CN115300433B - Eye mask essence with whitening and repairing effects and preparation method and application thereof - Google Patents
Eye mask essence with whitening and repairing effects and preparation method and application thereof Download PDFInfo
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- CN115300433B CN115300433B CN202211130135.0A CN202211130135A CN115300433B CN 115300433 B CN115300433 B CN 115300433B CN 202211130135 A CN202211130135 A CN 202211130135A CN 115300433 B CN115300433 B CN 115300433B
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- eye mask
- essence
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- whitening
- mixture
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Abstract
The invention discloses an eye mask essence with whitening and repairing effects, and a preparation method and application thereof, and belongs to the technical field of skin care products. The eye mask essence comprises the following components in parts by weight: 0.1 to 2 parts of inula flower extract, 0.1 to 1 part of nicotinamide, 0.1 to 10 parts of eight-treasure essence stock solution, 0.1 to 5 parts of acetylglucosamine, 0.1 to 3 parts of hydroxyethyl piperazine ethane sulfonic acid, 0.01 to 5 parts of purslane extract, 0.01 to 1 part of rhodiola root extract, 0.1 to 5 parts of panthenol, 0.1 to 5 parts of oat beta-glucan, 0.01 to 0.5 part of sodium hyaluronate, 0.1 to 5 parts of glyceroglycosides, 0.1 to 1 part of dipotassium glycyrrhizinate, 0.1 to 5 parts of pine red recheck essence and 0.01 to 2 parts of ginseng plum ferment. The eye mask essence has whitening and repairing effects, and the components complement each other under the synergistic effect, so that the prepared product has whitening and repairing effects at the same time and good high-temperature stability.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to an eye mask essence with whitening and repairing effects, and a preparation method and application thereof.
Background
The skin around the eyes is the weakest part of human skin, and the thickness of the epidermis and the dermis is far less than that of facial skin, so that the skin is easily damaged by the outside. The most common problems of the eye skin are dark circles and damaged eye skin, wherein most of the dark circles are caused by insufficient sleep or overfatigue, the eye skin gradually loses elasticity due to ultraviolet injury, skin aging and the like, the eye sockets are deeply sunk to cause the dark circles, or skin around the eyes is inflamed due to improper use of cosmetics, and pigmentation after inflammation is caused. In addition, with the increase of age and life pressure, factors such as sunlight, artificial light irradiation, air pollution, dust, particles and the like in computers and environments can cause accelerated aging of the skin around the eyes, skin injury and damage to the skin around the eyes, so that moisture loss of the skin around the eyes is caused, the skin around the eyes is easily damaged deeply by external stimulus, and skin sensitive symptoms such as itching, stinging, burning, tightening and the like are easily generated.
Aiming at the problems, the eye whitening products or the eye repairing products are generally adopted for improvement, but most of the whitening repairing products on the market at present have the same components and single functions. For example, patent application publication No. CN111000765 a discloses a whitening composition containing ginseng ferment and application thereof, which comprises the following components in parts by mass: the whitening composition is added into moisturizing water, essence and moisturizing cream, and has the effects of whitening and brightening skin by reasonably matching the alpha-arbutin, the nicotinamide and the ginseng ferment, wherein the inhibiting effect on melanin is remarkable. However, no mention is made in the patent application regarding the efficacy of the composition in skin repair.
Aiming at the problem of single function of the product, the problem of rough character and poor stability of the prepared product is easily caused by adding other functional components, and transdermal absorption is not facilitated, so that the original function of the product is affected, and the overall use experience of a patient is poor.
Therefore, developing an eye product with better whitening and repairing effects and good stability is a problem to be solved at present.
Disclosure of Invention
Aiming at the defects of the prior art, one of the purposes of the invention is to provide an eye mask essence with whitening and repairing effects. The essence has the effects of whitening and repairing at the same time, and the components have synergistic effect, so that the prepared product has the effects of whitening and repairing at the same time, and has good high-temperature stability.
The second aim of the invention is to provide a preparation method of the eye mask essence, which is simple and efficient and is suitable for industrial production and application.
The third object of the invention is to provide an eye mask prepared by combining the eye mask essence and the eye mask base cloth, wherein the eye mask has obvious whitening, brightening and repairing effects.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
in a first aspect, the invention provides an eye mask essence with whitening and repairing effects, which comprises the following preparation raw materials in parts by weight:
in the above technical scheme, the extract of Inula JAPONICA (Inula JAPONICA) contains moisturizing components, so that skin can be moisturized for a long time. The inula flower has good inhibition effect on the proliferation of melanocytes, and reduces the formation of melanin from the source of melanin by inhibiting the activity of the neuraminidase; the whitening functional substances can be simultaneously interacted with collagen and elastin by adding the whitening functional substances into the eye mask essence, so that the whitening functional substances are protected from being hydrolyzed by enzymes, the pigmentation of melanin is effectively prevented, and the effects of whitening, moisturizing and enhancing the skin activity are achieved.
The nicotinamide is a common whitening component, belongs to vitamin derivatives, has the effects of blocking melanin transmission and accelerating new aging, so that melanin deposition in the stratum corneum is reduced, skin blackening is avoided, and clinical tests prove that the nicotinamide can obviously reduce the area and the quantity of brown spots of the skin.
The eight-treasure essence stock solution comprises a ligusticum wallichii root extract, a poria cocos sclerotium extract, a rhizoma atractylodis macrocephalae root extract, a rhizoma bletillae root extract, a radix ampelopsis root extract, artificial bezoar, a pearl extract and borneol, wherein the bezoar has a certain antioxidation function, the borneol has the effects of preventing corrosion and promoting granulation, the pearl has the effects of improving eyesight, soothing nerves, calming wind, promoting granulation and healing sores, and the radix ampelopsis, rhizoma bletillae, bighead atractylodes rhizome, poria cocos and ligusticum wallichii are matched, so that the effects of resisting oxidation, activating blood and dissolving stasis are achieved, and cell injury can be effectively prevented and skin barriers can be effectively repaired.
Specifically, the eight-treasure essence stock solution comprises the following components: 0.8wt% of Ligusticum wallichii (LIGUSTICUM CHUANXIONG) root extract, 0.5wt% of Poria COCOS (PORIA COS) sclerotium extract, 0.5wt% of Atractylodes macrocephala (ATRACTYLODES MACROCEPHALA) root extract, 0.3wt% of BLETILLA STRIATA (Bletilla STRIATA) root extract, 0.3wt% of Ampelopsis japonica (AMPELOPSIS JAPONICA) root extract, 0.05wt% of artificial bezoar, 1wt% of pearl extract, 0.05wt% of borneol, 1wt% of 1, 2-hexanediol, 5wt% of butanediol, 0.5wt% of phenoxyethanol, 0.1wt% of ethylhexyl glycerol and 89.9wt% of water. The eight-treasure essence stock solution is prepared by uniformly mixing the raw materials, filtering and sterilizing.
The chitosan amine is a saccharide with amino, is a product obtained by partially deacetylating chitin, can inhibit the activity of the neuraminidase by inhibiting the glycosylation of the neuraminidase, so as to reduce the generation of melanin, can also produce glucosamine by deacetylation, and can inhibit the generation of melanin by melanocytes in vitro, so as to reduce the generation of melanin, and has good whitening effect.
The hydroxyethyl piperazine ethane sulfonic acid belongs to a weak acid system, can reform the stratum corneum, promote old and old keratinocytes of the skin epidermis layer to peel off, lighten skin color, achieve the whitening effect, promote the absorption of other whitening effect components, and have the synergistic whitening effect with other active components.
The purslane (PORTULACA OLERACEA) extract is rich in polysaccharide and flavonoid compounds with broad-spectrum antibacterial property, has good inhibition effect on common bacteria and fungi, can reduce the dosage of bacteriostats and preservatives when being added into cosmetics, has strong scavenging effect on various free radicals of human bodies, has good antioxidation effect, and contains abundant whitening components such as vitamin E, vitamin C and the like in purslane, which can inhibit the activity of tyrosinase so as to prevent melanin from being generated, thus having good whitening effect.
The RHODIOLA ROSEA (RHODIOLA ROSEA) root extract mainly comprises salidroside and flavonoid compounds, wherein the salidroside belongs to phenolic compounds, and can reduce the damage of ultraviolet radiation to cell membranes, and the flavonoid compounds have better free radical scavenging effect, so that the RHODIOLA ROSEA (RHODIOLA ROSEA) root extract has better antioxidant activity, can effectively improve darkness, lighten skin color, maintain skin stability and have good whitening and repairing effects.
Panthenol is also called provitamin B5, is a precursor of vitamin B5 pantothenic acid, has stable property and good penetrability, is easy to penetrate skin barrier, and a large number of researches show that panthenol is helpful for self-repairing skin, especially can stimulate skin cells to generate, and is helpful for wound healing.
Oat beta-glucan exists in the cell wall of oat bran, is polysaccharide composed of sugar monomers connected by cellotriose and cellotetraose, can promote the acceleration of interleukin-1 released by macrophages on collagen synthesis, promote collagen synthesis, resist aging, reduce skin wrinkles, improve skin elasticity and improve skin texture, and in a word, the oat beta-glucan has good transdermal absorption performance, and can better promote wound healing and repair damaged skin.
Sodium hyaluronate is a good humectant, has the effects of promoting proliferation and differentiation of epidermal cells and scavenging oxygen free radicals, can accelerate regeneration of epidermal cells, promote repair of damaged skin, and make skin tender, smooth and elastic.
The glucosyl glycoside is a glucoside compound formed by connecting glucosyl and glycerol through glycosidic bonds, can penetrate into dermis, has long-acting moisturizing, repairing and relieving effects, has a polyhydroxy structure capable of keeping cell moisture, and has a good moisturizing effect by promoting aquaporin synthesis to comprehensively moisturize cells at a cell level; the glyceroglycosides can also promote the expression of type I collagen, further strengthen skin elasticity and collagen, promote skin barrier repair, and can also obviously reduce the release amount of inflammatory factors such as IL-1 beta, IL-1 alpha and the like, obviously improve the cell healing rate, and have better repairing efficacy.
Dipotassium glycyrrhizinate is a skin conditioner, is mainly glycyrrhizin (glycyrrhizic acid) component of root and stem of Glycyrrhrizae radix, can effectively prevent sensitive inflammation phenomenon when skin is stimulated, has antiinflammatory and tranquilizing effects on inflammation caused by sunlight, and has good antiallergic and repairing effects.
The core component of the pine-red plum re-checking essence is the essential oil which belongs to the genus Bao Zimu of the family Myrtaceae, is a tea tree with broom leaf and Australia, has bright color and is rich in sesquiterpene, sesquiterpene alcohol and sesquiterpene ketone components, and is mainly wild. Modern pharmacological tests show that the pine-red plum compound extract can inhibit TRPV1 and NO generation and inhibit histamine signal paths through the synergistic effect of the components such as pine-red plum, stephania tetrandra and lotus, has obvious repairing function on inflammatory reaction caused by UV, can reduce red swelling caused by UV and chronic inflammation, reduces cell damage caused by stimulation, and has good anti-inflammatory repairing effect.
The ginseng ferment is prepared by taking ginseng as a raw material and then planting beneficial bacteria for fermentation, the ginseng ferment used in the invention consists of butanediol, lactobacillus/ginseng root fermentation product filtrate and hydrolyzed ginsenoside, wherein the ginsenoside can destroy the process of transferring from melanocytes of a basal layer to keratinocytes of an upper layer, inhibit the transfer of melanosomes to keratinocytes, and has good whitening effect; the ginseng ferment can promote normal fibroblast proliferation and migration, is beneficial to wound healing and skin regeneration, can inhibit scar fibroblast proliferation, reduces scar generation in the wound skin healing process, reduces skin atrophy caused by ultraviolet rays, relieves photoaging, and has good repairing effect.
It is to be understood that the above-mentioned eye mask essence may be appropriately added with various components generally used for eye care other than the above-mentioned functional components as needed.
As a further preferable technical scheme of the invention, the preparation raw materials also comprise one or more of polyalcohol, thickener, preservative and deionized water.
As a further preferable mode of the technical scheme of the invention, the consumption of the polyol is 1-20 parts by weight; the consumption of the thickener is 0.1-1 part; the usage amount of the preservative is 0.1-2 parts; the dosage of the deionized water is 10-90 parts.
As a further preferred aspect of the present invention, the polyhydric alcohol is one or more selected from the group consisting of glycerin, propylene glycol, butylene glycol, sorbitol, dipropylene glycol, 1, 3-propanediol, pentylene glycol, and hexylene glycol.
As a further preferred aspect of the present invention, the thickener is one or more selected from carboxymethyl cellulose, hydroxyethyl cellulose and methyl cellulose.
As a further preferred mode of the technical scheme, the preservative is selected from one or more of phenoxyethanol, ethylhexyl glycerol, chlorphenicol, methylparaben, p-hydroxyacetophenone and 1, 2-hexanediol.
In a second aspect, the present invention provides a method for preparing the above eye mask essence, comprising the steps of:
(1) Mixing deionized water, polyalcohol, thickener, sodium hyaluronate and dipotassium glycyrrhizinate, stirring, heating, homogenizing, dispersing uniformly to obtain a mixture 1, and cooling for later use;
(2) Mixing inula flower extract, nicotinamide, acetylglucosamine, hydroxyethyl piperazine ethane sulfonic acid, purslane extract and rhodiola root extract, adding the mixture into the mixture 1 cooled in the step (1), and stirring and uniformly mixing to obtain a mixture 2;
(3) Mixing eight-treasure essence stock solution, pine and red plum composite essence, panthenol, glyceroglucoside, oat beta-glucan and ginseng ferment, adding the mixture into the mixture 2 obtained in the step (2), and stirring and uniformly mixing to obtain a mixture 3;
(4) Adding preservative into the mixture 3 obtained in the step (3), uniformly stirring, and then cooling to normal temperature to obtain the eye mask essence.
As a further preferable mode of the technical scheme of the invention, in the step (1), the temperature is firstly increased to 75-80 ℃ and then is reduced to 40-45 ℃.
In a third aspect, the present invention also provides an eye patch prepared from the above-mentioned eye mask essence and an eye mask base cloth. It is understood that the eye mask is only one form of application of the essence, and can also be prepared into products such as eye cream, eye gel and the like.
Compared with the prior art, the invention has the following beneficial effects:
1. from the two angles of whitening and repairing, nicotinamide, acetylglucosamine, hydroxyethyl piperazine ethane sulfonic acid, purslane extract, rhodiola root extract and eight-treasure essence stock solution are selected as whitening functional components, so that the prepared product has good whitening effect; meanwhile, the repairing components such as panthenol, oat beta-glucan, sodium hyaluronate, glyceroglycosides, dipotassium glycyrrhizinate and pine and red plum are added, so that the repairing efficacy of the product is greatly improved. The various functional components of the invention are not simple superposition combination, but are scientifically and strictly prepared in terms of types and dosage, and the various components complement each other under the synergistic effect, so that the prepared product has the whitening and repairing effects at the same time.
2. Nicotinamide is a recognized whitening component, and has good whitening effect; however, even pure nicotinamide contains nicotinic acid components, and when the amount of nicotinamide is high, intolerance is caused. According to the invention, a plurality of whitening functional components are selected, so that the consumption of nicotinamide is greatly reduced on the premise of ensuring the whitening and repairing effects, and the problem of potential intolerance of products is avoided.
3. In the invention, panthenol, oat beta-glucan, sodium hyaluronate, glyceroglycosides, dipotassium glycyrrhizinate and pine red plum are preferable, and the obtained product has good high-temperature stability due to the fact that the pine red plum is rechecked and refined and the ginseng ferment active ingredients are: the substances in the invention are water-soluble, which is helpful for the penetration of the substances in the skin, and amino groups in the acetylglucosamine, amide bonds in the nicotinamide, hydroxyl groups in the panthenol, glucosides in the glucosides and glucosides in the oat beta-glucan can be combined with water molecules and each other through hydrogen bonds, van der Waals force, so that the stability of the system is ensured.
4. The applicant finds that when the pine-red plum is rechecked and refined and the ginseng ferment are matched for mutual use, the effects of supplementing water and whitening and repairing can be achieved, and the possible reasons are that: active ingredients in the pine-red plum re-checking essence and active ingredients in the ginseng ferment are macromolecular compounds, and the active ingredients and the ginseng ferment can structurally form cavity structures with different sizes and realize water locking to reach different skin parts; meanwhile, the functional components with different penetrability can correspondingly permeate into different skin layers such as a stratum corneum, a transparent layer and the like by being matched with the synergistic use of other substances, so that the overall whitening and water retention of each skin layer are realized.
5. The preparation method provided by the invention is simple and convenient to operate, has strong universality and is suitable for large-scale production.
In a word, the invention makes the prepared product have the whitening and repairing effects at the same time by carefully selecting various whitening and repairing functional components, and solves the problems of identical components and single functions of most whitening and repairing products in the market; and the product has good high-temperature stability and good market application prospect.
Drawings
Fig. 1 is a diagram showing the appearance of the stability test of the product prepared in comparative example 1, wherein (a) is a product subjected to stability inspection at a normal temperature of 25 ℃, (b) is a product subjected to stability inspection under a high-low temperature circulation condition, and (c) is a product subjected to stability inspection at a high temperature of 45 ℃.
Fig. 2 is an apparent chromaticity photograph of the whitening efficacy test, which is a blank control group, a positive control group, a comparative example 1 sample group, and an example 1 sample group in this order from top to bottom.
Detailed Description
The following description of the embodiments of the present invention will clearly and fully describe the technical aspects of the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, are intended to fall within the scope of the present invention.
It should be noted that, in the present invention, part of the substance information is as follows:
the eight-treasure essence stock solution used in the invention is self-produced by major health limited company of Ma Ying Long;
the pine-red plum compound extract and the ginseng ferment used in the invention are purchased from Guangzhou gamma energy biotechnology Co., ltd;
the phenoxyethanol/ethylhexyl glycerol used in the present invention is sold under the trade name euxyl PE 9010.
Example 1
An eye mask essence with whitening and repairing effects is prepared from the following raw materials in parts by weight:
table 1 composition of the raw materials in example 1
The embodiment also provides a preparation method of the eye mask essence, which comprises the following steps:
(1) Mixing deionized water, butanediol, glycerol, hydroxyethyl cellulose, sodium hyaluronate and dipotassium glycyrrhizinate in the component A, stirring and heating to 75 ℃, homogenizing and dispersing uniformly to obtain a mixture 1, and then cooling to 40 ℃ for standby;
(2) Mixing the inula flower extract, nicotinamide, acetylglucosamine, hydroxyethyl piperazine ethane sulfonic acid, purslane extract and rhodiola root extract in the component B, adding the mixture into the mixture 1 cooled in the step (1), and stirring and uniformly mixing to obtain a mixture 2;
(3) Mixing eight-treasure essence stock solution, pine and red plum compound essence, panthenol, glyceroglycosides, oat beta-glucan and ginseng ferment in the component C, adding the mixture into the mixture 2 obtained in the step (2), and stirring and uniformly mixing to obtain a mixture 3;
(4) And (3) adding phenoxyethanol/ethylhexyl glycerol and 1, 2-hexanediol in the component D into the mixture 3 obtained in the step (3), uniformly stirring, and then cooling to normal temperature to obtain the eye mask essence.
And (3) pouring the eye mask essence prepared in the embodiment 1 into an eye mask bag which is pre-filled with eye mask base cloth, thus obtaining an eye mask product.
Example 2
An eye mask essence with whitening and repairing effects is prepared from the following raw materials in parts by weight:
table 2 composition of the raw materials in example 2
The embodiment also provides a preparation method of the eye mask essence, which comprises the following steps:
(1) Mixing deionized water, butanediol, glycerol, hydroxyethyl cellulose, sodium hyaluronate and dipotassium glycyrrhizinate in the component A, stirring and heating to 75 ℃, homogenizing and dispersing uniformly to obtain a mixture 1, and then cooling to 40 ℃ for standby;
(2) Mixing the inula flower extract, nicotinamide, acetylglucosamine, hydroxyethyl piperazine ethane sulfonic acid, purslane extract and rhodiola root extract in the component B, adding the mixture into the mixture 1 cooled in the step (1), and stirring and uniformly mixing to obtain a mixture 2;
(3) Mixing eight-treasure essence stock solution, pine and red plum compound essence, panthenol, glyceroglycosides, oat beta-glucan and ginseng ferment in the component C, adding the mixture into the mixture 2 obtained in the step (2), and stirring and uniformly mixing to obtain a mixture 3;
(4) And (3) adding phenoxyethanol/ethylhexyl glycerol and 1, 2-hexanediol in the component D into the mixture 3 obtained in the step (3), uniformly stirring, and then cooling to normal temperature to obtain the eye mask essence.
And (3) pouring the eye mask essence prepared in the embodiment 2 into an eye mask bag which is provided with eye mask base cloth in advance, thus obtaining an eye mask product.
Example 3
An eye mask essence with whitening and repairing effects is prepared from the following raw materials in parts by weight:
TABLE 3 composition of the raw materials in example 3
The embodiment also provides a preparation method of the eye mask essence, which comprises the following steps:
(1) Mixing deionized water, butanediol, glycerol, hydroxyethyl cellulose, sodium hyaluronate and dipotassium glycyrrhizinate in the component A, stirring and heating to 75 ℃, homogenizing and dispersing uniformly to obtain a mixture 1, and then cooling to 40 ℃ for standby;
(2) Mixing the inula flower extract, nicotinamide, acetylglucosamine, hydroxyethyl piperazine ethane sulfonic acid, purslane extract and rhodiola root extract in the component B, adding the mixture into the mixture 1 cooled in the step (1), and stirring and uniformly mixing to obtain a mixture 2;
(3) Mixing eight-treasure essence stock solution, pine and red plum compound essence, panthenol, glyceroglycosides, oat beta-glucan and ginseng ferment in the component C, adding the mixture into the mixture 2 obtained in the step (2), and stirring and uniformly mixing to obtain a mixture 3;
(4) And (3) adding phenoxyethanol/ethylhexyl glycerol and 1, 2-hexanediol in the component D into the mixture 3 obtained in the step (3), uniformly stirring, and then cooling to normal temperature to obtain the eye mask essence.
And (3) pouring the eye mask essence prepared in the embodiment 3 into an eye mask bag which is pre-filled with eye mask base cloth, thus obtaining an eye mask product.
Comparative example 1
The procedure of example 1 was repeated except that the component C was not supplemented with ginseng ferment and pine-red plum complex essence.
Test example 1: stability test
The eye mask essence prepared in example 1 and comparative example 1 were examined for stability, and the specific test method and results are as follows:
the testing method comprises the following steps: the eye mask essence prepared in example 1 and comparative example 1 were put into transparent plastic bottles, 5 parallel samples were put at low temperature-7 deg.C, low temperature 4 deg.C, cyclic-7 deg.C/45 deg.C/24 h, high temperature 45 deg.C, and normal temperature 25 deg.C for 30 days, respectively.
Stability criterion: and after all samples are restored to room temperature, compared with the samples at the temperature of 4 ℃, the samples are stored at the room temperature and circulated at high and low temperatures, no obvious color change and smell change are caused, and the material body is stable due to no layering phenomenon such as precipitation.
Stability test results: see table 4.
Table 4 results of stability test of the eye mask essence prepared in example 1 and comparative example 1
The test results show that: the product prepared by the embodiment 1 of the invention has no obvious color change and smell change under normal temperature storage and high and low temperature circulation conditions, no abnormality in stability investigation and good product stability; the product prepared in comparative example 1 was subjected to high-low temperature cycle and high-temperature environment, the product was significantly discolored, the liquid color was deepened, and the specific product appearance chart was shown in fig. 1, thus it was found that the product prepared in comparative example 1 was poor in stability.
Test example 2: whitening efficacy test
The whitening efficacy test of the sample is carried out by referring to the standard TSHRH 021-2019 cosmetic whitening efficacy test in vitro recombinant 3D melanin model test method. The test uses a 3D melanin skin modelThe method is characterized in that a surface drug administration mode is adopted for testing tools, a sample to be tested is acted on a 3D melanin skin model, and the whitening efficacy of the sample to be tested is evaluated through indexes of three dimensions of apparent chromaticity, apparent brightness (L) and melanin content of the model after drug administration.
(1) Model drug delivery
From the Day of model reception (Day 1), the positive control group (kojic acid, 42.67. Mu.g/mL), the comparative example 1 sample group, and the example 1 sample group were administered twice at Day1 and Day3, respectively, in a surface administration manner and in a volume of 10. Mu.L. After the model is continuously cultured for 5 days, the sample is collected and is to be measured.
(2) Detection index and method
(1) Apparent chromaticity: after the model cultivation is finished, apparent photographing is carried out by a camera.
(2) L value test: and detecting the L-value of the model after the apparent chromaticity detection is finished. Mean and standard deviation were calculated from the L values of three replicate models per group, and the results were expressed in mean±sd.
(3) Melanin content test: and (3) carrying out melanin content detection on the model after the detection of the L values, and calculating the average value and standard deviation of the melanin content of each group of three repeated models, wherein the result is expressed by mean+/-SD.
(3) Detection result
After model administration, apparent chromaticity detection is carried out, and apparent pictures are shown in fig. 2: compared with the blank control group, the apparent chromaticity of the positive control group model is obviously whitened, which indicates that the test condition is effective. The apparent chromaticity of the skin model after the sample group treatment of example 1 was whitened compared to the blank group.
The model after the apparent chromaticity detection was measured for L-value, and the comparison between the groups was performed by t-test statistical analysis, and the results are shown in table 5. The apparent brightness (L value) of the positive control group was significantly increased (P < 0.01) compared to the blank group, indicating that the test conditions were valid, and the apparent brightness (L value) of the comparative example 1 sample group and the example 1 sample group was significantly increased (P < 0.01). Compared with the positive control group and the comparative example 1 sample group, the apparent brightness (L value) of the example 1 sample group is also extremely obviously increased (P < 0.01), so that the product prepared by the invention has obvious whitening effect.
Table 5 model L x value detection result summary table (mean±sd, n=3)
( And (3) injection: significance is expressed as x, p-value <0.05 is expressed as x, p-value <0.01 is expressed as x )
The melanin content of the model after the detection of the L-value is finished is detected, and the comparison among the groups adopts t-test statistical analysis, and the result is shown in table 6. The positive control group showed very significant decrease in melanin content (P < 0.01) compared to the blank group, indicating that the test conditions were effective, and the melanin content was also very significantly decreased (P < 0.01) in the comparative example 1 sample group and the example 1 sample group. Compared with the positive control group, the melanin content of the sample group in the embodiment 1 is obviously reduced (P < 0.05), so that the product prepared by the embodiment of the invention has obvious whitening effect.
Table 6 melanin content test results summary table (mean±sd, n=3)
( And (3) injection: significance is expressed as x, p-value <0.05 is expressed as x, p-value <0.01 is expressed as x )
Test example 3: repair efficacy test
The invention evaluates the repair efficacy of the eye patches prepared in example 1 and comparative example 1 using a trans-epidermal water loss (TEWL) test, using the following instrumentation, test methods, and test results:
instrument apparatus: skin surface moisture loss instrument tewatter TM 300 (Courage & Khazaka, germany).
The detection method comprises the following steps: randomly selecting 20 subjects with 18-60 years of age, dry eye skin and fragile rough skin barrier, dividing the subjects into 2 groups, and applying the samples to be tested of the example 1 and the comparative example 1 to the periocular skin of each group of subjects for 10-15min respectively, wherein the samples are used for 1 time in the morning and evening. Long-term sun exposure, outdoor exercises, travel, etc. cannot be performed during the entire test period, cosmetics or medicines having similar effects to those of the products must not be used during the entire test period, and the daily care habits of the subjects must not be changed during the test period.
The statistical method comprises the following steps: each subject was tested 3 times to average and the results were expressed as mean±sd, wherein lower TEWL values were obtained indicating less percutaneous water loss.
Test results: see table 7.
Table 7 results of percutaneous moisture loss before and after skin application of the product (mean±sd, n=10) in subjects
(P < 0.05P <0.01 compared to before use of the product)
As can be seen from table 7, the amount of the percutaneous moisture loss at the eye periphery was extremely remarkably reduced (p < 0.01) after 14 days of using the product of example, and the amount of the percutaneous moisture loss was further reduced after 28 days of using the product, and the product was excellent in repairing effect and quick in onset of action; and after the comparative example product is used for 14 days, the moisture loss amount of the skin around eyes is not significantly different, so that the repairing effect of the product of the embodiment of the invention on dry, rough and fragile skin of eyes is far better than that of the comparative example product.
The applicant states that the present invention describes the eye mask essence with whitening and repairing effects and the preparation method thereof through the above embodiments, but the present invention is not limited to the above embodiments, i.e. it does not mean that the present invention must be implemented by the above embodiments. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of individual raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.
Claims (8)
1. The eye mask essence with the whitening and repairing effects is characterized by being prepared from the following raw materials in parts by weight:
wherein the eight-treasure essence stock solution comprises rhizoma Ligustici Chuanxiong root extract, poria sclerotium extract, atractylodis rhizoma root extract, rhizoma Bletillae root extract, radix Ampelopsis extract, artificial bezoar, margarita extract and Borneolum Syntheticum.
2. The eye mask essence according to claim 1, wherein the polyhydric alcohol is one or more selected from the group consisting of glycerin, propylene glycol, butylene glycol, sorbitol, dipropylene glycol, 1, 3-propanediol, pentylene glycol, hexylene glycol.
3. The eye mask essence according to claim 2, wherein the thickener is selected from one or more of carboxymethyl cellulose, hydroxyethyl cellulose and methyl cellulose.
4. The eye mask essence according to claim 2, wherein the preservative is selected from one or more of phenoxyethanol, ethylhexyl glycerol, chlorphenicol, methylparaben, p-hydroxyacetophenone, 1, 2-hexanediol.
5. A method for preparing the eye mask essence according to any one of claims 1 to 4, comprising the steps of:
(1) Mixing deionized water, polyalcohol, thickener, sodium hyaluronate and dipotassium glycyrrhizinate, stirring, heating, homogenizing, dispersing uniformly to obtain a mixture 1, and cooling for later use;
(2) Mixing inula flower extract, nicotinamide, acetylglucosamine, hydroxyethyl piperazine ethane sulfonic acid, purslane extract and rhodiola root extract, adding the mixture into the mixture 1 cooled in the step (1), and stirring and uniformly mixing to obtain a mixture 2;
(3) Mixing eight-treasure essence stock solution, pine and red plum composite essence, panthenol, glyceroglucoside, oat beta-glucan and ginseng ferment, adding the mixture into the mixture 2 obtained in the step (2), and stirring and uniformly mixing to obtain a mixture 3;
(4) Adding preservative into the mixture 3 obtained in the step (3), uniformly stirring, and then cooling to normal temperature to obtain the eye mask essence.
6. The process according to claim 5, wherein in step (1), the temperature is raised to 75 to 80 ℃ and then lowered to 40 to 45 ℃.
7. An eye mask is characterized by being prepared by combining the eye mask essence and the eye mask base cloth according to any one of claims 1 to 4.
8. Use of the eye mask concentrate of any one of claims 1-4 in the preparation of an eye care product.
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