SCFV
<400> 381
caggtgcagc tggtagagtc cgggggaggc ttagttgagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcaaa aacttcgcga tgtactgggt ccgccaagct 120
ccagggaagg ggctggtgtg ggtctcacgt attaatggtg atgggagtga cacaacgtac 180
gcggagtccg tgaagggccg attcaccacc tccagagaca acgccaagaa cacagtgtat 240
ttgcaaatga acagt 255
<210> 382
<211> 121
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的VH2
<400> 382
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Asn Phe
20 25 30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val
35 40 45
Ser Arg Ile Asn Gly Asp Gly Ser Asp Thr Thr Tyr Ala Glu Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Ile Ala Glu Val Gly Arg Pro Asn Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 383
<211> 108
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的VL2
<400> 383
Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Asp Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Thr
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Ser Gly Ala Ser Ser Arg Ala Ala Gly Ile Pro Ala Arg Phe Thr
50 55 60
Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
85 90 95
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 384
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的H-FR1
<400> 384
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 385
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的H-FR2
<400> 385
Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val Ser
1 5 10 15
Arg
<210> 386
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的H-FR3
<400> 386
Thr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn
1 5 10 15
Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 387
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的H-FR4
<400> 387
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 388
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的L-FR1
<400> 388
Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Asp Thr Ala Thr Leu Ser Cys Arg Ala Ser
20 25
<210> 389
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的L-FR2
<400> 389
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
1 5 10 15
Ser
<210> 390
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的L-FR3
<400> 390
Ile Ser Gly Ala Ser Ser Arg Ala Ala Gly Ile Pro Ala Arg Phe Thr
1 5 10 15
Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
20 25 30
Pro Glu Asp Phe
35
<210> 391
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02D04的L-FR4
<400> 391
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
1 5 10
<210> 392
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的H-CDR1
<400> 392
Gly Gly Ser Ser Ser Asn Tyr Ala
1 5
<210> 393
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的H-CDR2
<400> 393
Ile Thr Pro Phe Asn Gly Asn Thr
1 5
<210> 394
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的H-CDR3
<400> 394
Ala Ser Ser Arg Gly Arg Phe Gln Trp Phe Asp Tyr
1 5 10
<210> 395
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的L-CDR1
<400> 395
Gln Ser Val Lys Asn Asn Asp
1 5
<210> 396
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的L-CDR2
<400> 396
Gly Thr Ser
1
<210> 397
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的L-CDR3
<400> 397
Gln Gln Phe Gly Gly Ser Pro Pro Trp Thr
1 5 10
<210> 398
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的SCFV
<400> 398
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60
tcctgcaagg cttccggagg ctcctccagc aactatgcta tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatgg atcacacctt tcaatggtaa caccagctac 180
gcgcagatat tccaggacag agtcaccatt accagggaca ggtctatgag cacagcctac 240
atggagctga gcagc 255
<210> 399
<211> 119
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的VH2
<400> 399
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Ser Ser Asn Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Trp Ile Thr Pro Phe Asn Gly Asn Thr Ser Tyr Ala Gln Ile Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Arg Asp Arg Ser Met Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ser Ser Arg Gly Arg Phe Gln Trp Phe Asp Tyr Trp Gly Pro Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 400
<211> 109
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的VL2
<400> 400
Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ser Val Lys Asn Asn
20 25 30
Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Thr Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Gly Ser Pro
85 90 95
Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 401
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的H-FR1
<400> 401
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 402
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的H-FR2
<400> 402
Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Trp
<210> 403
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的H-FR3
<400> 403
Ser Tyr Ala Gln Ile Phe Gln Asp Arg Val Thr Ile Thr Arg Asp Arg
1 5 10 15
Ser Met Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 404
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的H-FR4
<400> 404
Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 405
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的L-FR1
<400> 405
Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser
20 25
<210> 406
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的L-FR2
<400> 406
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
1 5 10 15
Tyr
<210> 407
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的L-FR3
<400> 407
Ile Tyr Gly Thr Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu
20 25 30
Pro Glu Asp Phe
35
<210> 408
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E01的L-FR4
<400> 408
Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
1 5 10
<210> 409
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的H-CDR1
<400> 409
Gly Phe Thr Ser Gly Asp Tyr Ala
1 5
<210> 410
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的H-CDR2
<400> 410
Ile Gly Ser Ser Gly Tyr Gly Gly Pro Thr
1 5 10
<210> 411
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的H-CDR3
<400> 411
Ala Arg Asp Leu Gly Phe Gly Tyr Ser Gly Tyr Arg Asn Ala Phe Asp
1 5 10 15
Ser
<210> 412
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的L-CDR1
<400> 412
Gly Gly Thr Phe Ala Ser Asp Ser
1 5
<210> 413
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的L-CDR2
<400> 413
Glu Gly Asp
1
<210> 414
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的L-CDR3
<400> 414
Gln Ser Tyr Asp Ser Ser Asn Gln Val
1 5
<210> 415
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的SCFV
<400> 415
caggtgcagc tggtagagtc tgggggaggc tgggtacagc cagggcggtc cctgagactc 60
tcctgtacag tctctggatt cacgtctggt gattatgctg tgagttgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtaggtgtc attggaagca gcggttatgg tgggccaaca 180
aaatatgctg cgtctgtgga aggcagattc accatctcaa gagatgattc caaagacatc 240
gcctatctgc aaatg 255
<210> 416
<211> 126
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的VH2
<400> 416
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Thr Ser Gly Asp Tyr
20 25 30
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Val Ile Gly Ser Ser Gly Tyr Gly Gly Pro Thr Lys Tyr Ala Ala
50 55 60
Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asp Ile
65 70 75 80
Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ala Arg Asp Leu Gly Phe Gly Tyr Ser Gly Tyr Arg Asn Ala
100 105 110
Phe Asp Ser Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120 125
<210> 417
<211> 110
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的VL2
<400> 417
Gln Leu Val Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser Gly Gly Thr Phe Ala Ser Asp
20 25 30
Ser Val Gln Trp Tyr Arg Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Ile Tyr Glu Gly Asp Arg Arg Ala Ser Gly Val Pro Gly Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
85 90 95
Ser Asn Gln Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 418
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的H-FR1
<400> 418
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Val Ser
20 25
<210> 419
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的H-FR2
<400> 419
Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
1 5 10 15
Val
<210> 420
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的H-FR3
<400> 420
Lys Tyr Ala Ala Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp
1 5 10 15
Ser Lys Asp Ile Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 421
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的H-FR4
<400> 421
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
1 5 10
<210> 422
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的L-FR1
<400> 422
Gln Leu Val Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Gly Ser
20 25
<210> 423
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的L-FR2
<400> 423
Val Gln Trp Tyr Arg Gln Arg Pro Gly Ser Ala Pro Thr Thr Val Ile
1 5 10 15
Tyr
<210> 424
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的L-FR3
<400> 424
Ile Tyr Glu Gly Asp Arg Arg Ala Ser Gly Val Pro Gly Arg Phe Ser
1 5 10 15
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
20 25 30
Leu Lys Ala Glu
35
<210> 425
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02E05的L-FR4
<400> 425
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 426
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的H-CDR1
<400> 426
Gly Phe Ser Phe Ser Gly Tyr Ala
1 5
<210> 427
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的H-CDR2
<400> 427
Ile Trp Phe Asp Gly Ser Thr Lys
1 5
<210> 428
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的H-CDR3
<400> 428
Ala Arg Met Phe Arg Gly Ser Phe Asp Tyr
1 5 10
<210> 429
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的L-CDR1
<400> 429
Gln Ser Leu Val His Arg Asp Gly Asn Thr Tyr
1 5 10
<210> 430
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的L-CDR2
<400> 430
Lys Ile Ser
1
<210> 431
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的L-CDR3
<400> 431
Met Gln Ala Thr Arg Leu Trp Thr
1 5
<210> 432
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的SCFV
<400> 432
caggtgcagc tggtggagtc tgggggaggt gtggtccagc ctggggcgtc cctgaaactc 60
tcctgtgcag cgtccggatt cagcttcagt ggctatgcca tgcactgggt ccgccaggct 120
ccaggcatgg ggctggagtg ggtggcagtt atctggtttg atggaagtac taaatactat 180
gcagactccg tgaagggccg attcaccatc tcccgagaca attccaagaa tacacttttt 240
ctgcaaatga acagt 255
<210> 433
<211> 117
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的VH2
<400> 433
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Ala
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Met Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Trp Phe Asp Gly Ser Thr Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Phe Arg Gly Ser Phe Asp Tyr Trp Gly Gln Gly Ala Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 434
<211> 111
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的VL2
<400> 434
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg
20 25 30
Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Leu Leu Ile Ser Lys Ile Ser Asn Arg Ser Ser Glu Val Ser
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Glu Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala
85 90 95
Thr Arg Leu Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 435
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的H-FR1
<400> 435
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Ala
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser
20 25
<210> 436
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的H-FR2
<400> 436
Met His Trp Val Arg Gln Ala Pro Gly Met Gly Leu Glu Trp Val Ala
1 5 10 15
Val
<210> 437
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的H-FR3
<400> 437
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 438
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的H-FR4
<400> 438
Trp Gly Gln Gly Ala Leu Val Thr Val Ser Ser
1 5 10
<210> 439
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的L-FR1
<400> 439
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser
20 25
<210> 440
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的L-FR2
<400> 440
Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile
1 5 10 15
Ser
<210> 441
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的L-FR3
<400> 441
Ile Ser Lys Ile Ser Asn Arg Ser Ser Glu Val Ser Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ala Gly Thr Glu Phe Thr Leu Lys Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 442
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-02F05的L-FR4
<400> 442
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 443
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的H-CDR1
<400> 443
Gly Phe Thr Phe Ser Asp Tyr Ala
1 5
<210> 444
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的H-CDR2
<400> 444
Ile Ser Ser Ser Gly Gly Ser Thr
1 5
<210> 445
<211> 14
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的H-CDR3
<400> 445
Ala Arg Leu Arg Pro Phe Ser Lys Ala Asp Ser Phe Asp Tyr
1 5 10
<210> 446
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的L-CDR1
<400> 446
Gln Ser Val Leu Ser Ser Ser Ser Asn Lys Asn Phe
1 5 10
<210> 447
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的L-CDR2
<400> 447
Trp Ala Ser
1
<210> 448
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的L-CDR3
<400> 448
Gln Gln Tyr Tyr Ser Ser Pro Leu Thr
1 5
<210> 449
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的SCFV
<400> 449
caggtgcagc tggtggagtc tgggggaggc ttggtacagc cgggggggtc cctgagactc 60
tcctgcagtg cctctggatt cacctttagt gactatgcca tgagctgggt ccgccaggcc 120
ccagggaagc ggctggagtg ggtctcagcg attagtagta gtggtggtag cacacactac 180
gcagacttcg tgaagggccg gttcaccatt tccagagaca aatccaagaa cacactcttt 240
ctgcaaatga acagt 255
<210> 450
<211> 121
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的VH2
<400> 450
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Ser Ser Gly Gly Ser Thr His Tyr Ala Asp Phe Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Arg Pro Phe Ser Lys Ala Asp Ser Phe Asp Tyr Trp Gly
100 105 110
Leu Gly Thr Leu Ile Thr Val Ser Ser
115 120
<210> 451
<211> 113
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的VL2
<400> 451
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Ser Ser
20 25 30
Ser Ser Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 452
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的H-FR1
<400> 452
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser
20 25
<210> 453
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的H-FR2
<400> 453
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val Ser
1 5 10 15
Ala
<210> 454
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的H-FR3
<400> 454
His Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys
1 5 10 15
Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 455
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的H-FR4
<400> 455
Trp Gly Leu Gly Thr Leu Ile Thr Val Ser Ser
1 5 10
<210> 456
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的L-FR1
<400> 456
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser
20 25
<210> 457
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的L-FR2
<400> 457
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 458
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的L-FR3
<400> 458
Ile Tyr Trp Ala Ser Ala Arg Glu Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
20 25 30
Ala Glu Asp Val
35
<210> 459
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03A09的L-FR4
<400> 459
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 460
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的H-CDR1
<400> 460
Gly Gly Asn Phe Asn Ser Tyr Ala
1 5
<210> 461
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的H-CDR2
<400> 461
Ile Ile Pro Phe Phe Thr Thr Pro
1 5
<210> 462
<211> 5
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的H-CDR3
<400> 462
Val Thr Arg Gly Ala
1 5
<210> 463
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的L-CDR1
<400> 463
Ser Ser Asp Val Gly Gly Tyr Asn Tyr
1 5
<210> 464
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的L-CDR2
<400> 464
Asp Val Thr
1
<210> 465
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的L-CDR3
<400> 465
Gln Val Trp Asp Ser Ser Ser Asp His Tyr Val
1 5 10
<210> 466
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的SCFV
<400> 466
caggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggttaaagtc 60
tcctgcaaga cttctggcgg caacttcaac agctatgcta tcaactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaagc atcatcccat tctttactac accaaactac 180
gcacagaaat tccagggcag agtcacgatt accgcggacg aatccacgaa cacagccttc 240
atggaattga gcagt 255
<210> 467
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的VH2
<400> 467
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Asn Phe Asn Ser Tyr
20 25 30
Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Ser Ile Ile Pro Phe Phe Thr Thr Pro Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Phe
65 70 75 80
Met Glu Leu Ser Ser Leu Gly Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Thr Arg Gly Ala Gln Gly Arg Gly Thr Leu Val Thr Val Ser Ser
100 105 110
<210> 468
<211> 111
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的VL2
<400> 468
Asn Phe Met Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Gln Leu
35 40 45
Ile Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val
65 70 75 80
Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser
85 90 95
Ser Asp His Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 469
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的H-FR1
<400> 469
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser
20 25
<210> 470
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的H-FR2
<400> 470
Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Ser
<210> 471
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的H-FR3
<400> 471
Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu
1 5 10 15
Ser Thr Asn Thr Ala Phe Met Glu Leu Ser Ser Leu Gly Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 472
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的H-FR4
<400> 472
Gln Gly Arg Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 473
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的L-FR1
<400> 473
Asn Phe Met Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Ser
20 25
<210> 474
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的L-FR2
<400> 474
Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Gln Leu Ile Ile
1 5 10 15
Tyr
<210> 475
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的L-FR3
<400> 475
Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser
1 5 10 15
Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu
20 25 30
Ala Gly Asp Glu
35
<210> 476
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03B03的L-FR4
<400> 476
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 477
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的H-CDR1
<400> 477
Gly Phe Thr Phe Ser Ser Tyr Ala
1 5
<210> 478
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的H-CDR2
<400> 478
Ile Ser Tyr Asp Gly Ser Asn Lys
1 5
<210> 479
<211> 15
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的H-CDR3
<400> 479
Ala Arg Asp Ala Ala Ala Met Ile Ser Pro His Gly Met Asp Val
1 5 10 15
<210> 480
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的L-CDR1
<400> 480
Gln Ser Leu Val His Ser Asp Gly Asn Ile Tyr
1 5 10
<210> 481
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的L-CDR2
<400> 481
Lys Val Ser
1
<210> 482
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的L-CDR3
<400> 482
Met Gln Gly Thr Gln Trp Pro Pro Thr
1 5
<210> 483
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的SCFV
<400> 483
cagatgcagc tggtggagtc tggaggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactac 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagc 255
<210> 484
<211> 122
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的VH2
<400> 484
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ala Ala Ala Met Ile Ser Pro His Gly Met Asp Val Trp
100 105 110
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 485
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的VL2
<400> 485
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asp Gly Asn Ile Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Gly Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr Gln Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105 110
<210> 486
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的H-FR1
<400> 486
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 487
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的H-FR2
<400> 487
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
1 5 10 15
Val
<210> 488
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的H-FR3
<400> 488
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 489
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的H-FR4
<400> 489
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 490
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的L-FR1
<400> 490
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser
20 25
<210> 491
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的L-FR2
<400> 491
Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile
1 5 10 15
Tyr
<210> 492
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的L-FR3
<400> 492
Ile Tyr Lys Val Ser Asn Arg Gly Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 493
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03D02的L-FR4
<400> 493
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
1 5 10
<210> 494
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的H-CDR1
<400> 494
Gly Phe Thr Phe Ser Ser Tyr Ala
1 5
<210> 495
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的H-CDR2
<400> 495
Ile Ser Tyr Asp Gly Ser Asn Lys
1 5
<210> 496
<211> 16
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的H-CDR3
<400> 496
Thr Pro Phe Gln His Asp Ser Val Pro Arg Arg Gly Ala Phe Asp Leu
1 5 10 15
<210> 497
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的L-CDR1
<400> 497
Gln Ser Leu Leu Ser Ser Ser Asn Asn Lys Asn Tyr
1 5 10
<210> 498
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的L-CDR2
<400> 498
Trp Ala Ser
1
<210> 499
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的L-CDR3
<400> 499
Gln Gln Tyr Tyr Thr Ser Pro Arg Thr
1 5
<210> 500
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的SCFV
<400> 500
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactac 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagt 255
<210> 501
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的VH2
<400> 501
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Pro Phe Gln His Asp Ser Val Pro Arg Arg Gly Ala Phe Asp Leu
100 105 110
Trp Gly Gln Gly Thr Lys Ile Thr Val Ser Ser
115 120
<210> 502
<211> 113
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的VL2
<400> 502
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Thr Ser Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 503
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的H-FR1
<400> 503
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 504
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的H-FR2
<400> 504
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
1 5 10 15
Val
<210> 505
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的H-FR3
<400> 505
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 506
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的H-FR4
<400> 506
Trp Gly Gln Gly Thr Lys Ile Thr Val Ser Ser
1 5 10
<210> 507
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的L-FR1
<400> 507
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser
20 25
<210> 508
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的L-FR2
<400> 508
Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 509
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的L-FR3
<400> 509
Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
20 25 30
Ala Glu Asp Val
35
<210> 510
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-03H11的L-FR4
<400> 510
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 511
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的H-CDR1
<400> 511
Gly Gly Thr Phe Thr Arg Asp Ala
1 5
<210> 512
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的H-CDR2
<400> 512
Ile Ile Pro Leu Ile Asp Thr Ala
1 5
<210> 513
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的H-CDR3
<400> 513
Ala Arg Gly Glu Met Tyr Ser Arg Ser Trp Tyr Trp Gly Ala Phe Asp
1 5 10 15
Leu
<210> 514
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的L-CDR1
<400> 514
Ser Ser Asp Val Gly Gly Tyr Asn Tyr
1 5
<210> 515
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的L-CDR2
<400> 515
Asp Val Thr
1
<210> 516
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的L-CDR3
<400> 516
Ser Ser Tyr Ser Ser Ser Thr Phe Tyr Val
1 5 10
<210> 517
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的SCFV
<400> 517
caggtgcagc tggtagagtc tggggctgag gtgaagaagc ctgggtcttc ggtgaaggtc 60
tcctgcaagg tttctggagg caccttcacc agggatgcta tcagttgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaagg atcatccctc tcattgatac agcaaattac 180
gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac 240
atgagtctaa gcagc 255
<210> 518
<211> 124
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的VH2
<400> 518
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Thr Arg Asp
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Leu Ile Asp Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Ser Leu Ser Ser Leu Gly Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Glu Met Tyr Ser Arg Ser Trp Tyr Trp Gly Ala Phe Asp
100 105 110
Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 519
<211> 110
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的VL2
<400> 519
Asn Phe Met Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Gln Leu
35 40 45
Ile Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ser Ser Ser
85 90 95
Thr Phe Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 520
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的H-FR1
<400> 520
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Val Ser
20 25
<210> 521
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的H-FR2
<400> 521
Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Arg
<210> 522
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的H-FR3
<400> 522
Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys
1 5 10 15
Ser Thr Ser Thr Ala Tyr Met Ser Leu Ser Ser Leu Gly Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 523
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的H-FR4
<400> 523
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
1 5 10
<210> 524
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的L-FR1
<400> 524
Asn Phe Met Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Ser
20 25
<210> 525
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的L-FR2
<400> 525
Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Gln Leu Ile Ile
1 5 10 15
Tyr
<210> 526
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的L-FR3
<400> 526
Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser
1 5 10 15
Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln
20 25 30
Ala Glu Asp Glu
35
<210> 527
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-07A09的L-FR4
<400> 527
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 528
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的H-CDR1
<400> 528
Gly Phe Ser Phe Ser Asn Tyr Gly
1 5
<210> 529
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的H-CDR2
<400> 529
Val Ser Phe Asp Gly Ile Lys Lys
1 5
<210> 530
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的H-CDR3
<400> 530
Ala Lys Ala Pro Val Tyr Cys Ser Gly Asp Cys Arg Phe Ala Phe Asp
1 5 10 15
Phe
<210> 531
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的L-CDR1
<400> 531
Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr
1 5 10
<210> 532
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的L-CDR2
<400> 532
Glu Val Ser
1
<210> 533
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的L-CDR3
<400> 533
Met Gln Gly Ser Tyr Thr
1 5
<210> 534
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的SCFV
<400> 534
caggtgcagc tggtggagtc agggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt cagtttcagt aattatggca tgcactgggt ccgccaggct 120
ccaggcaagg ggctgcagtg ggtggcaacc gtctcttttg atggaataaa aaaacattat 180
tcagactccg tgaagggccg tttcaccatc tccagagaca attccaagaa cacgctgtat 240
ctccaaatga acagt 255
<210> 535
<211> 124
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的VH2
<400> 535
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val
35 40 45
Ala Thr Val Ser Phe Asp Gly Ile Lys Lys His Tyr Ser Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Pro Val Tyr Cys Ser Gly Asp Cys Arg Phe Ala Phe Asp
100 105 110
Phe Trp Gly Leu Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 536
<211> 109
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的VL2
<400> 536
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
85 90 95
Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 537
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的H-FR1
<400> 537
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 538
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的H-FR2
<400> 538
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val Ala
1 5 10 15
Thr
<210> 539
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的H-FR3
<400> 539
His Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 540
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的H-FR4
<400> 540
Trp Gly Leu Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 541
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的L-FR1
<400> 541
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly
1 5 10 15
Gln Ser Ala Ser Ile Ser Cys Lys Ser Ser
20 25
<210> 542
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的L-FR2
<400> 542
Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile
1 5 10 15
Tyr
<210> 543
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的L-FR3
<400> 543
Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 544
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-08A01的L-FR4
<400> 544
Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
1 5 10
<210> 545
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的H-CDR1
<400> 545
Gly Tyr Thr Phe Thr His Tyr Asp
1 5
<210> 546
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的H-CDR2
<400> 546
Met Asn Pro Asn Lys Gly Asn Thr
1 5
<210> 547
<211> 20
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的H-CDR3
<400> 547
Ala Arg Glu Arg Val Pro Asn Ala Met Val Gly Tyr Phe Ser Phe Tyr
1 5 10 15
Gly Met Asp Val
20
<210> 548
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的L-CDR1
<400> 548
Asp Ile Thr Arg Lys Ser
1 5
<210> 549
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的L-CDR2
<400> 549
Tyr Asp Arg
1
<210> 550
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的L-CDR3
<400> 550
Gln Val Trp Asp Thr Asn Ser Val Val
1 5
<210> 551
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的SCFV
<400> 551
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaaga cctctggata caccttcacc cattatgata tcaactgggt gcgacaggcc 120
tctggacaag ggcttgagtg gatgggacgg atgaacccga ataagggaaa cacaggctat 180
gctcagaagt tccagggcag agtcaccatg accagggacg cctcgacaga cacagcctac 240
atggagctga gcagc 255
<210> 552
<211> 127
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的VH2
<400> 552
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr His Tyr
20 25 30
Asp Ile Asn Trp Val Arg Gln Ala Ser Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Arg Met Asn Pro Asn Lys Gly Asn Thr Gly Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Ala Ser Thr Asp Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Glu Arg Val Pro Asn Ala Met Val Gly Tyr Phe Ser Phe Tyr
100 105 110
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 553
<211> 106
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的VL2
<400> 553
Ser Tyr Glu Leu Thr Gln Ala Pro Ser Leu Ser Val Ala Pro Gly Glu
1 5 10 15
Thr Ala Thr Ile Thr Cys Gly Gly Asn Asp Ile Thr Arg Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Tyr Asp Arg Ala Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Glu Asn Thr Ala Ser Leu Thr Ile Ser Arg Val Glu Ala Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Asn Ser Val Val
85 90 95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 554
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的H-FR1
<400> 554
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser
20 25
<210> 555
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的H-FR2
<400> 555
Ile Asn Trp Val Arg Gln Ala Ser Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Arg
<210> 556
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的H-FR3
<400> 556
Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Ala
1 5 10 15
Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 557
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> 的H-FR4A56-10A01
<400> 557
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 558
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的L-FR1
<400> 558
Ser Tyr Glu Leu Thr Gln Ala Pro Ser Leu Ser Val Ala Pro Gly Glu
1 5 10 15
Thr Ala Thr Ile Thr Cys Gly Gly Asn
20 25
<210> 559
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的L-FR2
<400> 559
Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile
1 5 10 15
Tyr
<210> 560
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的L-FR3
<400> 560
Ile Tyr Tyr Asp Arg Ala Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser
1 5 10 15
Gly Ser Asn Ser Glu Asn Thr Ala Ser Leu Thr Ile Ser Arg Val Glu
20 25 30
Ala Gly Asp Glu
35
<210> 561
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-10A01的L-FR4
<400> 561
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
1 5 10
<210> 562
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的H-CDR1
<400> 562
Gly Phe Thr Phe Ala Asn Ala Trp
1 5
<210> 563
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的H-CDR2
<400> 563
Ile Tyr Ser Thr Ser Asp Gly Gly Ala Thr
1 5 10
<210> 564
<211> 24
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的H-CDR3
<400> 564
Ala Lys Asp Arg Gly Met Asp Asn Ile His Thr Gly Gln Asn Ser Gly
1 5 10 15
Trp Ser Phe Gly Trp Phe Asp Pro
20
<210> 565
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的L-CDR1
<400> 565
Ser Ser Asp Val Gly Gly Tyr Asn Tyr
1 5
<210> 566
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的L-CDR2
<400> 566
Asp Val Thr
1
<210> 567
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的L-CDR3
<400> 567
Ser Ser Tyr Ala Gly Ser Tyr Thr Ser Val
1 5 10
<210> 568
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的SCFV
<400> 568
caggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggagtc tcttagactc 60
tcctgtgaag cctctggttt cactttcgct aacgcctgga tgagttggtt ccgccaggcg 120
ccagggaagg ggctggagtg ggttggccgt atttatagca catctgatgg tggagccaca 180
gactacgctg ctcccgttga gggccgattt accatctcca gagatgactc aaaaaacacg 240
ctgtttctgc aaatg 255
<210> 569
<211> 133
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的VH2
<400> 569
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ala Asn Ala
20 25 30
Trp Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Arg Ile Tyr Ser Thr Ser Asp Gly Gly Ala Thr Asp Tyr Ala Ala
50 55 60
Pro Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65 70 75 80
Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ala Lys Asp Arg Gly Met Asp Asn Ile His Thr Gly Gln Asn
100 105 110
Ser Gly Trp Ser Phe Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu
115 120 125
Val Thr Val Ser Ser
130
<210> 570
<211> 110
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的VL2
<400> 570
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser
85 90 95
Tyr Thr Ser Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 571
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的H-FR1
<400> 571
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu
1 5 10 15
Ser Leu Arg Leu Ser Cys Glu Ala Ser
20 25
<210> 572
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的H-FR2
<400> 572
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
1 5 10 15
Arg
<210> 573
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的H-FR3
<400> 573
Asp Tyr Ala Ala Pro Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp
1 5 10 15
Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 574
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的H-FR4
<400> 574
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 575
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的L-FR1
<400> 575
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Val Thr Ile Ser Cys Thr Gly Thr
20 25
<210> 576
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的L-FR2
<400> 576
Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile
1 5 10 15
Tyr
<210> 577
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的L-FR3
<400> 577
Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln
20 25 30
Ala Glu Asp Glu
35
<210> 578
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11B10的L-FR4
<400> 578
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 579
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的H-CDR1
<400> 579
Gly Phe Thr Val Ser Asn Ala Trp
1 5
<210> 580
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的H-CDR2
<400> 580
Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr
1 5 10
<210> 581
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的H-CDR3
<400> 581
Ala Lys Asp Pro Asp Ala Glu Asn Thr Gly Ala
1 5 10
<210> 582
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的L-CDR1
<400> 582
Asp Ile Gly Ser Lys Ser
1 5
<210> 583
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的L-CDR2
<400> 583
Ser Asp Ser
1
<210> 584
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的L-CDR3
<400> 584
Gln Val Trp Asp Asn Gly Ser Asp His Pro Gly Val
1 5 10
<210> 585
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的SCFV
<400> 585
caggtgcagc tggtacagtc ggggggaggc ttggtaaagc ctggggggtc ccttagactc 60
tcctgtgcag tcagtggatt cactgtcagt aatgcctgga tgatgtggtt ccgccaggta 120
ccagggaagg ggctggagtg ggttggccgt attaaaagca aaactgatgg tgggacaaca 180
gagtacgctg cacccgtgaa aggcagattc agcatctcag gagacgactc aaaaaacaca 240
ctgtatctcc aaatg 255
<210> 586
<211> 120
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的VH2
<400> 586
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Ser Asn Ala
20 25 30
Trp Met Met Trp Phe Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Glu Tyr Ala Ala
50 55 60
Pro Val Lys Gly Arg Phe Ser Ile Ser Gly Asp Asp Ser Lys Asn Thr
65 70 75 80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ala Lys Asp Pro Asp Ala Glu Asn Thr Gly Ala Leu Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 587
<211> 109
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的VL2
<400> 587
Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Gly Ile Thr Cys Gly Gly Asp Asp Ile Gly Ser Lys Ser Val
20 25 30
His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Ser
35 40 45
Ser Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Thr Arg Val Glu Asp Gly
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Gly Ser Asp His
85 90 95
Pro Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 588
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的H-FR1
<400> 588
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Val Ser
20 25
<210> 589
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的H-FR2
<400> 589
Met Met Trp Phe Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val Gly
1 5 10 15
Arg
<210> 590
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的H-FR3
<400> 590
Glu Tyr Ala Ala Pro Val Lys Gly Arg Phe Ser Ile Ser Gly Asp Asp
1 5 10 15
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 591
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的H-FR4
<400> 591
Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 592
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的L-FR1
<400> 592
Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
1 5 10 15
Thr Ala Gly Ile Thr Cys Gly Gly Asp
20 25
<210> 593
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的L-FR2
<400> 593
Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile
1 5 10 15
Ser
<210> 594
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的L-FR3
<400> 594
Ile Ser Ser Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser
1 5 10 15
Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Thr Arg Val Glu
20 25 30
Asp Gly Asp Glu
35
<210> 595
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-11C04的L-FR4
<400> 595
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 596
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的H-CDR1
<400> 596
Gly Phe Thr Phe Thr Lys Tyr Thr
1 5
<210> 597
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的H-CDR2
<400> 597
Ile Ser Tyr Asp Gly Ser Asn Lys
1 5
<210> 598
<211> 16
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的H-CDR3
<400> 598
Thr Pro Phe Gln His Asp Ser Val Pro Arg Arg Gly Ala Phe Asp Leu
1 5 10 15
<210> 599
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的L-CDR1
<400> 599
Ser Ser Asp Val Gly Gly Tyr Asn Tyr
1 5
<210> 600
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的L-CDR2
<400> 600
Asp Val Asp
1
<210> 601
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的L-CDR3
<400> 601
Ser Ser Ser Arg Pro Ser Ser Thr Pro Arg Val
1 5 10
<210> 602
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的SCFV
<400> 602
cagatgcagc tggtggagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcact aaatatacta tgctctgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtggcactt atatcatatg atggaagcaa caaaaattac 180
gcagattccg tgaagggccg attcaccatt tcccgagacg attccaagag cacgctattt 240
ctgcaaatga gcagc 255
<210> 603
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的VH2
<400> 603
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Lys Tyr
20 25 30
Thr Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Leu Ile Ser Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Phe
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Pro Phe Gln His Asp Ser Val Pro Arg Arg Gly Ala Phe Asp Leu
100 105 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 604
<211> 111
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的VL2
<400> 604
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Ala Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Val Ile Tyr Asp Val Asp Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Ser Arg Pro Ser
85 90 95
Ser Thr Pro Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 605
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的H-FR1
<400> 605
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 606
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的H-FR2
<400> 606
Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
1 5 10 15
Leu
<210> 607
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的H-FR3
<400> 607
Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
1 5 10 15
Ser Lys Ser Thr Leu Phe Leu Gln Met Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 608
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的H-FR4
<400> 608
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
1 5 10
<210> 609
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的L-FR1
<400> 609
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Ala Ile Ser Cys Thr Gly Thr
20 25
<210> 610
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的L-FR2
<400> 610
Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Val Ile
1 5 10 15
Tyr
<210> 611
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的L-FR3
<400> 611
Ile Tyr Asp Val Asp Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser
1 5 10 15
Gly Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln
20 25 30
Ala Asp Asp Glu
35
<210> 612
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-15A01的L-FR4
<400> 612
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 613
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的H-CDR1
<400> 613
Gly Ile Ala Phe Ser Arg Tyr Ala
1 5
<210> 614
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的H-CDR2
<400> 614
Ile Gly Ser Thr Gly Thr Thr
1 5
<210> 615
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的H-CDR3
<400> 615
Ala Thr His Phe Gly Phe Phe Ser Lys
1 5
<210> 616
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的L-CDR1
<400> 616
Gln Ser Leu Leu His Arg Asn Gly Tyr Asn Tyr
1 5 10
<210> 617
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的L-CDR2
<400> 617
Leu Gly Ser
1
<210> 618
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的L-CDR3
<400> 618
Met Gln Ala Leu Glu Thr Arg Trp Thr
1 5
<210> 619
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的SCFV
<400> 619
caggtgcagc tggtggagtc tgggggagac ttggtacagc ctggggggtc cctgagactc 60
tcctgtgtag actctggaat cgcctttagc agatatgcca tgaactgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcaagt attggtagta ctggtaccac atactacgca 180
gactccgtga agggccggtt caccatctcc agagacagat ccaagaacac gctgtatctg 240
caaatgaaca gtctg 255
<210> 620
<211> 115
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的VH2
<400> 620
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Asp Ser Gly Ile Ala Phe Ser Arg Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Gly Ser Thr Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys
50 55 60
Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Asn Thr Leu Tyr Leu
65 70 75 80
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Thr His Phe Gly Phe Phe Ser Lys Trp Gly Gln Gly Thr Leu Val Thr
100 105 110
Val Ser Ser
115
<210> 621
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的VL2
<400> 621
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Arg
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Glu Thr Arg Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 622
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的H-FR1
<400> 622
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Asp Ser
20 25
<210> 623
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的H-FR2
<400> 623
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
1 5 10 15
Ser
<210> 624
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的H-FR3
<400> 624
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg
1 5 10 15
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 625
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的H-FR4
<400> 625
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 626
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的L-FR1
<400> 626
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser
20 25
<210> 627
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的L-FR2
<400> 627
Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
1 5 10 15
Tyr
<210> 628
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的L-FR3
<400> 628
Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 629
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-16E02的L-FR4
<400> 629
Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
1 5 10
<210> 630
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的H-CDR1
<400> 630
Gly Gly Thr Leu Ser Ser Tyr Pro
1 5
<210> 631
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的H-CDR2
<400> 631
Ile Asn Pro Asn Gly Gly Ala Thr
1 5
<210> 632
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的H-CDR3
<400> 632
Ala Gln Leu Gly Ser Ser Gly Gly Gly
1 5
<210> 633
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的L-CDR1
<400> 633
Ser Leu Arg Lys Tyr His
1 5
<210> 634
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的L-CDR2
<400> 634
Gly Lys Asn
1
<210> 635
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的L-CDR3
<400> 635
Asn Ser Arg Asp Ser Ser Gly Asn Asp Leu Arg Val
1 5 10
<210> 636
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的SCFV
<400> 636
caggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60
tcctgcaaga cttctggagg cactttaagc agttatccca tcacctgggt gcgacaggcc 120
cctggacaag ggcctgagtg gatgggaatt atcaacccca atggtggcgc cacaaactac 180
gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacggg cacagtctac 240
atggaactga gcagc 255
<210> 637
<211> 116
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的VH2
<400> 637
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Leu Ser Ser Tyr
20 25 30
Pro Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Ile Ile Asn Pro Asn Gly Gly Ala Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Gly Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gln Leu Gly Ser Ser Gly Gly Gly Leu Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 638
<211> 109
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的VL2
<400> 638
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Lys Tyr His Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
35 40 45
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Gly Arg Phe Ser Gly Ser
50 55 60
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Asp
85 90 95
Leu Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105
<210> 639
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的H-FR1
<400> 639
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser
20 25
<210> 640
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的H-FR2
<400> 640
Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly
1 5 10 15
Ile
<210> 641
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的H-FR3
<400> 641
Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr
1 5 10 15
Ser Thr Gly Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 642
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的H-FR4
<400> 642
Leu Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 643
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的L-FR1
<400> 643
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Gln Gly Asp
20 25
<210> 644
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的L-FR2
<400> 644
Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile
1 5 10 15
Tyr
<210> 645
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的L-FR3
<400> 645
Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Gly Arg Phe Ser
1 5 10 15
Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln
20 25 30
Ala Glu Asp Glu
35
<210> 646
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18C03的L-FR4
<400> 646
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
1 5 10
<210> 647
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的H-CDR1
<400> 647
Gly Phe Thr Phe Ser Ser Tyr Gly
1 5
<210> 648
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的H-CDR2
<400> 648
Ile Ser Tyr Asp Gly Ser Asn Lys
1 5
<210> 649
<211> 15
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的H-CDR3
<400> 649
Ala Arg Met Arg Trp Ala Val Ala Gly Met Gly Ala Phe Glu Ile
1 5 10 15
<210> 650
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的L-CDR1
<400> 650
Gln Ser Val Thr Ser Ser Tyr
1 5
<210> 651
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的L-CDR2
<400> 651
Gly Ala Ser
1
<210> 652
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的L-CDR3
<400> 652
Gln Gln Arg Ser Ser Trp Pro Pro Leu Thr
1 5 10
<210> 653
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的SCFV
<400> 653
cagatgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagc 255
<210> 654
<211> 122
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的VH2
<400> 654
Gln Met Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Met Arg Trp Ala Val Ala Gly Met Gly Ala Phe Glu Ile Trp
100 105 110
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 655
<211> 109
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的VL2
<400> 655
Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Val Leu
35 40 45
Ile Tyr Gly Ala Ser Gly Arg Ala Thr Gly Thr Pro Ala Arg Phe Ser
50 55 60
Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Trp Pro
85 90 95
Pro Leu Thr Phe Gly Pro Gly Ser Lys Val Glu Ile Lys
100 105
<210> 656
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的H-FR1
<400> 656
Gln Met Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 657
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的H-FR2
<400> 657
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
1 5 10 15
Val
<210> 658
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的H-FR3
<400> 658
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 659
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的H-FR4
<400> 659
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 660
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的L-FR1
<400> 660
Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser
20 25
<210> 661
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的L-FR2
<400> 661
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Val Leu Ile
1 5 10 15
Tyr
<210> 662
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的L-FR3
<400> 662
Ile Tyr Gly Ala Ser Gly Arg Ala Thr Gly Thr Pro Ala Arg Phe Ser
1 5 10 15
Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu
20 25 30
Pro Glu Asp Phe
35
<210> 663
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-18G02的L-FR4
<400> 663
Phe Gly Pro Gly Ser Lys Val Glu Ile Lys
1 5 10
<210> 664
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的H-CDR1
<400> 664
Gly Gly Ser Phe Arg Ser Asn Ala
1 5
<210> 665
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的H-CDR2
<400> 665
Ile Ile Pro Leu Ala Asn Arg Ser
1 5
<210> 666
<211> 13
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的H-CDR3
<400> 666
Ala Arg Leu Asp Asp Asn Val Ser Trp Gly Leu Asp Pro
1 5 10
<210> 667
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的L-CDR1
<400> 667
Gln Asp Ile Ser Arg Arg
1 5
<210> 668
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的L-CDR2
<400> 668
Ala Ala Ser
1
<210> 669
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的L-CDR3
<400> 669
Gln Gln Ser Ser Asn Val Pro Leu Thr
1 5
<210> 670
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的SCFV
<400> 670
caggtgcagc tggtgcagtc tggggctgag gtggtgaagc ccgggtcctc ggtgaaggtc 60
tcctgtaagg cttctggagg cagcttcaga agcaatgctg tcagctgggt gcgacaggcc 120
cctggacaag gtcttgagtg gataggaggc atcatccctc tggctaatag gtcagtctac 180
gcacagaagt tccagggcag actcaccatt accgcggaca aatccacggg tacagcctac 240
atggagttga gcagc 255
<210> 671
<211> 120
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的VH2
<400> 671
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Arg Ser Asn
20 25 30
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Gly Ile Ile Pro Leu Ala Asn Arg Ser Val Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Leu Thr Ile Thr Ala Asp Lys Ser Thr Gly Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Leu Asp Asp Asn Val Ser Trp Gly Leu Asp Pro Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 672
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的VL2
<400> 672
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Asn Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Arg Arg
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Ser Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ser Asn Val Pro Leu
85 90 95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105
<210> 673
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的H-FR1
<400> 673
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 674
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的H-FR2
<400> 674
Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly
1 5 10 15
Gly
<210> 675
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的H-FR3
<400> 675
Val Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Lys
1 5 10 15
Ser Thr Gly Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 676
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的H-FR4
<400> 676
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 677
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的L-FR1
<400> 677
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Asn Ile Thr Cys Arg Ala Ser
20 25
<210> 678
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的L-FR2
<400> 678
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
1 5 10 15
Ser
<210> 679
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的L-FR3
<400> 679
Ile Ser Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
20 25 30
Pro Glu Asp Phe
35
<210> 680
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20A05的L-FR4
<400> 680
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 681
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的H-CDR1
<400> 681
Gly Gly Thr Phe Ser Ser Tyr Ala
1 5
<210> 682
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的H-CDR2
<400> 682
Ile Ile Pro Ile Phe Gly Thr Ala
1 5
<210> 683
<211> 20
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的H-CDR3
<400> 683
Ala Thr Lys Gly Gly Gly Asn Ser Arg Ser Phe Leu Arg Tyr Phe Tyr
1 5 10 15
Gly Leu Asp Val
20
<210> 684
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的L-CDR1
<400> 684
Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr
1 5 10
<210> 685
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的L-CDR2
<400> 685
Lys Val Ser
1
<210> 686
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的L-CDR3
<400> 686
Met Gln Gly Thr His Trp Pro Trp Thr
1 5
<210> 687
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的SCFV
<400> 687
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60
tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac 180
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa cacagcctac 240
atggagctga gcagc 255
<210> 688
<211> 127
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的VH2
<400> 688
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Lys Gly Gly Gly Asn Ser Arg Ser Phe Leu Arg Tyr Phe Tyr
100 105 110
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 689
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的VL2
<400> 689
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ala Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
85 90 95
Thr His Trp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 690
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的H-FR1
<400> 690
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 691
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的H-FR2
<400> 691
Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Gly
<210> 692
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的H-FR3
<400> 692
Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu
1 5 10 15
Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 693
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的H-FR4
<400> 693
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 694
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的L-FR1
<400> 694
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ala Leu Gly
1 5 10 15
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser
20 25
<210> 695
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的L-FR2
<400> 695
Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile
1 5 10 15
Tyr
<210> 696
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的L-FR3
<400> 696
Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 697
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G03的L-FR4
<400> 697
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 698
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的H-CDR1
<400> 698
Gly Phe Asn Phe Asn Thr Tyr Ala
1 5
<210> 699
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的H-CDR2
<400> 699
Ile Gly Gly Gly Gly Gly Asn Thr
1 5
<210> 700
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的H-CDR3
<400> 700
Ala Thr Arg Gly Gly Trp Tyr Val Asn Asp
1 5 10
<210> 701
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的L-CDR1
<400> 701
Ser Ser Asn Ile Gly Ala Gly Tyr Ala
1 5
<210> 702
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的L-CDR2
<400> 702
Ser Asn Thr
1
<210> 703
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的L-CDR3
<400> 703
Gln Ser Tyr Asp Asn Ser Leu Ser Asp Ser Val Val
1 5 10
<210> 704
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的SCFV
<400> 704
caggtgcagc tggtggagtc tgggggaggg ttggtacagc cgggggggtc cctgagactc 60
tcctgtacag cctctggatt caactttaat acctatgcca tgagctgggt ccgccagcct 120
ccagggaagg ggctggagtg ggtctcaact attgggggtg gtggtgggaa cacattttac 180
gcagattccg tgaggggccg gttcaccatc tccagagaca attccgagaa cacgctgtat 240
ctgcaaatga acagt 255
<210> 705
<211> 117
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的VH2
<400> 705
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Phe Asn Thr Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Gly Gly Gly Gly Gly Asn Thr Phe Tyr Ala Asp Ser Val
50 55 60
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Thr Arg Gly Gly Trp Tyr Val Asn Asp Trp Gly Arg Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 706
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的VL2
<400> 706
Gln Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
20 25 30
Tyr Ala Val His Trp Tyr Gln Gln Ile Pro Gly Thr Ala Pro Lys Leu
35 40 45
Leu Ile Tyr Ser Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser
85 90 95
Leu Ser Asp Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 707
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的H-FR1
<400> 707
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser
20 25
<210> 708
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的H-FR2
<400> 708
Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val Ser
1 5 10 15
Thr
<210> 709
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的H-FR3
<400> 709
Phe Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 710
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的H-FR4
<400> 710
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 711
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的L-FR1
<400> 711
Gln Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Arg Val Thr Ile Ser Cys Thr Gly Ser
20 25
<210> 712
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的L-FR2
<400> 712
Val His Trp Tyr Gln Gln Ile Pro Gly Thr Ala Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 713
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的L-FR3
<400> 713
Ile Tyr Ser Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln
20 25 30
Ala Glu Asp Glu
35
<210> 714
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-20G12的L-FR4
<400> 714
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
1 5 10
<210> 715
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的H-CDR1
<400> 715
Gly Asp Thr Phe Ser Thr Tyr Ala
1 5
<210> 716
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的H-CDR2
<400> 716
Ile Ile Pro Arg Leu Gly Ile Ala
1 5
<210> 717
<211> 19
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的H-CDR3
<400> 717
Ala Ala Asp Pro Leu Trp Phe Gly Asp Phe Ile Arg Gly Gly Arg Ala
1 5 10 15
Phe Asn Ile
<210> 718
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的L-CDR1
<400> 718
Gln Ser Ile Ser Thr Trp
1 5
<210> 719
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的L-CDR2
<400> 719
Lys Ala Ser
1
<210> 720
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的L-CDR3
<400> 720
Gln Gln Tyr Tyr Asn Tyr Pro Tyr Thr
1 5
<210> 721
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的SCFV
<400> 721
cagatgcagc tggtgcagtc tggggctgag gtgagaaagc ctgggtcttc ggtgacggtc 60
tcctgcaagg ctcctggaga caccttcagt acttatgcta tcagttgggt gcgacaggcc 120
cctggacaag ggcttgactg gatggggagg atcatccctc gccttggtat tgcaaaaaat 180
gcaccggagt tccaggacag agtctcgatc accgcggaca aatccacgaa tacagtgcat 240
atggagttga gaaac 255
<210> 722
<211> 126
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的VH2
<400> 722
Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Thr Val Ser Cys Lys Ala Pro Gly Asp Thr Phe Ser Thr Tyr
20 25 30
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Asp Trp Met
35 40 45
Gly Arg Ile Ile Pro Arg Leu Gly Ile Ala Lys Asn Ala Pro Glu Phe
50 55 60
Gln Asp Arg Val Ser Ile Thr Ala Asp Lys Ser Thr Asn Thr Val His
65 70 75 80
Met Glu Leu Arg Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ala Asp Pro Leu Trp Phe Gly Asp Phe Ile Arg Gly Gly Arg Ala
100 105 110
Phe Asn Ile Trp Gly Gln Gly Thr Met Ile Thr Val Ser Ser
115 120 125
<210> 723
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的VL2
<400> 723
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Lys Ala Ser Thr Ile Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Asp Thr Glu Phe Thr Leu Thr Ile Thr Asn Leu Gln Pro
65 70 75 80
Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 724
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的H-FR1
<400> 724
Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Thr Val Ser Cys Lys Ala Pro
20 25
<210> 725
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的H-FR2
<400> 725
Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Asp Trp Met Gly
1 5 10 15
Arg
<210> 726
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的H-FR3
<400> 726
Lys Asn Ala Pro Glu Phe Gln Asp Arg Val Ser Ile Thr Ala Asp Lys
1 5 10 15
Ser Thr Asn Thr Val His Met Glu Leu Arg Asn Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 727
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的H-FR4
<400> 727
Trp Gly Gln Gly Thr Met Ile Thr Val Ser Ser
1 5 10
<210> 728
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的L-FR1
<400> 728
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 729
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的L-FR2
<400> 729
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 730
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的L-FR3
<400> 730
Ile Tyr Lys Ala Ser Thr Ile Glu Ser Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Asp Thr Glu Phe Thr Leu Thr Ile Thr Asn Leu Gln
20 25 30
Pro Asp Asp Ser
35
<210> 731
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21B10的L-FR4
<400> 731
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
1 5 10
<210> 732
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的H-CDR1
<400> 732
Gly Phe Thr Phe Asp Tyr Ser Ala
1 5
<210> 733
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的H-CDR2
<400> 733
Ile Ser Gly Asp Gly Gly Thr Ala
1 5
<210> 734
<211> 16
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的H-CDR3
<400> 734
Ala Arg Asp Arg Trp Arg Trp Met Asp Asp Tyr Tyr Gly Met Asp Val
1 5 10 15
<210> 735
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的L-CDR1
<400> 735
Gln Gly Ile Thr Gly Tyr
1 5
<210> 736
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的L-CDR2
<400> 736
Lys Ser Ser
1
<210> 737
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的L-CDR3
<400> 737
Gln Gln Tyr Asp Ser Tyr Pro Trp Thr
1 5
<210> 738
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的SCFV
<400> 738
cagatgcagc tggtgcagtc ggggggaacc gtggtacagc ctggggagtc cctgagactc 60
tcctgtgcaa cctctggatt cacctttgat tattctgcca tgcactgggt ccgtcaagct 120
ccagggaagg gtctggagtg ggtctctctc atcagtgggg atggtggtac cgcatattat 180
gcagactctg tgaagggccg attcaccgtc tccagagaca acagcaaaaa ctccctgtat 240
ctgcaaatga acagt 255
<210> 739
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的VH2
<400> 739
Gln Met Gln Leu Val Gln Ser Gly Gly Thr Val Val Gln Pro Gly Glu
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Asp Tyr Ser
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Ser Gly Asp Gly Gly Thr Ala Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Trp Arg Trp Met Asp Asp Tyr Tyr Gly Met Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 740
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的VL2
<400> 740
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Thr Gly Tyr
20 25 30
Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Leu
35 40 45
Tyr Lys Ser Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Ala
65 70 75 80
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Trp
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 741
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的H-FR1
<400> 741
Gln Met Gln Leu Val Gln Ser Gly Gly Thr Val Val Gln Pro Gly Glu
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Thr Ser
20 25
<210> 742
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的H-FR2
<400> 742
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
1 5 10 15
Leu
<210> 743
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的H-FR3
<400> 743
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 744
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的H-FR4
<400> 744
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 745
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的L-FR1
<400> 745
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 746
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的L-FR2
<400> 746
Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Leu
1 5 10 15
Tyr
<210> 747
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的L-FR3
<400> 747
Leu Tyr Lys Ser Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln
20 25 30
Ala Asp Asp Phe
35
<210> 748
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21F02的L-FR4
<400> 748
Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
1 5 10
<210> 749
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的H-CDR1
<400> 749
Gly Phe Thr Phe Asn Phe Tyr Gly
1 5
<210> 750
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的H-CDR2
<400> 750
Ile Ser Tyr Glu Gly Ser Lys Lys
1 5
<210> 751
<211> 20
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的H-CDR3
<400> 751
Ala Arg Gly Phe Asp Pro Asp Tyr Leu Arg Gly Asn Asn Arg Tyr Phe
1 5 10 15
Gly Leu Asp Val
20
<210> 752
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的L-CDR1
<400> 752
Glu Asp Ile Ser Arg Gln
1 5
<210> 753
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的L-CDR2
<400> 753
Gly Ala Ser
1
<210> 754
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的L-CDR3
<400> 754
Gln Lys Ala Asn Asn Phe Pro Tyr Thr
1 5
<210> 755
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的SCFV
<400> 755
caggtgcagc tggtggagtc tgggggaggt gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcaat ttctatggta tgcactgggt ccgccaggct 120
ccaggtaagg ggctagagtg gctggcagct atatcatatg aaggaagtaa gaagtactac 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgccggat 240
ctgcaaatga acagt 255
<210> 756
<211> 127
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的VH2
<400> 756
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Phe Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu
35 40 45
Ala Ala Ile Ser Tyr Glu Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Pro Asp
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Gly Phe Asp Pro Asp Tyr Leu Arg Gly Asn Asn Arg Tyr Phe
100 105 110
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120 125
<210> 757
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的VL2
<400> 757
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Ser Arg Gln
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Phe Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Lys Ala Asn Asn Phe Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
100 105
<210> 758
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的H-FR1
<400> 758
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 759
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的H-FR2
<400> 759
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Ala
1 5 10 15
Ala
<210> 760
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的H-FR3
<400> 760
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Thr Pro Asp Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 761
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的H-FR4
<400> 761
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 762
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的L-FR1
<400> 762
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 763
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的L-FR2
<400> 763
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 764
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的L-FR3
<400> 764
Ile Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Phe Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln
20 25 30
Pro Glu Asp Phe
35
<210> 765
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-21H04的L-FR4
<400> 765
Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
1 5 10
<210> 766
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的H-CDR1
<400> 766
Gly Phe Met Phe Lys Asn Tyr Ala
1 5
<210> 767
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的H-CDR2
<400> 767
Val Ser Gly Ser Gly Asp Thr Thr
1 5
<210> 768
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的H-CDR3
<400> 768
Ala Lys Val Gly Val Ala Val Ala Gln Gly Asp Tyr
1 5 10
<210> 769
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的L-CDR1
<400> 769
Gln Ser Val Leu Ser Ser Ser Asn Asn Lys Asn Tyr
1 5 10
<210> 770
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的L-CDR2
<400> 770
Trp Ala Ser
1
<210> 771
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的L-CDR3
<400> 771
Gln Gln Tyr Tyr Gly Thr Pro Leu Thr
1 5
<210> 772
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的SCFV
<400> 772
cagatgcagc tggtggagtc ggggggaggc ttcgtacagc ctggggggtc ccggagactc 60
tcctgtgcag gctctggatt catgtttaag aattatgcca tgacttggtt tcgccaggct 120
ccagggaagg ggctggagtg ggtctcagct gtcagtggtt ctggtgacac cacatactac 180
acagactccg tgaagggccg gttcatcatc tccagagaca attccaacaa caccgtctat 240
ctgcaaatga acagt 255
<210> 773
<211> 119
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的VH2
<400> 773
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly
1 5 10 15
Ser Arg Arg Leu Ser Cys Ala Gly Ser Gly Phe Met Phe Lys Asn Tyr
20 25 30
Ala Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Val Ser Gly Ser Gly Asp Thr Thr Tyr Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Asn Asn Thr Val Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val Gly Val Ala Val Ala Gln Gly Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 774
<211> 113
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的VL2
<400> 774
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Ser Ser
20 25 30
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
85 90 95
Tyr Tyr Gly Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 775
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的H-FR1
<400> 775
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly
1 5 10 15
Ser Arg Arg Leu Ser Cys Ala Gly Ser
20 25
<210> 776
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的H-FR2
<400> 776
Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
1 5 10 15
Ala
<210> 777
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的H-FR3
<400> 777
Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn
1 5 10 15
Ser Asn Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 778
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的H-FR4
<400> 778
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 779
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的L-FR1
<400> 779
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser
20 25
<210> 780
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的L-FR2
<400> 780
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile
1 5 10 15
Tyr
<210> 781
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的L-FR3
<400> 781
Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
20 25 30
Ala Glu Asp Val
35
<210> 782
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-22G10的L-FR4
<400> 782
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 783
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的H-CDR1
<400> 783
Arg Tyr Thr Phe Thr Tyr Arg Tyr
1 5
<210> 784
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的H-CDR2
<400> 784
Ile Gln Pro Phe Asn Gly Asn Thr
1 5
<210> 785
<211> 16
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的H-CDR3
<400> 785
Ala Lys Asp Ile Arg Ile Glu Asp Ile Val Val Val Pro Ala Ala Ile
1 5 10 15
<210> 786
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的L-CDR1
<400> 786
Ser Ser Asp Val Gly Gly Tyr Asn Tyr
1 5
<210> 787
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的L-CDR2
<400> 787
Glu Val Asn
1
<210> 788
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的L-CDR3
<400> 788
Ser Ser Tyr Thr Ser Ser Ser Thr Phe Asp
1 5 10
<210> 789
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的SCFV
<400> 789
caggtgcagc tggtgcagtc tggggctgag gtgaagaaga ctgggtcctc agtgaaagtt 60
tcctgcaaga cttccagata caccttcacc taccgttatc tgcactgggt gcgacaggcc 120
cccggacaag cgcttgagtg gttggggtgg atccaacctt tcaatggtaa taccaactac 180
gcacagaaat tccaagacag agtcaccatt acccgggaca ggtctatgag cacagcctac 240
atggagctga gcagc 255
<210> 790
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的VH2
<400> 790
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Thr Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe Thr Tyr Arg
20 25 30
Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Leu
35 40 45
Gly Trp Ile Gln Pro Phe Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Arg Asp Arg Ser Met Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Ile Arg Ile Glu Asp Ile Val Val Val Pro Ala Ala Ile
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 791
<211> 110
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的VL2
<400> 791
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
35 40 45
Met Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
85 90 95
Ser Thr Phe Asp Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 792
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的H-FR1
<400> 792
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Thr Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Thr Ser
20 25
<210> 793
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的H-FR2
<400> 793
Leu His Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Leu Gly
1 5 10 15
Trp
<210> 794
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的H-FR3
<400> 794
Asn Tyr Ala Gln Lys Phe Gln Asp Arg Val Thr Ile Thr Arg Asp Arg
1 5 10 15
Ser Met Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 795
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的H-FR4
<400> 795
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 796
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的L-FR1
<400> 796
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Thr
20 25
<210> 797
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的L-FR2
<400> 797
Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile
1 5 10 15
Tyr
<210> 798
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的L-FR3
<400> 798
Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser
1 5 10 15
Gly Ser Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu Gln
20 25 30
Ser Glu Asp Glu
35
<210> 799
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-24A05的L-FR4
<400> 799
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 800
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的H-CDR1
<400> 800
Gly Phe Thr Phe Lys Thr Tyr Ser
1 5
<210> 801
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的H-CDR2
<400> 801
Ile Asn Asn Asn Gly Asp Ala Thr
1 5
<210> 802
<211> 28
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的H-CDR3
<400> 802
Ala Arg Asp Leu Ile Ala His Glu Gln Pro Lys Phe Ser Leu Arg Tyr
1 5 10 15
Phe Asp Trp Leu Ser Ser Arg Lys Gly Met Asp Val
20 25
<210> 803
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的L-CDR1
<400> 803
Ser Ser Asp Val Gly Gly Tyr Asn Tyr
1 5
<210> 804
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的L-CDR2
<400> 804
Asp Val Thr
1
<210> 805
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的L-CDR3
<400> 805
Ser Ser Tyr Ser Ser Ser Thr Phe Tyr Val
1 5 10
<210> 806
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的SCFV
<400> 806
caggtgcagc tggtgcagtc tgggggaggc ttggtccagc ctggggggtc cctgaaactc 60
tcctgttcag cctctggatt caccttcaaa acctattcta tgcactgggt ccgccaggct 120
ccggggaagg gactggaata tgtttcagct attaataata atggggatgc cacatactac 180
gcagactccg tgaagggcag attcaccatc tccagagaca attccaagga cacgctgtat 240
cttcaaatga acagt 255
<210> 807
<211> 135
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的VH2
<400> 807
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Lys Thr Tyr
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val
35 40 45
Ser Ala Ile Asn Asn Asn Gly Asp Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Ile Ala His Glu Gln Pro Lys Phe Ser Leu Arg Tyr
100 105 110
Phe Asp Trp Leu Ser Ser Arg Lys Gly Met Asp Val Trp Gly Gln Gly
115 120 125
Thr Thr Ile Thr Val Ser Ser
130 135
<210> 808
<211> 110
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的VL2
<400> 808
Asn Phe Met Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Gly Tyr
20 25 30
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Gln Leu
35 40 45
Ile Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
50 55 60
Ser Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu
65 70 75 80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ser Ser Ser
85 90 95
Thr Phe Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105 110
<210> 809
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的H-FR1
<400> 809
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ser Ala Ser
20 25
<210> 810
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的H-FR2
<400> 810
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Ser
1 5 10 15
Ala
<210> 811
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的H-FR3
<400> 811
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asp Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 812
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的H-FR4
<400> 812
Trp Gly Gln Gly Thr Thr Ile Thr Val Ser Ser
1 5 10
<210> 813
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的L-FR1
<400> 813
Asn Phe Met Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
1 5 10 15
Ser Ile Thr Ile Ser Cys Thr Gly Ser
20 25
<210> 814
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的L-FR2
<400> 814
Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Gln Leu Ile Ile
1 5 10 15
Tyr
<210> 815
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的L-FR3
<400> 815
Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser
1 5 10 15
Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln
20 25 30
Ala Glu Asp Glu
35
<210> 816
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-30H01的L-FR4
<400> 816
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 817
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的H-CDR1
<400> 817
Ser Gly Phe Lys Phe Glu Asp His Ala
1 5
<210> 818
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的H-CDR2
<400> 818
Ile Ser Gly Asn Gly Asp Asp Thr
1 5
<210> 819
<211> 5
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的H-CDR3
<400> 819
Val Thr Arg Gly Ala
1 5
<210> 820
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的L-CDR1
<400> 820
Gln Ser Val Gly Thr Trp
1 5
<210> 821
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的L-CDR2
<400> 821
Ala Ala Ser
1
<210> 822
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的L-CDR3
<400> 822
Gln Gln Ala Asp Ser Phe His Ser
1 5
<210> 823
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的SCFV
<400> 823
cagatgcagc tggtggagtc agggggaggc gtggtacagc ctggggggtc cctaagactc 60
gcctgtgtag gctctggatt caagtttgaa gatcatgcca tacactgggt ccgtcaacgt 120
ccagggaagg gtctggagtg ggtcgccgtt ataagtggca atggcgatga cacatactat 180
gcagactctg cgaagggccg attcaccatt tccagagaca acagcaaaaa ctccctgtat 240
ctgcaaatga acagt 255
<210> 824
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的VH2
<400> 824
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ala Cys Val Gly Ser Gly Phe Lys Phe Glu Asp His
20 25 30
Ala Ile His Trp Val Arg Gln Arg Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Gly Asn Gly Asp Asp Thr Tyr Tyr Ala Asp Ser Ala
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Thr Arg Gly Ala Gln Gly Arg Gly Thr Leu Val Thr Val Ser Ser
100 105 110
<210> 825
<211> 106
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的VL2
<400> 825
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Gly Thr Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile
35 40 45
Ser Ala Ala Ser Ser Leu His Pro Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Phe His Ser
85 90 95
Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105
<210> 826
<211> 24
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的H-FR1
<400> 826
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ala Cys Val Gly
20
<210> 827
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的H-FR2
<400> 827
Ile His Trp Val Arg Gln Arg Pro Gly Lys Gly Leu Glu Trp Val Ala
1 5 10 15
Val
<210> 828
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的H-FR3
<400> 828
Tyr Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 829
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的H-FR4
<400> 829
Gln Gly Arg Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 830
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的L-FR1
<400> 830
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 831
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的L-FR2
<400> 831
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile
1 5 10 15
Ser
<210> 832
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的L-FR3
<400> 832
Ile Ser Ala Ala Ser Ser Leu His Pro Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
20 25 30
Pro Glu Asp Ile
35
<210> 833
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-32H08的L-FR4
<400> 833
Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
1 5 10
<210> 834
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的H-CDR1
<400> 834
Gly Asp Thr Phe Arg Lys Phe Thr
1 5
<210> 835
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的H-CDR2
<400> 835
Leu Ile Pro Ile Phe Gly Thr Pro
1 5
<210> 836
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的H-CDR3
<400> 836
Val Arg Glu Asn Tyr Glu Phe Leu Thr Gly Ala Thr Arg Tyr Phe Asp
1 5 10 15
Leu
<210> 837
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的L-CDR1
<400> 837
Ser Ser Asn Leu Gly Ala Pro Asn Asp
1 5
<210> 838
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的L-CDR2
<400> 838
Gly Ser Thr
1
<210> 839
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的L-CDR3
<400> 839
Gln Ser Tyr Asp Asn Arg Leu Ser Gly Phe Val Val
1 5 10
<210> 840
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的SCFV
<400> 840
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggttacggtc 60
tcctgcaagg cctctggaga caccttcagg aagtttactt tcaactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaggg ctcatcccga tctttggtac acctaaatac 180
tcacagaagt tccaggacag attcacaata accgcggacg aatcaacgag cacagcctac 240
atggagctac gtcgc 255
<210> 841
<211> 124
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的VH2
<400> 841
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Thr Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Arg Lys Phe
20 25 30
Thr Phe Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Leu Ile Pro Ile Phe Gly Thr Pro Lys Tyr Ser Gln Lys Phe
50 55 60
Gln Asp Arg Phe Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Arg Arg Leu Gly Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Arg Glu Asn Tyr Glu Phe Leu Thr Gly Ala Thr Arg Tyr Phe Asp
100 105 110
Leu Trp Gly Arg Gly Thr Leu Ile Thr Val Ser Ser
115 120
<210> 842
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的VL2
<400> 842
Gln Phe Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Gly Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Leu Gly Ala Pro
20 25 30
Asn Asp Val His Trp Tyr Gln Gln Arg Pro Gly Thr Ala Pro Arg Leu
35 40 45
Leu Ile Tyr Gly Ser Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
50 55 60
Ser Gly Ser Met Ser Gly Ala Ser Ala Ser Leu Ala Ile Thr Gly Leu
65 70 75 80
Leu Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Arg
85 90 95
Leu Ser Gly Phe Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 843
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的H-FR1
<400> 843
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Thr Val Ser Cys Lys Ala Ser
20 25
<210> 844
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的H-FR2
<400> 844
Phe Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Gly
<210> 845
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的H-FR3
<400> 845
Lys Tyr Ser Gln Lys Phe Gln Asp Arg Phe Thr Ile Thr Ala Asp Glu
1 5 10 15
Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Arg Leu Gly Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 846
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的H-FR4
<400> 846
Trp Gly Arg Gly Thr Leu Ile Thr Val Ser Ser
1 5 10
<210> 847
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的L-FR1
<400> 847
Gln Phe Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
1 5 10 15
Gly Val Thr Ile Ser Cys Thr Gly Ser
20 25
<210> 848
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的L-FR2
<400> 848
Val His Trp Tyr Gln Gln Arg Pro Gly Thr Ala Pro Arg Leu Leu Ile
1 5 10 15
Tyr
<210> 849
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的L-FR3
<400> 849
Ile Tyr Gly Ser Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Met Ser Gly Ala Ser Ala Ser Leu Ala Ile Thr Gly Leu Leu
20 25 30
Pro Glu Asp Glu
35
<210> 850
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35A06的L-FR4
<400> 850
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
1 5 10
<210> 851
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的H-CDR1
<400> 851
Gly Asp Thr Phe Ser Ser Tyr Ala
1 5
<210> 852
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的H-CDR2
<400> 852
Thr Ile Pro Arg Leu Gly Ala Thr
1 5
<210> 853
<211> 19
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的H-CDR3
<400> 853
Ala Arg Tyr Ile Pro Leu Val Arg Gly Val Arg Gln Pro Arg Asp Asp
1 5 10 15
Phe Glu Ile
<210> 854
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的L-CDR1
<400> 854
Gln Ser Val Ser Ser Ser Tyr
1 5
<210> 855
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的L-CDR2
<400> 855
Gly Ala Ser
1
<210> 856
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的L-CDR3
<400> 856
Gln His Arg Lys Ser Trp Pro Pro Gly Ala Thr
1 5 10
<210> 857
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的SCFV
<400> 857
cagatgcagc tggtgcagtc tggggctgag gtgaggaagc ctgggtcctc ggtgaaggtc 60
tcctgcaagg cttctggaga caccttcagc agctatgctg tcagctgggt gcgacaggcc 120
cctggactag ggcttgaatg gatgggaagg accatccctc gccttggggc aacaagctac 180
gcacagaact tccagggcag agtctcgatc actgcggaca aatccacgaa tacagtgtac 240
atggaactga gtggg 255
<210> 858
<211> 126
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的VH2
<400> 858
Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Tyr
20 25 30
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Leu Gly Leu Glu Trp Met
35 40 45
Gly Arg Thr Ile Pro Arg Leu Gly Ala Thr Ser Tyr Ala Gln Asn Phe
50 55 60
Gln Gly Arg Val Ser Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr
65 70 75 80
Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Tyr Ile Pro Leu Val Arg Gly Val Arg Gln Pro Arg Asp Asp
100 105 110
Phe Glu Ile Trp Gly Pro Gly Thr Met Ile Thr Val Ser Ser
115 120 125
<210> 859
<211> 110
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的VL2
<400> 859
Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Lys Ser Trp Pro
85 90 95
Pro Gly Ala Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
100 105 110
<210> 860
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的H-FR1
<400> 860
Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 861
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的H-FR2
<400> 861
Val Ser Trp Val Arg Gln Ala Pro Gly Leu Gly Leu Glu Trp Met Gly
1 5 10 15
Arg
<210> 862
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的H-FR3
<400> 862
Ser Tyr Ala Gln Asn Phe Gln Gly Arg Val Ser Ile Thr Ala Asp Lys
1 5 10 15
Ser Thr Asn Thr Val Tyr Met Glu Leu Ser Gly Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 863
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的H-FR4
<400> 863
Trp Gly Pro Gly Thr Met Ile Thr Val Ser Ser
1 5 10
<210> 864
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的L-FR1
<400> 864
Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
20 25
<210> 865
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的L-FR2
<400> 865
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
1 5 10 15
Tyr
<210> 866
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的L-FR3
<400> 866
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu
20 25 30
Pro Glu Asp Phe
35
<210> 867
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-35G07的L-FR4
<400> 867
Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
1 5 10
<210> 868
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的H-CDR1
<400> 868
Gly Gly Asn Phe Asn Ala Tyr Ala
1 5
<210> 869
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的H-CDR2
<400> 869
Ile Ile Pro Phe Phe Gly Ser Pro
1 5
<210> 870
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的H-CDR3
<400> 870
Thr Arg Ser Arg Asp Tyr Gly Met Asp Val
1 5 10
<210> 871
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的L-CDR1
<400> 871
Gln Ser Leu Val Asp Asn Asp Gly Asn Thr Tyr
1 5 10
<210> 872
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的L-CDR2
<400> 872
Arg Val Ser
1
<210> 873
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的L-CDR3
<400> 873
Met Gln Thr Thr His Trp Pro Pro Leu
1 5
<210> 874
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的SCFV
<400> 874
caggtgcagc tggtacagtc tggggctgag gtgaggaggc ctgggtcctc ggttaaggtc 60
tcctgcgaga cttctggagg caacttcaac gcctatgcga tcaactgggt gcgacaggcc 120
cctggacagg ggcttgaatg gatgggagga atcatccctt tctttggttc gccaaactac 180
gcacagaggt tccagggcag actcacgatc accgcggacg aatctacgag gacaacctac 240
atggaattga gcagt 255
<210> 875
<211> 117
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的VH2
<400> 875
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Arg Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Glu Thr Ser Gly Gly Asn Phe Asn Ala Tyr
20 25 30
Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Gly Ile Ile Pro Phe Phe Gly Ser Pro Asn Tyr Ala Gln Arg Phe
50 55 60
Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Thr Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Arg Ser Arg Asp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr
100 105 110
Ile Thr Val Ser Ser
115
<210> 876
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的VL2
<400> 876
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ile Leu Gly
1 5 10 15
Gln Pro Ala Ser Val Ser Cys Arg Ser Ser Gln Ser Leu Val Asp Asn
20 25 30
Asp Gly Asn Thr Tyr Leu His Trp Phe Gln Gln Arg Pro Gly Gln Ser
35 40 45
Pro Arg Arg Leu Ile Tyr Arg Val Ser Asn Arg Asp Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr
85 90 95
Thr His Trp Pro Pro Leu Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 877
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的H-FR1
<400> 877
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Arg Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Glu Thr Ser
20 25
<210> 878
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的H-FR2
<400> 878
Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
1 5 10 15
Gly
<210> 879
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的H-FR3
<400> 879
Asn Tyr Ala Gln Arg Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu
1 5 10 15
Ser Thr Arg Thr Thr Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 880
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的H-FR4
<400> 880
Trp Gly Gln Gly Thr Thr Ile Thr Val Ser Ser
1 5 10
<210> 881
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的L-FR1
<400> 881
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ile Leu Gly
1 5 10 15
Gln Pro Ala Ser Val Ser Cys Arg Ser Ser
20 25
<210> 882
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的L-FR2
<400> 882
Leu His Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile
1 5 10 15
Tyr
<210> 883
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的L-FR3
<400> 883
Ile Tyr Arg Val Ser Asn Arg Asp Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 884
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-36B11的L-FR4
<400> 884
Phe Gly Gly Gly Thr Lys Val Asp Ile Lys
1 5 10
<210> 885
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的H-CDR1
<400> 885
Gly Gly Ser Ile Ser Ser His Tyr
1 5
<210> 886
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的H-CDR2
<400> 886
Ile Ser Asn Ser Gly Asn Thr
1 5
<210> 887
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的H-CDR3
<400> 887
Ala Ser Gln Arg Ser Asp Gly Ser Leu Asp Tyr
1 5 10
<210> 888
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的L-CDR1
<400> 888
Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr
1 5 10
<210> 889
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的L-CDR2
<400> 889
Glu Val Ser
1
<210> 890
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的L-CDR3
<400> 890
Met Gln Arg Ile Glu Phe Pro Tyr Thr
1 5
<210> 891
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的SCFV
<400> 891
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctccggtgg ctccatcagt agtcactact ggagctgggt ccggcagccc 120
ccagggaaga gaccggagtg gattgggtac atctctaaca gtgggaacac gatctacaac 180
ccctccctca agagtcgagt caccatatca ttaaacacgt ccaggaacca attctccctg 240
cagctgaggt ctgtg 255
<210> 892
<211> 117
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的VH2
<400> 892
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser His
20 25 30
Tyr Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Arg Pro Glu Trp Ile
35 40 45
Gly Tyr Ile Ser Asn Ser Gly Asn Thr Ile Tyr Asn Pro Ser Leu Lys
50 55 60
Ser Arg Val Thr Ile Ser Leu Asn Thr Ser Arg Asn Gln Phe Ser Leu
65 70 75 80
Gln Leu Arg Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr Cys Ala
85 90 95
Ser Gln Arg Ser Asp Gly Ser Leu Asp Tyr Arg Gly Pro Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 893
<211> 113
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的VL2
<400> 893
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Ala Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser
20 25 30
Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln
35 40 45
Pro Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys
65 70 75 80
Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln
85 90 95
Arg Ile Glu Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
100 105 110
Lys
<210> 894
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的H-FR1
<400> 894
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Thr Val Ser
20 25
<210> 895
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的H-FR2
<400> 895
Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Arg Pro Glu Trp Ile Gly
1 5 10 15
Tyr
<210> 896
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的H-FR3
<400> 896
Ile Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Leu Asn Thr
1 5 10 15
Ser Arg Asn Gln Phe Ser Leu Gln Leu Arg Ser Val Thr Ala Val Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 897
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的H-FR4
<400> 897
Arg Gly Pro Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 898
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的L-FR1
<400> 898
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Ala Ala Ser Ile Ser Cys Arg Ser Ser
20 25
<210> 899
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的L-FR2
<400> 899
Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile
1 5 10 15
Tyr
<210> 900
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的L-FR3
<400> 900
Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 901
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-41C01的L-FR4
<400> 901
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 902
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的H-CDR1
<400> 902
Gly Asp Thr Phe Ser Arg Tyr Ala
1 5
<210> 903
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的H-CDR2
<400> 903
Ile Ile Pro Val Leu Gly Ala Ala
1 5
<210> 904
<211> 16
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的H-CDR3
<400> 904
Ala Arg Asp Leu Val Arg Gly Val Thr Pro His Tyr Gly Met Asp Val
1 5 10 15
<210> 905
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的L-CDR1
<400> 905
Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr
1 5 10
<210> 906
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的L-CDR2
<400> 906
Leu Gly Ser
1
<210> 907
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的L-CDR3
<400> 907
Met Gln Ala Arg Gln Thr Pro Leu Thr
1 5
<210> 908
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的SCFV
<400> 908
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60
tcctgcaagg cttctggaga cacgttcagc agatatgcta tcagctggat ccgacaggcc 120
cctggacaag ggcctgagtg gatgggaagg atcatccctg tccttggtgc agcaaattat 180
gcacggaagt tccaggacag agtcacgatc acagcggaca aatccacgac tacagcctac 240
atggaactga ccagt 255
<210> 909
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的VH2
<400> 909
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Arg Tyr
20 25 30
Ala Ile Ser Trp Ile Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met
35 40 45
Gly Arg Ile Ile Pro Val Leu Gly Ala Ala Asn Tyr Ala Arg Lys Phe
50 55 60
Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Thr Thr Ala Tyr
65 70 75 80
Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Leu Val Arg Gly Val Thr Pro His Tyr Gly Met Asp Val
100 105 110
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
115 120
<210> 910
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的VL2
<400> 910
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Ser Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Arg Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 911
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的H-FR1
<400> 911
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser
20 25
<210> 912
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的H-FR2
<400> 912
Ile Ser Trp Ile Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly
1 5 10 15
Arg
<210> 913
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的H-FR3
<400> 913
Asn Tyr Ala Arg Lys Phe Gln Asp Arg Val Thr Ile Thr Ala Asp Lys
1 5 10 15
Ser Thr Thr Thr Ala Tyr Met Glu Leu Thr Ser Leu Arg Ser Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 914
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的H-FR4
<400> 914
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
1 5 10
<210> 915
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的L-FR1
<400> 915
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser
20 25
<210> 916
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的L-FR2
<400> 916
Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
1 5 10 15
Tyr
<210> 917
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的L-FR3
<400> 917
Ile Tyr Leu Gly Ser Ser Arg Ala Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 918
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-42H07的L-FR4
<400> 918
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 919
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的H-CDR1
<400> 919
Gly Phe Thr Phe Ser Ser Tyr Ala
1 5
<210> 920
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的H-CDR2
<400> 920
Ile Ser Tyr Asp Gly Ser Asn Lys
1 5
<210> 921
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的H-CDR3
<400> 921
Ala Lys Asp Leu Trp Gly Arg Val Gly Ala Leu Val Gly Ala Leu Asp
1 5 10 15
Leu
<210> 922
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的L-CDR1
<400> 922
Asn Leu Arg Thr Lys Tyr
1 5
<210> 923
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的L-CDR2
<400> 923
Gln Asp Thr
1
<210> 924
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的L-CDR3
<400> 924
Gln Ala Trp Asp Ser Gly Asn Tyr Val
1 5
<210> 925
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的SCFV
<400> 925
caggtgcagc tggtggagtc tgggggaggt gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactac 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagt 255
<210> 926
<211> 124
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的VH2
<400> 926
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Leu Trp Gly Arg Val Gly Ala Leu Val Gly Ala Leu Asp
100 105 110
Leu Trp Gly Gln Gly Thr Met Ile Thr Val Ser Ser
115 120
<210> 927
<211> 106
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的VL2
<400> 927
Ser Tyr Glu Leu Thr Gln Gly Pro Ser Leu Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Asn Ile Ile Cys Ser Gly Asp Asn Leu Arg Thr Lys Tyr Val
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Ile Leu Val Ile Tyr
35 40 45
Gln Asp Thr Arg Arg Pro Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser
50 55 60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65 70 75 80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Gly Asn Tyr Val
85 90 95
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
100 105
<210> 928
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的H-FR1
<400> 928
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 929
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的H-FR2
<400> 929
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala
1 5 10 15
Val
<210> 930
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的H-FR3
<400> 930
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 931
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的H-FR4
<400> 931
Trp Gly Gln Gly Thr Met Ile Thr Val Ser Ser
1 5 10
<210> 932
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的L-FR1
<400> 932
Ser Tyr Glu Leu Thr Gln Gly Pro Ser Leu Ser Val Ser Pro Gly Gln
1 5 10 15
Thr Ala Asn Ile Ile Cys Ser Gly Asp
20 25
<210> 933
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的L-FR2
<400> 933
Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Ile Leu Val Ile
1 5 10 15
Tyr
<210> 934
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的L-FR3
<400> 934
Ile Tyr Gln Asp Thr Arg Arg Pro Ser Gly Ile Pro Ala Arg Phe Ser
1 5 10 15
Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln
20 25 30
Ala Met Asp Glu
35
<210> 935
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-44G01的L-FR4
<400> 935
Phe Gly Thr Gly Thr Lys Val Thr Val Leu
1 5 10
<210> 936
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的H-CDR1
<400> 936
Gly Phe Ile Phe Ser Asp Ser Pro
1 5
<210> 937
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的H-CDR2
<400> 937
Ile Gly Thr Thr Ala Ser Thr Tyr Ala Thr
1 5 10
<210> 938
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的H-CDR3
<400> 938
Ala Arg Asp Arg Ser Gly Trp Ser Arg Asp Tyr
1 5 10
<210> 939
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的L-CDR1
<400> 939
Gln Gly Ile Gly Arg Ser
1 5
<210> 940
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的L-CDR2
<400> 940
Ala Ala Ser
1
<210> 941
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的L-CDR3
<400> 941
Gln Gln Val Tyr Ser Tyr Pro Tyr Ser
1 5
<210> 942
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的SCFV
<400> 942
caggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgaaactc 60
tcctgtgcag cctctgggtt catcttcagt gactctccta tgcactgggt ccgccaggct 120
tccgggaaag gcctggagtg ggttggccgc attggaacca cagcttccac ttacgcgaca 180
gtatatgctg cgtcggtgaa aggcaggttc accatctcca gagatgactc aaagaacacg 240
gcttatctgc aaatg 255
<210> 943
<211> 120
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的VH2
<400> 943
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Ser
20 25 30
Pro Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Arg Ile Gly Thr Thr Ala Ser Thr Tyr Ala Thr Val Tyr Ala Ala
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65 70 75 80
Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ala Arg Asp Arg Ser Gly Trp Ser Arg Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 944
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的VL2
<400> 944
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Arg Ser
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Thr Val Leu Ile
35 40 45
Tyr Ala Ala Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ala Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Arg Leu Leu Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Ser Tyr Pro Tyr
85 90 95
Ser Phe Gly Leu Gly Thr Met Leu Glu Ile Lys
100 105
<210> 945
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的H-FR1
<400> 945
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser
20 25
<210> 946
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的H-FR2
<400> 946
Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val Gly
1 5 10 15
Arg
<210> 947
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的H-FR3
<400> 947
Val Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
1 5 10 15
Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 948
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的H-FR4
<400> 948
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 949
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的L-FR1
<400> 949
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 950
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的L-FR2
<400> 950
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Thr Val Leu Ile
1 5 10 15
Tyr
<210> 951
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的L-FR3
<400> 951
Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ala Gly Ser Gly
1 5 10 15
Thr Asp Phe Ala Leu Thr Ile Ser Arg Leu Leu Pro Glu Asp Phe Ala
20 25 30
Thr Tyr Tyr Cys
35
<210> 952
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-46A07的L-FR4
<400> 952
Phe Gly Leu Gly Thr Met Leu Glu Ile Lys
1 5 10
<210> 953
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的H-CDR1
<400> 953
Gly Phe Thr Phe Asp Asp Tyr Ala
1 5
<210> 954
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的H-CDR2
<400> 954
Ile Ser Gly Asp Gly Gly Ser Thr
1 5
<210> 955
<211> 16
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的H-CDR3
<400> 955
Ala Arg Val Phe Gln Tyr Tyr Gly Leu Pro Arg Gly Ala Phe Asp Ile
1 5 10 15
<210> 956
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的L-CDR1
<400> 956
Gln Val Ile Asn Asn Tyr
1 5
<210> 957
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的L-CDR2
<400> 957
Ala Ala Ser
1
<210> 958
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的L-CDR3
<400> 958
Leu Gln His Lys Ser Tyr Pro Leu Thr
1 5
<210> 959
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的SCFV
<400> 959
caggtgcagc tggtgcagtc tgggggaggt gtggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagct 120
ccagggaagg gtctggagtg ggtctctctt attagtgggg atggtggtag cacatactat 180
gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa ctccctgtat 240
ctgcaaatga acagt 255
<210> 960
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的VH2
<400> 960
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Leu Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Phe Gln Tyr Tyr Gly Leu Pro Arg Gly Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Met Ile Thr Val Ser Ser
115 120
<210> 961
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的VL2
<400> 961
Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Ile Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Val Ile Asn Asn Tyr
20 25 30
Leu Ile Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Arg Leu Ile
35 40 45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Lys Ser Tyr Pro Leu
85 90 95
Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105
<210> 962
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的H-FR1
<400> 962
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 963
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的H-FR2
<400> 963
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
1 5 10 15
Leu
<210> 964
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的H-FR3
<400> 964
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 965
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的H-FR4
<400> 965
Trp Gly Gln Gly Thr Met Ile Thr Val Ser Ser
1 5 10
<210> 966
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的L-FR1
<400> 966
Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Ile Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 967
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的L-FR2
<400> 967
Leu Ile Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Arg Leu Ile
1 5 10 15
Tyr
<210> 968
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的L-FR3
<400> 968
Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln
20 25 30
Pro Glu Asp Phe
35
<210> 969
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A09的L-FR4
<400> 969
Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 970
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的H-CDR1
<400> 970
Gly Phe Ser Leu Ser Asn Ala Arg Met Gly
1 5 10
<210> 971
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的H-CDR2
<400> 971
Ile Phe Ser Ser Asp Glu Lys
1 5
<210> 972
<211> 15
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的H-CDR3
<400> 972
Ala Arg Thr Ser Arg Ile Ser Pro Thr Gly Glu Ala Phe Asp Ile
1 5 10 15
<210> 973
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的L-CDR1
<400> 973
Gln Asn Ile Gly Ser Ile
1 5
<210> 974
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的L-CDR2
<400> 974
Tyr Ala Ser
1
<210> 975
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的L-CDR3
<400> 975
His Gln Ser Arg Ser Leu Pro Gln Thr
1 5
<210> 976
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的SCFV
<400> 976
caggtcacct tgagggagtc tggtcctgtg ctggtgaaac ccacagagac cctcacgctg 60
acctgcaccg tctctggatt ctcactcagc aatgctagaa tgggtgtggg ctggatccgt 120
cagcccccag ggaaggccct ggagtggctc gcccacattt tttcgagcga cgaaaaatct 180
tttagggcat ctctgaagag caggctcacc atctccaagg acacctccaa aagccaggtg 240
gtccttacaa tgacc 255
<210> 977
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的VH2
<400> 977
Gln Val Thr Leu Arg Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Ala
20 25 30
Arg Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu
35 40 45
Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Phe Arg Ala Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val
65 70 75 80
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Ile Tyr Tyr
85 90 95
Cys Ala Arg Thr Ser Arg Ile Ser Pro Thr Gly Glu Ala Phe Asp Ile
100 105 110
Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser
115 120
<210> 978
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的VL2
<400> 978
Asp Ile Val Met Thr Gln Thr Pro Asp Phe Arg Ser Val Ala Pro Ala
1 5 10 15
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ile
20 25 30
Leu His Trp Tyr Gln Gln Lys Pro Asn Gln Ser Pro Val Leu Leu Ile
35 40 45
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Tyr Ser Leu Glu Ala
65 70 75 80
Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Arg Ser Leu Pro Gln
85 90 95
Thr Phe Gly Gln Gly Thr Lys Leu Glu Val Lys
100 105
<210> 979
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的H-FR1
<400> 979
Gln Val Thr Leu Arg Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Val Ser
20 25
<210> 980
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的H-FR2
<400> 980
Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala
1 5 10 15
His
<210> 981
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的H-FR3
<400> 981
Ser Phe Arg Ala Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr
1 5 10 15
Ser Lys Ser Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp
20 25 30
Thr Ala Ile Tyr Tyr Cys
35
<210> 982
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的H-FR4
<400> 982
Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser
1 5 10
<210> 983
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的L-FR1
<400> 983
Asp Ile Val Met Thr Gln Thr Pro Asp Phe Arg Ser Val Ala Pro Ala
1 5 10 15
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser
20 25
<210> 984
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的L-FR2
<400> 984
Leu His Trp Tyr Gln Gln Lys Pro Asn Gln Ser Pro Val Leu Leu Ile
1 5 10 15
Lys
<210> 985
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的L-FR3
<400> 985
Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Tyr Ser Leu Glu
20 25 30
Ala Glu Asp Ala
35
<210> 986
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-50A11的L-FR4
<400> 986
Phe Gly Gln Gly Thr Lys Leu Glu Val Lys
1 5 10
<210> 987
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的H-CDR1
<400> 987
Gly Phe Thr Phe Val Val Phe Pro
1 5
<210> 988
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的H-CDR2
<400> 988
Ile Ser Gly Ser Gly Gly Ser Thr
1 5
<210> 989
<211> 14
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的H-CDR3
<400> 989
Ala Ile Gly Gly Pro Leu Thr Ser His Asn Trp Phe Asp Pro
1 5 10
<210> 990
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的L-CDR1
<400> 990
Ser Gly Ser Ile Gly Ser Ser Tyr
1 5
<210> 991
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的L-CDR2
<400> 991
Glu Asp Ala
1
<210> 992
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的L-CDR3
<400> 992
Gln Ser Tyr Asp Gly Ser Asn His Phe Val
1 5 10
<210> 993
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的SCFV
<400> 993
caggtgcagc tggtagagtc ggggggaggc gtggtccagc ctggggggtc cctgaaactc 60
tcctgtgcag cctctggatt caccttcgtt gtctttccta tgcgctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
tcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa caccctgtat 240
ctgcaaatga acagt 255
<210> 994
<211> 121
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的VH2
<400> 994
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Val Phe
20 25 30
Pro Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ser Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Ile Gly Gly Pro Leu Thr Ser His Asn Trp Phe Asp Pro Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 995
<211> 111
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的VL2
<400> 995
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Gly Ser Ser
20 25 30
Tyr Ile Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
35 40 45
Met Tyr Glu Asp Ala Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
50 55 60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65 70 75 80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly
85 90 95
Ser Asn His Phe Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
100 105 110
<210> 996
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的H-FR1
<400> 996
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser
20 25
<210> 997
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的H-FR2
<400> 997
Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
1 5 10 15
Ala
<210> 998
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的H-FR3
<400> 998
Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 999
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的H-FR4
<400> 999
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 1000
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的L-FR1
<400> 1000
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
1 5 10 15
Thr Val Thr Ile Ser Cys Thr Arg Ser
20 25
<210> 1001
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的L-FR2
<400> 1001
Ile Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val Met
1 5 10 15
Tyr
<210> 1002
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的L-FR3
<400> 1002
Met Tyr Glu Asp Ala Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
20 25 30
Leu Lys Thr Glu
35
<210> 1003
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-54C01的L-FR4
<400> 1003
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
1 5 10
<210> 1004
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的H-CDR1
<400> 1004
Gly Phe Ser Leu Ser Asn Tyr Gly
1 5
<210> 1005
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的H-CDR2
<400> 1005
Ile Ser Ala Ser Ser Ser Tyr Lys
1 5
<210> 1006
<211> 15
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的H-CDR3
<400> 1006
Ala Arg Asp Arg Tyr Phe Tyr Gly Ser Gly Ser Tyr Pro Pro Ala
1 5 10 15
<210> 1007
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的L-CDR1
<400> 1007
Gln Ser Leu Leu Gln Thr Asn Gly Tyr Asn Tyr
1 5 10
<210> 1008
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的L-CDR2
<400> 1008
Leu Gly Ser
1
<210> 1009
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的L-CDR3
<400> 1009
Met His Ser Leu Gln Thr Pro Thr
1 5
<210> 1010
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的SCFV
<400> 1010
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cgtctggatt cagcctcagt aactatggca tgcactgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtatcatat attagtgcta gtagtagtta caagaagtac 180
gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240
ctgcaaatga acagt 255
<210> 1011
<211> 122
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的VH2
<400> 1011
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Asn Tyr
20 25 30
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Ser Ala Ser Ser Ser Tyr Lys Lys Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Arg Tyr Phe Tyr Gly Ser Gly Ser Tyr Pro Pro Ala Leu
100 105 110
Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 1012
<211> 111
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的VL2
<400> 1012
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Gln Thr
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Thr
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met His Ser
85 90 95
Leu Gln Thr Pro Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1013
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的H-FR1
<400> 1013
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser
20 25
<210> 1014
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的H-FR2
<400> 1014
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
1 5 10 15
Tyr
<210> 1015
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的H-FR3
<400> 1015
Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
1 5 10 15
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 1016
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的H-FR4
<400> 1016
Leu Gly Arg Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 1017
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的L-FR1
<400> 1017
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser
20 25
<210> 1018
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的L-FR2
<400> 1018
Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Thr Pro Gln Leu Leu Ile
1 5 10 15
Tyr
<210> 1019
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的L-FR3
<400> 1019
Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 1020
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59A11的L-FR4
<400> 1020
Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 1021
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的H-CDR1
<400> 1021
Gly Phe Asn Phe Gly Asp Tyr Ala
1 5
<210> 1022
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的H-CDR2
<400> 1022
Thr Ser Ser Lys His Tyr Gly Gly Thr Ile
1 5 10
<210> 1023
<211> 14
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的H-CDR3
<400> 1023
Ala Lys Gly Lys Trp Leu Arg Phe Asp Ser Pro Phe Asp Ser
1 5 10
<210> 1024
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的L-CDR1
<400> 1024
Gln Ser Leu Leu His Asn Asn Gly Asn Lys Phe
1 5 10
<210> 1025
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的L-CDR2
<400> 1025
Leu Gly Ser
1
<210> 1026
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的L-CDR3
<400> 1026
Met Gln Ala Leu Arg Thr Pro Trp Thr
1 5
<210> 1027
<211> 255
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的SCFV
<400> 1027
caggtgcagc tggtgcagtc tgggggaggc ttggtaaagc cagggcggtc ccagagactc 60
tcctgtacag gttctggatt caactttggt gattatgcca tcagttggat ccgccaggct 120
ccagggaagg ggctggagtg ggtcggcttc actagcagca aacattatgg tgggacaata 180
gactacgccg cgtctgtgaa aggcagattc atcatctcaa gagatgattc gaaaagcacc 240
gcctatctgc aaatg 255
<210> 1028
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的VH2
<400> 1028
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
1 5 10 15
Ser Gln Arg Leu Ser Cys Thr Gly Ser Gly Phe Asn Phe Gly Asp Tyr
20 25 30
Ala Ile Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Gly Phe Thr Ser Ser Lys His Tyr Gly Gly Thr Ile Asp Tyr Ala Ala
50 55 60
Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asp Ser Lys Ser Thr
65 70 75 80
Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95
Tyr Cys Ala Lys Gly Lys Trp Leu Arg Phe Asp Ser Pro Phe Asp Ser
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 1029
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的VL2
<400> 1029
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Asn
20 25 30
Asn Gly Asn Lys Phe Phe Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Arg Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 1030
<211> 25
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的H-FR1
<400> 1030
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
1 5 10 15
Ser Gln Arg Leu Ser Cys Thr Gly Ser
20 25
<210> 1031
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的H-FR2
<400> 1031
Ile Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
1 5 10 15
Phe
<210> 1032
<211> 38
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的H-FR3
<400> 1032
Asp Tyr Ala Ala Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asp
1 5 10 15
Ser Lys Ser Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
20 25 30
Thr Ala Val Tyr Tyr Cys
35
<210> 1033
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的H-FR4
<400> 1033
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
1 5 10
<210> 1034
<211> 26
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的L-FR1
<400> 1034
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser
20 25
<210> 1035
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的L-FR2
<400> 1035
Phe Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
1 5 10 15
Tyr
<210> 1036
<211> 36
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的L-FR3
<400> 1036
Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser
1 5 10 15
Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Lys Ile Ser Arg Val Glu
20 25 30
Ala Glu Asp Val
35
<210> 1037
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56-59E12的L-FR4
<400> 1037
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
1 5 10
<210> 1038
<211> 310
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白的氨基酸序列
<400> 1038
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Thr Pro Phe Pro Gln Thr Ser Lys Lys Ile Gly Asp Asp Ala Thr Leu
20 25 30
Ser Cys Asn Arg Asn Asn Thr Asn Asp Tyr Val Val Met Ser Ala Trp
35 40 45
Tyr Lys Glu Pro Asn Ser Ile Ile Leu Leu Ala Ala Lys Ser Asp Val
50 55 60
Leu Tyr Phe Asp Asn Tyr Thr Lys Asp Lys Ile Ser Tyr Asp Ser Pro
65 70 75 80
Tyr Asp Asp Leu Val Thr Thr Ile Thr Ile Lys Ser Leu Thr Ala Arg
85 90 95
Asp Ala Gly Thr Tyr Val Cys Ala Phe Phe Met Thr Ser Pro Thr Asn
100 105 110
Asp Thr Asp Lys Val Asp Tyr Glu Glu Tyr Ser Thr Glu Leu Ile Val
115 120 125
Asn Thr Asp Ser Glu Ser Thr Ile Asp Ile Ile Leu Ser Gly Ser Thr
130 135 140
His Ser Pro Glu Thr Ser Ser Glu Lys Pro Glu Asp Ile Asp Asn Phe
145 150 155 160
Asn Cys Ser Ser Val Phe Glu Ile Ala Thr Pro Glu Pro Ile Thr Asp
165 170 175
Asn Val Glu Asp His Thr Asp Thr Val Thr Tyr Thr Ser Asp Ser Ile
180 185 190
Asn Thr Val Ser Ala Ser Ser Gly Glu Ser Thr Thr Asp Glu Thr Pro
195 200 205
Glu Pro Ile Thr Asp Lys Glu Glu Asp His Thr Val Thr Asp Thr Val
210 215 220
Ser Tyr Thr Thr Val Ser Thr Ser Ser Gly Ile Val Thr Thr Lys Ser
225 230 235 240
Thr Thr Asp Asp Ala Tyr Asn Asp Asn Asp Thr Val Pro Ser Thr Thr
245 250 255
Val Gly Ser Ser Thr Thr Ser Ile Ser Asn Tyr Lys Thr Lys Asp Phe
260 265 270
Val Glu Ile Phe Gly Ile Thr Ala Leu Ile Ile Leu Ser Ala Val Ala
275 280 285
Ile Phe Cys Ile Thr Tyr Tyr Ile Cys Asn Lys Arg Ser Arg Lys Tyr
290 295 300
Lys Thr Glu Asn Lys Pro
305 310
<210> 1039
<211> 930
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白的核苷酸序列
<400> 1039
atgacacgat taccaatact tttgttacta atatcattag tatacgctac accttttcct 60
cagacatcta aaaaaatagg tgatgatgca actctatcat gtaatcgaaa taatacaaat 120
gactacgttg ttatgagtgc ttggtataag gagcccaatt ccattattct tttagctgct 180
aaaagcgacg tcttgtattt tgataattat accaaggata aaatatctta cgactctcca 240
tacgatgatc tagttacaac tatcacaatt aaatcattga ctgctagaga tgccggtact 300
tatgtatgtg cattctttat gacatcacct acaaatgaca ctgataaagt agattatgaa 360
gaatactcca cagagttgat tgtaaataca gatagtgaat cgactataga cataatacta 420
tctggatcta cacattcacc agaaactagt tctgagaaac cagaggatat agataatttt 480
aattgctcgt cggtattcga aatcgcgact ccggaaccaa ttactgataa tgtagaagat 540
catacagaca ccgtcacata cactagtgat agcattaata cagtaagtgc atcatctgga 600
gaatccacaa cagacgagac tccggaacca attactgata aagaagaaga tcatacagtc 660
acagacactg tctcatacac tacagtaagt acatcatctg gaattgtcac tactaaatca 720
accaccgatg atacgtacaa tgataatgat acagtaccac caactactgt aggcagtagt 780
acaacctcta ttagcaatta taaaaccaag gactttgtag aaatatttgg tattaccgca 840
ttaattatat tgtcggccgt ggcaatattc tgtattacgt attatatatg taataaacgt 900
tcacgtaaat acaaaacaga gaacaagccg 930
<210> 1040
<211> 270
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56 蛋白片段(BN-A56-S)的氨基酸序列
<400> 1040
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Thr Pro Phe Pro Gln Thr Ser Lys Lys Ile Gly Asp Asp Ala Thr Leu
20 25 30
Ser Cys Asn Arg Asn Asn Thr Asn Asp Tyr Val Val Met Ser Ala Trp
35 40 45
Tyr Lys Glu Pro Asn Ser Ile Ile Leu Leu Ala Ala Lys Ser Asp Val
50 55 60
Leu Tyr Phe Asp Asn Tyr Thr Lys Asp Lys Ile Ser Tyr Asp Ser Pro
65 70 75 80
Tyr Asp Asp Leu Val Thr Thr Ile Thr Ile Lys Ser Leu Thr Ala Arg
85 90 95
Asp Ala Gly Thr Tyr Val Cys Ala Phe Phe Met Thr Ser Pro Thr Asn
100 105 110
Asp Thr Asp Lys Val Asp Tyr Glu Glu Tyr Ser Thr Glu Leu Ile Val
115 120 125
Asn Thr Asp Ser Glu Ser Thr Ile Asp Ile Ile Leu Ser Gly Ser Thr
130 135 140
His Ser Pro Glu Thr Ser Ser Glu Lys Pro Glu Asp Ile Asp Asn Phe
145 150 155 160
Asn Cys Ser Ser Val Phe Glu Ile Ala Thr Pro Glu Pro Ile Thr Asp
165 170 175
Asn Val Glu Asp His Thr Asp Thr Val Thr Tyr Thr Ser Asp Ser Ile
180 185 190
Asn Thr Val Ser Ala Ser Ser Gly Glu Ser Thr Thr Asp Glu Thr Pro
195 200 205
Glu Pro Ile Thr Asp Lys Glu Glu Asp His Thr Val Thr Asp Thr Val
210 215 220
Ser Tyr Thr Thr Val Ser Thr Ser Ser Gly Ile Val Thr Thr Lys Ser
225 230 235 240
Thr Thr Asp Asp Ala Tyr Asn Asp Asn Asp Thr Val Pro Ser Thr Thr
245 250 255
Val Gly Ser Ser Thr Thr Ser Ile Ser Asn Tyr Lys Thr Lys
260 265 270
<210> 1041
<211> 810
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56 蛋白片段(BN-A56-S)的核苷酸序列
<400> 1041
atgacacgat taccaatact tttgttacta atatcattag tatacgctac accttttcct 60
cagacatcta aaaaaatagg tgatgatgca actctatcat gtaatcgaaa taatacaaat 120
gactacgttg ttatgagtgc ttggtataag gagcccaatt ccattattct tttagctgct 180
aaaagcgacg tcttgtattt tgataattat accaaggata aaatatctta cgactctcca 240
tacgatgatc tagttacaac tatcacaatt aaatcattga ctgctagaga tgccggtact 300
tatgtatgtg cattctttat gacatcacct acaaatgaca ctgataaagt agattatgaa 360
gaatactcca cagagttgat tgtaaataca gatagtgaat cgactataga cataatacta 420
tctggatcta cacattcacc agaaactagt tctgagaaac cagaggatat agataatttt 480
aattgctcgt cggtattcga aatcgcgact ccggaaccaa ttactgataa tgtagaagat 540
catacagaca ccgtcacata cactagtgat agcattaata cagtaagtgc atcatctgga 600
gaatccacaa cagacgagac tccggaacca attactgata aagaagaaga tcatacagtc 660
acagacactg tctcatacac tacagtaagt acatcatctg gaattgtcac tactaaatca 720
accaccgatg atacgtacaa tgataatgat acagtaccac caactactgt aggcagtagt 780
acaacctcta ttagcaatta taaaaccaag 810
<210> 1042
<211> 300
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56 片段(BN-A56-17)的氨基酸序列
<400> 1042
Thr Pro Phe Pro Gln Thr Ser Lys Lys Ile Gly Asp Asp Ala Thr Leu
1 5 10 15
Ser Cys Asn Arg Asn Asn Thr Asn Asp Tyr Val Val Met Ser Ala Trp
20 25 30
Tyr Lys Glu Pro Asn Ser Ile Ile Leu Leu Ala Ala Lys Ser Asp Val
35 40 45
Leu Tyr Phe Asp Asn Tyr Thr Lys Asp Lys Ile Ser Tyr Asp Ser Pro
50 55 60
Tyr Asp Asp Leu Val Thr Thr Ile Thr Ile Lys Ser Leu Thr Ala Arg
65 70 75 80
Asp Ala Gly Thr Tyr Val Cys Ala Phe Phe Met Thr Ser Pro Thr Asn
85 90 95
Asp Thr Asp Lys Val Asp Tyr Glu Glu Gly Gly Gly Gly Gly Gly Tyr
100 105 110
Ser Thr Glu Leu Ile Val Asn Thr Asp Ser Glu Ser Thr Ile Asp Ile
115 120 125
Ile Leu Ser Gly Ser Thr His Ser Pro Glu Thr Ser Ser Glu Lys Pro
130 135 140
Glu Asp Ile Asp Asn Phe Asn Cys Ser Ser Val Phe Glu Ile Ala Thr
145 150 155 160
Pro Glu Pro Ile Thr Asp Asn Val Glu Asp His Thr Asp Thr Val Thr
165 170 175
Tyr Thr Ser Asp Ser Ile Asn Thr Val Ser Ala Ser Ser Gly Glu Ser
180 185 190
Thr Thr Asp Glu Thr Pro Glu Pro Ile Thr Asp Lys Glu Glu Asp His
195 200 205
Thr Val Thr Asp Thr Val Ser Tyr Thr Thr Val Ser Thr Ser Ser Gly
210 215 220
Ile Val Thr Thr Lys Ser Thr Thr Asp Asp Ala Tyr Asn Asp Asn Asp
225 230 235 240
Thr Val Pro Ser Thr Thr Val Gly Ser Ser Thr Thr Ser Ile Ser Asn
245 250 255
Tyr Lys Thr Lys Asp Phe Val Glu Ile Phe Gly Ile Thr Ala Leu Ile
260 265 270
Ile Leu Ser Ala Val Ala Ile Phe Cys Ile Thr Tyr Tyr Ile Cys Asn
275 280 285
Lys Arg Ser Arg Lys Tyr Lys Thr Glu Asn Lys Pro
290 295 300
<210> 1043
<211> 900
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56片段 (BN-A56-17)的核苷酸序列
<400> 1043
acaccttttc ctcagacatc taaaaaaata ggtgatgatg caactctatc atgtaatcga 60
aataatacaa atgactacgt tgttatgagt gcttggtata aggagcccaa ttccattatt 120
cttttagctg ctaaaagcga cgtcttgtat tttgataatt ataccaagga taaaatatct 180
tacgactctc catacgatga tctagttaca actatcacaa ttaaatcatt gactgctaga 240
gatgccggta cttatgtatg tgcattcttt atgacatcac ctacaaatga cactgataaa 300
gtagattatg aagaaggcgg cggcggcggc ggctactcca cagagttgat tgtaaataca 360
gatagtgaat cgactataga cataatacta tctggatcta cacattcacc agaaactagt 420
tctgagaaac cagaggatat agataatttt aattgctcgt cggtattcga aatcgcgact 480
ccggaaccaa ttactgataa tgtagaagat catacagaca ccgtcacata cactagtgat 540
agcattaata cagtaagtgc atcatctgga gaatccacaa cagacgagac tccggaacca 600
attactgata aagaagaaga tcatacagtc acagacactg tctcatacac tacagtaagt 660
acatcatctg gaattgtcac tactaaatca accaccgatg atacgtacaa tgataatgat 720
acagtaccac caactactgt aggcagtagt acaacctcta ttagcaatta taaaaccaag 780
gactttgtag aaatatttgg tattaccgca ttaattatat tgtcggccgt ggcaatattc 840
tgtattacgt attatatatg taataaacgt tcacgtaaat acaaaacaga gaacaagccg 900
900
<210> 1044
<211> 267
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56 蛋白片段(BN-A56-170)的氨基酸序列
<400> 1044
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Thr Pro Phe Pro Gln Thr Ser Lys Lys Ile Gly Asp Asp Ala Thr Leu
20 25 30
Ser Cys Asn Arg Asn Asn Thr Asn Asp Tyr Val Val Met Ser Ala Trp
35 40 45
Tyr Lys Glu Pro Asn Ser Ile Ile Leu Leu Ala Ala Lys Ser Asp Val
50 55 60
Leu Tyr Phe Asp Asn Tyr Thr Lys Asp Lys Ile Ser Tyr Asp Ser Pro
65 70 75 80
Tyr Asp Asp Leu Val Thr Thr Ile Thr Ile Lys Ser Leu Thr Ala Arg
85 90 95
Asp Ala Gly Thr Tyr Val Cys Ala Phe Phe Met Thr Ser Pro Thr Asn
100 105 110
Asp Thr Asp Lys Val Asp Tyr Glu Glu Gly Gly Gly Gly Gly Gly Pro
115 120 125
Glu Pro Ile Thr Asp Asn Val Glu Asp His Thr Asp Thr Val Thr Tyr
130 135 140
Thr Ser Asp Ser Ile Asn Thr Val Ser Ala Ser Ser Gly Glu Ser Thr
145 150 155 160
Thr Asp Glu Thr Pro Glu Pro Ile Thr Asp Lys Glu Glu Asp His Thr
165 170 175
Val Thr Asp Thr Val Ser Tyr Thr Thr Val Ser Thr Ser Ser Gly Ile
180 185 190
Val Thr Thr Lys Ser Thr Thr Asp Asp Ala Tyr Asn Asp Asn Asp Thr
195 200 205
Val Pro Ser Thr Thr Val Gly Ser Ser Thr Thr Ser Ile Ser Asn Tyr
210 215 220
Lys Thr Lys Asp Phe Val Glu Ile Phe Gly Ile Thr Ala Leu Ile Ile
225 230 235 240
Leu Ser Ala Val Ala Ile Phe Cys Ile Thr Tyr Tyr Ile Cys Asn Lys
245 250 255
Arg Ser Arg Lys Tyr Lys Thr Glu Asn Lys Pro
260 265
<210> 1045
<211> 801
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (BN-A56-170) 的核苷酸序列
<400> 1045
atgacacgat taccaatact tttgttacta atatcattag tatacgctac accttttcct 60
cagacatcta aaaaaatagg tgatgatgca actctatcat gtaatcgaaa taatacaaat 120
gactacgttg ttatgagtgc ttggtataag gagcccaatt ccattattct tttagctgct 180
aaaagcgacg tcttgtattt tgataattat accaaggata aaatatctta cgactctcca 240
tacgatgatc tagttacaac tatcacaatt aaatcattga ctgctagaga tgccggtact 300
tatgtatgtg cattctttat gacatcacct acaaatgaca ctgataaagt agattatgaa 360
gaaggcggcg gcggcggcgg cccggaacca attactgata atgtagaaga tcatacagac 420
accgtcacat acactagtga tagcattaat acagtaagtg catcatctgg agaatccaca 480
acagacgaga ctccggaacc aattactgat aaagaagaag atcatacagt cacagacact 540
gtctcataca ctacagtaag tacatcatct ggaattgtca ctactaaatc aaccaccgat 600
gatacgtaca atgataatga tacagtacca ccaactactg taggcagtag tacaacctct 660
attagcaatt ataaaaccaa ggactttgta gaaatatttg gtattaccgc attaattata 720
ttgtcggccg tggcaatatt ctgtattacg tattatatat gtaataaacg ttcacgtaaa 780
tacaaaacag agaacaagcc g 801
<210> 1046
<211> 197
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (BN-A56-240) 的氨基酸序列
<400> 1046
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Thr Pro Phe Pro Gln Thr Ser Lys Lys Ile Gly Asp Asp Ala Thr Leu
20 25 30
Ser Cys Asn Arg Asn Asn Thr Asn Asp Tyr Val Val Met Ser Ala Trp
35 40 45
Tyr Lys Glu Pro Asn Ser Ile Ile Leu Leu Ala Ala Lys Ser Asp Val
50 55 60
Leu Tyr Phe Asp Asn Tyr Thr Lys Asp Lys Ile Ser Tyr Asp Ser Pro
65 70 75 80
Tyr Asp Asp Leu Val Thr Thr Ile Thr Ile Lys Ser Leu Thr Ala Arg
85 90 95
Asp Ala Gly Thr Tyr Val Cys Ala Phe Phe Met Thr Ser Pro Thr Asn
100 105 110
Asp Thr Asp Lys Val Asp Tyr Glu Glu Gly Gly Gly Gly Gly Gly Thr
115 120 125
Thr Asp Asp Ala Tyr Asn Asp Asn Asp Thr Val Pro Ser Thr Thr Val
130 135 140
Gly Ser Ser Thr Thr Ser Ile Ser Asn Tyr Lys Thr Lys Asp Phe Val
145 150 155 160
Glu Ile Phe Gly Ile Thr Ala Leu Ile Ile Leu Ser Ala Val Ala Ile
165 170 175
Phe Cys Ile Thr Tyr Tyr Ile Cys Asn Lys Arg Ser Arg Lys Tyr Lys
180 185 190
Thr Glu Asn Lys Pro
195
<210> 1047
<211> 591
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (BN-A56-240) 的核苷酸序列
<400> 1047
atgacacgat taccaatact tttgttacta atatcattag tatacgctac accttttcct 60
cagacatcta aaaaaatagg tgatgatgca actctatcat gtaatcgaaa taatacaaat 120
gactacgttg ttatgagtgc ttggtataag gagcccaatt ccattattct tttagctgct 180
aaaagcgacg tcttgtattt tgataattat accaaggata aaatatctta cgactctcca 240
tacgatgatc tagttacaac tatcacaatt aaatcattga ctgctagaga tgccggtact 300
tatgtatgtg cattctttat gacatcacct acaaatgaca ctgataaagt agattatgaa 360
gaaggcggcg gcggcggcgg caccaccgat gatacgtaca atgataatga tacagtacca 420
ccaactactg taggcagtag tacaacctct attagcaatt ataaaaccaa ggactttgta 480
gaaatatttg gtattaccgc attaattata ttgtcggccg tggcaatatt ctgtattacg 540
tattatatat gtaataaacg ttcacgtaaa tacaaaacag agaacaagcc g 591
<210> 1048
<211> 167
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (BN-A56-276) 的氨基酸序列
<400> 1048
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Thr Pro Phe Pro Gln Thr Ser Lys Lys Ile Gly Asp Asp Ala Thr Leu
20 25 30
Ser Cys Asn Arg Asn Asn Thr Asn Asp Tyr Val Val Met Ser Ala Trp
35 40 45
Tyr Lys Glu Pro Asn Ser Ile Ile Leu Leu Ala Ala Lys Ser Asp Val
50 55 60
Leu Tyr Phe Asp Asn Tyr Thr Lys Asp Lys Ile Ser Tyr Asp Ser Pro
65 70 75 80
Tyr Asp Asp Leu Val Thr Thr Ile Thr Ile Lys Ser Leu Thr Ala Arg
85 90 95
Asp Ala Gly Thr Tyr Val Cys Ala Phe Phe Met Thr Ser Pro Thr Asn
100 105 110
Asp Thr Asp Lys Val Asp Tyr Glu Glu Gly Gly Gly Gly Gly Gly Asp
115 120 125
Phe Val Glu Ile Phe Gly Ile Thr Ala Leu Ile Ile Leu Ser Ala Val
130 135 140
Ala Ile Phe Cys Ile Thr Tyr Tyr Ile Cys Asn Lys Arg Ser Arg Lys
145 150 155 160
Tyr Lys Thr Glu Asn Lys Pro
165
<210> 1049
<211> 501
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (BN-A56-276) 的核苷酸序列
<400> 1049
atgacacgat taccaatact tttgttacta atatcattag tatacgctac accttttcct 60
cagacatcta aaaaaatagg tgatgatgca actctatcat gtaatcgaaa taatacaaat 120
gactacgttg ttatgagtgc ttggtataag gagcccaatt ccattattct tttagctgct 180
aaaagcgacg tcttgtattt tgataattat accaaggata aaatatctta cgactctcca 240
tacgatgatc tagttacaac tatcacaatt aaatcattga ctgctagaga tgccggtact 300
tatgtatgtg cattctttat gacatcacct acaaatgaca ctgataaagt agattatgaa 360
gaaggcggcg gcggcggcgg cgactttgta gaaatatttg gtattaccgc attaattata 420
ttgtcggccg tggcaatatt ctgtattacg tattatatat gtaataaacg ttcacgtaaa 480
tacaaaacag agaacaagcc g 501
<210> 1050
<211> 205
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-121) 的氨基酸序列
<400> 1050
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Tyr Ser Thr Glu Leu Ile Val Asn Thr Asp Ser Glu Ser Thr Ile Asp
20 25 30
Ile Ile Leu Ser Gly Ser Thr His Ser Pro Glu Thr Ser Ser Glu Lys
35 40 45
Pro Glu Asp Ile Asp Asn Phe Asn Cys Ser Ser Val Phe Glu Ile Ala
50 55 60
Thr Pro Glu Pro Ile Thr Asp Asn Val Glu Asp His Thr Asp Thr Val
65 70 75 80
Thr Tyr Thr Ser Asp Ser Ile Asn Thr Val Ser Ala Ser Ser Gly Glu
85 90 95
Ser Thr Thr Asp Glu Thr Pro Glu Pro Ile Thr Asp Lys Glu Glu Asp
100 105 110
His Thr Val Thr Asp Thr Val Ser Tyr Thr Thr Val Ser Thr Ser Ser
115 120 125
Gly Ile Val Thr Thr Lys Ser Thr Thr Asp Asp Ala Tyr Asn Asp Asn
130 135 140
Asp Thr Val Pro Ser Thr Thr Val Gly Ser Ser Thr Thr Ser Ile Ser
145 150 155 160
Asn Tyr Lys Thr Lys Asp Phe Val Glu Ile Phe Gly Ile Thr Ala Leu
165 170 175
Ile Ile Leu Ser Ala Val Ala Ile Phe Cys Ile Thr Tyr Tyr Ile Cys
180 185 190
Asn Lys Arg Ser Arg Lys Tyr Lys Thr Glu Asn Lys Pro
195 200 205
<210> 1051
<211> 615
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-121) 的核苷酸序列
<400> 1051
atgacacgat taccaatact tttgttacta atatcattag tatacgctta ctccacagag 60
ttgattgtaa atacagatag tgaatcgact atagacataa tactatctgg atctacacat 120
tcaccagaaa ctagttctga gaaaccagag gatatagata attttaattg ctcgtcggta 180
ttcgaaatcg cgactccgga accaattact gataatgtag aagatcatac agacaccgtc 240
acatacacta gtgatagcat taatacagta agtgcatcat ctggagaatc cacaacagac 300
gagactccgg aaccaattac tgataaagaa gaagatcata cagtcacaga cactgtctca 360
tacactacag taagtacatc atctggaatt gtcactacta aatcaaccac cgatgatacg 420
tacaatgata atgatacagt accaccaact actgtaggca gtagtacaac ctctattagc 480
aattataaaa ccaaggactt tgtagaaata tttggtatta ccgcattaat tatattgtcg 540
gccgtggcaa tattctgtat tacgtattat atatgtaata aacgttcacg taaatacaaa 600
acagagaaca agccg 615
<210> 1052
<211> 189
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-17) 的氨基酸序列
<400> 1052
Tyr Ser Thr Glu Leu Ile Val Asn Thr Asp Ser Glu Ser Thr Ile Asp
1 5 10 15
Ile Ile Leu Ser Gly Ser Thr His Ser Pro Glu Thr Ser Ser Glu Lys
20 25 30
Pro Glu Asp Ile Asp Asn Phe Asn Cys Ser Ser Val Phe Glu Ile Ala
35 40 45
Thr Pro Glu Pro Ile Thr Asp Asn Val Glu Asp His Thr Asp Thr Val
50 55 60
Thr Tyr Thr Ser Asp Ser Ile Asn Thr Val Ser Ala Ser Ser Gly Glu
65 70 75 80
Ser Thr Thr Asp Glu Thr Pro Glu Pro Ile Thr Asp Lys Glu Glu Asp
85 90 95
His Thr Val Thr Asp Thr Val Ser Tyr Thr Thr Val Ser Thr Ser Ser
100 105 110
Gly Ile Val Thr Thr Lys Ser Thr Thr Asp Asp Ala Tyr Asn Asp Asn
115 120 125
Asp Thr Val Pro Ser Thr Thr Val Gly Ser Ser Thr Thr Ser Ile Ser
130 135 140
Asn Tyr Lys Thr Lys Asp Phe Val Glu Ile Phe Gly Ile Thr Ala Leu
145 150 155 160
Ile Ile Leu Ser Ala Val Ala Ile Phe Cys Ile Thr Tyr Tyr Ile Cys
165 170 175
Asn Lys Arg Ser Arg Lys Tyr Lys Thr Glu Asn Lys Pro
180 185
<210> 1053
<211> 567
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-17) 的核苷酸序列
<400> 1053
tactccacag agttgattgt aaatacagat agtgaatcga ctatagacat aatactatct 60
ggatctacac attcaccaga aactagttct gagaaaccag aggatataga taattttaat 120
tgctcgtcgg tattcgaaat cgcgactccg gaaccaatta ctgataatgt agaagatcat 180
acagacaccg tcacatacac tagtgatagc attaatacag taagtgcatc atctggagaa 240
tccacaacag acgagactcc ggaaccaatt actgataaag aagaagatca tacagtcaca 300
gacactgtct catacactac agtaagtaca tcatctggaa ttgtcactac taaatcaacc 360
accgatgata cgtacaatga taatgataca gtaccaccaa ctactgtagg cagtagtaca 420
acctctatta gcaattataa aaccaaggac tttgtagaaa tatttggtat taccgcatta 480
attatattgt cggccgtggc aatattctgt attacgtatt atatatgtaa taaacgttca 540
cgtaaataca aaacagagaa caagccg 567
<210> 1054
<211> 165
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-121S) 的氨基酸序列
<400> 1054
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Tyr Ser Thr Glu Leu Ile Val Asn Thr Asp Ser Glu Ser Thr Ile Asp
20 25 30
Ile Ile Leu Ser Gly Ser Thr His Ser Pro Glu Thr Ser Ser Glu Lys
35 40 45
Pro Glu Asp Ile Asp Asn Phe Asn Cys Ser Ser Val Phe Glu Ile Ala
50 55 60
Thr Pro Glu Pro Ile Thr Asp Asn Val Glu Asp His Thr Asp Thr Val
65 70 75 80
Thr Tyr Thr Ser Asp Ser Ile Asn Thr Val Ser Ala Ser Ser Gly Glu
85 90 95
Ser Thr Thr Asp Glu Thr Pro Glu Pro Ile Thr Asp Lys Glu Glu Asp
100 105 110
His Thr Val Thr Asp Thr Val Ser Tyr Thr Thr Val Ser Thr Ser Ser
115 120 125
Gly Ile Val Thr Thr Lys Ser Thr Thr Asp Asp Ala Tyr Asn Asp Asn
130 135 140
Asp Thr Val Pro Ser Thr Thr Val Gly Ser Ser Thr Thr Ser Ile Ser
145 150 155 160
Asn Tyr Lys Thr Lys
165
<210> 1055
<211> 495
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-121S) 的核苷酸序列
<400> 1055
atgacacgat taccaatact tttgttacta atatcattag tatacgctta ctccacagag 60
ttgattgtaa atacagatag tgaatcgact atagacataa tactatctgg atctacacat 120
tcaccagaaa ctagttctga gaaaccagag gatatagata attttaattg ctcgtcggta 180
ttcgaaatcg cgactccgga accaattact gataatgtag aagatcatac agacaccgtc 240
acatacacta gtgatagcat taatacagta agtgcatcat ctggagaatc cacaacagac 300
gagactccgg aaccaattac tgataaagaa gaagatcata cagtcacaga cactgtctca 360
tacactacag taagtacatc atctggaatt gtcactacta aatcaaccac cgatgatacg 420
tacaatgata atgatacagt accaccaact actgtaggca gtagtacaac ctctattagc 480
aattataaaa ccaag 495
<210> 1056
<211> 156
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-170) 的氨基酸序列
<400> 1056
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Pro Glu Pro Ile Thr Asp Asn Val Glu Asp His Thr Asp Thr Val Thr
20 25 30
Tyr Thr Ser Asp Ser Ile Asn Thr Val Ser Ala Ser Ser Gly Glu Ser
35 40 45
Thr Thr Asp Glu Thr Pro Glu Pro Ile Thr Asp Lys Glu Glu Asp His
50 55 60
Thr Val Thr Asp Thr Val Ser Tyr Thr Thr Val Ser Thr Ser Ser Gly
65 70 75 80
Ile Val Thr Thr Lys Ser Thr Thr Asp Asp Ala Tyr Asn Asp Asn Asp
85 90 95
Thr Val Pro Ser Thr Thr Val Gly Ser Ser Thr Thr Ser Ile Ser Asn
100 105 110
Tyr Lys Thr Lys Asp Phe Val Glu Ile Phe Gly Ile Thr Ala Leu Ile
115 120 125
Ile Leu Ser Ala Val Ala Ile Phe Cys Ile Thr Tyr Tyr Ile Cys Asn
130 135 140
Lys Arg Ser Arg Lys Tyr Lys Thr Glu Asn Lys Pro
145 150 155
<210> 1057
<211> 468
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-170) 的核苷酸序列
<400> 1057
atgacacgat taccaatact tttgttacta atatcattag tatacgctcc ggaaccaatt 60
actgataatg tagaagatca tacagacacc gtcacataca ctagtgatag cattaataca 120
gtaagtgcat catctggaga atccacaaca gacgagactc cggaaccaat tactgataaa 180
gaagaagatc atacagtcac agacactgtc tcatacacta cagtaagtac atcatctgga 240
attgtcacta ctaaatcaac caccgatgat acgtacaatg ataatgatac agtaccacca 300
actactgtag gcagtagtac aacctctatt agcaattata aaaccaagga ctttgtagaa 360
atatttggta ttaccgcatt aattatattg tcggccgtgg caatattctg tattacgtat 420
tatatatgta ataaacgttc acgtaaatac aaaacagaga acaagccg 468
<210> 1058
<211> 86
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-240) 的氨基酸序列
<400> 1058
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Thr Thr Asp Asp Ala Tyr Asn Asp Asn Asp Thr Val Pro Ser Thr Thr
20 25 30
Val Gly Ser Ser Thr Thr Ser Ile Ser Asn Tyr Lys Thr Lys Asp Phe
35 40 45
Val Glu Ile Phe Gly Ile Thr Ala Leu Ile Ile Leu Ser Ala Val Ala
50 55 60
Ile Phe Cys Ile Thr Tyr Tyr Ile Cys Asn Lys Arg Ser Arg Lys Tyr
65 70 75 80
Lys Thr Glu Asn Lys Pro
85
<210> 1059
<211> 258
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-240) 的核苷酸序列
<400> 1059
atgacacgat taccaatact tttgttacta atatcattag tatacgctac caccgatgat 60
acgtacaatg ataatgatac agtaccacca actactgtag gcagtagtac aacctctatt 120
agcaattata aaaccaagga ctttgtagaa atatttggta ttaccgcatt aattatattg 180
tcggccgtgg caatattctg tattacgtat tatatatgta ataaacgttc acgtaaatac 240
aaaacagaga acaagccg 258
<210> 1060
<211> 56
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-276) 的氨基酸序列
<400> 1060
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Asp Phe Val Glu Ile Phe Gly Ile Thr Ala Leu Ile Ile Leu Ser Ala
20 25 30
Val Ala Ile Phe Cys Ile Thr Tyr Tyr Ile Cys Asn Lys Arg Ser Arg
35 40 45
Lys Tyr Lys Thr Glu Asn Lys Pro
50 55
<210> 1061
<211> 168
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (A56-276) 的核苷酸序列
<400> 1061
atgacacgat taccaatact tttgttacta atatcattag tatacgctga ctttgtagaa 60
atatttggta ttaccgcatt aattatattg tcggccgtgg caatattctg tattacgtat 120
tatatatgta ataaacgttc acgtaaatac aaaacagaga acaagccg 168
<210> 1062
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> VH-CDR1 (LakePharma 变体3)
<400> 1062
Gly Tyr Ser Phe Thr Gly Tyr Thr
1 5
<210> 1063
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> LakePharma 变体4的H-CDR1
<400> 1063
Gly Tyr Ser Phe Thr Gly Tyr Thr
1 5
<210> 1064
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> LakePharma 变体3的H-CDR2
<400> 1064
Ile Asn Pro Tyr Asn Gly Gly Thr
1 5
<210> 1065
<211> 14
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> LakePharma 变体 3,4的H-CDR3
<400> 1065
Ala Arg Ser His Tyr Arg Tyr Asp Tyr Trp Tyr Phe Asp Val
1 5 10
<210> 1066
<211> 11
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> LakePharma 变体 3,4的L-CDR1
<400> 1066
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr
1 5 10
<210> 1067
<211> 3
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> LakePharma 变体 3,4的L-CDR2
<400> 1067
Lys Val Ser
1
<210> 1068
<211> 10
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> LakePharma 变体 3,4的L-CDR3
<400> 1068
Ser Gln Ser Thr His Val Pro Pro Phe Thr
1 5 10
<210> 1069
<211> 445
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> LakePharma变体 3,4 的VH
<400> 1069
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Met Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile
35 40 45
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser His Tyr Arg Tyr Asp Tyr Trp Tyr Phe Asp Val Trp Gly
100 105 110
Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser
115 120 125
Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val
130 135 140
Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val
145 150 155 160
Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
165 170 175
Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro
180 185 190
Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro
195 200 205
Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly
210 215 220
Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile
225 230 235 240
Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys
245 250 255
Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln
260 265 270
Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln
275 280 285
Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu
290 295 300
Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg
305 310 315 320
Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
325 330 335
Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro
340 345 350
Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr
355 360 365
Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln
370 375 380
Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly
385 390 395 400
Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu
405 410 415
Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn
420 425 430
His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys
435 440 445
<210> 1070
<211> 445
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> LakePharma变体 4的VH
<400> 1070
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Met Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile
35 40 45
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Ser His Tyr Arg Tyr Asp Tyr Trp Tyr Phe Asp Val Trp Gly
100 105 110
Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser
115 120 125
Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val
130 135 140
Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val
145 150 155 160
Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala
165 170 175
Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro
180 185 190
Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro
195 200 205
Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly
210 215 220
Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile
225 230 235 240
Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys
245 250 255
Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln
260 265 270
Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln
275 280 285
Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu
290 295 300
Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg
305 310 315 320
Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
325 330 335
Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro
340 345 350
Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr
355 360 365
Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln
370 375 380
Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly
385 390 395 400
Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu
405 410 415
Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn
420 425 430
His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys
435 440 445
<210> 1071
<211> 220
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> LakePharma变体 3, 4的VL
<400> 1071
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile
100 105 110
Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser
115 120 125
Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn
130 135 140
Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu
145 150 155 160
Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp
165 170 175
Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr
180 185 190
Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr
195 200 205
Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
210 215 220
<210> 1072
<211> 945
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56 蛋白的核苷酸序列
<400> 1072
atgacacgat taccaatact tttgttacta atatcattag tatacgctac accttttcct 60
cagacatcta aaaaaatagg tgatgatgca actctatcat gtaatcgaaa taatacaaat 120
gactacgttg ttatgagtgc ttggtataag gagcccaatt ctattattct tttagctgct 180
aaaagcgacg tcttgtattt tgataattat accaaggata aaatatctta cgactctcca 240
tacgatgatc tagttacaac tatcacaatt aaatcattga ctgctagaga tgccggtact 300
tatgtatgtg cattctttat gacatcgcct acaaatgaca ctgataaagt agattatgaa 360
gaatactcca cagagttgat tgtaaataca gatagtgaat cgactattga cataatacta 420
tctggatcta cacattcacc ggaaactagt tctgagaaac cagaggatat agataatttt 480
aattgctcgt cggtattcga aatcgcgact ccggaaccaa ttactgataa tgtagaagat 540
catacagaca ccgtcacata cactagtgat agcattaata cagtaagtgc atcatctgga 600
gaatccacaa cagacgagac tccggaacca attactgata aagaagaaga tcatacagtc 660
acagacactg tctcatacac tacagtaagt acatcatctg gaattgtcac tactaaatca 720
accaccgatg atgcggatct ttatgatacg tacaatgata atgatacagt accatcaact 780
actgtaggta gtagtacaac ctctattagc aattataaaa ccaaggactt tgtagaaata 840
tttggtatta ccgcattaat tatattgtcg gccgtggcaa tattctgtat tacgtattat 900
atatgtaata aacgttcacg taaatacaaa acagagaaca aagtc 945
<210> 1073
<211> 315
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56 蛋白的氨基酸序列
<400> 1073
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Thr Pro Phe Pro Gln Thr Ser Lys Lys Ile Gly Asp Asp Ala Thr Leu
20 25 30
Ser Cys Asn Arg Asn Asn Thr Asn Asp Tyr Val Val Met Ser Ala Trp
35 40 45
Tyr Lys Glu Pro Asn Ser Ile Ile Leu Leu Ala Ala Lys Ser Asp Val
50 55 60
Leu Tyr Phe Asp Asn Tyr Thr Lys Asp Lys Ile Ser Tyr Asp Ser Pro
65 70 75 80
Tyr Asp Asp Leu Val Thr Thr Ile Thr Ile Lys Ser Leu Thr Ala Arg
85 90 95
Asp Ala Gly Thr Tyr Val Cys Ala Phe Phe Met Thr Ser Pro Thr Asn
100 105 110
Asp Thr Asp Lys Val Asp Tyr Glu Glu Tyr Ser Thr Glu Leu Ile Val
115 120 125
Asn Thr Asp Ser Glu Ser Thr Ile Asp Ile Ile Leu Ser Gly Ser Thr
130 135 140
His Ser Pro Glu Thr Ser Ser Glu Lys Pro Glu Asp Ile Asp Asn Phe
145 150 155 160
Asn Cys Ser Ser Val Phe Glu Ile Ala Thr Pro Glu Pro Ile Thr Asp
165 170 175
Asn Val Glu Asp His Thr Asp Thr Val Thr Tyr Thr Ser Asp Ser Ile
180 185 190
Asn Thr Val Ser Ala Ser Ser Gly Glu Ser Thr Thr Asp Glu Thr Pro
195 200 205
Glu Pro Ile Thr Asp Lys Glu Glu Asp His Thr Val Thr Asp Thr Val
210 215 220
Ser Tyr Thr Thr Val Ser Thr Ser Ser Gly Ile Val Thr Thr Lys Ser
225 230 235 240
Thr Thr Asp Asp Ala Asp Leu Tyr Asp Thr Tyr Asn Asp Asn Asp Thr
245 250 255
Val Pro Ser Thr Thr Val Gly Ser Ser Thr Thr Ser Ile Ser Asn Tyr
260 265 270
Lys Thr Lys Asp Phe Val Glu Ile Phe Gly Ile Thr Ala Leu Ile Ile
275 280 285
Leu Ser Ala Val Ala Ile Phe Cys Ile Thr Tyr Tyr Ile Cys Asn Lys
290 295 300
Arg Ser Arg Lys Tyr Lys Thr Glu Asn Lys Val
305 310 315
<210> 1074
<211> 930
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白(OTS-412-A56) 的核苷酸序列
<400> 1074
atgacacgat taccaatact tttgttacta atatcattag tatacgctac accttttcct 60
cagacatcta aaaaaatagg tgatgatgca actctatcat gtaatcgaaa taatacaaat 120
gactacgttg ttatgagtgc ttggtataag gagcccaatt ctattattct tttagctgct 180
aaaagcgacg tcttgtattt tgataattat accaaggata aaatatctta cgactctcca 240
tacgatgatc tagttacaac tatcacaatt aaatcattga ctgctagaga tgccggtact 300
tatgtatgtg cattctttat gacatcgcct acaaatgaca ctgataaagt agattatgaa 360
gaatactcca cagagttgat tgtaaataca gatagtgaat cgactattga cataatacta 420
tctggatcta cacattcacc ggaaactagt tctgagaaac cagaggatat agataatttt 480
aattgctcgt cggtattcga aatcgcgact ccggaaccaa ttactgataa tgtagaagat 540
catacagaca ccgtcacata cactagtgat agcattaata cagtaagtgc atcatctgga 600
gaatccacaa cagacgagac tccggaacca attactgata aagaagaaga tcatacagtc 660
acagacactg tctcatacac tacagtaagt acatcatctg gaattgtcac tactaaatca 720
accaccgatg atgcgtacaa tgataatgat acagtaccat caactactgt aggtagtagt 780
acaacctcta ttagcaatta taaaaccaag gactttgtag aaatatttgg tattaccgca 840
ttaattatat tgtcggccgt ggcaatattc tgtattacgt attatatatg taataaacgt 900
tcacgtaaat acaaaacaga gaacaaagtc 930
<210> 1075
<211> 310
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白 (OTS-412-A56) 的氨基酸序列
<400> 1075
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Thr Pro Phe Pro Gln Thr Ser Lys Lys Ile Gly Asp Asp Ala Thr Leu
20 25 30
Ser Cys Asn Arg Asn Asn Thr Asn Asp Tyr Val Val Met Ser Ala Trp
35 40 45
Tyr Lys Glu Pro Asn Ser Ile Ile Leu Leu Ala Ala Lys Ser Asp Val
50 55 60
Leu Tyr Phe Asp Asn Tyr Thr Lys Asp Lys Ile Ser Tyr Asp Ser Pro
65 70 75 80
Tyr Asp Asp Leu Val Thr Thr Ile Thr Ile Lys Ser Leu Thr Ala Arg
85 90 95
Asp Ala Gly Thr Tyr Val Cys Ala Phe Phe Met Thr Ser Pro Thr Asn
100 105 110
Asp Thr Asp Lys Val Asp Tyr Glu Glu Tyr Ser Thr Glu Leu Ile Val
115 120 125
Asn Thr Asp Ser Glu Ser Thr Ile Asp Ile Ile Leu Ser Gly Ser Thr
130 135 140
His Ser Pro Glu Thr Ser Ser Glu Lys Pro Glu Asp Ile Asp Asn Phe
145 150 155 160
Asn Cys Ser Ser Val Phe Glu Ile Ala Thr Pro Glu Pro Ile Thr Asp
165 170 175
Asn Val Glu Asp His Thr Asp Thr Val Thr Tyr Thr Ser Asp Ser Ile
180 185 190
Asn Thr Val Ser Ala Ser Ser Gly Glu Ser Thr Thr Asp Glu Thr Pro
195 200 205
Glu Pro Ile Thr Asp Lys Glu Glu Asp His Thr Val Thr Asp Thr Val
210 215 220
Ser Tyr Thr Thr Val Ser Thr Ser Ser Gly Ile Val Thr Thr Lys Ser
225 230 235 240
Thr Thr Asp Asp Ala Tyr Asn Asp Asn Asp Thr Val Pro Ser Thr Thr
245 250 255
Val Gly Ser Ser Thr Thr Ser Ile Ser Asn Tyr Lys Thr Lys Asp Phe
260 265 270
Val Glu Ile Phe Gly Ile Thr Ala Leu Ile Ile Leu Ser Ala Val Ala
275 280 285
Ile Phe Cys Ile Thr Tyr Tyr Ile Cys Asn Lys Arg Ser Arg Lys Tyr
290 295 300
Lys Thr Glu Asn Lys Val
305 310
<210> 1076
<211> 774
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白 (WOTS-418-A56) 的氨基酸序列
<400> 1076
acaccttttc ctcagacatc taaaaaaata ggtgatgatg caactctatc atgtaatcga 60
aataatacaa atgactacgt tgttatgagt gcttggtata aggagcccaa ttctattatt 120
cttttagctg ctaaaagcga cgtcttgtat tttgataatt ataccaagga taaaatatct 180
tacgactctc catacgatga tctagttaca actatcacaa ttaaatcatt gactgctaga 240
gatgccggta cttatgtatg tgcattcttt atgacatcgc ctacaaatga cactgataaa 300
gtagattatg aagaatactc cacagagttg attgtaaata cagatagtga atcgactatt 360
gacataatac tatctggatc tacacattca ccggaaacta gttctgagaa accagaggat 420
atagataatt ttaattgctc gtcggtattc gaaatcgcga ctccggaacc aattactgat 480
aatgtagaag atcatacaga caccgtcaca tacactagtg atagcattaa tacagtaagt 540
gcatcatctg gagaatccac aacagacgag actccggaac caattactga taaagaagaa 600
gatcatacag tcacagacac tgtctcatac actacagtaa gtacatcatc tggaattgtc 660
actactaaat caaccaccga tgatgcgtac aatgataatg atacagtacc atcaactact 720
gtaggtagta gtacaacctc tattagcaat tataaaacca aggactttgt agaa 774
<210> 1077
<211> 258
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白片段 (OTS-412-A56) 的氨基酸序列
<400> 1077
Thr Pro Phe Pro Gln Thr Ser Lys Lys Ile Gly Asp Asp Ala Thr Leu
1 5 10 15
Ser Cys Asn Arg Asn Asn Thr Asn Asp Tyr Val Val Met Ser Ala Trp
20 25 30
Tyr Lys Glu Pro Asn Ser Ile Ile Leu Leu Ala Ala Lys Ser Asp Val
35 40 45
Leu Tyr Phe Asp Asn Tyr Thr Lys Asp Lys Ile Ser Tyr Asp Ser Pro
50 55 60
Tyr Asp Asp Leu Val Thr Thr Ile Thr Ile Lys Ser Leu Thr Ala Arg
65 70 75 80
Asp Ala Gly Thr Tyr Val Cys Ala Phe Phe Met Thr Ser Pro Thr Asn
85 90 95
Asp Thr Asp Lys Val Asp Tyr Glu Glu Tyr Ser Thr Glu Leu Ile Val
100 105 110
Asn Thr Asp Ser Glu Ser Thr Ile Asp Ile Ile Leu Ser Gly Ser Thr
115 120 125
His Ser Pro Glu Thr Ser Ser Glu Lys Pro Glu Asp Ile Asp Asn Phe
130 135 140
Asn Cys Ser Ser Val Phe Glu Ile Ala Thr Pro Glu Pro Ile Thr Asp
145 150 155 160
Asn Val Glu Asp His Thr Asp Thr Val Thr Tyr Thr Ser Asp Ser Ile
165 170 175
Asn Thr Val Ser Ala Ser Ser Gly Glu Ser Thr Thr Asp Glu Thr Pro
180 185 190
Glu Pro Ile Thr Asp Lys Glu Glu Asp His Thr Val Thr Asp Thr Val
195 200 205
Ser Tyr Thr Thr Val Ser Thr Ser Ser Gly Ile Val Thr Thr Lys Ser
210 215 220
Thr Thr Asp Asp Ala Tyr Asn Asp Asn Asp Thr Val Pro Ser Thr Thr
225 230 235 240
Val Gly Ser Ser Thr Thr Ser Ile Ser Asn Tyr Lys Thr Lys Asp Phe
245 250 255
Val Glu
<210> 1078
<211> 942
<212> DNA
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白 (WOTS-418-A56) 的核苷酸序列
<400> 1078
atgacacgat taccaatact tttgttacta atatcattag tatacgctac accttttcct 60
cagacatcta aaaaaatagg tgatgatgca actctatcat gtaatcgaaa taatacaaat 120
gactacgttg ttatgagtgc ttggtataag gagcccaatt ccattattct tttagctgct 180
aaaagcgacg tcttgtattt tgataattat accaaggata aaatatctta cgactctcca 240
tacgatgatc tagttacaac tatcacaatt aaatcattga ctgctagaga tgccggtact 300
tatgtatgtg cattctttat gacatcaact acaaatgaca ctgataaagt agattatgaa 360
gaatactcca cagagttgat tgtaaataca gatagtgaat cgactataga cataatacta 420
tctggatcta cacattcacc ggaaactagt tctaagaaac ctgattatat agataattct 480
aattgctcgt cggtattcga aatcgcgact ccggaaccaa ttactgataa tgtagaagat 540
catacagaca ccgtcacata cactagtgat agcattaata cagtaagtgc atcatctgga 600
gaatccacaa cagacgagac tccggaacca attactgata aagaagatca tacagttaca 660
gacactgtct catacactac agtaagtaca tcatctggaa ttgtcactac taaatcaacc 720
accgatgatg cggatcttta tgatacgtac aatgataatg atacagtacc accaactact 780
gtaggcggta gtacaacctc tattagcaat tataaaacca aggactttgt agaaatattt 840
ggtattaccg cattaattat attgtcggcc gtggcaattt tctgtattac atattatata 900
tataataaac gttcacgtaa atacaaaaca gagaacaaag tc 942
<210> 1079
<211> 314
<212> PRT
<213> 人工序列（Artificial Sequence）
<220>
<223> A56蛋白 (WOTS-418-A56) 的氨基酸序列
<400> 1079
Met Thr Arg Leu Pro Ile Leu Leu Leu Leu Ile Ser Leu Val Tyr Ala
1 5 10 15
Thr Pro Phe Pro Gln Thr Ser Lys Lys Ile Gly Asp Asp Ala Thr Leu
20 25 30
Ser Cys Asn Arg Asn Asn Thr Asn Asp Tyr Val Val Met Ser Ala Trp
35 40 45
Tyr Lys Glu Pro Asn Ser Ile Ile Leu Leu Ala Ala Lys Ser Asp Val
50 55 60
Leu Tyr Phe Asp Asn Tyr Thr Lys Asp Lys Ile Ser Tyr Asp Ser Pro
65 70 75 80
Tyr Asp Asp Leu Val Thr Thr Ile Thr Ile Lys Ser Leu Thr Ala Arg
85 90 95
Asp Ala Gly Thr Tyr Val Cys Ala Phe Phe Met Thr Ser Thr Thr Asn
100 105 110
Asp Thr Asp Lys Val Asp Tyr Glu Glu Tyr Ser Thr Glu Leu Ile Val
115 120 125
Asn Thr Asp Ser Glu Ser Thr Ile Asp Ile Ile Leu Ser Gly Ser Thr
130 135 140
His Ser Pro Glu Thr Ser Ser Lys Lys Pro Asp Tyr Ile Asp Asn Ser
145 150 155 160
Asn Cys Ser Ser Val Phe Glu Ile Ala Thr Pro Glu Pro Ile Thr Asp
165 170 175
Asn Val Glu Asp His Thr Asp Thr Val Thr Tyr Thr Ser Asp Ser Ile
180 185 190
Asn Thr Val Ser Ala Ser Ser Gly Glu Ser Thr Thr Asp Glu Thr Pro
195 200 205
Glu Pro Ile Thr Asp Lys Glu Asp His Thr Val Thr Asp Thr Val Ser
210 215 220
Tyr Thr Thr Val Ser Thr Ser Ser Gly Ile Val Thr Thr Lys Ser Thr
225 230 235 240
Thr Asp Asp Ala Asp Leu Tyr Asp Thr Tyr Asn Asp Asn Asp Thr Val
245 250 255
Pro Pro Thr Thr Val Gly Gly Ser Thr Thr Ser Ile Ser Asn Tyr Lys
260 265 270
Thr Lys Asp Phe Val Glu Ile Phe Gly Ile Thr Ala Leu Ile Ile Leu
275 280 285
Ser Ala Val Ala Ile Phe Cys Ile Thr Tyr Tyr Ile Tyr Asn Lys Arg
290 295 300
Ser Arg Lys Tyr Lys Thr Glu Asn Lys Val
305 310
Claims (24)
1.一种抗癌剂，其包含一活性成分：
特异性结合蛋白A56或其片段的抗体或其片段。
2.如权利要求1所述的抗癌剂，其中所述抗体或其片段包括：
重链可变区(VH)，包括选自下组的重链CDR1：
SEQ ID NO:1、18、35、52、69、86、103、120、137、154、171、188、205、222、239、256、273、290、307、324、341、358、375、392、409、426、443、460、477、494、511、528、545、562、579、596、613、630、647、664、681、698、715、732、749、766、783、800、817、834、851、868、885、902、919、936、953、970、987、1004、1021、1062、和1063；
选自下组的重链CDR2：
SEQ ID NO:2、19、36、53、70、87、104、121、138、155、172、189、206、223、240、257、274、291、308、325、342、359、376、393、410、427、444、461、478、495、512、529、546、563、580、597、614、631、648、665、682、699、716、733、750、767、784、801、818、835、852、869、886、903、920、937、954、971、988、1005、1022、和1064；和
选自下组的重链CDR3：
SEQ ID NO:3、20、37、54、71、88、105、122、139、156、173、190、207、224、241、258、275、292、309、326、343、360、377、394、411、428、445、462、479、496、513、530、547、564、581、598、615、632、649、666、683、700、717、734、751、768、785、802、819、836、853、870、887、904、921、938、955、972、989、1006、1023、和1065；和
轻链可变区(VL)，包括选自下组的轻链CDR1：
SEQ ID NO:4、21、38、55、72、89、106、123、140、157、174、191、208、225、242、259、276、293、310、327、344、361、378、395、412、429、446、463、480、497、514、531、548、565、582、599、616、633、650、667、684、701、718、735、752、769、786、803、820、837、854、871、888、905、922、939、956、973、990、1007、1024、和1066；
选自下组的轻链CDR2：
SEQ ID NO:5、22、39、56、73、90、107、124、141、158、175、192、209、226、243、260、277、294、311、328、345、362、379、396、413、430、447、464、481、498、515、532、549、566、583、600、617、634、651、668、685、702、719、736、753、770、787、804、821、838、855、872、889、906、923、940、957、974、991、1008、1025、和1067；和
选自下组的轻链CDR3：
SEQ ID NO:6、23、40、57、74、91、108、125、142、159、176、193、210、227、244、261、278、295、312、329、346、363、380、397、414、431、448、465、482、499、516、533、550、567、584、601、618、635、652、669、686、703、720、737、754、771、788、805、822、839、856、873、890、907、924、941、958、975、992、1009、1026、和1068。
3.如权利要求1所述的抗癌剂，其中所述的抗体或其片段包括：
重链可变区(VH)，包括具有SEQ ID NO:1、35、120、222、239、290、324、341、851、919、1062或1063所示的氨基酸序列的重链CDR1；
具有SEQ ID NO:2、36、121、223、240、291、325、342、852、920或1064所示的氨基酸序列的重链CDR2；和
具有SEQ ID NO:3、37、122、224、241、292、326、343、853、921或1065所示的氨基酸序列的重链CDR3；和
轻链可变区(VL)，包括具有SEQ ID NO:4、38、123、225、242、293、327、344、854、922或1066所示氨基酸序列的轻链CDR1；
具有SEQ ID NO:5、39、124、226、243、294、328、345、855、923或1067所示的氨基酸序列的轻链CDR2；和
具有SEQ ID NO:6、40、125、227、244、295、329、346、856、924或1068所示的氨基酸序列的轻链CDR3。
4.如权利要求1所述的抗癌剂，其中所述的抗癌剂靶向被溶瘤病毒感染的癌细胞。
5.如权利要求4所述的抗癌剂，其中所述的溶瘤病毒为牛痘病毒。
6.如权利要求5所述的抗癌剂，其中所述的溶瘤病毒包含编码蛋白A56或其片段的核酸。
7.如权利要求1所述的抗癌剂，其中所述的蛋白A56为野生型蛋白A56或蛋白A56的变体。
8.如权利要求1所述的抗癌剂，其中所述的蛋白A56或其片段包括SEQ ID NO:1038、1040、1042、1044、1046、1048、1050、1052、1054、1056、1058、1060、1073、1075、1077或1079所示的氨基酸序列。
9.如权利要求6所述的抗癌剂，其中所述编码蛋白A56或其片段的核酸包括SEQ ID NO:1039、1041、1043、1045、1047、1049、1051、1053、1055、1057、1059、1061、1072、1074、1076、或1078所示的核苷酸序列。
10.如权利要求1所述的抗癌剂，其中所述抗癌剂用于预防或治疗选自下组的癌症：肺癌、结直肠癌、前列腺癌、甲状腺癌、乳腺癌、脑癌、头颈癌、食道癌、皮肤癌、胸腺癌、胃癌、结肠癌、肝癌、卵巢癌、子宫癌、膀胱癌、直肠癌、胆囊癌、胆道癌、胰腺癌、淋巴瘤、急性白血病、多发性骨髓瘤或其组合。
11.一种溶瘤病毒，其包含：
编码蛋白A56或其片段的核酸。
12.如权利要求11所述的溶瘤病毒，其中所述的溶瘤病毒为牛痘病毒。
13.如权利要求11所述的溶瘤病毒，其中所述的蛋白A56为野生型蛋白A56或蛋白A56的变体。
14.如权利要求11所述的溶瘤病毒，其中所述编码蛋白A56或其片段的核酸包括SEQ IDNO:1039、1041、1043、1045、1047、1049、1051、1053、1055、1057、1059、1061、1072、1074、1076、或1078所示的核苷酸序列。
15.一种抗体或其片段，其结合蛋白A56或其片段。
16.如权利要求15所述的抗体或其片段，
所述抗体或其片段包括：
重链可变区(VH)，包括如SEQ ID NO:1、35、120、222、239、290、324、341、851、919、1062、或1063所示氨基酸序列的重链CDR1；
如SEQ ID NO:2、36、121、223、240、291、325、342、852、920、或1064所示氨基酸序列的重链CDR2；和
如SEQ ID NO:3、37、122、224、241、292、326、343、853、921、或1065所示氨基酸序列的重链CDR3：和
轻链可变区(VL)，包括如SEQ ID NO:4、38、123、225、242、293、327、344、854、922、或1066所示氨基酸序列的轻链CDR1；
如SEQ ID NO:5、39、124、226、243、294、328、345、855、923or 1067所示氨基酸序列的轻链CDR2；和
如SEQ ID NO:6、40、125、227、244、295、329、346、856、924、或1068所示氨基酸序列的轻链CDR3。
17.一种靶向癌症的多肽或其片段，所述多肽包括：
由SEQ ID NO:1038、1040、1042、1044、1046、1048、1050、1052、1054、1056、1058、1060、1073、1075、1077或1079所示的氨基酸序列。
18.一种分离的核酸，其编码如权利要求17所述的靶向癌症的多肽或其片段。
19.一种用于治疗癌症的试剂盒，包括：
如权利要求11所述的溶瘤病毒；和
如权利要求15所述的抗体或其片段。
20.一种用于靶向癌症的药物组合物，其包含：
如权利要求11所述的溶瘤病毒。
21.如权利要求11所述的溶瘤病毒在靶向癌症中的用途。
22.一种靶向癌症的方法，包含：
将如权利要求11所述的溶瘤病毒施用于个体的步骤。
23.如权利要求11所述的溶瘤病毒和如权利要求15所述的抗体或其片段的用途，用于治疗癌症。
24.一种治疗癌症的方法，包括步骤：
i)将如权利要求11所述的溶瘤病毒施用于个体；和
ii)如权利要求15所述的抗体或其片段施用于个体。
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| WO2024210531A1 (ko) * | 2023-04-03 | 2024-10-10 | 주식회사 셀랩메드 | 종양 용해성 바이러스 단백질-특이적 키메릭 항원 수용체 및 이의 용도 |
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| CN109069613A (zh) * | 2016-04-22 | 2018-12-21 | 瓦西尼斯公司 | 痘病毒胞外包膜病毒颗粒上的整合膜蛋白展示 |
| WO2019106205A1 (en) * | 2017-12-01 | 2019-06-06 | Gerd Sutter | Immuno-modulated replication-efficient vaccinia virus strain |
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| US7645456B2 (en) | 2001-04-23 | 2010-01-12 | Sanofi Pasteur Biologics Co. | Vaccinia virus strains |
| US20090098529A1 (en) * | 2006-10-16 | 2009-04-16 | Nanhai Chen | Methods for attenuating virus strains for diagnostic and therapeutic uses |
| CA2777744C (en) * | 2009-10-16 | 2019-09-24 | Bernard Moss | Recombinant modified vaccinia ankara (mva) vaccinia virus containing restructured insertion sites |
| WO2021040064A1 (ko) * | 2019-08-26 | 2021-03-04 | 주식회사 바이오녹스 | 백시니아 바이러스 및 히드록시유레아를 유효성분으로 포함하는 암 치료용 약학 조성물 |
| US20230027475A1 (en) | 2019-09-13 | 2023-01-26 | adMare Therapeutics Society | Anti-oncolytic virus antigen antibodies and methods of using same |
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| CN109069613A (zh) * | 2016-04-22 | 2018-12-21 | 瓦西尼斯公司 | 痘病毒胞外包膜病毒颗粒上的整合膜蛋白展示 |
| WO2019106205A1 (en) * | 2017-12-01 | 2019-06-06 | Gerd Sutter | Immuno-modulated replication-efficient vaccinia virus strain |
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| AU2020361337A1 (en) | 2022-03-31 |
| KR102550094B1 (ko) | 2023-07-04 |
| JP2022550667A (ja) | 2022-12-05 |
| WO2021066612A3 (ko) | 2021-05-27 |
| US20220389085A1 (en) | 2022-12-08 |
| EP4043482A4 (en) | 2024-03-13 |
| EP4043482A2 (en) | 2022-08-17 |
| KR20210039973A (ko) | 2021-04-12 |
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