CN114569526A - Anti-wrinkle whitening essence and preparation method thereof - Google Patents
Anti-wrinkle whitening essence and preparation method thereof Download PDFInfo
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- CN114569526A CN114569526A CN202210201325.0A CN202210201325A CN114569526A CN 114569526 A CN114569526 A CN 114569526A CN 202210201325 A CN202210201325 A CN 202210201325A CN 114569526 A CN114569526 A CN 114569526A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 22
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 55
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 21
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- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an anti-wrinkle whitening essence and a preparation method thereof; the materials required by the anti-wrinkle whitening essence comprise the following components in percentage by mass: 5-10% of compound angelica extract, 0.1-0.5% of ginseng extract, 0.1-0.5% of coix seed extract, 0.1-0.5% of safflower extract, 1-3% of polypeptide, 1-5% of chitosan microsphere, 0.1-0.5% of honeysuckle flower leaf extract, 0.02-0.05% of citric acid, 0.4-1% of hydroxyethyl cellulose and 2-5% of 1, 2-propylene glycol, and deionized water is added to reach 100%; the compound radix Angelicae sinensis extract is mixture of radix Paeoniae alba, radix Angelicae sinensis, Aloe, and Glycyrrhrizae radix extract. The application has the advantages that the components are mainly traditional Chinese medicines, the skin allergy phenomenon can not occur when the skin cream is added, the skin cream is non-toxic and harmless, the composite wall material is added to coat the vitamin E, the effect of the vitamin E can not be influenced, and the skin cream can be placed for a long time. The essence prepared by the invention has the effects of resisting wrinkles, whitening, moisturizing, resisting oxidation and preventing sunburn, does not cause damage to skin by adopting the components, and is non-toxic and harmless.
Description
Technical Field
The invention relates to the technical field of essence preparation, and particularly relates to anti-wrinkle whitening essence and a preparation method thereof.
Background
The physical life of the modern society is more and more abundant, and women have higher and higher requirements on appearance, and generally can improve the appearance of the women through a skin care mode. In skin care products, most women have high requirements on essences, and essences with various properties are often the first choice for women.
The problem of skin aging is gradually serious along with the increase of the age of women, and wrinkles and spots are usually generated, wherein the whitening and moisturizing essence is usually purchased by women under the age of 25, and the spot-lightening and anti-wrinkle essence is selected by women over the age of 25.
The existing essences on the market have few essences and have the effects, and in order to enhance the effects, a large amount of chemical synthetic products are often selected and added, and the chemical synthetic products are used for a long time, so that the chemical synthetic products can bring side effects to the skin, such as allergic dermatitis, light anaphylactic reaction and the like, and therefore, the production of the essence capable of meeting the requirements is an urgent problem to be solved.
Disclosure of Invention
The invention aims to provide an anti-wrinkle whitening essence and a preparation method thereof, and aims to solve the problems in the background art.
In order to solve the technical problems, the invention provides the following technical scheme:
the materials required by the anti-wrinkle whitening essence comprise the following components in percentage by mass: 5-10% of compound angelica extract, 0.1-0.5% of ginseng extract, 0.1-0.5% of coix seed extract, 0.1-0.5% of safflower extract, 1-3% of polypeptide, 1-5% of chitosan microsphere, 0.1-0.5% of honeysuckle leaf extract, 0.02-0.05% of citric acid, 0.4-1% of hydroxyethyl cellulose, 2-5% of 1, 2-propylene glycol and deionized water are added to reach 100%.
In a further optimized scheme, the compound angelica extract is a mixture of extracts of white paeony root, angelica, aloe and liquorice.
According to a further optimized scheme, the preparation method of the anti-wrinkle whitening essence comprises the following steps:
s1: extracting radix Paeoniae alba with 80% ethanol under microwave for 5-10 min; extracting radix Angelicae sinensis and Glycyrrhrizae radix with deionized water by microwave for 5-10min, cleaning folium Aloe, chopping, grinding, soaking in ether solution for 4-6 hr, vacuum filtering, adding anhydrous ethanol, soaking for 22-25 hr, distilling under reduced pressure, adsorbing to remove bitter components, concentrating, and mixing with extracted radix Paeoniae alba, radix Angelicae sinensis and Glycyrrhrizae radix to obtain compound radix Angelicae sinensis extract;
s2: sieving the honeysuckle leaves with a sieve of 200-plus 800 meshes, adding absolute ethyl alcohol, carrying out water bath reaction, carrying out suction filtration, and retaining the solution to obtain the honeysuckle leaf extract;
s3: dissolving sodium alginate in deionized water, adding vitamin E and nano calcium carbonate, mixing uniformly, performing ultrasonic reaction for 0.5-2h, adding a mixture of liquid paraffin and tween 80, mixing uniformly, slowly adding a mixed solution of glacial acetic acid and liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding an aqueous solution of modified chitosan, mixing uniformly, reacting for 30-60min, washing, centrifuging, freeze-drying, dissolving in deionized water, adding organic montmorillonite and titanium dioxide, performing microwave radiation reaction for 2h, dialyzing, and freeze-drying to obtain chitosan microspheres;
s4: uniformly mixing 1, 2-propylene glycol, citric acid, a ginseng extract, a coix seed extract, a safflower extract, chitosan microspheres, a honeysuckle leaf extract and deionized water, adding hydroxyethyl cellulose, heating to 60-80 ℃, reacting for 1-2 hours, cooling to room temperature, adding a compound Chinese angelica extract and polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
In a further optimized scheme, in the step S2, the content of the absolute ethyl alcohol is 60%, the mass ratio of the honeysuckle leaves to the absolute ethyl alcohol is 1:12, the reaction temperature is 60-70 ℃, and the reaction time is 4-5 hours.
In a further optimized scheme, in step S3, the preparation method of the modified chitosan comprises: dissolving chitosan in acetic acid solution, adding succinic anhydride, mixing uniformly, adjusting the pH value of the solution to 7-8, reacting for 6-8h, adding absolute ethyl alcohol, filtering, extracting for 20-25h, and drying to obtain the modified chitosan.
In a further optimized scheme, in step S1, the microwave extraction power of the white paeony root is 400W; the microwave extraction power of the angelica and the liquorice is 800W.
In a further optimized scheme, the microwave radiation power is 800W, and the radiation temperature is 85 ℃.
The honeysuckle flower leaf extract is prepared by taking the alcohol extract of honeysuckle leaves as the honeysuckle leaf extract, has the advantages of no toxicity, no harm, no allergy, no stimulation and other reactions, can avoid the safety problem existing in the synthesis of the honeysuckle leaf extract, contains a large amount of flavonoids substances in the honeysuckle leaves, has the effects of oxidation resistance, antibiosis, antiphlogosis and the like, and can avoid the influence on the antibiosis due to the fact that the extract contains starch or inorganic salt and other impurities when deionized water is used as the extract. In addition, the application limits that the content of the absolute ethyl alcohol is 60%, the mass ratio of the honeysuckle leaves to the absolute ethyl alcohol is 1:12, the reaction temperature is 60-70 ℃, the reaction time is 4-5h, the extraction amount of flavonoid substances can be increased, and the antibacterial activity of essence is improved. The flavonoids have strong antioxidant effect, and can be used for essence to consume free radicals generated by long-term storage of essence, and prolong whitening and anti-wrinkle effects of essence.
The extracts of the white paeony root, the angelica, the aloe and the liquorice are compounded to prepare a compound angelica extract which is added into the essence to endow the essence with the effects of whitening and lightening spots. Radix Paeoniae alba has antiinflammatory effect, and can be used for treating facial acne and comedo, radix Angelicae sinensis contains abundant amino acids and inorganic salts, and can promote skin metabolism and keep skin clean, Aloe contains abundant vitamins and amino acids, and has speckle reducing, antiinflammatory and skin nourishing effects, and Glycyrrhrizae radix can remove melanin, and has whitening and moisturizing effects. The extract of ginseng, coix seed and safflower is added into the application as a natural humectant, and when the extract is used, the extract can increase the moisture of the horny layer and repair the barrier. The polypeptide has anti-wrinkle effect.
The chitosan reacts with succinic anhydride, and the succinyl chitosan is generated by the reaction of amino and carboxyl, so that the solubility of the chitosan is improved, and then the chitosan reacts with titanium dioxide, and the titanium dioxide can be fixed on the surface of the chitosan and is not easy to fall off, so that the chitosan can absorb ultraviolet rays under various wave bands, and the sun-screening performance of the essence is improved.
The vitamin E is coated by the sodium alginate, the vitamin E has the effects of oxidation resistance and skin aging delaying, but the vitamin E leads oil-soluble substances to be insoluble in water and easily damaged by ultraviolet rays and lose the performance of the vitamin E, therefore, the vitamin E is coated by the sodium alginate at first, the solubility of the microbial E is improved, the microbial E is prevented from being damaged by the ultraviolet rays, the slow release effect is achieved, in order to prevent the vitamin E from being leaked when the sodium alginate is separately coated by the vitamin E, the composite wall material is prepared by compounding the modified chitosan and the sodium alginate, the vitamin E is coated at the same time, the coating rate of the vitamin E is improved by utilizing the excellent solubility and biocompatibility of the modified chitosan, the leakage of the vitamin E is avoided, and the modified chitosan and the sodium alginate can be crosslinked with calcium carbonate to form a network structure, the chitosan can fill up micropores on the surface of the sodium alginate microspheres and reinforce the wall material. When the composite wall material is coated outside the vitamin E, the effect of the vitamin E cannot be influenced because of physical coating, so that the composite microspheres can still have the effects of oxidation resistance, whitening and sun protection. Finally, the composite microspheres are intercalated between the montmorillonite layers, and the montmorillonite is added into the essence by utilizing the adsorbability of the montmorillonite, so that facial grease and toxin can be adsorbed when the montmorillonite is used, and meanwhile, the moisture retention of the essence can be improved by the montmorillonite.
Compared with the prior art, the invention has the following beneficial effects: the essence prepared by the invention has the effects of resisting wrinkles, whitening, moisturizing, resisting oxidation and preventing sunburn, does not cause damage to skin by adopting the components, and is non-toxic and harmless.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1: a preparation method of anti-wrinkle whitening essence comprises the following steps:
s1: setting the microwave extraction power at 400W, and performing microwave extraction on 10 parts of white paeony root by using 60 parts of 80% ethanol for 5 min; setting the microwave extraction power to 800W, performing microwave extraction on 10 parts of Chinese angelica and 10 parts of liquorice for 5min respectively by using 120 parts of deionized water, cleaning, chopping and grinding aloe leaves, soaking the aloe leaves in 100 parts of ether solution for 4h, performing suction filtration, adding 300 parts of 95% absolute ethyl alcohol, continuing to soak for 22h, performing reduced pressure distillation to remove bitter components by adsorption, and uniformly mixing the concentrated solution with the extracted white paeony root, Chinese angelica and liquorice after low-temperature concentration to obtain a compound Chinese angelica extract; the mass ratio of the extracted aloe to the white paeony root, the Chinese angelica and the liquorice is 1:1:1: 1;
s2: soaking Ginseng radix in 70% anhydrous ethanol solution for 0.5 hr, reflux reacting for 2 hr, filtering, and concentrating the filtrate to obtain Ginseng radix extractive solution; soaking Carthami flos in deionized water, performing ultrasonic reaction for 0.5h, filtering, retaining residue, adding deionized water, continuing ultrasonic reaction for 0.5h, filtering to obtain mobile phone filtrate as Carthami flos extract; soaking semen Persicae in deionized water, boiling, reacting for 0.5 hr, and filtering to obtain semen Persicae extract;
s3: sieving honeysuckle leaves with a 800-mesh sieve, adding 60% absolute ethyl alcohol, carrying out suction filtration after reacting in a water bath at 60 ℃ for 4h, and reserving a solution to obtain a honeysuckle leaf extract; the mass ratio of the honeysuckle leaves to the absolute ethyl alcohol is 1: 12;
s4: dissolving 1 part of chitosan in 50 parts of 1% acetic acid solution, reacting for 1 hour, adding 2 parts of succinic anhydride, mixing uniformly, adjusting the pH value of the solution to 7, reacting for 6 hours, adding 100 parts of absolute ethyl alcohol, filtering, extracting for 20 hours, and drying to obtain modified chitosan;
s5: dissolving 15 parts of sodium alginate in 20 parts of deionized water, adding 7 parts of vitamin E and 5 parts of nano calcium carbonate, uniformly mixing, carrying out ultrasonic reaction for 0.5h, adding a mixture of 5 parts of liquid paraffin and 3 parts of Tween 80, uniformly mixing, slowly adding a mixed solution of 10 parts of glacial acetic acid and liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding 100 parts of an aqueous solution of modified chitosan, uniformly mixing, reacting for 30min, washing with deionized water, centrifuging, freeze-drying, adding 150 parts of deionized water, 10 parts of 0.1% swelled organic montmorillonite and 0.2 part of titanium dioxide, carrying out microwave radiation reaction for 2h at 85 ℃ under the power of 800W, dialyzing, and carrying out freeze-drying at-50 ℃ to obtain chitosan microspheres;
s6: uniformly mixing 2% of 1, 2-propylene glycol, 0.02% of citric acid, 0.1% of ginseng extract, 0.1% of coix seed extract, 0.1% of safflower extract, 1% of chitosan microspheres, 0.1% of honeysuckle leaf extract and 90.18% of deionized water, adding 0.4% of hydroxyethyl cellulose, heating to 60 ℃, reacting for 1 hour, cooling to room temperature, adding 5% of compound Chinese angelica extract and 1% of polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
Example 2: a preparation method of anti-wrinkle whitening essence comprises the following steps:
s1: setting the microwave extraction power at 400W, and performing microwave extraction on 11 parts of white paeony root for 6min by using 70 parts of 80% ethanol; setting the microwave extraction power at 800W, performing microwave extraction on 10 parts of Chinese angelica and 10 parts of liquorice for 6min respectively by using 120 parts of deionized water, cleaning, chopping and grinding aloe leaves, soaking the aloe leaves in 105 parts of ether solution for 4.5h, performing suction filtration, adding 350 parts of 95% absolute ethyl alcohol, continuing to soak for 23h, performing reduced pressure distillation, adsorbing and removing bitter components, and uniformly mixing the concentrated aloe leaves with the extracted white paeony root, Chinese angelica and liquorice after low-temperature concentration to obtain a compound Chinese angelica extract; the mass ratio of the extracted aloe to the white paeony root, the Chinese angelica and the liquorice is 1:1:1: 1;
s2: soaking Ginseng radix in 70% anhydrous ethanol solution for 0.5 hr, reflux reacting for 2 hr, filtering, and concentrating the filtrate to obtain Ginseng radix extractive solution; soaking Carthami flos in deionized water, performing ultrasonic reaction for 0.5h, filtering, retaining residue, adding deionized water, continuing ultrasonic reaction for 0.5h, filtering, and collecting filtrate to obtain Carthami flos extract; soaking semen Persicae in deionized water, boiling, reacting for 0.5 hr, and filtering to obtain semen Persicae extract;
s3: sieving folium Lonicerae with 800 mesh sieve, adding 60% anhydrous ethanol, performing water bath reaction at 62 deg.C for 4.2h, and vacuum filtering to obtain retained solution, i.e. folium Lonicerae extract; the mass ratio of the honeysuckle leaves to the absolute ethyl alcohol is 1: 12;
s4: dissolving 2 parts of chitosan in 55 parts of 1% acetic acid solution, reacting for 1.5h, adding 3 parts of succinic anhydride, mixing uniformly, adjusting the pH value of the solution to 7.2, reacting for 6.5h, adding 110 parts of absolute ethyl alcohol, filtering, extracting for 21h, and drying to obtain modified chitosan;
s5: dissolving 16 parts of sodium alginate in 22 parts of deionized water, adding 8 parts of vitamin E and 6 parts of nano calcium carbonate, uniformly mixing, after carrying out ultrasonic reaction for 1h, adding a mixture of 6 parts of liquid paraffin and 3.5 parts of Tween 80, after uniformly mixing, slowly adding a mixed solution of 11 parts of glacial acetic acid and the liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding 110 parts of an aqueous solution of modified chitosan, uniformly mixing, reacting for 40min, washing with deionized water, centrifuging, freeze-drying, adding 160 parts of deionized water, 11 parts of 0.1% swelled organic montmorillonite and 0.3 part of titanium dioxide, carrying out microwave radiation reaction for 2h at 85 ℃ under the power of 800W, dialyzing, and freeze-drying at-50 ℃ to obtain chitosan microspheres;
s6: uniformly mixing 3% of 1, 2-propylene glycol, 0.03% of citric acid, 0.2% of ginseng extract, 0.1% of coix seed extract, 0.2% of safflower extract, 2% of chitosan microspheres, 0.2% of honeysuckle leaf extract and 85.78% of deionized water, adding 0.5% of hydroxyethyl cellulose, heating to 70 ℃, reacting for 1.5h, cooling to room temperature, adding 6% of compound angelica extract and 2% of polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
Example 3: a preparation method of anti-wrinkle whitening essence comprises the following steps:
s1: setting the microwave extraction power at 400W, and performing microwave extraction on 15 parts of white paeony root for 5-10min by using 80 parts of 80% ethanol; setting the microwave extraction power to 800W, performing microwave extraction on 11 parts of Chinese angelica and 11 parts of liquorice for 8min respectively by using 200 parts of deionized water, cleaning, chopping and grinding aloe leaves, soaking the aloe leaves in 115 parts of ether solution for 5.5h, performing suction filtration, adding 400 parts of 95% absolute ethyl alcohol, continuing to soak for 24h, performing reduced pressure distillation, adsorbing and removing bitter components, and uniformly mixing the concentrated aloe leaves with the extracted white paeony root, Chinese angelica and liquorice after low-temperature concentration to obtain a compound Chinese angelica extract; the mass ratio of the extracted aloe to the white paeony root, the Chinese angelica and the liquorice is 1:1:1: 1;
s2: soaking Ginseng radix in 70% anhydrous ethanol solution for 0.5 hr, reflux reacting for 2 hr, filtering, and concentrating the filtrate to obtain Ginseng radix extractive solution; soaking Carthami flos in deionized water, performing ultrasonic reaction for 0.5h, filtering, retaining residue, adding deionized water, continuing ultrasonic reaction for 0.5h, filtering, and collecting filtrate to obtain Carthami flos extract; soaking semen Persicae in deionized water, boiling, reacting for 0.5 hr, and filtering to obtain semen Persicae extract;
s3: sieving folium Lonicerae with 500 mesh sieve, adding 60% anhydrous ethanol, reacting in 65 deg.C water bath for 4.8 hr, vacuum filtering, and retaining solution to obtain folium Lonicerae extract; the mass ratio of the honeysuckle leaves to the absolute ethyl alcohol is 1: 12;
s4: dissolving 4 parts of chitosan in 75 parts of 1% acetic acid solution, reacting for 2.5h, adding 5 parts of succinic anhydride, mixing uniformly, adjusting the pH value of the solution to 7.5, reacting for 7.5h, adding 150 parts of absolute ethyl alcohol, filtering, extracting for 24h, and drying to obtain modified chitosan;
s5: dissolving 18 parts of sodium alginate in 28 parts of deionized water, adding 8 parts of vitamin E and 11 parts of nano calcium carbonate, uniformly mixing, carrying out ultrasonic reaction for 1.5h, adding a mixture of 7 parts of liquid paraffin and 4.5 parts of Tween 80, uniformly mixing, slowly adding a mixed solution of 16 parts of glacial acetic acid and liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding 130 parts of a modified chitosan aqueous solution, uniformly mixing, reacting for 50min, washing with deionized water, centrifuging, freeze-drying, adding 170 parts of deionized water, 18 parts of 0.1% swelled organic montmorillonite and 0.4 part of titanium dioxide, carrying out microwave radiation reaction for 2h at the temperature of 85 ℃, dialyzing, and carrying out freeze-drying at-50 ℃ to obtain chitosan microspheres;
s5: uniformly mixing 4% of 1, 2-propylene glycol, 0.04% of citric acid, 0.2% of ginseng extract, 0.2% of coix seed extract, 0.2% of safflower extract, 4% of chitosan microspheres, 0.4% of honeysuckle leaf extract and 80.36% of deionized water, adding 0.6% of hydroxyethyl cellulose, heating to 75 ℃, reacting for 1.6h, cooling to room temperature, adding 8% of compound angelica extract and 2% of polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
Example 4: a preparation method of anti-wrinkle whitening essence comprises the following steps:
s1: setting the microwave extraction power to 400W, and performing microwave extraction on 20 parts of white paeony root for 10min by using 120 parts of 80% ethanol; setting the microwave extraction power to 800W, performing microwave extraction on 12 parts of Chinese angelica and 12 parts of liquorice for 10min respectively by using 240 parts of deionized water, cleaning, chopping and grinding aloe leaves, soaking the aloe leaves in 120 parts of ether solution for 6h, performing suction filtration, adding 500 parts of 95% absolute ethyl alcohol, continuing to soak for 25h, performing reduced pressure distillation to remove bitter components by adsorption, and uniformly mixing the concentrated solution with the extracted white paeony root, Chinese angelica and liquorice after low-temperature concentration to obtain a compound Chinese angelica extract; the mass ratio of the extracted aloe to the white paeony root, the Chinese angelica and the liquorice is 1:1:1: 1;
s2: soaking Ginseng radix in 70% anhydrous ethanol solution for 0.5 hr, reflux reacting for 2 hr, filtering, and concentrating the filtrate to obtain Ginseng radix extractive solution; soaking Carthami flos in deionized water, performing ultrasonic reaction for 0.5h, filtering, retaining residue, adding deionized water, continuing ultrasonic reaction for 0.5h, filtering, and collecting filtrate to obtain Carthami flos extract; soaking semen Persicae in deionized water, boiling, reacting for 0.5 hr, and filtering to obtain semen Persicae extract;
s3: sieving folium Lonicerae with-800 mesh sieve, adding 60% anhydrous ethanol, performing water bath reaction at 70 deg.C for 5 hr, and vacuum filtering to obtain folium Lonicerae extract; the mass ratio of the honeysuckle leaves to the absolute ethyl alcohol is 1: 12;
s4: dissolving 5 parts of chitosan in 80 parts of 1% acetic acid solution, reacting for 3 hours, adding 10 parts of succinic anhydride, mixing uniformly, adjusting the pH value of the solution to 8, reacting for 8 hours, adding 200 parts of absolute ethyl alcohol, filtering, extracting for 25 hours, and drying to obtain modified chitosan;
s5: dissolving 20 parts of sodium alginate in 30 parts of deionized water, adding 10 parts of vitamin E and 12 parts of nano calcium carbonate, uniformly mixing, after carrying out ultrasonic reaction for 2 hours, adding a mixture of 8 parts of liquid paraffin and 5 parts of Tween 80, after uniformly mixing, slowly adding a mixed solution of 20 parts of glacial acetic acid and the liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding 150 parts of an aqueous solution of modified chitosan, uniformly mixing, reacting for 60 minutes, washing with deionized water, centrifuging, freeze-drying, adding 180 parts of deionized water, 20 parts of 0.1% swelled organic montmorillonite and 0.6 part of titanium dioxide, carrying out microwave radiation reaction for 2 hours at 85 ℃ under the power of 800W, dialyzing, and freeze-drying at-50 ℃ to obtain chitosan microspheres;
s6: uniformly mixing 5% of 1, 2-propylene glycol, 0.05% of citric acid, 0.3% of ginseng extract, 0.3% of coix seed extract, 0.1% of safflower extract, 5% of chitosan microspheres, 0.5% of honeysuckle leaf extract and 74.75% of deionized water, adding 1% of hydroxyethyl cellulose, heating to 80 ℃, reacting for 2 hours, cooling to room temperature, adding 10% of compound angelica extract and 3% of polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
Comparative example
Comparative example 1: in contrast to example 1, vitamin E was coated with sodium alginate only and prepared in the same manner as in example 1.
Comparative example 2: in comparison with example 1, no modification of chitosan was performed, and no titanium dioxide was added, and the preparation method was the same as example 1.
Experimental data
Experiment 1:
hydroxyl radical scavenging rate: 0.5mL of o-diazaphenanthrene ethanol solution, 1.0mL of PBS with the pH value of 7.4, 0.5mL of deionized water, 0.5mL of ferric sulfate and 0.5mL of hydrogen peroxide are uniformly mixed, reacted for 1h in a water bath kettle at 37 ℃, and the absorbance at 536nm is measured and is marked as A1Repeating the operation, replacing the hydrogen peroxide with deionized water, measuring the absorbance at 536nm, and recording the absorbance as A2Calculating the clearance, repeating the operation, replacing the deionized water with the sample, and recording the absorbance as A3。
The samples were left to stand for 6 months and tested once more.
Superoxide anion radical scavenging: adding 2.8mL of Tris-HCl buffer solution into the sample, reacting at 25 deg.C for 0.5h, adding 0.1mL of pyrogallol at 25 deg.C, measuring absorbance at intervals of 30s at 320nm for 5min, and plotting, wherein the slope is A1Repeating the operation, replacing the sample with 0.1mL of Tris-HCl buffer solution, and recording the slope as A2. The samples were left to stand for 6 months and tested once more.
Table 1 radical scavenging rates for examples 1-4, comparative examples 1-2
Experiment 2:
selecting 80 volunteers of 25-55 years old, randomly grouping, 5 volunteers in each group, washing face in the morning and evening each day, smearing essence, continuously using for 1 month, using melanin tester, and calculating skin melanin content before and after using essence according to average value.
Table 2 melanin assays of examples 1-4, comparative examples 1-2
| Melanin value before use | Melanin value after use | Difference value | |
| Example 1 | 156 | 95 | 58 |
| Example 2 | 197 | 135 | 62 |
| Example 3 | 162 | 97 | 65 |
| Example 4 | 209 | 154 | 55 |
| Comparative example 1 | 173 | 125 | 48 |
| Comparative example 2 | 198 | 172 | 26 |
Experiment 3: selecting 80 volunteers of 25-55 years old, randomly grouping, 5 volunteers in each group, washing face in the morning and evening each day, smearing essence, continuously using for 1 month, performing skin feel evaluation, and grading speckle fading and wrinkle resisting effects; and 5, dividing: the effect is obvious; and 4, dividing: the effect is good; and 3, dividing: the effect is general; and 2, dividing: the effect is not obvious.
Table 3 skin feel evaluation of examples 1 to 4 and comparative examples 1 to 2
| Speckle reduction | Anti-wrinkle | Skin feel evaluation | |
| Example 1 | 5 | 4 | Good moisture-keeping effect and no allergy |
| Example 2 | 5 | 4 | Good moisture-keeping effect and no allergy |
| Example 3 | 5 | 5 | Good moisture-keeping effect and no allergy |
| Example 4 | 4 | 4 | Good moisture-keeping effect and no allergy |
| Comparative example 1 | 4 | 4 | Good moisture-keeping effect and no allergy |
| Comparative example 2 | 4 | 4 | Good moisture-keeping effect and no allergy |
And (4) conclusion:
1. the essence prepared by the application has the effects of spot lightening, wrinkle resistance, whitening and oxidation resistance, does not contain irritant substances, can be used by people of any skin type and any age, and does not generate an allergy phenomenon.
2. Compared with the comparative example 1, the comparative example 1 only uses sodium alginate to coat the vitamin E, so that the effect of the essence on the clearance rate of free radicals is better in the early stage, and when the essence is placed for a long time, the clearance rate of the free radicals is reduced, which shows that the condition of leakage can occur when the sodium alginate is used alone to coat the vitamin E, so that the anti-oxygen property is reduced.
3. Compared with the comparative example 2, the comparative example 2 does not modify chitosan and does not add titanium dioxide, so that the free radical clearance is reduced slightly in the later period, and the reduction value of melanin is smaller after the chitosan is modified and the titanium dioxide is added, so that ultraviolet rays can be absorbed, and the increase of melanin is avoided. The chitosan is modified, so that the solubility of the chitosan in an aqueous solution can be improved, the coating rate of the chitosan microspheres is improved, and the vitamin E is prevented from flowing out.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (7)
1. An anti-wrinkle whitening essence is characterized in that: the materials required by the anti-wrinkle whitening essence comprise the following components in percentage by mass: 5-10% of compound angelica extract, 0.1-0.5% of ginseng extract, 0.1-0.5% of coix seed extract, 0.1-0.5% of safflower extract, 1-3% of polypeptide, 1-5% of chitosan microsphere, 0.1-0.5% of honeysuckle leaf extract, 0.02-0.05% of citric acid, 0.4-1% of hydroxyethyl cellulose, 2-5% of 1, 2-propylene glycol and deionized water are added to reach 100%.
2. The anti-wrinkle whitening essence according to claim 1, characterized in that: the compound radix Angelicae sinensis extract is mixture of radix Paeoniae alba, radix Angelicae sinensis, Aloe, and Glycyrrhrizae radix extract.
3. A preparation method of anti-wrinkle whitening essence is characterized by comprising the following steps: the method comprises the following steps:
s1: extracting radix Paeoniae alba with 80% ethanol under microwave for 5-10 min; extracting radix Angelicae sinensis and Glycyrrhrizae radix with deionized water by microwave for 5-10min, cleaning folium Aloe, chopping, grinding, soaking in ether solution for 4-6 hr, vacuum filtering, adding anhydrous ethanol, soaking for 22-25 hr, distilling under reduced pressure, adsorbing to remove bitter components, concentrating, and mixing with extracted radix Paeoniae alba, radix Angelicae sinensis and Glycyrrhrizae radix to obtain compound radix Angelicae sinensis extract;
s2: sieving the honeysuckle leaves with a sieve of 200-800 meshes, adding absolute ethyl alcohol, carrying out water bath reaction, carrying out suction filtration, and reserving a solution to obtain a honeysuckle leaf extract;
s3: dissolving sodium alginate in deionized water, adding vitamin E and nano calcium carbonate, mixing uniformly, performing ultrasonic reaction for 0.5-2h, adding a mixture of liquid paraffin and tween 80, mixing uniformly, slowly adding a mixed solution of glacial acetic acid and liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding an aqueous solution of modified chitosan, mixing uniformly, reacting for 30-60min, washing, centrifuging, freeze-drying, dissolving in deionized water, adding organic montmorillonite and titanium dioxide, performing microwave radiation reaction for 2h, dialyzing, and freeze-drying to obtain chitosan microspheres;
s4: uniformly mixing 1, 2-propylene glycol, citric acid, a ginseng extract, a coix seed extract, a safflower extract, chitosan microspheres, a honeysuckle leaf extract and deionized water, adding hydroxyethyl cellulose, heating to 60-80 ℃, reacting for 1-2h, cooling to room temperature, adding a compound Chinese angelica extract and polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
4. The preparation method of the anti-wrinkle whitening essence according to claim 3, characterized in that: in step S2, the content of absolute ethyl alcohol is 60%, the mass ratio of honeysuckle leaves to absolute ethyl alcohol is 1:12, the reaction temperature is 60-70 ℃, and the reaction time is 4-5 h.
5. The preparation method of the anti-wrinkle whitening essence according to claim 3, wherein the preparation method comprises the following steps: in step S3, the preparation method of the modified chitosan comprises: dissolving chitosan in acetic acid solution, adding succinic anhydride, mixing uniformly, adjusting the pH value of the solution to 7-8, reacting for 6-8h, adding absolute ethyl alcohol, filtering, extracting for 20-25h, and drying to obtain the modified chitosan.
6. The preparation method of the anti-wrinkle whitening essence according to claim 3, wherein the preparation method comprises the following steps: in step S1, the microwave extraction power of the white paeony root is 400W; the microwave extraction power of the angelica and the liquorice is 800W.
7. The preparation method of the anti-wrinkle whitening essence according to claim 3, wherein the preparation method comprises the following steps: the microwave radiation power is 800W, and the radiation temperature is 85 ℃.
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| CN117598957A (en) * | 2024-01-16 | 2024-02-27 | 广州市百益康生物科技发展有限公司 | Tea polyphenol extract and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115869225A (en) * | 2022-10-26 | 2023-03-31 | 现代百朗德生物科技(江苏)有限公司 | Peach-red four-ingredient soup cosmetic composition with whitening, antioxidant and anti-wrinkle effects and application of peach-red four-ingredient soup cosmetic composition in cosmetics |
| CN117598957A (en) * | 2024-01-16 | 2024-02-27 | 广州市百益康生物科技发展有限公司 | Tea polyphenol extract and preparation method thereof |
| CN117598957B (en) * | 2024-01-16 | 2024-05-07 | 广州市百益康生物科技发展有限公司 | Tea polyphenol extract and preparation method thereof |
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| CN114569526B (en) | 2023-12-05 |
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