TWI852968B - 咪唑并嗒嗪及咪唑并吡啶化合物及其用途 - Google Patents

咪唑并嗒嗪及咪唑并吡啶化合物及其用途 Download PDF

Info

Publication number
TWI852968B
TWI852968B TW108146732A TW108146732A TWI852968B TW I852968 B TWI852968 B TW I852968B TW 108146732 A TW108146732 A TW 108146732A TW 108146732 A TW108146732 A TW 108146732A TW I852968 B TWI852968 B TW I852968B
Authority
TW
Taiwan
Prior art keywords
alkyl
alkylene
membered
independently selected
cycloalkyl
Prior art date
Application number
TW108146732A
Other languages
English (en)
Chinese (zh)
Other versions
TW202039502A (zh
Inventor
淳 潘
傑若米 洛奇
梅松
何春紅
吳亮星
文清 姚
Original Assignee
美商英塞特公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商英塞特公司 filed Critical 美商英塞特公司
Publication of TW202039502A publication Critical patent/TW202039502A/zh
Application granted granted Critical
Publication of TWI852968B publication Critical patent/TWI852968B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW108146732A 2018-12-20 2019-12-19 咪唑并嗒嗪及咪唑并吡啶化合物及其用途 TWI852968B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862782994P 2018-12-20 2018-12-20
US62/782,994 2018-12-20
US201962935891P 2019-11-15 2019-11-15
US62/935,891 2019-11-15

Publications (2)

Publication Number Publication Date
TW202039502A TW202039502A (zh) 2020-11-01
TWI852968B true TWI852968B (zh) 2024-08-21

Family

ID=69467674

Family Applications (2)

Application Number Title Priority Date Filing Date
TW108146732A TWI852968B (zh) 2018-12-20 2019-12-19 咪唑并嗒嗪及咪唑并吡啶化合物及其用途
TW113128182A TW202504901A (zh) 2018-12-20 2019-12-19 咪唑并嗒嗪及咪唑并吡啶化合物及其用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW113128182A TW202504901A (zh) 2018-12-20 2019-12-19 咪唑并嗒嗪及咪唑并吡啶化合物及其用途

Country Status (20)

Country Link
US (3) US11459329B2 (https=)
EP (1) EP3898627A1 (https=)
JP (2) JP7414827B2 (https=)
KR (1) KR20210116488A (https=)
CN (2) CN114787160B (https=)
AU (1) AU2019401649B2 (https=)
BR (1) BR112021011948A2 (https=)
CA (1) CA3124088A1 (https=)
CL (1) CL2021001656A1 (https=)
CO (1) CO2021008117A2 (https=)
CR (1) CR20210336A (https=)
EC (1) ECSP21044843A (https=)
IL (2) IL318278A (https=)
MA (1) MA54551A (https=)
MX (1) MX2021007426A (https=)
PE (1) PE20220277A1 (https=)
PH (1) PH12021551446A1 (https=)
SG (1) SG11202106582YA (https=)
TW (2) TWI852968B (https=)
WO (1) WO2020132197A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3124088A1 (en) * 2018-12-20 2020-06-25 Incyte Corporation Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2
CN114761013A (zh) 2019-09-27 2022-07-15 迪斯克医药公司 治疗骨髓纤维化和相关病症的方法
US12508262B2 (en) 2020-04-30 2025-12-30 Keros Therapeutics, Inc. Methods of using ALK2 inhibitors
WO2021231798A1 (en) 2020-05-13 2021-11-18 Disc Medicine, Inc. Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
CN115956081A (zh) 2020-06-12 2023-04-11 因赛特公司 具有作为alk2抑制剂的活性的咪唑并哒嗪化合物
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
CN118119619A (zh) * 2021-10-18 2024-05-31 上海美悦生物科技发展有限公司 Sik抑制剂及其组合物、制备方法和用途
KR20240078812A (ko) 2022-11-28 2024-06-04 계명대학교 산학협력단 신규한 pim 키나아제 억제제 및 이의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009013335A1 (en) * 2007-07-26 2009-01-29 Novartis Ag Organic compounds
WO2009050183A2 (en) * 2007-10-17 2009-04-23 Novartis Ag Imidazo [1, 2-a] pyridine derivatives useful as alk inhibitors
WO2018053126A1 (en) * 2016-09-14 2018-03-22 Vanderbilt University Inhibition of bmp signaling, compounds, compositions and uses thereof

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355653B1 (en) 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
SI1283839T1 (https=) 2000-05-26 2005-08-31 Schering Corp
ATE273695T1 (de) 2000-06-28 2004-09-15 Smithkline Beecham Plc Nassvermahlung
PE20030739A1 (es) 2001-11-30 2003-08-28 Schering Corp Antagonistas del receptor de adenosina a2a
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
JP2005343889A (ja) * 2004-05-06 2005-12-15 Taisho Pharmaceut Co Ltd イミダゾピリジン誘導体
ATE482213T1 (de) * 2004-11-04 2010-10-15 Vertex Pharma Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine
ME02372B (me) * 2006-11-22 2016-06-20 Incyte Holdings Corp Imidazotriazini i imidazopiramidini kao inhibitori kinaze
HUP0700395A2 (en) 2007-06-07 2009-03-02 Sanofi Aventis Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
EP3070090B1 (en) 2007-06-13 2018-12-12 Incyte Holdings Corporation Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
EP2453882A1 (en) * 2009-07-14 2012-05-23 Beth Israel Deaconess Medical Center, Inc. Methods of increasing liver proliferation
RS54824B1 (sr) 2010-05-21 2016-10-31 Incyte Holdings Corp Topikalna formulacija za inhibiciju jak-a
EP2598505B1 (en) * 2010-07-28 2015-03-18 Bayer Intellectual Property GmbH Substituted imidazo[1,2-b]pyridazines
EP2463289A1 (en) 2010-11-26 2012-06-13 Almirall, S.A. Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
CN103649093B (zh) 2011-05-06 2017-07-07 拜耳知识产权有限责任公司 取代的咪唑并吡啶和咪唑并哒嗪及其用途
KR102092988B1 (ko) * 2012-09-28 2020-03-25 벤더르빌트 유니버시티 선택성 bmp 저해제로써 융합된 헤테로 고리 화합물들
MX2015005375A (es) * 2012-11-07 2015-07-21 Hoffmann La Roche Compuestos de triazolo.
US9682983B2 (en) * 2013-03-14 2017-06-20 The Brigham And Women's Hospital, Inc. BMP inhibitors and methods of use thereof
EP3365340B1 (en) 2015-10-19 2022-08-10 Incyte Corporation Heterocyclic compounds as immunomodulators
US20170145025A1 (en) 2015-11-19 2017-05-25 Incyte Corporation Heterocyclic compounds as immunomodulators
ES2916874T3 (es) 2015-12-17 2022-07-06 Incyte Corp Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1
AU2016379372A1 (en) 2015-12-22 2018-08-02 Incyte Corporation Heterocyclic compounds as immunomodulators
ES2906460T3 (es) 2016-05-06 2022-04-18 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
ES2905980T3 (es) 2016-05-26 2022-04-12 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
BR112018076534A2 (pt) 2016-06-20 2019-04-02 Incyte Corporation compostos heterocíclicos como imunomoduladores
MA45669A (fr) 2016-07-14 2019-05-22 Incyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
EP3854796A1 (en) * 2016-08-17 2021-07-28 Children's Hospital Medical Center Imidazo[1,2-a]pyridine compounds, compositions comprising them, methods for treating diseases using them, and methods for preparing them
ES2941716T3 (es) 2016-08-29 2023-05-25 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
MX2019002951A (es) 2016-09-15 2019-09-11 Armstrong World Ind Inc Sistema de techo con movimiento aereo.
WO2018119286A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Bicyclic heteroaromatic compounds as immunomodulators
WO2018119263A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds derivatives as pd-l1 internalization inducers
ES2874756T3 (es) 2016-12-22 2021-11-05 Incyte Corp Derivados de triazolo[1,5-A]piridina como inmunomoduladores
ES2899402T3 (es) 2016-12-22 2022-03-11 Incyte Corp Derivados de piridina como inmunomoduladores
AU2017382870B2 (en) 2016-12-22 2022-03-24 Incyte Corporation Benzooxazole derivatives as immunomodulators
EP3558990B1 (en) 2016-12-22 2022-08-10 Incyte Corporation Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers
US20200054643A1 (en) 2017-01-18 2020-02-20 Vanderbilt University Fused heterocyclic compounds as selective bmp inhibitors
WO2018165569A1 (en) * 2017-03-10 2018-09-13 Rutgers, The State University Of New Jersey Therapeutic compounds and methods
CN109963854B (zh) 2017-03-16 2022-04-12 江苏恒瑞医药股份有限公司 杂芳基并[4,3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用
RU2019133646A (ru) * 2017-03-30 2021-04-30 Ф. Хоффманн-Ля Рош Аг Изохинолины в качестве ингибиторов hpk1
CU20200041A7 (es) 2017-10-24 2021-03-11 Bayer Ag Amidas de imidazopiridina sustituidas
BR122023024273A2 (pt) 2018-02-27 2024-02-20 Incyte Corporation Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos
CA3124088A1 (en) 2018-12-20 2020-06-25 Incyte Corporation Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2
CN115956081A (zh) 2020-06-12 2023-04-11 因赛特公司 具有作为alk2抑制剂的活性的咪唑并哒嗪化合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009013335A1 (en) * 2007-07-26 2009-01-29 Novartis Ag Organic compounds
WO2009050183A2 (en) * 2007-10-17 2009-04-23 Novartis Ag Imidazo [1, 2-a] pyridine derivatives useful as alk inhibitors
WO2018053126A1 (en) * 2016-09-14 2018-03-22 Vanderbilt University Inhibition of bmp signaling, compounds, compositions and uses thereof

Also Published As

Publication number Publication date
JP2024045155A (ja) 2024-04-02
JP2022514650A (ja) 2022-02-14
MA54551A (fr) 2021-10-27
CO2021008117A2 (es) 2021-09-20
JP7414827B2 (ja) 2024-01-16
ECSP21044843A (es) 2021-09-30
AU2019401649A1 (en) 2021-07-08
CL2021001656A1 (es) 2021-12-17
IL318278A (en) 2025-03-01
TW202039502A (zh) 2020-11-01
EP3898627A1 (en) 2021-10-27
US11459329B2 (en) 2022-10-04
WO2020132197A1 (en) 2020-06-25
CA3124088A1 (en) 2020-06-25
CN114787160A (zh) 2022-07-22
IL284139B2 (en) 2025-06-01
IL284139A (en) 2021-08-31
US12030889B2 (en) 2024-07-09
KR20210116488A (ko) 2021-09-27
IL284139B1 (en) 2025-02-01
MX2021007426A (es) 2021-09-08
US20240309008A1 (en) 2024-09-19
CN120208959A (zh) 2025-06-27
CR20210336A (es) 2021-12-06
JP7723068B2 (ja) 2025-08-13
US20220315595A1 (en) 2022-10-06
PH12021551446A1 (en) 2021-12-06
SG11202106582YA (en) 2021-07-29
PE20220277A1 (es) 2022-02-25
BR112021011948A2 (pt) 2021-09-08
TW202504901A (zh) 2025-02-01
CN114787160B (zh) 2025-03-25
US20200199131A1 (en) 2020-06-25
AU2019401649B2 (en) 2025-08-28

Similar Documents

Publication Publication Date Title
US12441731B2 (en) Pyrazolopyrimidine compounds and uses thereof
US12187725B2 (en) Tricyclic urea compounds as JAK2 V617F inhibitors
TWI852968B (zh) 咪唑并嗒嗪及咪唑并吡啶化合物及其用途
TWI895442B (zh) 咪唑并嗒嗪化合物及其用途
HK40057772A (en) Pyrazolo[4,3-d]pyrimidine compounds as alk2 and/or fgfr modulators
HK40057772B (en) Pyrazolo[4,3-d]pyrimidine compounds as alk2 and/or fgfr modulators
EA053050B1 (ru) Трициклические соединения мочевины в качестве ингибиторов jak2 v617f