CN114146116A - External itching relieving ointment containing red imported fire ants, stings and other ingredients, and preparation method and application thereof - Google Patents

External itching relieving ointment containing red imported fire ants, stings and other ingredients, and preparation method and application thereof Download PDF

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CN114146116A
CN114146116A CN202111547041.9A CN202111547041A CN114146116A CN 114146116 A CN114146116 A CN 114146116A CN 202111547041 A CN202111547041 A CN 202111547041A CN 114146116 A CN114146116 A CN 114146116A
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parts
stirring
vaseline
lanolin
beeswax
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石庆型
吕利华
齐国君
陈洁
陈婷
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Plant Protection Research Institute Guangdong Academy of Agricultural Sciences
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics

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Abstract

The invention discloses an external itching relieving ointment containing red imported fire ant bite sting and a preparation method and application thereof. The composite material comprises the following raw materials in parts by weight: 10-30 parts of diphenhydramine hydrochloride, 310-30 parts of vitamin B, 10-30 parts of menthol, 10-30 parts of camphor, 10-30 parts of borneol, 10-30 parts of eucalyptus oil, 40-50 parts of beeswax, 80-100 parts of lanolin and 1000 parts of vaseline. The external itching relieving ointment for the stings of the solenopsis invicta has the effects of sterilizing, relieving itching, clearing heat, removing dampness, dispelling wind and removing toxicity, has the effects of relieving pain and itching after being smeared on the affected parts of the stings of the solenopsis invicta for 1-2 minutes, can relieve itching for a long time, and avoids inflammation caused by skin damage after scratching. Meanwhile, the external itching relieving ointment for the stings of the solenopsis invicta can form a layer of protective film on the surface of the skin, prevent and treat the propagation of pathogenic bacteria and achieve the effects of sterilization and itching relieving.

Description

External itching relieving ointment containing red imported fire ants, stings and other ingredients, and preparation method and application thereof
The technical field is as follows:
the invention belongs to the field of daily-use general goods, and particularly relates to an external itching relieving ointment containing red imported fire ant bite sting and a preparation method and application thereof.
Background art:
the red fire ants (Solenopsis invicta Buren) are native to Brazil and Argentina baralana river basin in south America, belong to the Antrodia family of hymenoptera, are one of the most important 100 invasive organisms in the world, and pose serious threats to agricultural ecological environment, public safety and life safety of people. The red fire ants are extremely aggressive, attack humans after being disturbed, and also produce extremely strong group attacks, injecting venom into the skin of the victim by stinging and biting. The stinged part has continuous burning pain, local skin forms erythema, blister and hard swelling, and is accompanied with extremely strong skin itch, and bacteria secondary infection is easy to appear after the blister is broken after scratching. At present, an itching relieving product aiming at stings of red imported fire ants is lacked in the market, and itching relieving is mainly carried out by using cooling oil and balm products at the present stage, wherein the main raw materials of the product are camphor, borneol and mint, the raw material oil has the effects of relieving swelling and pain, dispelling wind and dissipating heat, and takes effect quickly to a certain extent.
Disclosure of Invention
The invention aims to provide an external itching relieving ointment for treating the stings of the solenopsis invicta, which has the advantages of quick itching relieving and long time effectiveness.
In order to achieve the above object, the present invention adopts the following technical solutions.
An external itching relieving ointment for red imported fire ant bite stings comprises the following raw materials in parts by weight: 10-30 parts of diphenhydramine hydrochloride, 310-30 parts of vitamin B, 10-30 parts of menthol, 10-30 parts of camphor, 10-30 parts of borneol, 10-30 parts of eucalyptus oil, 40-50 parts of beeswax, 80-100 parts of lanolin and 1000 parts of vaseline.
Preferably, the external itching relieving ointment for the stings of the red imported fire ants comprises the following raw materials in parts by weight: 20 parts of diphenhydramine hydrochloride, 320 parts of vitamin B, 20 parts of menthol, 20 parts of camphor, 20 parts of borneol, 20 parts of eucalyptus oil, 40 parts of beeswax, 80 parts of lanolin and 1000 parts of vaseline.
The second purpose of the invention is to provide a preparation method of the external itching relieving ointment for the stings of the red imported fire ants, which comprises the following steps:
A. grinding diphenhydramine hydrochloride, camphor, menthol and borneol respectively and sieving;
B. mixing Camphora and Mentholum, melting them together, adding oleum Eucalypti, and mixing to obtain aromatic oil mixture.
C. Mixing beeswax, vaseline and lanolin, heating to dissolve them, and stirring;
D. adding the aromatic oil mixed solution into the hot mixed solution of the beeswax, the vaseline and the lanolin, stirring and mixing uniformly, then cooling to 45-55 ℃, adding diphenhydramine hydrochloride, vitamin B3 and borneol powder, stirring and mixing uniformly, stopping heating, cooling to 30-35 ℃, stopping stirring, and cooling to room temperature.
Preferably, the sieve is a No. 6 sieve (100 mesh).
Preferably, the heating is water bath heating to 80 ℃.
Preferably, the step D is: adding the aromatic oil mixed solution into the hot mixed solution of the beeswax, the vaseline and the lanolin, stirring for 30min at the stirring speed of 30-40 r/min, then cooling to 45-55 ℃, adding diphenhydramine hydrochloride, vitamin B3 and borneol powder, stirring for 30min at the stirring speed of 15-25 r/min, stopping heating, cooling to 30-35 ℃, stopping stirring, and cooling to room temperature.
The pharmacological actions of the raw materials are as follows:
diphenhydramine hydrochloride: has antihistaminic H1 receptor effect, has strong inhibitory effect on central nerve, and is also effective on skin mucosa allergy such as urticaria, angioneurotic edema, allergic rhinitis, other skin pruritus, anal pruritus, vulval pruritus, pruritus due to drug eruption or jaundice, insect bite and contact dermatitis. Vitamin B3 can inhibit the formation of skin melanin, prevent pachylosis, and is beneficial to the recovery of injured cells or skin, and has important effect on maintaining the integrity of normal tissues, especially skin, digestive tract, and nervous system. Menthol: has pungent taste and cool nature, and can be used for cooling skin or mucosa to relieve discomfort and pain. Camphor: has pungent taste and warm nature, and has effects of dredging orifices, benefiting qi stagnation, removing filth, killing parasites, relieving itching, and relieving swelling and pain. Borneol: has pungent, bitter and slightly cold taste, is suitable for heart, liver and lung channels, has faint scent, and has effects of clearing heat, removing toxic substances, relieving swelling and clearing pathogenic fire. Eucalyptus oil: it is pungent, bitter and neutral in nature, and can be used for treating skin pruritus and neuralgia. Beeswax: sweet in flavor, slightly warm in nature, with the actions of removing toxicity, healing wound, promoting granulation and alleviating pain. Lanolin: can be rapidly absorbed by mucosa and skin, and has the advantages of good adhesion, stable property, water absorption, and no rancidity. Vaseline: keep skin tissue moist, reduce air contact and bacterial infection, make the surface of a wound keep the state of higher self-repair ability, difficult to leave the scar.
The traditional Chinese medicines and the western medicines are combined to play the effects of sterilizing, relieving itching, clearing heat, eliminating dampness, reducing swelling, resolving masses, dispelling wind and removing toxicity, and can alleviate the skin inflammatory reaction of patients with burn, scald and itching.
The invention also provides a using method of the external itching relieving ointment for the stings of the red fire ants, and particularly a small amount of the external itching relieving ointment for the stings of the red fire ants is smeared at the stings of the red fire ants for 2-3 times a day.
The invention also provides application of the external itching relieving ointment for the red imported fire ant bite sting in preparing a medicine for treating the red imported fire ant bite sting.
The invention has the beneficial technical effects that:
the external itching relieving ointment for the stings of the solenopsis invicta has the effects of sterilizing, relieving itching, clearing heat, removing dampness, dispelling wind and removing toxicity, has the effects of relieving pain and itching after being smeared on the affected parts of the stings of the solenopsis invicta for 1-2 minutes, can relieve itching for a long time, and avoids inflammation caused by skin damage after scratching. Meanwhile, the external itching relieving ointment for the stings of the solenopsis invicta can form a layer of protective film on the surface of the skin, prevent and treat the propagation of pathogenic bacteria and achieve the effects of sterilization and itching relieving.
Detailed Description
The following examples are further intended to illustrate the technical solutions of the present invention in detail, but not to limit the scope of the present invention.
The formulations of the examples of the invention are shown in table 1.
TABLE 1 formulation of examples of the invention (parts by weight)
Diphenhydramine hydrochloride Vitamin B3 Menthol crystal Camphor Borneol (borneol) Eucalyptus oil Beeswax (Cera flava) Lanolin Vaseline
Example 1 20 20 20 20 20 20 40 80 1000
Example 2 10 10 10 10 10 10 40 80 1000
Example 3 30 30 30 30 30 30 50 100 1000
Practice ofExample 4 0 20 20 20 20 20 40 80 1000
Example 5 20 0 0 0 0 0 40 80 1000
Example 1
An external itching relieving ointment containing red imported fire ant bite sting comprises the following raw materials in parts by weight: 20 parts of diphenhydramine hydrochloride, 320 parts of vitamin B, 20 parts of menthol, 20 parts of camphor, 20 parts of borneol, 20 parts of eucalyptus oil, 40 parts of beeswax, 80 parts of lanolin and 1000 parts of vaseline.
The invention also provides a preparation method of the external itching relieving ointment containing the red imported fire ant bite sting, which comprises the following steps:
(1) respectively grinding diphenhydramine hydrochloride, camphor, menthol and borneol, and sieving with No. 6 sieve (100 mesh).
(2) Mixing Camphora and Mentholum, melting them together, adding oleum Eucalypti, and mixing to obtain aromatic oil mixture.
(3) Mixing beeswax, vaseline and lanolin, heating in water bath to 80 deg.C to dissolve them, and stirring.
(4) And respectively adding the aromatic oil mixed solution into the hot mixed solution of the beeswax, the vaseline and the lanolin, and stirring for 30min at the stirring speed of 30-40 r/min. And then cooling to 45-55 ℃, adding diphenhydramine hydrochloride, vitamin B3 and borneol powder, stirring for 30min at the stirring speed of 15-25 r/min, stopping heating, cooling to 30-35 ℃, stopping stirring, bottling and sealing after cooling to room temperature.
Example 2
An external itching relieving ointment containing red imported fire ant bite sting comprises the following raw materials in parts by weight: 10 parts of diphenhydramine hydrochloride, 310 parts of vitamin B, 10 parts of menthol, 10 parts of camphor, 10 parts of borneol, 10 parts of eucalyptus oil, 40 parts of beeswax, 80 parts of lanolin and 1000 parts of vaseline.
The invention also provides a preparation method of the external itching relieving ointment containing the red imported fire ant bite sting, which comprises the following steps:
(1) respectively grinding diphenhydramine hydrochloride, camphor, menthol and borneol, and sieving with No. 6 sieve (100 mesh).
(2) Mixing Camphora and Mentholum, melting them together, adding oleum Eucalypti, and mixing to obtain aromatic oil mixture.
(3) Mixing beeswax, vaseline and lanolin, heating in water bath to 80 deg.C to dissolve them, and stirring.
(4) And respectively adding the aromatic oil mixed solution into the hot mixed solution of the beeswax, the vaseline and the lanolin, and stirring for 30min at the stirring speed of 30-40 r/min. And then cooling to 45-55 ℃, adding diphenhydramine hydrochloride, vitamin B3 and borneol powder, stirring for 30min at the stirring speed of 15-25 r/min, stopping heating, cooling to 30-35 ℃, stopping stirring, bottling and sealing after cooling to room temperature.
Example 3
An external itching relieving ointment containing red imported fire ant bite sting comprises the following raw materials in parts by weight: 30 parts of diphenhydramine hydrochloride, 330 parts of vitamin B, 30 parts of menthol, 30 parts of camphor, 30 parts of borneol, 30 parts of eucalyptus oil, 50 parts of beeswax, 100 parts of lanolin and 1000 parts of vaseline.
The invention also provides a preparation method of the external itching relieving ointment containing the red imported fire ant bite sting, which comprises the following steps:
(1) respectively grinding diphenhydramine hydrochloride, camphor, menthol and borneol, and sieving with No. 6 sieve (100 mesh).
(2) Mixing Camphora and Mentholum, melting them together, adding oleum Eucalypti, and mixing to obtain aromatic oil mixture.
(3) Mixing beeswax, vaseline and lanolin, heating in water bath to 80 deg.C to dissolve them, and stirring.
(4) And respectively adding the aromatic oil mixed solution into the hot mixed solution of the beeswax, the vaseline and the lanolin, and stirring for 30min at the stirring speed of 30-40 r/min. And then cooling to 45-55 ℃, adding diphenhydramine hydrochloride, vitamin B3 and borneol powder, stirring for 30min at the stirring speed of 15-25 r/min, stopping heating, cooling to 30-35 ℃, stopping stirring, bottling and sealing after cooling to room temperature.
Example 4
An external itching relieving ointment containing red imported fire ant bite sting comprises the following raw materials in parts by weight: 320 parts of vitamin B, 20 parts of menthol, 20 parts of camphor, 20 parts of borneol, 20 parts of eucalyptus oil, 40 parts of beeswax, 80 parts of lanolin and 1000 parts of vaseline.
The invention also provides a preparation method of the external itching relieving ointment containing the red imported fire ant bite sting, which comprises the following steps:
(1) respectively grinding vitamin B3, Camphora, Mentholum and Borneolum Syntheticum, and sieving with No. 6 sieve (100 mesh).
(2) Mixing Camphora and Mentholum, melting them together, adding oleum Eucalypti, and mixing to obtain aromatic oil mixture.
(3) Mixing beeswax, vaseline and lanolin, heating in water bath to 80 ℃, dissolving the beeswax, the vaseline and the lanolin, and stirring and uniformly mixing the beeswax, the vaseline and the lanolin at the stirring speed of 30-40 r/min.
(4) And respectively adding the aromatic oil mixed solution into the hot mixed solution of the beeswax, the vaseline and the lanolin, and stirring for 30min at the stirring speed of 30-40 r/min. And then cooling to 45-55 ℃, adding vitamin B3 and borneol powder, stirring for 30min at the stirring speed of 15-25 r/min, stopping heating, cooling to 30-35 ℃, stopping stirring, bottling and sealing after cooling to room temperature.
Example 5
An external itching relieving ointment containing red imported fire ant bite sting comprises the following raw materials in parts by weight: 20 parts of diphenhydramine hydrochloride, 40 parts of beeswax, 80 parts of lanolin and 1000 parts of vaseline.
The invention also provides a preparation method of the external itching relieving ointment containing the red imported fire ant bite sting, which comprises the following steps:
(1) diphenhydramine hydrochloride is ground and sieved by a No. 6 sieve (100 meshes).
(2) Mixing beeswax, vaseline and lanolin, heating to 80 ℃, dissolving the beeswax, vaseline and lanolin, and stirring uniformly at a stirring speed of 30-40 r/min.
(3) And (3) cooling to 45-55 ℃, adding diphenhydramine hydrochloride powder, stirring for 30min at the stirring speed of 15-25 r/min, stopping heating, cooling to 30-35 ℃, stopping stirring, bottling and sealing when cooling to room temperature.
Clinical data
(1) The inventor carries out clinical observation and treatment on the sufferers who stings and itch from the red imported fire ants through a plurality of times of clinical verification.
(2) Method of treatment
The external itching relieving ointment for the red imported fire ant bite sting is smeared on the red imported fire ant bite sting for 2-3 times a day.
(3) Matters of attention
Avoiding contact with the eye and other mucosal parts. It is contraindicated when its properties change, and it is sensitive to this herb, so it is contraindicated when the affected part has ulcerated and suppurative. It is forbidden for infants, pregnant women and lactating women.
In order to investigate the curative effect of the external itching relieving ointment for the red imported fire ant stings, the tested persons are randomly selected in different red imported fire ant occurrence areas in Guangdong province, the external itching relieving ointment for the red imported fire ant stings is distributed to the tested persons for testing, the using method and the applying dosage of the ointment are guided, and then the drug effect return visit investigation is carried out through a telephone. Inquiring and recording the relief conditions of the tested patients such as pruritus, red swelling, pustule and the like. The results are shown in Table 2
TABLE 2 investigation of the efficacy of antipruritic ointments formulated in different examples on the bite sting of red fire ants [ n (%) ]
Figure BDA0003416049160000081
As shown in test examples 1-5, the itching relieving ointment for red imported fire ant bite disclosed by the invention can quickly relieve itching and pain, can relieve itching for a long time, and can effectively relieve symptoms such as skin red swelling and pustule.
The embodiments described above are described to facilitate an understanding and use of the invention by those skilled in the art. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above embodiments, and those skilled in the art should make improvements and modifications within the scope of the present invention based on the disclosure of the present invention.

Claims (7)

1. An external itching relieving ointment containing red imported fire ant bite sting is characterized by comprising the following raw materials in parts by weight: 10-30 parts of diphenhydramine hydrochloride, 310-30 parts of vitamin B, 10-30 parts of menthol, 10-30 parts of camphor, 10-30 parts of borneol, 10-30 parts of eucalyptus oil, 40-50 parts of beeswax, 80-100 parts of lanolin and 1000 parts of vaseline.
2. The external itching relieving ointment for stings of solenopsis invicta of claim 1, which is characterized by comprising the following raw materials in parts by weight: 20 parts of diphenhydramine hydrochloride, 320 parts of vitamin B, 20 parts of menthol, 20 parts of camphor, 20 parts of borneol, 20 parts of eucalyptus oil, 40 parts of beeswax, 80 parts of lanolin and 1000 parts of vaseline.
3. A preparation method of an external itching relieving ointment containing red imported fire ant bite sting is characterized by comprising the following steps:
A. grinding diphenhydramine hydrochloride, camphor, menthol and borneol respectively and sieving;
B. mixing Camphora and Mentholum, melting them together, adding oleum Eucalypti, and mixing to obtain aromatic oil mixture.
C. Mixing beeswax, vaseline and lanolin, heating to dissolve them, and stirring;
D. adding the aromatic oil mixed solution into the hot mixed solution of the beeswax, the vaseline and the lanolin, stirring and mixing uniformly, then cooling to 45-55 ℃, adding diphenhydramine hydrochloride, vitamin B3 and borneol powder, stirring and mixing uniformly, stopping heating, cooling to 30-35 ℃, stopping stirring, and cooling to room temperature.
4. The method of claim 3, wherein the screen is a No. 6 screen.
5. The method of claim 3, wherein the heating is carried out in a water bath to 80 ℃.
6. The method according to claim 3, wherein the step D comprises: adding the aromatic oil mixed solution into the hot mixed solution of the beeswax, the vaseline and the lanolin, stirring for 30min at the stirring speed of 30-40 r/min, then cooling to 45-55 ℃, adding diphenhydramine hydrochloride, vitamin B3 and borneol powder, stirring for 30min at the stirring speed of 15-25 r/min, stopping heating, cooling to 30-35 ℃, stopping stirring, and cooling to room temperature.
7. Use of the topical antipruritic ointment of solenopsis invicta bite sting according to claim 1 or 2 in the manufacture of a medicament for the treatment of solenopsis invicta bite sting.
CN202111547041.9A 2021-12-16 2021-12-16 External itching relieving ointment containing red imported fire ants, stings and other ingredients, and preparation method and application thereof Pending CN114146116A (en)

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* Cited by examiner, † Cited by third party
Title
朱海英等: "止痒乳膏的制备及应用", 《中国药业》 *

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