CN114787160B - 作为活化素受体样激酶-2的抑制剂的咪唑并哒嗪和咪唑并吡啶化合物 - Google Patents

作为活化素受体样激酶-2的抑制剂的咪唑并哒嗪和咪唑并吡啶化合物 Download PDF

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CN114787160B
CN114787160B CN201980092367.1A CN201980092367A CN114787160B CN 114787160 B CN114787160 B CN 114787160B CN 201980092367 A CN201980092367 A CN 201980092367A CN 114787160 B CN114787160 B CN 114787160B
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methyl
alkyl
phenyl
alkylene
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CN114787160A (zh
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潘俊
J·罗奇
梅松
何春红
吴亮星
姚文清
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Incyte Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201980092367.1A 2018-12-20 2019-12-19 作为活化素受体样激酶-2的抑制剂的咪唑并哒嗪和咪唑并吡啶化合物 Active CN114787160B (zh)

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Application Number Priority Date Filing Date Title
CN202510176623.2A CN120208959A (zh) 2018-12-20 2019-12-19 作为活化素受体样激酶-2的抑制剂的咪唑并哒嗪和咪唑并吡啶化合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862782994P 2018-12-20 2018-12-20
US62/782,994 2018-12-20
US201962935891P 2019-11-15 2019-11-15
US62/935,891 2019-11-15
PCT/US2019/067403 WO2020132197A1 (en) 2018-12-20 2019-12-19 Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2

Related Child Applications (1)

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CN114787160B true CN114787160B (zh) 2025-03-25

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CN202510176623.2A Pending CN120208959A (zh) 2018-12-20 2019-12-19 作为活化素受体样激酶-2的抑制剂的咪唑并哒嗪和咪唑并吡啶化合物

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US (3) US11459329B2 (https=)
EP (1) EP3898627A1 (https=)
JP (2) JP7414827B2 (https=)
KR (1) KR20210116488A (https=)
CN (2) CN114787160B (https=)
AU (1) AU2019401649B2 (https=)
BR (1) BR112021011948A2 (https=)
CA (1) CA3124088A1 (https=)
CL (1) CL2021001656A1 (https=)
CO (1) CO2021008117A2 (https=)
CR (1) CR20210336A (https=)
EC (1) ECSP21044843A (https=)
IL (2) IL318278A (https=)
MA (1) MA54551A (https=)
MX (1) MX2021007426A (https=)
PE (1) PE20220277A1 (https=)
PH (1) PH12021551446A1 (https=)
SG (1) SG11202106582YA (https=)
TW (2) TWI852968B (https=)
WO (1) WO2020132197A1 (https=)

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CN114761013A (zh) 2019-09-27 2022-07-15 迪斯克医药公司 治疗骨髓纤维化和相关病症的方法
US12508262B2 (en) 2020-04-30 2025-12-30 Keros Therapeutics, Inc. Methods of using ALK2 inhibitors
WO2021231798A1 (en) 2020-05-13 2021-11-18 Disc Medicine, Inc. Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
CN115956081A (zh) 2020-06-12 2023-04-11 因赛特公司 具有作为alk2抑制剂的活性的咪唑并哒嗪化合物
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
CN118119619A (zh) * 2021-10-18 2024-05-31 上海美悦生物科技发展有限公司 Sik抑制剂及其组合物、制备方法和用途
KR20240078812A (ko) 2022-11-28 2024-06-04 계명대학교 산학협력단 신규한 pim 키나아제 억제제 및 이의 용도

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JP2024045155A (ja) 2024-04-02
JP2022514650A (ja) 2022-02-14
MA54551A (fr) 2021-10-27
CO2021008117A2 (es) 2021-09-20
JP7414827B2 (ja) 2024-01-16
ECSP21044843A (es) 2021-09-30
AU2019401649A1 (en) 2021-07-08
CL2021001656A1 (es) 2021-12-17
IL318278A (en) 2025-03-01
TW202039502A (zh) 2020-11-01
EP3898627A1 (en) 2021-10-27
US11459329B2 (en) 2022-10-04
WO2020132197A1 (en) 2020-06-25
CA3124088A1 (en) 2020-06-25
CN114787160A (zh) 2022-07-22
IL284139B2 (en) 2025-06-01
IL284139A (en) 2021-08-31
US12030889B2 (en) 2024-07-09
KR20210116488A (ko) 2021-09-27
IL284139B1 (en) 2025-02-01
TWI852968B (zh) 2024-08-21
MX2021007426A (es) 2021-09-08
US20240309008A1 (en) 2024-09-19
CN120208959A (zh) 2025-06-27
CR20210336A (es) 2021-12-06
JP7723068B2 (ja) 2025-08-13
US20220315595A1 (en) 2022-10-06
PH12021551446A1 (en) 2021-12-06
SG11202106582YA (en) 2021-07-29
PE20220277A1 (es) 2022-02-25
BR112021011948A2 (pt) 2021-09-08
TW202504901A (zh) 2025-02-01
US20200199131A1 (en) 2020-06-25
AU2019401649B2 (en) 2025-08-28

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