CN114746413A - 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用 - Google Patents

二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用 Download PDF

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Publication number
CN114746413A
CN114746413A CN202080081812.7A CN202080081812A CN114746413A CN 114746413 A CN114746413 A CN 114746413A CN 202080081812 A CN202080081812 A CN 202080081812A CN 114746413 A CN114746413 A CN 114746413A
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compound
reaction
pharmaceutically acceptable
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acceptable salt
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CN114746413B (zh
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廖勇刚
钱文远
韦昌青
肖瑶
奚正英
张臣
黎健
陈曙辉
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Medshine Discovery Inc
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Medshine Discovery Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

式I所示的二氮杂吲哚类衍生物及其在制备与Chk1相关疾病的药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202080081812.7A 2019-11-29 2020-11-27 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用 Active CN114746413B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2019112063150 2019-11-29
CN201911206315 2019-11-29
CN202010790385 2020-08-07
CN2020107903851 2020-08-07
PCT/CN2020/132306 WO2021104461A1 (zh) 2019-11-29 2020-11-27 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用

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CN114746413A true CN114746413A (zh) 2022-07-12
CN114746413B CN114746413B (zh) 2024-02-23

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US (1) US11634424B2 (zh)
EP (1) EP4067351A4 (zh)
JP (1) JP7260718B2 (zh)
CN (1) CN114746413B (zh)
WO (1) WO2021104461A1 (zh)

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* Cited by examiner, † Cited by third party
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MX2023006364A (es) * 2020-11-30 2023-06-13 Sumitomo Pharma Co Ltd Derivado de 5-heteroaril-1h-pirazol-3-amina.
US11564920B2 (en) 2020-11-30 2023-01-31 Sumitomo Pharma Co., Ltd. 5-heteroaryl-1H-pyrazol-3-amine derivative
GB202213792D0 (en) 2022-09-21 2022-11-02 Benevolentai Bio Ltd New compounds and method

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WO2006021002A2 (en) * 2004-08-19 2006-02-23 Icos Corporation Compounds useful for inhibiting chk1
WO2009089042A1 (en) * 2008-01-09 2009-07-16 Signal Pharmaceuticals, Llc Pyrazole pyrazine amine compounds as kinase inhibitors, compositions thereof and methods of treatment therewith
CN102666544A (zh) * 2009-12-23 2012-09-12 默克专利有限公司 吡咯并[2，3-d]吡嗪-7-基嘧啶化合物
CN105524048A (zh) * 2014-08-19 2016-04-27 上海海和药物研究开发有限公司 作为fgfr激酶抑制剂的吲唑类化合物及其制备和应用
CN106170288A (zh) * 2014-02-10 2016-11-30 卡斯卡迪安疗法公司 药物化合物
CN107176951A (zh) * 2016-03-11 2017-09-19 恩瑞生物医药科技（上海）有限公司 一种脲类化合物、其制备方法及其医药用途
WO2018161871A1 (zh) * 2017-03-06 2018-09-13 罗欣生物科技（上海）有限公司 作为p53-MDM2抑制剂的咪唑并吡咯酮化合物
CN108601781A (zh) * 2016-02-04 2018-09-28 广州必贝特医药技术有限公司 作为检测点激酶1(chk1)抑制剂的3,5-二取代吡唑及其制备及应用
WO2019156438A1 (en) * 2018-02-07 2019-08-15 Korea Research Institute Of Chemical Technology Hetero ring-fused phenyl compounds for inhibiting tnik and medical uses thereof
CN112469718A (zh) * 2018-07-19 2021-03-09 南京明德新药研发有限公司 氮杂吲哚衍生物及其作为FGFR和C-Met抑制剂的应用
CN114057733A (zh) * 2020-08-07 2022-02-18 海思科医药集团股份有限公司 一种并环杂环衍生物及其在医药上的应用
CN116234551A (zh) * 2020-09-27 2023-06-06 南京明德新药研发有限公司 一类1,7-萘啶类化合物及其应用

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UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
CA2484209C (en) 2002-05-03 2013-06-11 Exelixis, Inc. Protein kinase modulators and methods of use
ES2309484T3 (es) 2003-01-09 2008-12-16 Pfizer Inc. Derivados de diazepinoindol como inhibidores de quinasa.
BRPI0412820A (pt) 2003-07-25 2006-09-26 Pfizer compostos de aminopirazol e utilização como inibidores de chk1
BRPI0418351A (pt) 2004-01-05 2007-05-08 Astrazeneca Ab composto ou um sal farmaceuticamente aceitável do mesmo, métodos de limitar a proliferação celular em um humano ou animal, de tratamento de um humano ou animal sofrendo de cáncer, de tratamento de profilaxia de cáncer, de tratamento de um humano ou animal sofrendo de uma doença neoplásica, de tratamento de um humano ou animal sofrendo de uma doença prolifetativa de tratamento de cáncer, para o tratamento de infecções associadas com cáncer, para o tratamento profilático de infecções associadas com cáncer, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, método de inibir a chk1 quinase, e, processo para a preparação de um composto ou um sal farmaceuticamente aceitável do mesmo
PA8850801A1 (es) * 2008-12-17 2010-07-27 Lilly Co Eli Compuestos útiles para inhibir chk1

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CN101115727A (zh) * 2004-08-19 2008-01-30 艾科斯有限公司 用于抑制chk1的化合物
WO2006021002A2 (en) * 2004-08-19 2006-02-23 Icos Corporation Compounds useful for inhibiting chk1
WO2009089042A1 (en) * 2008-01-09 2009-07-16 Signal Pharmaceuticals, Llc Pyrazole pyrazine amine compounds as kinase inhibitors, compositions thereof and methods of treatment therewith
CN102666544A (zh) * 2009-12-23 2012-09-12 默克专利有限公司 吡咯并[2，3-d]吡嗪-7-基嘧啶化合物
CN106170288A (zh) * 2014-02-10 2016-11-30 卡斯卡迪安疗法公司 药物化合物
CN105524048A (zh) * 2014-08-19 2016-04-27 上海海和药物研究开发有限公司 作为fgfr激酶抑制剂的吲唑类化合物及其制备和应用
CN108601781A (zh) * 2016-02-04 2018-09-28 广州必贝特医药技术有限公司 作为检测点激酶1(chk1)抑制剂的3,5-二取代吡唑及其制备及应用
CN107176951A (zh) * 2016-03-11 2017-09-19 恩瑞生物医药科技（上海）有限公司 一种脲类化合物、其制备方法及其医药用途
WO2018161871A1 (zh) * 2017-03-06 2018-09-13 罗欣生物科技（上海）有限公司 作为p53-MDM2抑制剂的咪唑并吡咯酮化合物
WO2019156438A1 (en) * 2018-02-07 2019-08-15 Korea Research Institute Of Chemical Technology Hetero ring-fused phenyl compounds for inhibiting tnik and medical uses thereof
CN112469718A (zh) * 2018-07-19 2021-03-09 南京明德新药研发有限公司 氮杂吲哚衍生物及其作为FGFR和C-Met抑制剂的应用
CN114057733A (zh) * 2020-08-07 2022-02-18 海思科医药集团股份有限公司 一种并环杂环衍生物及其在医药上的应用
CN116234551A (zh) * 2020-09-27 2023-06-06 南京明德新药研发有限公司 一类1,7-萘啶类化合物及其应用

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龙秀炳: "2-氨基噻唑/3-氨基吡唑类CHK1抑制剂的设计合成及生物活性评价", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》, no. 02, pages 079 - 73 *

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CN114746413B (zh) 2024-02-23
EP4067351A4 (en) 2023-11-22
WO2021104461A1 (zh) 2021-06-03
JP7260718B2 (ja) 2023-04-18
US11634424B2 (en) 2023-04-25
JP2022550215A (ja) 2022-11-30
US20230017858A1 (en) 2023-01-19
EP4067351A1 (en) 2022-10-05

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