CN106511580A - Itching relieving composition and application thereof - Google Patents
Itching relieving composition and application thereof Download PDFInfo
- Publication number
- CN106511580A CN106511580A CN201710007061.4A CN201710007061A CN106511580A CN 106511580 A CN106511580 A CN 106511580A CN 201710007061 A CN201710007061 A CN 201710007061A CN 106511580 A CN106511580 A CN 106511580A
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- itching relieving
- cardiospermum halicacabum
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an itching relieving composition. The itching relieving composition comprises cardiospermum halicacabum extract, herba portulacae extract, lavender essential oil, camphor and borneolum syntheticum. The itching relieving composition has the advantages that the four effective components, namely cardiospermum halicacabum extract, herba portulacae extract, camphor and lavender essential oil, are matched with one another according to specific proportions; accordingly, the itching relieving composition, containing abundant diversified functional components which are blended with one another and cooperate with one another, has antibacterial and anti-inflammation effects and an excellent itching relieving function. The itching relieving composition can be applied to emulsion for treating insect bite, integral formula emulsification systems are excellent, the itching relieving composition is good in compatibility and rheological property and easy to prepare, can be absorbed by skins easily and is practical, applicable and economical, and the like.
Description
Technical field
The present invention relates to medicine, and in particular to a kind of anti-pruritic compositions and its application.
Background technology
Pruitus is dermatitis, eczema, nettle rash, contact dermatitis, prurigo nodularis, xerodermia, superficial mycosis
The modal clinical manifestation of disease of skin such as infection, psoriasis and atopic dermatitis, and it is diabetes, Intrahepatic Cholestasis, chronic
The important clinical manifestation of the systemic diseases such as ephrosis, tumour and AIDS.According to neuro-physiology pathogenesis, pruitus can
It is divided into several different types:Skin source property pruitus is the skin scabies of scytitis, drying and other noxious stimulation inductions
Itch, the C- nerve fibres subunit of sensitization is the specific conduction path of itch signal, such as scabies, nettle rash and bite by mosquitos reaction
The pruitus of induction；Neural pathogenic pruitus is the pruitus of nervous system injury induction；Multiple sclerosis is suffered from
The paroxysmal pruitus that person breaks out；Neurogenic pruitus is relevant with normally functioning nervous system.
The dermatitis that bite by mosquitos causes in insect dermatitis is modal.Mosquito stabs skin by its mouthpart, its saliva
Liquid or venom invade skin, and due to containing various antigenic components in the saliva of mosquito or the leachate of poison gland, these antigens are entering
Allergic reaction can be produced with antibody after entering human body skin and cause inflammation.When serious, indivedual infant local produce bleb, bleeding
The severe reactions such as property necrosis, are summer dermatology common disease diseases.Insect bite dermatitis show as the place of biting occur papule, wheal,
Edematous erythema, blister, papulo-vesicle, petechia ecchymosis etc., middle visible thorn are suck a little, be dispersed in distribution or it is several in groups, can betide
Parts of body, and with it is different degrees of itch, tingling sensation, wherein most commonly seen with pruitus.
Chinese patent application CN105943980A discloses a kind of antipruritic plaster, raw material include kuh-seng, smilax, the tuber of stemona,
Azedarach, sealwort, stream Huang, spot huge legendary turtle, chaulmoogra, hop, corter pseudolaricis, the root of langdu, menthol, acetylsalicylic acid, albolene and oxidation
Zinc.The invention complicated component, complicated process of preparation.
The common medicine for being presently used for pruitus has erythromycin for oral administration, Ciprofloxacin, intramuscular injection penicillin etc., but such anti-
Raw element can reduce the immunity of human body, long with developing immunity to drugs.The antianaphylactic medicine of anti-inflammatory has prednisone, dexamethasone etc. to swash in addition
Plain class medicine, Long-Time Service can produce digestive system ulcer, osteoporosis, affect development, particularly for children, then can produce resistance to
The property of medicine, meanwhile, antipruritic effect is bad, can also affect life, work and mood.
The content of the invention
For the problems referred to above, it is an object of the invention to provide a kind of safety, the significant composition of antipruritic effect, and by group
Compound is applied in the emulsion that mosquito control is bitten so as to good inhibiting bacteria and diminishing inflammation, antipruritic effect.
A kind of anti-pruritic compositions that the present invention is provided, the anti-pruritic compositions are composed of the following components in parts by weight：Fall down to the ground
Bell extract 0.5-3 parts, purslane extract 0.1-1.5 parts, Lavender 0.3-0.8 parts, camphor 0.5-1 parts, borneol
0.1-0.5 parts.
The preparation method of cardiospermum halicacabum extract of the present invention is as follows：
(1) dry cardiospermum halicacabum is ground into into the cardiospermum halicacabum material powder that average grain diameter is 20～70 mesh；
(2) the cardiospermum halicacabum material powder obtained in step (1) is put in extraction vessel, 15 times are added in extraction vessel
75% ethanol solution, refluxing extraction 2 times, 2 hours every time, concentration, cardiospermum halicacabum extract is obtained after dry, pulverize.
The preparation method of purslane extract of the present invention is as follows：
(1) 1 part of purslane fresh grass is weighed, by 1:The purslane fresh grass is immersed the immersion of 80% ethanol by 10 solid-liquid ratio
30min；
(2) mixed liquor of step (1) is placed in into heating and refluxing extraction 1-2.5h in water-bath, is filtered, collect filtrate, filter residue is used
8 times of 80% ethanol of amount repeat to extract once, merge filtrate twice；
(3) by the filtrate reduced in volume of step (2) to without alcohol taste, concentrate is adsorbed by AB-8 macroporous resin columns,
First with distillation water elution, then 60% ethanol elution is used, collect 60% ethanol eluate, after reduced pressure concentration, obtain purslane extraction
Thing.
The present invention also provides application of the anti-pruritic compositions in treatment bite by mosquitos emulsion is prepared.
One kind that the present invention is provided treats bite by mosquitos emulsion, is made up of the raw material of following weight portion：Anti-pruritic compositions
9.7-36 parts, saualane 3-5 parts, carbonic acid dioctyl ester 3-5 parts, volatile silicone oils 3-5 part, monoglyceride 0.5-1.5 parts, octadecyl alcolol 1-
3 parts, glucoside emulsifying agent 1-2 parts, methyl hydroxybenzoate 0.1-1 parts, propylben 0.1-1 parts, propane diols 5-8 parts, allantois
Plain 0.1-0.5 parts, dipotassium glycyrrhizinate 0.1-0.5 parts, xanthan gum 0.1-0.5 parts, the peaceful 2-5 parts of Yi Mo, deionized water 65-75 part.
Effect or feature of plant component of the present invention is as follows：
Containing Quercetin, chrysoeriol, rutin, methoxycinnamate acetoacetic ester, apiolin etc. in cardiospermum halicacabum extract.Reed
3 rutinosides of the fourth for Quercetin, which contains phenolic hydroxyl structure, can react with active oxygen radical and generate the half of resonance stabilized
Quinoid free radical, terminates free chain reaction, plays antioxidation；Chrysoeriol can effectively protecting skin damage,
Anhydroalkannin, antiallergy.
Purslane extract contains norepinephrine, many first salt, betanidin, glutamic acid, aspartic acid, flavones and soap
Glucoside.Wherein, flavones and saponin, can be with delay skin aging with free radical and antioxidation is gone；Amino acid can shrink blood
Pipe smooth muscle, shrinks the used maincenter having concurrently and peripheral, can releive skin and suppression pruitus.
The complex mixture that Lavender is made up of many different types of aromatic compounds, predominantly fragrant camphor tree
Alcohol, acetic acid linalool, cineole, rosemary, its fragrance can make one to be in a cheerful frame of mind, and affect the change of sympathetic Holy Bible system.Its
In, cineole can be cooked anodyne, and aromatotherapy can mitigate the pain sensation, by improving intracellular loops phosphoric acid glycosides level, relaxing smooth muscle
And produce vasodilator effect；Linalool is Lavender antimicrobial component, can suppress the growth of 17 kinds of bacterium；Its fan contained changes
Fragrant acid can suppress the peroxidating of lipid, can promote wound healing or reduce scar.
Camphor Central nervous system has excitation, is applied in the refrigerant sense that skin can produce similar peppermint, has slight
Local anaesthesia is acted on.《Collected statements on the herbal foundation》Described in camphor can control all itch, worm scabies and all stubborn dermatitis and have worm person.
The device have the advantages that as follows：(1) during the mosquito control that the present invention is provided bites composition, cardiospermum halicacabum is carried
Take that the effective protecting skin of thing is damaged, releive pruitus, camphor treatment itch, Lavender of purslane extract promotes wound
Healing, four kinds of active ingredients are arranged in pairs or groups according to specific ratio, reconcile mutually, cooperate with rich in multiple efficacies composition, can it is antibacterial,
Anti-inflammatory, has compounded borneol, promotes the infiltration of product, beneficial to the absorption of active ingredient, realizes good itching-relieving efficacies；(2) originally
The raw material that the composition of invention is adopted all is natural origin, safely and effectively, is had no side effect, and has met modern and has pursued environmental protection and close
Wish of the reason using natural resources；(3), in the emulsion that mosquito control of the present invention is bitten, formula emulsification system is good, compatibility
It is good with rheological characteristic.In addition, its preparation process is simple, has good market value.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
The embodiment of the present invention 1～3 and the treatment of comparative example 1～2 bite by mosquitos emulsion formulations are shown in Table one
Table one
Treatment bite by mosquitos method of preparing emulsion comprises the steps：
(1) Yi Moning is added in a small amount of propane diols, mixing and stirring is standby；
(2) deionized water, methyl hydroxybenzoate are mixed and heated to into 90 DEG C, add xanthan gum, quick dispersed with stirring is uniform, protects
Allantoin is added after warm 1h；
(3) saualane, carbonic acid dioctyl ester, monoglyceride, octadecyl alcolol, glucoside emulsifying agent, propylben mixing are added
Heat is to 90 DEG C, standby after being incubated 30 minutes；
(4) step (2) material is mixed with step (3) material, homogeneous 15 minutes adds volatile silicone oils in homogeneous,
Stirring cooling；
(5) when being cooled to 55 DEG C, step (1) material, anti-pruritic compositions, dipotassium glycyrrhizinate are added, is stirred, continued cold
But；
(6) 35 DEG C are cooled to, discharge filling, packaging.
Efficacy validation
Experimental subjects：After selecting 30 to 45 years old bite by mosquitos, the patient of pruitus 480 is randomly divided into three groups, embodiment 1
～5,1～3 per group of 60 people of comparative example, 5 control group of comparative example (are distinguished as not adding anti-pruritic compositions with embodiment 1).Patient applies
Smear rear curative effect and be shown in Table two, action refers to that itch substantially mitigates, and healing refers to that symptom is completely eliminated.
Table two
| Example | Number of cases (people) | Work within 2 minutes | Cure within 40 minutes | Play efficiency | Cure rate |
| Embodiment 1 | 60 | 58 | 60 | 96.7% | 100% |
| Embodiment 2 | 60 | 58 | 60 | 96.7% | 100% |
| Embodiment 3 | 60 | 59 | 60 | 98.3% | 100% |
| Comparative example 1 | 60 | 30 | 36 | 50% | 60% |
| Comparative example 2 | 60 | 35 | 40 | 58.3% | 66.7% |
| Comparative example 3 | 60 | 23 | 34 | 38.3% | 56.7% |
| Comparative example 4 | 60 | 22 | 35 | 36.7% | 58.3% |
| Comparative example 5 | 60 | 15 | 20 | 20% | 33.3% |
Bite by mosquitos emulsion is treated by made by two visible embodiment of table, 1～3 anti-pruritic compositions of the present invention averagely to be had for 2 minutes
, up to 97.2%, 4 hours cure rates are up to 100% apparently higher than comparative example 1～5, treatment made by anti-pruritic compositions of the present invention for efficiency
Bite by mosquitos emulsion is in treatment because pruitus has remarkable result caused by bite by mosquitos.Comparative example 3 and the treatment mosquito of comparative example 4
The efficient of sting emulsion 2 minutes is only 38.3% and 36.7%, 4 hours cure rates be 56.7% and 58.3% well below
Other embodiment and comparative example, it can be seen that in anti-pruritic compositions of the present invention, cardiospermum halicacabum extract and purslane extract are played
The effect of Synergistic.
Above example only illustrates embodiment of the present invention, does not have any pro forma restriction to the present invention；Appoint
What is engaged in professional and technical personnel, all has the ability to make some changes using the technology contents for disclosing or modifies, becomes equivalent
The Equivalent embodiments of change, according to the technology of the present invention essence, carry out simply modification, equivalent variations and modification, belong to the present invention
In the range of technical solution of the present invention.
Claims (5)
1. a kind of anti-pruritic compositions, it is characterised in that the anti-pruritic compositions are composed of the following components in parts by weight：
Cardiospermum halicacabum extract 0.5-3 parts
Purslane extract 0.1-1.5 parts
Lavender 0.3-0.8 parts
Camphor 0.5-1 parts
Borneol 0.1-0.5 parts.
2. a kind of anti-pruritic compositions according to claim 1, it is characterised in that the preparation method of the cardiospermum halicacabum extract
It is as follows：
(1) dry cardiospermum halicacabum is ground into into the cardiospermum halicacabum material powder that average grain diameter is 20～70 mesh；
(2) the cardiospermum halicacabum material powder obtained in step (1) is put in extraction vessel, 15 times is added in extraction vessel
75% ethanol solution, refluxing extraction 2 times, 2 hours every time, concentration obtained cardiospermum halicacabum extract after dry, pulverize.
3. a kind of anti-pruritic compositions according to claim 1, it is characterised in that the preparation method of the purslane extract
It is as follows：
(1) 1 part of purslane fresh grass is weighed, by 1:The purslane fresh grass is immersed the immersion of 80% ethanol by 10 solid-liquid ratio
30min；
(2) mixed liquor of step (1) is placed in into heating and refluxing extraction 1-2.5h in water-bath, is filtered, collect filtrate, filter residue is with 8 times
Measure 80% ethanol to repeat to extract once, merge filtrate twice；
(3) by the filtrate reduced in volume of step (2) to without alcohol taste, concentrate is adsorbed by AB-8 macroporous resin columns, is first used
Distillation water elution, then 60% ethanol elution is used, 60% ethanol eluate is collected, purslane extract after reduced pressure concentration, is obtained.
4. application of the anti-pruritic compositions according to any one of claim 1-3 in treatment bite by mosquitos emulsion is prepared.
5. one kind treats bite by mosquitos emulsion, it is characterised in that the emulsion is made up of the raw material of following weight portion：
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710007061.4A CN106511580A (en) | 2017-01-04 | 2017-01-04 | Itching relieving composition and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710007061.4A CN106511580A (en) | 2017-01-04 | 2017-01-04 | Itching relieving composition and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106511580A true CN106511580A (en) | 2017-03-22 |
Family
ID=58335337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710007061.4A Pending CN106511580A (en) | 2017-01-04 | 2017-01-04 | Itching relieving composition and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106511580A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108392539A (en) * | 2018-03-30 | 2018-08-14 | 朱小辉 | It is a kind of can drink mosquito-expelling and antipruritic analgesic plant juice, preparation method and applications |
| CN108926623A (en) * | 2017-05-25 | 2018-12-04 | 大江生医股份有限公司 | Application of anemone extract in preparation of composition for improving SOD2 gene expression, repairing skin and preventing ultraviolet light damage |
| CN109199965A (en) * | 2018-11-26 | 2019-01-15 | 天津郁美净集团有限公司 | A kind of skin care compositions and preparation method thereof having effects that antiallergic is releived |
| CN110960598A (en) * | 2019-12-26 | 2020-04-07 | 广东暨晴生物医药科技有限公司 | Natural plant antibacterial ointment containing folium artemisiae argyi extract and preparation method thereof |
| CN114836986A (en) * | 2022-05-09 | 2022-08-02 | 深圳初和服饰有限公司 | Cool antibacterial fabric and preparation method thereof |
-
2017
- 2017-01-04 CN CN201710007061.4A patent/CN106511580A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108926623A (en) * | 2017-05-25 | 2018-12-04 | 大江生医股份有限公司 | Application of anemone extract in preparation of composition for improving SOD2 gene expression, repairing skin and preventing ultraviolet light damage |
| CN108392539A (en) * | 2018-03-30 | 2018-08-14 | 朱小辉 | It is a kind of can drink mosquito-expelling and antipruritic analgesic plant juice, preparation method and applications |
| CN109199965A (en) * | 2018-11-26 | 2019-01-15 | 天津郁美净集团有限公司 | A kind of skin care compositions and preparation method thereof having effects that antiallergic is releived |
| CN110960598A (en) * | 2019-12-26 | 2020-04-07 | 广东暨晴生物医药科技有限公司 | Natural plant antibacterial ointment containing folium artemisiae argyi extract and preparation method thereof |
| CN114836986A (en) * | 2022-05-09 | 2022-08-02 | 深圳初和服饰有限公司 | Cool antibacterial fabric and preparation method thereof |
| CN114836986B (en) * | 2022-05-09 | 2023-09-08 | 深圳初和服饰有限公司 | Cold-feeling antibacterial fabric and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106511580A (en) | Itching relieving composition and application thereof | |
| CN109078165B (en) | Composition for nursing female private parts and preparation method and application thereof | |
| US20070134195A1 (en) | Topical Analgesic for Sensitive Skin | |
| CN103110868B (en) | Skin care solution and preparation method thereof | |
| CN101229109B (en) | Skin protectant suitable for 7-12 months old infant skin and preparing process thereof | |
| WO2017101790A1 (en) | Pharmaceutical composition for treating cutaneous pruritus and use thereof | |
| CN114272339A (en) | A Chinese medicinal composition for treating eczema, skin allergy or psoriasis, and its preparation method | |
| CN106214571B (en) | Melia azedarach mosquito-repellent composition and preparation method and application thereof | |
| CN104224925B (en) | A kind of mosquito-expelling and antipruritic Chinese medicine composition and application thereof | |
| CN112807259A (en) | Safe and nontoxic mosquito repelling composition and preparation method and application thereof | |
| CN111803603A (en) | A medicinal preparation for treating dermatoses and bacterial virus caused by mosquito bite | |
| CN104706840A (en) | Compound tea tree essential oil for preventing and treating mosquito bite | |
| CN116210732A (en) | Preparation method and application of mite-removing and odor-removing plant extract combination liquid | |
| CN105708763A (en) | Artemisia argyi Levl extract-containing floral water and preparation method thereof | |
| CN111544553B (en) | Natural plant mosquito-repelling and itching-relieving composition containing volatile oil of Tibetan schizonepeta and application of natural plant mosquito-repelling and itching-relieving composition | |
| CN104186577A (en) | Slow-release electrothermal mosquito incense liquor containing ambergris extract and preparation method | |
| JP6590233B1 (en) | Skin disease therapeutic agent and method for producing the same | |
| CN104206444B (en) | A kind of electric liquid device fragrant containing lavender natural and preparation method | |
| CN107536937B (en) | A topical Chinese medicinal liquid for treating dermatoses and onychomycosis, and its preparation method | |
| CN110946163A (en) | Traditional Chinese medicine extract mosquito repellent cream and preparation method thereof | |
| CN104069410A (en) | Liquid medicine for treating dermatophytosis | |
| CN106728069B (en) | Slough-removing and tissue regeneration-promoting paste for treating scalds and burns | |
| CN115089675B (en) | Medicine for treating sphagnum and preparation method thereof | |
| Khofifah et al. | The Effectiveness of Ethanolic Extract of Centella asiatica (L.) on Healing Minor Recurrent Aphthous Stomatitis in Wistar Male Rats (Rattus norvegicus) | |
| CN112618438B (en) | Mosquito repelling composition suitable for children and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170322 |
|
| WD01 | Invention patent application deemed withdrawn after publication |