CN114191349A - Anti-aging composition and preparation method and application thereof - Google Patents
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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Abstract
The invention relates to an anti-aging composition which comprises the following components in percentage by mass: 2-10% of total asiaticoside; 5-20% of secondary cracking yeast fermentation liquor; 5-20% of vitreous origin; 0.7-9% of antioxidant; 10-30% of butanediol; 20-80% of water. The preparation method of the anti-aging composition comprises the following steps: s1: uniformly mixing the asiaticoside and the butanediol at 40-50 ℃ to obtain a solution A; s2: mixing and uniformly stirring the saccharomyces cerevisiae fermentation liquor, the vitriol, the resveratrol, the ergothioneine, the astaxanthin and the water to obtain a solution B; s3: and uniformly mixing the solution A and the solution B to obtain the anti-aging composition. The asiaticoside in the composition can effectively promote the generation of skin collagen, improve the elasticity and the oxidation resistance of the skin and enable the skin to have the anti-aging effect, and the composition does not contain preservatives and is not easy to cause skin sensitivity or damage.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-aging composition and a preparation method and application thereof.
Background
With the development of times, the pressure of work and life is getting bigger and bigger, and people often stay up all night, so that mental stress and insomnia appear in many people, and the skin is premature and old. The influence of air pollution on the atmosphere makes the intensity of the solar ultraviolet rays transmitting through the atmosphere stronger and stronger, and also accelerates the aging of the skin.
The anti-aging cosmetic sold in the market at present uses a plurality of chemically synthesized raw materials, chemically synthesized essence and preservatives. Causing skin damage and allergy to many people.
Disclosure of Invention
In order to solve the problems of skin damage and easy allergy caused by the existing cosmetics, the invention provides an anti-aging and beautifying Chinese herbal medicine composition, a preparation method and application thereof.
In a first aspect, the present application provides an anti-aging composition, comprising the following components in percentage by mass:
2-10% of total asiaticoside;
5-20% of secondary cracking yeast fermentation liquor;
5-20% of vitreous origin;
0.7-9% of antioxidant;
10-30% of butanediol;
20-80% of water.
Further, the antioxidant comprises resveratrol, and the mass percent of the resveratrol is 0.5-5%.
Further, the antioxidant also comprises ergothioneine, and the mass percent of the ergothioneine is 0.2-2%.
Further, the antioxidant also comprises astaxanthin, and the mass percent of the astaxanthin is 0.1-2%.
Further, the total asiaticoside accounts for 4-8% by weight.
Further, the mass percentage of the secondary fission yeast fermentation liquid is 8-16%.
Further, the mass percent of the vitreous color factor is 8-16%.
Further, the mass percent of the antioxidant is 0.7-9%.
In a second aspect, the present invention also provides a method for preparing an antiaging composition as described in the first aspect, which comprises the steps of:
s1: uniformly mixing the asiaticoside and the butanediol at 40-50 ℃ to obtain a solution A;
s2: mixing and uniformly stirring the saccharomyces cerevisiae fermentation liquor, the vitriol, the resveratrol, the ergothioneine, the astaxanthin and the water to obtain a solution B;
s3: and uniformly mixing the solution A and the solution B to obtain the anti-aging composition.
In a third aspect, the present invention also provides a use of an anti-aging composition according to the first aspect: adding the anti-aging composition to a mask, cream, lotion or essence.
In summary, the present application has the following beneficial effects:
1. the centella asiatica total glycosides are extracted from centella asiatica, which is a common traditional Chinese medicine collected in Chinese pharmacopoeia, is a whole plant of centella asiatica of Umbelliferae, and has the effects of clearing heat, promoting diuresis, detoxifying and reducing swelling. Herba Centellae has effects of promoting skin collagen production, improving skin elasticity and resisting oxidation), promoting wound healing, softening scar, etc.
2. The yeast fermentation broth of the invention contains abundant active micromolecules such as vitamins, minerals, amino acids, polysaccharides, polypeptides and the like. Amino acids are contained in the skin itself, and various free amino acids are important components of the natural skin moisturizing factor. The polypeptide, amino acid and other ingredients have a good effect of inhibiting the formation of the melanin of the neuraminidase, and thus are very effective in improving the skin's dark yellow color or spots. Meanwhile, the vitamin B complex is rich in vitamin B group, B5 has the effects of diminishing inflammation and repairing, B3 (nicotinamide) can resist oxidation, inflammation and aging, and certain polysaccharide components (beta glucan) also have the effect of diminishing inflammation. Most of the organic acids contained in the cosmetic are weakly acidic, and can also play a role in mildly removing cutin.
3. The inventive vitreochrome, hydroxypropyl tetrahydropyrane triol, which enters the skin, promotes the production and construction of what is known as protein polysaccharides in the extracellular matrix (e.g., gelatinous protein networks and sugars that act as scaffolds and intercellular shock absorbers). These molecules absorb water, making the matrix gel-like, increasing the firmness of the cells and skin. It may also serve as a channel for the passage of repair molecules, such as proteins for cell growth. As skin ages, the extracellular matrix gradually loses elasticity; the cells begin to deteriorate and are unable to reproduce the youthful state promoting proteins, such as collagen. Vitrescence informs the aged cells of how to do by using the activity of the extracellular matrix, and transmits information to the young cells while re-stimulating the aged cells.
4. The oxidant of the invention comprises natural oxidants of resveratrol and astaxanthin and ergothioneine. The natural antioxidant of resveratrol in plants is mainly derived from grape, giant knotweed, peanut, mulberry and other plants, and plays a role in resisting oxidation mainly through mechanisms of eliminating or inhibiting the generation of free radicals, inhibiting lipid peroxidation, regulating the activity of enzyme related to the oxidation resistance and the like. Astaxanthin is a carotenoid, a strong natural antioxidant, belongs to a fat-soluble and water-soluble pigment, and can be found in marine organisms such as shrimps, crabs, salmon, algae, and the like. Ergothioneine can be transported into cells and mitochondria through a transporter OCTN-1 in keratinocytes and fibroblasts, active oxygen free radicals are eliminated, and therefore effects of resisting oxidation, reducing apoptosis, improving cell activity and protecting cells are achieved, fine wrinkles can be effectively reduced, skin roughness is improved, and skin elasticity is improved.
Detailed Description
Example 1
An anti-aging composition comprises the following components in percentage by mass:
2% of total asiaticoside;
5% of secondary cracking yeast fermentation liquor;
5% of vitreous origin;
0.5 percent of resveratrol;
0.2% of ergothioneine;
0.1% of astaxanthin;
15% of butanediol;
and 72.2 percent of water.
The preparation method of the anti-aging composition comprises the following steps:
s1: uniformly mixing the asiaticoside and the butanediol at 40 ℃ to obtain a solution A;
s2: mixing and uniformly stirring the saccharomyces cerevisiae fermentation liquor, the vitriol, the resveratrol, the ergothioneine, the astaxanthin and the water to obtain a solution B;
s3: and uniformly mixing the solution A and the solution B to obtain the anti-aging composition.
Example 2
An anti-aging composition comprises the following components in percentage by mass:
10% of total asiaticoside;
20% of secondary cracking yeast fermentation liquor;
vitreous opalescence is 20%;
5% of resveratrol;
2% of ergothioneine;
2% of astaxanthin;
30% of butanediol;
11% of water.
The preparation method of the anti-aging composition comprises the following steps:
s1: uniformly mixing the asiaticoside and the butanediol at 50 ℃ to obtain a solution A;
s2: mixing and uniformly stirring the saccharomyces cerevisiae fermentation liquor, the vitriol, the resveratrol, the ergothioneine, the astaxanthin and the water to obtain a solution B;
s3: and uniformly mixing the solution A and the solution B to obtain the anti-aging composition.
Example 3
An anti-aging composition comprises the following components in percentage by mass:
5% of asiaticoside;
13% of secondary cracking yeast fermentation liquor;
vitreous origin 13%;
3% of resveratrol;
1% of ergothioneine;
1% of astaxanthin;
20% of butanediol;
and (5) 42 percent of water.
The preparation method of the anti-aging composition comprises the following steps:
s1: uniformly mixing the asiaticoside and the butanediol at 45 ℃ to obtain a solution A;
s2: mixing and uniformly stirring the saccharomyces cerevisiae fermentation liquor, the vitriol, the resveratrol, the ergothioneine, the astaxanthin and the water to obtain a solution B;
s3: and uniformly mixing the solution A and the solution B to obtain the anti-aging composition.
Example 4
An anti-aging composition comprises the following components in percentage by mass:
4% of asiaticoside;
8% of secondary cracking yeast fermentation liquor;
vitreous origin 8%;
3% of resveratrol;
1% of ergothioneine;
1% of astaxanthin;
20% of butanediol;
55% of water.
The preparation method of the anti-aging composition comprises the following steps:
s1: uniformly mixing the asiaticoside and the butanediol at 45 ℃ to obtain a solution A;
s2: mixing and uniformly stirring the saccharomyces cerevisiae fermentation liquor, the vitriol, the resveratrol, the ergothioneine, the astaxanthin and the water to obtain a solution B;
s3: and uniformly mixing the solution A and the solution B to obtain the anti-aging composition.
Example 5
An anti-aging composition comprises the following components in percentage by mass:
8% of centella total glycosides;
16% of secondary split yeast fermentation liquor;
vitreous origin 16%;
3% of resveratrol;
1% of ergothioneine;
1% of astaxanthin;
20% of butanediol;
35% of water.
The preparation method of the anti-aging composition comprises the following steps:
s1: uniformly mixing the asiaticoside and the butanediol at 45 ℃ to obtain a solution A;
s2: mixing and uniformly stirring the saccharomyces cerevisiae fermentation liquor, the vitriol, the resveratrol, the ergothioneine, the astaxanthin and the water to obtain a solution B;
s3: and uniformly mixing the solution A and the solution B to obtain the anti-aging composition.
Example 6
An anti-aging composition comprises the following components in percentage by mass:
6 percent of asiaticoside;
12% of secondary cracking yeast fermentation liquor;
vitreous origin 12%;
5% of resveratrol;
2% of ergothioneine;
1% of astaxanthin;
20% of butanediol;
and (5) 42 percent of water.
The preparation method of the anti-aging composition comprises the following steps:
s1: uniformly mixing the asiaticoside and the butanediol at 45 ℃ to obtain a solution A;
s2: mixing and uniformly stirring the saccharomyces cerevisiae fermentation liquor, the vitriol, the resveratrol, the ergothioneine, the astaxanthin and the water to obtain a solution B;
s3: and uniformly mixing the solution A and the solution B to obtain the anti-aging composition.
Example 7
An anti-aging composition comprises the following components in percentage by mass:
6 percent of asiaticoside;
12% of secondary cracking yeast fermentation liquor;
vitreous origin 12%;
3% of resveratrol;
0.6 percent of ergothioneine;
1.2% of astaxanthin;
20% of butanediol;
and 45.2 percent of water.
The preparation method of the anti-aging composition comprises the following steps:
s1: uniformly mixing the asiaticoside and the butanediol at 45 ℃ to obtain a solution A;
s2: mixing and uniformly stirring the saccharomyces cerevisiae fermentation liquor, the vitriol, the resveratrol, the ergothioneine, the astaxanthin and the water to obtain a solution B;
s3: and uniformly mixing the solution A and the solution B to obtain the anti-aging composition.
Application example 1
The anti-aging and beautifying Chinese herbal medicine composition disclosed in the embodiment 1 is added into essence, and the addition amount of the anti-aging and beautifying Chinese herbal medicine composition is 10%.
Application example 2
The anti-aging and beautifying Chinese herbal medicine composition disclosed in the embodiment 2 is added into essence, and the addition amount of the anti-aging and beautifying Chinese herbal medicine composition is 10%.
Application example 3
The anti-aging and beautifying Chinese herbal medicine composition disclosed in the embodiment 3 is added into essence, and the addition amount of the anti-aging and beautifying Chinese herbal medicine composition is 10%.
Application example 4
The anti-aging and beautifying Chinese herbal medicine composition disclosed in the embodiment 4 is added into essence, and the addition amount of the anti-aging and beautifying Chinese herbal medicine composition is 10%.
Application example 5
The anti-aging and beautifying Chinese herbal medicine composition disclosed in the embodiment 5 is added into essence, and the addition amount of the anti-aging and beautifying Chinese herbal medicine composition is 10%.
Application example 6
The anti-aging and beautifying Chinese herbal medicine composition disclosed in the embodiment 6 is added into essence, and the addition amount of the anti-aging and beautifying Chinese herbal medicine composition is 10%.
Application example 7
The anti-aging and beautifying Chinese herbal medicine composition disclosed in the embodiment 7 is added into essence, and the addition amount of the anti-aging and beautifying Chinese herbal medicine composition is 10%.
Comparative example 1
Some commercially available anti-aging essence.
Performance test
60 volunteers of 20-60 years old were recruited, all of them were randomly divided into six groups of 10 persons each, and the first group used an existing product, which is an anti-aging essence purchased on the market. The second to sixth groups used the essences of application examples 3 to 7, respectively, 1 time per day for 10 consecutive days. The results of the measurements after 10 days are shown in Table 1:
TABLE 1
As can be seen from table 1, the first group has a general skin improvement effect when compared with the second to sixth groups, which effectively shows that the product of the present invention has outstanding effects and advantages compared with the existing products in the market.
In conclusion, the asiaticoside is extracted from centella asiatica, which is a common traditional Chinese medicine collected in Chinese pharmacopoeia, is a whole plant of centella asiatica of Umbelliferae, and has the effects of clearing heat, promoting diuresis, detoxifying and reducing swelling. Centella asiatica has the effects of promoting wound healing, softening scars and the like. The yeast fermentation broth of the invention contains abundant active micromolecules such as vitamins, minerals, amino acids, polysaccharides, polypeptides and the like. Amino acids are contained in the skin itself, and various free amino acids are important components of the natural skin moisturizing factor. The polypeptide, amino acid and other ingredients have a good effect of inhibiting the formation of the melanin of the neuraminidase, and thus are very effective in improving the skin's dark yellow color or spots. Meanwhile, the vitamin B complex is rich in vitamin B group, B5 has the effects of diminishing inflammation and repairing, B3 (nicotinamide) can resist oxidation, inflammation and aging, and certain polysaccharide components (beta glucan) also have the effect of diminishing inflammation. Most of the organic acids contained in the cosmetic are weakly acidic, and can also play a role in mildly removing cutin. The inventive vitreochrome, hydroxypropyl tetrahydropyrane triol, which enters the skin, promotes the production and construction of what is known as protein polysaccharides in the extracellular matrix (e.g., gelatinous protein networks and sugars that act as scaffolds and intercellular shock absorbers). These molecules absorb water, making the matrix gel-like, increasing the firmness of the cells and skin. It may also serve as a channel for the passage of repair molecules, such as proteins for cell growth. As skin ages, the extracellular matrix gradually loses elasticity; the cells begin to deteriorate and are unable to reproduce the youthful state promoting proteins, such as collagen. Vitrescence informs the aged cells of how to do by using the activity of the extracellular matrix, and transmits information to the young cells while re-stimulating the aged cells. The oxidant of the invention comprises natural oxidants of resveratrol and astaxanthin and ergothioneine. The natural antioxidant of resveratrol in plants is mainly derived from grape, giant knotweed, peanut, mulberry and other plants, and plays a role in resisting oxidation mainly through mechanisms of eliminating or inhibiting the generation of free radicals, inhibiting lipid peroxidation, regulating the activity of enzyme related to the oxidation resistance and the like. Astaxanthin is a carotenoid, a strong natural antioxidant, belongs to a fat-soluble and water-soluble pigment, and can be found in marine organisms such as shrimps, crabs, salmon, algae, and the like. Ergothioneine can be transported into cells and mitochondria through a transporter OCTN-1 in keratinocytes and fibroblasts, active oxygen free radicals are eliminated, and therefore effects of resisting oxidation, reducing apoptosis, improving cell activity and protecting cells are achieved, skin color spots and fine lines can be effectively reduced, skin roughness is improved, and skin elasticity is improved.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (10)
1. The anti-aging composition is characterized by comprising the following components in percentage by mass:
2. the anti-aging composition according to claim 1, wherein:
the antioxidant comprises resveratrol, and the mass percent of the resveratrol is 0.5-5%.
3. The anti-aging composition according to claim 2, wherein:
the antioxidant also comprises ergothioneine, and the mass percent of the ergothioneine is 0.2-2%.
4. The anti-aging composition according to claim 3, wherein:
the antioxidant also comprises astaxanthin, and the mass percent of the astaxanthin is 0.1-2%.
5. The anti-aging composition according to claim 1, wherein:
the mass percentage of the total asiaticoside is 4-8%.
6. The anti-aging composition according to claim 1, wherein:
the mass percentage of the secondary fission yeast fermentation liquid is 8-16%.
7. The anti-aging composition according to claim 1, wherein:
the mass percentage of the vitreous color factor is 8-16%.
8. The anti-aging composition according to claim 1, wherein:
the mass percent of the antioxidant is 0.7-9%.
9. A method of preparing an anti-aging composition according to any one of claims 1 to 8, comprising the steps of:
s1: uniformly mixing the asiaticoside and the butanediol at 40-50 ℃ to obtain a solution A;
s2: mixing and uniformly stirring the saccharomyces cerevisiae fermentation liquor, the vitriol, the resveratrol, the ergothioneine, the astaxanthin and the water to obtain a solution B;
s3: and uniformly mixing the solution A and the solution B to obtain the anti-aging composition.
10. Use of an anti-ageing composition according to any one of claims 1 to 7, wherein:
adding the anti-aging composition to a mask, cream, lotion or essence.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115040429A (en) * | 2022-07-18 | 2022-09-13 | 华熙生物科技股份有限公司 | Anti-aging composition and application thereof |
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