CN114586899A - Feed formula and method for promoting epidemic prevention medicament effect - Google Patents

Feed formula and method for promoting epidemic prevention medicament effect Download PDF

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Publication number
CN114586899A
CN114586899A CN202210255662.8A CN202210255662A CN114586899A CN 114586899 A CN114586899 A CN 114586899A CN 202210255662 A CN202210255662 A CN 202210255662A CN 114586899 A CN114586899 A CN 114586899A
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parts
feed
medicament
dregs
decoction
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方文军
岳耀辉
刘杰
郭新鹏
杜鹏
李希臣
岳远振
蔡桂玉
苗云清
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Weifang Yuyang Pharmaceutical Co ltd
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Weifang Yuyang Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/20—Animal feeding-stuffs from material of animal origin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/20—Animal feeding-stuffs from material of animal origin
    • A23K10/22—Animal feeding-stuffs from material of animal origin from fish
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486—Millettia
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
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    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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Abstract

The invention relates to a feed formula and a method for promoting the effect of an epidemic prevention medicament, which belong to the field of feed formulas and comprise the following steps: the chicken feed has the advantages that the chicken blood circulation is promoted mainly through the angelica and the salvia miltiorrhiza, the effect of epidemic prevention medicines is enhanced, the generation of the epidemic prevention medicines is accelerated, the chicken can quickly resist viruses, meanwhile, the leech, the magnolia officinalis and the caulis spatholobi can play an auxiliary role on the angelica and the salvia miltiorrhiza, the chicken blood circulation is enhanced, and the medicine effect is promoted.

Description

Feed formula and method for promoting epidemic prevention medicament effect
Technical Field
The invention relates to the field of feed formulas, in particular to a feed formula and a method for promoting the effect of an epidemic prevention medicament.
Background
Chickens, like humans, are living organisms, and humans need to be vaccinated at birth, as well as chickens, which need to be vaccinated. The chickens as poultry are more easily affected by virus infectious diseases, and the breeding quantity reaches more than one hundred chickens, and not only the infectious bronchitis vaccines but also the avian influenza vaccines and the newcastle vaccines need to be inoculated, and the vaccines are generally inoculated on 7 days and 17 days of the birth of the chickens.
However, some chickens are infected with diseases after being inoculated with the vaccine, the inoculated vaccine does not enable all chickens to generate antibodies, the absorption capacity and the digestion capacity of some chickens are weak, the antibody generation speed is slow, some chickens cannot generate effective antibodies, the risk of virus infection is increased, and meanwhile, the chickens can generate stress reactions such as diarrhea, fever and the like after being inoculated with the vaccine.
Therefore, a feed formula and a method capable of promoting the effect of an epidemic prevention medicament, reducing stress reaction and reducing the infection rate of chickens are urgently needed.
Disclosure of Invention
The invention aims to provide a feed formula and a method for promoting the effect of an epidemic prevention medicament, which can promote the effect of an epidemic prevention medicament, reduce stress reaction and reduce the infection rate of chickens.
The invention relates to a feed formula for promoting the effect of an epidemic prevention medicament, which is prepared from the following materials in parts by weight: comprises 5-20 parts of angelica; 4-26 parts of salvia miltiorrhiza; 1-5 parts of leech; 15-30 parts of codonopsis pilosula; 2-15 parts of bighead atractylodes rhizome; 3-12 parts of aloe; 20-50 parts of semen plantaginis; 8-23 parts of morinda officinalis; 8-12 parts of magnolia officinalis; 25-30 parts of caulis spatholobi; 20-30 parts of common andrographis herb; 0.001-0.003 part of mosapride; 0.002-0.008 part of ethylparaben; 0.001-0.006 part of sodium dodecyl sulfate; 0.003 to 0.009 part of polyvinyl alcohol; 50-300 parts of milk powder; 800 portions of water and 1500 portions of water; 1500 + 20000 parts of feed. The invention relates to a feed formula for promoting the effect of an epidemic prevention medicament, which is prepared from the following materials in parts by weight: 8-15 parts of angelica; 10-18 parts of salvia miltiorrhiza; 2-4 parts of leech; 20-25 parts of codonopsis pilosula; 5-13 parts of bighead atractylodes rhizome; 5-12 parts of aloe; 25-32 parts of semen plantaginis; 10-16 parts of morinda officinalis; 9-11 parts of magnolia officinalis; 27-29 parts of caulis spatholobi; 23-28 parts of common andrographis herb; 0.0012 to 0.0024 parts of mosapride; 0.003-0.006 part of ethylparaben; 0.002-0.004 portion of sodium dodecyl sulfate; 0.005-0.008 parts of polyvinyl alcohol; 80-200 parts of milk powder; 900 portions of water and 1400 portions; 19000 portions of feed 1800-.
The invention relates to a feed formula for promoting the effect of an epidemic prevention medicament, which is prepared from the following materials in parts by weight: 12 parts of angelica; 15 parts of salvia miltiorrhiza; 3 parts of leech; 23 parts of codonopsis pilosula; 8 parts of bighead atractylodes rhizome; 7 parts of aloe; 26 parts of semen plantaginis; 12 parts of morinda officinalis; 10 parts of magnolia officinalis; 28 parts of caulis spatholobi; 25 parts of common andrographis herb; 0.0018 part of mosapride; 0.005 part of ethylplatinum; 0.003 part of sodium dodecyl sulfate; 0.006 part of polyvinyl alcohol; 135 parts of milk powder; 1300 parts of water; 17500 parts of feed.
The invention relates to a feed formula for promoting the effect of an epidemic prevention medicament, wherein the traditional Chinese medicine formula is prepared according to the following modes:
step 1, preparing a first medicament and first dregs of a decoction: slicing radix Angelicae sinensis, Saviae Miltiorrhizae radix, radix Codonopsis, Atractylodis rhizoma, semen plantaginis, radix Morindae officinalis, and cortex Magnolia officinalis, cleaning, filtering, placing into a pot, adding 10 times of water, decocting with strong fire for 0.5 hr, decocting with slow fire for 1.5 hr, stopping fire, air drying to room temperature, and sieving with 100 mesh sieve to obtain first medicinal preparation and first residue.
Step 2, preparing a second medicament and second dregs of decoction: leech, aloe, caulis spatholobi and common andrographis herb are subjected to vacuum freeze drying sterilization and are placed into a pulverizer to be pulverized until the powder is sieved by a 100-mesh sieve to obtain first powder, the first powder is placed into an ultrasonic cell pulverizing extraction tank, distilled water with the weight 5 times that of the first powder is added into the ultrasonic cell pulverizing extraction tank, sodium dodecyl sulfate is added into the ultrasonic cell pulverizing extraction tank, ultrasonic treatment is carried out, the ultrasonic frequency is 3-6 times, and the ultrasonic power is 800W; taking out the materials after the ultrasonic treatment is finished, filtering to obtain a first filtrate and a first filter residue, adding distilled water with the same amount into the first filter residue, repeatedly carrying out ultrasonic treatment for 3-6 times with the ultrasonic power of 800W, taking out the materials after the ultrasonic treatment, filtering with a 200-mesh sieve to obtain a second filtrate and a second filter residue, mixing the first filtrate and the second filtrate, putting the mixture into a rotary evaporator, concentrating to obtain a second medicament, and mixing the first filter residue and the second filter residue to obtain a second medicament residue;
step 3, preparing a third medicament and third dregs of decoction: mixing and stirring the first medicament, the second medicament and polyvinyl alcohol for 20 minutes to obtain a third medicament, drying the first decoction dregs in the air, then putting the dried first decoction dregs into a crusher, crushing the first decoction dregs to a size of 100 meshes, putting the crushed first decoction dregs into a stirrer, adding the second decoction dregs, and stirring the mixture for 10 minutes to obtain third decoction dregs;
step 4, preparing a first preprocessed feed: adding the third medicament, mosapride and ethylplatinum into the feed, and putting the feed into a stirrer to stir for 40 minutes to obtain a first preprocessed feed;
step 5, preparing a second preprocessed feed: adding 10 times of water into the third decoction dregs, boiling the mixture in a steamer with strong fire, and putting the first preprocessed feed in the steamer in a waterproof mode for steaming for 30 minutes to obtain a second preprocessed feed;
step 6, preparing a final feed: adding milk powder into the second preprocessed feed and stirring for 20 minutes to prepare the final feed.
The feed formula for promoting the effect of the epidemic prevention medicament, disclosed by the invention, has the advantages that the ultrasonic treatment mode in the step 2 is that the extraction frequency is 40kHz, the extraction time is 15 minutes, and the extraction interval is 2 minutes each time.
The invention relates to a feed formula for promoting the effect of an epidemic prevention medicament and a method thereof, which are different from the prior art in that the feed formula for promoting the effect of the epidemic prevention medicament promotes the blood circulation of chickens mainly through angelica and salvia miltiorrhiza so that the epidemic prevention medicament can fully act, leech, magnolia officinalis and caulis spatholobi can play an auxiliary role on the angelica and the salvia miltiorrhiza so as to strengthen the blood circulation of chickens and promote the effect of the medicament, because the angelica, the salvia miltiorrhiza and leech can generate the side effects of sleepiness and gastrointestinal discomfort, in order to prevent the activity and food intake of chickens from being reduced, codonopsis pilosula and atractylodes macrocephala are added to treat the symptoms of sleepiness and gastrointestinal discomfort, because the magnolia officinalis and the caulis spatholobi can generate the symptoms of insufficient qi and blood and excessive internal heat, andrographis used to inhibit the side effects, and aloe and plantain seed are added to promote the metabolism of chickens so that the medicament can accelerate the effect, in order to relieve the side effect of plantain seed on the kidney, morinda officinalis is added to tonify the kidney, so that the side effect of plantain seed is inhibited, the western medicine mosapride is added, the gastrointestinal absorption can be promoted, the medicine can be absorbed more quickly and effectively, and meanwhile, the side effect of mosapride on the kidney can be inhibited through morinda officinalis and codonopsis pilosula. The invention can promote the blood circulation of the chicken and enhance the metabolism of the chicken by the formula so as to achieve the aim of quickly acting the epidemic prevention medicine and simultaneously play a role in inhibiting toxic and side effects generated by some medicines.
The feed formula and the method for promoting the effect of the epidemic prevention medicament are further explained by combining the attached drawings.
Drawings
FIG. 1 is a line graph comparing a comparative group and an example group of a feed formulation for promoting the action of an epidemic prevention agent.
Detailed Description
The invention relates to a feed formula for promoting the effect of an epidemic prevention medicament, which comprises the following components in part by weight: 5-20 parts of angelica; 4-26 parts of salvia miltiorrhiza; 1-5 parts of leech; 15-30 parts of codonopsis pilosula; 2-15 parts of bighead atractylodes rhizome; 3-12 parts of aloe; 20-50 parts of semen plantaginis; 8-23 parts of morinda officinalis; 8-12 parts of magnolia officinalis; 25-30 parts of caulis spatholobi; 20-30 parts of common andrographis herb; 0.001-0.003 part of mosapride; 0.002-0.008 part of ethylparaben; 0.001-0.006 part of sodium dodecyl sulfate; 0.003 to 0.009 part of polyvinyl alcohol; 50-300 parts of milk powder; 800 portions of water and 1500 portions of water; 1500 + 20000 parts of feed.
The invention mainly promotes the blood circulation of chicken by angelica and salvia miltiorrhiza, enables epidemic prevention medicines to fully act, enables antibodies to be rapidly generated, simultaneously adds leech, magnolia officinalis and caulis spatholobi to play an auxiliary role on the angelica and the salvia miltiorrhiza, strengthens the blood circulation of chicken, strengthens the generation of the antibodies, and enables the antibodies to keep activity for a long time, because the angelica, the salvia miltiorrhiza and the leech can generate the side effects of sleepiness and gastrointestinal discomfort, in order to prevent the activity and the food intake of the chicken from being reduced, the codonopsis pilosula and the atractylodes macrocephala are added to treat the symptoms of the sleepiness and the gastrointestinal discomfort, because the magnolia officinalis and the caulis spatholobi can generate the symptoms of deficiency of qi and blood and excessive internal heat, the andrographis used for inhibiting the side effects, and simultaneously adds aloe and the plantain seed to promote the metabolism of the chicken, so that toxic substances are rapidly discharged out of the body, and simultaneously enhances the metabolism to accelerate the generation of the antibodies, thereby effectively resisting viruses, in order to relieve the side effect of the plantain seeds on the kidney, morinda officinalis is added to tonify the kidney, so that the side effect of the plantain seeds is inhibited, the western medicine mosapride is added, the gastrointestinal absorption can be promoted, the absorption of the traditional Chinese medicine is quicker and more effective, and meanwhile, the side effect of the mosapride on the kidney can be inhibited through the morinda officinalis and the codonopsis pilosula. The invention can promote the blood circulation of the chicken and enhance the metabolism of the chicken through the formula, so as to achieve the effect of quickly generating antibodies and achieve the aim of quickly acting epidemic prevention medicines, and simultaneously play a role in inhibiting toxic and side effects generated by some medicines.
Description of the pharmacological Agents
Chinese angelica root: has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel, and relieving constipation, and can promote blood circulation of chicken, so that the chicken can produce antibody at a higher speed.
Red sage root: the radix salviae miltiorrhizae has the same blood circulation promoting effect as the angelica, can also remove blood stasis, has better effect of promoting blood circulation, can assist the angelica to enable the chicken to quickly generate antibodies, and can improve the effective time of the antibodies.
Leech: the medicine is called leech, and is derived from leech, leech or dried leech of Hirudinidae. It is salty, bitter and mild in nature and taste, with little toxicity, and enters liver meridian. The Chinese medicinal composition has the effects of breaking blood and freeing channels, removing stasis and eliminating mass, is used for treating blood stasis and amenorrhea, mass, hemiplegia due to apoplexy, traumatic injury and the like, has the same effects as the salvia miltiorrhiza and the angelica, can break blood and free channels, remove stasis and eliminate mass and can also promote the blood circulation of chickens and enhance the activity of antibodies, and the Chinese medicinal composition has salty taste and enters blood, bitter taste and smooth property and is specially used for liver channels.
Codonopsis pilosula: invigorating spleen and replenishing qi, quenching thirst, invigorating spleen and lung, nourishing blood, and promoting fluid production. Codonopsis pilosula is sweet in flavor and neutral in nature. Has effects in invigorating spleen, replenishing qi, quenching thirst, invigorating spleen, benefiting lung, nourishing blood, and promoting salivation. The traditional Chinese medicine composition is used for treating diseases such as deficiency of lung and spleen qi, poor appetite and lassitude, cough and dyspnea due to deficiency of qi and blood, sallow complexion, palpitation and shortness of breath, body fluid deficiency and thirst, internal heat and diabetes and the like, and can effectively treat somnolence caused by angelica, thereby preventing chickens from eating less due to somnolence.
White atractylodes rhizome: eliminating dampness, eliminating turbid pathogen, relieving pain, inducing diuresis to alleviate edema, tranquilizing mind, and nourishing fetus. The largehead atractylodes rhizome is bitter in property and bitter in taste, is warm and pungent, has the effects of drying dampness, dissolving turbidity and relieving pain, can effectively treat gastrointestinal diseases caused by the red sage root, the leech and the aloe, and can prevent the side effect of diarrhea after the chicken eat the medicine.
Aloe vera: purging pathogenic fire, removing toxic substances, removing blood stasis, and killing parasites. Aloe is bitter in flavor and dry in nature, and enters lung meridian and large intestine meridian mainly. It has the functions of purging fire, detoxicating, dispersing blood clots, killing pests and strengthening chicken's metabolism and thus raising chicken's resistance.
Plantain seed: has effects in clearing away heat, promoting urination, eliminating dampness, treating stranguria, improving eyesight, eliminating phlegm, and relieving joint tension.
Morinda officinalis: invigorating kidney and strengthening yang. The morinda officinalis is a kidney tonifying agent, has the effects of warming kidney and replenishing vital essence, strengthening tendons and bones, and can dispel rheumatism, is mainly used for treating impotence, premature ejaculation, frequent micturition and enuresis of male patients caused by kidney-yang deficiency, and treating soreness and weakness of waist and knees, irregular menstruation, small menstrual flow, blood clots, rheumatic arthralgia and the like of female patients, can treat kidney cold deficiency caused by the plantain seed, and prevents the kidney from being damaged by the consumption of the plantain seed by chickens, so that the life of the chickens is influenced.
Magnolia officinalis: the Chinese medicinal composition has the effects of strengthening spleen, helping digestion, descending qi, relieving epigastric distention, eliminating dampness and eliminating phlegm, and can ensure that chickens can digest quickly after eating the feed with the Chinese medicinal composition and the Chinese medicinal composition reaches blood quickly.
Caulis spatholobi: warm in nature and pungent in taste, has the effects of nourishing blood, promoting blood circulation, relaxing tendons, activating collaterals and assisting the angelica, the salvia miltiorrhiza and the leech to play a role in promoting blood circulation.
Andrographis paniculata: has the functions of clearing away heat and toxic material, diminishing inflammation, eliminating swelling and relieving pain, and can well inhibit the side effect of excessive internal heat caused by caulis spatholobi.
Mosapride: mosapride is a drug, which is a selective 5-hydroxytryptamine 4(5-HT4) receptor agonist and can promote the release of acetylcholine and stimulate gastrointestinal tract to exert an actuating force, thereby improving gastrointestinal symptoms of patients with functional dyspepsia, but not affecting gastric acid secretion.
Ethylplatinum: has stronger bacteriostatic effect on fungi but weaker bacteriostatic effect on bacteria. The antibacterial preservative is widely used for liquid preparations and semi-solid preparations, can also be used for preserving foods and cosmetics, and mainly has the functions of sterilization and disinfection in the formula.
Sodium lauryl sulfate: an anionic surfactant has good emulsifiability, water solubility and biodegradability, and can be widely applied to the fields of pharmacy, cosmetics, lubrication, detergents and the like. The emulsifier is used as an emulsifier in the pharmaceutical field, and plays a role in increasing the surface activity of the medicine and promoting the extraction of the medicine in the formula.
Polyvinyl alcohol: the high molecular organic matter is a safe high molecular organic matter, has no toxicity and side effect on human body, has good biocompatibility, is especially widely applied to the aspects of ophthalmology, wound dressing and artificial joint in medical treatment such as water gel, is a common safe film forming agent, can enable the extracted medicine to have viscosity, can be adsorbed on feed, and cannot enable the medicine to lose along with water.
Milk powder: the milk powder is rich in protein, vitamins and various minerals. Has good effect on improving the resistance of chicken, because the immune globulin contained in the milk powder is mainly used for improving the resistance. The milk powder contains various growth factors, and is helpful for chicken development.
Wherein, the feed can be composed of 44% of corn, 15% of bean cake, 1.5% of stone powder, 1.1% of calcium hydrophosphate, 0.05% of methionine, 0.05% of lysine, 0.8% of premix, 1.5% of fish meal, 10% of sorghum, 10% of flour, 8% of peanut cake and 8% of wheat bran, the feed proportion is only an example, and the formula is applicable to any feed.
In the invention, the salvia miltiorrhiza and the angelica mainly play a role in promoting blood circulation, and have a large proportion, so that the salvia miltiorrhiza and the angelica are monarch. Leech, magnolia officinalis, caulis spatholobi, aloe and plantain seed can assist the salvia miltiorrhiza and angelica to promote blood circulation and metabolism, and the leech, magnolia officinalis, caulis spatholobi, aloe and plantain seed are ministerial drugs. The semen plantaginis, the bighead atractylodes rhizome and the common andrographis herb can play a role in inhibiting lethargy, gastrointestinal discomfort, excessive internal heat and deficiency of qi and blood generated by the salvia miltiorrhiza, the angelica, the leech, the magnolia officinalis, the suberect spatholobus stem, the aloe and the semen plantaginis, and are used as assistants. The radix Codonopsis has effects of invigorating qi, replenishing blood, promoting blood circulation, and promoting epidemic prevention medicine while inhibiting lethargy and intestine and stomach discomfort caused by Saviae Miltiorrhizae radix and radix Angelicae sinensis.
As a preferable proportioning mode: a feed formula for promoting the effect of an epidemic prevention medicament comprises the following materials in parts by weight: 8-15 parts of angelica; 10-18 parts of salvia miltiorrhiza; 2-4 parts of leech; 20-25 parts of codonopsis pilosula; 5-13 parts of bighead atractylodes rhizome; 5-12 parts of aloe; 25-32 parts of semen plantaginis; 10-16 parts of morinda officinalis; 9-11 parts of magnolia officinalis; 27-29 parts of caulis spatholobi; 23-28 parts of common andrographis herb; 0.0012 to 0.0024 parts of mosapride; 0.003-0.006 part of ethylparaben; 0.002-0.004 portion of sodium dodecyl sulfate; 0.005-0.008 parts of polyvinyl alcohol; 80-200 parts of milk powder; 900 portions of water and 1400 portions of water; 19000 portions of feed 1800-.
The invention can further increase the curative effect by optimizing the proportion of the components, promote blood circulation, enhance metabolism and simultaneously minimize the side effect brought by the medicines, so that the medicines can supplement each other.
As a preferable proportioning mode: a feed formula for promoting the effect of an epidemic prevention medicament comprises the following materials in parts by weight: 12 parts of angelica; 15 parts of salvia miltiorrhiza; 3 parts of leech; 23 parts of codonopsis pilosula; 8 parts of bighead atractylodes rhizome; 7 parts of aloe; 26 parts of semen plantaginis; 12 parts of morinda officinalis; 10 parts of magnolia officinalis; 28 parts of caulis spatholobi; 25 parts of common andrographis herb; 0.0018 part of mosapride; 0.005 part of ethylplatine; 0.003 part of sodium dodecyl sulfate; 0.006 part of polyvinyl alcohol; 135 parts of milk powder; 1300 parts of water; 17500 parts of feed.
The feed is optimized through the proportion of the components, the dosage is the most balanced proportion, the main treatment effect of the angelica and the salvia miltiorrhiza can be ensured, the probability of generating toxic and side effects can be reduced through the most reasonable proportion of the traditional Chinese medicines, and the feeding frequency suggests that the chicken are fed half an hour before the epidemic prevention medicines are taken.
The invention relates to a feed formula for promoting the effect of an epidemic prevention medicament, which is prepared from the following traditional Chinese medicine formula in the following way:
step 1, preparing a first medicament and first dregs of a decoction: slicing radix Angelicae sinensis, Saviae Miltiorrhizae radix, radix Codonopsis, Atractylodis rhizoma, semen plantaginis, radix Morindae officinalis, and cortex Magnolia officinalis, cleaning, filtering, placing into a pot, adding 10 times of water, decocting with strong fire for 0.5 hr, decocting with slow fire for 1.5 hr, stopping fire, air drying to room temperature, and sieving with 100 mesh sieve to obtain first medicinal preparation and first residue.
Wherein the step of slicing the angelica, the salvia miltiorrhiza, the codonopsis pilosula, the atractylodes macrocephala, the plantain seed, the morinda officinalis and the magnolia officinalis comprises the step of cutting the angelica, the salvia miltiorrhiza, the codonopsis pilosula, the atractylodes macrocephala, the plantain seed, the morinda officinalis and the magnolia officinalis into slices with the thickness of 3 mm.
Wherein, the step of filtering after cleaning and putting in the pot comprises the following steps: adding 3.5 times of water into the sliced angelica, the salvia miltiorrhiza, the codonopsis pilosula, the bighead atractylodes rhizome, the plantain seed, the morinda officinalis and the mangnolia officinalis, placing the mixture into a stirrer, and stirring the mixture for 15 minutes clockwise and 15 minutes anticlockwise.
Step 2, preparing a second medicament and second dregs of decoction: vacuum freeze-drying and sterilizing leeches, aloes, caulis spatholobi and andrographis paniculata, putting the leeches, aloes, caulis spatholobi and andrographis paniculata into a pulverizer, pulverizing the leeches, the aloes, the caulis spatholobi and the andrographis paniculata into a 100-mesh sieve to obtain first powder, putting the first powder into an ultrasonic cell pulverizing and extracting tank, adding distilled water which is 5 times the weight of the first powder into the ultrasonic cell pulverizing and extracting tank, adding sodium dodecyl sulfate into the ultrasonic cell pulverizing and extracting tank, and performing ultrasonic treatment for 3-6 times with the ultrasonic power of 800W; taking out the materials after the ultrasonic treatment is finished, filtering to obtain a first filtrate and a first filter residue, adding distilled water with the same amount into the first filter residue, repeating the ultrasonic treatment for one time, wherein the ultrasonic frequency is 3-6 times, the ultrasonic power is 800W, taking out the materials after the ultrasonic treatment, filtering with a 200-mesh sieve to obtain a second filtrate and a second filter residue, mixing the first filtrate and the second filtrate, putting the mixture into a rotary evaporator, concentrating to obtain a second medicament, and mixing the first filter residue and the second filter residue to obtain a second medicament residue;
according to the invention, leech, aloe, caulis spatholobi and andrographis paniculata are frozen, sterilized and crushed for ultrasonic extraction, so that the method can prevent some effective components of the medicine from being broken quickly due to overhigh temperature, meanwhile, more limited components can be extracted by ultrasonic extraction, the medicine property can be well maintained, and the surfactant sodium dodecyl sulfate is added during ultrasonic extraction, so that the activity of the effective components in the medicine can be enhanced, and the extraction rate is improved.
Wherein "the same amount of distilled water" is: 5 times the weight of distilled water of the first powder.
Wherein, rubbing crusher's brand does: the royal, the model is: 800Y.
Wherein, the brand of supersound cell crushing extraction jar is: the type of the net mail is as follows: SK2200H, using an extraction frequency of 40kHz, an extraction time of 15 minutes, with an interval of 2 minutes for each extraction.
Step 3, preparing a third medicament and third dregs of decoction: mixing and stirring the first medicament, the second medicament and polyvinyl alcohol for 20 minutes to obtain a third medicament, drying the first decoction dregs in the air, then putting the dried first decoction dregs into a crusher, crushing the first decoction dregs to a size of 100 meshes, putting the crushed first decoction dregs into a stirrer, adding the second decoction dregs, and stirring the mixture for 10 minutes to obtain third decoction dregs;
according to the invention, the adhesive polyvinyl alcohol is added into the first medicament and the second medicament, so that the medicaments can be adsorbed on the feed and cannot be excessively lost.
Wherein, the brand of the stirrer is permanent mechanical, the power is 4KW, and the name is 200kg stainless steel stirrer.
Step 4, preparing a first preprocessed feed: adding the third agent, mosapride and ethylplatinum into the feed, and placing the feed into a stirrer to stir for 40 minutes to obtain a first preprocessed feed;
the third medicament is added into the feed, so that the traditional Chinese medicines for promoting the effect of the epidemic prevention medicines are eaten by the chickens, the flavor of the feed can cover the taste of most traditional Chinese medicines, the ethylparaben is added to achieve a good antibacterial effect, and the mosapride is added to promote the digestion of the chickens, so that the medicine effect is fully digested and absorbed into blood, and the medicine effect is improved.
Step 5, preparing a second preprocessed feed: adding 10 times of water into the third decoction dregs, boiling the mixture in a steamer with strong fire, and putting the first preprocessed feed in the steamer in a waterproof mode for steaming for 30 minutes to obtain a second preprocessed feed;
according to the invention, the residue is used for steaming the stirred feed, so that the residual effective components of the medicine in the residue can be volatilized into the feed along with the steam, the medicine property of the medicine can be effectively increased, and the curative effect of the formula is improved.
Wherein, the water level that 10 times weight is added to the third dregs of a decoction is located the lower floor of steamer baffle, and first preprocessing fodder is located the upper strata of steamer baffle.
Step 6, preparing a final feed: adding milk powder into the second preprocessed feed and stirring for 20 minutes to prepare the final feed.
The milk powder is added after the water-proof steaming, so that the milk powder can be effectively mixed in the feed, and the milk powder can not drop down after being dissolved in water along with the fumigation of water vapor.
Wherein, the milk powder manufacturer is known fishery creature, and the product model is as follows: 25 kg/bag.
The invention slices and then decocts angelica, salvia miltiorrhiza, radix codonopsitis, atractylodes, plantain seed, morinda officinalis and magnolia officinalis, can decoct the active ingredients in the medicine, and exert the maximum efficacy of the medicine, freeze-dries leech, aloe, caulis spatholobi and andrographis paniculata, grinds the leech, aloe, caulis spatholobi and andrographis paniculata, adds distilled water for ultrasonic treatment, collects the extract, can directly separate the target component from the matrix because the ultrasonic wave can selectively heat different components in the extract, thereby improving the extraction efficiency and the product purity, and further improving the efficacy, carries out ultrasonic treatment twice, can exert the efficacy in the leech, aloe, caulis spatholobi and andrographis paniculata extremely, adds polyvinyl alcohol into the first medicament and the second medicament for mixing, can make the medicaments viscous and mix with the feed, thereby better adhering the medicaments on the feed, mixes the dregs generated by manufacturing the first medicament and the second medicament as third dregs, the water is added for boiling, so that the water vapor steams the feed, and the residual medicine in the medicine residue is brought to the feed along with the evaporation of the water, thereby exerting the maximum medicine effect.
Experimental data
The method for directly administering the drug and feeding the formula to the chickens is characterized in that 600 chickens are randomly distributed into 6 groups, each group of 100 chickens which are not treated with the epidemic prevention drug are administered, and the experimental data are as follows:
comparative group 1:
the group of chickens adopt a method that the chickens are not fed with any medicine before the epidemic prevention medicine is applied, blood is drawn after 2 days, the antibody titer reaches 72 of the chickens, 8 of the chickens are diarrhea, 10 of the chickens are anorexia the next day, and 9 of the chickens are pecked.
The preparation method of comparative group 2 was:
step 1, preparing a first medicament and first dregs of a decoction: slicing radix Angelicae sinensis, Saviae Miltiorrhizae radix, radix Codonopsis, Atractylodis rhizoma, semen plantaginis, radix Morindae officinalis, and cortex Magnolia officinalis, cleaning, filtering, placing into a pot, adding 10 times of water, decocting with strong fire for 0.5 hr, decocting with slow fire for 1.5 hr, stopping fire, air drying to room temperature, and sieving with 100 mesh sieve to obtain first medicinal preparation and first residue.
Step 2, preparing a second medicament and second dregs of decoction: leech, aloe, caulis spatholobi and common andrographis herb are subjected to vacuum freeze drying sterilization and are placed into a pulverizer to be pulverized until the powder is sieved by a 100-mesh sieve to obtain first powder, the first powder is placed into an ultrasonic cell pulverizing extraction tank, distilled water with the weight 5 times that of the first powder is added into the ultrasonic cell pulverizing extraction tank, sodium dodecyl sulfate is added into the ultrasonic cell pulverizing extraction tank, ultrasonic treatment is carried out, the ultrasonic frequency is 3-6 times, and the ultrasonic power is 800W; taking out the materials after the ultrasonic treatment is finished, filtering to obtain a first filtrate and a first filter residue, adding distilled water with the same amount into the first filter residue, repeatedly carrying out ultrasonic treatment for 3-6 times with the ultrasonic power of 800W, taking out the materials after the ultrasonic treatment, filtering with a 200-mesh sieve to obtain a second filtrate and a second filter residue, mixing the first filtrate and the second filtrate, putting the mixture into a rotary evaporator, concentrating to obtain a second medicament, and mixing the first filter residue and the second filter residue to obtain a second medicament residue;
step 3, preparing a third medicament and third dregs of decoction: mixing and stirring the first medicament, the second medicament and polyvinyl alcohol for 20 minutes to obtain a third medicament, drying the first decoction dregs in the air, then putting the dried first decoction dregs into a crusher, crushing the first decoction dregs to a size of 100 meshes, putting the crushed first decoction dregs into a stirrer, adding the second decoction dregs, and stirring the mixture for 10 minutes to obtain third decoction dregs;
step 4, preparing a first preprocessed feed: adding the third medicament, mosapride and ethylplatinum into the feed, and putting the feed into a stirrer to stir for 40 minutes to obtain a first preprocessed feed;
step 5, preparing a second preprocessed feed: adding 10 times of water into the third decoction dregs, boiling the mixture in a steamer with strong fire, and putting the first preprocessed feed in the steamer in a waterproof mode for steaming for 30 minutes to obtain a second preprocessed feed;
step 6, preparing a final feed: adding milk powder into the second preprocessed feed and stirring for 20 minutes to prepare the final feed.
Comparative group 2:
12 parts of angelica; 15 parts of salvia miltiorrhiza; 3 parts of leech; 15 parts of codonopsis pilosula; 6 parts of bighead atractylodes rhizome; 7 parts of aloe; 15 parts of semen plantaginis; 8 parts of morinda officinalis; 10 parts of magnolia officinalis; 28 parts of caulis spatholobi; 12 parts of common andrographis herb; 0.002 parts of mosapride; 0.005 part of ethylplatine; 0.003 part of sodium dodecyl sulfate; 0.006 part of polyvinyl alcohol; 135 parts of milk powder; 1300 parts of water; 17500 parts of feed.
The chickens were fed 30 minutes before the epidemic prevention drug treatment, and blood was drawn 2 days later, and 89 of 10 antibody titers, 7 of diarrhea, 5 of anorexia and 5 of pecking were observed on the next day.
The following are examples, and it should be noted that the preparation methods used in examples 1, 2, and 4 are all:
step 1, preparing a first medicament and first dregs of a decoction: slicing radix Angelicae sinensis, Saviae Miltiorrhizae radix, radix Codonopsis, Atractylodis rhizoma, semen plantaginis, radix Morindae officinalis, and cortex Magnolia officinalis, cleaning, filtering, placing into a pot, adding 10 times of water, decocting with strong fire for 0.5 hr, decocting with slow fire for 1.5 hr, stopping fire, air drying to room temperature, and sieving with 100 mesh sieve to obtain first medicinal preparation and first residue.
Step 2, preparing a second medicament and second dregs of decoction: leech, aloe, caulis spatholobi and common andrographis herb are subjected to vacuum freeze drying sterilization and are placed into a pulverizer to be pulverized until the powder is sieved by a 100-mesh sieve to obtain first powder, the first powder is placed into an ultrasonic cell pulverizing extraction tank, distilled water with the weight 5 times that of the first powder is added into the ultrasonic cell pulverizing extraction tank, sodium dodecyl sulfate is added into the ultrasonic cell pulverizing extraction tank, ultrasonic treatment is carried out, the ultrasonic frequency is 3-6 times, and the ultrasonic power is 800W; taking out the materials after the ultrasonic treatment is finished, filtering to obtain a first filtrate and a first filter residue, adding distilled water with the same amount into the first filter residue, repeatedly carrying out ultrasonic treatment for 3-6 times with the ultrasonic power of 800W, taking out the materials after the ultrasonic treatment, filtering with a 200-mesh sieve to obtain a second filtrate and a second filter residue, mixing the first filtrate and the second filtrate, putting the mixture into a rotary evaporator, concentrating to obtain a second medicament, and mixing the first filter residue and the second filter residue to obtain a second medicament residue;
step 3, preparing a third medicament and third dregs of decoction: mixing and stirring the first medicament, the second medicament and polyvinyl alcohol for 20 minutes to obtain a third medicament, drying the first decoction dregs in the air, then putting the dried first decoction dregs into a crusher, crushing the first decoction dregs to a size of 100 meshes, putting the crushed first decoction dregs into a stirrer, adding the second decoction dregs, and stirring the mixture for 10 minutes to obtain third decoction dregs;
step 4, preparing a first preprocessed feed: adding the third agent, mosapride and ethylplatinum into the feed, and placing the feed into a stirrer to stir for 40 minutes to obtain a first preprocessed feed;
step 5, preparing a second preprocessed feed: adding 10 times of water into the third decoction dregs, boiling the mixture in a steamer with strong fire, and putting the first preprocessed feed in the steamer in a waterproof mode for steaming for 30 minutes to obtain a second preprocessed feed;
step 6, preparing a final feed: adding milk powder into the second preprocessed feed and stirring for 20 minutes to prepare the final feed.
Example 1:
8 parts of angelica; 10 parts of salvia miltiorrhiza; 2 parts of leech; 20 parts of codonopsis pilosula; 5 parts of bighead atractylodes rhizome; 5 parts of aloe; 25 parts of semen plantaginis; 10 parts of morinda officinalis; 9 parts of magnolia officinalis; 27 parts of caulis spatholobi; 23 parts of common andrographis herb; 0.0012 part of mosapride; 0.003 part of ethylparaben; 0.002 part of sodium dodecyl sulfate; 0.005 part of polyvinyl alcohol; 80 parts of milk powder; 900 parts of water; 1800 portions of feed.
Feeding the chickens 30 minutes before the epidemic prevention medicines are applied, blood is drawn after 2 days, 74 chickens with 10 antibody titers, 8 chickens with diarrhea, 8 chickens with anorexia the next day, and 6 chickens with peck hair.
Example 2:
15 parts of angelica; 18 parts of salvia miltiorrhiza; 4 parts of leech; 25 parts of codonopsis pilosula; 13 parts of bighead atractylodes rhizome; 12 parts of aloe; 32 parts of semen plantaginis; 16 parts of morinda officinalis; 11 parts of magnolia officinalis; 29 parts of caulis spatholobi; 28 parts of common andrographis herb; 0.0024 parts of mosapride; 0.006 part of ethylparaben; 0.004 portion of sodium dodecyl sulfate; 0.008 parts of polyvinyl alcohol; 200 parts of milk powder; 1400 parts of water; 19000 parts of feed.
The chickens were fed 30 minutes before the epidemic prevention drug treatment, and blood was drawn 2 days later, and 92 of the chickens had antibody titers of 10, 10 of the chickens had diarrhea, 4 of the chickens had anorexia the next day, and 1 of the chickens had peck hair.
The preparation method adopted in example 3 was:
step 1, preparing a first medicament and first dregs of a decoction: slicing radix Angelicae sinensis, Saviae Miltiorrhizae radix, radix Codonopsis, Atractylodis rhizoma, semen plantaginis, radix Morindae officinalis, and cortex Magnolia officinalis, cleaning, filtering, placing into a pot, adding 10 times of water, decocting with strong fire for 0.5 hr, decocting with slow fire for 1.5 hr, stopping fire, air drying to room temperature, and sieving with 100 mesh sieve to obtain first medicinal preparation and first residue.
Step 2, preparing a second medicament and second dregs of decoction: leech, aloe, caulis spatholobi and common andrographis herb are subjected to vacuum freeze drying sterilization and are placed into a pulverizer to be pulverized until the powder is sieved by a 100-mesh sieve to obtain first powder, the first powder is placed into an ultrasonic cell pulverizing extraction tank, distilled water with the weight 5 times that of the first powder is added into the ultrasonic cell pulverizing extraction tank, sodium dodecyl sulfate is added into the ultrasonic cell pulverizing extraction tank, ultrasonic treatment is carried out, the ultrasonic frequency is 3-6 times, and the ultrasonic power is 800W; taking out the materials after the ultrasonic treatment is finished, filtering to obtain a first filtrate and a first filter residue, adding distilled water with the same amount into the first filter residue, repeating the ultrasonic treatment for one time, wherein the ultrasonic frequency is 3-6 times, the ultrasonic power is 800W, taking out the materials after the ultrasonic treatment, filtering with a 200-mesh sieve to obtain a second filtrate and a second filter residue, mixing the first filtrate and the second filtrate, putting the mixture into a rotary evaporator, concentrating to obtain a second medicament, and mixing the first filter residue and the second filter residue to obtain a second medicament residue;
step 3, preparing a third medicament: mixing and stirring the first medicament, the second medicament and polyvinyl alcohol for 20 minutes to obtain a third medicament;
step 4, preparing a final feed: adding the third agent, mosapride, ethylplatinum and milk powder into the feed, and stirring in a stirrer for 40 minutes to obtain the final feed.
Example 3:
12 parts of angelica; 15 parts of salvia miltiorrhiza; 3 parts of leech; 23 parts of codonopsis pilosula; 8 parts of bighead atractylodes rhizome; 7 parts of aloe; 26 parts of semen plantaginis; 12 parts of morinda officinalis; 10 parts of magnolia officinalis; 28 parts of caulis spatholobi; 25 parts of common andrographis herb; 0.0018 part of mosapride; 0.005 part of ethylplatine; 0.003 part of sodium dodecyl sulfate; 0.006 part of polyvinyl alcohol; 135 parts of milk powder; 1300 parts of water; 17500 parts of feed.
Feeding the chickens 30 minutes before the epidemic prevention medicines are applied, blood is drawn after 2 days, 91 of 10 antibody titers are obtained, 5 of diarrhea occurs, 2 of anorexia occurs in the next day, and 1 of feather pecking occurs.
Example 4
12 parts of angelica; 15 parts of salvia miltiorrhiza; 3 parts of leech; 23 parts of codonopsis pilosula; 8 parts of bighead atractylodes rhizome; 7 parts of aloe; 26 parts of semen plantaginis; 12 parts of morinda officinalis; 10 parts of magnolia officinalis; 28 parts of caulis spatholobi; 25 parts of common andrographis herb; 0.0018 part of mosapride; 0.005 part of ethylplatine; 0.003 part of sodium dodecyl sulfate; 0.006 part of polyvinyl alcohol; 135 parts of milk powder; 1300 parts of water; 17500 parts of feed.
The chickens were fed 30 minutes before the epidemic prevention drug treatment, and blood was drawn 2 days later, and 93 of 10 antibody titers, 3 of diarrhea, 1 of anorexia and 0 of pecking were observed on the day after the feeding.
The following table was prepared based on the above experimental data:
Figure BDA0003548358600000151
referring to fig. 1, it can be seen from the above experimental data that, in comparative groups 1 and 2 and examples 1, 2, 3 and 4, when the feed is directly fed to the comparative group 1, the number of chickens with an antibody titer of 10 or more is small, and side effects are more and the effect is not good, and in the comparative group 2, the number of parts of 4 kinds of medicines, codonopsis pilosula, plantain seed, morinda officinalis and andrographis paniculata, is reduced, so that although the number of chickens with an antibody titer of 10 or more is larger than that of the comparative group 1, the effect of inhibiting the side effects is not good, while the number of chickens with an antibody titer of 10 or more in the blood of the example group is larger than that of the comparative group, the examples greatly improve the side effects such as diarrhea and trichoblast caused by vaccine, and it is worth mentioning that in example 1, the number of parts of all medicines is reduced, and the ratio of the parts of the feed is reduced most compared with the other examples, the traditional Chinese medicine has large medicinal taste, and the phenomenon that the chicken is not favorite to eat is caused, so the effect is not ideal, in example 2, the parts of all the medicines are increased, so that although the number of the chicken with the antibody titer of more than 10 is large, the side effect is increased due to the excessive medicine, and according to the component proportion and the processing mode of example 4, the side effect generated by the vaccine is remarkably reduced, the generation of the antibody can be accelerated, in example 3, the step of steaming the feed residues is reduced, and the side effect and the effective degree are not as good as those of example 4, but compared with a comparative group, the traditional Chinese medicine has large inhibition effect on the side effect under the same use condition, and simultaneously, the chicken can quickly generate the antibody.
Use case
The formula is used by aerospace culture Limited companies in high-density cities for feeding chickens 30min before oil emulsion vaccination of Newcastle disease, 100 chickens are randomly extracted for blood drawing test after vaccination for 2 days, the antibody titer reaches more than 10 and 95 chickens have diarrhea, no anorexia, pecking hair and other stress reactions, and a breeder indicates that the formula is used for feeding before vaccination, so that the chickens can generate antibodies in a short time, and compared with the method of not taking medicines and taking other medicines, the formula can greatly reduce the stress reactions.
The above-mentioned embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solution of the present invention by those skilled in the art should fall within the protection scope defined by the claims of the present invention without departing from the spirit of the present invention.

Claims (5)

1. A feed formula for promoting the effect of an epidemic prevention medicament is characterized by comprising the following materials in parts by weight: comprises 5-20 parts of angelica; 4-26 parts of salvia miltiorrhiza; 1-5 parts of leech; 15-30 parts of codonopsis pilosula; 2-15 parts of bighead atractylodes rhizome; 3-12 parts of aloe; 20-50 parts of semen plantaginis; 8-23 parts of morinda officinalis; 8-12 parts of magnolia officinalis; 25-30 parts of caulis spatholobi; 20-30 parts of common andrographis herb; 0.001-0.003 part of mosapride; 0.002-0.008 part of ethylparaben; 0.001-0.006 part of sodium dodecyl sulfate; 0.003 to 0.009 part of polyvinyl alcohol; 50-300 parts of milk powder; 800 portions of water and 1500 portions of water; 1500 + 20000 parts of feed.
2. The feed formula for promoting the effect of the epidemic prevention medicament according to claim 1, which is characterized by comprising the following materials in parts by weight: 8-15 parts of angelica; 10-18 parts of salvia miltiorrhiza; 2-4 parts of leech; 20-25 parts of codonopsis pilosula; 5-13 parts of bighead atractylodes rhizome; 5-12 parts of aloe; 25-32 parts of semen plantaginis; 10-16 parts of morinda officinalis; 9-11 parts of magnolia officinalis; 27-29 parts of caulis spatholobi; 23-28 parts of common andrographis herb; 0.0012 to 0.0024 parts of mosapride; 0.003-0.006 part of ethylparaben; 0.002-0.004 portion of sodium dodecyl sulfate; 0.005-0.008 parts of polyvinyl alcohol; 80-200 parts of milk powder; 900 portions of water and 1400 portions of water; 19000 portions of feed 1800-.
3. The feed formula for promoting the effect of the epidemic prevention medicament according to claim 2, which is characterized by comprising the following materials in parts by weight: 12 parts of angelica; 15 parts of salvia miltiorrhiza; 3 parts of leech; 23 parts of codonopsis pilosula; 8 parts of bighead atractylodes rhizome; 7 parts of aloe; 26 parts of semen plantaginis; 12 parts of morinda officinalis; 10 parts of magnolia officinalis; 28 parts of caulis spatholobi; 25 parts of common andrographis herb; 0.0018 part of mosapride; 0.005 part of ethylplatine; 0.003 part of sodium dodecyl sulfate; 0.006 part of polyvinyl alcohol; 135 parts of milk powder; 1300 parts of water; 17500 parts of feed.
4. A feed formulation for promoting the action of an epidemic prevention agent, according to any one of claims 1-3, wherein: the traditional Chinese medicine formula is prepared by the following steps:
step 1, preparing a first medicament and first dregs of a decoction: slicing radix Angelicae sinensis, Saviae Miltiorrhizae radix, radix Codonopsis, Atractylodis rhizoma, semen plantaginis, radix Morindae officinalis, and cortex Magnolia officinalis, cleaning, filtering, placing into a pot, adding 10 times of water, decocting with strong fire for 0.5 hr, decocting with slow fire for 1.5 hr, stopping fire, air drying to room temperature, and sieving with 100 mesh sieve to obtain first medicinal preparation and first residue.
Step 2, preparing a second medicament and second dregs of decoction: vacuum freeze-drying and sterilizing leeches, aloes, caulis spatholobi and andrographis paniculata, putting the leeches, aloes, caulis spatholobi and andrographis paniculata into a pulverizer, pulverizing the leeches, the aloes, the caulis spatholobi and the andrographis paniculata into a 100-mesh sieve to obtain first powder, putting the first powder into an ultrasonic cell pulverizing and extracting tank, adding distilled water which is 5 times the weight of the first powder into the ultrasonic cell pulverizing and extracting tank, adding sodium dodecyl sulfate into the ultrasonic cell pulverizing and extracting tank, and performing ultrasonic treatment for 3-6 times with the ultrasonic power of 800W; taking out the materials after the ultrasonic treatment is finished, filtering to obtain a first filtrate and a first filter residue, adding distilled water with the same amount into the first filter residue, repeatedly carrying out ultrasonic treatment for 3-6 times with the ultrasonic power of 800W, taking out the materials after the ultrasonic treatment, filtering with a 200-mesh sieve to obtain a second filtrate and a second filter residue, mixing the first filtrate and the second filtrate, putting the mixture into a rotary evaporator, concentrating to obtain a second medicament, and mixing the first filter residue and the second filter residue to obtain a second medicament residue;
step 3, preparing a third medicament and third dregs of decoction: mixing and stirring the first medicament, the second medicament and polyvinyl alcohol for 20 minutes to obtain a third medicament, drying the first decoction dregs in the air, then putting the dried first decoction dregs into a crusher, crushing the first decoction dregs until the first decoction dregs pass through a 100-mesh sieve, putting the crushed first decoction dregs into a stirrer, adding the second decoction dregs, and stirring the second decoction dregs for 10 minutes to obtain third decoction dregs;
step 4, preparing a first preprocessed feed: adding the third medicament, mosapride and ethylplatinum into the feed, and putting the feed into a stirrer to stir for 40 minutes to obtain a first preprocessed feed;
step 5, preparing a second preprocessed feed: adding 10 times of water into the third decoction dregs, boiling the mixture in a steamer with strong fire, and putting the first preprocessed feed in the steamer in a waterproof mode for steaming for 30 minutes to obtain a second preprocessed feed;
step 6, preparing a final feed: and adding milk powder into the second preprocessed feed and stirring for 20 minutes to prepare the final feed.
5. The feed formula for promoting the effect of epidemic prevention agents according to claim 4, wherein the feed formula comprises: the ultrasonic treatment mode in the step 2 is that the extraction frequency is 40kHz, the extraction time is 15 minutes, and the extraction interval is 2 minutes.
CN202210255662.8A 2022-03-15 2022-03-15 Feed formula and method for promoting epidemic prevention medicament effect Pending CN114586899A (en)

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