CN116035982A - Marine biological activity repair cream - Google Patents

Marine biological activity repair cream Download PDF

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Publication number
CN116035982A
CN116035982A CN202310167875.XA CN202310167875A CN116035982A CN 116035982 A CN116035982 A CN 116035982A CN 202310167875 A CN202310167875 A CN 202310167875A CN 116035982 A CN116035982 A CN 116035982A
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parts
culture filtrate
callus culture
cream
marine
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Inventor
焉保明
李伟
王华丽
张巍巍
高源�
贯云娜
戴晓侠
李振兴
焉宝芬
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SHANDONG DRUG AND FOOD VOCATIONAL COLLEGE
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SHANDONG DRUG AND FOOD VOCATIONAL COLLEGE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365Hydroxycarboxylic acids; Ketocarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30Characterized by the absence of a particular group of ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention relates to the technical field of cosmetics, in particular to marine bioactive repair cream. The marine biological activity repair cream comprises apricot kernel oil, squalane, natural coconut oil extract, shea butter, sea fennel callus culture filtrate, coastal thorn celery callus culture filtrate and grape seed extract, and each 100 parts of marine biological activity repair cream comprises: 10.0-20.0 parts of apricot kernel oil; 7.5-15.0 parts of squalane; 6.0-10.0 parts of natural coconut oil extract; 3.0-6.5 parts of shea butter; sea fennel callus culture filtrate (1.0-5.0 parts); 1.5-5.0 parts of littoral parsley callus culture filtrate; grape seed extract (0.1-0.5). The moisturizing cream can delay cell aging while moisturizing, and has obvious functions of resisting wrinkles, resisting aging, removing freckles, resisting allergy and promoting cell regeneration.

Description

Marine biological activity repair cream
Technical Field
The invention relates to the technical field of cosmetics, in particular to marine bioactive repair cream.
Background
The skin is composed of three major parts, epidermis, dermis and subcutaneous tissue. The epidermis is a portion directly contacting the outside, and is a portion having the deepest relationship with the cosmetics. The epidermis is only 0.05-0.15 mm thick and is made up of overlapping keratinocytes. The epidermis is in turn divided, from the inside of the skin, into a basal layer, a barbed layer, a granular layer and a stratum corneum. The metabolism of the skin is by the stratum corneum cells constantly dividing, with a cycle of about 28 days. The stratum corneum has the functions of keeping moisture and preventing the evaporation of moisture in the skin and the invasion of foreign matters, and the natural moisturizing factors, intercellular lipid and hyaluronic acid in the stratum corneum are greatly reduced, so that a series of problems such as dryness, roughness and desquamation of the skin occur.
With the increase of pollutants in the air in cities and the high-pressure life in urban stadiums, more and more people skin has symptoms of sensitivity, premature senility and the like. The skin care cream is also called face cream, which is the last step of oil and water locking of skin and has remarkable water and moisture preserving effects. The repairing cream contains a certain amount of water, can supplement water for skin, contains a small amount of oil, and can moisten skin. However, the traditional emulsion generally uses chemically synthesized grease, the grease content is unreasonable, the grease is not easy to be absorbed by skin, the effects of removing spots and resisting wrinkles cannot be achieved due to lack of nourishing components, meanwhile, a large amount of artificially synthesized chemical raw materials are added, and the skin is stimulated and injured.
Therefore, in combination with the problems, the marine biological activity repair cream with high safety, warmth, no stimulation and environment friendliness is developed, is used for keeping skin healthy, and has important significance for developing new cosmetics products.
Disclosure of Invention
In view of the above, the invention provides a marine bioactive restoration cream, which has the advantages of simple preparation method, low cost, use of various marine bioactive extracts, and cooperation with other main oil control and moisturizing components, so that each component plays a corresponding role, no preservative is added, no harm is caused to skin, skin health is improved, and the effects of resisting wrinkles and aging are achieved while moisturizing.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a marine bioactive repair cream comprises apricot kernel oil, squalane, natural coconut oil extract, shea butter, fructus Foeniculi callus culture filtrate, littoral radix et caulis Parsley callus culture filtrate, and grape seed extract;
each 100 parts of marine biological activity repair cream comprises: 10.0-20.0 parts of apricot kernel oil; 7.5-15.0 parts of squalane; 6.0-10.0 parts of natural coconut oil extract; 3.0-6.5 parts of shea butter; sea fennel callus culture filtrate (1.0-5.0 parts); 1.5-5.0 parts of littoral parsley callus culture filtrate; grape seed extract (0.1-0.5).
Preferably, the method comprises the steps of,
each 100 parts of marine biological activity repair cream comprises: 10.0-16.0 parts of apricot kernel oil; 7.5-10.0 parts of squalane; 6.0-9.5 parts of natural coconut oil extract; 3.0-5.5 parts of shea butter; sea fennel callus culture filtrate (1.0-3.5); 1.5-3.5 parts of littoral parsley callus culture filtrate; grape seed extract (0.1-0.5).
More preferably, the process is carried out,
each 100 parts of marine biological activity repair cream comprises: 12.0-13.5 parts of apricot kernel oil; squalane (7.5-8.5); 8.5-9.5 parts of natural coconut oil extract; 4.5-5.5 parts of shea butter; sea fennel callus culture filtrate (2.5-3.0); 2.5-3.0 parts of littoral parsley callus culture filtrate; grape seed extract (0.2-0.3).
Most preferably, the first and second regions are,
each 100 parts of marine biological activity repair cream comprises: 13.5 parts of apricot kernel oil; 8.5 parts of squalane; 9.5 parts of natural coconut oil extract; 4.5 parts of shea butter; 2.5 parts of sea fennel callus culture filtrate; 2.5 parts of a littoral parsley callus culture filtrate; grape seed extract 0.2 parts.
Apricot kernel oil is high repairability vegetable oil, is extracted from apricot kernels by a cold pressing method, contains abundant mineral substances, GLA and vitamins A, B1, B2, B6 and C, has a strong moisturizing effect, has the functions of helping to tighten and soften skin, and can enable tired skin to recover vitality. Is suitable for mature, dry, desquamated and allergic skin, and is also suitable for skin color yellowish-brown and allergic skin. Apricot kernel oil belongs to soft grease, has fresh and cool air quality, and can generate fresh and fluffy foam.
Squalane is obtained by extracting squalene from olive oil and then hydrogenating the extracted squalene, and is also called plant squalane. Squalane is a component existing in skin, so that the skin care product is very warm and insensitive, has very good skin affinity and permeability, can be highly compatible with sebum secreted by the skin, forms a layer of breathable protective film on the surface layer of the skin, and has the effects of moisturizing and moisturizing. It also can penetrate into skin, supplement cell lipid, promote repair of aged and damaged cells, enhance skin regeneration, and maintain skin elasticity and plumpness.
The natural coconut oil extract is natural substance extracted from coconut, and can be used for mixing and emulsifying oil phase and water phase in cosmetic component to replace chemically synthesized emulsifier, with low irritation to skin and stable performance. The natural coconut oil extract is added into the cosmetics, which not only can play the role of an emulsifier, but also can play the role of whitening and moisturizing.
The extraction of the shea butter is derived from shea butter, the shea butter is a plant with magic maintenance effect, and the shea butter is purely natural green plant source solid grease, can promote the regeneration of epidermal cells and endow the skin with nutrition. The Shea butter has the advantages that various indexes of the oil secreted by the Shea butter and the sebum of the human body are closest, rich non-modeling components are contained, the oil is easy to be absorbed by the human body, not only can the dryness and cracking be prevented, but also the natural elasticity of the skin can be further recovered and maintained, and the oil has good deep moisturizing effect.
Sea fennel callus culture filtrate: the sea fennel has antioxidant effect and is a seaweed extract known as sea lotus seed, convolvulus arvensis or sea taro, and the edible seaweed rich in minerals grows on the rock along the coast of the Mediterranean sea, and draws nutrients from sea fog or sea tide to sustain life. The seaweed callus culture filtrate has the effects of brightening, tightening, anti-aging, omnibearing protection, updating and brightening. It can prevent water loss in skin, and has lipopeptide component to moisten skin, moisten dry skin, smooth young lines and muscle lines, deep into skin lining, strong adaptability, induction of various human growth factors, activate epidermal cells and fibroblasts, and improve skin aging.
The culture filtrate of the littoral parsley callus has the effects of compacting, promoting epidermis update, strengthening dermis-epidermis connection layer, dermis filling and skin moisturizing. New keratinocytes capable of proliferating from the basal layer, stimulating proliferation of the keratinocytes; the skin is brighter and shinier by stimulating the proliferation and differentiation of cells; can stimulate heparin binding epidermal growth factor synthesis; promote new synthesis of macromolecules in the epidermis dermis junction layer, basal layer and upper epidermis layer. The culture filtrate of the littoral parsley callus is rich in flavonoids, amino acids and saccharides, and can be used for anti-edema, analgesic and anti-inflammatory.
The grape seed extract has effects of scavenging free radicals, resisting oxidation and activating cells, and can be used for long-term moisturizing. The skin care product contains abundant vitamin E components, and can make skin more elastic. The grape seed extract also contains rich antioxidant substances, so that the skin is firmer and healthier, the cells of the skin are more active, and the effect of delaying senescence is very strong. The grape seed extract also contains rich polyphenol substances and procyanidins, and the components can reduce the damage of free radicals to our skin, prevent the influence of ultraviolet rays on the skin and play a good role in protecting the skin. The skin care composition has the advantages of improving skin immunity, protecting collagen in skin from being influenced by oxidization, reducing external influence on skin, and improving self-repairing capability.
The marine biological activity restoration cream also contains natural citric acid for regulating the pH value, so that the pH value of the marine biological activity restoration cream is 6.0-6.5.
The natural citric acid is a natural fruit acid extracted from fruits such as lemon, orange, pineapple, etc., and can be used as pH regulator of repair cream instead of chemically synthesized strong acid in cosmetics. The citric acid as a natural fruit acid can improve the natural moisturizing ability of skin, so that the skin maintains a certain humidity, and the generation of fine wrinkles is reduced. Can also accelerate cutin update, promote melanin in skin to drop, shrink pores, dissolve blackheads, make skin present soft and young state, and improve rough inelastic aged skin. Because the secretion of sebaceous glands can be improved after the cutin is softened, the effect of eliminating facial sores can be achieved.
The preparation method of the product comprises the following steps:
(1) The oil phase component is prepared by mixing apricot kernel oil, squalane, shea butter and grape seed extract respectively.
(2) The water phase component is prepared by uniformly mixing the littoral callus culture filtrate and the fennel callus culture filtrate.
(3) Weighing natural coconut oil extract, heating for dissolving, adding into water phase component, and stirring.
(4) Heating the water phase obtained in the step 3 to 50-60 ℃, slowly adding the water phase into the oil phase in the step 1, and emulsifying uniformly.
(5) And (3) using natural citric acid as an acid-base regulator, regulating the pH value of the whole component to 6.0-6.5, and continuously adding water until the amount is enough.
The invention has the following advantages:
1. the marine bioactive materials and the natural plant essence exert synergistic effect, so that the components exert maximum effect, are all natural components, and do not contain chemicals and do not cause harm to skin.
2. The moisturizing effect of the repair cream is obvious, and experiments prove that the product has obvious reduction of the percutaneous water loss rate after use, thus indicating that the product has better moisturizing effect.
3. The moisturizing cream can delay cell aging while moisturizing, and has obvious functions of resisting wrinkles, resisting aging, removing freckles, resisting allergy and promoting cell regeneration. The composition of the components is different, and the effects of resisting wrinkles, resisting aging, removing freckles and preserving moisture are also different.
4. The product is suitable for people with various skin types, has high cost performance and is environment-friendly.
Detailed Description
The invention is further illustrated by the following examples:
example 1:
apricot kernel oil 16.0g squalane 10.0g natural coconut oil extract 6.0g shea butter 3.0g
Sea fennel callus culture filtrate 3.5g littoral callus culture filtrate 3.5g
Grape seed extract 0.5g
Natural citric acid was adjusted to pH 6.0 and purified water was added to 100g.
The preparation method comprises the following steps:
(1) Mixing apricot kernel oil, squalane, shea butter and grape seed extract to obtain oil phase component;
(2) Uniformly mixing the littoral callus culture filtrate and the fennel callus culture filtrate to obtain a water phase component;
(3) Weighing natural coconut oil extract, heating for dissolving, adding into water phase component, and stirring;
(4) Heating the water phase component in the step (3) to 50-60 ℃, slowly adding the water phase component into the oil phase component in the step (1), and emulsifying uniformly;
(5) Using natural citric acid as an acid-base regulator, regulating the pH value of the whole component to 6.0, and continuously adding purified water to 100g to obtain the natural citric acid;
(6) And (5) checking and split charging.
Example 2:
apricot kernel oil 10.0g squalane 7.5. 7.5 g Natural coconut oil extract 9.5g Shea butter 5.5g
Sea fennel callus culture filtrate 1.0g littoral callus culture filtrate 3.5g grape seed extract 0.5g
Natural citric acid was adjusted to pH 6.0 and purified water was added to 100g.
The preparation method is the same as in example 1.
Example 3:
apricot kernel oil 13.0g squalane 7.5. 7.5 g Natural coconut oil extract 6.5g Shea butter 3.5g
Sea fennel callus culture filtrate 3.5g littoral callus culture filtrate 1.5g grape seed extract 0.1g
Natural citric acid was adjusted to pH 6.0 and purified water was added to 100g.
The preparation method is the same as in example 1.
Example 4:
apricot kernel oil 12.0g squalane 7.5. 7.5 g Natural coconut oil extract 8.5g Shea butter 5.5g
Sea fennel callus culture filtrate 3.0g littoral callus culture filtrate 3.0g grape seed extract 0.3g
Natural citric acid was adjusted to pH 6.0 and purified water was added to 100g.
The preparation method is the same as in example 1.
Example 5:
apricot kernel oil 13.5g squalane 8.5. 8.5g Natural coconut oil extract 9.5g Shea butter 4.5g
Sea fennel callus culture filtrate 2.5g littoral callus culture filtrate 2.5g grape seed extract 0.2g
Natural citric acid was adjusted to pH 6.0 and purified water was added to 100g.
The preparation method is the same as in example 1.
Test sample: the marine active repair creams obtained in examples 1, 2, 3, 4, 5 were labeled as sample 1, 2, 3, 4, 5, respectively.
The commercial normal repair cream is labeled as control 1.
The samples prepared in examples 1 to 5 were compared with placebo, which is a commercially available common product, using a VISA tester, CK tester, etc., and skin data were collected by taking a repair cream of Henlana Lvbao bottle, which is a commercially available repair cream, which is purported to contain a littoral callus culture filtrate, a maritime callus culture filtrate, and a placebo (13.5 g of apricot kernel oil, 8.5g of squalane, 9.5g of natural coconut oil extract, and 4.5g of shea butter, and no addition of a maritime callus culture filtrate, a littoral callus culture filtrate, and a grape seed extract).
The testing method comprises the following steps:
(1) Testing environmental conditions
Testing ambient temperature: 20-22 ℃, humidity: 40% -60% and real-time dynamic monitoring is performed.
(2) Number of volunteers
Active volunteers 56.
(3) Volunteer condition
The ages range from 25 years to 45 years, 28 men and 28 women, and the face has skin problems such as color spots, wrinkles, darkness, sensitivity and the like. In the daily living environment, no direct insolation exists, and no medicine is used in the previous month.
Operating procedure
The compliance of volunteers is checked firstly, then the volunteers are divided into 7 groups randomly and averagely, 4 men and 4 women are used for each group randomly, a marine biological activity repair cream is used for each group, after the skin of the face is cleaned by using standard facial cleanser in a nursing room for the first day and is wiped dry, skin data (erythema index, speckle index, wrinkle index, percutaneous water loss rate, anaphylaxis rate and the like) are sequentially collected by using VISA and CK for more than 20 minutes after constant temperature and constant humidity waiting, and two times of data are collected for 30 minutes and 60 minutes after the collection, wherein the three times of data are used as initial data.
And then the distributed essence is used as required after the face is cleaned in the morning and evening every day, the continuous use is carried out for 8 weeks, a batch of data is collected every 4 days, test repair cream is dispensed, and the data collection method is the same as the above, and the time is afternoon. The data were collected as final data after 8 weeks of continuous use, and the experimental results are shown in table 1:
TABLE 1
Test sample Placebo Comparative example Example 1 Example 2 Example 3 Example 4 Example 5
Mean change in erythema index Raised by 3.31% Reduced by 25.23% Reduced by 32.16% Reduced by 25.71% Reduced by 25.34% Reduced by 27.63% Reduced by 32.42%
Average change value of speckle index Raised by 0.72% Reduced by 1.32% Reduced by 29.3% Reduced by 18.2% Reduced by 19.8% Reduced by 27.6% Reduced by 24.3%
Average change value of wrinkle index Reduced by 0.25% Reduced by 4.01% Reduced by 41.9% Reduced by 41.1% Reduced by 42.3% Reduced by 50.3% Reduced by 53.7%
Average change value of percutaneous water loss rate Reduced by 3.07% Reduced by 22.80% Reduced by 54.31% Reduced by 45.1% Reduced by 49.9% Reduced by 53.44% Reduced by 48.43%
Rate of allergy 12.4% 0 0 0 0 0 0
As can be seen from Table 1, the volunteers using the placebo group had significantly increased skin erythema index (representing inflammation) and a list of macroscopic allergic phenomena, while the commercial products using the pimpinella callus culture filtrate, and the volunteers of examples 1-5 had significantly reduced skin erythema index, and none of them had allergy, indicating that the commercial products containing the pimpinella callus culture filtrate, and examples 1-5 had significantly restored allergic skin functions.
From the point of view of the change of the spot index representing the spot removal effect, the commercial products containing the littoral callus culture filtrate and the fennel callus culture filtrate have no such effect, while the spot index of examples 1 to 5 is significantly reduced, indicating that examples 1 to 5 all have a significant spot removal effect.
From the change of wrinkle index representing wrinkle removing effect, the commercial products containing the littoral callus culture filtrate and the fennel callus culture filtrate have no such function, while the wrinkle index of examples 1-5 is obviously reduced, which means that examples 1-5 have obvious wrinkle removing effect, especially examples 4 and 5, and the wrinkle index is reduced by more than 50% on average.
From the point of view of the change in the rate of percutaneous water loss representing the effect of skin moisturizing ability, volunteers using placebo without addition of the pimpinella tissue culture filtrate, the change in the rate of percutaneous water loss of the skin was small, whereas the commercial products containing the pimpinella tissue culture filtrate, the pimpinella tissue culture filtrate and examples 1-5 had a significant decrease in the rate of percutaneous water loss, indicating that the commercial products containing the pimpinella tissue culture filtrate, the pimpinella tissue culture filtrate and examples 1-5 had a significant effect of enhancing skin moisturizing ability.
In summary, the commercial products containing the sea fennel callus culture filtrate and the coastal thorny celery callus culture filtrate have obvious effects on the aspects of anti-allergic repair and moisturizing, while examples 1-5 have obvious effects on the aspects of anti-allergic repair and moisturizing, have obvious effects of removing spots, removing wrinkles and the like, and can meet the requirements on the effect nursing of sensitive skin.
And examples 4 and 5 have a good effect of reducing the erythema index, a good effect of reducing the speckle index and a good effect of reducing the percutaneous water loss rate, and especially a good effect of reducing the wrinkle index, namely, when each 100 parts of marine restoration cream comprises the following components: 12.0 to 13.5 parts of apricot kernel oil, 7.5 to 8.5 parts of squalane, 8.5 to 9.5 parts of natural coconut oil extract, 4.5 to 5.5 parts of shea butter, 2.5 to 3.0 parts of sea fennel callus culture filtrate, 2.5 to 3.0 parts of coastal thorny callus culture filtrate and 0.2 to 0.3 part of grape seed extract, and the prepared marine biological activity repair cream has the best effects of antiallergic, freckle removing, wrinkle removing, repair and the like.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (8)

1. The marine biological activity repair cream is characterized by comprising apricot kernel oil, squalane, natural coconut oil extract, shea butter, fennel callus culture filtrate, coastal thorny callus culture filtrate and grape seed extract, wherein the pH of the marine biological activity repair cream is 6.0-6.5.
2. The marine bioactive restoration cream as recited in claim 1, wherein each 100 parts of the marine bioactive restoration cream comprises: 10.0-20.0 parts of apricot kernel oil; 7.5-15.0 parts of squalane; 6.0-10.0 parts of natural coconut oil extract; 3.0-6.5 parts of shea butter; 1.0-5.0 parts of sea fennel callus culture filtrate; 1.5-5.0 parts of littoral parsley callus culture filtrate; 0.1-0.5 part of grape seed extract.
3. The marine bioactive restoration cream as recited in claim 1, wherein each 100 parts of the marine bioactive restoration cream comprises: 10.0-16.0 parts of apricot kernel oil; 7.5-10.0 parts of squalane; 6.0-9.5 parts of natural coconut oil extract; 3.0-5.5 parts of shea butter; 1.0-3.5 parts of sea fennel callus culture filtrate; 1.5-3.5 parts of littoral parsley callus culture filtrate; 0.1-0.5 part of grape seed extract.
4. The marine bioactive restoration cream as recited in claim 1, wherein each 100 parts of the marine bioactive restoration cream comprises: 12.0-13.5 parts of apricot kernel oil; 7.5-8.5 parts of squalane; 8.5-9.5 parts of natural coconut oil extract; 4.5-5.5 parts of shea butter; 2.5-3.0 parts of sea fennel callus culture filtrate; 2.5-3.0 parts of littoral parsley callus culture filtrate; 0.2-0.3 parts of grape seed extract.
5. The marine bioactive restoration cream as recited in claim 1, wherein each 100 parts of the marine bioactive restoration cream comprises: 13.5 parts of apricot kernel oil; 8.5 parts of squalane; 9.5 parts of natural coconut oil extract; 4.5 parts of shea butter; 2.5 parts of sea fennel callus culture filtrate; 2.5 parts of a littoral parsley callus culture filtrate; grape seed extract 0.2 parts.
6. Marine bioactive repair cream according to any of claims 1-5, further comprising natural citric acid.
7. The method for preparing the marine bioactive restoration cream as set forth in claim 1, comprising the steps of:
(1) Preparing oil phase components by mixing apricot kernel oil, squalane, shea butter and grape seed extract;
(2) Preparing water phase component, namely uniformly mixing the littoral guava callus culture filtrate and the fennel callus culture filtrate;
(3) Weighing natural coconut oil extract, heating for dissolving, adding into water phase component, and stirring;
(4) Heating the water phase obtained in the step (3) to 50-60 ℃, slowly adding the water phase into the oil phase in the step (1), and emulsifying uniformly;
(5) And (3) using natural citric acid as an acid-base regulator, regulating the pH value of the whole component to 6.0-6.5, and continuously adding water until the amount is enough.
8. Use of a marine bioactive repair cream as claimed in any one of claims 1 to 6 in the manufacture of a cosmetic product for moisturizing, anti-allergic repair, freckle removal or wrinkle removal.
CN202310167875.XA 2023-02-27 2023-02-27 Marine biological activity repair cream Pending CN116035982A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117205130A (en) * 2023-11-08 2023-12-12 北京尧景基因技术有限公司 Extraction method of littoral callus vesicles and application of littoral callus vesicles in preparation of antioxidant or anti-inflammatory skin products

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117205130A (en) * 2023-11-08 2023-12-12 北京尧景基因技术有限公司 Extraction method of littoral callus vesicles and application of littoral callus vesicles in preparation of antioxidant or anti-inflammatory skin products
CN117205130B (en) * 2023-11-08 2024-02-02 北京尧景基因技术有限公司 Extraction method of littoral callus vesicles and application of littoral callus vesicles in preparation of antioxidant or anti-inflammatory skin products

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