CN106265391A - A kind of sun-proof moisturizer and preparation method and application - Google Patents

A kind of sun-proof moisturizer and preparation method and application Download PDF

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CN106265391A
CN106265391A CN201610962258.9A CN201610962258A CN106265391A CN 106265391 A CN106265391 A CN 106265391A CN 201610962258 A CN201610962258 A CN 201610962258A CN 106265391 A CN106265391 A CN 106265391A
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proof
sun
moisturizer
chitosan
titanium oxide
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王少琼
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/025—Explicitly spheroidal or spherical shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Abstract

The invention belongs to cosmetic field, be specifically related to a kind of sun-proof moisturizer and preparation method and application.Described sun-proof moisturizer, comprises component nano titanium oxide carboxymethyl chitosan complex microsphere, Flos persicae extract, Flos Lonicerae extract, Cyclomethicone, isononyl isononanoate, glycerol, pantothenylol, nicotiamide, spermol, xanthan gum, methyl sesquistearate, glyceryl stearate, essence and water.The effects such as the anti-sunlight function of nano titanium oxide, moisture absorption that chitosan is good, moisturizing, skin moistening are combined by the present invention, not only overcome the tradition problems such as sunscreen nano titanium oxide is easily reunited, consumption is big, and both combinations have good Synergistic antimicrobial and antiseptic effect and stability and persistency to sun-proof moisturizer have higher enhancement effect.Additionally, the present invention also comprises component Flos persicae extract and Flos Lonicerae extract, and other component scientific matchings, can all band high-selenium corn ultraviolet.

Description

A kind of sun-proof moisturizer and preparation method and application
Technical field
The invention belongs to cosmetic field, be specifically related to a kind of sun-proof moisturizer and preparation method and application.
Background technology
Ultraviolet is a kind of light wave bigger to harm in sunlight.Excessive radiation ultraviolet, can make skin produce Erythema, black speck, make skin aging, serious meeting cause skin carcinoma.In recent years, the raising along with people, ultraviolet recognized and guarantor The enhancing of strong consciousness, the exploitation of sun-proof type cosmetics, application are increasingly becoming a scientific research focus.
Titanium dioxide is owing to having high refractivity and high photolytic activity, always by as a kind of main sunscreen.Nanometer two Titanium oxide is extensively paid attention to because there being the most superior performance, is used for novel, the research and development of high-quality sun care preparations, Progressively show its special superiority and wide application prospect.But titanium dioxide sunscreen agent has, and consumption is big, sun-proof result is poor Etc. shortcoming, excessive use easily blocks pore, affects the secretion of sebaceous gland and sweat gland, the adverse consequences such as new disease causing skin.
Chitosan as a kind of aboundresources, cheap natural polymer, has good moisture absorption, guarantor The effects such as wet, hair care, skin moistening, have caused the extensive concern of cosmetics circle.Chitosan is when make-up and beauty, it is easy to is formed and protects Ski protective film, its moisture absorption, water retention, can make that skin becomes soft, moistening, ductility is good.Although chitosan can be applicable to make up In product, but because it is water insoluble, can only be dissolved in acid so that product is subacidity, to skin slightly stimulation, thus to shell Polysaccharide is modified preparing water-solubility chitosan derivative and seems and be highly desirable to.In recent years, grinding in terms of modification of chitosan Study carefully more and more, and be used for multiple chitosan derivatives preparing clean skin and skin care liquid, protective skin cream, emulsion, hair conditioning shampoo, face Film etc..
How titanium dioxide and chitosan are carried out reasonable modification, and combines both advantages and prepare novel, effective, safe Sunscreen is current yet unresolved issue.
Summary of the invention
In order to overcome the deficiencies in the prior art and shortcoming, the primary and foremost purpose of the present invention is to provide a kind of sun-proof moisturizer.
Another object of the present invention is to provide the preparation method of above-mentioned sun-proof moisturizer.
It is still another object of the present invention to provide the application of above-mentioned sun-proof moisturizer.
The purpose of the present invention is achieved through the following technical solutions:
A kind of sun-proof moisturizer, comprises following component the most in parts by mass:
Described sun-proof moisturizer, preferably comprises following component the most in parts by mass:
The preparation method of described nano titanium oxide-carboxymethyl chitosan complex microsphere, comprises the steps of:
(1) chitosan is mixed with dehydrated alcohol, supersound process 10～20min, be subsequently adding sodium hydroxide solution, 0 ～basification 4～5h under the conditions of 10 DEG C；Being then slowly added into monoxone, under the conditions of 60～70 DEG C, stirring reaction 3～6h, obtains Carboxymethyl chitosan；
(2) carboxymethyl chitosan that step (1) prepares is dissolved in water, obtains carboxymethyl chitosan solution, by nano-silica Change titanium to be dispersed in carboxymethyl chitosan solution, be then added dropwise in the liquid paraffin containing surfactant, 40 ～45 DEG C of stir process, form w/o type emulsion；Add chemical cross-linking agent genipin, crosslinking curing under conditions of 40～50 DEG C Reaction 3～4h, centrifugal, washing, obtain nano titanium oxide-carboxymethyl chitosan complex microsphere；
The viscosity-average molecular weight of the chitosan described in step (1) is preferably 0.8 × 104～16 × 104；
Chitosan described in step (1) is preferably 1:(25～50 with the mass volume ratio (g:ml) of dehydrated alcohol)；
The mass fraction of the sodium hydroxide solution described in step (1) is preferably 40～45%；
Chitosan described in step (1) is preferably 1:(4～6 with the mass ratio of sodium hydroxide in sodium hydroxide solution)；
Chitosan described in step (1) and chloroacetic mass ratio are preferably 1:(3～5)；
The substitution value of the carboxymethyl chitosan described in step (1) is preferably not less than 1；
The mass fraction of the carboxymethyl chitosan solution described in step (2) is preferably 10～20%；
The particle diameter of the nano titanium oxide described in step (2) is preferably 40～80nm；
Surfactant described in step (2) is preferably span-80；
Consumption is liquid paraffin quality 1～2% of surfactant described in step (2)；
Consumption is carboxymethyl chitosan quality 35～40% of chemical cross-linking agent genipin described in step (2)；
Carboxymethyl chitosan solution described in step (2) is preferably 1:(8～10 with the mass ratio of liquid paraffin)；
Nano titanium oxide and carboxymethyl in nano titanium oxide described in step (2)-modification of chitosan complex microsphere The mass ratio of chitosan is preferably (8～10): 1；
The preparation method of described sun-proof moisturizer, comprises the steps of:
(1) by Cyclomethicone, isononyl isononanoate, spermol, methyl sesquistearate and glycerol Stearate mixes, and at 60～80 DEG C, heated and stirred mixing, obtains product 1；
(2) glycerol, pantothenylol, nicotiamide, xanthan gum, essence and water are mixed, heated and stirred mixing at 60～80 DEG C, To product 2；
(3) under agitation, the product 2 that the product 1 step (1) prepared prepares with step (2) mixes, and vacuum is equal Matter emulsifying, obtains product 3；
(4) after prepared for step (3) product being cooled to 30～40 DEG C, with remaining component (nano-silica of sun-proof moisturizer Change titanium-modification of chitosan complex microsphere, Flos persicae extract and Flos Lonicerae extract) mix homogeneously, obtain sun-proof moisturizer；
Heated and stirred described in step (1) is preferably carried out in oil phase pot；
The condition of the heated and stirred described in step (1) is preferably heated and stirred 30～60min at 60～80 DEG C；
Heated and stirred described in step (2) is preferably carried out in aqueous phase pot；
The condition of the heated and stirred described in step (2) is preferably heated and stirred 30～40min at 60～80 DEG C；
The time of the vacuum emulsifying described in step (3) is preferably 10～15min；
The principle of the present invention:
The present invention selects the chitosan of suitable viscosity-average molecular weight, by optimizing sodium hydroxide concentration, monoxone consumption, reaction The parameter such as time and reaction temperature, it is thus achieved that high substituted degree, the carboxymethyl chitosan of humectant, and by emulsion-crosslinking method, system While standby Crosslinked Carboxymethyl Chitosan Resin, the internal and area load nano titanium oxide at microsphere, and then obtain nanometer titanium dioxide Titanium-carboxymethyl chitosan complex microsphere.This complex microsphere by the anti-sunlight function of nano titanium oxide, moisture absorption that chitosan is good, The effect such as moisturizing, skin moistening combines, and not only overcomes the problems such as Conventional nano titanium dioxide is easily reunited, consumption is big, and both Combination there is good Synergistic antimicrobial and antiseptic effect.
The present invention has such advantages as relative to prior art and effect:
(1) the component nano titanium oxide-carboxymethyl chitosan complex microsphere of the sun-proof moisturizer that the present invention provides, this is micro- The effects such as the anti-sunlight function of nano titanium oxide, moisture absorption that chitosan is good, moisturizing, skin moistening are combined by ball.
(2) the component nano titanium oxide-carboxymethyl chitosan complex microsphere of the sun-proof moisturizer that invention provides has many Permeability and slow-releasing, stability and persistency to sun-proof moisturizer have higher enhancement effect.
(3) the sun-proof moisturizer that the present invention provides also comprises component Flos persicae extract and Flos Lonicerae extract, and both combine Nano titanium oxide-carboxymethyl chitosan complex microsphere, is absorbing ultraviolet, is removing free radical, suppression melanin generation, suppression The aspects such as Anaphylactic mediator release, protection fibroblast and suppression matrix metal proteinase activity have good resultant effect, Can all band high-selenium corn ultraviolet.
(4) the sun-proof moisturizer that the present invention provides is without adding preservative, safety.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Flos persicae extract (content 10:1) is purchased from Cao Cuixin bio tech ltd, Xi'an；
Flos Lonicerae extract (chlorogenic acid content more than 80%) is purchased from Yuan Sen bio tech ltd, Xi'an；
Embodiment 1
A kind of sun-proof moisturizer, comprises following component the most in parts by mass:
The preparation method of described sun-proof moisturizer, comprises the steps of:
(1) it is 6 × 10 by viscosity-average molecular weight4Chitosan and dehydrated alcohol according to mass volume ratio (g:ml) 1:30 mix Close, supersound process 15min, be subsequently adding the sodium hydroxide solution that mass fraction is 40%, basification under the conditions of 4 DEG C 4.5h；Being then slowly added into monoxone, under the conditions of 65 DEG C, stirring reaction 5h, obtains the carboxymethyl chitosan that substitution value is 1.45； Wherein, chitosan is 1:5 with the mass ratio of sodium hydroxide in sodium hydroxide solution；Chitosan and chloroacetic mass ratio are 1:4；
(2) carboxymethyl chitosan that step (1) prepares is dissolved in water, obtains the carboxymethyl chitosan that mass fraction is 15% Solution, is dispersed in the nano titanium oxide that mean diameter is 50～60nm in carboxymethyl chitosan solution, the most dropwise Join in the liquid paraffin containing span-80,42 DEG C of stir process, form w/o type emulsion；Add chemical cross-linking agent capital Buddhist nun Flat, cross-linking and curing reaction 3.5h under conditions of 45 DEG C, centrifugal, washing, obtain nano titanium oxide-carboxymethyl chitosan and be combined Microsphere (nano titanium oxide is 9:1 with the mass ratio of carboxymethyl chitosan)；Wherein, the consumption of span-80 is liquid paraffin matter The 1.5% of amount；The consumption of genipin is the 37% of carboxymethyl chitosan quality；Carboxymethyl chitosan solution and the matter of liquid paraffin Amount ratio is 1:9；
(3) by Cyclomethicone, isononyl isononanoate, spermol, methyl sesquistearate and glycerol Stearate mixes in oil phase pot, and at 70 DEG C, the mixing of heated and stirred 50min, obtains product 1；
(4) glycerol, pantothenylol, nicotiamide, xanthan gum, essence and water are mixed in aqueous phase pot, heated and stirred at 70 DEG C 35min mixes, and obtains product 2；
(5) under agitation, the product 2 that the product 1 step (3) prepared prepares with step (4) mixes, and vacuum is equal Matter emulsifying 12min, obtains product 3；
(6), after the product that step (5) prepares being cooled to 37 DEG C, (step (2) prepares with remaining component of sun-proof moisturizer Nano titanium oxide-modification of chitosan complex microsphere, Flos persicae extract and Flos Lonicerae extract) mix homogeneously, obtain sun-proof Moisturizer.
Embodiment 2
A kind of sun-proof moisturizer, comprises following component the most in parts by mass:
The preparation method of described sun-proof moisturizer, comprises the steps of:
(1) it is 0.8 × 10 by viscosity-average molecular weight4Chitosan and dehydrated alcohol according to mass volume ratio (g:ml) 1:25 mix Close, supersound process 20min, be subsequently adding the sodium hydroxide solution that mass fraction is 45%, basification 4h under the conditions of 10 DEG C； Being then slowly added into monoxone, under the conditions of 60 DEG C, stirring reaction 6h, obtains the carboxymethyl chitosan that substitution value is 1.26；Wherein, Chitosan is 1:4 with the mass ratio of sodium hydroxide in sodium hydroxide solution；Chitosan and chloroacetic mass ratio are 1:3；
(2) carboxymethyl chitosan that step (1) prepares is dissolved in water, obtains the carboxymethyl chitosan that mass fraction is 10% Solution, is dispersed in the nano titanium oxide that mean diameter is 40～50nm in carboxymethyl chitosan solution, the most dropwise Join in the liquid paraffin containing span-80,40 DEG C of stir process, form w/o type emulsion；Add chemical cross-linking agent capital Buddhist nun Flat, cross-linking and curing reaction 4h under conditions of 40 DEG C, centrifugal, washing, obtain nano titanium oxide-carboxymethyl chitosan and be combined micro- (nano titanium oxide is 8:1 with the mass ratio of carboxymethyl chitosan to ball；Wherein, the consumption of span-80 is liquid paraffin quality 1%；The consumption of genipin is the 35% of carboxymethyl chitosan quality；Carboxymethyl chitosan solution with the mass ratio of liquid paraffin is 1:8；
(3) by Cyclomethicone, isononyl isononanoate, spermol, methyl sesquistearate and glycerol Stearate mixes in oil phase pot, and at 60 DEG C, the mixing of heated and stirred 60min, obtains product 1；
(4) glycerol, pantothenylol, nicotiamide, xanthan gum, essence and water are mixed in aqueous phase pot, heated and stirred at 60 DEG C 40min mixes, and obtains product 2；
(5) under agitation, the product 2 that the product 1 step (3) prepared prepares with step (4) mixes, and vacuum is equal Matter emulsifying 10min, obtains product 3；
(6), after the product that step (5) prepares being cooled to 30 DEG C, (step (2) prepares with remaining component of sun-proof moisturizer Nano titanium oxide-modification of chitosan complex microsphere, Flos persicae extract and Flos Lonicerae extract) mix homogeneously, obtain sun-proof Moisturizer.
Embodiment 3
A kind of sun-proof moisturizer, comprises following component the most in parts by mass:
The preparation method of described sun-proof moisturizer, comprises the steps of:
(1) it is 16 × 10 by viscosity-average molecular weight4Chitosan and dehydrated alcohol according to mass volume ratio (g:ml) 1:50 mix Close, supersound process 10min, be subsequently adding the sodium hydroxide solution that mass fraction is 45%, basification 5h under the conditions of 0 DEG C； Being then slowly added into monoxone, under the conditions of 70 DEG C, stirring reaction 3h, obtains the carboxymethyl chitosan that substitution value is 1.36；Wherein, Chitosan is 1:6 with the mass ratio of sodium hydroxide in sodium hydroxide solution；Chitosan and chloroacetic mass ratio are 1:5；
(2) carboxymethyl chitosan that step (1) prepares is dissolved in water, obtains the carboxymethyl chitosan that mass fraction is 20% Solution, is dispersed in the nano titanium oxide that mean diameter is 50～80nm in carboxymethyl chitosan solution, the most dropwise Join in the liquid paraffin containing span-80,45 DEG C of stir process, form w/o type emulsion；Add chemical cross-linking agent capital Buddhist nun Flat, cross-linking and curing reaction 3h under conditions of 50 DEG C, centrifugal, washing, obtain nano titanium oxide-carboxymethyl chitosan and be combined micro- Ball (nano titanium oxide is 10:1 with the mass ratio of carboxymethyl chitosan)；Wherein, the consumption of span-80 is liquid paraffin quality 2%；The consumption of genipin is the 40% of carboxymethyl chitosan quality；Carboxymethyl chitosan solution and the mass ratio of liquid paraffin For 1:10；
(3) by Cyclomethicone, isononyl isononanoate, spermol, methyl sesquistearate and glycerol Stearate mixes in oil phase pot, and at 80 DEG C, the mixing of heated and stirred 30min, obtains product 1；
(4) glycerol, pantothenylol, nicotiamide, xanthan gum, essence and water are mixed in aqueous phase pot, heated and stirred at 80 DEG C 30min mixes, and obtains product 2；
(5) under agitation, the product 2 that the product 1 step (3) prepared prepares with step (4) mixes, and vacuum is equal Matter emulsifying 15min, obtains product 3；
(6), after the product that step (5) prepares being cooled to 40 DEG C, (step (2) prepares with remaining component of sun-proof moisturizer Nano titanium oxide-modification of chitosan complex microsphere, Flos persicae extract and Flos Lonicerae extract) mix homogeneously, obtain sun-proof Moisturizer.
Comparative example
A kind of sun-proof moisturizer, comprises following component the most in parts by mass:
The preparation method of described sun-proof moisturizer, comprises the steps of:
(1) by Cyclomethicone, isononyl isononanoate, spermol, methyl sesquistearate and glycerol Stearate mixes in oil phase pot, and at 70 DEG C, the mixing of heated and stirred 50min, obtains product 1；
(2) glycerol, pantothenylol, nicotiamide, xanthan gum, essence and water are mixed in aqueous phase pot, heated and stirred at 70 DEG C 35min mixes, and obtains product 2；
(3) under agitation, the product 2 that the product 1 step (1) prepared prepares with step (2) mixes, and vacuum is equal Matter emulsifying 12min, obtains product 3；
(4) after the product that step (3) prepares being cooled to 30 DEG C, with remaining component (nanometer titanium dioxide of sun-proof moisturizer Titanium, chitosan) mix homogeneously, obtain sun-proof moisturizer.
Effect example
(1) mensuration of moisture retention
The practical situation of simulated skin, selects appropriately sized glass dish, weighs a certain amount of sun-proof moisturizer (embodiment 1～3 and comparative example) on glass dish, after putting exsiccator 24h into, be re-weighed, calculate percentage of water loss, percentage of water loss is the least, table Bright moistening effect is the best.Computing formula is as follows:
Percentage of water loss %=(M1-M2) × 100%/M1；
Wherein: M1, product and the weight of surface plate, g before placing；M2, product and the weight of surface plate, g after placement.
Test result shows, the sun-proof moisturizer of embodiment 1～3 preparation, compared to comparative example, has preferably guarantor Wet performance.
The sun-proof moisturizer performance of keeping humidity of table 1 embodiment 1～3 preparation is analyzed
Comparative example Embodiment 1 Embodiment 2 Embodiment 3
Percentage of water loss (%) 17.98 9.25 10.07 10.83
(2) mensuration of sun-proof performance:
To embodiment 1～3 and the product of comparative example carry out sun-proof performance test, after smearing 30min, 60min, 120min measures spf value (uv blocking B ability), the results are shown in Table 2.
The mensuration of the sun-proof performance of sun-proof moisturizer of table 2 embodiment 1～3 preparation
Comparative example Embodiment 1 Embodiment 2 Embodiment 3
Smear rear 30min 22 50 48 47
Smear rear 60min 18 48 47 44
Smear rear 120min 15 46 45 42
Test result shows, the sun-proof moisturizer of embodiment 1～3 preparation, compared to comparative example, has the most anti- UVB ability.
In addition sun protection (concrete grammar reference: the Ma Hong of product under UVC (270nm), three wavelength of UVA (320nm) is measured Rosy clouds. the preparation [J] of the sun-proof moisturizing emulsion of Aloe. Sichuan chemical industry, 2015 (3): 1-3.), result shows: embodiment 1～3 preparation Sun-proof moisturizer, compared to comparative example, has more preferable uv blocking A, UVC ability equally.
(3) repeatedly Skin Irritation Test
Every day, 13:00 smeared the present invention that quality is 5mg, 10mg, 15mg to respectively the mice of tri-groups of back defeatherings of A, B, C Product, application area is 2.5cm × 2.5cm.Smear continuously 14 days, and smear in 8:00,17:00,21:00 observation every day mice Whether place there is the phenomenon such as erythema, edema.Observed result shows: the phenomenon such as erythema, edema all do not occur in 15 mices, show this The product of the present invention is safety non-toxic.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-described embodiment Limit, the change made under other any spirit without departing from the present invention and principle, modify, substitute, combine, simplify, All should be the substitute mode of equivalence, within being included in protection scope of the present invention.

Claims (10)

1. a sun-proof moisturizer, it is characterised in that comprise following component the most in parts by mass:
Sun-proof moisturizer the most according to claim 1, it is characterised in that comprise following component the most in parts by mass:
Sun-proof moisturizer the most according to claim 1 and 2, it is characterised in that:
The preparation method of described nano titanium oxide-carboxymethyl chitosan complex microsphere, comprises the steps of:
(1) chitosan is mixed with dehydrated alcohol, supersound process 10～20min, be subsequently adding sodium hydroxide solution, 0～10 Basification 4～5h under the conditions of DEG C；Being then slowly added into monoxone, under the conditions of 60～70 DEG C, stirring reaction 3～6h, obtains carboxylic first Base enclosure polysaccharide；
(2) carboxymethyl chitosan that step (1) prepares is dissolved in water, obtains carboxymethyl chitosan solution, by nano titanium oxide It is dispersed in carboxymethyl chitosan solution, is then added dropwise in the liquid paraffin containing surfactant, 40～45 DEG C stir process, forms w/o type emulsion；Add chemical cross-linking agent genipin, cross-linking and curing reaction 3 under conditions of 40～50 DEG C ～4h, centrifugal, washing, obtain nano titanium oxide-carboxymethyl chitosan complex microsphere.
Sun-proof moisturizer the most according to claim 3, it is characterised in that:
The viscosity-average molecular weight of the chitosan described in step (1) is 0.8 × 104～16 × 104。
Sun-proof moisturizer the most according to claim 3, it is characterised in that:
Chitosan described in step (1) is 1:(4～6 with the mass ratio of sodium hydroxide in sodium hydroxide solution).
Sun-proof moisturizer the most according to claim 3, it is characterised in that:
Chitosan described in step (1) and chloroacetic mass ratio are 1:(3～5).
Sun-proof moisturizer the most according to claim 3, it is characterised in that:
The substitution value of the carboxymethyl chitosan described in step (1) is not less than 1.
Sun-proof moisturizer the most according to claim 3, it is characterised in that:
The particle diameter of the nano titanium oxide described in step (2) is 40～80nm.
Sun-proof moisturizer the most according to claim 3, it is characterised in that:
Nano titanium oxide and carboxymethyl chitosan in nano titanium oxide described in step (2)-modification of chitosan complex microsphere The mass ratio of sugar is (8～10): 1.
10. the preparation method of the sun-proof moisturizer described in any one of claim 1～9, it is characterised in that comprise the steps of:
(1) by Cyclomethicone, isononyl isononanoate, spermol, methyl sesquistearate and glyceryl stearate Acid esters mixes, and at 60～80 DEG C, heated and stirred mixing, obtains product 1；
(2) glycerol, pantothenylol, nicotiamide, xanthan gum, essence and water being mixed, at 60～80 DEG C, heated and stirred mixing, is produced Thing 2；
(3) under agitation, the product 2 that the product 1 step (1) prepared prepares with step (2) mixes, and vacuum homogenized milk Change, obtain product 3；
(4), after prepared for step (3) product being cooled to 30～40 DEG C, mix homogeneously with remaining component of sun-proof moisturizer, obtain Sun-proof moisturizer.
CN201610962258.9A 2016-11-04 2016-11-04 A kind of sun-proof moisturizer and preparation method and application Pending CN106265391A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108042476A (en) * 2018-02-01 2018-05-18 广州鹰远生物科技有限公司 A kind of lotion containing Flos persicae extract
CN109464348A (en) * 2018-11-22 2019-03-15 赛杜恳医药生物科技（上海）有限公司 A kind of creme and preparation method thereof with beauty and improvement subhealth symptom
CN110051546A (en) * 2019-05-07 2019-07-26 绵阳师范学院 For TiO in cosmetics2The preparation method of careless thuja acid complex microsphere
CN111956590A (en) * 2020-09-29 2020-11-20 南京飞天一淼科技服务有限公司 Slow-release long-acting whitening sunscreen cream and preparation method thereof
CN113499282A (en) * 2021-07-15 2021-10-15 厦门大学 Sunscreen agent based on gold nanoparticle load and preparation method thereof
CN114569526A (en) * 2022-03-03 2022-06-03 广东英腾生物科技有限公司 Anti-wrinkle whitening essence and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101700217A (en) * 2009-09-16 2010-05-05 许庆华 Attapulgite Chinese medicinal herb sun protection cream
CN102018637A (en) * 2009-09-17 2011-04-20 天津科技大学 Preparation of novel sunscreen and moisturizing cream
CN102210634A (en) * 2010-04-09 2011-10-12 上海轻工业研究所有限公司 Sunscreen and gel composition, preparation method and application thereof
CN102525830A (en) * 2011-08-01 2012-07-04 中国人民解放军第八五医院 Sunscreen cream and preparation method thereof
CN103726319A (en) * 2013-12-09 2014-04-16 科凯精细化工（上海）有限公司 Nano-TiO2 loaded chitosan compound and preparation method thereof
CN104784086A (en) * 2015-05-14 2015-07-22 中国热带农业科学院农产品加工研究所 Freckle-removing complex nanosome as well as preparation method and application thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101700217A (en) * 2009-09-16 2010-05-05 许庆华 Attapulgite Chinese medicinal herb sun protection cream
CN102018637A (en) * 2009-09-17 2011-04-20 天津科技大学 Preparation of novel sunscreen and moisturizing cream
CN102210634A (en) * 2010-04-09 2011-10-12 上海轻工业研究所有限公司 Sunscreen and gel composition, preparation method and application thereof
CN102525830A (en) * 2011-08-01 2012-07-04 中国人民解放军第八五医院 Sunscreen cream and preparation method thereof
CN103726319A (en) * 2013-12-09 2014-04-16 科凯精细化工（上海）有限公司 Nano-TiO2 loaded chitosan compound and preparation method thereof
CN104784086A (en) * 2015-05-14 2015-07-22 中国热带农业科学院农产品加工研究所 Freckle-removing complex nanosome as well as preparation method and application thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
于广利 等: "《糖药物学》", 30 September 2012, 中国海洋大学出版社 *
王琼: "纳米氧化锌与壳聚糖复合材料的研究", 《中国优秀硕士学位论文全文数据库工程科技I辑》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108042476A (en) * 2018-02-01 2018-05-18 广州鹰远生物科技有限公司 A kind of lotion containing Flos persicae extract
CN109464348A (en) * 2018-11-22 2019-03-15 赛杜恳医药生物科技（上海）有限公司 A kind of creme and preparation method thereof with beauty and improvement subhealth symptom
CN110051546A (en) * 2019-05-07 2019-07-26 绵阳师范学院 For TiO in cosmetics2The preparation method of careless thuja acid complex microsphere
CN111956590A (en) * 2020-09-29 2020-11-20 南京飞天一淼科技服务有限公司 Slow-release long-acting whitening sunscreen cream and preparation method thereof
CN111956590B (en) * 2020-09-29 2023-09-19 广东修身堂美容科技有限公司 Sustained-release long-acting whitening sun cream and preparation method thereof
CN113499282A (en) * 2021-07-15 2021-10-15 厦门大学 Sunscreen agent based on gold nanoparticle load and preparation method thereof
CN113499282B (en) * 2021-07-15 2022-11-08 厦门大学 Sunscreen agent based on gold nanoparticle load and preparation method thereof
CN114569526A (en) * 2022-03-03 2022-06-03 广东英腾生物科技有限公司 Anti-wrinkle whitening essence and preparation method thereof
CN114569526B (en) * 2022-03-03 2023-12-05 广东英腾生物科技有限公司 Anti-wrinkle whitening essence and preparation method thereof

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Application publication date: 20170104