CN114672559A - 癌症对通过pd-1阻断实现的免疫疗法响应的决定因素 - Google Patents
癌症对通过pd-1阻断实现的免疫疗法响应的决定因素 Download PDFInfo
- Publication number
- CN114672559A CN114672559A CN202210026426.9A CN202210026426A CN114672559A CN 114672559 A CN114672559 A CN 114672559A CN 202210026426 A CN202210026426 A CN 202210026426A CN 114672559 A CN114672559 A CN 114672559A
- Authority
- CN
- China
- Prior art keywords
- cancer
- immune checkpoint
- response
- mutation
- checkpoint modulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462083088P | 2014-11-21 | 2014-11-21 | |
| US62/083,088 | 2014-11-21 | ||
| US201562132381P | 2015-03-12 | 2015-03-12 | |
| US62/132,381 | 2015-03-12 | ||
| PCT/US2015/062208 WO2016081947A2 (en) | 2014-11-21 | 2015-11-23 | Determinants of cancer response to immunotherapy by pd-1 blockade |
| CN201580073049.2A CN107206064B (zh) | 2014-11-21 | 2015-11-23 | 癌症对通过pd-1阻断实现的免疫疗法响应的决定因素 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580073049.2A Division CN107206064B (zh) | 2014-11-21 | 2015-11-23 | 癌症对通过pd-1阻断实现的免疫疗法响应的决定因素 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114672559A true CN114672559A (zh) | 2022-06-28 |
Family
ID=56014697
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210026426.9A Pending CN114672559A (zh) | 2014-11-21 | 2015-11-23 | 癌症对通过pd-1阻断实现的免疫疗法响应的决定因素 |
| CN201580073049.2A Active CN107206064B (zh) | 2014-11-21 | 2015-11-23 | 癌症对通过pd-1阻断实现的免疫疗法响应的决定因素 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580073049.2A Active CN107206064B (zh) | 2014-11-21 | 2015-11-23 | 癌症对通过pd-1阻断实现的免疫疗法响应的决定因素 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20180291074A1 (enExample) |
| EP (2) | EP4393546A3 (enExample) |
| JP (4) | JP7173733B2 (enExample) |
| CN (2) | CN114672559A (enExample) |
| AU (3) | AU2015349644B2 (enExample) |
| CA (1) | CA2968059A1 (enExample) |
| HK (1) | HK1244440A1 (enExample) |
| MA (1) | MA40737A (enExample) |
| WO (1) | WO2016081947A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI729512B (zh) | 2008-12-09 | 2021-06-01 | 美商建南德克公司 | 抗pd-l1抗體及其於增進t細胞功能之用途 |
| PL3081576T3 (pl) | 2013-12-12 | 2020-03-31 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Przeciwciało anty pd-1, jego fragment wiążący antygen i ich zastosowanie medyczne |
| LT3212670T (lt) | 2014-10-29 | 2021-02-10 | Five Prime Therapeutics, Inc. | Kombinuotasis vėžio gydymas |
| MA40737A (fr) | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| CA3008641A1 (en) | 2015-12-16 | 2017-06-22 | Gritstone Oncology, Inc. | Neoantigen identification, manufacture, and use |
| JP2019505512A (ja) | 2016-01-08 | 2019-02-28 | バッシボディ アクスイェ セルスカプ | 治療用抗癌ネオエピトープワクチン |
| KR102500659B1 (ko) | 2016-02-29 | 2023-02-16 | 제넨테크, 인크. | 암에 대한 치료 및 진단 방법 |
| CN109476731A (zh) | 2016-02-29 | 2019-03-15 | 基础医药有限公司 | 治疗癌症的方法 |
| CN109069078A (zh) * | 2016-03-01 | 2018-12-21 | 北卡罗来纳州立大学 | 通过微针贴片辅助的递送增强癌症免疫疗法 |
| AU2017227308B2 (en) | 2016-03-02 | 2024-02-22 | Toray Industries, Inc. | Immunity inducer |
| TWI895621B (zh) | 2016-05-27 | 2025-09-01 | 美商艾吉納斯公司 | 抗-tim-3抗體及其使用方法 |
| WO2018003995A1 (ja) * | 2016-07-01 | 2018-01-04 | 国立大学法人東北大学 | 免疫チェックポイント阻害薬使用における免疫関連副作用の予測方法 |
| KR20190038935A (ko) | 2016-08-25 | 2019-04-09 | 난토믹스, 엘엘씨 | 면역요법 마커들 및 그 용도들(immunotherapy markers and uses therefor) |
| JP7579056B2 (ja) * | 2016-10-06 | 2024-11-07 | ジェネンテック, インコーポレイテッド | がんのための治療方法及び診断方法 |
| CA3039402A1 (en) | 2016-10-07 | 2018-04-12 | Omniseq, Inc. | Methods and systems for determining personalized therapies |
| WO2018132753A1 (en) * | 2017-01-13 | 2018-07-19 | Nantbio, Inc. | Validation of neoepitope-based treatment |
| US12331359B2 (en) | 2017-01-18 | 2025-06-17 | Michael Laessig | Neoantigens and uses thereof for treating cancer |
| US20190351039A1 (en) | 2017-02-01 | 2019-11-21 | Modernatx, Inc. | Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides |
| WO2018145023A1 (en) * | 2017-02-06 | 2018-08-09 | Novartis Ag | Method of predicting response to immunotherapy |
| EP3494235A1 (en) * | 2017-02-17 | 2019-06-12 | Stichting VUmc | Swarm intelligence-enhanced diagnosis and therapy selection for cancer using tumor- educated platelets |
| CN110651036A (zh) * | 2017-03-20 | 2020-01-03 | 健诺西生物科学公司 | 治疗方法 |
| CA3058175A1 (en) * | 2017-03-31 | 2018-10-04 | Bristol-Myers Squibb Company | Methods of treating tumor |
| GB201710815D0 (en) * | 2017-07-05 | 2017-08-16 | Francis Crick Inst Ltd | Method |
| AU2018304458B2 (en) * | 2017-07-21 | 2021-12-09 | Foundation Medicine, Inc. | Therapeutic and diagnostic methods for cancer |
| WO2019023624A1 (en) * | 2017-07-28 | 2019-01-31 | Bristol-Myers Squibb Company | PREDICTIVE PERIPHERAL BLOOD BIOMARKER FOR INHIBITORS OF CONTROL POINTS |
| KR20200051024A (ko) * | 2017-09-13 | 2020-05-12 | 파이브 프라임 테라퓨틱스, 인크. | 췌장암에 대한 조합 항-csf1r 및 항-pd-1 항체 조합 요법 |
| US20200268831A1 (en) * | 2017-09-15 | 2020-08-27 | The Texas A&M University System | Methods for enhancing immunotherapy in the treatment of cancer |
| CN117987553A (zh) * | 2017-09-25 | 2024-05-07 | 纪念斯隆凯特琳癌症中心 | 肿瘤突变负荷和检查点免疫疗法 |
| EP3691676A4 (en) * | 2017-10-02 | 2021-06-16 | Curematch, Inc. | METHOD FOR PREDICTING ANTIGENICITY AND / OR IMMUNOGENICITY OF A TUMOR-DERIVED NEO-PEPTIDE, USING MUTATIONAL SIGNATURE GROUNDS |
| WO2019075112A1 (en) | 2017-10-10 | 2019-04-18 | Gritstone Oncology, Inc. | IDENTIFICATION OF NEO-ANTIGENS USING HOT POINTS |
| WO2019075251A2 (en) * | 2017-10-12 | 2019-04-18 | Nantomics, Llc | CANCER SCORE FOR EVALUATION AND PREDICTION OF RESPONSE FROM BIOLOGICAL FLUIDS |
| JP2020536894A (ja) | 2017-10-15 | 2020-12-17 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 腫瘍処置法 |
| EP3704268B1 (en) | 2017-11-03 | 2025-01-22 | Guardant Health, Inc. | Normalizing tumor mutation burden |
| EP3710600B1 (en) * | 2017-11-17 | 2025-03-12 | GMDx Co Pty Ltd | Systems and methods for predicting the efficacy of cancer therapy |
| EP3714275A4 (en) | 2017-11-22 | 2021-10-27 | Gritstone bio, Inc. | REDUCTION OF JUNCTION EPITOPIC PRESENTATION FOR NEOANTIGENS |
| JP7299169B2 (ja) * | 2017-12-01 | 2023-06-27 | イルミナ インコーポレイテッド | 体細胞突然変異のクローン性を決定するための方法及びシステム |
| EP3788173B1 (en) * | 2018-05-03 | 2023-11-29 | F. Hoffmann-La Roche AG | Surrogate marker and method for tumor mutation burden measurement |
| JP2021522298A (ja) * | 2018-05-04 | 2021-08-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 癌治療のためのPD−1/PD−L1、TGFβおよびDNA−PKの同時阻害 |
| CA3107983A1 (en) | 2018-07-23 | 2020-01-30 | Guardant Health, Inc. | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
| EP3830296A1 (en) | 2018-07-27 | 2021-06-09 | F. Hoffmann-La Roche AG | Method of monitoring effectiveness of immunotherapy of cancer patients |
| JPWO2020045479A1 (ja) * | 2018-08-29 | 2021-08-12 | 公益財団法人東京都医学総合研究所 | HGF−regulated tyrosine kinase substrate(HGS)を標的とした抗腫瘍剤 |
| SG11202101400UA (en) | 2018-08-31 | 2021-03-30 | Guardant Health Inc | Microsatellite instability detection in cell-free dna |
| AU2019379167A1 (en) | 2018-11-15 | 2021-06-03 | Personal Genome Diagnostics Inc. | Method of improving prediction of response for cancer patients treated with immunotherapy |
| CN113194995A (zh) * | 2018-12-12 | 2021-07-30 | 免疫医疗有限责任公司 | 基于血液的肿瘤突变负荷预测非小细胞肺癌的总存活 |
| WO2020252456A1 (en) | 2019-06-14 | 2020-12-17 | The Trustees Of Columbia University In The City Of New York | Nt5c2 inhibitors for the treatment of chemotherapy-resistant acute lymphoblastic leukemia |
| EP4051314A4 (en) * | 2019-11-01 | 2023-12-06 | Memorial Sloan Kettering Cancer Center | HLA CLASS I SEQUENCE DIVERGENCE AND CANCER THERAPY |
| GB202003669D0 (en) * | 2020-03-13 | 2020-04-29 | Univ Oxford Innovation Ltd | Method for identifying neo-antigens |
| EP4143345A1 (en) * | 2020-04-28 | 2023-03-08 | Genentech, Inc. | Methods and compositions for non-small cell lung cancer immunotherapy |
| EP4158070A4 (en) * | 2020-06-01 | 2025-05-07 | GMDx Co Pty Ltd | METHODS FOR PREDICTING CANCER PROGRESSION |
| CN112309502B (zh) * | 2020-10-14 | 2024-09-20 | 深圳市新合生物医疗科技有限公司 | 一种计算肿瘤新抗原负荷的方法及系统 |
| WO2022099004A1 (en) * | 2020-11-06 | 2022-05-12 | The General Hospital Corporation | Methods for characterizing biological samples |
| US20240238340A1 (en) * | 2021-05-03 | 2024-07-18 | Rutgers, The State University Of New Jersey | Immunotherapy for inflammatory bowel disease and/or cancer |
| CN113030475B (zh) * | 2021-05-25 | 2021-08-10 | 泛肽生物科技(浙江)有限公司 | 一种基于细胞线粒体质量评估的t细胞pd-1检测方法 |
| CN113355424B (zh) * | 2021-07-14 | 2022-03-25 | 江苏先声医学诊断有限公司 | Pcdh11x突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用 |
| WO2024216165A1 (en) | 2023-04-12 | 2024-10-17 | Icahn School Of Medicine At Mount Sinai | Computational methods for selecting personalized neoantigen vaccines |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102905721A (zh) * | 2010-03-19 | 2013-01-30 | 伊玛提克斯生物技术有限公司 | 基于avl9的癌症的诊断及治疗 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040033497A1 (en) | 2002-08-13 | 2004-02-19 | Alarcon-Riquelme Marta E. | Polymorphisms of PD-1 |
| TWI477602B (zh) | 2006-02-09 | 2015-03-21 | Educational Foundation Jichi Medical Univ | Novel viral vector |
| CA2779843A1 (en) * | 2009-11-13 | 2011-05-19 | Infinity Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer |
| BR112012026227A2 (pt) * | 2010-04-13 | 2020-08-04 | Celldex Therapeutics, Inc. | anticorpo monoclonal humano ou humanizado, molécula biespecífica, vetor de expressão, célula transformada, composição, e, usos de um anticorpo |
| PT3023788T (pt) * | 2010-05-14 | 2020-05-18 | Massachusetts Gen Hospital | Composições de neoantigénios específicos de tumor para utilização no tratamento de tumores |
| US20130225433A1 (en) * | 2012-02-29 | 2013-08-29 | The Regents Of The Universitys Of Michagan | Prostate cancer markers and uses thereof |
| SG11201406592QA (en) | 2012-05-04 | 2014-11-27 | Pfizer | Prostate-associated antigens and vaccine-based immunotherapy regimens |
| ES2737757T3 (es) * | 2012-09-28 | 2020-01-15 | Univ Connecticut | Identificación de epítopos protectores contra tumores para el tratamiento de cánceres |
| SG10201805674YA (en) * | 2014-01-02 | 2018-08-30 | Memorial Sloan Kettering Cancer Center | Determinants of cancer response to immunotherapy |
| KR20170080697A (ko) * | 2014-11-13 | 2017-07-10 | 더 존스 홉킨스 유니버시티 | 관문 차단 및 미소부수체 불안정성 |
| MA40737A (fr) * | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
| CN117987553A (zh) * | 2017-09-25 | 2024-05-07 | 纪念斯隆凯特琳癌症中心 | 肿瘤突变负荷和检查点免疫疗法 |
-
2015
- 2015-11-22 MA MA040737A patent/MA40737A/fr unknown
- 2015-11-23 WO PCT/US2015/062208 patent/WO2016081947A2/en not_active Ceased
- 2015-11-23 AU AU2015349644A patent/AU2015349644B2/en active Active
- 2015-11-23 CN CN202210026426.9A patent/CN114672559A/zh active Pending
- 2015-11-23 HK HK18103939.8A patent/HK1244440A1/zh unknown
- 2015-11-23 CN CN201580073049.2A patent/CN107206064B/zh active Active
- 2015-11-23 US US15/528,385 patent/US20180291074A1/en not_active Abandoned
- 2015-11-23 CA CA2968059A patent/CA2968059A1/en active Pending
- 2015-11-23 EP EP24157218.9A patent/EP4393546A3/en active Pending
- 2015-11-23 JP JP2017527368A patent/JP7173733B2/ja active Active
- 2015-11-23 EP EP15861224.2A patent/EP3220950A4/en not_active Ceased
-
2019
- 2019-02-22 US US16/283,555 patent/US10993998B2/en active Active
-
2020
- 2020-08-11 JP JP2020135853A patent/JP2020196732A/ja not_active Withdrawn
-
2021
- 2021-03-15 US US17/202,173 patent/US12485162B2/en active Active
- 2021-08-09 AU AU2021215099A patent/AU2021215099A1/en not_active Abandoned
-
2022
- 2022-08-16 JP JP2022129458A patent/JP7550193B2/ja active Active
-
2024
- 2024-07-03 JP JP2024107117A patent/JP2024125234A/ja active Pending
- 2024-12-12 AU AU2024278364A patent/AU2024278364A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102905721A (zh) * | 2010-03-19 | 2013-01-30 | 伊玛提克斯生物技术有限公司 | 基于avl9的癌症的诊断及治疗 |
Non-Patent Citations (1)
| Title |
|---|
| ALEXANDRA SNYDER ET AL: "Genetic Basis for clinical response to CTLA-4 Blockade in Melanoma", 《NEW ENGLAND JOURNAL OF MEDICINE》, vol. 371, no. 23, 19 November 2014 (2014-11-19), pages 2189 - 2199, XP055262135, DOI: 10.1056/NEJMoa1406498 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4393546A3 (en) | 2024-12-11 |
| WO2016081947A4 (en) | 2016-09-09 |
| JP2024125234A (ja) | 2024-09-13 |
| JP2018502828A (ja) | 2018-02-01 |
| AU2021215099A1 (en) | 2021-08-26 |
| EP3220950A4 (en) | 2018-08-29 |
| WO2016081947A3 (en) | 2016-07-07 |
| AU2015349644A1 (en) | 2017-06-15 |
| MA40737A (fr) | 2017-07-04 |
| CA2968059A1 (en) | 2016-05-26 |
| JP2020196732A (ja) | 2020-12-10 |
| US20210308241A1 (en) | 2021-10-07 |
| US12485162B2 (en) | 2025-12-02 |
| AU2024278364A1 (en) | 2025-02-13 |
| CN107206064B (zh) | 2021-12-21 |
| US20180291074A1 (en) | 2018-10-11 |
| US20200040049A1 (en) | 2020-02-06 |
| HK1244440A1 (zh) | 2018-08-10 |
| JP7550193B2 (ja) | 2024-09-19 |
| JP2023055625A (ja) | 2023-04-18 |
| WO2016081947A2 (en) | 2016-05-26 |
| US10993998B2 (en) | 2021-05-04 |
| JP7173733B2 (ja) | 2022-11-16 |
| EP3220950A2 (en) | 2017-09-27 |
| AU2015349644B2 (en) | 2021-08-19 |
| EP4393546A2 (en) | 2024-07-03 |
| CN107206064A (zh) | 2017-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12485162B2 (en) | Determinants of cancer response to immunotherapy by pd-1 blockade | |
| Sayles et al. | Genome-informed targeted therapy for osteosarcoma | |
| RU2707530C2 (ru) | Детерминанты ответа раковой опухоли на иммунотерапию | |
| US20220340663A1 (en) | Tumor mutational load | |
| US11274342B2 (en) | Systems and methods for sequencing T cell receptors and uses thereof | |
| JP2020525030A (ja) | 癌の免疫療法への適合性を評価する方法 | |
| US20220389102A1 (en) | Hla class i sequence divergence and cancer therapy | |
| CN115135386A (zh) | 用于治疗胶质母细胞瘤的方法 | |
| HK40115175A (en) | Determinants of cancer response to immunotherapy by pd-1 blockade | |
| You et al. | Comprehensive Immune Landscape and Molecular Characteristics of Clinical Responses to Chemotherapy, Antiangiogenic Agents and PD-1 Inhibitors in Advanced Nasopharyngeal Cancer | |
| HK40032690A (en) | Tumor mutational load and checkpoint immunotherapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |